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11. The Effect of a Short-Term High-Intensity Circuit Training Program on Work Capacity, Body Composition, and Blood Profiles in Sedentary Obese Men: A Pilot Study

Author

Miller, Matthew B., primary, Pearcey, Gregory E. P., additional, Cahill, Farrell, additional, McCarthy, Heather, additional, Stratton, Shane B. D., additional, Noftall, Jennifer C., additional, Buckle, Steven, additional, Basset, Fabien A., additional, Sun, Guang, additional, and Button, Duane C., additional

Published
2014
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19. Serum metabolic biomarkers distinguish metabolically healthy peripherally obese from unhealthy centrally obese individuals.

Author

Xiang Gao, Weidong Zhang, Yongbo Wang, Pedram, Pardis, Cahill, Farrell, Guangju Zhai, Randell, Edward, Gulliver, Wayne, and Guang Sun

Subjects
ANTHROPOMETRY, BIOMARKERS, BIOCHEMISTRY, BLOOD testing, BODY composition, CHI-squared test, HEALTH status indicators, OBESITY, QUESTIONNAIRES, RESEARCH funding, STATISTICS, T-test (Statistics), DATA analysis, CASE-control method, DATA analysis software, DESCRIPTIVE statistics, ONE-way analysis of variance
Abstract

Background: Metabolic abnormalities are more associated with central obesity than peripheral obesity, but the underlying mechanisms are largely unknown. The present study was to identify serum metabolic biomarkers which distinguish metabolically unhealthy centrally obese (MUCO) from metabolically healthy peripherally obese (MHPO) individuals. Methods: A two-stage case-control study design was employed. In the discovery stage, 20 individuals (10 MHPO and 10 MUCO) were included and in the following validation stage, 79 individuals (20 normal weight (NW), 30 MHPO, 29 MUCO) were utilized. Study groups were matched for age, sex, physical activity and total dietary calorie intake with MHPO and MUCO additionally matched for BMI. Metabolic abnormality was defined as: 1) HOMA-IR>4.27 (90th percentile), 2) high-density lipoprotein cholesterol < 1.03 mmol/L in men and < 1.30 mmol/L in women, 3) fasting blood glucose ≥ 5.6 mmol/L, and 4) waist circumference > 102 cm in men and > 88 cm in women. MUCO individuals had all of these abnormalities whereas MHPO and NW individuals had none of them. A targeted metabolomics approach was performed on fasting serum samples, which can simultaneously identify and quantify 186 metabolites. Results: In the discovery stage, serum leucine, isoleucine, tyrosine, valine, phenylalanine, alpha-aminoadipic acid, methioninesulfoxide and propionylcarnitine were found to be significantly higher in MUCO, compared with MHPO group after multiple testing adjustment. Significant changes of five metabolites (leucine, isoleucine, valine, alpha-aminoadipic acid, propionylcarnitine) were confirmed in the validation stage. Conclusions: Significantly higher levels of serum leucine, isoleucine, valine, alpha-aminoadipic acid, propionylcarnitine are characteristic of metabolically unhealthy centrally obese patients. The finding provides novel insights into the pathogenesis of metabolic abnormalities in obesity. [ABSTRACT FROM AUTHOR]

Published
2016
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