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4. Pediatric Brain Tumors: Signatures from the Intact Proteome

Author

Rossetti, Diana Valeria, primary, Inserra, Ilaria, additional, Nesticò, Alessia, additional, Vincenzoni, Federica, additional, Iavarone, Federica, additional, Messana, Irene, additional, Castagnola, Massimo, additional, Massimi, Luca, additional, Tamburrini, Gianpiero, additional, Caldarelli, Massimo, additional, and Desiderio, Claudia, additional

Published
2022
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6. Diagnosis and treatment of Chiari malformation type 1 in children : the International Consensus Document

Author

Massimi, Luca, Peretta, Paola, Erbetta, Alessandra, Solari, Alessandra, Farinotti, Mariangela, Ciaramitaro, Palma, Saletti, Veronica, Caldarelli, Massimo, Canheu, Alexandre Casagrande, Celada, Carlo, Chiapparini, Luisa, Chieffo, Daniela, Cinalli, Giuseppe, Di Rocco, Federico, Furlanetto, Marika, Giordano, Flavio, Jallo, George, James, Syril, Lanteri, Paola, Lemarchand, Christian, Messing-Jünger, Martina, Parazzini, Cecilia, Paternoster, Giovanna, Piatelli, Gianluca, Poca Pastor, María Antonia, Prabahkar, Prab, Ricci, Federica, Righini, Andrea, Sala, Francesco, Sahuquillo Barris, Juan, Stoodley, Marcus, Talamonti, Giuseppe, Thompson, Dominic, Triulzi, Fabio, Zucchelli, Mino, Valentini, Laura, Universitat Autònoma de Barcelona, Institut Català de la Salut, [Massimi L] Pediatric Neurosurgery, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy. [Peretta P] Pediatric Neurosurgery, AOU Citta’ della Salute e della Scienza di Torino, Torino, Italy. [Erbetta A] Department of Neuroradiology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy. [Solari A, Farinotti M] Neuroepidemiology Unit – Scientific Directorate, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy. [Ciaramitaro P] Department of Neuroscience, AOU Citta’ della Salute e della Scienza di Torino, Torino, Italy. [Poca MA, Sahuquillo J] Unitat de Recerca en Neurotrauma i Neurocirurgia, Servei de Neurocirurgia i Neurocirurgia Pediàtrica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain, and Vall d'Hebron Barcelona Hospital Campus

Subjects
medicine.medical_specialty, Consensus, Delphi Technique, Statement (logic), Craniovertebral decompression, education, Delphi method, personas::Grupos de Edad::niño [DENOMINACIONES DE GRUPOS], Dermatology, Nervous System Diseases::Nervous System Malformations::Neural Tube Defects::Arnold-Chiari Malformation [DISEASES], Malalties - Presa de decisions, Likert scale, 03 medical and health sciences, 0302 clinical medicine, Diagnòstic, enfermedades del sistema nervioso::malformaciones del sistema nervioso::defectos del tubo neural::malformación de Arnold-Chiari [ENFERMEDADES], medicine, Humans, Chiari 1 malformation, Child, Children, Otros calificadores::/terapia [Otros calificadores], Chiari malformation, International network, Consensus conference, Other subheadings::/therapy [Other subheadings], General Medicine, Persons::Age Groups::Child [NAMED GROUPS], medicine.disease, Syringomyelia, Arnold-Chiari Malformation, Management, Psychiatry and Mental health, Patient population, Ciencias de la información::análisis de sistemas::técnica Delfos [CIENCIA DE LA INFORMACIÓN], Italy, Tub neural - Malformacions, 030220 oncology & carcinogenesis, Family medicine, Information Science::Systems Analysis::Delphi Technique [INFORMATION SCIENCE], Original Article, Neurology (clinical), Psychology, Delphi round, 030217 neurology & neurosurgery
Abstract

Background Chiari malformation type 1 (CM1) is a rare condition where agreed classification and treatment are still missing. The goal of this study is to achieve a consensus on the diagnosis and treatment of CM1 in children. Methods A multidisciplinary panel formulated 57 provisional statements based on a review of the literature. Thirty-four international experts (IE) participated in a Delphi study by independently rating each statement on a 4-point Likert scale (“strongly disagree,” “disagree,” “agree,” “strongly agree”). Statements that were endorsed (“agree” or “strongly agree”) by < 75% of raters were re-formulated, or new statements were added, and another Delphi round followed (up to a maximum of three). Results Thirty-five IE were contacted and 34 agreed to participate. A consensus was reached on 30/57 statements (52.6%) after round 1. Three statements were added, and one removed. After round 2, agreement was reached on 56/59 statements (94.9%). Finally, after round 3, which took place during the 2019 Chiari Consensus Conference (Milan, Italy), agreement was reached on 58/59 statements (98.3%) about four main sections (Definition and Classification, Planning, Surgery, Isolated Syringomyelia). Only one statement did not gain a consensus, which is the “definition of radiological failure 24 month post-surgery.” Conclusions The consensus document consists of 58 statements (24 on diagnosis, 34 on treatment), serving clinicians and researchers following children with CM1. There is a clear need for establishing an international network and registry and to promote collaborative studies to increase the evidence base and optimize the long-term care of this patient population.

