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1. Diagnosis and treatment in chronic pancreatitis: an international survey and case vignette study

Author

Moody, Frank G., Bertrand, Claude, Johnson, Colin, van Lander, Aude, Carter, Ross, Conneely, John B., Berrevoet, Frederik, Sousa Silva, Donzília, Li, Zong-Fang, Lévy, Philippe, Oppong, Kofi, Gardner, Timothy B., Wilcox, C. Mel, French, Jeremy, Steer, Michael, Bradley, Edward L., III, Layer, Peter, Napoleon, Bertrand, Mosquera, Jorge Antonio, Gouma, D.J., Andersson, Roland, Manzelli, Antonio, Klaase, J.M., Falconi, Massimo, de-Madaria, Enrique, Casadei, Riccardo, Malleo, Giuseppe, Pezzilli, Raffaele, Malecka-Panas, Ewa, Lohr, Matthias, Mayerle, Julia, Rauws, Erik A.J., Freeman, Martin L., Ariffin, Affirul Chairil, Vasavada, Bhavin, Lai, Paul Bo-San, Beristain-Hernandez, Jose Luis, Juan, Álvarez, Plaudis, Haralds, Vrochides, Dionisios, Neri, Vincenzo, Velayutham, Vimalraj, Andrianov, Aleksey, Figueras, Joan, Soreide, Kjetil, Shcherba, Aliaksei, Gachabayov, Mahir, Keith, Roger G., Tsoulfas, Georgios, Fink, Michael Anthony, Crippa, Stefano, Nikfarjam, Mehrdad, Bora, Dibyajyoti, Desai, Rajendra, Donati, Marcello, Bong, Jan Jin, Martínez Moneo, Emma, Morris-Stiff, Gareth, Coker, Ahmet, de Resende, Alexandre Prado, Bhalerao, Suryabhan Sakhahari, Sikora, Sadiq S., Kelemen, Dezső, Czakó, László, Ramesh, Hariharan, Rummo, Oleg, Fedaruk, Aliaksei, Hlinnik, Alexey, Chinthakindi, Madhusudhan, Dumitrascu, Traian, Egorov, Vyacheslav, Bettschart, Vincent, Molinari, Michele, Guillermo, E. Aldana D., Orloff, Susan L., Kostov, Daniel Vasilev, Sulpice, Laurent, Knowles, Brett, Kimura, Yasutoshi, Marangoni, Gabriele, Joshi, Rajeev, Gyökeres, Tibor, Bedin, Vladimir, V., Ivanecz, Arpad, Antonucci, Adelmo, Omoshoro-Jones, Jones A.O., Nakache, Richard, Del Chiaro, Marco, Johnstone, Marianne, Saito, Tomoaki, Balzano, Gianpaolo, Chooklin, Serge, Boraschi, Piero, Park, Walter, Pereira, Pedro Nuno Valente Reis, Pagano, Nico, Lykoudis, Pavlos, Partecke, Lars Ivo, Siatkouski, Aliaksandr, Martín, Rosa Jorba, Kawabata, Yasunari, Lourenço, Luís Carvalho, Marra-Lopez, Carlos, Lee, Jun Kyu, Habbe, Nils, Verdonk, Robert C., Rabotyagova, Yliya, Talukdar, Rupjyoti, Frulloni, Luca, Galeev, Shamil, Berger, Zoltán, Yasuda, Takeo, Hackert, Thilo, Saatov, Ziyovuddin, Raptis, Dimitri Aristotle, Boadas, Jaume, Vitali, Francesco, Archibugi, Livia, Ryska, Miroslav, Tihanyi, Balazs, Singh, Vikesh K., Masamune, Atsushi, Yeaton, Paul, Smith, Kerrington D., Modi, Shrey, Cosen-Binker, Laura, Barreto, Savio George, Morandi, Eugenio, Valeri, Sergio, Morioka, Cintia Yoko, Lara, Luis F., Takeyama, Yoshifumi, Gress, Frank G., Yu, Young-Dong, Gaia, Ezio, Barbu, Sorin Traian, İnce, Ali Tüzün, Deeprasertvit, Akkraporn, Chang, Yu-Ting, Abiola, Stephen Olusola, Kacar, Sabite, Muscarella, Peter, II, Braat, Henri, Han, Samuel, Aghdassi, Ali A., Frossard, Jean-Louis, Smith, Jill P., Schwartz, M.P., van Dullemen, H.M., Venneman, N.G., Spanier, B.W.M., Kuiken, Sjoerd, van Geenen, Erwin, Beilman, Greg, Papachristou, Georgios, Chapa Azuela, Oscar, van der Schaar, P., Oruc, Nevin, Anten, Marie-Paule, Nealon, William H., García-Cano, Jesús, Jovani, Manol, Melki, Ziad, Ibrahim, Mustafa Mohammed Ahmed, Awajdarip, M.U., Azam, Mohammad, Sabu, K.G., Ermolaev, Igor, Shetty, Shiran, Oana, Belei, Pokrotnieks, Juris, Lazuchiewicz-Kot, Malgorzata, Bouali, Riadh, Winiarski, Marek, Schmitt, Marcus, Rimbas, Mihai, Meining, Alexander, Erwan, Bories, Meier, Peter N., Schoefl, Rainer, Altonbary, Ahmed Youssef, Marsteller, Igor, Wallstabe, Ingo, Prifti, Skerdi, Lemmers, Arnaud, Horvath, M., Kumar, Ajay, Palermo, Joseph J., Issa, Yama, van Santvoort, Hjalmar C., Fockens, Paul, Besselink, Marc G., Bollen, Thomas L., Bruno, Marco J., and Boermeester, Marja A.

