9 results on '"Bilir, Özlem Arman"'
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2. JUVENILE MYELOMONOCYTIC LEUKEMIA SINGLE CENTER EXPERIENCE
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Akcabelen, Yunus Murat, primary, Kaçar, Dilek, additional, Yozgat, Ayça Koca, additional, Bilir, Özlem Arman, additional, Gökçebay, Dilek Gürlek, additional, Bayhan, Turan, additional, Bozkaya, İkbal Ok, additional, Özbek, Namık Yaşar, additional, and Yaralı, Neşe, additional
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- 2021
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3. EFFECT OF GRAFT VERSUS HOST DISEASE PROPHYLAXIS ON THE LEUKEMIA FREE SURVIVAL IN PEDIATRIC PATIENTS WHO HEMATOPOETIC STEM CELL TRANSPLANTED FOR LEUKEMIA
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Boran, Özge Aylin, Bozkaya, İkbal Ok, Kanbur, Mehtap Olcar, Bilir, Özlem Arman, and Özbek, Namık Yaşar
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- 2023
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4. Total Body Irradiation in Pediatric Patients: Single Center Results.
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İnan, Gonca Altınışık, Aral, İpek Pınar, Gani, Zerrin, Var, Gizem, Ayrak, Fatma Betül, Daşgın, Feyza Yaşar, Bozkaya, İkbal Ok, Bilir, Özlem Arman, Özbek, Namık, Arslan, Süheyla Aytaç, and Tezcan, Yılmaz
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STATISTICS ,BONE marrow transplantation ,LEUCOPENIA ,CONFIDENCE intervals ,LYMPHOBLASTIC leukemia ,APLASTIC anemia ,LOG-rank test ,MULTIVARIATE analysis ,NEUTROPENIA ,RETROSPECTIVE studies ,QUANTITATIVE research ,FISHER exact test ,RISK assessment ,COMPARATIVE studies ,BLOOD diseases ,DESCRIPTIVE statistics ,CHI-squared test ,KAPLAN-Meier estimator ,RADIATION doses ,RADIOTHERAPY ,ODDS ratio ,DATA analysis software ,BETA-Thalassemia ,T-cell lymphoma ,DISEASE risk factors ,CHILDREN - Abstract
Introduction: Total body irradiation (TBI) with megavolt photon energy is a treatment that can be applied before bone marrow transplantation (BMT) in many hematologic diseases. Two-dimensional TBI (2D-TBI) is one of the oldest RT techniques. We performed a retrospective study to evaluate the radiotherapy (RT)-related acute adverse events in pediatric patients with TBI. Methods: Patients who received TBI between January 1, 2021, and December 30, 2021, in the Radiation Oncology Clinic of Ankara City Hospital were evaluated retrospectively. The primary endpoint of the study was the assessment of RT-related acute adverse events (RT-AE). The Common Terminology Criteria for Adverse Events (CTCAE) version 5.0 was used for RT-AE. Results: Twenty-one pediatric patients treated with 2D-TBI between February 20, 2021, and October 10, 2021, have been retrospectively analyzed. The median follow-up period is 7 (range 1-14) months. The median age of the patients is 11 (range 2-17) years. The median time to BMT following TBI is 4 (range 3-13) days. A total of 12 Gy was applied to 15 (71.4%) patients diagnosed with acute lymphoblastic leukemia and acute myeloid leukemia. A total of 3 Gy was applied to 5 (23.8%) patients due to aplastic anemia and thalassemia major. A total of 4 Gy was applied to 1 (4.8%) patient who had anaplastic large cell lymphoma. In the first week after TBI, all 21 (100%) patients were neutropenic in grade 3 or higher. One day after TBI, there was a 23.4% increase in grade 3 or higher leukopenia [p=0.042; OR (95% CI) 0.278 (0.132-0.585)]. Discussion and Conclusion: The 2D-TBI is applied with acceptable toxicity. TBI-related pneumonia was not observed in any of the patients in our treatment technique with a dose/rate of 0.053 Gy/min. [ABSTRACT FROM AUTHOR]
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- 2022
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5. Evaluation of early-onset cardiotoxic effects of anthracyclines used during the treatment of childhood acute lymphoblastic leukemia by speckle-tracking echocardiography.