Published
2021

7. A Cystic Clival Chordoma with CT and MRI Unconventional Appearances.

Author

Guadalupi, Pamela, Gessi, Marco, Massimi, Luca, Caldarelli, Massimo, and Gaudino, Simona

Subjects
GERM cell tumors, MAGNETIC resonance imaging
Abstract

We present the first case of clival cystic chordoma with extradural location, transdural transgression, and moderate bone involvement in a 10-year-old girl. Chordoma showed unconventional appearances on computed tomography (CT) and magnetic resonance imaging (MRI), due to cystic components, extradural space location with extensive intradural extension, moderate superficial bone involvement. Surgery confirmed the extradural location and histopathological examination revealed cystic chordoma. MRI and CT findings were not characteristic for a single lesion; differential diagnoses included cystic lesions such as epidermoid and dermoid cyst, ecchordosis physaliphora, and benign notochordal cell tumors. [ABSTRACT FROM AUTHOR]

Published
2022
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10. 5-YEAR-OLD BOY WITH A CLIVAL MASS

Author

Pettorini, Benedetta Ludovica, Novegno, Federica, Cianfoni, Alessandro, Massimi, Luca, De Bonis, Pasquale, Esposito, Giuseppe, Caldarelli, Massimo, Tamburrini, Gianpiero, Di Rocco, Concezio, Giangaspero, Felice, and Lauriola, Libero

Published
2009
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11. Investigating the Protein Signature of Adamantinomatous Craniopharyngioma Pediatric Brain Tumor Tissue: Towards the Comprehension of Its Aggressive Behavior

Author

Martelli, Claudia, primary, Serra, Riccardo, additional, Inserra, Ilaria, additional, Rossetti, Diana Valeria, additional, Iavarone, Federica, additional, Vincenzoni, Federica, additional, Castagnola, Massimo, additional, Urbani, Andrea, additional, Tamburrini, Gianpiero, additional, Caldarelli, Massimo, additional, Massimi, Luca, additional, and Desiderio, Claudia, additional

Published
2019
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12. EPEN-03. PEDIATRIC INTRACRANIAL EPENDYMOMA: CORRELATION OF SYMPTOMS AND SIGNS AT RECURRENCE WITH OUTCOME IN THE SECOND PROSPECTIVE AIEOP PROTOCOL FOLLOW-UP

Author

Massimino, Maura, primary, Barretta, Francesco, additional, Giangaspero, Felice, additional, Chiapparini, Luisa, additional, Erbetta, Alessandra, additional, Boschetti, Luna, additional, Modena, Piergiorgio, additional, Antonelli, Manila, additional, Ferroli, Paolo, additional, Bertin, Daniele, additional, Pecori, Emilia, additional, Biassoni, Veronica, additional, Garrè, Maria Luisa, additional, Schiavello, Elisabetta, additional, Sardi, Iacopo, additional, Viscardi, Elisabetta, additional, Scarzello, Giovanni, additional, Mascarin, Maurizio, additional, Quaglietta, Lucia, additional, Cinalli, Giuseppe, additional, Genitori, Lorenzo, additional, Peretta, Paola, additional, Mussano, Anna, additional, Barra, Salvina, additional, Mastronuzzi, Angela, additional, Giussani, Carlo, additional, Marras, Carlo Efisio, additional, Balter, Rita, additional, Bertolini, Patrizia, additional, Tornesello, Assunta, additional, Spina, Milena La, additional, Buttarelli, Francesca Romana, additional, Ruggiero, Antonio, additional, Caldarelli, Massimo, additional, Poggi, Geraldina, additional, and Gandola, Lorenza, additional

Published
2018
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13. Novel SEC61G–EGFR Fusion Gene in Pediatric Ependymomas Discovered by Clonal Expansion of Stem Cells in Absence of Exogenous Mitogens

Author

Servidei, Tiziana, primary, Meco, Daniela, additional, Muto, Valentina, additional, Bruselles, Alessandro, additional, Ciolfi, Andrea, additional, Trivieri, Nadia, additional, Lucchini, Matteo, additional, Morosetti, Roberta, additional, Mirabella, Massimiliano, additional, Martini, Maurizio, additional, Caldarelli, Massimo, additional, Lasorella, Anna, additional, Tartaglia, Marco, additional, and Riccardi, Riccardo, additional

Published
2017
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14. Intracystic interferon-alpha in pediatric craniopharyngioma patients: an international multicenter assessment on behalf of SIOPE and ISPN

Author

Kilday, John-Paul, primary, Caldarelli, Massimo, additional, Massimi, Luca, additional, Chen, Robert Hsin-Hung, additional, Lee, Yi Yen, additional, Liang, Muh-Lii, additional, Parkes, Jeanette, additional, Naiker, Thuran, additional, van Veelen, Marie-Lise, additional, Michiels, Erna, additional, Mallucci, Conor, additional, Pettorini, Benedetta, additional, Meijer, Lisethe, additional, Dorfer, Christian, additional, Czech, Thomas, additional, Diezi, Manuel, additional, Schouten-van Meeteren, Antoinette YN, additional, Holm, Stefan, additional, Gustavsson, Bengt, additional, Benesch, Martin, additional, Müller, Hermann L, additional, Hoffmann, Anika, additional, Rutkowski, Stefan, additional, Flitsch, Joerg, additional, Escherich, Gabriele, additional, Grotzer, Michael, additional, Spoudeas, Helen A, additional, Azquikina, Kristian, additional, Capra, Michael, additional, Jiménez-Guerra, Rolando, additional, MacDonald, Patrick, additional, Johnston, Donna L, additional, Dvir, Rina, additional, Constantini, Shlomi, additional, Kuo, Meng-Fai, additional, Yang, Shih-Hung, additional, and Bartels, Ute, additional

Published
2017
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