Published
2017
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3. Model de relació entre l’atenció primària i comunitària i l’atenció hospitalària ambulatòria

Author

Abilleira, Sònia, Algar, Daniel, Barahona Marco, Marta, Benaque, Alba, Benavent, Jaume, Boada, Albert, Boadas, Jaume, Borràs, Xavier, Carrasco, Ignasi, Carrasco, Marta, Carod, Cristina, Casajuana, Josep, Cebrián, Rocío, Enfedaque Montes, M. Belén, Escosa, Àlex, Espinalt, Marta, Estrada, Oriol, Ferrer, Daniel, Garcia, Oriol, Gómez, Maite, Ingla, Jordi, Llussa, Judit, Lopez, David, Mármol, José, Moreno, Nemesio, Navasquillo Calderon, Amparo, Peiró, Ricard, Regaña, Daniel, Rodoreda, Sara, Romero, Rosa, Ruiz, Rafael, Solans, Oscar, Vall Llosera, Anna, Mas, Ariadna, Gil, Esther, and Departament de Salut

Subjects
atención a la salud (salud pública)::niveles de atención a la salud::atención a la salud (salud pública)::atención primaria de la salud [SALUD PÚBLICA], Atenció primària, Serveis sanitaris, Health Care (Public Health)::Health Care Levels::Health Care (Public Health)::Primary Health Care [PUBLIC HEALTH], atención a la salud (salud pública)::prestación sanitaria::atención hospitalaria [SALUD PÚBLICA], atención a la salud (salud pública)::servicios de salud [SALUD PÚBLICA], Health Care (Public Health)::Health Services [PUBLIC HEALTH], Health Care (Public Health)::Delivery of Health Care::Hospital Care [PUBLIC HEALTH], Assistència hospitalària
Abstract

Atenció primària; Atenció hospitalària; Pacient Atención primaria; Atención hospitalaria; Paciente Primary care; Hospital care; Patient L’objectiu del present document és definir un model de relació entre l’atenció primària i comunitària i l’atenció hospitalària ambulatòria que doni una resposta resolutiva, equitativa i de qualitat durant tot el procés assistencial. A tal fi es defineix el diagrama del procés assistencial pel qual els metgesa especialistes de medicina de família i comunitària (MFiC) sol·liciten l’atenció, mitjançant l’ordre clínica, dels seus homòlegs d’atenció hospitalària ambulatòria (MAH). A més, s’estableixen un seguit de recomanacions relatives a la relació que s’estableix entre l’MFiC i el MAH a l’hora de contribuir a la millora de la salut de la persona atesa.

