99 results on '"Bracco L"'
Search Results
2. Characterization of manic episodes with psychotic symptoms: is psychosis synonymous with severity?
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Gracia, H. Andreu, primary, De Juan Viladegut, Ò., additional, Olivier Mayorga, L., additional, Ochandiano Recio, I., additional, Salmerón Morales, S., additional, Fernández Plaza, T., additional, Bueno Sanya, L., additional, Bracco, L., additional, Giménez Palomo, A., additional, and Pacchiarotti, I., additional more...
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- 2023
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Catalog
3. Depressive predominant polarity in bipolar disorder – a retrospective study in a sample of patients hospitalized for a manic episode
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Bracco, L., primary, Gracia, H. Andreu, additional, De Juan Viladegut, O., additional, Mayorga, L. Olivier, additional, Recio, I. Ochandiano, additional, Salmeròn, S., additional, Sanya, L. Bueno, additional, Plaza, T. Fernàndez, additional, Palomo, A. Gimènez, additional, Pacchiarotti, I., additional, and Vieta, E., additional more...
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- 2023
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4. Antidepressants as predictors of relapse in bipolar disorders
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De Juan Viladegut, O., primary, Gracia, H. Andreu, additional, Olivier Mayorga, L., additional, Fernández Plaza, T., additional, Ochandiano Recio, I., additional, Salmerón, S., additional, Bueno Sanya, L., additional, Bracco, L., additional, Giménez Palomo, A., additional, and Pacchiarotti, I., additional more...
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- 2023
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5. Climate impact on bipolar disorder course: a systematic review and meta-analysis
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Fico, G., primary, Bracco, L., additional, Oliva, V., additional, De Prisco, M., additional, Bort, M., additional, Possidente, C., additional, Vieta, E., additional, and Murru, A., additional
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- 2023
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6. New therapy by surfactant to avoid neuro/psychiatric problems caused by cerebral hypoxia
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Bracco, L., primary
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- 2021
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7. Preventive medicine for anorexia of female adolescent
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Bracco, L., primary
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- 2021
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8. Head and neck squamous cell carcinoma transcriptome analysis by comprehensive validated differential display
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Carles, A, Millon, R, Cromer, A, Ganguli, G, Lemaire, F, Young, J, Wasylyk, C, Muller, D, Schultz, I, Rabouel, Y, Dembélé, D, Zhao, C, Marchal, P, Ducray, C, Bracco, L, Abecassis, J, Poch, O, and Wasylyk, B more...
- Published
- 2006
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9. Metabolic interaction between ApoE genotype and onset age in Alzheimer's disease: implications for brain reserve
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Mosconi, L., Herholz, K., Prohovnik, I., Nacmias, B., De Cristofaro, M.T.R., Fayyaz, M., Bracco, L., Sorbi, S., and Pupi, A.
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Genotype -- Research ,Age factors in disease -- Development and progression ,Age factors in disease -- Medical examination ,Age factors in disease -- Research ,Alzheimer's disease -- Development and progression ,Alzheimer's disease -- Medical examination ,Alzheimer's disease -- Research ,Health ,Psychology and mental health - Published
- 2005
10. Brain metabolic decreases related to the dose of the ApoE e4 allele in Alzheimer's disease
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Mosconi, L., Nacmias, B., Sorbi, S., De Cristofaro, M.T.R., Fayazz, M., Tedde, A., Bracco, L., Herholz, K., and Pupi, A.
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Alzheimer's disease -- Research -- Genetic aspects -- Physiological aspects ,Health ,Psychology and mental health ,Physiological aspects ,Research ,Genetic aspects - Abstract
J Neurol Neurosurg Psychiatry 2004;75:370-376 Objectives: Declines in brain glucose metabolism have been described early in Alzheimer's disease (AD), and there is evidence that a genetic predisposition to AD contributes [...] more...
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- 2004
11. The role of cannabis in bipolar disorder relapse: a prospective study of hospital acute readmissions.
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Olivier, L., Giménez, A., Andreu Gracia, H., Bueno, L., De Juan Viladegut, Ó., Fernández, T. M., Ochandiano, I., Salmerón, S., Bracco, L., Tardón Senabre, L., and Pacchiarotti, I.
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MARIJUANA abuse ,SCHIZOAFFECTIVE disorders ,PATIENT readmissions ,PSYCHIATRIC treatment ,ELECTROCONVULSIVE therapy - Abstract
Introduction: With the rapid changes of attitude, investigation and legislation around cannabis and its subproducts in the Western world, there is a need to profoundly examine the consequences of its use in the general population and, specifically, in people affected by mental disorders. There is a clear relationship between cannabis use and psychosis, but there is also growing evidence of its relationship with manic episodes (Sideli et al, 2019). A systematic review published by the CANMAT Task Force in 2022 examined again the relationship between cannabis use and bipolar disorder (BD), establishing association with worsened course and functioning of BD in frequent users (Tourjman et al., 2023). On the other hand, some recent papers have highlighted the role of the endocannabinoid system (ECS) in BD, suggesting even possible beneficial effects, mainly through the CB2 receptor (Arjmand et al, 2019). Objectives: To describe the impact of cannabis in the psychiatric readmission in BD and to approach the differences in course in cannabis users with regards to non-users. Methods: We conducted a prospective cohort study including the patients admitted to our acute psychiatric unit with the diagnosis of manic or mixed episode during the period between 2015 and 2019 (including patients with one of both final diagnosis: BD or schizoaffective disorder). We established a follow-up of 3 years from the date of admission in which hospital readmissions are examined. Results: The study, which included 309 patients, concluded that cannabis users were admitted and had the first episode at a younger age (p=0.005), a higher percentage of them did not have a previous diagnosis (p=0.026) nor a previous history of mental health issues (p=0.019) and it was more likely to be their first admission (p=0.011) and to suffer psychotic symptoms (p=0.002). As of treatment, the results were statistically significant regarding the fact that a lower proportion of patients had received previous psychiatric treatment (p=0.004) and previous electroconvulsive therapy (p=0.003). There was a higher chance of them being non-adherent with medication (p<0.001) and to be administered extended-release antipsychotic treatment during admission (p<0.001). The study did not find a statistically significant relationship with cannabis use and a higher rate of readmission in the 3 years of follow-up. Conclusions: Although a higher relapse rate could not be proven in our study, other previously identified factors related to a worse illness course (Sajatovic et al., 2009) did show a significant association with cannabis use, which could lead to one suggesting that our results are compatible with the actual evidence and that cannabis products are detrimental to people who suffer from BD and schizoaffective disorder. Disclosure of Interest: None Declared [ABSTRACT FROM AUTHOR] more...
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- 2024
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12. Interplay of Environmental Factors, Genetic Susceptibility, and Sleep Disturbances predict Bipolar Disorder's Relapses: preliminary results from a pilot study.
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Bort, M., Fico, G., Oliva, V., de Prisco, M., Bracco, L., Possidente, C., Rivas, M. Y., Ruiz, V., Montejo, L., Vieta, E., and Murru, A.
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SLEEP interruptions ,AIR pollutants ,METEOROLOGICAL stations ,CIRCADIAN rhythms ,AIR pollution - Abstract
Introduction: Predicting acute affective episodes in individuals with Bipolar Disorder (BD) remains a clinical challenge. Specific environmental stressors, including air pollution, noise, and temperature variations might worsen affective symptoms or sleep in the general population, but their role in BD relapses is often overlooked. Indeed, they might exacerbate BD by perturbing circadian rhythms – fundamental aspects of BD. Objectives: We thereby present the protocol of this pilot study and future preliminary data. We aim to longitudinally assess sleep alterations, mood fluctuations, and environmental exposure to several factors (air pollutants, climate, noise, artificial light-at-night, green space access) in patients with BD and to check the association of these variables with BD relapses. Methods: In this pilot study, we will recruit 40 patients with BD in a 6-month prospective study. Patients were assessed during baseline, at 3 and 6 months. Data recollected will consist of a subjective (questionnaires) and objective (through meteorological stations) evaluation of physical environmental factors around the home residence; clinical assessment of mood and circadian rhythms, and continuous tracking of sleep-wake patterns, energy, and movement using actigraphy. Results: Expected results will show that exposure to a worse environment (higher pollution, noise, light exposure, climate) will be associated with worse BD outcomes (i.e., relapse, mood symptoms, sleep alterations). Conclusions: We will be sharing preliminary data from our ongoing study, offering insights into early patterns and findings that shed light on our objectives. Disclosure of Interest: None Declared [ABSTRACT FROM AUTHOR] more...
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- 2024
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13. The relationship between sleep problems and suicidality in Bipolar Disorder: a Systematic Review and a Meta-analysis.
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Possidente, C., Bort, M., De Prisco, M., Oliva, V., Fico, G., Bracco, L., Sommerhoff, C., Montejo, L., Murru, A., and Vieta, E.
