28 results on '"C. Iacoboni"'
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2. Poster session: Dobutamine stress echo
- Author
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C. Vizza, X. Jeanrenaud, M. Satendra, L. Monti, A. Kovacs, D. Vanoli, V. Charles, A. Kardos, M. Chiarlo, C. Gruner, C. Monaco, A. Kuch-Wocial, K. Mizia-Stec, L. Sargento, D. Kautznerova, N. Resseguier, G. Tamborini, C. Cruz, P. Jurzak, A. Cogo, E. Lira, D. Al Mesned, Y. Aizawa, A. Chmiel, R. Corti, K. Kim, G. N. Elkilany, M. Haarman, R. Badagliacca, R. Weber, R. Bruno, L. Di Pino, I. Kaplanis, D. Kalimanovska-Ostric, D. Tsounis, M. Varoudi, H. Yoon, P. Goncalves, G. Mpitsios, I. Garcia-Lunar, P. Min, R. Mogelvang, K. Gieszczyk-Strozik, A. Blundo, A. Tarr, E. W. Remme, David Garcia-Dorado, V. Petronilli, A. Patel, C. Sousa, R. M. Lang, J. Mcghie, V. Monivas Palomero, C. Nomura, H. Yoshikawa, N. Lagopati, M. Gomberg-Maitland, R. Kalil, H. K. Jeon, K. Mrabet, A. Riberi, C. Zito, A. Khalatbari, D. Tarasov, L. Fusini, P. Marques, S. Hassantash, I. Zimbarra Cabrita, M. Francone, A. Germain, A. Theron, J. Sousa, A. Kantorova, F. Collart, C. J. Vrints, A. Forteza, C. Tamburino, D. Cerna, S. Buccheri, M. Taborsky, I. P. Monte, F. Elmkies, A. Castro Beiras, S. Ranjbar, A. Perpinia, O. A. Tolba, R. Pretre, T. Chua, F. Fedele, M. Calcagnino, D. Dragulescu, M. Greutmann, M. Pepi, M. Bartesaghi, S. Urheim, R. Muscariello, F. Ben Moussa, W. Saib, M. Thameur, J. Ternacle, V. Matzraki, M. Ghannouchi, G. Kocabay, A. Margulescu, R. Sicari, R. Ippolito, M. Kloeckner, A. Toth, J. Gonzalez Mirelis, K. Sugi, M. Geleijnse, T. Otsuka, A. Hervold, S. Benyoussef, B. Basnyat, H. Suomi, L. Gargani, M. Stosic, P. Monney, J. Segovia Cubero, M. Karvandi, P. Sousa, J. Gonzalez-Mirelis, P. Caso, M. Murata, M. Vieira, C. Fulcheri, M. Júlia Maciel, P. Garcia-Pavia, M. Bobbo, J. Sun, B. Nardi, V. Pyrgakis, J. W. Kim, F. Alamanni, D. Ozel, A. Cordovil, S. Cimino, S. Papa, A. Carro, E. Leiballi, S. Karakas, J. Cho, C. Mornos, H. Masai, M. D'angelo, S. Mingo Santos, J. Kang, N. Nishiyama, J. Brugada, W. Tsang, Y. Yoon, B. Herzog, F. Dominguez Rodriguez, G. Ertl, E.R. Valsangiacomo Buechel, H. Shin, M. Palinsky, P. Gaudron, O. Gaemperli, A. Bouzas Mosquera, R. Bogle, J. Rodriguez-Palomares, N. Liel-Cohen, J. Burrello, M. Henein, H. Yilmaz, M. Laine, C. Foucher, K. Tanimoto, P. Schiattarella, G. Teixido, V. Schiano Lomoriello, M. R. El-Shanshory, N. Lousada, T. Minarik, F. Machado, G. Hashimoto, Y. Ishikawa, P. Atkinson, I. Zairi, B. Lee, V. Lanska, T. Biering-Sorensen, D. Vinereanu, H. Dores, M. Nakamura, R. Kockova, A. Chenzbraun, A. Manrique, N. A. Garcia, C. Zimmermann, L. Carpinteiro, H. Youn, J. Guimaraes, P. Meimoun, M. Mohammed, A. Gaspar, G. Styczynski, M. Castella, R. Esposito, A. Karavidas, F. Tosello, J. Mills, J. E. Sanderson, Y. Lau, D. Lee, C. Chin, M. Dostanic, D. Liu, P. Lupinek, T. Sato, M. Lewis, M. Reali, E. Cervesato, A. Apor, D. Sharif, S. Leggio, T. Ono, S. Wos, S. Kadrabulatova, S. Miyoshi, B. Milakovic, M. Gonzalez-Alujas, Y. Y. Lam, W. Tietge, M. Tramarin, L. Balzarini, E.-S. El-Hawary, G. E. Nagib Elkilany, P. Lim, P. Lindqvist, F. Veronesi, G. Flahaut, M. Thomas, A. Redheuil, Y. Ahn, M. Galderisi, M. Cavero Gibanel, J. Roquette, G. D. Lenders, F. Cicogna, P. Nihoyannopoulos, S. Taddei, C. Shahla, O. Mirea, A. Aleixo, E. Altekin, A. Milan, J. Roncalli, V. Mor-Avi, P. Crapanzano, S. Wang, A. Rodrigues, D. De Palma, M. Sitges, J. Peteiro, G. Maldonado, A. Nagy, J. Wang, M. Miglioranza, M. J. Claeys, J. Kluin, R. H. Strasser, J. Masura, B. Pezzuto, S. Aakhus, M C De Knegt, F. Broullon, N. Bhave, Y. Kusunose, R. Domburg, S. Moral Torres, J. Song, G. Carlomagno, P. Carrilho-Ferreira, A. Mornos, K. Sedlacek, Y. Villain, S. Arapi, M. Segetova, T. Le Tourneau, M. Kucuk, H. Tsuruta, J.-L. Monin, L. Badano, C. Mueller, C. Jorge, J. Kautzner, U. Schubert, L. Zhong, B. Suran, J. Clerc, I. Demir, S. Chamuleau, P. Tittel, E. Boussabah, P. Punjabi, L. Guimaraes, C. Magnino, B. Delasalle, D. Leone, J. Gruenenfelder, H. Blafield, F. Thuny, J. Jensen, J. Silva Cardoso, S. Stoebe, S. Sioua, K. Fukuda, M. Nocioni, P. Linden, V. Sanchez, D. Silva, V. Sikula, F. Pizzino, L. Kryze, A. Lebreiro, M. Deljanin-Ilic, A. Arsenio, S. Takatsuki, M. Kaldararova, A. Sikora-Puz, M. Cinello, S. Naffati, M. Pirscova, V. Lisignoli, A. Hagendorff, T. Iwaki, M. Niemann, E. Rees, U. Rosenschein, V. Vrsanska, C. A. Szmigielski, G. L. Nicolosi, G. Di Bella, D. Pfeiffer, R. Giorgi, K. Korpi, E. Paucca, M. Sanchez Garcia, S. Kammoun, M. Rodolico, Arturo Evangelista, I. Baka, J. Lima, C. Yu, B. Hong, C. Fischer, P. Morera, F. C. Tanner, R. Manganaro, M. Mezzapesa, B. Seifert, A. Berruezo, H. Guterman, K. Sveric, U. Wiklund, R. Sant'anna, R. Piazza, L. Oreto, L. Mont, J. Rosso, B. P. Paelinck, S. Severino, J. Park, S. Morhy, S. Mingo, A. Ledakowicz-Polak, L. Arcari, E. E.-S. El-Hawary, E. Caiani, R. Fabregas Casal, A. Bensaid, N. A. E.-A. El-Shitany, F. Veglio, L. Gutierrez, R. Massey, R. Mimo, A. Yanikoglu, A. Al Akhfash, J. Rodriguez Garrido, S. Kovalova, N. Patrascu, M. Liu, B. Bijnens, J.-L. Dubois-Rande, M. Suzuki, I. Garcia Lunar, D. Muraru, S. Iwanaga, R. Borras, R. Karpov, T. Nastasovic, T. Gonzalez-Alujas, M. Jasinski, H. Marques, W. Voelker, D. Maan Hasson, K. Murbrach, J. Yoon, M. Cusma-Piccione, S. Carerj, E. Hopp, D. A. Rees, M. Zielinska, M. Forkmann, M. Sotiropoulos, I. Zegri, Y. Neuder, V. Hraska, R. Iengo, I. Losano, P. Gripari, J. Avierinos, I. Simkova, M. Yaacobi, F. Weidemann, C. Sordelli, H. Jeong, T. Osaki, M. Kubanek, R. Sharma, M. Yamamoto, D. Bettex, J. Sivertsen, G. Bruno, A E Van Den Bosch, P. Kracht, P. L. Van Herck, J. Roos-Hesselink, D. Cozma, E. Teiger, L. Said, B. Freed, A. Loimaala, T. Pinho, L. Pomidori, A. Mantovani, A. Santoro, R. Kadour, R. Calabro, S. Rim, L. Sim, B. Merkely, P. Gueret, R. Jansen, G. Curatolo, C.H. Attenhofer Jost, C. Gambardella, V. Jarvinen, P. Hol, D. Mihalcea, P. Sogaard, D. Peluso, O. Kretschmar, F. Fang, H. Cuellar, F. Maffessanti, R Palma Dos Reis, J. Grapsa, A. Sharif-Rasslan, H. Kwon, P. Novak, R. Gallet, C. Sportouch, O. Enescu, H. Chung, M. Valtonen, D. Dawson, A. G. Fraser, M. Lyra Georgosopoulou, Q. Shang, V. Leonelli, L. Agati, A. Khalil, G. Habib, M. Cavero, A. Ionac, M. Florescu, S. Pescariu, L. Ascione, M. Carmo, A. Marouen, A. D'Andrea, S. Champagne, S. Iliceto, J. P. Halcox, M. Mizia, Z. Gasior, M. Cramer, S F de Marchi, S. Goncalves, L. Dal Bianco, N. Cortez-Dias, U. Richter, I. Santos, U. Naslund, E. Gonzalez Lopez, M. Rover, H. Vago, A. E.-A. El-Shitany, G Teixido Tura, M. Sramko, J. Necas, S. Fennira, M. Gomez Bueno, L. Zakhama, L. Costanzo, H. Zemir, F. Dunstan, R. Pecoraro, R. Hocking, L. Gabrielli, R. Tan, J. Tintera, L. Pratali, V. Monivas, B. Bouzas Zubeldia, B. Segafredo, T. Leiria, R. Mincu, A. Kaczynska, L. Petrescu, J. M. Bosmans, A. Ben Yaala, A. Ploussi, K. Hu, Z. Frikha, L. De Luca, E. Choi, J. Yanez Wonenburger, I. Serbanoiu, C. Iacoboni, J. Trochu, S. Montserrat, X. Luo, E. Pavlukova, D. Martinez Ruiz, G. Lazaros, B. Tan, D. Hudziak, J. Petrovicova, S. Herrmann, P. Biaggi, E. Picano, I. E. Rodrigus, Y. Lam, M. Jeong, M. Fedorco, P. Beltran Correas, C. Felix, L. Polak, C. Wunderlich, S. Hohlfeld, S. Tripepi, M. Haberka, R. Poscia, L. Halmai, A. Luycx-Bore, K. Tunstall, D. Becker, H. Dave, P. Lemarchand, and M. Carvalho
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Leading edge ,business.industry ,Reference values ,Healthy subjects ,Medicine ,Radiology, Nuclear Medicine and imaging ,Geometry ,General Medicine ,Edge (geometry) ,Cardiology and Cardiovascular Medicine ,business - Published
- 2012
- Full Text
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3. Poster Session: Right ventricular systolic function