Published
2023

4. Predictive Value of Carcinoembryonic Antigen in Symptomatic Patients without Colorectal Cancer: A Post-Hoc Analysis within the COLONPREDICT Cohort

Author

Pin-Vieito, Noel, primary, Iglesias, María José, additional, Remedios, David, additional, Álvarez-Sánchez, Victoria, additional, Fernández-Bañares, Fernando, additional, Boadas, Jaume, additional, Martínez-Bauer, Eva, additional, Campo, Rafael, additional, Bujanda, Luis, additional, Ferrández, Ángel, additional, Piñol, Virginia, additional, Rodríguez-Alcalde, Daniel, additional, Menéndez-Rodríguez, Martín, additional, García-Morales, Natalia, additional, Pérez-Mosquera, Cristina, additional, and Cubiella, Joaquín, additional

Published
2020
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5. Predictive Value of Carcinoembryonic Antigen in Symptomatic Patients without Colorectal Cancer: A Post-Hoc Analysis within the COLONPREDICT Cohort

Author

Medicina, Medikuntza, Pin Vieito, Noel, Iglesias, María José, Remedios, David, Álvarez Sánchez, Victoria, Fernández Bañares, Fernando, Boadas, Jaume, Martínez Bauer, Eva, Campo, Rafael, Bujanda Fernández de Pierola, Luis, Ferrández, Ángel, Piñol, Virginia, Rodríguez Alcalde, Daniel, Menéndez Rodríguez, Martín, García Morales, Natalia, Pérez Mosquera, Cristina, Cubiella, Joaquín, Medicina, Medikuntza, Pin Vieito, Noel, Iglesias, María José, Remedios, David, Álvarez Sánchez, Victoria, Fernández Bañares, Fernando, Boadas, Jaume, Martínez Bauer, Eva, Campo, Rafael, Bujanda Fernández de Pierola, Luis, Ferrández, Ángel, Piñol, Virginia, Rodríguez Alcalde, Daniel, Menéndez Rodríguez, Martín, García Morales, Natalia, Pérez Mosquera, Cristina, and Cubiella, Joaquín

Abstract

We aimed to assess the risk of cancer in patients with abdominal symptoms after a complete colonoscopy without colorectal cancer (CRC), according to the carcinoembryonic antigen (CEA) concentration, as well as its diagnostic accuracy. For this purpose, we performed a post-hoc analysis within a cohort of 1431 patients from the COLONPREDICT study, prospectively designed to assess the fecal immunochemical test accuracy in detecting CRC. Over 36.5 ± 8.4 months, cancer was detected in 115 (8%) patients. Patients with CEA values higher than 3 ng/mL revealed an increased risk of cancer (HR 2.0, 95% CI 1.3–3.1), CRC (HR 4.4, 95% CI 1.1–17.7) and non-gastrointestinal cancer (HR 1.7, 95% CI 1.0–2.8). A new malignancy was detected in 51 (3.6%) patients during the first year and three variables were independently associated: anemia (OR 2.8, 95% CI 1.3–5.8), rectal bleeding (OR 0.3, 95% CI 0.1–0.7) and CEA level >3 ng/mL (OR 3.4, 95% CI 1.7–7.1). However, CEA was increased only in 31.8% (95% CI, 16.4–52.7%) and 50% (95% CI, 25.4–74.6%) of patients with and without anemia, respectively, who would be diagnosed with cancer during the first year of follow-up. On the basis of this information, CEA should not be used to assist in the triage of patients presenting with lower bowel symptoms who have recently been ruled out a CRC

Published
2020

6. Risk of gastrointestinal cancer in a symptomatic cohort after a complete colonoscopy: role of faecal immunochemical test

Author

Medicina, Medikuntza, Pin Vieito, Noel, Iglesias, María J, Remedios, David, Rodríguez Alonso, Lorena, Rodriguez Moranta, Francisco, Álvarez Sánchez, Victoria, Fernández Bañares, Fernando, Boadas, Jaume, Martínez Bauer, Eva, Campo, Rafael, Bujanda Fernández de Pierola, Luis, Ferrández, Ángel, Piñol, Virginia, Rodríguez Alcalde, Daniel, Guardiola, Jordi, Cubiella, Joaquín, COLONPREDICT study investigators, Medicina, Medikuntza, Pin Vieito, Noel, Iglesias, María J, Remedios, David, Rodríguez Alonso, Lorena, Rodriguez Moranta, Francisco, Álvarez Sánchez, Victoria, Fernández Bañares, Fernando, Boadas, Jaume, Martínez Bauer, Eva, Campo, Rafael, Bujanda Fernández de Pierola, Luis, Ferrández, Ángel, Piñol, Virginia, Rodríguez Alcalde, Daniel, Guardiola, Jordi, Cubiella, Joaquín, and COLONPREDICT study investigators