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SLEEP interruptions ,SLEEP ,SLEEP quality ,ATTEMPTED suicide ,SUICIDAL ideation - Abstract
Introduction: Bipolar disorder (BD) is a multifaceted illness encompassing mood, energy, cognitive and biorhythms alterations. Sleep disturbances are common in prodromic, acute and inter-episodic phases of BD. Suicidality presents a known association with sleep disturbances. However, their interplay in BD remains intricate and not fully elucidated. Objectives: The aim of the present systematic review (SR) and meta-analysis (MA) is to summarise the available evidence and to provide an estimate of the association between sleep disturbances and suicidality, defined as presence of suicide ideation, behaviour and suicide attempts, in patients with BD. Methods: We conducted a comprehensive literature search following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines across PubMed, PsycINFO, and SCOPUS databases. We included all studies reporting an association between sleep problems and suicidal behaviour in BD patients. No language restriction was imposed. Effect sizes were calculated as odds ratio (OR) for dichotomic variables, standard mean difference (SMD) for continuous outcomes, and Spearman's coefficient (r) for correlations. Heterogeneity was assessed using the I2 statistic. Global inconsistency was evaluated using the Q statistics with the corresponding p-value. Results: The initial search yielded 911 unique abstracts, of which 62 underwent full-text screening. Fourteen publications were included, comprising twelve cross-sectional and two longitudinal studies. The total sample consisted of 19,601 subjects diagnosed with BD, of which 51.76% were females and 69.52% had a diagnosis of BD type 1. We found that people with BD and sleep disturbances tend to have higher suicidality, both current (SMD=0.79, 95%CI=0.53, 1.05) and lifetime (OR=1.8; 95%CI=1.41, 2.55), when compared with people with BD and no sleep disturbances. Additionally, patients with BD and a history of suicide attempts tend to have more sleep problems (OR=1.37, 95%CI=1.21, 1.55). Moreover, a positive correlation exists between suicidality and poor sleep quality measured by the Pittsburgh Sleep Quality Index (PSQI) (r= 0.24, 95%CI=0.10, 0.36). No heterogeneity was found, except in the subanalysis of correlation (I2=66.67%, Q p-value=0.01). Conclusions: Our SRMA outlines a positive relation between sleep disturbances and suicidality in patients with BD. The small number of included studies and the scarcity of longitudinal studies, preventing the inference of a causal relationship, represent the major limitations of this study. Also, studies with objective measures of sleep alterations are currently lacking. The prompt recognition, objective measurement, and treatment of sleep alterations could be crucial in averting or reducing suicidal attempts in BD. Disclosure of Interest: C. Possidente: None Declared, M. Bort: None Declared, M. De Prisco: None Declared, V. Oliva: None Declared, G. Fico Grant / Research support from: Fellowship from "La Caixa" Foundation (ID 100010434 - fellowship code LCF/BQ/DR21/11880019), L. Bracco: None Declared, C. Sommerhoff: None Declared, L. Montejo: None Declared, A. Murru Grant / Research support from: Spanish Ministry of Science and Innovation (PI19/00672, PI22/00840) integrated into the Plan Nacional de I+D+I and co-financed by the ISCIII-Subdireccion General de Evaluacio ́n and the Fondo Europeo de Desarrollo Regional (FEDER), E. Vieta Grant / Research support from: Spanish Ministry of Science and Innovation (PI18/ 00805, PI21/00787) integrated into the Plan Nacional de I+D+I and cofinanced by the ISCIII-Subdireccio ́n General de Evaluacio ́n and the Fondo Europeo de Desarrollo Regional (FEDER); the Instituto de Salud Carlos III; the CIBER of Mental Health (CIBERSAM); the Secretaria d'Universitats i Recerca del Departament d'Economia i Coneixement (2017 SGR 1365), the CERCA Programme, and the Departament de Salut de la Generalitat de Catalunya for the PERIS grant SLT006/17/00357; the European Union Horizon 2020 research and innovation program (EU.3.1.1. Understanding health, wellbeing and disease: Grant No 754907 and EU.3.1.3. Treating and managing disease: Grant No 945151). [ABSTRACT FROM AUTHOR] more...
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- 2024
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14. Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
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Lambert, J. C., Ibrahim-Verbaas, C. A., Russo, G., Mayhaus, M., Lannefelt, L., Hakonarson, H., Pichler, S., Carrasquillo, M. M., Ingelsson, M., Beekly, D., Alvarez, V., Zou, F., Valladares, O., Thorton-Wells, T. A., Younkin, S. G., Coto, E., Hamilton-Nelson, K. L., Gu, W., Razquin, C., Pastor, P., Mateo, I., Owen, M. J., Faber, K. M., Jonsson, P. V., Jones, N., Combarros, O., O'Donovan, M. C., Cantwell, L. B., Soininen, H., Blacker, D., Mead, S., Mosley, T. H., Bennett, D. A., Harris, T. B., Fratiglioni, L., Smith, A. V., Holmes, C., de Bruijn, R. F., Passmore, P., Montine, T. J., Bettens, K., Rotter, J. I., Brice, A., Morgan, K., Foroud, T. M., Kukull, W. A., Chouraki, V., Hannequin, D., Powell, J. F., Nalls, M. A., Ritchie, K., Lunetta, K. L., Kauwe, J. S., Boerwinkle, E., Riemenschneider, M., Boada, M., Hiltuenen, M., Thomas, C., Martin, E. R., Schmidt, R., Rujescu, D., Wang, L. S., Dartigues, J. F., Mayeux, R., Tzourio, C., Hofman, A., Nöthen, M. M., Graff, C., Ikram, M. A., Psaty, B. M., Jones, L., Haines, J. L., Holmans, P. A., Lathrop, M., Pericak-Vance, M. A., Launer, L. J., Farrer, L. A., van Duijn, C. M., Van Broeckhoven, C., Zelenika, D., Moskvina, V., Seshadri, S., Williams, J., Schellenberg, G. D., Amouyel, P., Alpérovitch, A., Boland, A., Delépoine, M., Dubois, B., Duron, E., Vardarajan, B. N., Epelbaum, J., Van Cauwenberghe, C., Engelborghs, S., Vandenberghe, R., De Deyn, P. P., Ferri, R., Romano, C., Caltagirone, C., Orfei, M. D., Ciaramella, A., Kamatani, Y., Scarpini, E., Fenoglio, C., Siciliano, G., Bonuccelli, U., Bagnoli, S., Bracco, L., Bessi, V., Cecchetti, R., Bastgiani, P., Squassina, A., Harold, D., Lin, C. F., Seripa, D., Frank-García, A., Sastre, I., Blesa, R., Alcolea, D., Suárez-Clavet, M., Sánchez-Juan, P., Muñoz Fernandez, C., Aladro Benito, Y., Thonberg, H., Gerrish, A., Forshell, C., Lilus, L., Kinhult-Ståhlbom, A., Giedraitis, V., Kilander, L., Brundin, R. M., Concari, L., Helisalmi, S., Koivisto, A. M., Haapasalo, A., Schmidt, H., Solfrizzi, V., Frisardi, V., Ott, J., Carney, R. M., Mash, D. C., Albert, M. S., Albin, R. L., Apostolova, L. G., Arnold, S. E., Barmada, M. M., Kunkle, B., Barnes, L. L., Beach, T. G., Bigio, E. H., Bird, T. D., Boeve, B. F., Bowen, J. D., Boxer, A., Burk, J. R., Cairns, N. J., Cao, C., Dunstan, M. L., Carlson, C. S., Carroll, S. L., Chibnik, L. B., Chui, H. C., Clark, D. G., Corneveaux, J., Cribbs, D. G., DeCarli, C., DeKosky, S. T., Demirci, F. Y., Ruiz, A., Dick, M., Dickson, D. W., Duara, R., Ertekin-Taner, N., Fallon, K. B., Farlow, M. R., Ferris, S., Frosch, M. P., Galasko, G. R., Ganguli, M., Bihoreau, M. T., Gearing, M., Geschwind, D. H., Ghetti, B., Gilman, S., Glass, J. D., Growdon, J. H., Hamilton, R. L., Harrell, L. E., Head, E., Honig, L. S., Choi, S. H., Hulette, C. M., Hyman, B. T., Jarvik, G. P., Jicha, G. A., Jin, L. W., Karydas, A., Kaye, J. A., Kim, R., Koo, E. H., Reitz, C., Kowall, N. W., Kramer, J. H., Kramer, P., LaFerla, F. M., Lah, J. J., Levernez, J. B., Levey, A. I., Li, G., Lieberman, A. P., Lyketsos, C. G., Pasquier, F., Mack, W. J., Marson, D. C., Martiniuk, F., Masliah, E., McCormick, W. C., McCurry, S. M., McDavid, A. N., McKee, A. C., Mesulam, M., Miller, B. L., Naj, A. C., Cruchaga, C., Miller, C. A., Miller, J. W., Morris, J. C., Murrell, J. R., Olichney, J. M., Pankratz, V. S., Parasi, J. E., Peskind, E., Peterson, R. C., Pierce, A., Craig, D., Poon, W. W., Potter, H., Quinn, J. F., Raj, A., Raskind, M., Raiman, E. M., Reisberg, B., Ringman, J. M., Roberson, E. D., Rosen, H. J., Amin, N., Rosenberg, R. N., Sano, M., Saykin, A. J., Schneider, J. A., Schneider, L. S., Seely, W. W., Smith, A. G., Sonnen, J. A., Spina, S., Stern, R. A., Berr, C., Tanzi, R. E., Trojanowski, J. Q., Troncoso, J. C., Van Deerlin, V. M., Van Eldik, L. J., Vinters, H. V., Vonsattel, J. P., Weintraub, S., Welsh-Bohmer, K. A., Williamson, J., Lopez, O. L., Woltjer, R. L., Yu, C. E., Barber, R., Au, R., Wolf, P. A., Beiser, A., Debette, S., Yang, Q., Weinstein, G., Johnson, A. D., De Jager, P. L., Wang, J., Uitterlinden, A. G., Rivadeneira, F., Koudstgaal, P. J., Longstreth, W. T., Becker, J. T., Kuller, L. H., Lumley, T., Rice, K., Garcia, M., Deramecourt, V., Aspelund, T., Marksteiner, J. J., Dal-Bianco, P., Töglhofer, A. M., Freudenberger, P., Ransmayr, G., Benke, T., Toeglhofer, A. M., Bressler, J., Breteler, M. M., Johnston, J. A., Fornage, M., Hernández, I., Rosende