Author: "Bratu, A" / Search Limiters: Available in Library Collection - Searchworks@Jio Institute Digital Library Search Results

3,178 results on '"Bratu, A"'

1. The role of ER exit sites in maintaining P-body organization and integrity during Drosophila melanogaster oogenesis

Author: Milano, Samantha N, Bayer, Livia V, Ko, Julie J, Casella, Caroline E, and Bratu, Diana P
Published: 2024
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2. Impact of NEWTON Technology-Enhanced Learning Solutions on Knowledge Acquisition in Pilots Involving Students with Hearing Impairments

Author: Marilena Bratu, Cristina Hava Muntean, Cristian Buica-Belciu, Sabina Stan, and Gabriel-Miro Muntean
Abstract: Contributions: This article presents the results of a study carried out as part of two large-scale pilots and analyzes the impact of the use of modern technologies in education in term of knowledge acquisition in case of students with hearing disabilities. Background: Teaching topics from STEM area is a challenging task for all teachers who have students with hearing disabilities in their class. On the one hand, because of the high degree of difficulty of the information in this field and on the other hand, because of the difficulties that students with hearing disabilities face in understanding this information. In this context, the use of modern technologies in education, but especially the way they are used together with traditional ones, can provide great support for teachers of students with special needs. Intended Outcomes: A set of modern technologies, i.e., virtual lab, virtual reality (VR), in the game-based learning context of the EU-funded NEWTON project, were employed in education as part of the Earth Course. The goal was to increase the accessibility of STEM information in the area of natural sciences for the benefit of students, especially those with hearing disabilities. Application Design: The study targeted secondary school students with hearing disabilities. Content related to natural sciences (i.e., wildlife and sealife) was presented as part of the Earth Course via innovative applications that included virtual laboratories and VR. Avatars were used to support the students with special needs (sign-language translation). Findings: The results of this study demonstrate that the use of modern technologies, combined with game-based learning in science lessons for students with hearing disabilities, contribute to increasing their knowledge level. The best results were obtained when these technologies were used in mixed lessons, alongside the traditional teaching methods.
Published: 2024
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3. Rural versus urban healthcare through the lens of health behaviors and access to primary care: a post-hoc analysis of the Romanian health evaluation survey

Author: Brîndușe, Lăcrămioara Aurelia, Eclemea, Irina, Neculau, Andrea Elena, Păunescu, Bogdan Alexandru, Bratu, Eugenia Claudia, and Cucu, Maria Alexandra
Published: 2024
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4. Rural versus urban healthcare through the lens of health behaviors and access to primary care: a post-hoc analysis of the Romanian health evaluation survey

Author: Lăcrămioara Aurelia Brîndușe, Irina Eclemea, Andrea Elena Neculau, Bogdan Alexandru Păunescu, Eugenia Claudia Bratu, and Maria Alexandra Cucu
Subjects: Rural health, Primary health care, Health disparities, Health evaluation, Public aspects of medicine, RA1-1270
Abstract: Abstract Background Worldwide, rural populations are recognized to be exposed to increased health challenges due to their living and working environment, socioeconomic status, and access to health services. According to the Romanian Country Health Profile 2023, approximately 46% of all deaths recorded in Romania in 2019 could be attributed to behavioral risk factors such as tobacco smoking, dietary risks, alcohol consumption and low physical activity. No data on rural versus urban areas are available to date, and research is needed to document health inequalities, identify barriers to health services, and explore solutions. Methods This study is an analysis of data collected during the Health Evaluation Survey carried out by the National Institute of Public Health in 2022 and aimed to reveal differences in health risk factors between rural and urban areas. The analysis was carried out under the methodological framework of the Health Evaluation Survey 2022, which is coordinated by the National Institute of Public Health. Results Our study’s objectively measured data revealed that the overall health profile of rural communities is characterized by lower education levels, lower incomes, and higher binge drinking rates than those of their urban counterparts. Additionally, rural inhabitants more often have high blood pressure, are more overweight and obese (per body mass index measurements) and have higher fasting plasma glucose. The health profile of the urban population revealed higher education levels and greater proportions of people with adequate monthly income, people with daily alcohol consumption, people who smoke, and people with hypercholesterolemia. Access to primary health care evaluated through proxy indicators was lower in rural areas but was relatively good overall. Conclusions Our analysis of the health profile of rural communities revealed a greater prevalence of obesity and overweight, especially among women, and an increased prevalence of heavy drinking among men. Access to primary health care evaluated through proxy indicators is lower in rural areas but is relatively good overall. Lower education levels and the possibility of lower health literacy underpin the need for targeted health education campaigns. Sustainable strategies for rural health need to be identified, especially in the field of health promotion and disease prevention programs. Trial registration This study is observational research involving human participants where no interventions were applied to the study population.
Published: 2024
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5. The New European Bauhaus: Beautiful-Sustainable-Together in STARHAUS

Author: Petruț Bratu, Akhilesh Kumar Srivastava, Alex Butean, and Letizia Vaccarella
Subjects: new european bauhaus, starhaus, interdisciplinarity, sustainability, technology, social cohesion., Political institutions and public administration (General), JF20-2112
Abstract: The article ‘The New European Bauhaus: Beautiful-Sustainable-Together in STARHAUS’ aims to explore the principles of the New European Bauhaus (NEB) policy and analyze how these principles are implemented across various European projects, with a specific focus on the STARHAUS project. The New European Bauhaus is an interdisciplinary initiative launched by the European Commission to foster a sustainable and inclusive future by combining aesthetics, sustainability, and inclusiveness. It seeks to create spaces, products, and services that are environmentally friendly, inclusive, and accessible while enhancing quality of life.
Published: 2024
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6. Postoperative pain management in the enhanced recovery after surgery (ERAS) for emergency laparoscopic cholecystectomy

Author: Antonio Mihai Istrate, Dragos Serban, Dan Dumitrescu, Corneliu Tudor, Laurentiu Simion, Vlad Denis Constantin, Ciprian Tanasescu, Dan Giorgian Bratu, Bogdan Mihai Cristea, Catalin Cicerone Grigorescu, and Ana Maria Dascalu
Subjects: laparoscopic cholecystectomy, emergency, enhanced recovery after surgery (eras), pain management, Medicine (General), R5-920
Abstract: Introduction. Enhanced recovery after surgery (ERAS) is a new patient-centered concept that aims to deliver high-quality perioperative care to surgical patients. This study was performed to compare the effectiveness of the pain management measures in an ERAS-protocol versus the traditional approach of postoperative pain. Materials and Methods. A comparative prospective study was performed on 50 patients admitted in the Fourth General Surgery of University Emergency Hospital of Bucharest between 2022 and 2024, with the diagnosis of acute cholecystitis, undergoing emergency laparoscopic cholecystectomy. The patients were randomly assigned into two study groups, an ERAS-group and a Traditional group, according to the type of perioperative care applied. The evaluated outcomes were length-of-stay; preoperative anxiety level, leukocyte count at admission and 24 hours postoperatively, postoperative pain levels quantified using Visual Analog Scale 24 hours after surgery and postoperative nausea and vomiting events. Results. The two study subgroups were comparable in terms of demographic and clinical preoperative characteristics. Statistical analysis showed significant lower values of preoperative anxiety level in ERAS group (p
Published: 2024
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7. COMPARATIVE ANALYSIS OF INTERMAXILLARY REGISTRATION: ANTERIOR JIG METHOD VS. CLASSIC APPROACH IN ANTERIOR REHABILITATION WITH LATERAL OCCLUSAL CONTACT PRESERVATION

Author: Sorin Gheorghe Mihali, Stefania Dinu, Dan Lolos, Roxana Oancea, Anca Tudor, Nicola Timon Burnaz, Remus Christian Bratu, and Dana Cristina Bratu
Subjects: anterior jig, intermaxillary relations, centric relation, Dentistry, RK1-715
Abstract: This study compares the anterior jig method with the classic bimanual technique for recording intermaxillary relations in patients who have lost anterior occlusal stops. A total of 51 patients (36 females, 16 males, mean age 42.6 years) had their anterior teeth prepared from canine to canine, resulting in the loss of anterior occlusal stops. Occlusal and incisal records were obtained using 3Shape (Denmark) digital scanning technology and analyzed with Exocad (Exocad GmbH, Germany) software. The results showed that the anterior jig method significantly reduced discrepancies, with an average difference of 0.837 mm, compared to the classic method. This difference was statistically significant (Mann-Whitney, p
Published: 2024
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8. CLINICAL EVALUATION OF POST-ORTHODONTIC STABILIZATION IN ANTERIOR TEETH USING AN ESTHETIC FULL-CONTOUR LITHIUM DISILICATE RETAINER AND LAYERED LITHIUM DISILICATE RESTORATIONS

Author: Adrian Jantea, Dana Cristina Bratu, Dan Lolos, Anca Tudor, Remus Christian Bratu, and Sorin Gheorghe Mihali
Subjects: lithium disilicate, orthodontic retention, cosmetic dentistry, anterior teeth, Dentistry, RK1-715
Abstract: This study evaluates the use of full-contour lithium disilicate retainers and layered lithium disilicate restorations for the stabilization of mandibular anterior teeth following orthodontic treatment. Lithium disilicate ceramics were selected for their superior strength, biocompatibility, and aesthetic qualities, providing a solution that minimizes discomfort and sensitivity for patients. The clinical performance of these retainers was monitored across 18 cases. Out of the 18 retainers, 10 experienced fractures. Despite the fractures, patients expressed satisfaction with the aesthetic and functional benefits of the lithium disilicate retainers, especially in comparison to traditional metal alternatives. These findings underscore the need for careful material selection and patient education, as lithium disilicate retainers offer a reliable and aesthetically appealing option for post-orthodontic stabilization, though they may require regular follow-up and monitoring due to their susceptibility to fractures.
Published: 2024
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9. CHARACTERIZATION AND BIOSAFETY PROFILE OF EUGENOL INCORPORATED IN IRON OXIDE NANOPARTICLES

Author: Alexandra-Ioana Dănilă, Stefania Dinu, Daniel Pop, Malina Popa, Ramona Amina Popovici, Mihai Rominu, Mhd Kher Alsaeyd Ahmad, Dana Emanuela Pitic(Coț), and Dana Cristina Bratu
Subjects: hematite, physicochemical characterization, in vitro assessment, viability, cytotoxicity, Dentistry, RK1-715
Abstract: Aim of the study Eugenol, a phenolic compound commonly found in plants like clove and bay leaves, has garnered significant attention in the field of dentistry due to its diverse pharmacological properties. In dentistry, eugenol is frequently employed in various forms, such as in polymerized cement with zinc oxide for restorative purposes. Its applications extend to endodontic cements like zinc oxide-eugenol formulations, which are commonly used in dental procedures. So far, according to our knowledge, no study in the literature has approached formulations based on iron oxide nanoparticles and eugenol, this study being the first. Materials and methods In the present study, it was developed for the first time a formulation based on iron oxide nanoparticles obtained through the combustion method, embedded on its surface with eugenol. The prepared formulation was characterized through electron microscopy investigations, followed by further in vitro evaluation as concerned with their biosafety use on a healthy murine epidermal cell line. Results The results obtained showed that the naked iron oxide nanoparticles are biocompatible and safe to use on the healthy murine epidermal cell line, while the eugenol compound exhibits a dose-dependent cytotoxicity reaching until a value of ~17% at the highest tested dose (100 μg/mL). In addition, the cytotoxicity of eugenol decreased when this was embedded on the iron oxide nanoparticles surface, recording a value of 11% at the highest concentration tested. Conclusions In conclusion, the in vitro studies on such type of formulation in dentistry and dental medicine highlight their multifaceted applications of iron oxide nanoparticles as well as eugenol, emphasizing their potential for advancing dental treatments and diagnostics.
Published: 2024
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10. THE IMPACT OF MASSETER MUSCLE DYSFUNCTION ON ORAL REHABILITATION: CHALLENGES AND TREATMENT STRATEGIES

Author: Gabi Topor, Ana Magdalena Bratu, Iulian Catalin Bratu, Olimpia Dumitriu-Buzia, Patru Radu Stanciu, Dragos Stanciu, Nicolae Sarbu, Mariana Ilie, Silvia Nica, Norina Consuela Forna, Raluca Uleanu, and Iulia Alecsandra Salcianu
Subjects: masseter muscle dysfunction, bruxism, medication, surgical options, oral rehabilitation, Dentistry, RK1-715
Abstract: Dysfunctions of the masseter muscles represent a significant challenge in the field of oral rehabilitation, negatively influencing the success of prosthetic, orthodontic, and surgical treatments. This review explores the impact of these dysfunctions on various aspects of oral rehabilitation, identifying the main challenges and providing effective treatment strategies. Initially, the anatomy and function of masseter muscles are discussed, followed by an analysis of common types of dysfunction and their causes. The review then details the complications encountered in the oral rehabilitation process due to masseter dysfunctions, highlighting difficulties in diagnosis and planning. Various treatment strategies are presented, including conservative methods, drug interventions, and surgical options, emphasizing the importance of an interdisciplinary approach. By including case studies, the practical applications and outcomes of proposed treatments are illustrated. In conclusion, the article emphasizes the need for early diagnosis and adequate treatment to ensure the long-term success of oral rehabilitation in the presence of dysfunctions of the masseter muscles.
Published: 2024
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11. BIRTH CONTROL PILLS AND POSSIBLE INFLUENCES ON THE FETUS

Author: Alina Mihaela Calin, Gabi Topor, Nicolae Sarbu, Iulia Alecsandra Salcianu, Ana Magdalena Bratu, Minodora Campanu (Banu), Simona Parvu, Norin Forna, and Iulian Catalin Bratu
Subjects: birth control pills, pregnancy, adverse effects, mechanism of action, risks and complications, Dentistry, RK1-715
Abstract: Birth control pills are widely used around the world for birth control and prevention of unwanted pregnancy. However, there are concerns about their safety during pregnancy and possible effects on the fetus. This article aims to examine in depth the current evidence on the impact of birth control on the foetus. By analysing the mechanism of action of birth control pills, relevant clinical trials and associated potential complications, the risks and safety of contraceptive use during pregnancy are explored. The different types of contraceptives and the specific risks associated with each are discussed, providing recommendations for women who use birth control and become or become pregnant. Through this literature review, the aim is to provide a clearer understanding of this topic and to provide practical guidance for healthcare professionals and women in this situation. Further investigation into the mechanisms of action of birth control pills during pregnancy and how they may influence fetal development could provide useful information for managing and counseling women who are pregnant or planning to become pregnant.
Published: 2024
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12. THE ROLE OF SALIVARY GLANDS IN ORAL REHABILITATION: FUNCTIONS, IMPORTANCE, PATHOLOGY AND THERAPEUTIC APPROACHES

Author: Kamel Earar, Alina-Ramona Dimofte, Roxana Dragan, Iulia Alecsandra Salcianu, Irina Ruxandra Strambu, Iulian Catalin Bratu, Nicolae Sarbu, Mariana Ilie, Ana Magdalena Bratu, Doriana Agop Forna, and Gabi Topor
Subjects: salivary glands, salivary gland pathology, therapeutic approaches, oral rehabilitation, Dentistry, RK1-715
Abstract: The salivary glands are essential for oral health, providing not only environments for digestion and taste, but also protection from pathogens. This review examines the functions of salivation, the importance of salivary glands in the context of oral pathology, and therapeutic approaches for their dysfunctions. Pathologies of the salivary glands range from minor conditions, such as sialadenitis, to severe conditions, such as cancer of the salivary glands. These conditions can affect quality of life, the ability to eat and speak, and have systemic implications. Treatment of salivary gland dysfunctions includes pharmacological therapies to stimulate salivary secretion, the use of saliva substitutes, and physical therapies such as ultrasound therapy. Management is aimed at relieving symptoms and improving the function of affected glands. Antioxidant supplements, depending on your circadian rhythm, may help reduce oxidative stress associated with glandular pathologies.
Published: 2024
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13. Training of primary teachers in the integration of faith in the Romanian language class

Author: Didina Bratu, Raquel Bouvet de Korniejczuk, and Marcos Enrique Flores González
Subjects: Integral education, levels of integration, teaching strategies, role of the teacher, Romanian language learning, Education (General), L7-991, Theory and practice of education, LB5-3640
Abstract: This qualitative action research study, employing a case study approach, explores the integration of faith into teaching practices within Romanian Adventist schools, aiming to enhance both intellectual and creative student development through a biblical lens. Utilizing Interpretativist and Socio-Constructivist paradigms, the research combines multiple qualitative methods—observations, semi-structured interviews, focus groups, and experiential journals—to examine how faith integration impacts students’ critical thinking and the learning environment. The findings underscore the significance of deliberate planning and teacher roles as facilitators and role models in embedding faith throughout all phases of education (pre-training, during training, and post-training). The study highlights the important role of teacher commitment to ongoing improvement and provides insights into effective strategies for integrating faith into teaching practices, ultimately contributing to a more holistic and enriching educational experience.
Published: 2024

14. Using metacognitive strategies to improve reading comprehension in middle school students

Author: Anca Mariana Dragostin Bratu and Víctor Andrés Korniejczuk
Subjects: Reading comprehension, metacognition, metacognitive strategies, Education (General), L7-991, Theory and practice of education, LB5-3640
Abstract: Despite the easy accessibility of information and its widespread availability, there is a growing concern about the rise of functional illiteracy in various regions across the globe. This issue extends beyond just the realm of education and impacts the society at large, as individuals who struggle to grasp information and lack the skills to effectively choose and process it face direct consequences on their current well-being and future opportunities. To enhance reading comprehension levels among both children and adults, a multitude of research studies have been carried out. These investigations have highlighted that the implementation of metacognitive strategies, which are recognized and utilized by students and educators alike, has the potential to enhance reading comprehension abilities in individuals, whether they are dealing with their native language or a foreign one, irrespective of their age. The findings suggest that by incorporating such strategies into teaching practices and learning approaches, significant improvements can be made in the overall literacy levels of populations, thereby addressing the issue of functional illiteracy in a comprehensive manner. In this paper, we develop a comprehensive theoretical framework to analyze the factors influencing reading comprehension, as well as the relationship with metacognitive strategies.
Published: 2024