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Bilir, Özlem Arman, Çetin, İbrahim İlker, Kaçar, Dilek, Aker, Can Barış, Özbek, Namık Yaşar, and Yaralı, Neşe
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LYMPHOBLASTIC leukemia , *ACUTE leukemia , *SPECKLE tracking echocardiography , *ANTHRACYCLINES , *SYMPTOMS , *LEFT ventricular hypertrophy , *INTERSTITIAL cystitis - Abstract
Objective: Anthracyclines are widely used in the treatment of acute lymphoblastic leukemia (ALL). However, cardiotoxicity is the most critical side effect that requires dose limitation. It is thought to occur at first exposure, but the clinical presentation may occur years later. In this study, we aimed to determine the time of initial damage and cardiotoxicity that develops in children with ALL. Methods: In this prospective study, 13 patients with newly diagnosed intermediate-risk precursor B cell ALL treated with the ALL-IC BFM 2009 protocol were included. Conventional echocardiography, tissue Doppler imaging (TDI), and speckle-tracking echocardiography (STE) were performed in all the patients before chemotherapy, after completing the induction phase, and at the end of the reinduction phase. Results: The mean age of the patients was 7.8±4.6 (3.1–16.3) years. Myocardial velocity during systole (Sm) determined by TDI at the interventricular septum significantly decreased during the induction phase. Despite a decrease in STE parameters, a statistically significant reduction was determined in the global longitudinal strain rate at both left and right ventricles at the end of the induction. Nevertheless, a statistically significant increase was observed among the conventional echocardiographic findings in the left ventricular end-diastolic diameter at the end of the reinduction. Conclusion: During the treatment of ALL, subclinical anthracycline-associated cardiotoxicity develops in the early stages of treatment. The findings detected by TDI and STE could be missed by conventional echocardiography. We recommend evaluating patients with these newly developed techniques to detect subclinical cardiotoxicity at an early stage and starting appropriate therapy on time. [ABSTRACT FROM AUTHOR]
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- 2022
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6. Effect of the Mthfr Polymorphisms on Survival of Children withAcute Lymphoblastic Leukemia
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BİLİR, Özlem Arman, KİRKİZ, Serap, FETTAH, Ali, YARALI, H. Neşe, TUNÇ, Bahattin, and ÖZBEK, Namık Yaşar
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Akut lenfoblastik lösemi,Çocuk,MTHFR polimorfizmi,Sağkalım ,Acute lymphoblastic leukemia,Children,MTHFR polymorphism,Survival - Abstract
Amaç: Folat ilişkili genlerin, polimorfizminin akut lenfoblastik lösemiye (ALL) yatkınlığı etkilediği bildirilmiştir. MTHFR geninde tanımlanmış tek nükleotid polimorfizmlerinden (TNP) T677T veya C1298C allelleri vahşi tip allelere göre (C677C ve A1298A) enzim aktivitesinde azalmaya yol açar. MTHFR gen polimorfizmlerinin ayrıca ALL tedavisinde sıklıkla kullanılan antifolat etkili ilaçların metabolizmasını etkileyerek toksisiteyi artırdığı ve böylece sağkalımı etkilediği bildirilmiştir. Çalışmada kliniğimizde izlediğimiz ALL tanılı hastalarımızda MTHFR’nin her iki polimorfizmlerinin sağkalım üzerinde etkisini inceledik.Gereç ve Yöntemler: B hücreli ALL tanısıyla BFM TRALL 2000 protokolü alan hastaları geriye dönük olarak incelendi. Sekizinci gün mutlak blast sayısı, 15 ve 33. gün kemik iliği verileri yanı sıra MTHFR polimorfizmleri kaydedildi.Bulgular: Çalışmaya 33 erkek, 23 kız, tanı yaşı ortalama 4.73 yıl olan (en küçük-en büyük 1.3-16.75 yıl) toplam 56 hasta alındı. Bu hastaların prognozu incelendiğinde 5 hastanın relaps olduğunu gördük. Çalışmamızda C677T veya A1298C allelinin farklı kombinasyonlarını taşıyan bireylerin sağkalım ve olaysız sağkalımları arasında ilişki bulunamadı.Sonuç: Çalışmamızda MTHFR polimorfizmlerinin ALL’li çocuklarda sağkalım üzerine etkisi gösterilememiştir. Daha çok olguyla yapılacak bir çalışmanın daha kesin sonuçlara varmamızı sağlayacağına inanıyoruz., Objective: Folic acid-related genes’ polymorphisms have been related with a predisposition to acute lymphoblastic leukemia (ALL). Two common polymorphic sites on MTHFR gene; T677T and C1298C may decrease the activity of