Roca, M., Ana Mauleón, M., Alegrat, M., RamÍrez-Lorca, R., González-Perez, A., Chapman, J., Stretton, A., Morgan, A., Evans, D., Kehoe, P. G., Medway, C., Lord, J., Turton, J., Hooper, N. M., Vardy, E., Warren, J. D., Schott, J. M., Uphill, J., Ryan, N., Lovestone, S., Rossor, M., Ben-Shlomo, Y., Makrina, D., Gkatzima, O., Lupton, M., Koutroumani, M., Avramidou, D., Germanou, A., Jessen, F., Riedel-Heller, S., Sims, R., Letenneur, L., Dichgans, M., Heun, R., Kölsch, H., Schürmann, B., Herold, C., Lacour, A., Drichel, D., Hoffman, P., Kornhuber, J., Morón, F. J., Feulner, T., van den Bussche, H., Lawlor, B., Lynch, A., Mann, D., Smith, A. D., Warden, D., Wilcock, G., Heuser, I., Wiltgang, J., Rubinsztein, D. C., Frölich, L., Hüll, M., Mayo, K., Livingston, G., Bass, N. J., Gurling, H., McQuillen, A., Gwilliam, R., Deloukas, P., Al-Chalabi, A., Eiriksdottir, G., Shaw, C. E., Singleton, A. B., Guerreiro, R., Jöckel, K. H., Klopp, N., Wichmann, H. E., Graff-Radford, N. R., Ma, L., Bisceglio, G., Sleegers, K., Fisher, E., Warner, N., Pickering-Brown, S., Becker, Tim, Goate, A. M., Fiévet, N., Huentelman, M. W., Gill, M., Brown, K., Bellenguez, C., Kamboh, M. I., Keller, L., Barberger-Gateau, P., McGuiness, B., Larson, E. B., Green, R., Myers, A. J., Dufouil, C., Todd, S., Wallon, D., DeStafano, A. L., Love, S., Rogaeva, E., Gallacher, J., St George-Hyslop, P., Clarimon, J., Lleo, A., Bayer, A., Tsuang, D. W., Yu, L., Tsolaki, M., Bis, J. C., Bossù, P., Spalletta, G., Proitsi, P., Collinge, J., Sorbi, S., Sanchez-Garcia, F., Fox, N. C., Hardy, J., Deniz Naranjo, M. C., Bosco, P., Beecham, G. W., Clarke, R., Brayne, C., Galimberti, D., Mancuso, M., Matthews, F., Initiative, European Alzheimer's Disease, Disease, Genetic and Environmental Risk in Alzheimer's, Consortium, Alzheimer's Disease Genetic, Epidemiology, Cohorts for Heart and Aging Research in Genomic, Moebus, S., Grenier-Boley, B., Mecocci, P., Del Zompo, M., Maier, W., Hampel, H., Pilotto, A., Bullido, M., Panza, F., Caffarra, P., Nacmias, B., Gilbert, J. R., Neurology, Radiology & Nuclear Medicine, and Epidemiology more...
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Male ,Apolipoprotein E ,epidemiology [Alzheimer Disease] ,SORL1 ,Medizin ,genetics [Alzheimer Disease] ,Genome-wide association study ,Single-nucleotide polymorphism ,Biology ,Polymorphism, Single Nucleotide ,Article ,PICALM ,Cohort Studies ,Alzheimer Disease ,ddc:570 ,PSEN2 ,Genetics ,medicine ,Humans ,Genetic Predisposition to Disease ,Age of Onset ,Aged ,Genetic association ,Aged, 80 and over ,Middle Aged ,medicine.disease ,Genetic Loci ,Case-Control Studies ,Female ,Human medicine ,Alzheimer's disease ,statistics & numerical data [Genome-Wide Association Study] ,Genome-Wide Association Study - Abstract
Eleven susceptibility loci for late-onset Alzheimer's disease (LOAD) were identified by previous studies; however, a large portion of the genetic risk for this disease remains unexplained. We conducted a large, two-stage meta-analysis of genome-wide association studies (GWAS) in individuals of European ancestry. In stage 1, we used genotyped and imputed data (7,055,881 SNPs) to perform meta-analysis on 4 previously published GWAS data sets consisting of 17,008 Alzheimer's disease cases and 37,154 controls. In stage 2, 11,632 SNPs were genotyped and tested for association in an independent set of 8,572 Alzheimer's disease cases and 11,312 controls. In addition to the APOE locus (encoding apolipoprotein E), 19 loci reached genome-wide significance (P < 5 x 10(-8)) in the combined stage 1 and stage 2 analysis, of which 11 are newly associated with Alzheimer's disease. more...
- Published
- 2013
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15. MCI conversion to dementia and the Apoe genotype: a prediction study with FDG-PET
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Mosconi, L., Perani, D., Sorbi, S., Herholz, K., Nacmias, B., Holthoff, V., Salmon, E., jean-claude baron, Cristofaro, M. T. R., Padovani, A., Borroni, B., Franceschi, M., Bracco, L., Pupi, A., Mosconi, L, Perani, DANIELA FELICITA L., Sorbi, S, Herholz, K, Nacmias, B, Holthoff, V, Salmon, E, Baron, Jc, De Cristofaro, Mtr, Padovani, A, Borroni, B, Franceschi, M, Bracco, L, and Pupi, A. more...
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APOE genotype ,FDG-PET ,MCI - Published
- 2004
16. How legislation on decisional capacity can negatively affect the feasibility of clinical trials in patients with dementia
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Galeotti, F, Vanacore, N, Gainotti, S, Izzicupo, F, Menniti Ippolito, F, Petrini, C, Chiarotti, F, Chattat, R, Raschetti, R, AdCare Study Group: Popoli, P, Potenza, R, Tebano, Mt, Giubilei, F, Locuratolo, N, Bruno, G, Piacentini, E, Talarico, G, Gasparini, M, Del Re ML, Bruni, A, Colao, R, Puccio, G, Curcio, S, Clodimiro, A, Caffarra, P, Messa, G, Concari, L, Pagliara, B, Fabbo, A, Zucchi, P, Bonora, A, Veschi, M, Carbone, G, Ursino, R, Fatica, L, De Bonis, C, Gainotti, G, Marra, C, Quaranta, D, Zinno, M, Rodriguez, Guido, Nobili, FLAVIO MARIANO, Barbieri, Mp, Dessi, B, Mazzei, D, Arnaldi, Dario, Brugnolo, Andrea, Clerici, F, Mariani, C, Maggiore, L, Pomati, S, Padovani, A, Rozzini, L, Zanetti, M, Conti, M, Chinaglia, C, Engaddi, I, De Domenico, D, Savorgnan, G, Scarpino, O, Civerchia, P, Raccichini, A, Specchio, Lm, Goffredo, R, Biancardi, Me, Putzu, V, Araujo, Y, Ballisai, A, Piras, Mr, Cherchi, R, Bagella, Cf, Deiana, E, Giordano, M, Pineo, A, Catania, Tm, Bracco, L, Piccini, C, Mecocci, P, Feliziani, Ft, Cornacchiola, V, Gambina, G, Broggio, E, Sala, F., Galeotti F, Vanacore N, Gainotti S, Izzicupo F, Menniti-Ippolito F, Petrini C, Chiarotti F, Chattat R, Raschetti R, and AdCare Study Group more...
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Olanzapine ,medicine.medical_specialty ,medicine.drug_class ,medicine.medical_treatment ,Decision Making ,Atypical antipsychotic ,law.invention ,Randomized controlled trial ,Informed consent ,law ,Humans ,Medicine ,Mental Competency ,Pharmacology (medical) ,Antipsychotic ,Psychiatry ,legal ,Clinical Trials as Topic ,Risperidone ,business.industry ,Patient Selection ,CAPACITY, BPSD ,antipsychotic ,Clinical trial ,Settore MED/26 - NEUROLOGIA ,Feasibility Studies ,Quetiapine ,Dementia ,Geriatrics and Gerontology ,business ,medicine.drug - Abstract
Antipsychotic drugs are widely used to treat behavioural and psychological disturbances associated with Alzheimer's disease (AD), although only modest evidence from randomized controlled trials supports their efficacy, and increasing evidence from post-marketing surveillance shows serious adverse events associated with their use, including increased mortality. The AdCare study, a non-profit, randomized, placebo-controlled, double-blind, multicentre, pragmatic trial coordinated by the Italian National Institute of Health, aimed to evaluate the long-term safety and efficacy profiles of three atypical antipsychotic drugs (risperidone, olanzapine and quetiapine) and one conventional antipsychotic drug (haloperidol) in treating psychosis, aggression and agitation in outpatients with AD. The study was planned to be carried out in 19 clinical centres and to enrol 1000 outpatients. According to Italian law, in the case where a patient is considered unable to give informed consent, a legal representative designated by the court has to provide it. Because of difficulties in the informed consent procedure, the study had to be prematurely interrupted. From February 2009 to April 2010, 83 patients gave informed consent to participate in the trial. Fifty-six patients (68%) were included with consent given by a legal representative, while 27 patients (32%) were considered to provide personal informed consent on the basis of the results from a specifically built procedure. Patients and caregivers were offered the opportunity to participate in the trial before the occurrence of behavioural disturbances, in order to provide them with enough time to consider their participation in the study. Twenty-three patients experienced behavioural, clinically relevant symptoms and were randomized to the study drug; all randomized patients except one had consent for inclusion in the study given by legal representatives. After trial interruption, all patients taking an active drug continued treatment with the same molecule in clinical practice. Randomized controlled trials are acknowledged as the gold standard source of evidence on drug safety and efficacy. The AdCare study showed that an excessively rigid regulation can become a major obstacle while carrying out therapeutic research with incapacitated persons. more...