Abstract

BACKGROUND Faecal immunochemical test (FIT) has been recommended to assess symptomatic patients for colorectal cancer (CRC) detection. Nevertheless, some conditions could theoretically favour blood originating in proximal areas of the gastrointestinal tract passing through the colon unmetabolized. A positive FIT result could be related to other gastrointestinal cancers (GIC). AIM To assess the risk of GIC detection and related death in FIT-positive symptomatic patients (threshold 10 mu g Hb/g faeces) without CRC. METHODS Post hoc cohort analysis performed within two prospective diagnostic test studies evaluating the diagnostic accuracy of different FIT analytical systems for CRC and significant colonic lesion detection. Ambulatory patients with gastrointestinal symptoms referred consecutively for colonoscopy from primary and secondary healthcare, underwent a quantitative FIT before undergoing a complete colonoscopy. Patients without CRC were divided into two groups (positive and negative FIT) using the threshold of 10 mu g Hb/g of faeces and data from follow-up were retrieved from electronic medical records of the public hospitals involved in the research. We determined the cumulative risk of GIC, CRC and upper GIC. Hazard rate (HR) was calculated adjusted by age, sex and presence of significant colonic lesion. RESULTS We included 2709 patients without CRC and a complete baseline colonoscopy, 730 (26.9%) with FIT >= 10 mu gr Hb/gr. During a mean time of 45.5 +/- 20.0 mo, a GIC was detected in 57 (2.1%) patients: An upper GIC in 35 (1.3%) and a CRC in 14 (0.5%). Thirty-six patients (1.3%) died due to GIC: 22 (0.8%) due to an upper GIC and 9 (0.3%) due to CRC. FIT-positive subjects showed a higher CRC risk (HR 3.8, 95%CI: 1.2-11.9) with no differences in GIC (HR 1.5, 95%CI: 0.8-2.7) or upper GIC risk (HR 1.0, 95%CI: 0.5-2.2). Patients with a positive FIT had only an increased risk of CRC-related death (HR 10.8, 95%CI: 2.1-57.1) and GIC-related death (HR 2.2, 95%CI: 1.

Published
2020

8. Additional file 5: of Prediction of advanced colonic neoplasm in symptomatic patients: a scoring system to prioritize colonoscopy (COLONOFIT study)

Author

Fernández-Bañares, Fernando, Clèries, Ramon, Boadas, Jaume, Josepa Ribes, Oliva, Joan, Alsius, Antoni, Sanz, Xavier, Martínez-Bauer, Eva, Galter, Sara, Pujals, Mar, Pujol, Marta, Pozo, Patricia, and Campo, Rafel

Abstract

Figure S1. Tumour localization and staging in both study phases. (DOCX 11 kb)

Published
2019
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9. Additional file 7: of Prediction of advanced colonic neoplasm in symptomatic patients: a scoring system to prioritize colonoscopy (COLONOFIT study)

Author

Fernández-Bañares, Fernando, Clèries, Ramon, Boadas, Jaume, Josepa Ribes, Oliva, Joan, Alsius, Antoni, Sanz, Xavier, Martínez-Bauer, Eva, Galter, Sara, Pujals, Mar, Pujol, Marta, Pozo, Patricia, and Campo, Rafel

Abstract

Table S2 Description of patients included in study phase 1 and 2. (DOCX 22 kb)

Published
2019
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14. Risk of gastrointestinal cancer in a symptomatic cohort after a complete colonoscopy: Role of faecal immunochemical test