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M. Altman, C. Bergerot, H. Thibault, A. Aussoleil, E. Skuldadt Davidsen, M. Barthelet, G. A. Derumeaux, J. Grapsa, I. Zimbarra Cabrita, J. Afilalo, S. Paschou, D. Dawson, G. Durighel, D. O'regan, L. Howard, J. Gibbs, P. Nihoyannopoulos, M. Morenate Navio, M. Mesa Rubio, M. D. Ortega, M. Ruiz Ortiz, F. Castillo Bernal, C. L. Del Pino, F. Toledano, M. P. Alvarez-Ossorio, S. Ojeda Pineda, J. S. D. Lezo Cruz-Conde, R. Jasaityte, P. Claus, A. Teske, L. Herbots, B. Verheyden, F. Rademakers, J. D'hooge, C. G. Tocchetti, C. Coppola, D. Rea, C. Quintavalle, L. Guarino, N. Castaldo, C. De Lorenzo, G. Condorelli, C. Arra, N. Maurea, D. Voilliot, O. Huttin, Y. Camara, W. Djaballah, S. Carillo, P. Zinzius, J. Sellal, M. Angioi, Y. Juilliere, C. Selton-Suty, P. Dobrowolski, A. Klisiewicz, E. Florczak, A. Prejbisz, E. Szwench, J. Rybicka, A. Januszewicz, P. Hoffman, A. Jurado Roman, S. De Dios Perez, J. M. M. De Nicolas, B. Diaz Anton, B. Rubio Alonso, R. Martin Asenjo, S. Mayordomo Gomez, L. Villagraz Tecedor, L. Blazquez, R. T. De Meneses, A. Bernard, A. I. Hernandez, A. Reynaud, C. Lerclercq, J. Daubert, E. Donal, R. Arjan Singh, S. Sivarani, S. Lim, W. Azman, M. Almeida, N. Cardim, V. Fonseca, V. Carmelo, S. Santos, T. Santos, J. Toste, W. Kosmala, A. Orda, B. Karolko, A. Mysiak, M. Przewlocka-Kosmala, K. Farsalinos, D. Tsiapras, S. Kyrzopoulos, E. Avramidou, D. Vassilopoulou, V. Voudris, H. Hayrapetyan, K. Adamyan, J. Montero Cabezas, C. Granda Nistal, B. Garcia Aranda, V. Sanchez Sanchez, A. Sestito, P. Lamendola, A. Di Franco, C. Lauria, G. Lanza, M. Kukucka, A. Unbehaun, S. Buz, A. Mladenow, H. Kuppe, M. Pasic, H. Habazettl, D. Gemma, N. Montoro Lopez, M. G. R. De Celix, T. Lopez Fernandez, F. De Torres Alba, D. I. Del Valle, U. Ramirez, J. Mesa, M. Moreno Yanguela, J. Lopez Sendon, G. W. Eveborn, H. Schirmer, P. Lunde, G. Heggelund, K. Rasmussen, Z. Wang, B. Lasota, K. Mizia-Stec, M. Mizia, A. Chmiel, T. Adamczyk, J. Chudek, Z. Gasior, A. Venkatesh, J. Johnson, A. Sahlen, L. Brodin, R. Winter, K. Shahgaldi, A. Manouras, S. Valbuena, A. Iniesta, T. Lopez, F. De Torres, P. Salinas, S. Garcia, M. Moreno, J. Lopez-Sendon, I. Lebid, T. Kobets, T. Kuzmenko, S. Katsanos, K. Yiu, M. Clavel, N. Nina Ajmone, F. Van Der Kley, J. Rodes Cabau, M. Schalij, J. Bax, P. Pibarot, V. Delgado, L. Fusini, G. Tamborini, M. Muratori, P. Gripari, N. Marsan, C. Cefalu', S. Ewe, F. Maffessanti, M. Pepi, N. Hasselberg, K. Haugaa, H. Petri, K. Berge, T. Leren, H. Bundgaard, T. Edvardsen, R. Ancona, S. Comenale Pinto, P. Caso, M. Coppola, O. Rapisarda, C. Cavallaro, F. Vecchione, A. D'onofrio, R. Calabro', R. Rimbas, S. Mihaila, O. Enescu, N. Patrascu, R. Dragoi, M. Rimbas, C. Pop, D. Vinereanu, S. Gustafsson, S. Morner, C. Gronlund, O. Suhr, P. Lindqvist, G. Di Bella, C. Zito, F. Minutoli, A. Madaffari, M. Cusma Piccione, A. Mazzeo, R. Massimo, M. Pasquale, G. Vita, S. Carerj, I. Rangel, A. Goncalves, C. Sousa, A. Correia, E. Martins, J. Silva-Cardoso, F. Macedo, M. Maciel, B. Pfeiffer, A. Rigopoulos, H. Seggewiss, M. Alvarez Fuente, T. Sainz Costa, C. Medrano, M. Navarro, D. Blazquez Gamero, J. Ramos, M. Mellado, M. De Jose, M. Munoz, E. Maroto, L. Gargani, P. Gosciniak, L. Pratali, G. Agoston, C. Bruni, S. Guiducci, M. Matucci Cerinic, A. Varga, R. Sicari, E. Picano, C. Zhao, M. Mei, C. Yeung, C. Siu, H. Tse, M. Florescu, L. Magda, R. Mincu, I. Daha, C. M. Stanescu, L. Chirila, C. Baicus, A. Vlase, G. Dan, M. Montoro Lopez, R. Florez Gomez, A. Alonso Ladreda, C. Itziar Soto, J. Rios Blanco, G. Guzman Martinez, B. Lichodziejewska, K. Kurnicka, S. Goliszek, M. Kostrubiec, O. Dzikowska-Diduch, M. Ciurzynski, A. Labyk, M. Krupa, P. Palczewski, P. Pruszczyk, C. C. De Sousa, A. Vigario, T. Pinho, J. Silva Cardoso, S.-J. Park, J.-E. Song, Y.-J. Lee, M.-R. Ha, S.-A. Chang, J.-O. Choi, S.-C. Lee, S. Park, J. Oh, A. Van De Bruaene, P. De Meester, R. Buys, L. Vanhees, M. Delcroix, J. Voigt, W. Budts, A. Blundo, S. Buccheri, I. P. Monte, S. Leggio, C. Tamburino, M. Sotaquira, R. Lang, E. Caiani, M. Floria, L. De Roy, O. Xhaet, D. Blommaert, J. Jamart, M. Gerard, O. Deceuninck, B. Marchandise, S. Seldrum, E. Schroeder, B. Unsworth, S. Sohaib, K. Kulwant-Kaur, L. Malcolme-Lawes, P. Kanagaratnam, I. Malik, B. Ren, H. Mulder, A. Haak, M. Van Stralen, T. Szili-Torok, J. Pluim, M. Geleijnse, J. Bosch, R. Baglini, A. Amaducci, G. D'ancona, S. Van Den Oord, Z. Akkus, G. Ten Kate, G. Renaud, E. Sijbrands, N. De Jong, A. Van Der Lugt, A. Van Der Steen, A. Schinkel, A. Bjallmark, M. Larsson, D. Grishenkov, L.-A. Brodin, T. Brismar, G. Paradossi, K. A. Sveen, T. Nerdrum, K. Hanssen, K. Dahl-Jorgensen, K. Steine, S. Cimino, G. Pedrizzetti, G. Tonti, E. Canali, V. Petronilli, F. Cicogna, L. Arcari, L. De Luca, C. Iacoboni, L. Agati, S. S. Abdel Moneim, S. Eifert Rain, M. Bernier, G. Bhat, M. Hagen, D. Bott-Kitslaar, R. Castello, S. Wilansky, P. Pellikka, S. Mulvagh, I. Delithanasis, J. Celutkiene, C. Kenny, M. Monaghan, W. Park, G. Hong, J. Son, S. Lee, U. Kim, J. Park, D. Shin, Y. Kim, K. Toutouzas, M. Drakopoulou, C. Aggeli, I. Felekos, C. Nikolaou, A. Synetos, K. Stathogiannis, E. Tsiamis, E. Siores, C. Stefanadis, B. Plicht, P. Kahlert, T. Grave, T. Buck, T. Konorza, M. Gursoy, T. Gokdeniz, M. Astarcioglu, Z. Bayram, B. Cakal, S. Karakoyun, M. Kalcik, R. Acar, G. Kahveci, M. Ozkan, W. Tsang, L. Weinert, S. Yurdakul, B. Avci, S. Sahin, B. Dilekci, S. Aytekin, F. Arenga, S. Hascoet, R. Martin, Y. Dulac, M. Peyre, C. Benzouid, K. Hadeed, P. Acar, D. Zakarkaite, V. Skorniakov, V. Zvironaite, V. Grabauskiene, J. Burca, L. Ciparyte, A. Laucevicius, G. Di Salvo, A. Rea, A. D'aiello, F. Del Gaizo, V. Pergola, A. D'andrea, G. Pacileo, R. Calabro, M. Russo, C. Dedobbeleer, A. Hadefi, R. Naeije, P. Unger, C. Mornos, D. Cozma, A. Ionac, A. Mornos, M. Valcovici, S. Pescariu, L. Petrescu, K. Hu, D. Liu, M. Niemann, S. Herrmann, M. Cikes, S. Stoerk, S. Knop, G. Ertl, B. Bijnens, F. Weidemann, M. De Knegt, T. Biering-Sorensen, P. Sogaard, J. Sivertsen, J. Jensen, R. Mogelvang, W. Lam, M. Tang, K. Chan, Y. Yang, F. Fang, J. Sun, C. Yu, Y. Lam, V. Panoulas, S. Sulemane, A. Bratsas, K. Konstantinou, M. Francone, T. Schau, M. Seifert, D. Ridjab, M. Schoep, M. Gottwald, M. Neuss, J. Meyhoefer, M. Zaenker, C. Butter, A. Tarr, S. Stoebe, D. Pfeiffer, A. Hagendorff, E. Maret, B.-M. Ahlander, P.-G. Bjorklund, J. Engvall, G. Staskiewicz, E. Czekajska-Chehab, P. Adamczyk, E. Siek, P. Przybylski, R. Maciejewski, A. Drop, C. Jimenez Rubio, G. Isasti Aizpurua, J. Miralles Ibarra, M. Al-Mallah, T. Somg, S. Alam, J. Chattahi, B. Zweig, K. Dhanalakota, S. Boedeker, K. Ananthasubramaniam, C. Park, K. March, S. Jones, J. Mayet, T. Tillin, N. Chaturvedi, A. Hughes, E. Hamodraka, E. Kallistratos, A. Karamanou, T. Tsoukas, D. Mavropoulos, N. Kouremenos, I. Zaharopoulou, N. Nikolaidis, D. Kremastinos, A. Manolis, M. Loboz-Rudnicka, J. Jaroch, Z. Bociaga, E. Kruszynska, B. Ciecierzynska, M. Dziuba, K. Dudek, I. Uchmanowicz, K. Loboz-Grudzien, D. Silva, A. Magalhaes, C. Jorge, N. Cortez-Dias, P. Carrilho-Ferreira, J. Silva Marques, I. Portela, C. Pascoa, A. Nunes Diogo, D. Brito, B. Roosens, G. Bala, S. Droogmans, J. Hostens, J. Somja, E. Delvenne, J. Schiettecatte, T. Lahoutte, G. Van Camp, and B. Cosyns
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medicine.medical_specialty ,business.industry ,Internal medicine ,medicine ,Cardiology ,Radiology, Nuclear Medicine and imaging ,General Medicine ,Session (computer science) ,Systolic function ,Cardiology and Cardiovascular Medicine ,business - Published
- 2012
- Full Text
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4. In vivo analysis of intraventricular fluid dynamics in healthy hearts
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L. De Luca, C. Iacoboni, Sara Cimino, Giovanni Tonti, Gianni Pedrizzetti, Luciano Agati, Emanuele Canali, V Petronilli, Cimino, S, Pedrizzetti, Gianni, Tonti, G, Canali, E, Petronilli, V, De Luca, L, Iacoboni, C, and Agati, L.