- Published
- 2012
17. AD: role of clinical examinations in predicting neurpathological features
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Campani D, Marcon G, Bracco L, Simonati A, Rizzuto N, Piccininni M, Piccini D, Manfredi G, Falcini M, Notarelli A, Amaducci L, Campani, D, Marcon, G, Bracco, L, Simonati, A, Rizzuto, N, Piccininni, M, Piccini, D, Manfredi, G, Falcini, M, Notarelli, A, and Amaducci, L more...
- Published
- 1995
18. Clinico-Neuropathological correlations in AD
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Campani, D, Bracco, L, Marcon, G, Simonati, A, Rizzuto, N, Campani, D, Bracco, L, Marcon, G, Simonati, A, and Rizzuto, N
- Published
- 1995
19. FACTORS AFFECTING COURSE AND SURVIVAL IN ALZHEIMERS-DISEASE - A 9-YEAR LONGITUDINAL-STUDY
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Bracco, L, Gallato, R, Grigoletto, F, Lippi, A, Lepore, V, Bino, G, Lazzaro, Mp, Carella, F, Piccolo, T, Pozzilli, C, Giometto, B, Amaducci, L, Bracco, L, Gallato, R, Grigoletto, F, Lippi, A, Lepore, V, Bino, G, Lazzaro, Mp, Carella, F, Piccolo, T, Pozzilli, C, Giometto, B, and Amaducci, L more...
- Abstract
Objective: To evaluate mean survival and to identify prognostic factors in a cohort of patients with Alzheimer's disease (AD). Design: Multicentric 9-year cohort analytic study. Setting: Seven neurology departments throughout Italy between April 1982 and January 1984. Patients: We recruited a consecutive sample of 145 patients affected by probable AD (Multicenter Italian Study on Dementia protocol, National Institute of Neurological Disorders and Stroke-Alzheimer's Disease and Related Disorders Association criteria). Five were misdiagnosed, and 21 could not participate in the longitudinal study. The clinicodemographic characteristics of the 119 enrolled patients (49 men, 70 women; mean age, 64.7 years; SD, 4.1 years; mean duration of disease, 3.1 years; SD, 1.8 years) did not differ from those of the 26 excluded patients. All underwent extensive cliniconeuropsychological testing every 6 months for at least 2 years until the patient died or our survey ended (April 30, 1991). Mean follow-up was 5.1 years (SD, 2.5 years). Main Outcome Measures: Death, severe functional impairment (a score greater than or equal to 7 on the Blessed Dementia Scale),and severe cognitive impairment (a score of less than or equal to 7 on the Information-Memory-Concentration Test). Results: Survival curves obtained by the Kaplan-Meier method indicated that (1) patients with early- and late-onset disease tie, before or after age 65 years) showed no difference either in relative survival or in time to reach predetermined functional and cognitive end points; (2) severely aphasic patients became profoundly demented significantly sooner than those with mild to moderate aphasia (P more...
- Published
- 1994
20. Clinical – neuropathological correlations in Alzheimer’s disease: description of seven cases
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Bracco L, Campani D, Piccini D, Simonati A, Marcon G, Rizzuto N, Bracco, L, Campani, D, Piccini, D, Simonati, A, Marcon, G, and Rizzuto, N
- Published
- 1993
21. SURVIVAL IN SENILE AND PRESENILE ALZHEIMERS-DISEASE
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BRACCO L, LIPPI A, AMADUCCI L, GALLATO R, GRIGOLETTO F, TERME A, PEDONE D, LIVREA P, BINO G, TABATON M, MORETTI C, LOEB C, BONATTI ML, CAMPANOZZI F, PRENCIPE M, PICCOLO T, CARACENI T, GIOMETTO B, TAVOLATO B, BATTISTIN L, DANTONA R, FIESCHI C, Bracco, L, Lippi, A, Amaducci, L, Gallato, R, Grigoletto, F, Terme, A, Pedone, D, Livrea, P, Bino, G, Tabaton, M, Moretti, C, Loeb, C, Bonatti, Ml, Campanozzi, F, Prencipe, M, Piccolo, T, Caraceni, T, Giometto, B, Tavolato, B, Battistin, L, Dantona, R, and Fieschi, C more...
- Published
- 1990
22. Regional Analysis of the Magnetization Transfer Ratio of the Brain in Mild Alzheimer Disease and Amnestic Mild Cognitive Impairment
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Mascalchi, M., primary, Ginestroni, A., additional, Bessi, V., additional, Toschi, N., additional, Padiglioni, S., additional, Ciulli, S., additional, Tessa, C., additional, Giannelli, M., additional, Bracco, L., additional, and Diciotti, S., additional more...
- Published
- 2013
- Full Text
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23. La valutazione neuropatologica nella malattia di Alzheimer (AD): correlazioni con il quadro clinico ed analisi delle problematiche
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Campani, D., Bracco, L., Marcon, G., Simonati, Alessandro, Rizzuto, Nicolo', Piccini, C., and Amaducci, L.
- Published
- 1996
24. Validation of the Guidelines for the Diagnosis of Dementia and Alzheimer's Disease of the Italian Neurological Society. Study in 72 Italian neurological centres and 1549 patients
- Author
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Musicco, M, Sorbi, S, Bonavita, V, Caltagirone, C, Aguglia, U, Burzomati, D, Appollonio, I, Isella, V, Bergamasco, B, Ferrero, P, Rota, E, Bergonzi, P, Cancelli, I, Bertolani, L, Bionda, E, Strumia, S, Palazzini, E, Fragazzi, A, Bono, G, Bonuccelli, U, Cipriani, G, Agostini, S, Bracco, L, Bessi, V, Bruni, A, Curcio, S, Puccio, G, Caffarra, P, Messa, G, Vezzadini, G, Perri, R, Scalmana, S, Canal, N, Alberoni, M, Mantovani, F, Farina, E, Pinardi, G, Cannatà, A, Cappa, S, Marcone, A, Casale, R, Fundarò, C, Comi, G, Magnani, G, Coppola, G, De Leo, M, Vasquez, A, Cossa, F, Simone, P, Sinforiani, E, Tabaton, M, Giliberto, L, Tanganelli, P, Partinico, D, Tola, M, Toso, V, Billo, G, Sgaramella, T, Parisen, P, Valluzzi, F, Zaccara, G, Piccininni, M, Zagnoni, P, Peano, M, Carena, G, Tommaso, B, Francesco, P, Sorbi, S., APPOLLONIO, ILDEBRANDO, ISELLA, VALERIA, Bruni, AC, De Leo, MS, Francesco, P., Musicco, M, Sorbi, S, Bonavita, V, Caltagirone, C, Aguglia, U, Burzomati, D, Appollonio, I, Isella, V, Bergamasco, B, Ferrero, P, Rota, E, Bergonzi, P, Cancelli, I, Bertolani, L, Bionda, E, Strumia, S, Palazzini, E, Fragazzi, A, Bono, G, Bonuccelli, U, Cipriani, G, Agostini, S, Bracco, L, Bessi, V, Bruni, A, Curcio, S, Puccio, G, Caffarra, P, Messa, G, Vezzadini, G, Perri, R, Scalmana, S, Canal, N, Alberoni, M, Mantovani, F, Farina, E, Pinardi, G, Cannatà, A, Cappa, S, Marcone, A, Casale, R, Fundarò, C, Comi, G, Magnani, G, Coppola, G, De Leo, M, Vasquez, A, Cossa, F, Simone, P, Sinforiani, E, Tabaton, M, Giliberto, L, Tanganelli, P, Partinico, D, Tola, M, Toso, V, Billo, G, Sgaramella, T, Parisen, P, Valluzzi, F, Zaccara, G, Piccininni, M, Zagnoni, P, Peano, M, Carena, G, Tommaso, B, Francesco, P, Sorbi, S., APPOLLONIO, ILDEBRANDO, ISELLA, VALERIA, Bruni, AC, De Leo, MS, and Francesco, P. more...
- Abstract
The objective of this study was to verify the adherence of Italian family physicians and neurologists to the Guidelines on Diagnosis of Dementia of the Italian Society of Neurology. A multicentre survey was carried out, in 72 neurological centres. The centres included at least 15 consecutive subjects suspected of having a dementia. The adherence of family physicians to the guidelines was poor. Neurologists performed a complete neuropsychological evaluation in a minority of the cases. Patients who had a decrease of Mini Mental Status Examination scores after six months higher than or equal to 4 were more represented among those patients for whom one or more recommendations were not respected. In Italy the adherence to the Guidelines on Diagnosis of Dementia and Alzheimer Validation studys Disease of the Italian Society of Neurology is very poor for family physicians (GPs) and satisfactory, albeit improvable, on the part of neurologists. Respect for the guidelines might improve the outcome of patients with dementia. © Springer-Verlag Italia 2004. more...
