Search

Simple Summary: In mammals, serotonin (5-hydroxytriptamine, 5-HT) is involved in many metabolic functions, including intestinal peristalsis, vasoconstriction, sleep, appetite, anxiety, and depression. The investigative hypothesis underlying this study was that different ages and productive aptitudes may affect 5-HT, thyroid hormones, and cortisol plasma concentrations and could explain possible interactions among them in cows. Our results showed significantly lower T3 concentrations in milk production aptitude cows than in meat production aptitude ones, a significant effect of age on T4 concentrations both in beef and dairy aptitude cows, and a positive and significant correlation for T4 with T3 and 5-HT in meat production-only cows. Monitoring of 5-HT, THs, and cortisol circulating concentrations could be a practical application to monitor the animal's physiological adaptation processes. Cattle productivity, whether in terms of meat yield or milk production, is intricately regulated by a multitude of factors. Among them, hormone concentrations play a significant role, reflecting the complex interplay between endocrine regulation and physiological processes that ultimately determine the efficiency and yield of production. High concentrations of 5-hydroxytriptamine (5-HT) are associated with a reduced metabolic load at the onset of lactation and a lower milk yield. Thyroid hormones (THs) and cortisol also affect several metabolic pathways, including carbohydrate, protein, and lipid metabolism. The aim of this study was to assess if milk or meat aptitudes and age influence circulating 5-HT, THs, and cortisol concentrations, investigating the possible interactions among these parameters. The research was performed on 46 healthy cows of three different breeds. Enzyme-linked immunosorbent assay (ELISA) methods were used to quantify circulating 5-HT and cortisol concentrations, and an immunochemiluminescent analyzer was used for THs. For parameters exhibiting non-normal distributions, an ANCOVA model using age, aptitude, and their interaction as fixed factors was applied. Significant lower T3 concentrations were recorded in dairy cows than in meat cows. Moreover, T4 significantly decreased with advancing age both in cows aimed at milk and meat production. Lastly, T4 was positively correlated with T3 and 5-HT in meat production-oriented cows. [ABSTRACT FROM AUTHOR]

Simple Summary: The study evaluated the intraoperative isoflurane end-tidal concentration (isoflurane-sparing effect), clinical parameters, intraoperative antinociceptive effect, and postoperative analgesia in cats undergoing ovariohysterectomy treated with fentanyl, tramadol, or a combination of both. A reduction in the end-tidal isoflurane fraction and better analgesia were observed during fentanyl/tramadol infusion while no differences were found between the two drugs used alone. The results of this study suggest that the combination of fentanyl and tramadol could be proposed as a viable alternative anesthetic protocol in cats undergoing ovariohysterectomy. The aim of this study was to evaluate the end-tidal concentration of isoflurane required, clinical parameters, intraoperative antinociceptive effect, and postoperative analgesia in cats undergoing ovariohysterectomy, receiving fentanyl, tramadol, or fentanyl/tramadol. Sixty-six cats in three groups, were premedicated with dexmedetomidine and infused with one of the following treatments: fentanyl, tramadol, or fentanyl/tramadol combination. Anesthesia was induced with alfaxolone and maintained with isoflurane, titrated to keep heart rate, respiratory rate and systolic arterial pressure within target values recorded at endotracheal intubation. An intraoperative cumulative scale was performed. Postoperatively, a short form of the Glasgow Composite Measure Pain Scale Feline was used at 2, 12, and 24 h. The groups were similar for age, weight, dose of dexmedetomidine, and alfaxalone administered. A greater reduction in the end-tidal isoflurane fraction was observed with the combined fentanyl/tramadol infusion than with either fentanyl or tramadol alone. No differences in the end-tidal isoflurane fraction were found between fentanyl or tramadol alone. Hemodynamic stability associated with minimal cardiopulmonary changes, low response to noxious intraoperative stimulation, and low postoperative pain scores were also observed with the fentanyl/tramadol combination. The fentanyl/tramadol combination provided a reduction in the end-tidal isoflurane fraction compared with fentanyl or tramadol alone. [ABSTRACT FROM AUTHOR]