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Physics ,cardiac fluid mechanics ,General Physics and Astronomy ,In vivo analysis ,intraventricular pressure gradient ,Mechanics ,intraventricular fluid dynamics ,vortex ring ,Vortex ring ,Vortex ,Flow (mathematics) ,Intraventricular pressure ,cardiovascular system ,Fluid dynamics ,Outflow ,Left ventricular geometry ,cardiovascular diseases ,Mathematical Physics ,Biomedical engineering - Abstract
The intraventricular fluid dynamics is considered a potential novel indicator of cardiac health. This study present an in vivo assessment of the normal left ventricular flow in order to create a reference ground for the assessment of changes in presence of pathology. The systematic analysis is performed by Echographic PIV technique. Normal patients presented small differences in their overall flow features and parameters. The intraventricular vortex flow features a vortex region extending over most of the ventricular length and smoothly accompanies the flow from the inlet toward the outflow tract. The normal intraventricular pressure gradient features a base-to-apex alignment that properly matches with the left ventricular geometry that is adapt to properly sustain forces directed along its axis. The spatial analysis of cardiac flow provides novel information that integrate tissue deformation analysis and improve the understanding of the mechanisms involved in reducing the efficiency of LV pump.
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- 2012
- Full Text
- View/download PDF
5. Poster Session 3: Friday 9 December 2011, 08:30-12:30 * Location: Poster Area
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C. Kenny, S. Adhya, R. Dworakowski, B. Brickham, P. Maccarthy, M. Monaghan, A. Guzzo, F. Innocenti, S. Vicidomini, D. Lazzeretti, S. Squarciotta, E. De Villa, C. Donnini, F. Bulletti, E. Guerrini, R. Pini, K. Bendjelid, J. Viale, S. Duperret, V. Piriou, D. Jacques, K. Shahgaldi, C. Silva, F. Pedro, L. Deister, L.-A. Brodin, A. Sahlen, A. Manouras, R. Winter, N. Berjeb, C. Cimadevilla, J. Dreyfus, C. Cueff, M. Malanca, A. Chiampan, A. Vahanian, D. Messika-Zeitoun, D. Muraru, D. Peluso, L. Dal Bianco, M. Beraldo, E. Solda', M. Tuveri, U. Cucchini, A. Al Mamary, L. Badano, S. Iliceto, I. Almuntaser, G. King, S. Norris, C. Daly, E. Ellis, R. Murphy, T. Erdei, M. Denes, A. Kardos, C. Foldesi, A. Temesvari, M. Lengyel, A. Bouzas Mosquera, F. Broullon, N. Alvarez-Garcia, J. Peteiro, G. Barge-Caballero, M. Lopez-Perez, A. Lopez-Sainz, A. Castro-Beiras, M. Luotolahti, H. Luotolahti, I. Kantola, J. Viikari, M. Andersen, M. Ersboell, J. Bro-Jeppesen, F. Gustafsson, L. Koeber, C. Hassager, J. Moller, D. Coisne, C. Diakov, F. Vallet, B. Lequeux, P. Blouin, L. Christiaens, R. Esposito, A. Santoro, V. Schiano Lomoriello, R. Raia, C. Santoro, G. De Simone, M. Galderisi, G. Abdula, W. Kosmala, H. Szczepanik-Osadnik, M. Przewlocka-Kosmala, A. Mysiak, T. O' Moore-Sullivan, T. Marwick, Y. T. Tan, F. Wenzelburger, F. Leyva, J. Sanderson, P. Pichler, B. Syeda, P. Hoefer, A. Zuckermann, T. Binder, M. Fijalkowski, A. Koprowski, R. Galaska, K. Blaut, K. Sworczak, A. Rynkiewicz, S. Lee, W. Kim, L. Jung, H. Yun, M. Song, J. Ko, E. A. Khalifa, P. Szymanski, M. Lipczynska, A. Klisieiwcz, P. Hoffman, C. Jorge, J. Silva Marques, S. Robalo Martins, C. Calisto, M. Mieiro, S. Vieira, M. Correia, J. Carvalho De Sousa, A. Almeida, A. Nunes Diogo, C. Park, K. March, T. Tillin, J. Mayet, N. Chaturvedi, A. Hughes, V. Di Bello, C. Giannini, M. Delle Donne, F. De Sanctis, P. Spontoni, C. Cucco, A. Corciu, C. Grigoratos, F. Bogazzi, A. Balbarini, O. Enescu, B. Suran, M. Florescu, M. Cinteza, D. Vinereanu, Y. Higuchi, K. Iwakura, A. Okamura, M. Date, K. Fujii, N. Cortez-Dias, D. Silva, P. Carrilho-Ferreira, A. Magalhaes, S. Ribeiro, S. Goncalves, M. Fiuza, F. Pinto, R. Placido, A. Bordalo, P. Grzywocz, K. Mizia-Stec, J. Chudek, Z. Gasior, A. M. Maceira Gonzalez, J. Cosin Sales, E. Dalli, B. Igual, J. Diago, J. Aguilar, J. Ruvira, S. Cimino, G. Pedrizzetti, G. Tonti, E. Canali, V. Petronilli, F. Boccalini, A. Mattatelli, Y. Hiramoto, C. Iacoboni, L. Agati, D. Trifunovic, M. Ostojic, B. Vujisic-Tesic, M. Petrovic, I. Nedeljkovic, M. Banovic, M. Boricic-Kostic, G. Draganic, M. Tesic, C. Gavina, R. Lopes, A. Lourenco, J. Almeida, J. Rodrigues, P. Pinho, J. Zamorano, A. Leite-Moreira, F. Rocha-Goncalves, M.-A. Clavel, R. Capoulade, J. Dumesnil, P. Mathieu, J.-P. Despres, P. Pibarot, S. Bull, A. Pitcher, D. Augustine, J. D'arcy, T. Karamitsos, A. Rai, B. Prendergast, H. Becher, S. Neubauer, S. Myerson, J. Magne, E. Donal, L. Davin, K. O'connor, C. Pirlet, M. Rosca, C. Szymanski, B. Cosyns, L. Pierard, P. Lancellotti, A. Calin, B. Popescu, C. Beladan, R. Enache, L. Lupascu, C. Sandu, C. Ginghina, V. Kamperidis, S. Hadjimiltiadis, G. Sianos, K. Anastasiadis, V. Grosomanidis, G. Efthimiadis, H. Karvounis, G. Parharidis, I. Styliadis, C. Gonzalez Canovas, C. Munoz-Esparza, J. Bonaque Gonzalez, A. Fernandez, M. Salar Alcaraz, D. Saura Espin, E. Pinar Bermudez, M. Oliva-Sandoval, G. De La Morena Valenzuela, M. Valdes Chavarri, E. Brochet, L. Lepage, D. Attias, D. Detaint, D. Himbert, B. Iung, B. Pirat, S. Little, S. Chang, L. Tiller, R. Kumar, W. Zoghbi, A. P.-W. Lee, M. Hsiung, S. Wan, R. Wong, F. Luo, F. Fang, J. Xie, M. Underwood, J. Sun, C. Yu, R. Jansen, W. Tietge, K. Sijbrandij, M. Cramer, L. De Heer, J. Kluin, S. A. J. Chamuleau, T. Oliveras Vila, E. Ferrer Sistach, L. Delgado Ramis, J. Lopez Ayerbe, N. Vallejo Camazon, F. Gual Capllonch, C. Garcia Alonso, A. Teis Soley, X. Ruyra Baliarda, A. Bayes Genis, S. Negrea, C. Alexandrescu, F. Bourlon, F. Civaia, G. Dreyfus, S. Paetzold, O. Luha, R. Hoedl, G. Stoschitzky, K. Pfeiffer, D. Zweiker, B. Pieske, R. Maier, T. Sevilla, A. Revilla, J. Lopez, I. Vilacosta, R. Arnold, I. Gomez, J. San Roman, G. Nikcevic, A. Djordjevic Dikic, S. Djordjevic, S. Raspopovic, V. Jovanovic, B. Kircanski, S. Pavlovic, G. Milasinovic, I. Ruiz-Zamora, F. Cabrera Bueno, M. Molina, J. Fernandez-Pastor, J. Pena, A. Linde, A. Barrera, J. Alzueta, C. Bremont, A. Bensaid, H. Alonso, O. Zaghden, J. Nahum, J. Dubois-Rande, P. Gueret, P. Lim, S.-P. Lee, K. Park, H.-R. Kim, J.-H. Lee, H.-S. Ahn, J.-H. Kim, H.-K. Kim, Y.-J. Kim, D.-W. Sohn, M. Niemann, S. Herrmann, K. Hu, D. Liu, M. Beer, G. Ertl, C. Wanner, T. Takenaka, C. Tei, F. Weidemann, H. Madeira, M. Mendes Pedro, D. Brito, R. Ippolito, D. De Palma, S. Gati, D. Oxborough, M. Reed, A. Zaidi, S. Ghani, N. Sheikh, M. Papadakis, S. Sharma, V. Chow, A. Ng, T. Pasqualon, W. Zhao, D. Hanzek, T. Chung, T. Yeoh, L. Kritharides, L. Magda, D. Mihalcea, D. Jinga, R. Mincu, E. Ferrazzi, G. Segato, F. Folino, G. Famoso, M. Senzolo, R. Bellu, F. Corbetti, F. Tona, O. Azevedo, I. Quelhas, J. Guardado, M. Fernandes, V. Pereira, R. Medeiros, P. Sousa, W. Santos, S. Pereira, N. Marques, J. Mimoso, V. Marques, I. Jesus, L. Rustad, K. Nytroen, L. Gullestad, B. Amundsen, S. Aakhus, K. Linhartova, G. Sterbakova, J. Necas, S. Kovalova, R. Cerbak, N. Nelassov, N. Korotkijan, A. Shishkina, B. Gagieva, M. Nagaplev, O. Eroshenko, M. Morgunov, S. Parmon, S. Velthuis, M. Van Gent, M. Post, C. Westermann, J. Mager, R. Snijder, S. P. Koyalakonda, M. Anderson, M. Burgess, L. Bergenzaun, M. Chew, H. Ohlin, G. F. Gjerdalen, J. Hisdal, E. Solberg, T. Andersen, Z. Radunovic, K. Steine, T. Rutz, A. Kuehn, K. Petzuch, M. Pekala, J. Elmenhorst, S. Fratz, J. Mueller, A. Hager, J. Hess, M. Vogt, D. Van Der Linde, I. Van De Laar, M. Wessels, J. Bekkers, A. Moelker, H. Tanghe, F. Van Kooten, R. Oldenburg, A. Bertoli-Avella, J. Roos-Hesselink, A. Cresti, L. Fontani, P. Calabria, E. Capati, S. Severi, M. Lynch, S. Saraf, B. Sandler, S. Yoon, S. Kim, C. Ko, S. Ryu, Y. Byun, H. Seo, Q. Ciampi, F. Rigo, L. Pratali, S. Gherardi, B. Villari, E. Picano, R. Sicari, J. Celutkiene, D. Zakarkaite, V. Skorniakov, V. Zvironaite, V. Grabauskiene, J. Sinicyna, G. Gruodyte, K. Janonyte, A. Laucevicius, J. O'driscoll, K. Schmid, A. Marciniak, A. Saha, S. Gupta, R. Smith, R. Sharma, N. Alvarez Garcia, O. Prada, A. Rodriguez Vilela, G. Barge Caballero, M. Lopez Perez, A. Lopez Sainz, A. Castro Beiras, J. Kochanowski, P. Scislo, R. Piatkowski, M. Grabowski, M. Marchel, M. Roik, D. Kosior, G. Opolski, C. M. Van De Heyning, H. Mahjoub, H. Clausen, C. Basaggianis, J. Newton, A. Del Pasqua, A. Carotti, D. Di Carlo, E. Cetrano, A. Toscano, R. Iacobelli, C. Esposito, M. Chinali, G. Pongiglione, G. Rinelli, M. Larsson, A. Bjallmark, K. Caidahl, L. Brodin, H. Gao, M. Lugiez, C. Guivier, R. Rieu, J. D'hooge, G. Hang, C. Guerin, M. Menard, J.-U. Voigt, J. Dungu, G. Campos, R. Jaffarulla, S. Gomes-Pereira, N. Sutaria, C. Baker, P. Nihoyannopoulos, M. Bellamy, D. Harries, N. Walker, P. Pearson, J. Reiken, J. Batteson, R. Kamdar, F. Murgatroyd, A. D'andrea, L. Riegler, R. Scarafile, E. Pezzullo, G. Salerno, E. Bossone, G. Limongelli, M. Russo, G. Pacileo, R. Calabro', Y. Kang, J. Cui, H. Chen, C. Pan, X. Shu, A. Kiotsekoglou, S. Saha, R. Toole, S. Govind, A. Gopal, F. Crispi, B. Bijnens, E. Sepulveda-Swatson, J. Rojas-Benavente, J. Dominguez, M. Illa, E. Eixarch, M. Sitges, E. Gratacos, C. Prinz, R. Faludi, A. Walker, M. Amzulescu, T. Uejima, A. Fraser, J. Voigt, M. Esmaeilzadeh, M. Maleki, A. Amin, F. Vakilian, F. Noohi, Z. Ojaghi Haghighi, P. Nakhostin Davari, H. Bakhshandeh Abkenar, R. Rimbas, R. Dulgheru, A. Margulescu, M. D' Asaro, C. Mizzon, F. Parisi, B.