this enzyme compared to the wild type alleles (C677C and A1298A). The polymorphism may affect the metabolism of antifolate drugs and cause increased drug toxicity and decreased survival. In this study, we evaluated the effect of two frequent polymorphisms on survival of children with ALL.Material and Methods: We retrospectively evaluated patients who had been diagnosed with B cell ALL and then treated with the BFM TRALL 2000 treatment protocol. We recorded their absolute blast counts at day 8, and bone marrow evaluation at days 15 and 33 as well as MTHFR polymorphisms. results: Fifty-six patients [male/female: 33/23, mean age at diagnosis 4.73 years range 1.3-16.75 years)] were included in the study. Out of the 56 patients, 5 developed relapse. There was no relationship between different polymorphic alleles of the MTHFR gene with survival and event-free survival. conclusion: We did not observe any effect of MTHFR polymorphisms on survival of children with ALL. We believe further studies with a larger group of patients are necessary to draw a firm conclusion
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- 2017
7. A Rare Presentation of Herpes Virus Infection in a Child with Acute lymphoblastic leukemia: Herpetic Whitlow
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BİLİR, Özlem Arman, YARALI, H. Neşe, KİRKİZ, Serap, and TUNÇ, Bahattin
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Akut lenfoblastik lösemi,Herpes simpleks,Paronişi ,Acute lymphoblastic leukemia,Herpes simplex,Paronychia - Abstract
Herpetik dolama, parmağın herpes simpleks virüs (HSV) tip 1 veya 2 ile enfeksiyonu sonucu oluşur. Sıklıkla herpes gingivostomatitinin otoinokulasyonu sonucu gelişir ve genellikle elin tek parmağı tutulur. Biz de kliniğimizde relaps T hücreli lösemi tanısıyla izlediğimiz 11 yaşında kız hastada fludarabin, sitozin arabinosid ve idarubisinden oluşan yoğun kemoterapi sonrası gelişen febril nötropeni atağı sırasında herpes gingivostomatitinin otoinokulasyonu sonucu oluşan herpetik dolama olgusunu sunduk., Herpetic whitlow is the infection of fingers by herpes simplex virus (HSV) type 1 or 2. It is frequently caused by autoinoculation of herpes gingivostomatitis and usually one finger of a hand is involved. Here we present a case of an 11-year-old girl having herpetic whitlow by autoinoculation of herpes gingivostomatitis during a febrile neutropenia period while being treated with intense chemotherapy consisting of fludarabin, cytosine arabinoside and idarubicin for a T cell leukemia relapse
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- 2013
8. A Child with Psoriasis, Hypogammaglobulinemia, and Monosomy 7-Positive Myelodysplastic Syndrome
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Özbek, Namik, primary, Erdem, Arzu Yazal, additional, Bilir, Özlem Arman, additional, Kara, Fatma Karaca, additional, Yuksek, Mutlu, additional, Yarali, Nese, additional, Özgüner, Meltem, additional, Yüksek, Nazmiye, additional, and Tunç, Bahattin, additional
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- 2015
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9. NEONATAL MECHANICAL VENTILATION: INDICATIONS, COMPLICATIONS AND OUTCOME
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BİLİR, Özlem Arman, ÜNAL, Sevim, ÖZAYDIN, Eda, and ÇELİK, Fatma Çakmak
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Komplikasyon,endikasyon,mekanik ventilasyon,prognoz,yenidoğan ,Complication,indication,mechanical ventilation,newborn,outcome - Abstract
Giriş: Yenidoğan yoğunbakım ünitelerinde (YYBÜ) mekanik ventilasyon hayat kurtarıcı, mortalite ve morbiditede belirgin azalma sağlayan, oksijenizasyon ve ventilasyonu iyileştiren bir destek tedavi yöntemidir. Bu çalışmada mekanik ventilasyon uygulanan yenidoğanların tedavi endikasyonları, komplikasyonlar ve prognozlarının belirlenmesi amaçlanmıştır.Materyal-Metod: Yenidoğan yoğunbakım ünitemizde 1 Ocak -31 Aralık 2006 tarihlerinde mekanik ventilasyon desteği uygulanan yenidoğanlar retrospektif olarak değerlendirilmek üzere klinik ve laboratuar özellikleri bakımından çalışmaya alındı.Bulgular: Hastanemizde 2006 yılında izlenen 1148 yenidoğandan mekanik ventilasyon desteği uygulanan 73 (%6.4) olgu çalışmaya alındı. Kız / erkek oranı 33/40, term/preterm oranı 30/43, sezaryen / vajinal doğum oranı 29/44, ortalama gestasyon yaşları 35±4.5 hafta (24-42 hafta), doğum