Author

Pin-Vieito, Noel, primary, Iglesias, María J, additional, Remedios, David, additional, Rodríguez-Alonso, Lorena, additional, Rodriguez-Moranta, Francisco, additional, Álvarez-Sánchez, Victoria, additional, Fernández-Bañares, Fernando, additional, Boadas, Jaume, additional, Martínez-Bauer, Eva, additional, Campo, Rafael, additional, Bujanda, Luis, additional, Ferrandez, Ángel, additional, Piñol, Virginia, additional, Rodríguez-Alcalde, Daniel, additional, Guardiola, Jordi, additional, Cubiella, Joaquín, additional, and investigators, on behalf of the COLONPREDICT study, additional

Published
2020
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16. Influence of age, body mass index and comorbidity on major outcomes in acute pancreatitis, a prospective nation‐wide multicentre study

Author

Moran, Robert A, primary, García-Rayado, Guillermo, additional, Iglesia-García, Daniel, additional, Martínez-Moneo, Emma, additional, Fort-Martorell, Esther, additional, Lauret-Braña, Eugenia, additional, Concepción-Martín, Mar, additional, Ausania, Fabio, additional, Prieto-Martínez, Carlos, additional, González-de-Cabo, Miguel, additional, Quesada-Vázquez, Noé, additional, Marcaide-Ruiz-de-Apodaca, M Asunción, additional, Pajares-Díaz, José A, additional, Díaz, Francia C, additional, Benito, José L, additional, Hinojosa-Guadix, Jennifer, additional, Marqués-García, Pilar, additional, Boadas, Jaume, additional, Bajador-Andreu, Eduardo, additional, Moreno, Oswaldo, additional, Argüelles-Arias, Federico, additional, Martín-Benítez, Gregorio, additional, Tafur-Sánchez, Carla, additional, Leal-Téllez, Jesús, additional, Romero-Mosquera, Beatriz, additional, Hernaez, Ruben, additional, Papachristou, Georgios I, additional, Singh, Vikesh K, additional, and Madaria, Enrique, additional

Published
2018
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17. Development and external validation of a faecal immunochemical test-based prediction model for colorectal cancer detection in symptomatic patients

Author

Cubiella, Joaquín, Vega, Pablo, Salve, María, Díaz-Ondina, Marta, Alves, Maria Teresa, Quintero, Enrique, Álvarez-Sánchez, Victoria, Fernández Bañares, Fernando, Boadas, Jaume, Campo Fernández de los Rios, Rafael, Bujanda, Luis, Clofent, Juan, Ferrandez, Ángel, Torrealba, Leyanira, Piñol Sánchez, Virgínia, Rodríguez-Alcalde, Daniel, Hernández, Vicent, Fernández-Seara, Javier, Ribes Puig, Josepa, COLONPREDICT study investigators, and Universitat de Barcelona

Subjects
Male, Colorectal cancer, diagnosis, Colonoscopy, risk stratification, Gastroenterology, prompt diagnosis, Hemoglobins, Feces, 0302 clinical medicine, Diagnòstic, colonoscopy, Càncer -- Diagnòstic, Medicine, Prospective Studies, guidelines, Prospective cohort study, Early Detection of Cancer, risk, Medicine(all), Rectum -- Cancer, medicine.diagnostic_test, Immunochemistry, primary-care, Biochemical markers, Area under the curve, Cancer -- Diagnosis, General Medicine, Prognosis, 3. Good health, consultation questionnaire, quality, Tumor markers, 030220 oncology & carcinogenesis, Predictive value of tests, Marcadors bioquímics, Cohort, Female, 030211 gastroenterology & hepatology, diagnostic accuracy, Protocols clínics, Colorectal Neoplasms, Research Article, medicine.medical_specialty, Pronòstic mèdic, colorectal cancer, Risk Assessment, 03 medical and health sciences, Predictive Value of Tests, Càncer colorectal, Internal medicine, Humans, neoplasms, Aged, Gynecology, people, business.industry, Marcadors tumorals, Colonoscòpia, scoring system, Odds ratio, Models, Theoretical, hemoglobin, medicine.disease, faecal immunochemical test, digestive system diseases, Confidence interval, indicators, Carcinoembryonic Antigen, Medical protocols, Cross-Sectional Studies, Recte -- Càncer, business, Leukocyte L1 Antigen Complex, Biomarkers
Abstract