-C. Jung, B.-Y. Lee, H.-J. Kang, M. Kim, Y. Kim, D. Cho, S. Park, S. Hong, D. Lim, W. Shim, H. Bellsham-Revell, S. Tibby, A. J. Bell, O. I. Miller, G. Greil, J. M. Simpson, R. A. Providencia, J. Trigo, A. Botelho, P. Gomes, L. Seca, S. Barra, A. Faustino, G. Costa, N. Quintal, A. Leitao-Marques, E. Nestaas, A. Stoylen, D. Fugelseth, C. Mornos, A. Ionac, L. Petrescu, D. Cozma, D. Dragulescu, A. Mornos, S. Pescariu, A. Fontana, M. Abbate, M. Cazzaniga, C. Giannattasio, G. Trocino, K. Laser, L. Faber, M. Fischer, H. Koerperich, D. Kececioglu, M. F. Elnoamany, A. Dawood, M. Elhabashy, Y. Khalil, N. Piriou, K. Warin-Fresse, M. Caza, G. Fau, D. Crochet, N. Xhabija, I. Allajbeu, E. Petrela, M. Heba, M. Barreiro Perez, M. Martin Fernandez, A. Renilla Gonzalez, J. Florez Munoz, O. Fernandez Cimadevilla, I. Alvarez Pichel, E. Velasco Alonso, D. Leon Duran, E. Benito Martin, S. Secades Gonzalez, L. Gargani, P. Pang, E. Davis, A. Schumacher, A. Silva Ferreira, N. Bettencourt, P. Matos, L. Oliveira, J. Cosin-Sales, M. Lopez Lereu, J. Monmeneu, J. Estornell, M. Tsverava, D. Tsverava, A. Varela, M. Salagianni, I. Galani, E. Andreakos, C. Davos, I. Ikonomidis, J. Lekakis, V. Tritakis, N. Kadoglou, J. Papadakis, P. Trivilou, S. Tzortzis, C. Koukoulis, I. Paraskevaidis, M. Anastasiou-Nana, G. Kim, H. Youn, P. Ibrahimi, G. Bajraktari, F. Jashari, A. Ahmeti, A. Poniku, E. Haliti, M. Henein, B. Pezo Nikolic, H. Jurin, D. Lovric, Z. Baricevic, I. Ivanac Vranesic, M. Lovric Bencic, A. Ernst, and J. Separovic Hanzevacki
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Novel technique ,business.industry ,Medicine ,Radiology, Nuclear Medicine and imaging ,Computer vision ,Nanotechnology ,General Medicine ,Contrast (music) ,Artificial intelligence ,Cardiology and Cardiovascular Medicine ,business - Published
- 2011
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6. Quantitative analysis of intraventricular blood flow dynamics by echocardiographic particle image velocimetry in patients with acute myocardial infarction at different stages of left ventricular dysfunction
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C. Iacoboni, V Petronilli, L. De Luca, Gianni Pedrizzetti, Francesco Cicogna, Luciano Agati, Sara Cimino, Giovanni Tonti, L., Agati, S., Cimino, G., Tonti, F., Cicogna, V., Petronilli, L., De Luca, C., Iacoboni, and Pedrizzetti, Gianni
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Male ,medicine.medical_specialty ,fluid mechanics ,Echocardiography, Three-Dimensional ,Myocardial Infarction ,Infarction ,Contrast Media ,Electrocardiography ,Ventricular Dysfunction, Left ,Internal medicine ,Image Interpretation, Computer-Assisted ,medicine ,Acute myocardial infarction ,Intraventricular flow ,Blood Flow Velocity ,Case-Control Studies ,Echocardiography ,Female ,Humans ,Middle Aged ,Medicine (all) ,Radiology, Nuclear Medicine and imaging ,In patient ,Myocardial infarction ,Ejection fraction ,business.industry ,General Medicine ,Blood flow ,Velocimetry ,medicine.disease ,Surgery ,Particle image velocimetry ,Cardiology ,Cardiology and Cardiovascular Medicine ,business ,Quantitative analysis (chemistry) - Abstract
Aims Left ventricular (LV) diastolic filling is characterized by the formation of a vortex that supports an efficient transit into systolic ejection. Aim of this study was to assess the intraventricular (IV) blood flow dynamics among patients with ST elevated myocardial infarction (STEMI) at different degrees of LV dysfunction, in the attempt to find novel indicators of LV pump efficiency. Methods and results Sixty-four subjects, 34 consecutive STEMI patients and 30 healthy controls, underwent before hospital discharge 2D speckle tracking echocardiography toassess global longitudinalstrain (GLS), and echo-particle image velocimetryanalysis to assess flow energetic parameters. Left ventricular volumes ejection fraction (LVEF) and global wall motion score index (GWMSI) were evaluated by 3D echocardiography. ST elevated myocardial infarction patients were subdivided into three groups according to LVEF. Energy dissipation, vorticity fluctuation, and kinetic energy fluctuation indexes, which characterize the degree of disturbance in the flow, exhibit a biphasic behaviour in STEMI patients when compared with controls, with the highest values in patients with still preserved LV function and progressive lower values with LV function worsening. Significant linear correlations were found between energy dissipation index and both LVEF and GLS (r ¼ 0.57, P , 0.001 and r ¼ 20.61, P ¼ 0.001, respectively). Kinetic energy fluctuation index significantly correlates with both LVEF (r ¼ 0.75, P , 0.001) and GLS (20.58, P ¼ 0.002). Finally, a significant correlation was observed between GWMSI and energy dissipation index (20.56, P ¼ 0.008). Conclusions The present study describes, for the first time, the progression of IV flow energetic properties in patients with acute myocardial infarction at different stages of LV dysfunction when compared with healthy controls. Further data are needed to assess the role of these parameters in the development and maintenance of LV dysfunction.
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- 2014
7. Plasma adrenomedullin and endothelin-1 concentration during low-dose dobutamine infusion: Relationship between pulmonary uptake and pulmonary vascular pressure/flow characteristics
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Roberto Badagliacca, Claudio Letizia, De Luca Leonardo, Giorgio Della Rocca, Petramala Luigi, Cotesta Dario, Carmine Dario Vizza, Susanna Sciomer, Roberto Poscia, Francesco Fedele, Serena Quattrucci, and C. Iacoboni
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Adult ,Lung Diseases ,Male ,Pulmonary Circulation ,medicine.medical_specialty ,Cardiac output ,pulmonary hemodynamics ,Physiology ,Clinical Biochemistry ,Blood Pressure ,Biochemistry ,Cellular and Molecular Neuroscience ,Endocrinology ,Internal medicine ,medicine.artery ,pulmonary hypertension ,medicine ,Humans ,Lung ,Aged ,end-stage pulmonary disease ,COPD ,business.industry ,Respiratory disease ,dobutamine ,Adrenergic beta-Agonists ,Middle Aged ,medicine.disease ,Pulmonary hypertension ,Respiratory Function Tests ,medicine.anatomical_structure ,Anesthesia ,Multivariate Analysis ,adrenomedullin ,endothelin-1 ,Pulmonary artery ,Cardiology ,Vascular resistance ,Female ,Dobutamine ,Peptides ,business ,medicine.drug - Abstract
To study the role of endothelin (ET-1) and adrenomedullin (AM) on pulmonary vascular pressure/flow characteristic (pulmonary arterial pressure/cardiac output (Pap/CO)) during low-dose dobutamine infusion.Case control study of 14 patients (12 men, 2 women) with severe lung disease (chronic obstructive pulmonary disease, COPD n=5; cystic fibrosis, CF n=9) and 5 control subjects (CTRL, 4 men, 1 woman). ET-1 and AM plasma levels in pulmonary artery (mixed venous blood, ven) and aorta or femoral artery (arterial, art), were measured at baseline and during dobutamine infusion (5-10-15 mcg kg(-1) min(-1)). The Ppa/CO coordinates obtained at baseline and during dobutamina infusion for each patients were used to calculate the Slope and Intercept by linear regression analysis.Baseline hemodynamics measurements were similar in the three groups with a trend towards a mild elevation in Ppa in CF group (Ppa mm Hg: CTRL 19+/-3.5, COPD 19.4+/-5.5, CF 22.7+/-7.5). Baseline plasma ET-1(ET-1ven pg ml(-1): CTRL 13.9+/-6.7, COPD 20.1+/-14, CF 20.4+/-7.1; ET-1art pg ml(-1): CTRL 16.7+/-6.4, COPD 20.1+/-11.7, CF 18.1+/-3.9) and AM (AMven pg ml(-1): CTRL 15.8+/-5, COPD 31.8+/-17.6, CF 27.7+/-7.6; AMart pg ml(-1): CTRL 15.9+/-1.4, COPD 21.4+/-3.8, CF 27+/-7.6) showed a trend towards higher value among patients' groups compared to the controls. Baseline ET-1 pulmonary gradient did not show significant difference among the three groups as well AM pulmonary gradient. Dobutamine infusion caused a comparable increase of heart rate and CO in the three groups. Mean pulmonary pressure had a trend towards a greater increase in COPD and CF than in controls, consequently, pulmonary Pap/CO relationship showed a steeper slope in patients' groups (Slope mm Hg L(-1) min(-1): CTRL 0.9+/-0.3, COPD 2.1+/-0.8 p0.02 vs. CTRL, CF 1.9+/-0.9 p0.03 vs CTRL). During dobutamine plasma ET-1 and AM showed a great individual variability resulting in no significant difference among groups. ET-1 pulmonary gradient showed a trend towards pulmonary uptake in patients' groups (ET-1art-ven pg min(-1): CTRL 2.7+/-2.9, COPD-6.1+/-7.8, CF -4+/-4.8) while AM pulmonary gradient did not show any particular pattern. During dobutamine ET-1 was significantly correlated to Pap/CO characteristics (Slope and ET-1ven, r=-0.59, p0.05; Slope and ET-1art-ven, r=-0.60, p0.05; Intercept and ET-1art-ven, r=0.63, p0.004), and ET-1art-ven was the only independent variable related to Slope and Intercept.In patients with moderate pulmonary vascular impairment, ET-1 pulmonary gradient, but not AM pulmonary gradient, is inversely correlated with pulmonary incremental resistance, suggesting a role of ET-1 in the regulation of pulmonary vascular resistance.