ağırlıkları 2326.3±885.5 g (530-3800 g), doğum sonrası yaşları 6.5±11 gün (0-60 gün), 5. dakika Apgar skorları 6.3±2.8 (0-10),mekanik ventilasyon destek süreleri 7.6±7.5 gün (1-35 gün), başvuru anında Clinical Risk İndeks of Babies (CRIB) skorları 5.12±2.96 (0-13) idi. Olgulardan %68.5’i başka merkezden gönderilmişti. Bunlardan sadece dördüne transport esnasında entübasyon ve pozitif basınçlı ventilasyon uygulanmıştı.Ventilasyon desteği uygulanma nedenleri neonatal pnömoni (%24.7), respiratuvar distres sendromu ve/veya prematürite (%21.9), perinatal asfiksi (%13.7), sepsis (%11) idi. Komplikasyon %27.4 oranında gelişti; sırasıyla atelektazi (%15.1), nozokomiyal pnömoni (%13.7), pulmoner kanama (%9.5), pnömotoraks (%6.8) görüldü. Ventilasyon uygulanan yenidoğanlarda mortalite oranı %42.5 (n=31) bulundu, en fazla prematüre doğumla ilişkili nedenler (%20.5) ve majör konjenital anomaliler nedeniyle (%6.8) bebeklerin kaybedildiği görüldü. Mortalite ile başvuru anında CRIB skoru (p=0.014), beşinci dakika Apgar skoru (p0.05).Sonuç: Mekanik ventilasyon uygulaması yenidoğanlarda hayat kurtarıcı bir tedavi şeklidir. Bununla birlikte ventilasyon destek ihtiyacı olan yenidoğanlara bu desteğin verilmesinde gecikme olduğu, ventilasyon destek ihtiyacı olup transport edilen yenidoğanlara transport sırasında ventilatör desteği yapılmadığı, ventilatör uygulandığında gerekli bakımın ve sürekliliğin eğitimli personel tarafından sağlanamadığı durumlarda mortalite ve morbiditede belirgin iyileşme beklenilmemelidir. Ventilasyon uygulanan yenidoğanlarda invaziv girişimlerin azaltılarak sterilizasyon açısından dikkatli olunması morbidite, mortaliteyi ve komplikasyon gelişimini azaltacaktır., Objective: Mechanical ventilation, one of the life saving mode of therapy, decreases morbidity and mortality in neonates, and serves to support adequate ventilation and oxygenation. We aimed to define the neonates, indications, complications and mortality due to mechanical ventilation.Method: We investigated the hospital records of the newborns hospitalized in our neonatal intensive care unit between 1 January 2006 / 31 December 2006. Mechanically ventilated neonates were included in this study.Results: There were 1148 neonates hospitalized over a year study period and 73 of them (6.4%) were included in this study. The ratios of female/male, term/preterm, cesarean/vaginal deliveries were 33/40, 30/43, and 29/44 respectively. The mean birth weight was 2326.3±885.5 g (530-3800 g), postnatal age was 6.5±11 days (0-60 days), gestational age was 35±4.5 weeks (24-42 weeks), 5th minute Apgar score was 6.3±2.8 , Clinical Risk İndeks Scor of Babies (CRIB) score on admission was 5.12±2.96 , mechanical ventilation time was 7.6±7.5 days (1-35 days). The number of neonates transported to our unit was 50 (68.5%). Only 4 of these babies were ventilated by positive pressure ventilation via endotrakeal entubation during the transport. Endications to mechanical ventilation were neonatal pneumonia (24.7%), respiratory distress syndrome and/or prematurity related disorders (21.9%), sepsis (11%) and perinatal asphyxia (13.7%). The ratio of complications was 27.4%, and these were atelectasis (15.1%), nosocomial pneumonia (13.7%), pulmonary haemorrhage (9.5%), pneumotorax (6.8%). The ratio of mortality was 42.5% (n=31), especially in the infants of premature births and major congenital anomalies. We found significant relation between mortality and CRIB score on admission (p=0.014), 5th minute Apgar score (p0.05). Conclusion: Mechanical ventilation is a life saving way of therapy for the neonates. On the other hand, improvement of mortality and morbidity should not be expectate, if there is a delay in the initiation of mechanical ventilation, not to ventilate the babies with insufficient respiration during transportation, not to support these babies under optimal conditions and concurrently by trained health care proffessionals during the application of mechanical ventilation. The mortality, morbidity, and complications of mechanical ventilation in neonates should be decreased by applying appropriate and early support by trained health care proffessionals concurrently, especially without cessation during transport of baby to another hospital, aseptic and minimal invasive procedures in the unit
- Published
- 2009
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