Background: Risk prediction models for colorectal cancer (CRC) detection in symptomatic patients based on available biomarkers may improve CRC diagnosis. Our aim was to develop, compare with the NICE referral criteria and externally validate a CRC prediction model, COLONPREDICT, based on clinical and laboratory variables. Methods: This prospective cross-sectional study included consecutive patients with gastrointestinal symptoms referred for colonoscopy between March 2012 and September 2013 in a derivation cohort and between March 2014 and March 2015 in a validation cohort. In the derivation cohort, we assessed symptoms and the NICE referral criteria, and determined levels of faecal haemoglobin and calprotectin, blood haemoglobin, and serum carcinoembryonic antigen before performing an anorectal examination and a colonoscopy. A multivariate logistic regression analysis was used to develop the model with diagnostic accuracy with CRC detection as the main outcome. Results: We included 1572 patients in the derivation cohort and 1481 in the validation cohorts, with a 13.6 % and 9. 1 % CRC prevalence respectively. The final prediction model included 11 variables: age (years) (odds ratio [OR] 1.04, 95 % confidence interval [CI] 1.02-1.06), male gender (OR 2.2, 95 % CI 1.5-3.4), faecal haemoglobin >= 20 mu g/g (OR 17.0, 95 % CI 10.0-28.6), blood haemoglobin = 3 ng/mL (OR 4.5, 95 % CI 3.0-6.8), acetylsalicylic acid treatment (OR 0.4, 95 % CI 0.2-0.7), previous colonoscopy (OR 0.1, 95 % CI 0.06-0.2), rectal mass (OR 14.8, 95 % CI 5.3-41.0), benign anorectal lesion (OR 0.3, 95 % CI 0.2-0.4), rectal bleeding (OR 2.2, 95 % CI 1.4-3.4) and change in bowel habit (OR 1.7, 95 % CI 1.1-2.5). The area under the curve (AUC) was 0.92 (95 % CI 0.91-0.94), higher than the NICE referral criteria (AUC 0.59, 95 % CI 0.55-0.63; p < 0.001). On the basis of the thresholds with 90 % (5.6) and 99 % (3.5) sensitivity, we divided the derivation cohort into three risk groups for CRC detection: high (30.9 % of the cohort, positive predictive value [PPV] 40.7 %, 95 % CI 36.7-45.9 %), intermediate (29.5 %, PPV 4.4 %, 95 % CI 2.8-6.8 %) and low (39.5 %, PPV 0.2 %, 95 % CI 0.0-1.1 %). The discriminatory ability was equivalent in the validation cohort (AUC 0.92, 95 % CI 0.90-0.94; p = 0.7). Conclusions: COLONPREDICT is a highly accurate prediction model for CRC detection. This study was funded by a grant from Instituto de Salud Carlos III (PI11/00094). JC and VH have received an intensification grant through the European Commission funded "BIOCAPS" project (FP-7-REGPOT 2012-2013-1, Grant agreement no. FP7-316265). The validation cohort recruitment was funded by a grant from Fundacio de la Marato TV3 2012 (785/U/2013). The funding institutions had no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the article for publication.

Published
2016

18. Effect of aspirin on the diagnostic accuracy of the faecal immunochemical test for colorectal advanced neoplasia

Author

Bujanda, Luis, primary, Sarasqueta, Cristina, additional, Vega, Pablo, additional, Salve, María, additional, Quintero, Enrique, additional, Alvarez-Sánchez, Victoria, additional, Fernández-Bañares, Fernando, additional, Boadas, Jaume, additional, Campo, Rafel, additional, Garayoa, Ana, additional, Ferrandez, Angel, additional, Torrealba, Leyanira, additional, Rodríguez-Alcaide, Daniel, additional, D’Amato, Mauro, additional, Hernández, Vicent, additional, and Cubiella, Joaquin, additional

Published
2017
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19. Analysis and Predictive Factors of Splanchnic Vein Thrombosis in Acute Pancreatitis, in a Large National Prospective Cohort

Author

Marra-López, Carlos, primary, Concejo, Federico Bolado, additional, Canaval Zuleta, Héctor J., additional, Marcaide, María Asunción, additional, García-Rayado, Guillermo, additional, Rivera-Irigoin, Robin, additional, Garcia, Francisco Javier Grau, additional, Boadas, Jaume, additional, Millastre, Judith, additional, Martínez-Ares, David, additional, and de-Madaria, Enrique, additional