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- 2006
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8. Impact of Heart Rate on Myocardial Salvage in Timely Reperfused Patients with ST-Segment Elevation Myocardial Infarction: New Insights from Cardiovascular Magnetic Resonance
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Manuela Reali, Marco Francone, Luca Arcari, Laura De Luca, Sara Cimino, Nicola Galea, Iacopo Carbone, Luciano Agati, and C. Iacoboni
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Male ,medicine.medical_specialty ,Time Factors ,delayed-enhancement: ischemic myocardum ,Myocardial Infarction ,Magnetic Resonance Imaging, Cine ,Salvage therapy ,lcsh:Medicine ,Myocardial Reperfusion ,size ,Coronary artery disease ,Electrocardiography ,Coronary circulation ,Heart Rate ,Coronary Circulation ,Internal medicine ,blood-flow ,Heart rate ,Humans ,Medicine ,ST segment ,Myocardial infarction ,cardiovascular diseases ,Angioplasty, Balloon, Coronary ,CMR ,lcsh:Science ,Salvage Therapy ,primary coronary: angiplasty ,microvascular damage ,risk occlusion ,area ,Multidisciplinary ,medicine.diagnostic_test ,business.industry ,Myocardium ,lcsh:R ,Magnetic resonance imaging ,Middle Aged ,Prognosis ,medicine.disease ,medicine.anatomical_structure ,Cardiology ,cardiovascular system ,Female ,lcsh:Q ,business ,Research Article - Abstract
Background Previous studies evaluating the progression of the necrotic wave in relation to heart rate were carried out only in animal models of ST-elevated myocardial infarction (STEMI). Aim of the study was to investigate changes of myocardial salvage in relation to different heart rates at hospital admission in timely reperfused patients with STEMI by using cardiovascular magnetic resonance (CMR). Methods One hundred-eighty-seven patients with STEMI successfully and timely treated with primary coronary angioplasty underwent CMR five days after hospital admission. According to the heart rate at presentation, patients were subcategorized into 5 quintiles
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- 2015
9. Dipyridamole myocardial contrast echocardiography in patients with single-vessel coronary artery disease: Perfusion, anatomic, and functional correlates
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Francesco Fedele, Paolo Voci, Armando Dagianti, C. Iacoboni, Luciano Agati, R. Luongo, and Federico Bilotta
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Adult ,Male ,medicine.medical_specialty ,Video Recording ,Ischemia ,Contrast Media ,Blood Pressure ,Coronary Disease ,Coronary Angiography ,Coronary artery disease ,Electrocardiography ,Heart Rate ,Coronary Circulation ,Internal medicine ,Heart Septum ,medicine ,Humans ,Ventricular Function ,Aged ,Vascular disease ,business.industry ,Reproducibility of Results ,Signal Processing, Computer-Assisted ,Dipyridamole ,Blood flow ,Middle Aged ,Image Enhancement ,medicine.disease ,Intensity (physics) ,Stenosis ,Echocardiography ,Cardiology ,Feasibility Studies ,Female ,Cardiology and Cardiovascular Medicine ,business ,Perfusion ,Densitometry ,medicine.drug - Abstract
The aim of this study was to examine whether myocardial contrast echocardiography (MCE) may be used to study regional myocardial blood flow distribution during dipyriamole-induced hyperemia. MCE was performed before and after dipyridamole infusion in 11 patients with a proximal, significant left anterior descending (LAD) coronary artery stenosis. The relation between contrast-derived parameters and the degree of coronary narrowing and the occurrence of transient regional wall motion abnormalities was also investigated. In the territory supplied by left circumflex coronary artery, mean peak contrast intensity increased after dipyridamole from 50 ± 18 to 76 ± 27 IU (p < 0.001). In contrast, a significant reduction in mean peak intensity was observed after dipyridamole in the LAD territory (from 41 ± 27 to 13 ± 13 IU, p < 0.01). Similar results were obtained with the use of the area under the time-intensity curve. An increase in peak intensity ≥10 IU after dipyridamole administration separated normal regions from those supplied by a significant coronary artery lesion with a sensitivity of 91% and a specificity of 91%. Perfusion abnormalities were always detected by contrast echocardiography when septal motion abnormalities developed and, in five patients they were detected in the absence of clinical, electrocardiographic, and echocardiographic signs of ischemia. A weak correlation was found between both peak intensity and area under the curve and percent coronary diameter stenosis and cross-sectional area. In conclusion, dipyridamole MCE can be used during routine coronary angiography to assess myocardial blood flow distribution in patients with coronary artery disease. The intracoronary injection of contrast agents during dipyridamolestress echocardiography, may provide additional information on the functional significance of coronary lesions, thus helping in prognostic stratification and therapeutic decision making.
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- 1994
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10. Effects of abciximab and preprocedural glycemic control in diabetic patients undergoing elective coronary stenting
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C. Iacoboni, Giovanni De Persio, Monia Minati, Leonardo De Luca, and Francesco Fedele
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Blood Glucose ,Male ,medicine.medical_specialty ,Time Factors ,Abciximab ,Myocardial Infarction ,Placebo ,Preoperative care ,Diabetes Complications ,Immunoglobulin Fab Fragments ,Postoperative Complications ,Double-Blind Method ,Internal medicine ,Diabetes mellitus ,Preoperative Care ,medicine ,Myocardial Revascularization ,Humans ,Cumulative incidence ,Myocardial infarction ,Glycemic ,business.industry ,Coronary Stenosis ,Antibodies, Monoclonal ,Anticoagulants ,Middle Aged ,medicine.disease ,Hyperglycemia ,Cardiology ,Female ,Stents ,Cardiology and Cardiovascular Medicine ,business ,Mace ,medicine.drug - Abstract
In diabetic patients, the combination of abciximab with stenting has been demonstrated to be the standard of care to reduce target vessel revascularization (TVR) and mortality. Moreover, a preprocedural hyperglycemia has been associated with a higher rate of TVR after an elective stent implantation. We sought to evaluate the effects of abciximab and/or preprocedural glycemic control on 30 and 180 days of TVR and on 1-year major adverse cardiac events (MACE-cardiac mortality, TVR, and myocardial infarction) in diabetic patients undergoing elective coronary stenting.From January 2002 through May 2003, diabetic patients undergoing elective stenting of de novo coronary artery lesions were randomized to abciximab or placebo infusion. Preprocedural hyperglycemia was defined as fasting plasma glucoseor=126 mg/dL (7.0 mmol/L) immediately before the procedure.A total of 122 consecutive patients with diabetes (62.4 +/- 10.2 years, 80 men) were enrolled in the study. Sixty-nine (56.5%) were randomly assigned to receive abciximab (34 with and 35 without preprocedural hyperglycemia) and 53 (43.5%) to placebo (23 with and 30 without hyperglycemia). Target vessel revascularization was significantly lower in diabetic patients who received abciximab at 30 days (2.9% and 2.8% vs 8.7% and 6.6% in nonabciximab group with or without hyperglycemia, respectively, P.01) but not at 6 months (31.4% and 26.5% vs 30% and 28.7%, P = NS). Conversely, the cumulative incidence of MACE was significantly higher among diabetic patients with preprocedural hyperglycemia (64.7% and 65.2%) versus diabetic patients with preprocedural glycemic control (37.1% and 40%), treated with or without abciximab, respectively (P.05).A preprocedural hyperglycemia is associated with a higher rate of MACE, regardless of the use of abciximab, in diabetic patients undergoing elective coronary stenting.
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- 2005
11. Integrin beta 2-chain (CD18) over-expression on CD4+ T cells and monocytes after ischemia/reperfusion in patients undergoing primary percutaneous revascularization
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Daniele Accapezzato, C. Iacoboni, A. Di Roma, Giulia Benedetti, Gennaro Sardella, Marino Paroli, C. Musto, Vittorio Francavilla, Francesco Fedele, and Guglielmo Bruno
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CD4-Positive T-Lymphocytes ,Male ,medicine.medical_specialty ,Acute coronary syndrome ,medicine.medical_treatment ,Immunology ,Ischemia ,CD18 ,Coronary Disease ,CD8-Positive T-Lymphocytes ,Revascularization ,Monocytes ,Veins ,03 medical and health sciences ,0302 clinical medicine ,Angioplasty ,Internal medicine ,medicine ,Immunology and Allergy ,Humans ,ischemia/reperfusion ,primary percutaneous coronary intervention ,monocytes ,t lymphocytes ,cd18 ,Heart Atria ,Angioplasty, Balloon, Coronary ,Aged ,Pharmacology ,business.industry ,Middle Aged ,medicine.disease ,Flow Cytometry ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,CD18 Antigens ,Reperfusion Injury ,Conventional PCI ,Cardiology ,Female ,Stents ,business ,CD8 ,030215 immunology ,Artery - Abstract
β2-integrin subunit (CD18) plays an essential role in leukocyte recruitment and adhesion in sites of endothelial injury. We analyzed the surface expression of CD18 on T lymphocytes and monocytes in a series of patients presenting acute coronary syndrome (ACS) who underwent primary percutaneous intervention (PCI) for coronary artery revascularization. We found that basal CD18 expression on peripheral blood-derived CD4+ (but not CD8+) T lymphocytes was significantly increased in ACS patients as compared with age-matched healthy volunteers. During primary PCI, a significant increase in CD18 molecule density was detected immediately after balloon deflation (reperfusion) on both CD4+ T cells and monocytes obtained from the right atrium (RT) as compared with basal values. These data suggest that upregulation of CD18 molecules plays an important role in local recruitment of CD4+ T cells and monocytes to the site of endothelial damage after ischemia/reperfusion, therefore being responsible, at least in part, for the inflammatory-mediated complications associated with primary PCI.