- Published
- 2004
25. Resonance Energy Transfer in the Solution Phase Photophysics of −Re(CO)3L+ Pendants Bonded to Poly(4-vinylpyridine)
- Author
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Bracco, L. L. B., primary, Juliarena, M. P., additional, Ruiz, G. T., additional, Féliz, M. R., additional, Ferraudi, G. J., additional, and Wolcan, E., additional
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- 2008
- Full Text
- View/download PDF
26. Guidelines for the diagnosis of dementia and Alzheimer's disease
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Sorbi, S, Alberoni, M, Alfieri, P, Amici, S, Antana, D, Appollonio, I, Avanzi, S, Bartoli, A, Bergamasco, B, Bracco, L, Bruni, A, Bugiani, O, Caffarra, P, Caltagirone, C, Carolei, A, Rosa, A, Ciannella, L, Citterio, A, Daniele, A, D'Achille, G, Del Curatolo, G, Dell'Agnello, G, Durante, D, Farina, E, Ferrero, P, Forleo, P, Gainotti, G, Gabriele, P, Galante, E, Gallai, V, Gallassi, R, Gasparini, M, Ghetti, B, Giaccone, G, Girotti, F, Grimaldi, L, Grioli, S, Guarnieri, B, Grottoli, S, Iemolo, F, Latorraca, S, Le Pira, F, Lenzi, G, Lorusso, S, Mariani, C, Marcon, G, Mascia, V, Mearelli, S, Morante, M, Morbin, M, Musicco, M, Nardelli, E, Nichelli, P, Padovani, A, Paganini, M, Pantieri, R, Parisen, P, Parnetti, L, Passerella, B, Pettenati, C, Piacentini, S, Piccoli, F, Piccolini, C, Pizzolato, G, Provinciali, L, Pugliese, N, Redi, F, Ruggieri, R, Ruggiero, U, Saetta, M, Schoenuber, R, Silveri, M, Sorrentino, G, Sucapane, P, Stracciari, A, Tabaton, M, Tagliavini, F, Toso, V, Valluzzi, F, Guarnieri, BM, Lenzi, GL, Ruggieri, RM, Silveri, MC, Sorbi, S, Alberoni, M, Alfieri, P, Amici, S, Antana, D, Appollonio, I, Avanzi, S, Bartoli, A, Bergamasco, B, Bracco, L, Bruni, A, Bugiani, O, Caffarra, P, Caltagirone, C, Carolei, A, Rosa, A, Ciannella, L, Citterio, A, Daniele, A, D'Achille, G, Del Curatolo, G, Dell'Agnello, G, Durante, D, Farina, E, Ferrero, P, Forleo, P, Gainotti, G, Gabriele, P, Galante, E, Gallai, V, Gallassi, R, Gasparini, M, Ghetti, B, Giaccone, G, Girotti, F, Grimaldi, L, Grioli, S, Guarnieri, B, Grottoli, S, Iemolo, F, Latorraca, S, Le Pira, F, Lenzi, G, Lorusso, S, Mariani, C, Marcon, G, Mascia, V, Mearelli, S, Morante, M, Morbin, M, Musicco, M, Nardelli, E, Nichelli, P, Padovani, A, Paganini, M, Pantieri, R, Parisen, P, Parnetti, L, Passerella, B, Pettenati, C, Piacentini, S, Piccoli, F, Piccolini, C, Pizzolato, G, Provinciali, L, Pugliese, N, Redi, F, Ruggieri, R, Ruggiero, U, Saetta, M, Schoenuber, R, Silveri, M, Sorrentino, G, Sucapane, P, Stracciari, A, Tabaton, M, Tagliavini, F, Toso, V, Valluzzi, F, Guarnieri, BM, Lenzi, GL, Ruggieri, RM, and Silveri, MC more...
- Published
- 2000
27. Head and neck squamous cell carcinoma transcriptome analysis by comprehensive validated differential display
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Carles, A, primary, Millon, R, additional, Cromer, A, additional, Ganguli, G, additional, Lemaire, F, additional, Young, J, additional, Wasylyk, C, additional, Muller, D, additional, Schultz, I, additional, Rabouel, Y, additional, Dembélé, D, additional, Zhao, C, additional, Marchal, P, additional, Ducray, C, additional, Bracco, L, additional, Abecassis, J, additional, Poch, O, additional, and Wasylyk, B, additional more...
- Published
- 2005
- Full Text
- View/download PDF
28. Loss of HOP tumour suppressor expression in head and neck squamous cell carcinoma
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Lemaire, F, primary, Millon, R, additional, Muller, D, additional, Rabouel, Y, additional, Bracco, L, additional, Abecassis, J, additional, and Wasylyk, B, additional
- Published
- 2004
- Full Text
- View/download PDF
29. Differential expression profiling of head and neck squamous cell carcinoma (HNSCC)
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Lemaire, F, primary, Millon, R, additional, Young, J, additional, Cromer, A, additional, Wasylyk, C, additional, Schultz, I, additional, Muller, D, additional, Marchal, P, additional, Zhao, C, additional, Melle, D, additional, Bracco, L, additional, Abecassis, J, additional, and Wasylyk, B, additional more...
- Published
- 2003
- Full Text
- View/download PDF
30. CTS1: a p53-derived chimeric tumor suppressor gene with enhanced in vitro apoptotic properties.
- Author
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Conseiller, E, primary, Debussche, L, additional, Landais, D, additional, Venot, C, additional, Maratrat, M, additional, Sierra, V, additional, Tocque, B, additional, and Bracco, L, additional
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- 1998
- Full Text
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31. Functional interactions between p53 and the TFIIH complex are affected by tumour-associated mutations.
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Léveillard, T., primary, Andera, L., additional, Bissonnette, N., additional, Schaeffer, L., additional, Bracco, L., additional, Egly, J. M., additional, and Wasylyk, B., additional
- Published
- 1996
- Full Text
- View/download PDF
32. Satellite Services In Chicago And the Midwest
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Bracco, L.
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Telecommunications Services Industry ,United States ,Illinois ,Satellite Communications ,Telecommunications ,Teleconferencing ,Communications Equipment - Published
- 1983
33. Synthetic curved DNA sequences can act as transcriptional activators in Escherichia coli.
- Author
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Bracco, L., Kotlarz, D., Kolb, A., Diekmann, S., and Buc, H.
- Abstract
Can a transcriptional activator known to bend DNA be functionally replaced by a sequence‐directed bend in Escherichia coli? To investigate this question, a partially truncated promoter was used, deleted of its ‐35 region and of its CRP binding site, leaving only two Pribnow boxes as functional elements. Synthetic and naturally occurring curved DNA sequences introduced upstream from these elements could restore transcription at either one of the two natural starts. Some of these hybrid promoters turned out to be more efficient than the CRP activated wild‐type gal promoter in vivo. Control experiments performed with very similar sequences devoid of any curvature produced weak promoters only. Minimal changes in the location of the centre of curvature or perturbation in the amount of curvature strongly affected the level of expression. No significant stimulation of transcription could be detected in vitro. Furthermore, both gal P1 and P2 starts could be activated in vivo but also in vitro via a properly positioned CRP binding site. This partial analogy suggests that bending induced by the cAMP‐CRP complex upon binding to its site may be biologically relevant to the mechanism of transcriptional activation. more...
- Published
- 1989
- Full Text
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34. Proteolysis by calpains: a possible contribution to degradation of p53
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Pariat, M, Carillo, S, Molinari, M, Salvat, C, Debüssche, L, Bracco, L, Milner, J, and Piechaczyk, M
- Abstract
p53 is a short-lived transcription factor that is frequently mutated in tumor cells. Work by several laboratories has already shown that the ubiquitin-proteasome pathway can largely account for p53 destruction, at least under specific experimental conditions. We report here that, in vitro, wild-type p53 is a sensitive substrate for milli- and microcalpain, which are abundant and ubiquitous cytoplasmic proteases. Degradation was dependent on p53 protein conformation. Mutants of p53 with altered tertiary structure displayed a wide range of susceptibility to calpains, some of them being largely resistant to degradation and others being more sensitive. This result suggests that the different mutants tested here adopt slightly different conformations to which calpains are sensitive but that cannot be discriminated by using monoclonal antibodies such as PAb1620 and PAb240. Inhibition of calpains by using the physiological inhibitor calpastatin leads to an elevation of p53 steady-state levels in cells expressing wild-type p53. Conversely, activation of calpains by calcium ionophore led to a reduction of p53 in mammalian cells, and the effect was blocked by cell-permeant calpain inhibitors. Cotransfection of p53-null cell lines with p53 and calpastatin expression vectors resulted in an increase in p53-dependent transcription activity. Taken together, these data support the idea that calpains may also contribute to the regulation of wild-type p53 protein levels in vivo. more...
- Published
- 1997
- Full Text
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35. Altered Cro repressors from engineered mutagenesis of a synthetic cro gene.
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Eisenbeis, S J, Nasoff, M S, Noble, S A, Bracco, L P, Dodds, D R, and Caruthers, M H
- Abstract
A portion of the gene coding for the Cro repressor protein of bacteriophage lambda has been chemically synthesized, incorporating base pair changes that generate restriction endonuclease sites without altering the amino acid coding sequence. These restriction endonuclease sites were used to remove small segments of the synthetic cro gene and the segments were replaced with duplexes carrying desired mutations. Altered Cro proteins produced by mutants constructed in this manner were then assayed for binding to lambda operator OR3 in vivo. Mutations directed into the region of the cro gene encoding the alpha-3 helix produced altered Cro proteins with a range of affinities for operator DNA. These changes suggest which amino acids play an important role in Cro-OR3 complex formation. more...