15. INTRACRANIAL ANEURYSMS IN CHILDREN - A NEW PERSPECTIVE

Author: Alexandru Vlad Ciurea, H. Ples, Nicolaie Dobrin, Andrei Adrian Popa, Bogdan-Gabriel Bratu, and Antonio-Daniel Corlatescu
Subjects: intracranial aneurysms, children, microsurgical approach, early therapy, DSA-angiography, extended Glasgow, Neurology. Diseases of the nervous system, RC346-429
Abstract: Introduction Intracranial aneurysms in children are very rare pathologic entities. (1200 cases presented in literature from 1939-2011). Material and Methods The authors present 51 cases of children (aged: 0-16) operated between January 1999 and December 2023 - 24 years in three neurosurgical centers: “Bagdasar Arseni” Emergency University Hospital (Bucharest), Sanador Clinical Hospital (Bucharest) and Timis County Emergency Hospital (Timisoara). We collected data from many children’s intracranial aneurysms cases because “Bagdasar-Arseni” Emergency University Hospital has the most important pediatric neurosurgical unit in the country. Regarding our series, pediatric aneurysms represent 6.14% (51 cases) of all operated intracranial aneurysms (765 cases). The mean age of the patients was 14.3 years. There were 29 boys (58.7%) and 22 girls (41.2%). The clinical features are dominated by headache (48 cases - 95.7%), neck stiffness (45 cases - 91.4%), vomiting (44 cases - 89.3%), focal neurological deficit (24 cases - 44.6%), an altered level of consciousness (17 cases - 36.1%), seizures (24 cases - 44.6%, fever (20 cases - 34%). The majority of patients were Hunt & Hess Il at admittance (27 cases, 53%). All neuroimagistic investigations were done in the first 48 hours (CT, DSA, MRI). Locations: anterior communicating artery aneurysms (20 cases, 36.1%), followed by middle cerebral artery aneurysms (15 cases, 25.5%) and internal carotid artery bifurcation aneurysms (9 cases, 19.1%) and so on. Many aneurysms were large and giant (18 cases - 31.9%). Microsurgery approach was performed in 48 cases (99.7%) and 3 case (4.4%) were endovascular approached. This represents a new vision because the actual endovascular way is extremely efficient and performant in occluding pediatric intracranial aneurysms. The Glasgow Outcome Scale (GOS) at six months postop. showed GR in 40 cases (78.5%), MD in 9 cases (17.2%), SD in 1 patient (2.1%) and (preoperative) death in 1 patient (2.1%). Conclusions Intracranial aneurysms in children are a very rare pathologic entity. Early microsurgical or endovascular approach is mandatory and has excellent results (good recovery).
Published: 2024
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16. POSSIBILITIES OF GYNECOLOGICAL DRUG TREATMENTS IN VAGINAL AND VULVAR CANDIDIASIS CAUSED BY DIABETES ASSOCIATED WITH ORAL PATHOLOGY

Author: Alina Mihaela Calin, Aurel Nechita, Ana Magdalena Bratu, Ciprian Adrian Dinu, Iulia Alecsandra Salcianu, Gabi Topor, Victorita Stefanescu, Cristian Guțu, Elena Roxana Bogdan Goroftei, Simona Parvu, Mioara Decuseară, and Iulian Catalin Bratu
Subjects: vaginal candidiasis, diabetes mellitus, vulvar candidiasis, drug treatment, Dentistry, RK1-715
Abstract: This review aims to evaluate efficacy and drug treatment options in cases of vaginal and vulvar candidiasis associated with diabetes. We conducted an exhaustive literature review, looking at relevant clinical trials, meta-analyses, and clinical experiences. Patients with candidiasis and diabetes mellitus were included in a clinical case study to assess their response to treatment. Antifungals such as fluconazole and clotrimazole have been effective in treating candidiasis, but success has been influenced by glucose control levels. Proper diabetes management, along with antifungal therapy, resulted in decreased recurrences. Treatment of candidiasis in a diabetic context requires an integrated approach, including antifungal therapy and adequate management of diabetes. Strict blood glucose control plays a crucial role in preventing recurrences and improving the quality of life of affected patients. Further studies are needed to better understand the complex interactions between diabetes and candidiasis, paving the way for the development of more personalized and effective treatment strategies.
Published: 2024
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17. ORAL REHABILITATION OF PREGNANT PATIENTS IN THE 7TH MONTH WITH CARDIO-VASCULAR PATHOLOGICAL IMPLICATIONS

Author: Kamel Earar, Aurel Nechita, Alina Mihaela Calin, Ana Magdalena Bratu, Ciprian Adrian Dinu, Alina-Ramona Dimofte, Sonia Teodora Statescu Manaila, Gabriela Stan, Gabi Topor, Victorita Stefanescu, Iulian Catalin Bratu, Doriana Agop-Forna, and Iulia Alecsandra Salcianu
Subjects: oral rehabilitation, pregnant patient, cardio-vascular pathology, prevention, Dentistry, RK1-715
Abstract: During pregnancy, dental care is important for the overall health of the mother and unborn baby. However, it is essential to take into account certain aspects when planning dental treatments in a pregnant woman with cardio-vascular pathological implications. It is important to coordinate with your medical and dental team to ensure a safe and effective treatment plan. Pregnancy can bring additional challenges for patients with cardiovascular pathological implications during dental treatments. The medical team must know these aspects to ensure safe and effective dental treatment. Pregnancy itself can affect the cardiovascular system, and this aspect should be taken into account during dental treatments in pregnant women. It is also important to pay attention to medications and procedures used in dentistry to minimize the risk of cardiovascular complications during this delicate period. The dental management of a pregnant patient in the third trimester of pregnancy in the 7th month should be approached with caution and special attention to ensure the safety of both lives. In general, dental treatments are recommended during pregnancy to prevent dental complications that can affect the general health of the mother and fetus
Published: 2024
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18. SURGICAL OR MEDICAL MANAGEMENT OF PERIODONTAL COMPLICATIONS OCCURRING DURING PREGNANCY

Author: Alina Mihaela Calin, Aurel Nechita, Kamel Earar, Gabriela Stan, Ana Magdalena Bratu, Ciprian Adrian Dinu, Norina Consuela Forna, Gabi Topor, Victorita Stefanescu, Mariana Ilie, Anca Bejan, Olimpia Dumitriu-Buzia, Iulia Alecsandra Salcianu, Doriana Agop-Forna, and Iulian Catalin Bratu
Subjects: periodontal complications, pregnancy, surgical management, drug management, oral health, Dentistry, RK1-715
Abstract: The study presents an assessment of surgical and drug management of periodontal complications during pregnancy, with a focus on the impact of these interventions on pregnant women’s oral health and fetal development. Management dedicated to periodontal complications during pregnancy can help improve the oral health of pregnant women and reduce the risk of associated obstetric complications. These findings support the need to integrate periodontal treatment into prenatal care to improve both maternal and fetal health. Women with pre-existing periodontal disease may experience a worsening of their condition during pregnancy, with potential repercussions on overall health. Understanding the hormonal effects and risks associated with periodontal complications during pregnancy is essential to implement appropriate management strategies and ensure proper oral care during this delicate period. Preventive management and prompt treatment can significantly contribute to maintaining periodontal health and reducing risks to the mother and fetus. Vitamin complexes, especially vitamin C, are essential for the functioning of the immune system and contribute to the synthesis of collagen, a protein important for tissue health, including gums. Adequate levels of vitamin C can help heal gum tissues and reduce inflammation.
Published: 2024
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19. Unpacking the Underpinnings of Collaborative Consumption in Central Asia: Perspectives from Kyrgyzstan

Author: Rodica Ianole-Călin, Elena Druică, Aichurok Ybyraimova, and Anca Bratu
Subjects: collaborative consumption, theory of planned behaviour, attitudes, perceived behavioural control, subjective norms, behavioural intention, kyrgyzstan, Political science, Social Sciences
Abstract: We investigate the motivators behind collaborative consumption in Kyrgyzstan by applying the theory of planned behaviour. Through examining 308 responses gathered from an online survey, we assess the connections between the intention to engage in collaborative consumption and influential factors. Our results reveal that attitude, perceived behavioural control, and subjective norms are the most influential predictors, with their impact ranked in descending order. Consequently, we delve into the theoretical and practical implications of these emerging collaborative practices and business models in Kyrgyzstan.
Published: 2024
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20. OCULAR REFRACTIVE STATUS IN CHILDREN AND ADOLESCENTS WITH TYPE 1 DIABETES

Author: Carmen Tiutiuca, Iulian Cătălin Bratu, Octavian Cătălin Ciobotaru, Nicolae Sârbu, Norin Forna, and Dinu Bogdan Tiutiuca
Subjects: Dentistry, RK1-715
Published: 2024
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21. ENDODONTIC ANATOMY OF SECOND MAXILLARY PREMOLARS AND THEIR RELATION TO MAXILLARY SINUS AS INDICATED BY CONE-BEAM COMPUTED TOMOGRAPHY

Author: Cristina Coralia Nistor, Elena Claudia Coculescu, Anca Oana Dragomirescu, Ioana Suciu, Ecaterina Ionescu, Luiza Maria Nicolcea, and Dana-Cristina Bratu
Subjects: maxillary premolars, endodontic anatomy, cbct, maxillary sinus, Dentistry, RK1-715
Abstract: The aim of this study was to evaluate the root and root canal morphology of maxillary second premolars and their relation to the maxillary sinus in a Romanian population using cone-beam computed tomographic (CBCT) imaging. A total of 280 cone-beam computed tomographic images of maxillary second premolars were obtained from 263 patients who required a preoperative assessment for treatment plan. The number of roots and root canals and root canal configuration were investigated and categorized using Vertucci’s criteria and the relationship between the root apices of maxillary second premolars and the floor of the maxillary sinus was studied. The majority of maxillary second premolars were single rooted. The most common configuration was type I, followed by type II Vertucci, for the premolars with 2 canals. The roots of the maxillary second premolars were predominantly outside the maxillary sinus. Maxillary second premolars in this study had a wide range of root and root canal internal anatomy variations.
Published: 2024
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22. ORAL THRUSH IN PREGNANT WOMEN: CAUSES, RISKS AND PREVENTION STRATEGIES

Author: Alina Mihaela Calin, Nicolae Sarbu, Gabi Topor, Iulian Catalin Bratu, Victorita Stefanescu, Simona Parvu, Silvia Nica, Denisa Batir Marin, Doriana Agop Forna, and Iulia Alecsandra Salcianu
Subjects: mouth sores, pregnancy, risks, hormonal changes, immune system, oral hygiene, Dentistry, RK1-715
Abstract: Canker sores are a common condition among pregnant women, having a significant impact on oral and overall health. This article explores the causes, risks, and prevention strategies associated with mouth sores during pregnancy. Hormonal changes, weakening of the immune system, and stress are relevant factors in their occurrence. Risks include physical and emotional discomfort, as well as possible pregnancy complications. Proper oral hygiene, balanced nutrition, and stress reduction are essential strategies for preventing oral thrush. Treatment during pregnancy requires a gentle approach, and treatment options must be safe for the mother and baby. In conclusion, proper management of mouth sores during pregnancy is essential for the oral and general health of pregnant women and the fetus. The use of transdermal systems for administering crucial oils to pregnant women is an innovative and effective method of treatment of canker sores in pregnant women, offering multiple benefits and ensuring increased safety for mother and baby.
Published: 2024
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23. IMPACT OF ORAL REHABILITATION ON THE QUALITY OF LIFE OF PATIENTS WITH PSYCHIATRIC CONDITIONS AND MEDICATION MANAGEMENT

Author: Kamel Earar, Gabi Topor, Norina Consuela Forna, Patru Radu Stanciu, Roxana Dragan, Alina-Ramona Dimofte, Marius Vacaru Carnaru, Iulian Catalin Bratu, Ionuta Grigore, and Iulia Alecsandra Salcianu
Subjects: oral rehabilitation, prevention, psychiatry, medication management, Dentistry, RK1-715
Abstract: Psychiatric conditions significantly affect patients’ quality of life, and associated dental problems can aggravate this situation. Through treatments such as dentures, dental implants, and periodontal therapies, oral rehabilitation plays a crucial role in relieving oral discomfort and improving masticatory function and aesthetics. This leads to increased self-confidence and reduced social stigma, which are essential for mental well-being. Also, improved oral health facilitates adherence to psychiatric drug treatments, preventing dental problems and stabilizing mental state. Integrating dental care into psychiatric treatment plans ensures a holistic approach, benefiting patients with optimal oral health and a better overall quality of life. This collaboration between healthcare professionals can reduce costs associated with re-hospitalizations and complications due to oral health neglect, highlighting the need for an integrative approach in the treatment of patients with psychiatric conditions.
Published: 2024
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24. RISKS AND CONSIDERATIONS IN ORAL REHABILITATION OF ELDERLY HYPERTENSIVE PATIENTS

Author: Gabi Topor, Iulia Alecsandra Salcianu, Alina Mihaela Calin, Nicolae Sarbu, Minodora Campanu (Banu), Olimpia Dumitriu-Buzia, Solomon Sorina, Victorita Stefanescu, Norina Consuela Forna, and Iulian Catalin Bratu
Subjects: hypertension, oral health, antihypertensive drugs, management of elderly patients, Dentistry, RK1-715
Abstract: Oral rehabilitation of elderly hypertensive patients presents specific challenges, given the increased prevalence of systemic complications in this group. Hypertension can significantly influence dental management through drug interactions, oral side effects of antihypertensive therapies, and special needs during dental procedures. The complex and interdisciplinary approach to the management of oral rehabilitation of elderly hypertensive patients is essential to ensure safe and effective treatment. By implementing personalized assessment, intervention and education strategies, the quality of care provided to this group of patients can be significantly improved, optimizing treatment outcomes and improving their quality of life. This article reviews existing literature and explores the main risks and considerations for optimizing oral care in these patients.
Published: 2024
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25. INNOVATIONS IN THE TREATMENT OF PEDIATRIC CONJUNCTIVITIS: MODERN SOLUTIONS FOR SMALL PATIENTS

Author: Iulian Catalin Bratu, Irina Ruxandra Strambu, Iulia Alecsandra Salcianu, Marius Vacaru Carnaru, Olimpia Dumitriu-Buzia, Nicolae Sarbu, Ion Ciuca, Alina Mihaela Calin, Norin Forna, and Simona Parvu
Subjects: conjunctivitis, therapeutic innovations, nanoparticles, led light therapy, immunomodulatory therapy, health education, Dentistry, RK1-715
Abstract: Conjunctivitis, a common inflammation of the conjunctiva, commonly affects children and can be caused by bacterial, viral infections or allergic reactions. This condition, manifested by redness, itching, and eye discharge, can negatively influence children’s quality of life and lead to school absenteeism. In addition, the rapid spread of infection in communities such as schools and kindergartens underlines the need for effective and safe treatment solutions. This article explores recent innovations in the treatment of pediatric conjunctivitis, highlighting modern methods and advanced technologies that promise to improve the management of this condition. These innovations include state-of-the-art antibiotic and antiviral therapies, nanoparticle use, probiotics and LED light therapy applications, and new immunomodulatory strategies for allergic conjunctivitis. It also discusses the psychological impact of conjunctivitis on children and the importance of education and prevention in the management of this condition. By presenting these modern solutions, the article emphasizes the need for prompt and adequate treatment to prevent long-term complications and ensure a better quality of life for small patients. At the same time, the importance of continuous development of research and innovation in pediatric ophthalmology is emphasized.
Published: 2024
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26. How fast does the brain recover after an epileptic seizure?

Author: Ionuț‐Flavius Bratu, Samuel Medina Villalon, Elodie Garnier, Christian‐G. Bénar, and Fabrice Bartolomei
Subjects: Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429
Abstract: Abstract The postictal state, an abnormal cerebral condition following a seizure until the return to the interictal baseline, is frequently overlooked, despite often exceeding ictal duration and significantly impacting patients' lives. This study analyzes stereo‐EEG (SEEG) signal dynamics using permutation entropy to quantify recovery time (postictal alteration time – PAT) in focal epilepsy and its clinical correlations. The average PAT was 4.5 min, extending up to an hour and was highest in temporal epilepsy and hippocampal sclerosis. Correlating with age at seizure onset and at SEEG, PAT provides a solution for operationally defining the postictal state and guiding interventions.
Published: 2024
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27. Advantages of mechanical anastomosis in rectal cancer surgery

Author: Paul Șiancu, Adrian Boicean, Denisa Tănăsescu, Dan Bratu, and Ciprian Tănăsescu
Subjects: rectal cancer, mechanical anastomosis, digestive anastomoses, staplers, rectal surgery, Medicine (General), R5-920
Abstract: Rectal oncological pathology usually involves surgical treatment, which presents a relatively high degree of difficulty in terms of the surgical approach. With the development of minimally invasive surgery, technology has also diversified its possibilities for performing digestive anastomoses, noting significant advances in the techniques currently available for performing mechanical anastomoses. The evolution of mechanical sutures through the use of staplers has become a true landmark of technological progress on this topic, as they have led to significant improvements in both the operative technique and the therapeutic results obtained. The aim of this paper is to highlight the advantages of using staplers in rectal surgery, which seem to contribute to a lower percentage of postoperative complications (lower incidences of suppuration, fistulae and evisceration) and a lower rate of mortality. The use of mechanical anastomoses has also increased the technical possibilities of performing lower anastomoses, thus reducing the number of colostomies and the hospitalization period, aspects that have improved the compliance of patients who require major oncological surgical interventions.
Published: 2024
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28. Book review: Cross-border Perspectives and Interdisciplinary Approaches to Life Quality

Author: Mirela Gabriela BRATU
Subjects: cross-border, cooperation, quality of life, Social Sciences, Language and Literature
Abstract: The volume Cross-border Perspectives and Interdisciplinary Approaches of Life Quality, edited by Gina Aurora Necula, Carmelia Mariana Dragomir Bălănică, and Alexandra Monica Toma, was published in 2022 and presents a comprehensive exploration into the multiple dimensions of life quality through the lens of interdisciplinary research. The volume covers insights drawn from various academic disciplines, thus contributing to understanding life quality in the context of cross-border dynamics.
Published: 2024

29. Lumbar disc herniation

Author: Corneliu Toader, Bogdan-Gabriel Bratu, Razvan-Adrian Covache-Busuioc, Luca-Andrei Glavan, Matei Serban, and Alexandru Vlad Ciurea
Subjects: LDH, LBP, neuroimaging, microdiscectomy, endoscopic techniques, neuroplasty, Neurology. Diseases of the nervous system, RC346-429
Abstract: Lumbar disc hernia represents one of the most frequent neurosurgical pathologies, consisting of a posterior migration of the nucleus pulposus which protrudes through the surrounding protective connective tissue. The patient usually exhibits leg pain, paraesthesia or a variable degree of discomfort at the lower extremities, those clinical characteristics are correlated to the extent of nucleos pulposus protrusion. Regarding neuroimaging diagnosis, the gold standard of evaluation is Magnetic resonance imaging in different sequences which highlights a precise topography of the herniated disc. Currently, in a well-digitalized era, machine learning and deep learning algorithms are used to assess the sensibility of detecting a lumbar disc hernia, with promising results. In those cases requiring surgical intervention, besides the open lumbar microdiscectomy, a less invasive surgical approach regularly used in the medical practice is endoscopic lumbar discectomy, being limited to cases where a wide intraoperative perspective is not necessary. In the actual neurosurgical management, postoperative complications following lumbar disc hernia surgery are rare and accessible to manage.
Published: 2024