Published
2017
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20. Development and external validation of a faecal immunochemical test-based prediction model for colorectal cancer detection in symptomatic patients

Author

Medicina, Medikuntza, Cubiella, Joaquín, Vega, Pablo, Salve, María, Díaz-Ondina, Marta, Alves, Maria Teresa, Quintero, Enrique, Álvarez-Sánchez, Victoria, Fernández-Bañares, Fernando, Boadas, Jaume, Campo, Rafel, Bujanda Fernández de Pierola, Luis, Clofent, Joan, Ferrandez, Ángel, Torrealba, Leyanira, Piñol, Virginia, Rodríguez-Alcalde, Daniel, Hernández, Vicent, Fernández-Seara, Javier, COLONPREDICT study investigators, Medicina, Medikuntza, Cubiella, Joaquín, Vega, Pablo, Salve, María, Díaz-Ondina, Marta, Alves, Maria Teresa, Quintero, Enrique, Álvarez-Sánchez, Victoria, Fernández-Bañares, Fernando, Boadas, Jaume, Campo, Rafel, Bujanda Fernández de Pierola, Luis, Clofent, Joan, Ferrandez, Ángel, Torrealba, Leyanira, Piñol, Virginia, Rodríguez-Alcalde, Daniel, Hernández, Vicent, Fernández-Seara, Javier, and COLONPREDICT study investigators

Abstract

Background: Risk prediction models for colorectal cancer (CRC) detection in symptomatic patients based on available biomarkers may improve CRC diagnosis. Our aim was to develop, compare with the NICE referral criteria and externally validate a CRC prediction model, COLONPREDICT, based on clinical and laboratory variables. Methods: This prospective cross-sectional study included consecutive patients with gastrointestinal symptoms referred for colonoscopy between March 2012 and September 2013 in a derivation cohort and between March 2014 and March 2015 in a validation cohort. In the derivation cohort, we assessed symptoms and the NICE referral criteria, and determined levels of faecal haemoglobin and calprotectin, blood haemoglobin, and serum carcinoembryonic antigen before performing an anorectal examination and a colonoscopy. A multivariate logistic regression analysis was used to develop the model with diagnostic accuracy with CRC detection as the main outcome. Results: We included 1572 patients in the derivation cohort and 1481 in the validation cohorts, with a 13.6 % and 9. 1 % CRC prevalence respectively. The final prediction model included 11 variables: age (years) (odds ratio [OR] 1.04, 95 % confidence interval [CI] 1.02-1.06), male gender (OR 2.2, 95 % CI 1.5-3.4), faecal haemoglobin >= 20 mu g/g (OR 17.0, 95 % CI 10.0-28.6), blood haemoglobin <10 g/dL (OR 4.8, 95 % CI 2.2-10.3), blood haemoglobin 10-12 g/dL (OR 1.8, 95 % CI 1.1-3.0), carcinoembryonic antigen >= 3 ng/mL (OR 4.5, 95 % CI 3.0-6.8), acetylsalicylic acid treatment (OR 0.4, 95 % CI 0.2-0.7), previous colonoscopy (OR 0.1, 95 % CI 0.06-0.2), rectal mass (OR 14.8, 95 % CI 5.3-41.0), benign anorectal lesion (OR 0.3, 95 % CI 0.2-0.4), rectal bleeding (OR 2.2, 95 % CI 1.4-3.4) and change in bowel habit (OR 1.7, 95 % CI 1.1-2.5). The area under the curve (AUC) was 0.92 (95 % CI 0.91-0.94), higher than the NICE referral criteria (AUC 0.59, 95 % CI 0.55-0.63; p < 0.001). On the basis of the thresholds with