- Published
- 1985
- Full Text
- View/download PDF
36. Clutter analysis to monitor the stabillity of a portable X-band mini weather radar
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Silvano Bertoldo, Bracco, L., Notarpietro, Riccardo, Branca, Marco Andrea Luca, Gabella, Marco, Lucianaz, Claudio, Rorato, Oscar, Allegretti, Marco, and Perona, Giovanni Emilio
- Subjects
clutter echoes ,weather radar ,ground clutter ,rain monitoring ,X-band radar ,X-band ,stability ,precipitation
37. Italian Neurological Society guidelines for the diagnosis of dementia: Revision l
- Author
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Musico, M., Caltagirone, C., Sorbi, S., Bonavita, V., Alberoni, M., Alfieri, P., Altavista, M. C., Amici, S., Antana, D., ILDEBRANDO APPOLLONIO, Avanzi, S., Bartolini, M., Bergamasco, B., Blundo, C., Bonavia, V., Bonuccelli, U., Cipriani, G., Bracco, L., Bruni, A. C., Bugiani, O., Caffara, P., Perri, R., Camarda, R., Canal, N., Cannatà, A., Cantone, G., Carabelli, E., Cardei, A., Carlomagno, S., Casini, A. R., Cheldi, A., Cannnella, L., Citterio, A., Daniele, A., D Anna, S., Del Curatolo, G., Del Pesce, M., Aversana, R., Farina, E., Fasanaro, A. M., Franceschi, M., Gabriele, P., Gainotti, G., Galante, E., Gallai, V., Gallasi, R., Bambina, S., Gasparini, M., Giaccone, G., Giubilei, F., Grassi, M. P., Grimaldi, L., Grioli, S., Bianca, S. G., Guarnirei, M., Batoli, A., Jandolo, B., Temolo, F., La Stilla, M., Latino, R. R., Lenzi, G. L., Lorusso, S., Magnani, G., Malaga, S., Manfredi, L., Marcon, G., Marcore, A., Mariani, C., Mearelli, S., Minore, A., Moleri, M., Morante, M., Morbin, M., Moretti, P., Murri, L., Rognoni, G., Musicco, M., Nichelli, P., Paciello, M., Padovani, A., Paganini, M., Pantieri, R., Parisen, P., Parnetti, L., Partitico, D., Pasquale, S., Passerella, B., Perini, M., Pettinati, C., Piacentini, S., Piccoli, F., Piccolini, C., Pinardi, G., Piras, M. R., Cerchi, R., Principe, M., Provinciali, L., Pugliese, N., Musicco M., Caltagirone C., Sorbi S., Bonavita V., and Gallassi R. more...
- Subjects
Neurologic Examination ,medicine.medical_specialty ,business.industry ,Linee guida ,Malattia di Alzheimer ,Diagnosi ,Demenza ,Dermatology ,General Medicine ,medicine.disease ,Psychiatry and Mental health ,Italy ,Neurology ,Medical ,mental disorders ,medicine ,Dementia ,Humans ,Settore MED/26 - Neurologia ,Neurology (clinical) ,Psychiatry ,business ,Societies ,Societies, Medical - Abstract
The objective of this study was to verify the adherence of Italian family physicians and neurologists to the Guidelines on Diagnosis of Dementia of the Italian Society of Neurology. A multicentre survey was carried out, in 72 neurological centres. The centres included at least 15 consecutive subjects suspected of having a dementia. The adherence of family physicians to the guidelines was poor. Neurologists performed a complete neuropsychological evaluation in a minority of the cases. Patients who had a decrease of Mini Mental Status Examination scores after six months higher than or equal to 4 were more represented among those patients for whom one or more recommendations were not respected. In Italy the adherence to the Guidelines on Diagnosis of Dementia and AlzheimerValidation studys Disease of the Italian Society of Neurology is very poor for family physicians (GPs) and satisfactory, albeit improvable, on the part of neurologists. Respect for the guidelines might improve the outcome of patients with dementia. more...
- Full Text
- View/download PDF
38. High resolution analysis of the human transcriptome: detection of extensive alternative splicing independent of transcriptional activity
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Rouet Fabien, Beurdeley Pascale, Pallares Diego, Lei Lin, Wu Darong, Johnson Seth, Brenner Michael, Jordan Heather, Calciano Margaret A, Zhou Weiyin, Gill Pritmohinder S, Bracco Laurent, Soucaille Cyril, and Einstein Richard more...
- Subjects
Genetics ,QH426-470 - Abstract
Abstract Background Commercially available microarrays have been used in many settings to generate expression profiles for a variety of applications, including target selection for disease detection, classification, profiling for pharmacogenomic response to therapeutics, and potential disease staging. However, many commercially available microarray platforms fail to capture transcript diversity produced by alternative splicing, a major mechanism for driving proteomic diversity through transcript heterogeneity. Results The human Genome-Wide SpliceArray™ (GWSA), a novel microarray platform, utilizes an existing probe design concept to monitor such transcript diversity on a genome scale. The human GWSA allows the detection of alternatively spliced events within the human genome through the use of exon body and exon junction probes to provide a direct measure of each transcript, through simple calculations derived from expression data. This report focuses on the performance and validation of the array when measured against standards recently published by the Microarray Quality Control (MAQC) Project. The array was shown to be highly quantitative, and displayed greater than 85% correlation with the HG-U133 Plus 2.0 array at the gene level while providing more extensive coverage of each gene. Almost 60% of splice events among genes demonstrating differential expression of greater than 3 fold also contained extensive splicing alterations. Importantly, almost 10% of splice events within the gene set displaying constant overall expression values had evidence of transcript diversity. Two examples illustrate the types of events identified: LIM domain 7 showed no differential expression at the gene level, but demonstrated deregulation of an exon skip event, while erythrocyte membrane protein band 4.1 -like 3 was differentially expressed and also displayed deregulation of a skipped exon isoform. Conclusion Significant changes were detected independent of transcriptional activity, indicating that the controls for transcript generation and transcription are distinct, and require novel tools in order to detect changes in specific transcript quantity. Our results demonstrate that the SpliceArray™ design will provide researchers with a robust platform to detect and quantify specific changes not only in overall gene expression, but also at the individual transcript level. more...
- Published
- 2009
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39. The Mixed Tendency in Bipolar Disorder: An Operational Proposal for the Integration of Mixed Episodes in Predominant Polarity.
- Author
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Fico G, Anmella G, De Prisco M, Oliva V, Possidente C, Bracco L, Bort M, Fernandez-Plaza T, Giménez-Palomo A, Vieta E, and Murru A
- Abstract
Predominant Polarity (PP) is an established specifier of Bipolar Disorder (BD), holding significant clinical implications. Nevertheless, there exists no consensus on how to incorporate mixed states into PP, leaving patients prone to mixed recurrences that are unclassified. In a comprehensive study involving 701 euthymic BD patients, we sought to redefine PP by introducing a novel metric, the "mixed tendency", and establish a practical threshold to identify patients with a "mixed phenotype". Furthermore, we investigated potential associations between the mixed phenotype and specific PP categories. Our findings revealed that the mixed tendency correlated significantly with early BD type I, lifetime suicide attempts, self-aggressive behaviour, and lifetime number of affective episodes (>5). Using a ROC curve analysis, we determined an optimal cut-off point for the mixed tendency at 0.228, suggesting that patients with ~25% of lifetime mixed episodes relative to total affective episodes should be identified as having a mixed phenotype. Notably, the mixed phenotype was positively associated with undetermined PP and negatively with manic and depressive PP. This study introduces a promising approach to incorporating mixed episodes into the PP definition, potentially enabling tailored interventions for patients with a substantial history of mixed episodes. However, further research in large, longitudinal cohorts is essential to validate these findings. more...
- Published
- 2023
- Full Text
- View/download PDF
40. Tango-therapy vs physical exercise in older people with dementia; a randomized controlled trial.
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Bracco L, Pinto-Carral A, Hillaert L, and Mourey F
- Subjects
- Humans, Aged, Aged, 80 and over, Postural Balance, Quality of Life, Time and Motion Studies, Exercise, Gait, Exercise Therapy, Activities of Daily Living, Alzheimer Disease
- Abstract
Background: Dementia is a growing health concern that affects millions of people worldwide. Gait and mobility disorders are often present and represent a major risk factor for falls. The purpose of this study was to investigate the effectiveness of tango-therapy in gait speed, functional mobility, balance, falls, ability to perform activities of daily living and quality of life., Methods: A randomised controlled trial with 31 participants living in a specialised dementia unit, aged 65 to 93 years old, who were randomly assigned to tango group (IG) or physical exercise group (CG). The primary outcome was gait speed and Timed Up and Go test. The secondary outcomes include the Short Physical Performance Battery, the ability to perform activities of daily living (Katz Index) and quality of life (Quality of life in Alzheimer Disease). Measurements were performed at baseline, and after one and three months of training., Results: After 3 months, IG improved gait speed (p = 0.016), implying a statistically significant difference between groups in favour of IG (p = 0.003). CG significantly worsened the time to complete the TUG (p = 0.039). Both groups declined in their ability to perform activities of daily living, being statistically significant only in the CG (p < 0.001)., Conclusion: Tango interventions showed efficacy in improving gait speed and in mitigating the decline in functional mobility and ADL skill capacities. Allowing older people with dementia access to non-pharmacological interventions may be a successful strategy to prevent functional decline., Trial Registration: Registered at ClinicalTrials.gov (ID: NCT05744011)., (© 2023. BioMed Central Ltd., part of Springer Nature.) more...