30. CURRENT STRATEGIES IN ADDRESSING MYOPIA

Author: Carmen Tiutiuca, Aurel Nechita, Laura Bujoreanu-Bezman, Dinu Bogdan Tiutiuca, Iulian Catalin Bratu, Iulia Alecsandra Salcianu, Gabi Topor, Victorita Stefanescu, Antoanela Covaci, and Ciprian Adrian Dinu
Subjects: myopia, environmental factors, axial elongation, atropine, orthokeratology, progressive contact lenses, Dentistry, RK1-715
Abstract: Myopia is a current worldwide problem, due to a marked increase in its prevalence, all the more important in the age of monitors and working predominantly indoors. This impacts in particular on visual acuity and thus on quality of life, individual performance, with consequences for the labour market and economic implications for public health services. Consequently, much research is focused on modifying the factors that determine the onset and especially the progression of myopia, using various methods, such as the use of anticholinergic agents, the use of progressive lenses (aerial or contact), orthokeratology, refractive surgery techniques, each of which has varying degrees of effectiveness. The aim of this paper is to highlight the association between myopia progression and environmental and occupational factors, and to review currently available strategies for reducing myopia progression.
Published: 2024
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31. ANALYSIS OF THE EFFECTS OF NONSTEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDS) IN THE ORAL CAVITY

Author: Gabi Topor, Aurel Nechita, Irina Ruxandra Strambu, Iulian Catalin Bratu, Simona Stefan, Minodora Campanu (Banu), Olimpia Dumitriu-Buzia, Doriana Agop Forna, and Simona Parvu
Subjects: nonsteroidal anti-inflammatory drugs (nsaids), analgesic effects, reduction of inflammation, adverse effects, drosera, essential oils, Dentistry, RK1-715
Abstract: Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used for their analgesic and anti-inflammatory effects. However, their prolonged use has been associated with adverse effects on teeth and oral tissues. Studies have shown that NSAIDs can cause oral ulceration, bleeding gums, and delayed healing of lesions in the oral cavity. NSAIDs can also affect bone metabolism, leading to osteonecrosis of the jawbone. In addition, some NSAIDs have been shown to have acidic properties that can cause erosion of tooth enamel and dentin. In dentistry, Drosera sp. has been found to exhibit several pharmacological actions such as analgesic, anti-inflammatory, and antimicrobial properties. The plant contains various phytochemical components, such as flavonoids, alkaloids, and terpenoids, which are responsible for its beneficial effects. These compounds have been shown to possess antioxidant properties, which help reduce oxidative stress and inflammation. Drosera sp. has proven to be effective against tooth decay and periodontal disease. Infections in the oral cavity and caries caused by bacteria of the Streptococcus class are very sensitive to Drosera extracts. This is due to plumbagin, which inhibits the growth and development of strains of Streptococcus mutans, Streptococcus sobrinus, Streptococcus rattus, and Streptococcus cricetus. Studies have also been conducted on pathogens involved in periodontitis and gingivitis caused by Prevotella intermedia, Porphyromonas gingivalis, and Aggregatibacter atinomycetemcomitans.
Published: 2024
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32. Deciphering Glioblastoma: Fundamental and Novel Insights into the Biology and Therapeutic Strategies of Gliomas

Author: Razvan Onciul, Felix-Mircea Brehar, Corneliu Toader, Razvan-Adrian Covache-Busuioc, Luca-Andrei Glavan, Bogdan-Gabriel Bratu, Horia Petre Costin, David-Ioan Dumitrascu, Matei Serban, and Alexandru Vlad Ciurea
Subjects: gliomas, central nervous system tumors, epidemiology, immunological milieu, tumor microenvironment, transcriptomics, Biology (General), QH301-705.5
Abstract: Gliomas constitute a diverse and complex array of tumors within the central nervous system (CNS), characterized by a wide range of prognostic outcomes and responses to therapeutic interventions. This literature review endeavors to conduct a thorough investigation of gliomas, with a particular emphasis on glioblastoma (GBM), beginning with their classification and epidemiological characteristics, evaluating their relative importance within the CNS tumor spectrum. We examine the immunological context of gliomas, unveiling the intricate immune environment and its ramifications for disease progression and therapeutic strategies. Moreover, we accentuate critical developments in understanding tumor behavior, focusing on recent research breakthroughs in treatment responses and the elucidation of cellular signaling pathways. Analyzing the most novel transcriptomic studies, we investigate the variations in gene expression patterns in glioma cells, assessing the prognostic and therapeutic implications of these genetic alterations. Furthermore, the role of epigenetic modifications in the pathogenesis of gliomas is underscored, suggesting that such changes are fundamental to tumor evolution and possible therapeutic advancements. In the end, this comparative oncological analysis situates GBM within the wider context of neoplasms, delineating both distinct and shared characteristics with other types of tumors.
Published: 2024
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33. Uterovesical Abscess as Late Cesarean Complication - a Case Report and Review of the Literature

Author: Oana Mihaela TEODOR, Delia Maria GRADINARU-FOMETESCU, Ovidiu BRATU, Florin Costel DOBRITOIU, Andreea Nicoleta MARINESCU, and Monica Mihaela CIRSTOIU
Subjects: pelvic abscess, uterovesical space, cesarean complication, Medicine, Medicine (General), R5-920
Abstract: Pelvic abscesses located in the uterovesical space usually appear postpartum after cesarean delivery. Late presentation after months or years following surgery is rarely reported, especially in immunocompetent patients. We report the case of a young patient presenting an abscess of the uterovesical pouch, infiltrated in the myometrium, posterior wall of the bladder and parametrium. The case particularities include limited identifiable predisposing risk factors, acute onset of symptoms and belated diagnosis eight years after her second cesarean. The abscess removal by laparotomy required extensive debridement, total hysterectomy, bilateral salpingectomy and partial cystectomy, with good outcome after surgical treatment. We highlight the importance of a mixt urogynecology team for individualized case management and we discuss similitudes with other late cesarean complications.
Published: 2024
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34. The Jack-in-the-Box: Pericardial Decompression Syndrome Managed by a Multidisciplinary Approach with Early Initiation of Veno-Arterial Extracorporeal Membrane Oxygenation: A Case Report

Author: Carmen Orban, Tudor Borjog, Claudia Talpau, Mihaela Agapie, Angelica Bratu, Mugurel Jafal, and Mihai Popescu
Subjects: post decompression syndrome, veno-arterial extracorporeal membrane oxygenation, cardiogenic shock, Medicine (General), R5-920
Abstract: Post decompression syndrome (PDS) is a rare and life-threatening complication of pericardiocentesis, especially after rapid drainage of large amounts of pericardial fluid. We present the case of a 21-year-old man who presented with cardiac tamponade of unknown etiology. After preoperative optimization, surgical drainage of the pericardial effusion was performed and approximately 2500 mL of fluid was released over 30 min. The patient rapidly developed hemodynamic collapse with severe biventricular dysfunction, with a left ventricle ejection fraction of 15%. Vasopressor and inotropic support were initiated with Noradrenaline and Dobutamine, further escalated to Adrenaline and Levosimendan with no improvement in clinical and hemodynamic parameters. Considering the high doses of vasoactive drugs, rescue veno-arterial extracorporeal membrane oxygenation (V-A ECMO) was started within the first 24 h. After 10 days on V-A ECMO, the cardiac function slowly recovered, and the extracorporeal mechanical support was successfully weaned. The diagnosis of paraneoplastic PDS secondary to angiosarcoma was made and the patient was successfully discharged to the ward on the 24th day. In conclusion, far from being the last option in the management of PDS, V-A ECMO deserves early consideration for securing adequate myocardial and systemic perfusion, while the cardiac function recovers, but a risk-to-benefit assessment should be made by an experienced multidisciplinary team.
Published: 2024
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35. COVID-19 and Its Potential Impact on Children Born to Mothers Infected During Pregnancy: A Comprehensive Review

Author: Cristiana Stolojanu, Gabriela Doros, Melania Lavinia Bratu, Iulia Ciobanu, Krisztina Munteanu, Emil Radu Iacob, Laura Andreea Ghenciu, Emil Robert Stoicescu, and Mirabela Dima
Subjects: maternal COVID-19 effects, fetal development, placental dysfunction, child development, Medicine (General), R5-920
Abstract: Pregnancy is a vulnerable period of time during which pregnant people are prone to infections like COVID-19, which can increase risks for both the mother and fetus. These infections may lead to complications such as preterm birth, developmental delays, and congenital abnormalities. While COVID-19 poses additional risks like placental dysfunction and neonatal infections, studies on long-term effects remain limited. Ongoing research and monitoring are essential to understand and mitigate potential cognitive and developmental challenges in children born to mothers infected with COVID-19. This review aims to guide clinicians in managing these risks throughout childhood. Maternal COVID-19 infection during pregnancy can have significant implications for fetal development, even if the newborn is not infected at birth. The release of inflammatory cytokines may cross the placental barrier, potentially disrupting fetal brain development and increasing the risk of long-term cognitive and behavioral issues, such as ADHD or autism. Placental dysfunction, caused by inflammation or thrombosis, can lead to intrauterine growth restriction (IUGR), preterm birth, or hypoxia, affecting both neurological and respiratory health in newborns. Furthermore, a compromised fetal immune system can increase susceptibility to autoimmune conditions and infections. The early diagnosis and management of infections during pregnancy are crucial in mitigating risks to both the mother and fetus. Swift intervention can prevent complications like preterm birth and long-term developmental challenges, ensuring better health outcomes for both the mother and child. Long-term monitoring of children born to mothers infected with COVID-19 is necessary to understand the full extent of the virus’s impact. This review evaluates the long-term systemic effects of maternal COVID-19 infection during pregnancy on fetuses, newborns, and children, focusing beyond vertical transmission. It highlights the broader impacts on fetal development, offering insights to help clinicians manage potential issues that may arise later in life.
Published: 2024
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36. Evaluating Quality of Life Changes over 12 Months Among Opiate Users from Romania and Associated Worsening Factors

Author: Melania Lavinia Bratu, Dorel Sandesc, Teodora Anghel, Felix Bratosin, Silviu Valentin Vlad, Artiom Terzi, and Caius Glad Streian
Subjects: quality of life, psychiatry, opiate, drug abuse, Science
Abstract: This study aimed to evaluate the changes in quality of life (QoL) over a 12-month period among opiate users in Romania, identifying factors that contribute to a worsening of their condition. By examining these dynamics, the research intended to inform targeted interventions and support mechanisms to mitigate the negative outcomes associated with opiate use. Conducted as a longitudinal cohort analysis, this study enrolled 74 participants diagnosed with opioid use disorders from multiple healthcare settings in Romania. The WHOQOL-BREF instrument was utilized to assess QoL, with data collection spanning from 1 January 2023 to 31 December 2023. Ethical compliance with the Declaration of Helsinki was maintained, and participants provided informed consent. Statistical analysis was performed using SPSS, focusing on the impact of demographic and behavioral variables on QoL. Over the 12-month period, significant improvements were observed in all QoL domains: physical (51.68 to 58.39, p < 0.001), psychological (49.34 to 55.32, p < 0.001), social (46.21 to 53.66, p < 0.001), and environmental (47.85 to 54.17, p < 0.001). Methadone compliance significantly influenced positive outcomes across all domains. Compliant participants exhibited higher mean scores compared to non-compliant users, with respective increases in the physical domain from 52.47 to 60.21 (p < 0.001), psychological from 50.93 to 58.32 (p < 0.001), social from 48.36 to 57.14 (p < 0.001), and environmental from 47.82 to 55.79 (p < 0.001). Additionally, education showed a protective effect, particularly enhancing environmental QoL (estimate = 0.33, p = 0.013). Methadone compliance and higher education levels were identified as significant predictors of improved QoL among opiate users, demonstrating the critical importance of adherence to treatment protocols and the supportive role of education in enhancing life quality. These findings highlight the necessity for integrated treatment programs and educational interventions to improve the well-being of individuals battling opioid addiction, advocating for policy enhancements and supportive measures tailored to this demographic.
Published: 2024
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37. Cardiovascular Risk Factors as Independent Predictors of Diabetic Retinopathy in Type II Diabetes Mellitus: The Development of a Predictive Model

Author: Cristian Dan Roşu, Melania Lavinia Bratu, Emil Robert Stoicescu, Roxana Iacob, Ovidiu Alin Hațegan, Laura Andreea Ghenciu, and Sorin Lucian Bolintineanu
Subjects: diabetic retinopathy, type 2 diabetes mellitus, cardiovascular risk factors, predictive model, blood pressure, BMI, Medicine (General), R5-920
Abstract: Background: Diabetic retinopathy (DR) is a leading cause of blindness in patients with type 2 diabetes mellitus (T2DM). Cardiovascular risk factors, such as hypertension, obesity, and dyslipidemia, may play a crucial role in the development and progression of DR, though the evidence remains mixed. This study aimed to assess cardiovascular risk factors as independent predictors of DR and to develop a predictive model for DR progression in T2DM patients. Methods: A retrospective cross-sectional study was conducted on 377 patients with T2DM who underwent a comprehensive eye exam. Clinical data, including blood pressure, lipid profile, BMI, and smoking status, were collected. DR staging was determined through fundus photography and classified as No DR, Non-Proliferative DR (NPDR), and Mild, Moderate, Severe, or Proliferative DR (PDR). A Multivariate Logistic Regression was used to evaluate the association between cardiovascular risk factors and DR presence. Several machine learning models, including Random Forest, XGBoost, and Support Vector Machines, were applied to assess the predictive value of cardiovascular risk factors and identify key predictors. Model performance was evaluated using accuracy, precision, recall, and ROC-AUC. Results: The prevalence of DR in the cohort was 41.6%, with 34.5% having NPDR and 7.1% having PDR. A multivariate analysis identified systolic blood pressure (SBP), LDL cholesterol, and body mass index (BMI) as independent predictors of DR progression (p < 0.05). The Random Forest model showed a moderate predictive ability, with an AUC of 0.62 for distinguishing between the presence and absence of DR XGBoost showing a better performance, featuring a ROC-AUC of 0.68, while SBP, HDL cholesterol, and BMI were consistently identified as the most important predictors across models. After tuning, the XGBoost model showed a notable improvement, with an ROC-AUC of 0.72. Conclusions: Cardiovascular risk factors, particularly BP and BMI, play a significant role in the progression of DR in patients with T2DM. The predictive models, especially XGBoost, showed moderate accuracy in identifying DR stages, suggesting that integrating these risk factors into clinical practice may improve early detection and intervention strategies for DR.
Published: 2024
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38. Insights into the Cytotoxicity and Irritant Potential of Chlorhexidine Digluconate: An In Vitro and In Ovo Safety Screening

Author: Stefania Dinu, Anamaria Matichescu, Roxana Buzatu, Iasmina Marcovici, Andreea Geamantan-Sirbu, Alexandra Denisa Semenescu, Remus Christian Bratu, and Dana-Cristina Bratu
Subjects: chlorhexidine digluconate, cutaneous cells, cytotoxicity, dentistry, gingival fibroblasts, irritant potential, Dentistry, RK1-715
Abstract: Chlorhexidine (CHX) represents one of the most commonly used antiseptics in dentistry and other medical–pharmaceutical fields due to its broad-spectrum antimicrobial activity. However, the potential toxic events arising from its common use in practice has become a subject of increasing concern. Thus, the present study was designed to investigate the potential toxicity of CHX digluconate at concentrations covering its antibacterial properties (0.0002–0.2%) in HGF primary gingival fibroblasts, HaCaT immortalized human keratinocytes, and JB6 Cl 41-5a epidermal cells, as well as its irritant action in ovo. Our results indicate that CHX exerted a concentration- and time-dependent cytotoxicity in all cell lines, which was evidenced by the reduction in cell viability, number, and confluence, damaged cell membrane integrity, impaired cell morphology, and specific apoptotic nuclear shape. The highest cytotoxicity was caused by CHX digluconate 0.02% and 0.2%, concentrations, at which an irritant effect on the chorioallantoic membrane was also observed. The novel findings revealed in this research contribute to the overall safety profile of CHX and stand as a basis for further investigations in this regard.
Published: 2024
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39. Access to and quality of elective care: a prospective cohort study using hernia surgery as a tracer condition in 83 countries