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- 2004
12. Usefulness of 2D echo Doppler in the preoperative assessment of cystic fibrosis patients who are candidates for lung transplantation
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C. Iacoboni, Francesco Fedele, Carmine Dario Vizza, M. Antonelli, A. Di Roma, Carlo Lavalle, D. Padovani, F Coloni, Giuseppe Cimino, I. Flaishman, T Di Giacomo, Serena Quattrucci, Susanna Sciomer, Federico Venuta, G. Della Rocca, and Erino A. Rendina
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Adult ,Male ,Duplex ultrasonography ,medicine.medical_specialty ,Pancreatic disease ,Cystic Fibrosis ,medicine.medical_treatment ,Cystic fibrosis ,medicine ,Lung transplantation ,Humans ,Transplantation ,Lung ,business.industry ,Respiratory disease ,Ultrasonography, Doppler ,medicine.disease ,Pulmonary hypertension ,Surgery ,medicine.anatomical_structure ,Female ,Radiology ,business ,Lung Transplantation - Published
- 2001
13. Degree of residual stenosis of the infarct-related artery. Another variable affecting recovery of regional function after thrombolysis
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M, Penco, A, Dagianti, S, Romano, C, Iacoboni, A, Vitarelli, and F, Fedele
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Adult ,Male ,medicine.medical_specialty ,Asynergy ,medicine.medical_treatment ,Myocardial Infarction ,acute myocardial infarction ,Collateral Circulation ,Coronary Angiography ,Group B ,Ventricular Function, Left ,left ventricular function ,Internal medicine ,Coronary patency ,Fibrinolysis ,Image Processing, Computer-Assisted ,Medicine ,Humans ,Thrombolytic Therapy ,Myocardial infarction ,Aged ,Chemotherapy ,business.industry ,Thrombolysis ,Middle Aged ,medicine.disease ,Urokinase-Type Plasminogen Activator ,medicine.anatomical_structure ,Treatment Outcome ,quantitative coronary angiography ,Tissue Plasminogen Activator ,Cardiology ,Population study ,Female ,Cardiology and Cardiovascular Medicine ,business ,Artery - Abstract
AIMS The aim of this study was to analyse the relationship between infarct-related artery residual stenosis, assessed by quantitative coronary angiography, and left ventricular function changes during the in-hospital period in patients with acute myocardial infarction undergoing thrombolytic treatment. METHODS AND RESULTS The study population consisted of 90 patients with acute myocardial infarction treated with thrombolysis within 6 h of the onset of symptoms. Left ventricular function was serially assessed by an echocardiographic asynergy score (before thrombolysis and pre-discharge). Left ventricular end-diastolic and end-systolic volumes were also calculated. Coronary stenosis was evaluated by computer-assisted videodensitometric analysis at pre-discharge coronary angiography. Three subgroups were identified on the basis of left ventricular function changes: 25 patients (Group A) with regional myocardial improvement (echo score from 7.5 +/- 3.5 to 4.3 +/- 3.2), 51 (Group B) with no variation in echo score (4.8 +/- 2.7) and 14 (Group C) with myocardial regional worsening (echo score from 4.4 +/- 2.1 to 8.8 +/- 2.4). Group A patients exhibited a very high incidence of infarct-related artery patency (23/25 patients, 92%) vs 71% with unchanged (Group B) and 14% (Group C) with worsening regional left ventricular function (P < 0.001). Subdivision of the study population on the basis of residual stenosis severity showed that a significant improvement in left ventricular function was present only in the subgroup with residual stenosis < 75% (echo score from 5.2 +/- 3.4 to 3.6 +/- 2.9, P < 0.001). CONCLUSION These results support the important role exerted by complete coronary patency after thrombolysis in inducing left ventricular function recovery, and the poor functional improvement in patients with incomplete coronary patency.
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- 1998
14. Influence of residual perfusion within the infarct zone on the natural history of left ventricular dysfunction after acute myocardial infarction: a myocardial contrast echocardiographic study
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Camillo Autore, C. Iacoboni, Luciano Agati, Armando Dagianti, R. Luongo, Francesco Fedele, Federico Bilotta, Maria Penco, and Paolo Voci
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Adult ,Male ,medicine.medical_specialty ,Myocardial Infarction ,Hemodynamics ,Coronary Angiography ,Ventricular Function, Left ,Coronary artery disease ,Internal medicine ,Coronary Circulation ,Hospital discharge ,Medicine ,Humans ,Myocardial infarction ,Serum Albumin ,Aged ,business.industry ,Reproducibility of Results ,Middle Aged ,medicine.disease ,Prognosis ,Myocardial Contraction ,Natural history ,medicine.anatomical_structure ,Echocardiography ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business ,Infarct zone ,Perfusion ,Artery ,Follow-Up Studies - Abstract
Objectives. This study used myocardial contrast echocardiography to investigate the extent of residual perfusion within the infarct zone in a select group of patients with recently reperfused myocardial infarction and evaluated its influence on the ultimate infarct size. Background. Limited information is available on the status of myocardial perfusion within postischemic dysfunctional segments at predischarge and on its influence on late regional and global functional recovery. Methods. Twenty patients with acute myocardial infarction were selected for the study. Patients met the following inclusion criteria: 1) single-vessel coronary artery disease; 2) patency of infarct-related artery with persistent postischemic dysfunctional segments at predischarge; 3) stable clinical condition up to 6 months after hospital discharge. All selected patients underwent coronary angiography and myocardial contrast echocardiography before hospital discharge and repeated the echocardiographic examination 6 months later. Patients were grouped according to the pattern of contrast enhancement in predischarge dysfunctional segments. Results. In nine patients (group I), the length of segments showing abnormal contraction coincided with that of the contrast defect segments. In the remaining 11 patients (group II), postischemic dysfunctional segments were partly or completely reperfused. There was no difference between the two groups in asynergic segment length at predischarge (7.3 ± 2.5 vs. 7.2 ± 4.3 cm, p = NS). At follow-up study, asynergic segment length was significantly reduced in group II patients, whereas no changes were observed in group I patients (from 7.2 ± 4.3 to 4.7 ± 3.7 cm, p < 0.005; and from 7.3 ± 2.5 to 7.5 ± 2.9 cm, p = NS, respectively). Conclusions. Among patients with a predischarge patent infarct-related artery, further improvement in regional and global function may be expected during follow-up when residual perfusion in the infarct zone is present.
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- 1994
15. [Early isovolumetric relaxation: correlation with the densitometric analysis of coronary stenosis]
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R, Luongo, C, Iacoboni, L, Arata, A, Di Roma, A, Dagianti, G, Sarli, and F, Fedele
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Male ,Time Factors ,Diastole ,Humans ,Coronary Disease ,Female ,Constriction, Pathologic ,Middle Aged ,Coronary Angiography ,Ventricular Function, Left - Abstract
Early relaxation is characterized by a segmental outward wall movement during isovolumic relaxation. There is still no general agreement as to its significance. Some Authors have considered the phenomenon to be a specific marker of isolated coronary narrowing, others have regarded it as a normal variation of left ventricular relaxation and still others concluded that it is a compensatory phenomenon to local ischemia in another region. We used a method of quantitative assessment of regional left ventricular function and a videodensitometric analysis of coronary stenosis. In our study we didn't observe an improved systolic function of the regions that presented early relaxation, but a slight non significant reduction. We did neither observe any correlation between early relaxation and ischemia provoked by stress test nor between early relaxation and coronary artery disease. The amplitude of early relaxation was not statistically different between patients with and without stenosis of left anterior descending artery. We conclude that early relaxation is a normal variation of left ventricular relaxation.
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- 1992
16. Physiologic role of coronary PGI2 and PGE2 in modulating coronary vascular response to sympathetic stimulation
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Armando Dagianti, Rosanna Abbate, Francesco Bonechi, Sergio Castellani, L. Arata, Gian Gastone Neri Serneri, Francesco Fedele, Domenico Prisco, Gian Franco Gensini, and C. Iacoboni
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Adult ,Male ,medicine.medical_specialty ,Sympathetic Nervous System ,Prostaglandin ,Hemodynamics ,Prostacyclin ,Dinoprostone ,chemistry.chemical_compound ,Coronary circulation ,Coronary Circulation ,Internal medicine ,medicine ,Humans ,Aspirin ,business.industry ,Cold pressor test ,Coronary Vessels ,Epoprostenol ,Cold Temperature ,Vasodilation ,medicine.anatomical_structure ,Endocrinology ,chemistry ,Ketoprofen ,Anesthesia ,Circulatory system ,Coronary vessel ,Vascular resistance ,Female ,Vascular Resistance ,lipids (amino acids, peptides, and proteins) ,Cardiology and Cardiovascular Medicine ,business ,medicine.drug - Abstract
To investigate a physiologic role of coronary prostacyclin (PGI2) and prostaglandin E2 (PGE2) 30 patients who were not affected by coronary heart disease were evaluated for coronary hemodynamics and coronary PGI2 and PGE2 production. Inhibition of coronary prostaglandin biosynthesis by ketoprofen (1 mg/kg) or aspirin (15 mg/kg) administered intravenously did not significantly change coronary hemodynamics in resting conditions. In all patients cold pressor tests induced significant increases in coronary blood flow (p less than 0.001) and decreases in coronary vascular resistance (p less than 0.001) without changes in cardiac oxygen extraction and with consequent increases in calculated myocardial oxygen consumption. Simultaneously, a marked increase in coronary PGI2 (as 6-keto-PGF1 alpha) and PGE2 formation was observed (p less than 0.001). Both ketoprofen (1 mg/kg) and aspirin (15 mg/kg) administration completely abolished PGI2 and PGE2 formation that was induced by cold pressor test and caused a paradoxical increase in coronary vascular resistance (ketoprofen: p less than 0.02; aspirin: p less than 0.05). The results of this study support a physiologic role for the coronary prostaglandins in modulating coronary vascular response to sympathetic stimulation in nonischemic patients.