- Published
- 2023
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41. The Trypanosoma cruzi Antigen and Epitope Atlas: antibody specificities in Chagas disease patients across the Americas.
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Ricci AD, Bracco L, Salas-Sarduy E, Ramsey JM, Nolan MS, Lynn MK, Altcheh J, Ballering GE, Torrico F, Kesper N, Villar JC, Marcipar IS, Marco JD, and Agüero F
- Subjects
- Humans, Epitopes, Antibody Specificity, Enzyme-Linked Immunosorbent Assay, Antigens, Protozoan genetics, Antibodies, Americas, Antibodies, Protozoan, Trypanosoma cruzi genetics, Chagas Disease parasitology
- Abstract
During an infection the immune system produces pathogen-specific antibodies. These antibody repertoires become specific to the history of infections and represent a rich source of diagnostic markers. However, the specificities of these antibodies are mostly unknown. Here, using high-density peptide arrays we examined the human antibody repertoires of Chagas disease patients. Chagas disease is a neglected disease caused by Trypanosoma cruzi, a protozoan parasite that evades immune mediated elimination and mounts long-lasting chronic infections. We describe a proteome-wide search for antigens, characterised their linear epitopes, and show their reactivity on 71 individuals from diverse human populations. Using single-residue mutagenesis we revealed the core functional residues for 232 of these epitopes. Finally, we show the diagnostic performance of identified antigens on challenging samples. These datasets enable the study of the Chagas antibody repertoire at an unprecedented depth and granularity, while also providing a rich source of serological biomarkers., (© 2023. The Author(s).) more...
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- 2023
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42. Tango-Therapy Intervention for Older Adults with Cognitive Impairment Living in Nursing Homes: Effects on Quality of Life, Physical Abilities and Gait.
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Bracco L, Cornaro C, Pinto-Carral A, Koch SC, and Mourey F
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- Humans, Aged, Gait, Nursing Homes, Walking, Quality of Life, Cognitive Dysfunction
- Abstract
Cognitive impairment in older adults is associated with poor gait performance, physical decline, falls and poor quality of life. This paper analyzes the feasibility and efficacy of tango-based intervention in older people living in nursing homes with and without cognitive impairment. A multicenter study, with pre- and post-test, was carried out. Intervention attendance, well-being, physical abilities (short physical performance battery), walking performance, functional capacities (Katz Index) and quality of life (quality of life in Alzheimer's disease) were assessed. Fifty-four participants (84.9 ± 6.7 years, mini mental state examination 14.5 ± 7.4) completed the protocol. Intervention attendance was 92%, and the mean subjective well-being after each session was 4.5 ± 0.5 (on a five-point scale). A statistically significant improvement was found in the quality of life ( p = 0.030). Non-statistically significant changes were found in walking performance ( p = 0.159), physical abilities ( p = 0.876) and in functional capacities ( p = 0.253). This study shows feasibility and suggests evidence for the effects of tango therapy on well-being and quality of life. Further studies are necessary to contrast these findings and to support the role of tango interventions as a holistic approach to prevent functional decline in older people with cognitive impairment. more...
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- 2023
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43. Advancing nursing in Italy through the development and evaluation of an innovative postgraduate programme in Family and Community Nursing - A pilot study.
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Musio ME, Vassalini L, Centanaro R, Bariola M, Ghiozzi M, Santacroce M, Bacigalupo L, Razeto G, Soldano G, Bracco L, Aleo G, Zanini M, Catania G, Manganello F, Pozzi F, Sasso L, and Bagnasco A
- Subjects
- Humans, Italy, Pilot Projects, Curriculum
- Abstract
Introduction: Due to the impact on the public health systems of the ageing and the increasing frailty of the population, the European Union and the World Health Organisation have emphasised how family and community nurses (FCNs) could play an important role in supporting the ageing process through prevention, promotion, and protection in the territory., Methods: This study describes the first experience in Italy of a one-year postgraduate blended-learning master course divided into 5 modules for FCNs piloted as part of the EuropeaN curriculum for fAmily aNd Community nursE (ENhANCE) 2018-2020 project, funded by the European Commission. The 5 modules focused on: Epidemiology and Prevention (14 ECTS); Fundamentals of care (19 ECTS); Organisational Models and Priority Health Problems (12 ECTS); Communication Models and Continuity of Care (5 ECTS); and Nursing Research (10 ECTS). Participants included a total of 45 students and 23 lecturers and a team of clinical tutors., Results: The Italian pilot course for the FCNs proved to be a successful example of innovative teaching methods using blended didactic methods, which enabled participants to achieve high-standard learning outcomes and competencies in the field of family and community nursing., Conclusions: The pilot course is well suited to preparing competent family and community nurses to meet the growing healthcare needs of the population. Therefore, we have planned to replicate this course to increase the workforce of family and community nurses, who through their healthcare services aimed at prevention, promotion and protection, will ensure high quality services to the public and consequently relieve the burden on acute hospitals., Competing Interests: Conflict of interest statement The authors declare that there are no existing or potential conflicts of interest of financial, personal or any other nature that could affect or bias the results of this study., (©2022 Pacini Editore SRL, Pisa, Italy.) more...
- Published
- 2022
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44. Dual Effect of PER2 C111G Polymorphism on Cognitive Functions across Progression from Subjective Cognitive Decline to Mild Cognitive Impairment.
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Mazzeo S, Bessi V, Bagnoli S, Giacomucci G, Balestrini J, Padiglioni S, Tomaiuolo G, Ingannato A, Ferrari C, Bracco L, Sorbi S, and Nacmias B
- Abstract
Background: Periodic circadian protein homolog 2 ( PER2 ) has a role in the intracellular signaling pathways of long-term potentiation and has implications for synaptic plasticity. We aimed to assess the association of PER2 C111G polymorphism with cognitive functions in subjective cognitive decline (SCD)., Methods: Forty-five SCD patients were included in this study. All participants underwent extensive neuropsychological investigation, analysis of apolipoprotein E ( APOE ) and PER2 genotypes, and neuropsychological follow-up every 12 or 24 months for a mean time of 9.87 ± 4.38 years., Results: Nine out of 45 patients (20%) were heterozygous carriers of the PER2 C111G polymorphism (G carriers), while 36 patients (80%) were not carriers of the G allele (G non-carriers). At baseline, G carriers had a higher language composite score compared to G non-carriers. During follow-up, 15 (34.88%) patients progressed to mild cognitive impairment (MCI). In this group, we found a significant interaction between PER2 G allele and follow-up time, as carriers of G allele showed greater worsening of executive function, visual-spatial ability, and language composite scores compared to G non-carriers., Conclusions: PER2 C111G polymorphism is associated with better language performance in SCD patients. Nevertheless, as patients progress to MCI, G allele carriers showed a greater worsening in cognitive performance compared to G non-carriers. The effect of PER2 C111G polymorphism depends on the global cognitive status of patients. more...
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- 2021
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45. Influence of ApoE Genotype and Clock T3111C Interaction with Cardiovascular Risk Factors on the Progression to Alzheimer's Disease in Subjective Cognitive Decline and Mild Cognitive Impairment Patients.
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Bessi V, Balestrini J, Bagnoli S, Mazzeo S, Giacomucci G, Padiglioni S, Piaceri I, Carraro M, Ferrari C, Bracco L, Sorbi S, and Nacmias B
- Abstract
Background: Some genes could interact with cardiovascular risk factors in the development of Alzheimer's disease. We aimed to evaluate the interaction between ApoE ε4 status, Clock T3111C and Per2 C111G polymorphisms with cardiovascular profile in Subjective Cognitive Decline (SCD) and Mild Cognitive Impairment (MCI)., Methods: We included 68 patients who underwent clinical evaluation; neuropsychological assessment; ApoE , Clock and Per2 genotyping at baseline; and neuropsychological follow-up every 12-24 months for a mean of 13 years. We considered subjects who developed AD and non-converters., Results: Clock T3111C was detected in 47% of cases, Per2 C111G in 19% of cases. ApoE ε4 carriers presented higher risk of heart disease; Clock C-carriers were more frequently smokers than non C-carriers. During the follow-up, 17 patients progressed to AD. Age at baseline, ApoE ε 4 and dyslipidemia increased the risk of conversion to AD. ApoE ε4 carriers with history of dyslipidemia showed higher risk to convert to AD compared to ApoE ε4- groups and ApoE ε4+ without dyslipidemia patients. Clock C-carriers with history of blood hypertension had a higher risk of conversion to AD., Conclusions: ApoE and Clock T3111C seem to interact with cardiovascular risk factors in SCD and MCI patients influencing the progression to AD. more...
- Published
- 2020
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46. A steroid-induced bilateral avascular necrosis of the femoral head in an underage patient affected by multiple sclerosis.
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Carulli C, Nistri L, Bracco L, Giannini M, and Amato MP
- Abstract
Patients affected by Multiple Sclerosis are often treated by pulsed intravenous corticosteroids to manage acute relapses with positive outcomes. The intravenous administration is frequently associated to avascular necrosis of several bones, particularly the femur. The present report regards a case of an underage MS patient with a bilateral ANFH secondary to pulsed administrations of steroids, managed by a conservative approach on a hip, and by a novel surgical technique on the contralateral side. more...