Author: Dönmez, A Eylül, Goswami, Aakansha Giri, Raheja, Aashna, Bhadani, Aayush, El Kady, Abd Elrahman Safwat, Alniemi, Abdalaziz, Awad, Abdalkarim, Aladl, Abdalla, Younis, Abdalla, Alwali, Abdallah, Khalil, Abdallah, Mansour, Abdallah, Elkhouly, Abdallah Mohamed, Rashad Temerik, Abdallah, Hasan, Abdallatef, Chied, Abdelhafid, Abdraba, Abdelhamid, Hrora, Abdelmalek, Abdelshafi, Abdelrahman, Alwali, Abdelrahman, Maraqa, Abdelrahman, Ghaffar, Abdul, Chekfa, Abdul Jabar, Al Balushi, Abdul Majeed, Quddus, Abdul, Hammadieh, Abdul Rahman, Muntaka, Abdul-Jalilu Mohammed, Asekun, Abdulazeez, Alshahrani, Abdulaziz, Jowharji, Abdulaziz, Alshukre, Abdulbaset, Khair Etareig, Abdulhafid, Abubakar Abdulkarim, Abdulhafiz, Ashiru, Abdulhafiz, Alailesh, Abdulhamid, Al-Mallah, Abdullah, Baydoun, Abdullah, Chaudhry, Abdullah, Askin, Abdullah Emre, Almutairi, Abdulmjeed, Belkhair, Abdulmunem, Abdllah, Abdulrahman, Alhammali, Abdulrahman, Basalim, Abdulrahman, Abouelnagah, Abdulrahman Galal Mohamed Mostafa, Ghazal, Abdulrahman, Mohammed, Abdulrahman, Qasem, Abdulrahman, Anadani, Abdulrazak, Jimoh, Abdulrazaq, Lawal, Abdulrazzaq Oluwagbemiga, Khaity, Abdulrhman, Lawal, Abdulwahab, Elzoubi, Abdurrahim Esseid, Sheshe, Abdurrahman Abba, Cetişli, Abdurrahman Furkan, Oyedele, Abeeb, Aljahdali, Abeer, Aboelnasr, Abeer Gamal Elsyed, Demessie, Abel, Bhargava, Abhilasha, Sonkar, Abhinav Arun, Bavaharan, Abhirame, Khan, Abid, Campbell, Abigail, Oyelekan, Abimbola Adeola Akintunde, Okunlola, Abiodun Idowu, Ojewuyi, Abiodun, Ekerin, Abiola, Saleh, Abobakr, Khairy, Abouelatta, Muthunayagam, Abraham Benjamin, Botha, Abraham, Teshome Sahilemariam, Abraham, Nawawi, Abrar, Muhammad, Abubakar Bala, Dahiru, Abubakar, Yahaya, Abubakar, Abdelmalik, Abubaker, Anuar, Abul Akmal Arif, Ousseini, Adakal, Leon -Del- Angel, Adalberto, Frankel, Adam, Gyedu, Adam, Lim, Adam, Lukáč, Adam, Peckham-Cooper, Adam, Sabbah, Adam, Varga, Adam, Sanou, Adama, Issaka, Adamu, Ningi, Adamu, Yeshitila, Addis, Yingess, Addisu, Olugbami, Adebayo, Moses, Damola-Okesiji, Adebola, Lawal, Adedayo, Ojo, Adedoyin, Hashmi, Adeel, Fakoya, Adegbolahan, Ishola, Adegoke, Abiodun, Adekunle, Ajayi, Adekunle, Mouffokes, Adel, Bonelli, Adele, Adekoya, Adeleke, Akeem Aderogba, Adeleke, Özcan, Adem, Ayoade, Ademidun, Adeyeye, Ademola, Agbaje, Ademola, Talabi, Ademola, Ademuyiwa, Adesoji, Adewumiya, Adesoji, Ademuyiwa, Adesoji O, Aderounmu, Adewale, Adisa, Adewale, Oke, Adewale, Ragab, Adham, Alzadjali, Adil, Baksi, Aditya, Jayapalan, Aditya, Md Yunos, Adnan, Pisanu, Adolfo, Salazar, Adolfo, Salinas Barragan, Adrian Alberto, Fox, Adrian, Stollberg, Adrian, Franco, Adriana, Neves, Adriana, Vricheva, Adriana, Hodonou, Adrien Montcho, Aghayeva, Afag, Liaquat, Affifa, Alsultan, Afnan, Morad, Afnan, Kalidis, Afroditi Angella, Gkouniaroudi, Agathi, Karakosta, Agathi, Lovi, Agbenya, Yevide, Agossou Barthélémy, Duro, Agustin, Rodriguez Gonzalez, Agustin, Tariq, Ahbala, Abaidalla, Ahmad, Abuhammad, Ahmad, Abuhantash, Ahmad, Mansour, Ahmad Adel, Ahmad Zaidi, Ahmad Al Hafeez, Alahmad Alismael, Ahmad, Alayed, Ahmad, Alfarwan, Ahmad, Alhaj, Ahmad, Ali, Ahmad, Alroobi, Ahmad, Alsheikh, Ahmad, Alusef, Ahmad, Alzu'Bi, Ahmad, Kayali, Ahmad Amir, Bouhuwaish, Ahmad, Doghaim, Ahmad, El-Sherbiney, Ahmad, Ghazal, Ahmad, Ramly, Ahmad Nasir, Raza, Ahmad, Qureshi, Ahmad Uzair, Arnaout, Ahmad Yamen, Abdelhamid, Ahmed, Abuthaher, Ahmed, Adel, Ahmed, Ahmayda, Ahmed, Al-Mouahhed, Ahmed, Alagha, Ahmed, Albalawi, Ahmed, Albhaisi, Ahmed, Alrifaee, Ahmed, Azam, Ahmed, Barakat, Ahmed, Al-Hajjaj, Ahmed Basim Abed, Dawoud, Ahmed, El Shamarka, Ahmed, El-Bastwesy, Ahmed, Elghrieb, Ahmed, Elkhalifa, Ahmed, Elmosalamy, Ahmed, Elshazli Mahmoud, Ahmed, Montaser, Ahmed G., Gbeadese, Ahmed, Haty, Ahmed, K. Ali, Ahmed, Awad, Ahmed K., Kedwany, Ahmed, Khalleefah, Ahmed, Abbas, Ahmed M., Allam, Ahmed M., Maher, Ahmed, Elsayed, Ahmed Mohamed, Mohamed Ibrahim Mohamed, Ahmed, Mostafa, Ahmed, Nabil, Ahmed, Nada, Ahmed, Ragheb, Ahmed, Abdelrahman, Ahmed Saber Mohamed, Sabry, Ahmed, Sakr, Ahmed, Elkhodary, Ahmed Salah, Shaheen, Ahmed, Ammar, Ahmed Siddique, Hameed, Ahmer, Akmercan, Ahmet, Aslan, Ahmet, Barcin, Ahmet, Ciftci, Ahmet Burak, Bozkurt, Ahmet Çağlar, Sarı, Ahmet Can, Yaşar, Ahmet Can, Develioğlu, Ahmet, Öztürk, Ahmet Mücteba, Sanli, Ahmet Necati, Rencuzogullari, Ahmet, Yildiz, Ahmet, Kaan, Ahmet Zahit, Toi, Ahouefa Chourika Sakinath, Aljamoudi, Aida, Cheung, Aiden Chak Kei, Gkoutoula, Aikaterini, Kalogeropoulou, Aikaterini, Sarafi, Aikaterini, Abo Al Shamat, Aiman, Sanon, Aimé Serge Titianma, Sanon, Aimée Florence, Hiller, Aimée, Costas-Chavarri, Ainhoa, Lombardero, Ainhoa, Fraile, Ainoa, Bojazyah, Aisha, Kamal, Aisha, Gill, Aisling, Hada, Aïssatou, Gulla, Aiste, Mačiulaitytė, Aistė, Sukumar, Aiswarya, Landaluce-Olavarria, Aitor, Sainz Lete, Aitor, Pal, Ajay Kumar, Malik, Ajaz Ahmad, Horiguchi, Akihiko, Kocaay, Akin Firat, Akinkuolie, Akinbolaji, Olabode, Akingunloye, Fadipe, Akinniyi, Akinmade, Akinola, Darkwa Boateng, Akosua, Appiah-Kubi, Akosua Yeboaa, Alkaseek, Akram, Kadamani Abiyomaa, Akram, Anand, Akshay, Oppong, Akua, Opoku-Agyapong, Akwasi, Asharaf, Al Ameen, Ahmed, Al Samoul, Andani, Al-Hassan Dasana, Alkharusi, Al-Salt, Abd Elsattar, Alaa, Alragheai, Alaa, Alsalahat, Alaa Atta, Hawarah, Alaa, Aldirani, Alaa Nasib, Shabkah, Alaa, Nixon Fulli, Alafi Francis, Nguyen, Alain, Mustafa, Alamin, Joseph, Alan, Huws, Alaw, Aregawi, Alazar Berhe, Sanchez Gallego, Alba, Torroella, Alba, Vazquez Melero, Alba, Dauksa, Albertas, Abreu Da Silva, Alberto, Brun-Peressut, Alberto, Barranquero, Alberto G, Gegúndez Simón, Alberto, Gerundo, Alberto, Navarrete-Peón, Alberto, Viacava, Alberto, Vilar, Alberto, Adam, Albushra Altayeb, Jarimba, Aldo, Johnson, Aleena, Nuñez Venzor, Alejandra, Gonzalez Ojeda, Alejandro, Romero De Diego, Alejandro, Karamarkovic, Aleksandar, Butyrskii, Aleksandr, Edmundson, Aleksandra, Sidorova, Aleksandra, Thomas, Alen, Tomazic, Ales, Giuliani, Alessandra, Iodice, Alessandra, Marano, Alessandra, Marello, Alessandra, Ongaro, Alessandra, Saba, Alessandra, Anastasi, Alessandro, Borello, Alessandro, Broglia, Alessandro, Carta, Alessandro, Finocchio, Alessandro, Francia, Alessandro, Iacomino, Alessandro, Izzo, Alessandro, Ottaiano, Alessandro, Spaziani, Alessandro, Strumia, Alessandro, Biancafarina, Alessia, D'Ignazio, Alessia, Davolio, Alessia, Morello, Alessia, Licciardello, Alessio, Mazzoni, Alessio, Wilkins, Alex, Arekhandia, Alexander, Barlas, Alexandros, Chamzin, Alexandros, Demetriou, Alexandros, Giakoustidis, Alexandros, Kozadinos, Alexandros, Kyriakidis, Alexandros, Sarakatsanos, Alexandros, Rojas, Alexei, Saridaki, Alexia, Litchinko, Alexis, Arnaud, Alexis P, Binder, Alf-Dorian, Yakubu, Alfa, Kavalakat, Alfie, Shamsutdinova, Alfiya, Alberico, Alfonso, Amendola, Alfonso, Sánchez-Terán, Alfonso Iván, Lapergola, Alfonso, Baiden Amissah, Alfred, Königsrainer, Alfred, Twumasi, Alfred, Alhebshi, Alhasan, Abbas, Ali, Abdul Rahman, Ali, Abidali, Ali, Abu Tair, Ali, Ahmad, Ali, Al Mukhtar, Ali, Sharq, Ali Al, Alloush, Ali, Amaigl, Ali, Kheirkhah Vakilabad, Ali Asghar, Bassma, Ali, Hacioglu, Ali Doruk, Elzanaty, Ali, Fani, Ali, Farsi, Ali, Ghummied, Ali, Hajali, Ali, Al Sharqi, Ali Hamed, Hammed, Ali, Hewari, Ali, Isler, Ali, Marouf, Ali, Uysal, Ali Mert, Murtada, Ali, Syed, Ali Naqi, Ozkomec, Ali, Sapmaz, Ali, Wassouf, Ali, Aldurssi, Alia, Polatbekov, Alibek, Caltagirone, Alice, Gori, Alice, Lim, Alicia, Bhatt, Alisha, Mohammed, Aljarrah, Maxwell, Allison, Kiyabayev, Almaz, Eltayeb, Almoutaz, Khamees, Almu'atasim, Abdalla, Alnazir, Pikarsky, Alon, Trigos Díaz, Alonso, A Elhars, Alshymaa, Alhaj Zain, Altayeb, Eltahir, Altayeb, Robin Valle De Lersundi, Alvaro, Sanad, Aly, Abdalhadi, Alya, Sparke, Alyssa, 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Daniel, Montwedi, Daniel, Muñoz, Daniel, Patterson, Daniel, Reim, Daniel, Agbley, Daniel Yao Dodzie, Patiño García, Daniela Cristina, Di Pietrantonio, Daniela, Pais, Daniela, Rosado, Daniela, Tavares, Daniela, Alberti, Daniele, Fusario, Daniele, Massaro, Daniele, Paglione, Daniele, Pironi, Daniele, Kurochka, Daniil, Centonze, Danilo Corrado, Hackner, Danilo, Herrera, Danilo, Amangaliyev, Daniyar, Silva-Cano, Danny Wladimir, Chaudhry, Daoud, Palmisano, Dario, Ribero, Dario, Vukosav, Dario, Misca, Darius, Lowen, Darren, Rattray, Darren, Walia, Darshanjit Singh, Maan, Darvesh, Muyenzi, Daryle, Verdi, Daunia, Bardsley, David, Reyes Rodríguez, David Estuardo, Fra Corral, David, Garcia López De Goicoechea, David, Gavit, David, Gómez, David, Idowu, David, Konkin, David, Labadah, David Kplorla Kekeli, Liu, David, Merlini, David, Mitchell, David, Moro-Valdezate, David, Osifo, David, Proud, David, Ridder, David, Gobatti, Davide, Muschitiello, Davide, Pertile, Davide, Zulian, Davide, Mengiste, 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Elizabeth, Torres De Anda, Elizabeth Magaly, Murphy, Elizabeth Mary Ann, O'Connell, Elizabeth, Redondo, Elizabeth, Lun, Elizabeth Weng Yan, Francis, Ella, Haiden, Elmar, Hamed, Elmonzir, Alkhalifa, Elmustafa, Dexter, Eloise, Daketsey, Elorm, Setsoafia, Elorm, Mohamed, Elsagad, Mohammed, Elsamoual, Hegab, Elsayed, Ay, Elvin, Adinolfi, Elvira, Mbanzabugabo, Elvis, Chin, Elynn, Ahmed, Emad Ali, Younes, Eman, Basile, Emanuela, Gessa, Emanuela, Pontecorvi, Emanuele, Romairone, Emanuele, Hatangimana, Eméry, Ndizeye, Emile, Ciofic, Emilia, Dijan, Emilio, López-Negrete Cueto, Emilio, Baker, Emily, Reid, Emily, Schmidt, Emily, Alić, Emir, Bičakčić, Emir, Agbowada, Emma, Colton, Emma, Downing, Emma, Haege, Emma, O'Neill, Emma, Roussos, Emmanouel, Nachelleh, Emmanuel Aadereyir, Adebunmi, Emmanuel, Obiesie, Emmanuel Ahuizechukwu, Akakpo, Emmanuel Bismark, Konlan, Emmanuel Dammigu Francis, Nwangwu, Emmanuel Ifeanyi, Kafui Ayodeji, Emmanuel, Ofori, Emmanuel Owusu, Spanoudakis, Emmanuel, Abate, 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N, Felix, Alahmad, Feras, Alnimri, Feras, Haddad, Feras, Gool, Ferhana, Castro, Fernanda, Diaz, Fernanda, Lucero, Fernanda, Vovola, Fernanda, Mahnic, Fernando, Mercado Sanchez, Fernando, Prieto La Noire, Fernando, Soggiu, Fiammetta, Tsige, Fikreab, Brzeszczyński, Filip, Rudisch, Filip, Valente Costa Pinto, Filipa, Ramalho De Almeida, Filipe, Banchini, Filippo, Palomino Escalante, Fiorella, Fadzlullah, Fitri, Terefe, Fitsum, Sulo, Fjorenta, Ciccarone, Flavia, Tirelli, Flavio, Krämer, Florian, Grama, Florin, Spanos, Foivos, Solimene, Folco, Akinwande, Foluso, Osman, Forzia, Stefou, Foteini, Kyramargios, Fotios, Stavratis, Fotios, Alassani, Fousseni, Ascari, Francesca, Cammelli, Francesca, D'Agostino, Francesca, Tropeano, Francesca Paola, Peters, Francesca, Ré, Francesca, Brucchi, Francesco, Casti, Francesco, Coratti, Francesco, Ferrara, Francesco, Floris, Francesco, Izzo, Francesco, Maffei, Francesco, Palmieri, Francesco, Pata, Francesco, Porcelli, Francesco, Selvaggi, Francesco, 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Judy, Mühlhäusser, Julia, Sidorovskaia, Julia, Carrizo, Julian, Napoli, Juliana, Pereira-Macedo, Juliana, Ribeiro, Juliana, De Deken, Julie, Nnoli, Juliet, Paredes, Julieta, Zevallos-Quiroz, Julio Cesar, Gonzalez Garcia, Julio, Adjei, Julius, Olaogun, Julius, Kutkevičius, Juozas, Metzger, Jürg, Košir, Jurij Aleš, Kosir, Jurij, Seyi-Olajide, Justina, Zajac, Justyna Karolina, Dhima, Jyoti, Dhiman, Jyoti, Shreyas, K, Türker, Kadir Yağız, Lee, Kai, Khutsishvili, Kakhi, Yu, Kam Keung Auston, Das, Kamala, Özdoğan, Kamil, Reddy, Kamireddy Madana Raghava, Kabulov, Kamran, Nahar, Kamrun, Rajaratnam, Kanapathippillai, Wijesinghe, Kanchana, Sevnaran, Kapil, Khalil, Karam, Singh, Karanbir, Fayed, Kareem, Booyse, Karien, Geiger-Timm, Karin, Maharaj, Karl, Bhutia, Karma, Richter, Karolina, Komorowska, Katarzyna, Urbańska, Katarzyna, Waddell, Kate, Kambouri, Katerina, Tata, Katerina, Richetti, Katharina, Griffin, Katherine, McKenzie, Katherine, Tambudze, Katherine, Hall, Katheryn, Chu, Kathryn, Theodoropoulou, Katina, Kröning, Katrin, Bozada-Gutiérrez, Katya, Raghuwanshi, Kaustubh, J B, Kavitha, Ahmed Ibrahim, Kefah, Bwala, Kefas John, Iles, Kelly, Jasso García, Kelvin, Oğur, Kemal, Fretwell, Kenneth, Oluchukwu, Kenneth, Onyekachi, Kenneth, Voon, Kenneth, Oderoha, Kevin Ewomazino, Nieto Yrigoin, Kevin, Quispe De La Roca, Kewin, Anaam, Khadega, Bensmain, Khadija, Shwail, Khadija, Akter, Khadiza, Sawaftah, Khaled Ahmad, Shamiyah, Khalid Adnan, Bhatti, Khalid, Mohammed, Khalid Miftah Ghuraybeel, Ayyoub, Khalil, Cholah, Khalil, Rahman, Khandakar Rezwanur, Abdulrahman, Khawla, Al-Shami, Khayry, Hayat, Khizar, Al Hinai, Khulood, Taghavi, Kiarash, Shodunke, Kikelomo, Abo Zaal, Kinaz, Ewool, Kingsley, Gaikwad, Kiran, Shemyatovsky, Kirill, Dey, Kirsty Elaine, Mishra, Kirti Kumar, Rathod, Kirtikumar J, Senanayake, Kithsiri Janakantha, Noguchi, Kiyonari, Kordeni, Kleoniki C., Dembele, Klétigui Samuel, Spassov, Kolyo, Khalid, Komal, Petrenko, Konstantin, Bekiaridou, Konstantina, Rekouna, Konstantina, Athanassiou, Konstantinos, Avgerinos, Konstantinos, Bouchagier, Konstantinos, Bouliaris, Konstantinos, Bramis, Konstantinos, Iliakopoulos, Konstantinos, Kontzoglou, Konstantinos, Ntatsis, Konstantinos, Pavlopoulos, Konstantinos, Perivoliotis, Konstantinos, Polychronopoulos, Konstantinos, Giannakopoulos, Konstantinos S., Zakkas, Konstantinos, Zapsalis, Konstantinos, Koumarelas, Konstantinos-Eleftherios, Mori, Krinal, Ooi, Krisada, Ascencio Diaz, Kriscia Vanessa, Jasaitis, Kristijonas, Nieuwenhuys, Kristin, Atherton, Kristy, Smith, Kristy, Sharma, Kruti, Jaffry, Kumail, Lehmann, Kuno, Ayad, Kusay, Luthra, Kush Kumar, Nanayakkara, Kushan, Agbedinu, Kwabena, Oduro-Boateng, Kwaku Boakye, Boakye-Acheampong, Kwame, Sim, Kwang Kiat, Yalley, Kwekuma, Collins, Kyeremeh, Muscat, Kyle, Hofmann, Kyra, Lambri, Kyriaki, Bananis, Kyriakos, Nassim, Kyrillos, Allan, Lachlan, Codina Corrons, Laia, Hijazein, Laith, Moolla, Laith, Sweidan, Laith, Rai, Lajpat, Devi, Lakshmi, Fountoulis, Lampros, Andreski, Lara, Bonello, Lara, Rodrigues Madeira, Lara, Tafesh, Lara, Yasin, Lara, Martinez, Laura, Fortuna, Laura, Peña Balboa, Laura Gabriela, García-Zambrano, Laura, Bolaños, Laura Isabela, Jiménez, Laura, Lely, Laura, Ortega Lechuga, Laura, Rossi, Laura, Rubin, Laura, Ruiz-Villa, Laura, Sequi, Laura, Sahan, Laura-Ann, Johnstone, Lauren, Monteiro, Lauren, Abdullahi, Lawal Barau, Jovcheski, Lazo, Siragusa, Leandro, Kang, Leannedra, Elgebaly, Leenah, Mansour, Lefteris, Robine-Durnell, Lélia, Bray, Lemuel Davies, Mohammed, Lena, Licari, Leo, Onyebulu, Leonard, Chieng, Leonard Ron, Solaini, Leonardo, Chardalias, Leonidas, Fountarlis, Leonidas Ilias, Van Den Hil, Leontine, Tapia Moral, Leopoldo, Petashvili, Leri, Heeren, Letícia, Laface, Letizia, Niyidukunda, Lewis, Barnard, Liam, Torres Bavestrello, Lidice Veronica, Hasan, Lilav, Dyab, Lima, Venclauskas, Linas, Beukes, Linda, Gabellini, Linda, Liepa, Linda, Zeng, Lingjuan, Dubs, Linus, Rampersad, Lisa, Catozzi, Livio, Castro, Lizeth, Milic, Ljiljana, Shawesh, Lobna, Anyanwu, Lofty-John, Khalifa, Lojina, Cheng, Lok Pong, Manoj Joshua, Lokavarapu, Shammas, Lora, Fuentes Rivera Lau, Lorena, Rodríguez Gómez, Lorena, Capello, Lorenzo, Epis, Lorenzo, Fatucchi, Lorenzo Maria, Rende, Lorenzo, Ripamonti, Lorenzo, Ackam, Louis, Moniz, Lourenço, Bains, Lovenish, Alriyami, Lubna, Alokshi, Lubnah, Martinek, Lubomir, Tulinsky, Lubomir, Samison, Luc, Lo Piccolo, Luca Benedetto, Cardinali, Luca, Nespoli, Luca Carlo, Casingena, Luca, Degrate, Luca, Bonomo, Luca Domenico, Morelli, Luca, Ottaviani, Luca, Resca, Luca, Scaravilli, Luca, Schiavone, Luca, Theuil, Luca, Casalduero, Lucas, Lee, Lucas D., Granero, Lucas, Caram, Lucas Jose, Barni, Lucia, Cidade Costa, Luciana, Paredes, Luciana, Poggi, Luciano, Marquez, Lucila, Garciandia, Lucio, Taglietti, Lucio, Pramod, Ludiya, Stella, Ludovica, Carbone, Ludovico, Bracciano, Luigi, Cobellis, Luigi, Conti, Luigi, Fedele, Luigi, Ragazzini, Luigi, Simonelli, Luigi, Verre, Luigi, Flores Chávez, Luis Adrián, Rea Bocanegra, Luis Alberto, Pelayo Orozco, Luis Ángel, Asensio Gomez, Luis, Bravo, Luis, Flores Chávez, Luis Manuel, Poggi, Luis, Cabezudo, Luis Ramón, Sante Serna, Luis, Tallon-Aguilar, Luis, Talé-Rosales, Luis-Fernando, Chantada, Luisa, Moreira, Luísa, Hasan, Lujain, M Mheidat, Lujain, Eisner, Lukas, Gantner, Lukas, Havranek, Lukas, Majerčák, Lukáš, Pánči, Lukáš, Nawacki, Łukasz, Adagrah Aniakwo, Luke, Bromley, Luke, Green, Luke, Paterson, Luke, Peters, Luke, Abdur-Rahman, Lukman, Omomeji, Lukman, Amosu, Lukmon, Kolongi, Lungushinga Christopher, Bin Aizan, Luqman Naim, Imchen, Lurong, Chang, Lydia, Mukamazera, Lydie, Katsiaras, Lykoyrgos, Al-Boukhari, Lynn, Chong, Lynn, Karydakis, Lysandros, Peris, M. Roosindu, Cancelas, Mª Dolores, Kariem, Maahir, Amoako-Boateng, Mabel, Alshamikh, Mabroukah, Ishak, Mabruok, Narayanan, Machingal, Matyja, Maciej, Walędziak, Maciej, Zounon, Mack-Arthur, Trindade, Madalena, Shahid, Madeeha, Kelly, Madeleine, Bajwa, Madiha, Bowles, Madison, Roussos, Madison, Sampaio-Alves, Mafalda, Manfredini, Magda, Kołomańska, Magdalena, Redynk, Magdalena, Farooq, Maham, Ali, Mahamudu Ayamba, Rodha, Mahaveer Singh, Alsalawi, Mahdi, Lodha, Mahendra, Sethi, Mahesh Kumar, Khalil, Mahfoud, Singh, Mahima, Abdualqader, Mahmmoud yehia, Abdelhafez, Mahmood, Sersarah, Mahmood, Abdelreheem, Mahmoud, Abu Al Amrain, Mahmoud, Barbarawi, Mahmoud, Diab, Mahmoud, Eissa, Mahmoud, ElFiky, Mahmoud, Elmesalmi, Mahmoud, Elmousili, Mahmoud, Fahmy, Mahmoud, Faisal, Mahmoud, Jabal, Mahmoud, Saad, Mahmoud M., Mahafdah, Mahmoud, Marei, Mahmoud Marei Abdelaziz, Mostafa, Mahmoud, Reda, Mahmoud, Zahran, Mahmoud, Suleman, Mahmowd, Genç, Mahmut Salih, Haghighat Ghahfarokhi, Mahta, Abubakar, Maimuna, Haimona, Mairarangi, Camuera, Maite, H. Oweidat, Majd, Mansour, Majd, Kalabić, Majda, MohammedAli, Majdeddin, Abu Daoud, Majdi, Almahjoub, Majdolin, Bilfaqirah, Majed, Yigah, Makafui, Akkawe, Malak, Dery, Malcolm, West, Malcolm, Rius, Malena, Nandasena, Malith, Aljarawn, Mallak, Masaaod, Mallak, Manangi, Mallikarjuna, Windsouri, Mamadou, Battili, Mamata, Rakotonaivo, Mamisoa Judicaël, Benghazi, Manaji, Al-Dhaheri, Manal, Almaqrahi, Manal, Katif, Manal, Alshami, Manar, Ibrahim, Manar, Ramazanov, Manas, Kaur, Mandeep, Agrawal, Manish Kumar, Pathak, Manish, Aggarwal, Manisha, Chandrasegaram, Manju, Anandan, Manoj, K S D, Manoj Kishan Lal, Kumar, Manoj, Sarda, Manoj, K B, Manojkumar, Jokubauskas, Mantas, Moreno Gonzales, Manuel Arturo, Cruz, Manuel, Diez Alonso, Manuel, Garcia, Manuel, Perez, Manuel, Mosquera Paz, Manuel Santiago, Cammelli, Manuela, Mercurio, Manuela, Singh, Manvinder, Taamreh, Manwa, Canals Sin, Mªpilar, Carbonell Pradas, Mar, Nunes, Mara, Sawaftah, Marah Ahmad, Khalil, Maram, Schneider, Marcel André, Steffani, Marcella, Pisano, Marcello, Doniquian, Marcelo Alejandro, Martínez Bareiro, Marcelo Nicolás, Pagani, Marcelo, Scortechini, Marcelo, Carvalho, Márcia, Sánchez Audelo, Marco Antonio, Brizzolari, Marco, Ceresoli, Marco, De Prizio, Marco, Amisano, Marco Francesco, Gramellini, Marco, Marcianò, Marco, Mariani, Marco, Milone, Marco, Montagna, Marco, Piccino, Marco, Santos, Marco, Dyer, Marcus, Kang, Marcus, Mahadi, Mardhiana, Zawadzki, Marek, Yinusa, Margaret, Bernardo, Margarida, Nunes Luís, Margarida, Gambelli, Margherita, Flint, Margot, Aggelidou, Maria, Bequis, Maria Agustina, Sotiriou, Maria Aikaterini, Ñañez, Maria Alejandra, Tahir, Maria Ambreen, Gascón Domínguez, María Ángeles, Asimakidou, Maria, Mourato, Maria Beatriz, Blanco, Maria, Christou, Maria, Coronas Soucheiron, Maria, Pignanelli, Maria Costanza, Kalaydjian, María Cristina, Martí-Ejarque, Maria del Mar, Olmedo Reinoso, María Del Mar, Cebollero, María Del Pilar, Derattani, Maria, Gama Caldeira, Maria Do Carmo, Drogouti, Maria, Gonzalez-Gonzalez, Maria Elena, Muñoz Fernández, María Elena, Muriel, María Emilia, Duran, María Eugenia, Zarate Casas, María Fernanda, Florou, Maria, Piacentini, Maria Gaia, Seixo, Maria Inês, Bellini, Maria Irene, Peña Soria, Maria Jesús, Martínez, María José, Medina, Maria José, Rueda Medécigo, María José, Karakeke, Maria, Kausar, Maria, Kyriazi, Maria, Marqueta De Salas, Maria, Modolo, Maria Marta, Mateu, Maria, Mavri, Maria, El Ghoul Miliotou, Maria Melina, Moreno Gijon, Maria, Papadoliopoulou, Maria, Proclamà, Maria Pia, Picciochi, Maria, Reis, Maria, Rennis, Maria, D'Anna, Maria Rosa, Ruffoli, Maria, Ruiz Soriano, María, Sánchez Ramirez, Maria, Sánchez-Rubio, María, Schüler, Maria, Sotiropoulou, Maria, Barrio Renteria, Maria Teresa, Tsopozidi, Maria, Vasconcelos, Maria, Facchino, Maria Vittoria, Wikar, Maria, Aguilera-Arevalo, Maria-Lorena, Abdu, Mariam, Asarbakhsh, Mariam, Elmiesiry, Mariam, Ashong, Marian Esi, Gomes, Mariana, Capuano, Marianna, Lill, Marianne, Nieto Galvan, Mariano, Osso, Mariasara, Olivos, Maricarmen, Sacdalan, Marie Dione, Weber, Marie-Christin, Gonzalez, Marijose De Cristo, Ferreira, Marília, Infantes Ormad, Marina, Kouliou, Marina Nektaria, Ransome, Marina, Vicario Bravo, Marina, Cuesta Argos, Mario, Faletar, Mario, Giuffrida, Mario, Lainez Escribano, Mario, Pacilli, Mario, Pannullo, Mario, Rodriguez-Lopez, Mario, Trejo-Avila, Mario, Merrakos, Marios, Tello Jimenez, Marisol, Kalisvaart, Marit, Quaunine, Marium, Perera, Mariyan, Harris, Mark, Youssef, Mark Melad Thabet, Peter, Mark, Philipp, Mark, Portelli, Mark, Jesudason, Mark Ranjan, Sammut, Mark, Tomlinson, Mark, Zammit Vincenti, Mark, Despotidis, Markos, Albertsmeier, Markus, Quante, Markus, Löffler, Markus W., Gurung, Markush, Gumsheimer, Marlena, Benamrouche, Maroua, Chaccour, Maroun, Ahmed, Marriam, Farooqui, Marryam Riaz, Angelini, Marta, Ortega Escudero, Marta, Martin Gimenez, Marta Pilar, Reia, Marta, Scricciolo, Marta, Caramantin Obando, Martha Maria, Gosselink, Martijn, Bertrand, Martin, Dum, Martin, Kajic, Martin, Karamanliev, Martin, Kyereh, Martin, Lucchini, Martin, Schön, Martin, Morna, Martin Tangnaa, Binda, Martina, Ceolin, Martina, Martorana, Martina, Zambon, Martina, Shams, Marvi, Alansary, Marwa, Alnuwayli, Marwa, Khalifa, Marwa, Bahnacy, Marwan, Iqreewi, Marway, Nnabagulanyi, Mary, Saleem, Marya, Alhimyar, Maryam, Kamal, Maryam, Masood, Maryam, Razaq, Maryam, Siddique, Maryam, Lazo Ramírez, Maryzela, Edeeb, Masaoud, Solkar, Maseera, Adetoyi, Mashood, Adeniyi, Caccetta, Massimiliano, Casati, Massimiliano, Veroux, Massimiliano, Dugo, Massimo, Bevanda, Mateo, Santillan, Mateo, Mietła, Mateusz, Pryt, Mateusz, Muir, Mathew, Bei, Matilda, McGuinness, Matt, Aulicino, Matteo, Castrovillari, Matteo, Filardo, Matteo, Palmeri, Matteo, Pisano, Matteo, Rottoli, Matteo, Gjoka, Mattheus, Binks, Matthew, Corcos, Matthew, Kwon, Matthew, Maybury, Matthew, Sammut, Matthew, Tutton, Matthew, Watson, Matthew, Biebl, Matthias, Janda, Matthias, Maak, Matthias, Wichmann, Matthias, Berselli, Mattia, Gritti, Mattia, Molteni, Mattia, Pacilli, Maurizio, Favoriti, Mauro, Garino, Mauro, Podda, Mauro, Santarelli, Mauro, Alfaid, Mawada, Albert, Mawadri Jimmy Isaac, Oyortey, Mawuenyo Attawa, Enßlin, Max, Berlet, Maximilian, Brunner, Maximilian, Kießler, Maximilian, Scheiterle, Maximilian, Sohn, Maximilian, Busch, Maximiliane, Perkins, Maya, Sabboh, Maya, Badkur, Mayank, Okudero, Mayowa, Mohamedshafee, Maysoon, Al-Juaifari, Maytham Aqeel, Elesseily, Mazen, Mohammad, Mazen, Nikberg, Maziar, Jean Claude, Mbonicura, Şermet, Medeni, Chisthi, Meer, Luthra, Meera, Sulciner, Megan, Kaple, Meghali, Bhat, Meghana, Koç, Mehmet Ali, Avci, Mehmet Alperen, Kizilkaya, Mehmet Celal, Kara, Mehmet Emin, Ozcelik, Mehmet Faik, Ozsoy, Mehmet Sait, Zaigham, Mehreen, Mesfin, Mekdelawit, Kalender, Mekselina, Mellado Tellez, Mel Paul, González De Miguel, Melania, Farrugia, Melanie, Theodoridou, Melanie, Barcelona, Melden Darrell, Aktas, Melik Kagan, Fernández Zurita, Melissa Andrea, Bautista, Melissa, Park, Melissa, Rodríguez-Ordoñez, Melissa-Zohemia, Yashar, Meltem, Worku, Mengistu, Al-Fraijat, Meran, Estaire Gómez, Mercedes, Shoshkova, Meri Danailova, Kruščica, Merima, Tanal, Mert, Çuhadar, Merve, Tokocin, Merve, Agyapong, Meshach Manu, Erkaya, Metincan, Okechukwu, Mgbako, Adinku, Michael, Bickford, Michael, Ediale, Michael, Issa, Michael, Konstantinidis, Michael K., Lie, Michael, M. Nathan, Michael, Maclean, Michael, Nortey, Michael, Pellen, Michael, Pham, Michael, Pitiakoudis, Michael, Singh, Michael Prodip, Spartalis, Michael, Van Der Colf, Michael, Wilson, Michael, Billis, Michail, Karanikas, Michail, Papamichail, Michail, Vailas, Michail, Kisielewski, Michał, Kusiński, Michał, Nycz, Michał, Święch, Michał, Fagbayimu, Micheal, Adamina, Michel, Fiogbe, Michel, Prudhomme, Michel, Angelucci, Michela, Campanelli, Michela, Cricrì, Michele, Grande, Michele, Manigrasso, Michele, Scopelliti, Michele, George, Michelle, Mozel, Michelle, Galasyuk, Mick, Chevallay, Mickael, Giuliano, Micol, Dobón Rascón, Miguel Ángel, Fernandez Romero, Miguel Angel, García Ureña, Miguel Ángel, Zaragoza Mendieta, Miguel Ángel, Bejarano Serrano, Miguel, Brito, Miguel, Calderon, Miguel, Jurado Román, Miguel, Palas, Miguel, Li Valencia, Miguel Roberto, Sebastián-Mendoza, Miguel-Julián, Muresan, Mihai-Stefan, Slavchev, Mihail, Agapov, Mikhail, Milentijević, Milica, Catterall, Millie, Stjepanovic, Milos, Doss, Mina, Natey, Mina, Aikins, Minas, Mattis, Minca, Ekanayake, Minoli Tharushika, Tora, Mir Mehrab Sharmin, Alsharayri, Mira, Shalaby, Mira, Boras, Miran, Riba Martínez, Mireia, Mogiatti, Mirella, Salibašić, Mirhan, Biancu, Miriam, Cappiello, Miriam, Koschke, Miriam Luise, Sadek, Mirna, Szura, Miroslaw, Horga, Miruna, Dason, Mishael, Tayyab, Mishal, Imirski, Mitko, Pejović, Mladen, Tabaza, Mo'Ath, Alneasan, Moaaz, Shalkamy, Moamen, Issa, Moammad Issa, Erfan, Moatasem, Ewedah, Moataz, Srour, Moayad, Beletachew, Moges, Abbas, Mohamad, Farho, Mohamad Ali, Marawy, Mohamad Kher, Klib, Mohamad, Morjan, Mohamad, Sawas, Mohamad Nabhan, Elghriani, Mohamed Abdelbaset Masoud, Abdelmaboud, Mohamed, Abdelmaksoud, Mohamed, Abdullahi, Mohamed, Abo Abdo, Mohamed, Ahmed, Mohamed, Ahmoud, Mohamed, Al Sayed, Mohamed, Suliman, Mohamed Almouafaq, Alsori, Mohamed, Altajouri, Mohamed, Assalhi, Mohamed, Berrakkouch, Mohamed, Elnour, Mohamed, Abdelsalam, Mohamed Elsayed Elaraby Abdelrahim, Elsayed Metwally, Mohamed, Hajalamin, Mohamed, Kamal Matter, Mohamed, Khaled, Mohamed, Kouta, Mohamed, Masoud, Mohamed, Almihashhish, Mohamed Miftah, Mokhtar, Mohamed, Mostafa, Mohamed, Yassin, Mohamed Musa, Bouhafs, Mohamed Nedjmeddine, Herdan, Mohamed Omar, Omer, Mohamed, Osman, Mohamed, Zaazou, Mohamed, Zahed Abdalla, Mohamed, Melouane, Mohamed-Sami, Abed, Mohammad, Sawaftah, Mohammad Ahmad Mohammad, Al-Masri, Mohammad, Al-Qannas, Mohammad, Ali-Hassanzadeh, Mohammad, Yunus, Mohammad Alif, Aloulou, Mohammad, Alrantisi, Mohammad, Araydah, Mohammad, Bani Hani, Mohammad, Barakat, Mohammad, Durrani, Mohammad, Khan, Mohammad Faisal, Dwikat, Mohammad Fuad, Hasan, Mohammad, Nabhan, Mohammad Hassan, Hijazi, Mohammad, Abu Albahrain, Mohammad Karam, Barakat, Mohammad Mounzer, Mubarak, Mohammad, Omar, Mohammad, Pourfridoni, Mohammad, Mslmani, Mohammad Rabee, Salah, Mohammad, Tanashat, Mohammad, Yahmad, Mohammad, Elmujtaba, Mohammed, Abd Al-Fattah, Mohammed, Abdelkabir, Mohammed, Abosedra, Mohammed, Sarker, Mohammed Abu Kawsar, Abudabbous, Mohammed, Abuwarda, Mohammed, Elgak, Mohammed Ahmed, Al Hinai, Mohammed, Al Zebda, Mohammed, Al-Shehari, Mohammed, Alharthi, Mohammed, Ali, Mohammed, Ismael Alamin, Mohammed Ali, Alqadasi, Mohammed, Alshanwani, Mohammed, Alshehri, Mohammed, Asaad, Mohammed, Bashir, Mohammed, Bohlala, Mohammed, Meghaizerou, Mohammed El Amine, Albanna, Mohammed Emad Hashem, Ghunaim, Mohammed, Goga, Mohammed, Hajhamad, Mohammed, Hamada Takrouney, Mohammed, Hammoda, Mohammed, Hamoud Almahly, Mohammed, Muragi, Mohammed, Mohammed, Mohammed Mustafa Hassan, Obaid, Mohammed, Omar, Mohammed, Said, Mohammed, Salah, Mohammed, Saleh Khatab, Mohammed, Aliyu, Mohammed Salele, Shakhshir, Mohammed, Sheriff, Mohammed, Tageldin, Mohammed, Abdelfattah, Mohanad, Daher, Mohanad, Lotfy, Mohanad, Alqedrh, Mohannad, Nasani, Mohannad, Mohd Shah, Mohd Shahrulsalam, Madany, Mohie El-Din Mostafa, Mobolaji-Ojibara, Mojisola, Nkogatse, Moleseng, Alazabi, Mona, Gupta, Money, Bogdan, Monica, Guerrero, Monica, Noguez Castillo, Monica, Gureh, Monika, Kacem, Montasser Jamaleddine, Tarar, Moosa Feroze, Seto, Morel, Steinruecke, Moritz, Edena, Morrison, Abdulsalam, Moruf, Abdelhadi Suliman Adam, Mosab, Saleh, Mosab, Anati, Mosaikah, Dokurugu, Moses Abdulai, Agunloye, Moses, Ibadin, Moses, Momoh, Moses, Abdelkarim, Mostafa, Kamar, Mostafa, Kotb, Mostafa, Mahran, Mostafa, Mohamad Amin, Mostafa, Shalaby, Mostafa, Waseem, Mostafa, Almaletti, Motasem, Saifi, Motaz, Tsuruta, Motohisa, Agbadebo, Mouhamed, Arnaout, Moumen, Ojo, Moyosoluwa, Sharma, Mrthyunjayani, Azzuz, Muad Mohamed Ramadan, Haj Hussein, Mudar, Ameen, Muftiat Omolola, Nkoronko, Mugisha, Fitri, Muhamad, Abdullah, Muhammad, Bashir, Muhammad Ahmad, Sadiq, Muhammad Ahmad, Ahmed, Muhammad, Ali, Muhammad, Al-Yusuf, Muhammad Ali, Haider, Muhammad Aliyan, Alshaar, Muhammad, Mirza, Muhammad Bilal, Che Yaacob, Muhammad, Daniyan, Muhammad, Elzayat, Muhammad, Butt, Muhammad Faizan, Sadiq, Muhammad Hamza, Chishti, Muhammad Haris, Ismail, Muhammad Izzat Shufphi, Kashif, Muhammad, Khalid, Muhammad, Mansoor Iqbal, Muhammad, Bin Khalid, Muhammad Moaz, Rafique, Muhammad Nouman, Raheem, Muhammad, Khalid, Muhammad Saud, Usama, Muhammad, Usman Malik, Muhammad, Saqib, Muhammad Waleed, Elhadi, Muhammed, Ateş, Muhammed Ikbal, Demirpolat, Muhammed Taha, Ergenç, Muhammer, Bello, Muideen, Kulimbet, Mukhtar, Nyirenda, Mulinda, Taeme, Mulugeta, Denini, Muna, Aziz, Munazzah, Yahaya, Mundashiru, Eugene, Muneza, Amadu, Munira, Chauhan, Munish, Acar, Murat, Teressa, Murti, Dauphin, Muryango, Arafat, Musa, Althomali, Musab, Rayzah, Musaed, Husain, Musharraf, Tolani, Musliu Adetola, Abu Jayyab, Mustafa, Al-Attraqchi, Mustafa, Kara, Mustafa Alper, Seker, Mustafa Ege, Gün, Mustafa, Hamed, Mustafa, Mehanny, Mustafa, Oncel, Mustafa, Sabri Massadi, Mustafa, Uyanik, Mustafa Safa, Uzunoglu, Mustafa Yener, Abdullahi, Mustapha, Saidani, Mustapha, Nofal, Mutaz, San, Myat, Ishak, Myrna, Keramida, Myrto D., Nik Burhanuddin, N.M. Syahrin, Talat, Nabila, Shehata, Nada, Alasbahi, Nadeen, Marcos, Nádia, Al Amri, Nadiah, Absy, Nadine, Parker, Naeelah, Lindi, Naeimah, Omer, Nafisa, Papadogianni, Nafsika, Rawal, Nagendra, Ismaiel, Nahar, Ben Hasan, Najat, Albahloul, Najla, Gokhare Viswanath, Nakul, Srinivas, Namitha, Christian, Nana Ama, Obuobi, Nana Kwame Asare, Beharry, Naomi, Yousefzadeh Kandevani, Naser, Alnamari, Nashwan, Oyelowo, Nasir, Oloko, Nasirudeen, Alzerwi, Nasser, Mosbah, Nasser, Shulman, Nastassia, Andrade, Natacha, Boumas, Natacha, Cobeño Tamayo, Natalia, Barrera Lopez, Natalia Guadalupe, Palamara, Natalia, Blencowe, Natalie, Marzouqa, Natalie, Blencowe, Natalie S, Salgadoe, Natalie, Techapongsatorn, Nathakorn, Paez, Nathaly, Ekwo, Nathan, Saini, Navdeep, Malik, Naveed Akhtar, Sharma, Naveen, Kumar, Navin, Chaudhry, Navneet Kumar, Karimbocus, Nawaaz, Rasool, Nazeerah, Lodhi, Nazia, Kavak, Nazli, Ildephonse, Ndayiragije, Diomede, Nduwimana, Bayleyegn, Nebiyou S., S.Bayleyegn, Nebiyou, Jović, Nediljko, Mosleh, Neebal, Aruldas, Neerav, Kapur, Neeti, Paul Sigamony, Negine Paul, Karthikeyan, Neha, Tabatabaian, Nelia, Affram, Nelson, Agboadoh, Nelson, Tran, Nelson, Lalovic, Nenad, Agugua-Obianyo, Nene, Kullab, Nermen, Lahmer, Nesrin, Raiq, Neven, Soldo, Neven, Spiteri, Neville, Chen, Nevin, Al Rabadi, Nezar, Christian, Ngarambe, Cabrel, Ngongang Ngansop, Leonelle Lore, Nguefack Noudem, Furbetta, Niccolò, Ensor, Nicholas, Tsantikos, Nick, Seeger, Nico, Cillara, Nicola, Eardley, Nicola, Petrarota, Nicola, Tartaglia, Nicola, Feijoo, Nicolas, Finocchiaro, Nicole, Koter, Nicole, De Santis, Nicolò, Fabbri, Nicolò, Schiavon, Nicolò, Tamini, Nicolò, Sharma, Nidhi, Sánchez Fuentes, Nieves, Solomon, Nigus, Bugdayci, Nihat, Lekiashvili, Nika, Gupta, Nikhil, Narain, Nikhil, Uttam, Nikita, Kłos, Nikola, Ververidis, Nikolaos Adrianos, Arkadopoulos, Nikolaos, Dimitrokallis, Nikolaos, Garmpis, Nikolaos, Gouvas, Nikolaos, Kalampokis, Nikolaos, Kopanakis, Nikolaos, Kydonakis, Nikolaos, Machairas, Nikolaos, Memos, Nikolaos, Michalopoulos, Nikolaos, Mathioudakis, Nikolaos Nestor, Roukounakis, Nikolaos, Stamos, Nikolaos, Tasis, Nikolaos, Tsakiridis, Nikolaos, Vlachakos, Nikolaos, Zampitis, Nikolaos, Kouzakos, Nikolas, Börner, Nikolaus, Dimitriou, Nikoletta, Dafnios, Nikos, Banerjee, Niladri, Klammer, Nils, Maharjan, Nima, Rabai, Nimah, Oscar, Nimpaye, Harrison, Nina, Kheyrbek, Nina, Kansakar, Nirajan, Bhat, Nisar, Krishnappa, Nischal, Pahuja, Nisha, Paul Ambrose, Nitin, Renovat, Niyongabo, Musawa, Nizar, Nwanne, Njideka, Steve, Nkurunziza, Chidumije, Nnaemeka, Nwafulume, Nnaemeka, Celestine, Nnamani, Duru, Nnamdi, López Bernal, Noelia Esthela, Laquatra, Noemi, Pasqua, Noemi, Awwad, Noor Al-Deen, Ali, Nora, Hielscher, Nora, Trabulsi, Nora, Hüser, Norbert, Muñoz Montes, Norberto, Eshak, Norma-Sol, Rajab, Nosaiba, Lahnaoui, Nouhaila, Ouachou, Nouhaila, Ali, Nour, Dadoush, Nour, Fazili, Noureen, Theophile, Ntahompagaze, Ntanzi, Ntuthuko, Bibila, Nubia Samuel, Alwaer, Nuhay, Naabo, Nuhu, Jiagge, Nuna, Freitas Oliveira, Nuno Miguel, Pratas, Nuno, Morricone, Nunzia, Franco, Nunzio Francesco, Binti Yusri, Nur Aima, Ramli, Nur Natasya, Abd Ghani, Nur Suriyana, Umar, Nura, Aly, Nuran Khaled, Lakhanov, Nurgali, Al-Hroub, Nurhan, Kiziltoprak, Nurhilal, Chavarrias, Nuria, Maulenov, Nurlan, Akinbami, Nurudeen, Abdulraheem, Nurudeen Toyin, Karunaratne, Nuwanthika, Jeannette, Nyiransabiyera, Altobaishat, Obieda, Egwuonwu, Ochonma Amobi, Enciu, Octavian, Cohen-Arazi, Oded, Pheiffer, Odette, Okoye, Odili Aloysius, Omoike, Ofure, čančar, Ognjen, Ekwunife, Okechukwu Hyginus, Emuze, Okundayo, Eljizoly, Ola Abdallah, Al Hamdani, Ola, Emadeldeen, Ola, Morgan, Ola, Olajumoke, Oladapo, Popoola, Olakunle, Ajiboye, Olalekan, Olasehinde, Olalekan, Jolayemi, Olamide, Babatunde, Olanrewaju, Balogun, Olanrewaju, Olajide, Olawumi, Lisin, Oleg, Bellou, Olga, Jurić, Oliver, Ladlow, Oliver, Whitehurst, Oliver, Camilleri, Olivia, Montaño Angeles, Olivia, Pryer, Olivia, Ray, Olivia, Gabom, Olivier, Ndizeye, Olivier, Ojewuyi, Olufemi, Oluyemi, Olukayode, Elebute, Olumide, Ogunsua, Oluseyi, Fasiku, Olushola Kayode, Fasoro, Olusola, Fatudimu, Oluwafemi, Osunlusi, Oluwafemi, Owolanke, Oluwagbenga, Oso, Oluwarotimi, Alaba, Oluwaseun, Ojo, Oluwaseun, Oluseye, Oluwaseun, Oyinloye, Oluwaseun, Al Alyani, Omaima, Okrah, Omane, Agha, Omar, Al-Fahel, Omar, Almomani, Omar, Alruwaili, Omar, Ibarra, Omar, Ibrahim, Omar, Khalil, Omar, Kouli, Omar, Lima Azurdia, Omar, Mansour, Omar, Mohamed Mokbel, Omar, Omar, Omar, Bedak, Omer, Ozkan, Omer Faruk, Yalkın, Omer, Mohamed, Omnia, Ayandipo, Omobolaji, Faboya, Omolara, Williams, Omolara Modupe, Irowa, Omorodion, Attawodi, Onuche, Salako, Opeyemi, Ioannidis, Orestis, Agcaoglu, Orhan, Martin Sole, Oriol, Webster, Orla, Abouhiekal, Osama, Al Shaqran, Osama, Bahsas-Zaky, Osama, Nubi, Osama Gamal, Hany, Osama, Matar, Osama, Mahafdah, Osama R., Sarhan, Osama, Osagie, Osasumwen, Soublett Rivas, Óscar Alexander, Gülcicek, Osman Bilgin, Cuenca Torres, Osmar Manuel, Carpineto Samorani, Osvaldo, Arsalan, Othman, Coyoy-Gaitán, Otto, Nouhail, Oumaima, Boujidi, Oumama, Dicko, Ousmane A A, Ahmad, Owais, Christianah, Oyegbola, Küpçüoğlu, Özge, Zanbak Mutlu, Özgecan Pırıl, Chadha, P, Prabhu, P Santosh, Carmignani, Pablo, Arteaga Asensio, Pablo Cesar, Del Val Ruiz, Pablo, Royo Dachary, Pablo, Sancho Pardo, Pablo, Vásquez, Pablo, Sukhvibul, Pakkapol, Assouto, Pamphile, Evangelou, Panagiota, Dorovinis, Panagiotis, Kapsampelis, Panagiotis, Kokoropoulos, Panagiotis, Kostoglou, Panagiotis, Manikis, Panagiotis, Sakarellos, Panagiotis, Lykoudis, Panagis, Kumar, Pankaj, Patel, Panna, Paraskeva, Panoraia, Vassiliu, Panteleimon, Antonakis, Pantelis, De Nardi, Paola, Marongiu, Paola, Kamenova, Paolina, Venturelli, Paolina, Belotti, Paolo, Ubiali, Paolo, Grivas, Paraskevas, Stamopoulos, Paraskevas, Chatzikomnitsa, Paraskevi, Trakosari, Paraskevi, Tekam Wadje, Parfait Stéphane, Manjunath, Parikshith, Gupta, Pariza, Dhamija, Parth, Haque, Parvez, Haque, Parvez David, Haque, Parwez Waseemul, Nze Obiang, Pascal Christian, Probst, Pascal, Chiacchio, Pasquale, Cianci, Pasquale, Favoriti, Pasqualino, Koggoh, Patience, Bernardo, Patrícia, Omwansa, Patricia, Serrano Méndez, Patricia, Owens, Patrick, Tang, Patrick, Walker, Patrick, Chimezie Andrew, Paul, Trinity, Paul, Wilson, Paul, George, Paul Yohan, Artigot, Paula, Devlin, Paula, Vladova, Paulina, Cabrera Rivera, Paulo Andrés, Arunachalam, Pavai, Glushkov, Pavel, Levíček, Pavel, Lal, Pawanindra, Panahi, Pedram, David Santos, Pedro, Laranjo, Pedro, Palazon Bellver, Pedro, Rego Ponte, Pedro, Salas Núñez, Pedro, Sornoza, Pedro, Chloropoulou, Pelagia, Correia, Penélope, Limani, Perparim, Agbonrofo, Peter, Boateng, Peter Agyekum, Elemile, Peter, Francúz, Peter, Riedl, Peter, Tschann, Peter, Yuide, Peter, Hudáč, Petr, Ostruszka, Petr, Zimmermann, Petra, Nambala, Petrus, Shimbulu, Petrus, Thomas, Phebey A, Kumassah, Philemon, Alexander, Philip, Mensah, Philip, Taah-Amoako, Philip, Horvath, Philipp, Garcia-Dubus, Philippe, Holt, Phillip, Lapolla, Pierfrancesco, Cicerchia, Pierfranco Maria, Palumbo, Piergaspare, Anoldo, Pietro, Calò, Pietro Giorgio, Grondona, Pietro, Masseria, Pietro, Riva, Pietro, Milewski, Piotr Jan, Kowalewski, Piotr, Kasetsermwiriya, Pohpdham, Patel, Poojan, Leungon, Poramet, Kaur, Prabhjot, Arya, Prafull Kumar, Shivashankar, Pranav, Kothari, Prashant, Dummala, Prashanth, Shukla, Prateek, John, Pravin, Adebayo, Precious, Andrejevic, Predrag, Thambi, Prem, Anandan, Premkumar, Idjerhe, Prince, Boateng, Prince Kwame, Ntem, Prince, Waghchoure, Prince, Yeboah Owusu, Prince, Moodley, Priyanka, Suresh, Priyanka, Kanavidis, Prodromos, Odigie, Vincent, Christodoulou, Prokopis, Nashidengo, Pueya Rashid, Patel, Puja, Dolatzay, Qayom Khan, Mashlah, Qusai, Sabbah, Qutaiba, Sethi, R, Robitsek, R. Jonathan, Jubran, Ra'Ed, Raheem Attallah Al-obaidy, Raad, Michael, Rabha, Abela, Rachel, Colbran, Rachel, Geow, Rachel, Titcombe, Rachel, Soglonou, Rachelle, Ait Ben Addi, Rachid, Jayakrishnan, Radhakrishnan, Acharya, Radhika, Salim, Radhwan, Guzmán Lambert, Radisnay, Donchev, Radoslav, Drasovean, Radu, Andreou, Rafael, Perez-Soto, Rafael Humberto, Santana Ortiz, Rafael, Villalobos Mori, Rafael, Sokratous, Rafailia, Smolinski Kurek, Rafal Ludwik, Solecki, Rafal, Basile, Raffaele, Abd Elkareem, Raghad, Yousef Yassin, Raghad, Faisal, Raghdah, Abd Alkareem, Rahaf, Hegy, Rahma, Jaba'Teh, Rahmah, Sharma, Rahul Deo, Gupta, Rahul, Saxena, Rahul, Sinha, Rahul, Varshney, Rahul, Ripoll I Palmés, Raimon, Lunevicius, Raimundas, Raghunath, Rajat, Redkar, Rajeev, Sharma, Rajeev, Philip Sridhar, Rajeevan, Krishna Raj, Rajesh, Nathani, Rajesh, Kottayasamy Seenivasagam, Rajkumar, Ahmed, Rakesh, Handa, Rakesh, Vakil, Rakesh, Armah, Ralph, Attaf, Ram, Elazary, Ram, Alkhatib, Rama, Alzu'Bi, Rama, Raddad, Rama, Kaur, Ramanjot, Kaur, Ramanpreet, Nataraja, Ramesh, Hussam Yacoub Hattar, Ramez, Ben Hmida, Rami, Chaudhary, Ramkaran, Ramirez Calas, Ramon Andres, Soliva Domínguez, Ramón, Ghaleb, Ramzi, Batir, Rana, Haddad, Rana, Sugair, Rana, Suleiman, Rand, Perera, Ranga, Altayargh, Rania, Joumaa, Ranim, Ellawala, Ranjith, Elaifia, Rany, Eloka, Raphael, Hernandez Rodriguez, Raquel Angelica, Diaz, Raquel, Lalanda, Raquel, Rodríguez-Uria, Raquel, Olatunji, Rasheed, Wani, Rauf, Díaz Pedrero, Raúl, Ubiñas, Raul, Lertnamvongwan, Raunika, Hiary, Rawan, Almahadin, Rawan Khalid Za'al, Radwan, Rawan, Issa, Rawand, Dar, Rayees Ahmad, Nyirenda, Raymond, Eghonghon, Raymond Atah, Oppong, Raymond, Govindaraju, Rayshini, Kalouk, Razan, Abad, Rebeca, Akankoatuesi Apatewen, Rebecca, Bradley, Rebecca, Enejo, Rebecca Eboshogwe, Hauwa Sani, Rebecca, Jurdon, Rebecca, Sönmez, Recep Erçin, Belouz, Reda, Abhinaya, Reddy, Abu Salah, Reem, Alatawi, Reem, Alqahtani, Reem, Sayad, Reem, Adel Diab, Rehab, Függer, Reinhold, Madi, Reman, Pajtak, Renata, Barradas, Renato, Díaz-Ruiz, Renato, Patrone, Renato, Palacios Huatuco, René M., Casma Bustamante, Renzo, Ranadive, Reuben Rajappa, Askari, Reza, Sulce, Rezart, Liang, Rhea, Tummon, Rhea, Roberts, Rhianna, Mcclen, Rhys, Duvenage, Riaan, Kattini, Ribal, Alvarado Hurtado, Ricardo, Tenfen Carneiro, Ricardo Augusto, Castro Lara, Ricardo Jesús, Silva Borges, Ricardo, Souto, Ricardo, Vaz Pereira, Ricardo, Barone, Riccardo, Fratarcangeli, Riccardo, Guercio, Riccardo, Magarini, Riccardo, Malatesti, Riccardo, Tripathi, Richa, Crawford, Richard, Kpangkpari, Richard, Marlin, Richard, McGee, Richard, Nesco, Richard, Spence, Richard, Akpaka, Richfield, Alinde, Rigobert, Khalid, Rija, Sato, Rikiya, Kitamura, Riley, Baldan, Rino, Agyei Boakye, Rita, Branquinho, Rita, Hleyhel, Rita, Miranda Pera, Rita, Pinheiro Duque, Rita, Ribeiro Dias, Rita, Bhatia, Riya, Rabah, Rnad, Damseh, Ro'Ya, Alzughayyar, Roa, Daradkeh, Roa'A, Bassam, Roaa, Refaie, Roaa, Bethune, Rob, Elshennawy, Roba, Cachia, Robert, Franz, Robert, Grützmann, Robert, Kibuuka, Robert, Laskowski, Robert, Mazurkiewicz, Robert, Munyaneza, Robert, Parker, Robert, Sagoe, Robert, Sucher, Robert, Granata, Roberta, Ruccella, Roberta, Tutino, Roberta, Badra, Roberto, Mares País, Roberto, Sampietro, Roberto, Scola, Roberto, Mackay, Robyn, Tumolo, Rocco, Figueroa, Rodrigo, Doamba, Rodrigue, Habib, Rohan, Gujjuri, Rohan R, Anjum T Siddeek, Rohik, Mittal, Rohin, Kumar, Rohit, Goudou, Roland, Rüdrich, Roland, Senin, Roman, Moukarzel, Romika, Ferlini, Romina Lorena, Ribeiro, Rómulo, Schmidt-Branden, Romy, Zerna Encalada, Ronald, Ferreira Acosta, Rosa, Lopatriello, Rosanna, Perez, Rosario, Hall, Rosie, Alloni, Rossana, Arena, Rossella, Gioco, Rossella, Polo, Roxy, Shen, Ru, Doherty, Ruairi, Rivas, Ruben, Oppong-Amoah, Ruby, Ooi, Rucira, Radojković, Rudolf, Herrera, Rudy, Bernardino, Rui, Ediru, Rukevwe, Al Shehhi, Ruqaiya, Masri, Ruqaya, Hodgson, Russell, Azimov, Rustam, Martínez Díaz, Rut, Santos Pereira, Rute, Naidoo, Ruvashni, Noor, Ruzaimie, Campbell, Ryan, Khalil, Ryta, Chigblo, S. 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Sharitha, Laura, Sharon, Shanker, Shashwat, Ababneh, Shatha, Gilbert, Shaun, Kenworthy, Shaunna, Ng, Shawn Hong Ming, Mackenzie, Shawn, Salindera, Shehnarz, Khattak, Shehrbano, Loke, Sheih Nee, Manzoor, Sheikh Viqar, Alwardi, Sheikha, Allam, Shereen, Tawfik, Sherifa, Francis, Shikha, Cai, Shirley, Dindyal, Shiva, Pandya, Shivangi, Chopra, Shreya, Ingley, Shreya, Kulkarni, Shrirang, Kosna, Shuba, Nayak, Shubhalaxmi, Ahuja, Shubham, Hariharan, Shubhang, Karuppusamy Krishnasamy, Shyam, Khare, Siddhant, Handa, Siddhartha, Amin Omar Alsiddig, Siddig, Alqurashi, Siddiga, Al-Tahayneh, Sief-Addeen, Sibiya, Silindokuhle, Perretta, Silvana, Ibarra Camargo, Silvia Alejandra, Montisci, Silvia, Mungo, Silvia, Puddu, Silvia, Severi, Silvia, Agudelo Mendoza, Silvia Valentina, Makkai-Popa, Silviu Tiberiu, Boyes, Simon, Monkhouse, Simon, Stock, simon, Alberti, Simona, Meneghini, Simona, Giudici, Simone, Guadagni, Simone, Birolo, Simone Lorenzo, Novello, Simone, Oliveira, Simone, Gumede, Simphiwe, Dhole, Simran, Budhwani, Simran Saleem, Ramjit, Sinead, Yumurtacilar, Sinem, Mahendra, Sirigi Naga, Abeykoon, Sithira, Moh Pauzi, Siti Farhan, Rajendra, Sittampalam, Sundararajan, Siva, Gananadha, Sivakumar, Kamarajah, Sivesh K, Marawu, Siyasanga, Basu, Sk, Hassan, Sleman, Reddy, Snigdha Mettu, Anaya Sanchez, Sofia, Gaspar Reis, Sofia, Gomez, Sofía, Gamba, Sofia Lucia, Pimentel Morais, Sofia, Ashry, Soha, Abdullateef, Sohaila, Bandyopadhyay, Soham, Samadi, Soheil, Pathan, Sohilkhan R., Lakew, Solomon, Basu, Somprakas, Ohri, Sonali, Alonso Marcos, Sonia, Amoza Pais, Sonia, Fortuna Martins, Sónia, Gill, Sonia, Matthiess, Sonia, Sabbatini, Sonia, Soto Schütte, Sonia, Engel, Sophie, Eam, Sothseyhakmonique, Botaitis, Sotirios, Lawani, Souliath, Jamil, Soumaya, Kondpan, Sourav, Oum, Sovannarith, Govender, Sovishnee, Christodoulou, Spyridon, Davakis, Spyridon, Vernadakis, Spyridon, Gkogkos, Spyros, Gobishangar, Sreekanthan, Suresh, Sreelakshmi, Vembar, Sridhar, M, Srikanth, Abdelrasoul Elnour Ismail, Srraa, Zourntou, Stamatina-Emmanouela, Nwabuoku, Stanley Emeka, Ideh, Stanley, Charitonos, Stavria, Liapis, Stavros Chrysovalantis, Faber, Stefan, Piccioni, Stefania Angela, Romano, Stefania, Silvestre, Stefania, Jarmusch, Stefanie, Soelling, Stefanie, Cardelli, Stefano, Chaifouroosh Mamagany, Stefano, Corso, Stefano, Basso, Stefano Maria Massimiliano, Megna, Stefano, Bitsianis, Stefanos, Tsatsos, Stefanos, Morales, Steffanía, Gerdes, Stephan, Göller, Stephanie, Hanna, Stephanie, Tabiri, Stephen, Agana, Stephen, Theivendran, Stephen Arthur, Kache, Stephen, Knight, Stephen R, Smith, Stephen, Stonelake, Stephen, Wrenn, Stephen, Gopaul, Steven, Vederaki, Styliani, Kapiris, Stylianos, Kykalos, Stylianos, Hlaing, Su Su, Chia, Su Yin Denise, Abu Khousa, Suad, M. Udwan, Suad, Raul, Subrat, Chase, Suchita, Nair, Sudharrshan, Joseph, Sudhir, Singh, Sudhir Kumar, Singh, Sudhir, Timmalah, Suhaylah, Alsuwiyah, Suhir, Thalgaspitiya, Sujeewa Priyantha Bandara, Sellahewa, Sujeewa, Neogi, Sujoy, Burger, Sule, Polat, Süleyman, Alkadi, Sulman, Asiri, Sultan, Otho, Sumaira, Mewa Kinoo, Suman, Ebrahim, Sumayyah, Tontus, Sumeyya, Midya, Sumit, Thuraisamy Sarma, Sundaramoorthy Iyer, Payyanur Thotan, Sundeep, Kumar Venkatappa, Sunil, Techapongsatorn, Suphakarn, Kaur, Supreet, Jp, Supritha, Tan, Suqi, Djote, Surafel Mulatu, Surendran, Suraj, Singh, Surendra, Chilaka, Suresh, Lee, Susan, Henriques, Susana, Giridaran, Suseendirarajah, Achugatla, Sushma, Kumar, Suvam, Brincat, Svetlana, Deshpande, Swati, Batista, Sylvia, Akharaekpanya, Tachporn, Moges, Tadesse Girma, Türkmen, Taha Berkay, Alhaj Hasan, Taima, Alshawabkeh, Taima', Majed, Taima', Lawal, Taiwo Akeem, Ibiyeye, Taiye Taibat, Rashid, Tajamul, Košir Božič, Tajda, Mohammed, Tajudeen, Khewater, Talal, Abelman, Talia, Al Barhi, Tamadher, Mogne, Tamiris, Salazar-Lorenzana, Tania Abril, Akter, Tania, Gómez Sanz, Tania, Motiwala, Tanmay, Valizadeh Elizeh, Tanya, Almahdi, Tanzeel, Albushary, Tanzel Alrahman, Abdulrahman, Taofeeq, Finlay, Tara, Chouari, Tarak, Awad, Tarek, Sabra, Tarek, M. Abubasheer, Tareq, Alhusban, Tariq, Yılmaz, Tarık Emre, Aloqaili, Tasneem, Aldirawi, Tayef, Karahasanoğlu, Tayfun, Gülşen, Taygun, Jemal, Tebarek, Nadeem, Tehmina, Singh, Tejinder Paul, Alinger, Temsula, Longkumer, Temsutoshi, Lo, Terence, Gimenez Maurel, Teresa, Uprak, Tevfik Kıvılcım, Petropoulou, Thalia, Rawther, Thampi, Techapongsatorn, Thawin, Manickam, Thendral, Padioti, Theodora, Kozonis, Theodoros, Sidiropoulos, Theodoros, Tsirlis, Theodoros, Theodosopoulos, Theodosios, Hessou, Thierry Kinnongni, Uiyapat, Thitapon, Agyen, Thomas, Harris, Thomas, Hugh, Thomas J, Jorgensen, Thomas W., Theivendrampillai, Thrshegan, Pham, Thuy Vy, Branco, Tiago, Nagwamutse, Tijjani Nasiru, Tony V, Tina, Devabalan Koil, Titus, Pilia, Tiziana, Abdulmola, Tmador Mahmed Ali, Oyeyemi, Tobiloba, Kebede, Tolera, Ibarra-Hurtado, Tomás Ramón, Reichelt, Tomas, Gach, Tomasz, Stefura, Tomasz, Wojewoda, Tomasz, Soric, Tomislav, Risteski, Toni, Tridip, Tridip Dutta Baruah, Yotsov, Tsanko, Doma Bhutia, Tshering, Girma, Tsion, Kwan, Tsun Yu, Ivanov, Tsvetomir, Iahmo, TT, Ashkar, Tuleen, Mabogoane, Tumi, Olobatoke, Tunde, Sholadoye, Tunde T., Mishra, Tushar Subhadarshan, Parker, Tyla, Ezomike, Uchechukwu, Dilibe, Uchenna, Kumbhar, Uday, Una, Uduak-Abasi, Grossi, Ugo, Ezidiegwu, Ugochukwu, Edith, Ugwuoke, Daspal, Ujjwal, Kalu, Ukoha Agwu, Dietz, Ulrich, Ronellenfitsch, Ulrich, Wirth, Ulrich, Abdullah, Umar, Rivolta, Umberto, Jayarajah, Umesh, Kanyan Kassim, Umu-Hera, Govindan, Unnikrishnan, Fernandes, Urânia, Akram, Usman, Mohammed Bello, Usman, Omara, Usra, Naidoo, Uvarasen, Mahendravarman, Vaishnaivy, Negoita, Valentina Madalina, Mariottini, Valentina, Murzi, Valentina, Zucchini, Valentina, Agbakwuru, Valentine, Armenta Tapia, Valeria Estefania, Gentilino, Valerio, Borgogni, Vanessa, Ng, Vanessa, Wolfschluckner, Vanessa, Silvestri, Vania, Žufić, Vanja, Gunasaegaram, Varman, Kamalathevan, Vasan, Pillay, Vasanthan, Neykov, Vasil, Kalles, Vasileios, Mousafeiris, Vasileios, Papadopoulos, Vasileios, Tsaousis, Vasileios, Tselepidis, Vasileios, Vougas, Vasileios, Georgilaki, Vasiliki, Nikolaou, Vasiliki, Themelidi, Vasiliki, Manchev, Vassil, Ioannou, Veatriki, Jha, Vedant Shekhar, Dragisic, Vedran, Sutharshan, Vengadasalam, Alonso, Veronica, Brocco, Veronica, Ongil Rodríguez, Verónica, Schirinzi, Veronica, Budyakova, Veronika, Naunova, Vesna, Panduro-Correa, Vicky, Ruiz López, Víctor Andrés, Bill, Victor, Dassah, Victor, Gonzabay, Víctor Eduardo, Etwire, Victor, Modekwe, Victor, Serna-Alarcon, Victor, De Donato, Victor Ugo, Duque Mallén, Victoria, Liu, Victoria, Sharma, Vidushi, Kumar, Vijaya, Muralidharan, Vijayaragavan, Kakotkin, Viktor, Enemuo, Vincent, Kudoh, Vincent, Osoka, Vincent, Siepaal, Vincent, Granata, Vincenza, Dinuzzi, Vincenza Paola, Lizzi, Vincenzo, Ricchiuti, Vincenzo, Mosca, Vinicio, Kanna D, Vinoth, Nair, Vipin Venugopal, Ledda, Virginia, Michael, Vishal, Singh, Vishavdeep, Govindasamy, Vishendran, Kollengode, Viswanathan V, Giordano, Vittoria, Morinelli, Vittoria, Lin, Vivian, Cuk, Vladica, Cijan, Vladimir, Çalik, Volkan, Bakshi, Vrushank, Ten, Vyacheslav, Ratheesh, Vysakh, Alsado, Wael, Mayo, Wafik, Yang, Wah, Rehman, Wajeeh Ur, Abbas, Walaa, Al-Khyatt, Waleed, Mabood, Waleed, Santucci, Walter, Yew, Wan Ting, Tahir, Warda, De Silva, Warusha Dhammika Dulantha, Wijenayake, Wasantha, Almadhoun, Waseem J.N., Alhroub, Wasef, Ebrahim, Wesam, Jabłoński, Wiktor, Krawczyk, Wiktor, Bhatti, William, Lai, William Kwan Ho, Petrushnko, Wilson, Afedo, Wisdom, Kasetsermwiriya, Wisit, Serednicki, Wojciech, Wysocki, Wojciech, Zerefa, Wondwossen Amtataw, Vagena, Xanthoula, Tarrado, Xavier, Papazarkadas, Xenofon, Po, Xiang Yuen, Ouadi, Yacine, Myla, Yacob, Haido, Yacoub, Hasan, Yafea, Karataş, Yağmur, Carpio Colmenares, Yahaira, Galvañ Félix, Yaiza, Balogun, Yakub Lekan, Maktabi, Yaman, Nerabani, Yaman, Fulgence, Yamuremye, De Silva, Yannick, Asar, Yara, Samer Morsy, Yara, Ghaleb, Yasameen Saif Saeed Mohammed, Vashishth, Yash, M S, Yashas, Manickchund, Yashoda, Sakaray, Yashwant, Kara, Yasin, Tosun, Yasin, Zwain, Yasir, Farag, Yasmeen, Jedidi, Yasmine, Seada, Yasmine, Aldebasi, Yasser, Ashour, Yasser, Badr, Yassin, Sarpong, Yaw, Alawneh, Yazan, Aung, Yee Lay, Orabi, Yehia, Lam, Yick Ho, Şen, Yigit Kaan, Koyluoglu, Yilmaz Onat, Huang, Yining, Mintz, Yoav, Perez, Yocarli, Chamara, Yohan, Melkamu, Yohannes, Maestre González, Yolanda, Dean, Yomna, Metaferia, Yonas Yilma, Malki, Yosra, Mohamed, Younis, A. Omar, Yousef, Alhammoud, Yousef, Allaoua, Yousef, Tanas, Yousef, El Okazy, Youssef, Kerolous, Youssef, Mohamed, Youssef, Al-Junaidi, Youssuf, Lakdawala, Yousuf, Lu, Yuann, Asano, Yukio, Altinel, Yuksel, Aktimur, Yunus Emre, Fishman, Yuri, Kudryavcev, Yurii, Tandoğan, Yusuf Iskender, Razafimandimby, Yves Michaël, Adofo-Asamoah, Yvonne, Şenol, Zafer, Odeh, Zahra, Benamrouche, Zahra Rayane, Alkhaier, Zahraa, Al-Sheikh Ali, Zaid, Zaher, Zain Aldin, Alnajjar, Zaina, Al-Balushi, Zainab, Alkhuzaie, Zainab, Khraim, Zakaria, Toutounji, Zakaria, Djama, Zakarya, Farraj, Zamil, Shah, Zamir Ahmad, Khan, Zara, Khan, Zarnigar, Abo Alarous, Zayn Alabden, Asaad, Zaynab, Demetrashvili, Zaza, Lorenc, Zbigniew, Brekalo, Zdrinko, Hannouneh, Zein Alabdin, Robertson, Zelda, Bady, Zeyad, Durna, Zeynep, Wong, Zhen Yu, Fozo, Zien Alabdin, Klib, Zienab, Chin, Ziling, Tamou, Zime Farid, Johnson, Zina, Shabello, Ziyad, Orzeszko, Zofia, Aljalabi, Zohal, Al-Azher El-Hamel, Zohour, Karampotaki, Zoi Rafaila, Valera Sanchez, Zoraida, Matkovic, Zoran, Azhar, Zubair, Qureshi, Zubaria, Correa López, Zulema Margarita, Balciscueta, Zutoia, Musilová, Zuzana, Katusic, Zvonimir, Osama, Zyad, and Dauksa, Zygimantas
Published: 2024
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40. The role of psychological resilience and aggression in injury prevention among martial arts athletes