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- 1990
17. Usefulness of the dipyridamole-Doppler test for diagnosis of coronary artery disease
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L. Arata, Armando Dagianti, Francesco Fedele, C. Iacoboni, Carlo Peraldo Neja, Carmine Dario Vizza, Luciano Agati, Carla Manzara, and Maria Penco
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Adult ,Male ,medicine.medical_specialty ,Myocardial ischemia ,Hemodynamics ,Coronary Disease ,Doppler echocardiography ,Coronary Angiography ,Coronary artery disease ,symbols.namesake ,STRESS ECHOCARDIOGRAPHY ,Internal medicine ,medicine ,Humans ,Aged ,Observer Variation ,medicine.diagnostic_test ,business.industry ,Stroke volume ,Dipyridamole ,Middle Aged ,medicine.disease ,Echocardiography, Doppler ,Doppler test ,Echocardiography ,Cardiology ,symbols ,Female ,Cardiology and Cardiovascular Medicine ,business ,Doppler effect ,medicine.drug - Abstract
Two-dimensional and Doppler echocardiographic studies and a hemodynamic investigation were performed during dipyridamole testing in 42 subjects (13 control subjects and 29 patients with coronary artery disease [CAD]), to evaluate the ability of dipyridamole Doppler echocardiography in identifying patients with ischemic left ventricular dysfunction. In the control group, after dipyridamole infusion, Doppler-derived parameters increased significantly from baseline (p less than 0.001). In patients with CAD, peak flow velocity, flow velocity integral and stroke volume failed to increase after dipyridamole infusion (0.89 +/- 0.21 to 0.85 +/- 0.18 m/s, difference not significant; 14 +/- 3 to 12 +/- 4 cm, difference not significant, and 56 +/- 13 to 50 +/- 14 ml/beat, p less than 0.05, respectively). Heart rate, rate pressure product, systemic vascular resistance and mean right atrial pressure had similar variations in the 2 groups. Changes in the 3 Doppler-derived parameters are closely related to the variations of peak positive dP/dt, stroke volume (thermodilution) and left ventricular end-diastolic pressure and are closely related to the coronary angiography jeopardy score and to the appearance of wall motion abnormalities. Thus, by combining Doppler and 2-dimensional echocardiography, dipyridamole-induced myocardial ischemia may be detected in a high percentage of CAD patients, providing a sensitive tool for identifying patients with high-risk coronary artery anatomy.
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- 1990
18. Alternative pathway of angiotensin II production: role of human chymase in left ventricular remodeling
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Francesco Fedele, L Fumagalli, E. De Santis, C. Iacoboni, D. Ricci, M. Piccininno, M.C. Volponi, and G. Fedeli
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Angiotensin receptor ,Angiotensin II receptor type 1 ,business.industry ,Alternative complement pathway ,medicine ,Chymase ,Pharmacology ,Ventricular remodeling ,medicine.disease ,business ,Cardiology and Cardiovascular Medicine ,Angiotensin II - Published
- 1998
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19. [Untitled]
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Francesco Fedele, Erino A. Rendina, Federico Venuta, Paolo Pietropaoli, Giorgio Della Rocca, Carmine Dario Vizza, Federico Pierconti, C. Iacoboni, Giovanni Schmid, and Di Angelo Roma
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medicine.medical_specialty ,Inhalation ,business.industry ,medicine.medical_treatment ,Cardiac index ,Hemodynamics ,Critical Care and Intensive Care Medicine ,medicine.disease ,Pulmonary hypertension ,Nitric oxide ,chemistry.chemical_compound ,chemistry ,Internal medicine ,Anesthesia ,medicine ,Cardiology ,Lung transplantation ,Dobutamine ,Airway ,business ,medicine.drug - Abstract
The use of low-dose dobutamine to maintain hemodynamic stability in pulmonary hypertension may have a detrimental effect on gas exchange. The aim of this study was to investigate whether inhaled nitric oxide (INO), dobutamine and a combination of the two have beneficial effects in patients with end-stage airway lung disease and pulmonary hypertension. Hemodynamic evaluation was assessed 10 min after the administration of each drug and of their combination, in 28 candidates for lung transplantation. Administration of INO caused a reduction in mean pulmonary arterial pressure (MPAP), an increase in PaO2 with a significant reduction in venous admixture effect (Qs/Qt).Dobutamine administration caused an increase in cardiac index and MPAP, with a decrease in PaO2 as a result of a higher Qs/Qt. Administration of a combination of the two drugs caused an increase in the cardiac index without MPAP modification and an increase in PaO2 and Qs/Qt. Dobutamine and INO have complementary effects on pulmonary circulation. Their association may be beneficial in the treatment of patients with mild to moderate pulmonary hypertension.
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- 2001
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20. Tumor necrosis factor alpha blood levels as a potential marker of stenosis in patients undergoing percutaneous transluminal coronary balloon angioplasty
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L. Addonisio, A. Di Roma, D. Di Donato, Armando Dagianti, F. Fedale, and C. Iacoboni
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medicine.medical_specialty ,Percutaneous ,business.industry ,Coronary balloon angioplasty ,medicine.disease ,Stenosis ,Internal medicine ,medicine ,Cardiology ,In patient ,Tumor necrosis factor alpha ,Radiology ,Cardiology and Cardiovascular Medicine ,business - Published
- 1998
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21. Use of myocardial contrast echocardiography in identifying patients with failed reperfusion after thrombolysis in acute myocardial infarction: Comparison with TIMI myocardial perfusion grade and clinical markers of reperfusion
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Stefania Funaro, G. Veneroso, Francesca De Maio, Luciano Agati, Rachele Adorisio, F. Celani, Mariapina Madonna, C. Iacoboni, and Francesco Fedele
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medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Electrocardiography in myocardial infarction ,Thrombolysis ,medicine.disease ,Myocardial contrast echocardiography ,Internal medicine ,medicine ,Cardiology ,Myocardial infarction ,business ,Cardiology and Cardiovascular Medicine ,Perfusion ,TIMI - Full Text
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22. Tissue level perfusion after primary or rescue coronary angioplasty in acute myocardial infarction: A myocardial contrast echocardiography study
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Rachele Adorisio, Francesco Fedele, Mariapina Madonna, F. Celani, Stefania Funaro, Giulia Benedetti, Luciano Agati, C. Iacoboni, and Francesca De Maio
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medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Electrocardiography in myocardial infarction ,Tissue level ,medicine.disease ,Myocardial contrast echocardiography ,Internal medicine ,Angioplasty ,medicine ,Cardiology ,Myocardial infarction ,Cardiology and Cardiovascular Medicine ,business ,Perfusion - Full Text
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23. Immunological and genetic kinetics from diagnosis to clinical progression in chronic lymphocytic leukemia
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Marta Crespo, Bárbara Tazón-Vega, Clara Franco-Jarava, José A. García-Marco, Genís Parra, Gloria Iacoboni, Juan C. Nieto, Isabel Jiménez, Carles Palacio-García, Francesc Bosch, Anna Esteve-Codina, Rafael Valdés-Mas, Sabela Bobillo, Pau Abrisqueta, Lluis Puigdefàbregas, Júlia Carabia, Magdalena Munuera, María José Terol, Institut Català de la Salut, [Jiménez I, Nieto JC, Carabia J, Munuera M, Puigdefàbregas L, Crespo M] Experimental Hematology, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. [Tazón-Vega B, Abrisqueta P, Bobillo S, Palacio-García C, Iacoboni G, Bosch F] Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain. Servei d’Hematologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Experimental Hematology, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. [Franco-Jarava C] Servei d’Immunologia, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain, and Vall d'Hebron Barcelona Hospital Campus
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Chronic lymphocytic leukemia ,T cell ,Leucèmia limfocítica crònica - Diagnòstic ,Clinical Biochemistry ,Clinical progression ,RM1-950 ,Somatic evolution in cancer ,Asymptomatic ,Immune system ,Other subheadings::Other subheadings::/immunology [Other subheadings] ,medicine ,Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::Disease Progression [DISEASES] ,Immunologia ,Otros calificadores::Otros calificadores::/inmunología [Otros calificadores] ,T cell exhaustion ,Immune evasion ,Mechanism (biology) ,business.industry ,Research ,Biochemistry (medical) ,Leucèmia ,medicine.disease ,afecciones patológicas, signos y síntomas::procesos patológicos::atributos de la enfermedad::progresión de la enfermedad [ENFERMEDADES] ,medicine.anatomical_structure ,Neoplasms::Neoplasms by Histologic Type::Leukemia::Leukemia, Lymphoid::Leukemia, B-Cell::Leukemia, Lymphocytic, Chronic, B-Cell [DISEASES] ,Cancer research ,Avaluació de resultats (Assistència sanitària) ,Molecular Medicine ,Therapeutics. Pharmacology ,medicine.symptom ,business ,Genètica ,CLL ,Ex vivo ,CD8 ,neoplasias::neoplasias por tipo histológico::leucemia::leucemia linfoide::leucemia de células B::leucemia linfocítica crónica de células B [ENFERMEDADES] - Abstract
Progressió clínica; Evasió immune Progresión clínica; Evasión inmune Clinical progression; Immune evasion Background Mechanisms driving the progression of chronic lymphocytic leukemia (CLL) from its early stages are not fully understood. The acquisition of molecular changes at the time of progression has been observed in a small fraction of patients, suggesting that CLL progression is not mainly driven by dynamic clonal evolution. In order to shed light on mechanisms that lead to CLL progression, we investigated longitudinal changes in both the genetic and immunological scenarios. Methods We performed genetic and immunological longitudinal analysis using paired primary samples from untreated CLL patients that underwent clinical progression (sampling at diagnosis and progression) and from patients with stable disease (sampling at diagnosis and at long-term asymptomatic follow-up). Results Molecular analysis showed limited and non-recurrent molecular changes at progression, indicating that clonal evolution is not the main driver of clinical progression. Our analysis of the immune kinetics found an increasingly dysfunctional CD8+ T cell compartment in progressing patients that was not observed in those patients that remained asymptomatic. Specifically, terminally exhausted effector CD8+ T cells (T-betdim/−EomeshiPD1hi) accumulated, while the the co-expression of inhibitory receptors (PD1, CD244 and CD160) increased, along with an altered gene expression profile in T cells only in those patients that progressed. In addition, malignant cells from patients at clinical progression showed enhanced capacity to induce exhaustion-related markers in CD8+ T cells ex vivo mainly through a mechanism dependent on soluble factors including IL-10. Conclusions Altogether, we demonstrate that the interaction with the immune microenvironment plays a key role in clinical progression in CLL, thereby providing a rationale for the use of early immunotherapeutic intervention. This work was supported by the Instituto de Salud Carlos III, Fondo de Investigaciones Sanitarias (PI17/00950, M.C., PI18/01392, P.A. and PI17/00943, F.B.) and co-financed by the European Regional Development Fund (ERDF) and Fundación Asociación Española Contra el Cáncer (M.C. and P.A.), Gilead Fellowships (GLD16/00144, GLD18/00047, F.B.) and Fundació la Marató de TV3 (201905–30-31 F.B). S.B. is the recipient of a postdoctoral fellowship from Fundación Alfonso Martin Escudero. R.V-M. is supported by a Torres Quevedo fellowship from the Spanish Ministry of Science and Innovation (PTQ-16-08623). A.E-C. is funded by ISCIII/MINECO (PT17/0009/0019) which is co-funded by FEDER. M.C. holds a contract from Ministerio de Ciencia, Innovación y Universidades (RYC-2012-2018).
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- 2021
24. Impact of Heart Rate on Myocardial Salvage in Timely Reperfused Patients with ST-Segment Elevation Myocardial Infarction: New Insights from Cardiovascular Magnetic Resonance.