Published
2016

22. Mo1339 Nation-Wide Multicenter Prospective Validation of the New Severity Classifications of Acute Pancreatitis

Author

de-Madaria, Enrique, primary, Bolado, Federico, additional, Prieto-Martínez, Carlos, additional, de la Higuera, Belén González, additional, Canaval-Zuleta, Héctor J., additional, Lareu, Nelly Balza, additional, de Cabo, Miguel González, additional, Marra-López, Carlos, additional, de Apodaca, María A. Marcaide Ruiz, additional, Orive-Calzada, Aitor, additional, Hernando-Alonso, Ana I., additional, Pajares-Díaz, José Antonio, additional, Gómez-Anta, Ignacio, additional, del Val, Adolfo, additional, Díaz, Francia C., additional, Ferrandez, Angel, additional, Rivera-Irigoin, Robin, additional, Grau-García, Francisco J., additional, Boadas, Jaume, additional, Millastre, Judith, additional, Pascual-Moreno, Isabel, additional, Rodríguez-Oballe, Juan A., additional, López-Serrano, Antonio, additional, Ruiz-Rebollo, María L., additional, Viejo-Almanzor, Alejandro, additional, Lariño-Noia, Jose, additional, Martínez-Moneo, Emma, additional, Fort-Martorell, Esther, additional, Lauret-Braña, María Eugenia, additional, Romero-Mosquera, Beatriz, additional, Concepción-Martín, Mar, additional, Ausania, Fabio, additional, Prada, José I. Rodríguez, additional, Suárez, Silvia Guzmán, additional, and Zapater, Pedro, additional

Published
2015
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24. Safety and efficacy of treatment with pegylated interferon alpha-2a with ribavirin in chronic hepatitis C genotype 4

Author

Urquijo, Juan José, primary, Diago, Moisés, additional, Boadas, Jaume, additional, Planas, Ramón, additional, Solá, Ricard, additional, del Olmo, Juan Angel, additional, Crespo, Javier, additional, Erdozaín, José Carlos, additional, Antón, María Dolores, additional, Arocena, Carlos, additional, Suarez, Dolores, additional, Giné, Josep, additional, Barrera, Josep M, additional, Gracia-Samaniego, Javier, additional, Perez, Ricardo, additional, Dalmau, Blai, additional, and Montoro, Miguel, additional

Published
2013
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26. Effect of aspirin on the diagnostic accuracy of the faecal immunochemical test for colorectal advanced neoplasia

Author

Bujanda, Luis, Sarasqueta, Cristina, Vega, Pablo, Salve, María, Quintero, Enrique, Alvarez-Sánchez, Victoria, Fernández-Bañares, Fernando, Boadas, Jaume, Campo, Rafel, Garayoa, Ana, Ferrandez, Angel, Torrealba, Leyanira, Rodríguez-Alcaide, Daniel, D’Amato, Mauro, Hernández, Vicent, and Cubiella, Joaquin

Abstract

Aspirin (ASA) is a drug that can cause gastrointestinal lesions and symptoms. Colorectal cancer (CRC) is the most prevalent type of cancer in Western countries. We assessed the effect of aspirin on the diagnostic accuracy of the faecal immunochemical test (FIT) for CRC and/or advanced neoplasia (AN) in patients undergoing colonoscopy for gastrointestinal symptoms. We conducted a prospective multicentre observational study of diagnostic tests that included patients with gastrointestinal symptoms undergoing colonoscopy between March 2012 and 2014 (the COLONPREDICT study). Symptoms were assessed and a FIT and blood tests assessing haemoglobin and carcinoembryonic antigen (CEA) levels were performed. The study included 3052 patients: A total of 2567 did not take aspirin (non-user group) and 485 (16%) took aspirin (user group). Continuous treatment with ASA did not change the AUC (0.88, 0.82; p?=?0.06), sensitivity (92%, 88%; p?=?0.5) or specificity (71%, 67%; p?=?0.2) of the FIT for CRC detection. Similarly, we found no differences in the AUC (0.81, 0.79; p?=?0.6), sensitivity (74%, 75.5%; p?=?0.3) or specificity (76%, 73.6%; p?=?0.3) for AN detection. Patients with an aspirin use of?=?300?mg/day had a lower prevalence of AN and the sensitivity, specificity and AUC for AN for these patients were 54%, 68% and 0.66, significantly lower than for the non-user group (p?=?0.03). Aspirin does not modify the diagnostic accuracy of FIT for CRC and/or AN in patients with gastrointestinal symptoms. Aspirin use of?=?300?mg/day decreases the accuracy of the test.

Published
2018
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