Author: Ionuț Patenteu, Roman Gawrych, Mircea Bratu, Luciela Vasile, Ryszard Makarowski, Andrei Bitang, and Sarah Adriana Nica
Subjects: resilience, sports injury, martial arts, aggression, assertiveness, Psychology, BF1-990
Abstract: IntroductionFor martial artists, the ability to manage reactions in the face of adversity and bounce back after a stressful event can have major impact on performance. The scope of the research is to investigate martial artists’ level of resilience and aggression (Go-ahead, Foul play, and Assertiveness factors), what is specific to athletes and who have suffered from moderate and/or severe injuries (in terms of resilience and three factors of aggression examined), and test the possibility that a psychological variable under investigation can predict athletes’ injury severity.Materials and methodsA total sample of 154 athletes from striking combat sports—SC (karate, taekwondo, kickboxing, and boxing), grappling combat sports—GC (judo and BJJ), and mixed martial artists (MMA) participated in the research. For assessing resilience, the Romanian adaptation of the Brief Resilience Scale (BRS) was used, and for aggression, the Romanian adaptation of Makarowski’s Sports Aggression Questionnaire was used. An injury report form was also created and applied to athletes.ResultsThe post-hoc tests (after running a single-factor multivariate analysis of variance) revealed significant differences for resilience and Foul (violent) play between the sports disciplines analyzed. A significant positive correlation was found between athletes’ injury severity and assertiveness in SC and between injury severity and resilience in GC. Through the t-test for independent samples, it was highlighted that the average value for Foul (violent) play is significantly higher in athletes who have suffered mild, moderate, and/or severe injuries compared with martial arts athletes who have suffered from only mild/minor injuries. A binomial logistic regression was also performed to verify to what extent Foul play predicts athletes’ injury severity.ConclusionA low level of Foul (violent) play is linked with a decreased likelihood of moderate and/or severe injuries in martial arts athletes. The study findings suggest that resilience, foul play, and assertiveness have an important role in injury prevention among martial artists.
Published: 2024
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41. Meeting statement: Call to action for step-change in health behaviours