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- 2015
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47. Regional analysis of the magnetization transfer ratio of the brain in mild Alzheimer disease and amnestic mild cognitive impairment.
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Mascalchi M, Ginestroni A, Bessi V, Toschi N, Padiglioni S, Ciulli S, Tessa C, Giannelli M, Bracco L, and Diciotti S
- Subjects
- Aged, Aged, 80 and over, Alzheimer Disease complications, Amnesia complications, Cognitive Dysfunction complications, Female, Humans, Magnetic Fields, Male, Middle Aged, Reproducibility of Results, Sensitivity and Specificity, Alzheimer Disease pathology, Amnesia pathology, Amygdala pathology, Hippocampus pathology, Image Interpretation, Computer-Assisted methods, Magnetic Resonance Imaging methods
- Abstract
Background and Purpose: Manually drawn VOI-based analysis shows a decrease in magnetization transfer ratio in the hippocampus of patients with Alzheimer disease. We investigated with whole-brain voxelwise analysis the regional changes of the magnetization transfer ratio in patients with mild Alzheimer disease and patients with amnestic mild cognitive impairment., Materials and Methods: Twenty patients with mild Alzheimer disease, 27 patients with amnestic mild cognitive impairment, and 30 healthy elderly control subjects were examined with high-resolution T1WI and 3-mm-thick magnetization transfer images. Whole-brain voxelwise analysis of magnetization transfer ratio maps was performed by use of Statistical Parametric Mapping 8 software and was supplemented by the analysis of the magnetization transfer ratio in FreeSurfer parcellation-derived VOIs., Results: Voxelwise analysis showed 2 clusters of significantly decreased magnetization transfer ratio in the left hippocampus and amygdala and in the left posterior mesial temporal cortex (fusiform gyrus) of patients with Alzheimer disease as compared with control subjects but no difference between patients with amnestic mild cognitive impairment and either patients with Alzheimer disease or control subjects. VOI analysis showed that the magnetization transfer ratio in the hippocampus and amygdala was significantly lower (bilaterally) in patients with Alzheimer disease when compared with control subjects (ANOVA with Bonferroni correction, at P < .05). Mean magnetization transfer ratio values in the hippocampus and amygdala in patients with amnestic mild cognitive impairment were between those of healthy control subjects and those of patients with mild Alzheimer disease. Support vector machine-based classification demonstrated improved classification performance after inclusion of magnetization transfer ratio-related features, especially between patients with Alzheimer disease versus healthy subjects., Conclusions: Bilateral but asymmetric decrease of magnetization transfer ratio reflecting microstructural changes of the residual GM is present not only in the hippocampus but also in the amygdala in patients with mild Alzheimer disease. more...
- Published
- 2013
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48. Effect of cholinesterase inhibitors on attention.
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Pepeu G, Giovannini MG, and Bracco L
- Subjects
- Acetylcholine physiology, Alzheimer Disease physiopathology, Arousal drug effects, Arousal physiology, Attention physiology, Attention Deficit Disorder with Hyperactivity drug therapy, Attention Deficit Disorder with Hyperactivity physiopathology, Attention Deficit Disorder with Hyperactivity psychology, Brain drug effects, Brain physiopathology, Humans, Nootropic Agents therapeutic use, Tacrine therapeutic use, Alzheimer Disease drug therapy, Alzheimer Disease psychology, Attention drug effects, Cholinesterase Inhibitors therapeutic use
- Abstract
Advantages and limits of the use of cholinesterase inhibitors (ChEI) in Alzheimer's disease (AD) are well established. Their effects result from an increase in extracellular acetylcholine (ACh) whose hydrolysis is prevented by cholinesterase inhibition. In this way, the cholinergic deficit which characterizes AD may be corrected. This overview discusses which components of the cognitive process are improved by ChEI administration. In animal experiments, the increase in ACh release, detected in brain areas during behavioral tasks designed to tax attentional processes, demonstrates that an activation of cholinergic neurons underlies arousal and attention. Since arousal and attention depend on activation of the forebrain cholinergic system, it is to be expected that the loss of cholinergic neurons occurring in AD may lead to impairment of the attentional processes. Indeed, a consensus exists that attention is the first non-memory domain to be affected in AD, before deficits in language and visuo-spatial functions. The difficulties with daily living, which occur even in mild AD, may be related to attentional deficits. ChEIs, by restoring the cholinergic activity, should improve attention. If the cognitive changes resulting from ChEI treatment in AD patients are assessed with appropriate tests or selected items of the scales, a predominant effect on attention and executive functions emerges. In a group of 121 subjects with mild to moderate AD, (MMSE score 21.88 ± 3.63) followed in the Alzheimer Unit in Florence, after a year of treatment with standard doses of ChEIs, it was observed a stabilization of the disease, characterized by no changes of the tests evaluating attention and executive functions but a worsening of those involving memory mechanisms. These findings suggest that ChEI treatment preserves attention more than memory. Finally, the electrophysiological and neurochemical mechanisms through which the activation of the cholinergic forebrain neurons enhance attention and create the condition for information acquisition are reviewed., (Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.) more...
- Published
- 2013
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49. Progranulin genetic screening in frontotemporal lobar degeneration patients from central Italy.
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Bagnoli S, Piaceri I, Tedde A, Piacentini S, Nannucci S, Bracco L, Sorbi S, and Nacmias B
- Subjects
- Adult, Aged, Case-Control Studies, Female, Frontotemporal Lobar Degeneration epidemiology, Gene Frequency, Genetic Predisposition to Disease, Humans, Intercellular Signaling Peptides and Proteins metabolism, Italy epidemiology, Male, Middle Aged, Polymorphism, Genetic physiology, Progranulins, Frontotemporal Lobar Degeneration diagnosis, Frontotemporal Lobar Degeneration genetics, Genetic Testing, Intercellular Signaling Peptides and Proteins genetics
- Abstract
Recently, mutations in the progranulin gene (GRN) were reported to account for the vast majority of Frontotemporal lobar Degeneration (FTLD) and a growing number of reports describe the implication of this gene in the development of the FTLD pathology with a significant variation in clinical features. To better clarify the contribution of GRN mutations to Italian FTLD, we screened 381 subjects: 171 cases and 210 healthy subjects, all from Central Italy, particularly of Tuscan origins. GRN gene was analyzed using High Resolution Melting Analysis and automated Genetic Analyzer. Human Progranulin ELISA Kit was employed to determine the plasma progranulin levels. The screening showed a total of six genetic variants in the GRN gene: 3 pathogenic and 3 non pathogenic in 13 out of 171 patients. The rare intronic variant IVS2 +7 G > A was found in one patient. The pathogenetic mutation, p.T272SfsX10, is confirmed as the most common GRN mutation in Italian FTLD patients with a frequency in our study of 2.32%. Moreover, we identified the first Italian patient with the p.R493X mutation, to date described in 43 families worldwide. Our data report, for the first time, the occurrence of GRN mutations in Tuscany, Central Italy, confirming that genetic variations in this gene could be a considerable genetic cause of FTLD and that genetic screening might be useful both in familial and sporadic FTLD patients. more...
- Published
- 2012
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50. High resolution analysis of the human transcriptome: detection of extensive alternative splicing independent of transcriptional activity.
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Zhou W, Calciano MA, Jordan H, Brenner M, Johnson S, Wu D, Lei L, Pallares D, Beurdeley P, Rouet F, Gill PS, Bracco L, Soucaille C, and Einstein R
- Subjects
- Genomics, Humans, Sequence Analysis, DNA, Transcription, Genetic, Alternative Splicing, Gene Expression Profiling methods, Genome, Human, Oligonucleotide Array Sequence Analysis methods
- Abstract
Background: Commercially available microarrays have been used in many settings to generate expression profiles for a variety of applications, including target selection for disease detection, classification, profiling for pharmacogenomic response to therapeutics, and potential disease staging. However, many commercially available microarray platforms fail to capture transcript diversity produced by alternative splicing, a major mechanism for driving proteomic diversity through transcript heterogeneity., Results: The human Genome-Wide SpliceArray(TM) (GWSA), a novel microarray platform, utilizes an existing probe design concept to monitor such transcript diversity on a genome scale. The human GWSA allows the detection of alternatively spliced events within the human genome through the use of exon body and exon junction probes to provide a direct measure of each transcript, through simple calculations derived from expression data. This report focuses on the performance and validation of the array when measured against standards recently published by the Microarray Quality Control (MAQC) Project. The array was shown to be highly quantitative, and displayed greater than 85% correlation with the HG-U133 Plus 2.0 array at the gene level while providing more extensive coverage of each gene. Almost 60% of splice events among genes demonstrating differential expression of greater than 3 fold also contained extensive splicing alterations. Importantly, almost 10% of splice events within the gene set displaying constant overall expression values had evidence of transcript diversity. Two examples illustrate the types of events identified: LIM domain 7 showed no differential expression at the gene level, but demonstrated deregulation of an exon skip event, while erythrocyte membrane protein band 4.1 -like 3 was differentially expressed and also displayed deregulation of a skipped exon isoform., Conclusion: Significant changes were detected independent of transcriptional activity, indicating that the controls for transcript generation and transcription are distinct, and require novel tools in order to detect changes in specific transcript quantity. Our results demonstrate that the SpliceArray(TM) design will provide researchers with a robust platform to detect and quantify specific changes not only in overall gene expression, but also at the individual transcript level. more...
- Published
- 2009
- Full Text
- View/download PDF
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