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Arcari L, Cimino S, De Luca L, Francone M, Galea N, Reali M, Carbone I, Iacoboni C, and Agati L
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- Angioplasty, Balloon, Coronary methods, Coronary Circulation physiology, Electrocardiography methods, Female, Humans, Magnetic Resonance Imaging, Cine methods, Male, Middle Aged, Myocardial Reperfusion methods, Prognosis, Salvage Therapy methods, Time Factors, Heart Rate physiology, Myocardial Infarction pathology, Myocardium pathology
- Abstract
Background: Previous studies evaluating the progression of the necrotic wave in relation to heart rate were carried out only in animal models of ST-elevated myocardial infarction (STEMI). Aim of the study was to investigate changes of myocardial salvage in relation to different heart rates at hospital admission in timely reperfused patients with STEMI by using cardiovascular magnetic resonance (CMR)., Methods: One hundred-eighty-seven patients with STEMI successfully and timely treated with primary coronary angioplasty underwent CMR five days after hospital admission. According to the heart rate at presentation, patients were subcategorized into 5 quintiles: <55 bpm (group I, n = 44), 55-64 bpm (group II, n = 35), 65-74 bpm (group III, n = 35), 75-84 bpm (group IV, n = 37), ≥85 bpm (group V, n = 36). Area at risk, infarct size, microvascular obstruction (MVO) and myocardium salvaged index (MSI) were assessed by CMR using standard sequences., Results: Lower heart rates at presentation were associated with a bigger amount of myocardial salvage after reperfusion. MSI progressively decreased as the heart rates increased (0.54 group I, 0.46 group II, 0.38 group III, 0.34 group IV, 0.32 group V, p<0.001). Stepwise multivariable analysis showed heart rate, peak troponin and the presence of MVO were independent predictor of myocardial salvage. No changes related to heart rate were observed in relation to area at risk and infarct size., Conclusions: High heart rates registered before performing coronary angioplasty in timely reperfused patients with STEMI are associated with a reduction in salvaged myocardium. In particular, salvaged myocardium significantly reduced when heart rate at presentation is ≥85 bpm.
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- 2015
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25. Quantitative analysis of intraventricular blood flow dynamics by echocardiographic particle image velocimetry in patients with acute myocardial infarction at different stages of left ventricular dysfunction.
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Agati L, Cimino S, Tonti G, Cicogna F, Petronilli V, De Luca L, Iacoboni C, and Pedrizzetti G
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- Case-Control Studies, Contrast Media, Echocardiography, Three-Dimensional, Electrocardiography, Female, Humans, Image Interpretation, Computer-Assisted, Male, Middle Aged, Blood Flow Velocity physiology, Echocardiography methods, Myocardial Infarction diagnostic imaging, Myocardial Infarction physiopathology, Ventricular Dysfunction, Left diagnostic imaging, Ventricular Dysfunction, Left physiopathology
- Abstract
Aims: Left ventricular (LV) diastolic filling is characterized by the formation of a vortex that supports an efficient transit into systolic ejection. Aim of this study was to assess the intraventricular (IV) blood flow dynamics among patients with ST elevated myocardial infarction (STEMI) at different degrees of LV dysfunction, in the attempt to find novel indicators of LV pump efficiency., Methods and Results: Sixty-four subjects, 34 consecutive STEMI patients and 30 healthy controls, underwent before hospital discharge 2D speckle tracking echocardiography to assess global longitudinal strain (GLS), and echo-particle image velocimetry analysis to assess flow energetic parameters. Left ventricular volumes ejection fraction (LVEF) and global wall motion score index (GWMSI) were evaluated by 3D echocardiography. ST elevated myocardial infarction patients were subdivided into three groups according to LVEF. Energy dissipation, vorticity fluctuation, and kinetic energy fluctuation indexes, which characterize the degree of disturbance in the flow, exhibit a biphasic behaviour in STEMI patients when compared with controls, with the highest values in patients with still preserved LV function and progressive lower values with LV function worsening. Significant linear correlations were found between energy dissipation index and both LVEF and GLS (r = 0.57, P < 0.001 and r = -0.61, P = 0.001, respectively). Kinetic energy fluctuation index significantly correlates with both LVEF (r = 0.75, P < 0.001) and GLS (-0.58, P = 0.002). Finally, a significant correlation was observed between GWMSI and energy dissipation index (-0.56, P = 0.008)., Conclusions: The present study describes, for the first time, the progression of IV flow energetic properties in patients with acute myocardial infarction at different stages of LV dysfunction when compared with healthy controls. Further data are needed to assess the role of these parameters in the development and maintenance of LV dysfunction., (Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2014. For permissions please email: journals.permissions@oup.com.)
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- 2014
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26. Global and regional longitudinal strain assessed by two-dimensional speckle tracking echocardiography identifies early myocardial dysfunction and transmural extent of myocardial scar in patients with acute ST elevation myocardial infarction and relatively preserved LV function.
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Cimino S, Canali E, Petronilli V, Cicogna F, De Luca L, Francone M, Sardella G, Iacoboni C, and Agati L
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- Cicatrix diagnostic imaging, Cicatrix physiopathology, Contrast Media, Echocardiography, Doppler, Electrocardiography, Female, Humans, Male, Meglumine analogs & derivatives, Middle Aged, Myocardial Infarction therapy, Organometallic Compounds, Risk Factors, Ventricular Dysfunction, Left therapy, Echocardiography methods, Myocardial Infarction diagnostic imaging, Myocardial Infarction physiopathology, Ventricular Dysfunction, Left diagnostic imaging, Ventricular Dysfunction, Left physiopathology
- Abstract
Aims: Global and regional longitudinal strain (GLS-RLS) assessed by two-dimensional speckle tracking echocardiography (2D-STE) are considered reliable indexes of left-ventricular (LV) function and myocardial viability in chronic ischaemic patients when compared with delayed-enhanced cardiac magnetic resonance (DE-CMR). In the present study, we tested whether GLS and RLS could also identify early myocardial dysfunction and transmural extent of myocardial scar in patients with acute ST elevation myocardial infarction (STEMI) and relatively preserved LV function., Methods and Results: Twenty STEMI patients with LVEF ≥40%, treated with PPCI within 6 h from symptoms onset, underwent DE-CMR and 2D-echocardiography for 2D-STE analysis 6 ± 2 days after STEMI. Wall motion score index (WMSI) and LV ejection fraction (LVEF) were calculated by both methods. Infarct size and transmural extent of necrosis were assessed by CMR. GLS and RLS were obtained by 2D-STE. Mean GLS of the study population was -14 ± 3.3, showing a significant correlation with both LVEF and WMSI, by CMR (r = -0.86, P = 0.001, and r = 0.80, P = 0.001, respectively) and time-to-PCI (r = 0.66, P = 0.038). A weaker correlation was found between GLS and LVEF and WMSI assessed by 2D-echo (r = -0.65, P = 0.001, and r = 0.53, P = 0.013, respectively). RLS was significantly lower in DE-segments when compared with normal myocardium (P < 0.0001). A cut-off value of RLS of -12.3% by receiver-operating characteristic (ROC) curves identified DE-segments (sensitivity 82%, specificity 78%), whereas a cut-off value of -11.5% identified transmural extent of DE (sensitivity 75%, specificity 78%)., Conclusion: Our findings indicate that RLS and GLS evaluation provides an accurate assessment of global myocardial function and of the presence of segments with transmural extent of necrosis, with several potential clinical implications.
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- 2013
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27. Degree of residual stenosis of the infarct-related artery. Another variable affecting recovery of regional function after thrombolysis.
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Penco M, Dagianti A Jr, Romano S, Iacoboni C, Vitarelli A, Fedele F, and Dagianti A
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- Adult, Aged, Collateral Circulation drug effects, Collateral Circulation physiology, Female, Humans, Image Processing, Computer-Assisted, Male, Middle Aged, Myocardial Infarction diagnostic imaging, Tissue Plasminogen Activator administration & dosage, Treatment Outcome, Urokinase-Type Plasminogen Activator administration & dosage, Ventricular Function, Left drug effects, Ventricular Function, Left physiology, Coronary Angiography, Myocardial Infarction drug therapy, Thrombolytic Therapy
- Abstract
Aims: The aim of this study was to analyse the relationship between infarct-related artery residual stenosis, assessed by quantitative coronary angiography, and left ventricular function changes during the in-hospital period in patients with acute myocardial infarction undergoing thrombolytic treatment., Methods and Results: The study population consisted of 90 patients with acute myocardial infarction treated with thrombolysis within 6 h of the onset of symptoms. Left ventricular function was serially assessed by an echocardiographic asynergy score (before thrombolysis and pre-discharge). Left ventricular end-diastolic and end-systolic volumes were also calculated. Coronary stenosis was evaluated by computer-assisted videodensitometric analysis at pre-discharge coronary angiography. Three subgroups were identified on the basis of left ventricular function changes: 25 patients (Group A) with regional myocardial improvement (echo score from 7.5 +/- 3.5 to 4.3 +/- 3.2), 51 (Group B) with no variation in echo score (4.8 +/- 2.7) and 14 (Group C) with myocardial regional worsening (echo score from 4.4 +/- 2.1 to 8.8 +/- 2.4). Group A patients exhibited a very high incidence of infarct-related artery patency (23/25 patients, 92%) vs 71% with unchanged (Group B) and 14% (Group C) with worsening regional left ventricular function (P < 0.001). Subdivision of the study population on the basis of residual stenosis severity showed that a significant improvement in left ventricular function was present only in the subgroup with residual stenosis < 75% (echo score from 5.2 +/- 3.4 to 3.6 +/- 2.9, P < 0.001)., Conclusion: These results support the important role exerted by complete coronary patency after thrombolysis in inducing left ventricular function recovery, and the poor functional improvement in patients with incomplete coronary patency.
- Published
- 1998
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28. Influence of residual perfusion within the infarct zone on the natural history of left ventricular dysfunction after acute myocardial infarction: a myocardial contrast echocardiographic study.
- Author
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Agati L, Voci P, Bilotta F, Luongo R, Autore C, Penco M, Iacoboni C, Fedele F, and Dagianti A
- Subjects
- Adult, Aged, Coronary Angiography, Echocardiography methods, Female, Follow-Up Studies, Humans, Male, Middle Aged, Myocardial Contraction, Myocardial Infarction diagnostic imaging, Prognosis, Reproducibility of Results, Serum Albumin, Coronary Circulation, Myocardial Infarction physiopathology, Ventricular Function, Left
- Abstract
Objectives: This study used myocardial contrast echocardiography to investigate the extent of residual perfusion within the infarct zone in a select group of patients with recently reperfused myocardial infarction and evaluated its influence on the ultimate infarct size., Background: Limited information is available on the status of myocardial perfusion within postischemic dysfunctional segments at predischarge and on its influence on late regional and global functional recovery., Methods: Twenty patients with acute myocardial infarction were selected for the study. Patients met the following inclusion criteria: 1) single-vessel coronary artery disease; 2) patency of infarct-related artery with persistent postischemic dysfunctional segments at predischarge; 3) stable clinical condition up to 6 months after hospital discharge. All selected patients underwent coronary angiography and myocardial contrast echocardiography before hospital discharge and repeated the echocardiographic examination 6 months later. Patients were grouped according to the pattern of contrast enhancement in predischarge dysfunctional segments., Results: In nine patients (group I), the length of segments showing abnormal contraction coincided with that of the contrast defect segments. In the remaining 11 patients (group II), postischemic dysfunctional segments were partly or completely reperfused. There was no difference between the two groups in asynergic segment length at predischarge (7.3 +/- 2.5 vs. 7.2 +/- 4.3 cm, p = NS). At follow-up study, asynergic segment length was significantly reduced in group II patients, whereas no changes were observed in group I patients (from 7.2 +/- 4.3 to 4.7 +/- 3.7 cm, p < 0.005; and from 7.3 +/- 2.5 to 7.5 +/- 2.9 cm, p = NS, respectively)., Conclusions: Among patients with a predischarge patent infarct-related artery, further improvement in regional and global function may be expected during follow-up when residual perfusion in the infarct zone is present.
- Published
- 1994
- Full Text
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