Author: Katrine Bach Habersaat, Anastasia Koylyu, Tiina Likki, Nils Fietje, Martha Scherzer, Vee Snijders, Alona Mazhnaia, Svenja Roy, Merita Berisha, Florie Miftari Basholli, Sabina Catic, Iveta Nagyova, Jonas Sivelä, Francesca Cirulli, Lien Van der Biest, Sladjana Baros, Šeila Cilović Lagarija, Mathilde Schilling, Hannah U. Nohlen, Maria João Forjaz, María Romay-Barja, İlayda Üçüncü, Edith Flaschberger, Tatjana Krajnc Nikolić, Olena Nesterova, Igne Lukmine, Yaiza Rivero-Montesdeoca, Julika Loss, Diana Andreasyan, Milena Carmina Oikonomou, Karina Godoy-Ramirez, Susanne Karregård, Robert Murphy, Jelena Niskanovic, Leen Van Brussel, Miguel Telo de Arriaga, Bogdan Wojtyniak, Cortney Price, Nurila Altymysheva, Karin Stein Jost, Roxane Berjaoui, Panu Saaristo, Joanna Glazewska, Marina Topuridze, Brett Craig, Parvina Mukhtarova, Marina Duishenkulova, Sarah Pace, Mary MacLennan, Marina Bachanovikj, Elke Jakubowski, Halima Zeroug-Vial, Ashley Gould, Adam Cutler, Mariken Leurs, Natalia Silitrari, Eugenia Claudia Bratu, Jenny Young, Viviane Melo Bianco, and Robb Butler
Subjects: Health, Behaviour, Culture, Policies, Services, Communication, Public aspects of medicine, RA1-1270
Abstract: Background: Enabling, supporting and promoting positive health-related behaviours is critical in addressing the major public health challenges of our time, and the multifaceted nature of behaviours requires an evidence-based approach. This statement seeks to suggest how a much-needed enhanced use of behavioural and cultural science and insights for health could be advanced. Study design and methods: and methods: Public health authorities of Europe and Central Asia and international partner organizations in September 2023 met in Copenhagen, Denmark, to discuss the way forward. Drawing on 1) country reporting to WHO, 2) interview study with public health authorities and 3) the meeting deliberations, this meeting statement was developed. Results: The meeting statement presents a joint call for step-change accelerated use of evidence-based approaches for health behaviours. Actionable next steps for public health authorities and international and regional development partners in health are presented. Conclusions: The way forward involves increased resource allocation, integration of behavioural insights into health strategies, advocacy through case and cost-effectiveness examples and capacity building.
Published: 2024
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42. Skin picking disorder in the elderly- What is the available evidence?