The coralligenous build-ups located on the Mediterranean shelf in front of Marzamemi (SE Sicily, Italy) represent useful natural examples to use in studying the relationship between skeletal organisms and non-skeletal components in marine bioconstructions. Coralligenous build-ups are formed in open marine systems, and their comparison with coeval bioconstructions (biostalactites) of confined environments, like submarine caves, allows depicting the complex interactions between metazoans and microbial communities in the formations of recent bioconstructions in different Mediterranean settings. In this study, two coralligenous build-ups were characterized in terms of organisms and sediments involved in their formation. The framework mainly consists of coralline algae and subordinate bryozoans and serpulids. Sponges affect the general morphology of the bioconstructions both interacting with skeletonized organisms and through bioerosion activity. The micrite or microcrystalline calcite is present in minor amounts compared to other components that form the build-ups and consists of two types: autochthonous (in situ) and allochthonous (detrital). Fine autochthonous micrite mineralized directly inside the framework cavities and shows aphanitic or peloidal fabric, produced by organomineralization processes of soft sponge tissues and microbial metabolic activity, respectively. The detrital micrite occurring inside cavities derives from external sources or erosion processes of the bioconstructions themselves. This component has been classified as organic or inorganic based on the organic matter contents deduced by UV epifluorescence. A great quantity of sponges live in cavities of the coralligenous build-ups and compete with carbonatogenic bacteria for the same cryptic spaces, limiting the production of microbialites. The sharing of a similar relationship between sponges and microbial communities by coralligenous concretion and biotic crusts of particular submarine caves suggests that this competition is not habitat-specific. On the contrary, it may develop in a range of environmental settings, from open to cryptic systems, and could be used to clarify the role of metazoans vs. microbialites in palaeoecological reconstructions. [ABSTRACT FROM AUTHOR]

Although Jerusalem is one of the most photographed places in the world, few works have focused on the existence of its former 800-year-old Maghrebi Quarter, located in the shadow of the Western Wall. Founded in 1193 by Saladin's son, al-Afdal Ali to house Muslim pilgrims from North Africa (today Morocco, Algeria, Tunisia, and Libya), the Quarter was razed by Israeli bulldozers on the night of 10-11 June 1967. Its 1,000 or so inhabitants were forced to flee within hours. Silenced by the occupation of East Jerusalem as part of the Six-Day War, the existence of the Maghrebi Quarter faded behind the walls of history. This research paper describes how 55 years after its razing, the selection of a corpus of archives, combined with 3D technology and Interprofessional collaborations between historians and 3D designers enable making a forgotten history accessible again. Beyond a discussion on methods and technical process, this research paper aims to highlight the potential applications of the data set and the 3D model not only for scholarly research but also for pedagogical purposes, for instance. [ABSTRACT FROM AUTHOR]

The article focuses on the online storytelling concerning the Xylella fastidiosa outbreak in the Apulia region (Italy), as represented by a collection of User-generated content retrieved from Facebook, YouTube, and Reddit over a time span of 6 years (>16k comments). We examine the episode as a revelatory case of framing mechanisms that, in many technoscientific conflicts, enable different epistemologies to compete on an equal basis: «mainstream» scientific knowledge, and «alternative» contents (i.e. «non-orthodox» science, local and traditional knowledge). We use Computer-Assisted Text Analysis (CATA) to investigate popular themes and their semantic vocabulary. We find that discourses on Xylella fastidiosa are strongly polarized and structured around two conflicts: «expertise vs. politics» on one hand, and «scientific vs alternative» solutions on the other. Then, we identify three main knowledge production strategies and introduce a typology of «non-mainstream» methods and cures, highlighting the formal traits and argumentation strategies that may have made them more credible than knowledge provided by «official» science. We nevertheless call for more research that may find a recursiveness in such framing mechanisms in the online representation of other technoscientific conflicts. [ABSTRACT FROM AUTHOR]

In the last decades, the popularity of video games has been increasing thanks to their unique ability to engage their audience and create empathy. Among them, serious games have additional purposes besides entertainment, such as learning and behaviour change. Serious games, in fact, have been successfully applied to different fields, including education, health, tourism, and cultural heritage. In this context, the paper describes a novel serious game developed for increasing awareness and promoting the Underwater Cultural Heritage (UCH). In particular, the paper focuses on the Dive in the Past Serious Game which allows users to simulate a virtual dive into the Mediterranean Sea to explore accurate and life-sized 3D reconstructions of underwater archaeological sites. The purpose of the game is twofold: to engage diver and non-diver tourists into a virtual interactive exploration of underwater sites through digital storytelling and challenges; to increase awareness and knowledge on Mediterranean UCH. This work has been carried out in the context of the MeDryDive project, an EU co-funded under the COSME Programme, which aims to create personalized dry dive experiences for the promotion of Mediterranean UCH sites as distinctive tourism destinations. [ABSTRACT FROM AUTHOR]