Author: O. Vasiliu, A. G. Mangalagiu, B. M. Petrescu, C. A. Candea, C. Tudor, D. Ungureanu, M. Miclos, C. Florescu, A. I. Draghici, R. E. Bratu-Bizic, M. Dobre, A. F. Fainarea, and M. C. Patrascu
Subjects: Psychiatry, RC435-571
Abstract: Introduction Excoriation disorder (ExD) is a pathology recognized by DSM-5, and it is considered a part of the obsessive-compulsive spectrum. ExD is associated with a high rate of psychiatric comorbidity (e.g., depression, ADHD, substance use disorders, etc.). Objectives The main objective of this review was to explore the available evidence to support the diagnosis and treatment of skin picking in elderly population. Methods A literature review of the available sources reporting on ExD in elderly patients, realized by searching three electronic databases (PubMed, Cochrane, Clarivate/Web of Science) but also the grey literature. All papers published between January 1990 and July 2023, including the terms “excoriation disorder”, “compulsive skin picking”, “dermatillomania” and “elderly” or “old-age patients” were reviewed. Results The information about ExD was extracted almost exclusively from reports on elderly patients with neurocognitive disorders. Tactile hallucinations, delusions of contamination, social isolation and focusing on own bodily sensations, and organic causes- dehydration, allergies, renal insufficiency, hepatic and pancreatic diseases, as well as toxic causes- e.g., adverse events of certain drugs should be investigated in elderly patients exhibiting signs of ExD. A differential diagnosis is very important in this population in order to find the most adequate treatment. Behavioral treatments, serotonergic antidepressants, and glutamatergic modulators have been explored in patients with ExD, although specific trials for elderly patients with this disorder are still lacking. However, case reports support the utility of several serotonergic antidepressants in the elderly. Conclusions ExD is a less explored disorder in the elderly, where an extensive differential diagnosis and screening for somatic/psychiatric comorbidities are needed. Trials exploring the potential treatments for ExD in old-age patients are also required for evidence-based case management. Disclosure of Interest None Declared
Published: 2024
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43. A Tubular Vena Cava Conduit Used to Lengthen a Kidney Transplant Renal Artery Injured During Organ Procurement

Author: Bogdan Bratu, Salomé Kuntz, Sophie Caillard, Nabil Chakfe, and Anne Lejay
Subjects: Kidney transplantation, Vascular surgical procedures, kidney, Diseases of the circulatory (Cardiovascular) system, RC666-701, Surgery, RD1-811
Abstract: Introduction: Organ transplantation is limited by the supply of transplantable organs, and the supply of organs cannot meet the needs of patients on the waiting list. Ensuring transplantation of any procured organ is therefore mandatory. Organ injury, mostly to the organ's vasculature, can occur during multi-organ procurement, preventing subsequent transplantation. In such a context, vascular reconstructions of arterial or venous organ injuries can be useful. Report: This report describes the case of an obese 64 year old female with a history of diabetic nephropathy who underwent a cadaveric kidney transplant (right kidney with one main renal artery, one inferior polar artery, one vein, and one ureter). The ex situ preparation of the graft revealed that the main renal artery was injured and cut close to the renal hilum (0.8 cm length, 6 mm diameter), not allowing graft implantation. In order to increase the length of the main renal artery, the donor inferior vena cava was used to create a tubular conduit, allowing subsequent graft implantation. Cold and warm ischaemic times were respectively 12 hours and 36 minutes, with immediate graft function. The patient was discharged on day 8 (serum creatinine level was 95 μmol/L). Twelve month follow up was uneventful (serum creatinine level was 108 μmol/L and duplex ultrasonography showed homogeneous blood flow throughout the graft). Discussion: This case report highlights the possibility of overcoming an injured kidney graft artery by creating a tubular vena cava conduit in order to allow subsequent transplantation. Vascular reconstructions of organs injured during procurement should be considered.
Published: 2024
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44. Organization of the epileptogenic zone and signal analysis at seizure onset in patients with drug‐resistant epilepsy due to focal cortical dysplasia with mTOR pathway gene mutations—An SEEG study

Author: Irina Oane, Andrei Barborica, Andrei Daneasa, Mihai Dragos Maliia, Jean Ciurea, Sergiu Stoica, Aurelia Dabu, Flavius Bratu, Camelia Lentoiu, and Ioana Mindruta
Subjects: epilepsy surgery, focal cortical dysplasia, mTOR mutation, SEEG, Neurology. Diseases of the nervous system, RC346-429
Abstract: Abstract Epilepsy surgery in genetic drug‐resistant epilepsy is a debated subject as more histological and molecular data are available. We retrospectively collected data from focal drug‐resistant epilepsy patients that underwent stereoelectroencephalography (SEEG) invasive recordings. Patients with nonlesional brain imaging or in whom a first epilepsy surgery failed to control seizures were selected. We computed and displayed the intracranial ictal onset activity pattern on structural imaging. Patients underwent epilepsy gene panel testing, next generation sequencing—NGS. Of 113 patients, 13 underwent genetic testing, and in 6 patients, a mechanistic target of rapamycin pathway gene germline mutation (mTOR) was identified. Brain imaging was nonlesional except for one patient in whom two abnormalities suggestive of focal cortical dysplasia (FCD) were found. Patients underwent tailored brain surgery based on SEEG data, tissue analysis revealed FCD and postsurgical outcome was favorable. Our findings are similar to previous case series suggesting that epilepsy surgery can be a treatment option in patients with mTOR pathway mutation. In patients with mTOR pathway mutation, the postsurgical outcome is favorable if complete resection of the epileptogenic zone is performed. Electrophysiological seizure onset patterns in FCDs associated with mTOR pathway mutations display low‐voltage fast activity as previously described.
Published: 2023
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45. CLINICAL ASPECTS OF THE ORAL MUCOSA IN PATIENTS WITH SLEEP-OCCURRING BRUXISM

Author: Sin Elena-Claudia, Bratu Cristina, Buștiuc Steliana-Gabriela, Raftu Gheorghe, and Elena-Claudia Coculescu
Subjects: clinical aspects, oral mucosa modifications, self-reported bruxism, sleep-occurring bruxism, Dentistry, RK1-715
Abstract: Aim of the study The objective of this study is represented by the identification of the clinical aspects of the oral mucosa in patients with bruxism occurring during sleep. Material and methods. The study group was represented by a number of 70 patients, women and men. The oral examinations were performed on a number of 51 patients who self-reported bruxism during sleep at the Oral Rehabilitation Clinic of the Faculty of Dentistry, “Ovidius” University in Constanța between January 2018 and January 2019. The collected data have were analyzed using the MICROSOFT-EXCEL program. Results. A number of 127 modifications in the oral mucosa were analyzed. The most frequent modifications were in the following regions: jugal mucosa (24%), inferior buccal alveolar mucosa (17%), superior buccal alveolar mucosa (10%), the dorsal surface of the tongue (10%). The presence of linea alba was observed in 51% of patients. The presence of geographic tongue (11.8%) and the presence of dental impressions (10.7%) was also observed. Conclusions. Oral mucosal modifications in patients with self-reported sleep bruxism are frequently found at the level of the jugal mucosa, inferior alveolar vestibular mucosa, superior alveolar vestibular mucosa and the dorsal surface of the tongue. Some of these modifications are manifestations in the context of bruxism, others have not been associated with bruxism until now.
Published: 2023

46. FUNCTIONAL TRAPS OF THE FULL ARCH IMPLANT SUPERSTRUCTURES IN IMPLANTOLOGY

Author: Bratu Emanuel Adrian, Borsanu Ioan, Rusu Laura-Cristina, Sinescu Cosmin, and Antonie Sergiu
Subjects: superstructures, implantology, full arch, monolithic dental material, numeric simulations, mechanical analysis, Dentistry, RK1-715
Abstract: Aim of the study is to analyse the mechanical problems of implant restorations: the precise passive fit, the fracture resistance-aging, the micro fractures, the change in colour and the design of both infrastructure and superstructure. Material and methods We evaluate the same full arch restoration with the five most used material combinations and a mechanical failure test and numeric design simulations of forces at bone level. Results: Generally, two extensions failed faster than the single extension. Conclusions The patients’ expectations on the success of the implant and the predictability are high compared to their reluctance towards treatment costs and duration; it is particularly important to clarify this aspect from the beginning of the treatment.
Published: 2023

47. THE CHALLENGES OF MAINTAINING ORAL HEALTH IN HEPATITIS C

Author: Cristina Raluca Iorga, Ana Magdalena Bratu, Razvan Leata, Mariana Ilie, Adrian Petru Radu, Gabi Topor, and Camelia Ana Grigore
Subjects: hepatitis c, oral health, infectious disease, Dentistry, RK1-715
Abstract: Hepatitis C is a global health problem, affecting millions of people and having significant implications for the whole organism. In this context, attention to oral health among people with hepatitis C is becoming increasingly important. Hepatitis C is a chronic viral infection of the liver, transmitted mainly by contact with infected blood, and its treatment involves the use of strong antiviral drugs. However, these treatments can have side effects and influence the oral health of patients. Adopting a regular oral hygiene regimen, including dental brushing, flossing and mouthwash, is an essential component in maintaining oral health for people with hepatitis C. Schedule regular visits to the dentist for dental exams and professional cleanings contributes to the early identification of oral problems and the prevention of complications.People undergoing treatment for hepatitis C should be aware of possible side effects, such as dry mouth, and take appropriate measures to manage these symptoms.
Published: 2023

48. DETECTING OF CONJUNCTIVAL MICROANGIOPATHY IN CHILDREN AND TEENAGERS WITH TYPE I DIABETES-A NEW PROPOSED APPROACH

Author: Carmen Tiutiuca, Geanina Totolici, Boev Monica, Ana Magdalena Bratu, Dana Tutunaru, Dinu Bogdan Tiutiuca, Ciprian Dinu, and Ciprian Florin Badea
Subjects: diabetes mellitus, conjunctival microcirculation, conjunctival index, Dentistry, RK1-715
Abstract: We demonstrate the efficiency of the conjunctival microcirculation evaluation via the processing technique, the analysis and the imagistic interpretation (using CorelDRAW and MATLAB) of the photos capturing the evolution of the conjunctival microcirculation throughout the course of the disease in children and teens with type 1 diabetes, on a prospective clinical study on a lot of 100 children with type 1 diabetes and values of glucose and glycosylated haemoglobin which illustrate a precarious metabolic control. The analysis through software techniques of the photos capturing the conjunctival circulation in a standardized area led to the elaboration of a numerical description of the pixels distribution providing values which reflect the density of the microvascularization in the corresponding sector. The average value of the black and white pixels was named index of the conjunctival circulation and was used as a tool to emphasise the emergence of the conjunctival microcirculatory modifications which were analysed in relation with the control batch and in correlation with the duration of the disease. In the case of diabetic children, the conjunctival index registered an average value of 450.55 exceeding the value of 250.17 which represents the average value of this parameter in healthy children. There are also significant differences of the conjunctival index depending on the duration of the disease; it displays a continuous increase for a duration of the disease up to 10-11 years, followed by a decrease. The technique proposed might represent a useful method in the surveillance of the conjunctival microcirculation in patients suffering from diabetes. In the study described here, it permitted the highlighting of some early manifestations, identifiable at the level of the conjunctival vessels, modifications which can be attributed to the diabetic disease.
Published: 2023

49. INNOVATIVE TREATMENT TECHNIQUES IN POLYCYSTIC OVARY SYNDROME (PCOS)

Author: Cristina Raluca Iorga, Ana Magdalena Bratu, Camelia Ana Grigore, Adrian Beznea, Adrian Petru Radu, Cristian Iorga, and Mihaela Alina Calin
Subjects: polycystic ovaries (pcos), laser therapy, hifu therapy, genetic therapy, Dentistry, RK1-715
Abstract: Polycystic ovary syndrome (PCOS) is a common condition among women in the fertile period and can have a wide range of symptoms including menstrual disorders, infertility, and, excessive hair growth and metabolic problems. PCOS treatment may vary depending on individual symptoms and patient goals, some of the emerging technologies and innovative approaches that have been investigated in the context of PCOS treatment are: laser therapy for ovarian cysts (HIFU), focused high-intensity ultrasound therapy, gene therapy , stem cell treatment , nutrigenomics and personalized diet , etc , artificial intelligence (AI) interventions. Each technique brings with it promises and challenges, and their implementation in clinical practice requires extensive clinical studies and attention to detail. It is essential to keep the balance between innovation and safety in order to ensure real benefits for patients. Despite the early stage of much research, these innovative approaches pave the way for more efficient and personalized PCOS management.
Published: 2023

50. DIABETIC NEUROPATHY: INNOVATIVE TREATMENT TECHNIQUES

Author: Mihaela Alina Calin, Ana Magdalena Bratu, Adrian Petru Radu, Burduloi Vlăduț Mirel, Camelia Ana Grigore, Cristian Iorga, and Cristina Raluca Iorga
Subjects: diabetic neuropathy, laser therapy (lllt), tens electrical stimulation, Dentistry, RK1-715
Abstract: Diabetic neuropathy represents a frequent and debilitating complication of diabetes, affecting the peripheral nervous system and contributing to symptoms such as pain, tingling, and numbness. In this review, we explore innovative treatment techniques that have been studied to alleviate the symptoms of diabetic neuropathy. Key aspects covered include low-level laser therapy (LLLT), transcutaneous electrical nerve stimulation (TENS), the use of antiepileptic and antidepressant medications, stem cell therapy, and the integration of virtual reality in pain therapy. LLLT has shown promise in stimulating nerve regeneration, while TENS provides a non-invasive approach to managing neuropathic pain. Antiepileptic and antidepressant medications have demonstrated significant benefits, and stem cell therapy is at the forefront of research for tissue regeneration. Additionally, the integration of virtual reality in pain therapy offers an innovative perspective, distracting patients from their symptoms and improving their quality of life. Managing diabetic neuropathy extends beyond conventional therapies, evolving constantly through the integration of innovative techniques with the potential to significantly enhance the quality of life for affected patients. It is essential to continue research and rigorously evaluate the effectiveness of these approaches, collaborating with healthcare professionals to provide personalized and efficient solutions.
Published: 2023

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