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2023 JUN 15 (NewsRx) -- By a News Reporter-Staff News Editor at Women's Health Weekly -- Investigators publish new report on preventive cardiology. According to news reporting originating from Masaryk [...]

2020 SEP 28 (NewsRx) -- By a News Reporter-Staff News Editor at Stem Cell Week -- Investigators discuss new findings in Stem Cell Research - Pluripotent Stem Cells. According to [...]

In the world of cardiology, wisdom holds that 'seconds are cells, and minutes are muscle,' and that one of the best methods for improving patient outcomes is to improve efficiency [...]

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.jtcvs.2009.04.005 Byline: Takayuki Ohno (a), Osamu Kinoshita (a), Hideo Fujita (b), Satoshi Kato (c), Akira Hirose (c), Takashi Sigeeda (c), Kazuyoshi Otomo (c), Jiro Ando (b), Takashi Kadowaki (d), Makoto Araie (c), Ryozo Nagai (b), Shinichi Takamoto (a) Abbreviations: CABG, coronary artery bypass grafting; CAD, coronary artery disease; CT, computed tomography; DES, drug-eluting stent; DR, diabetic retinopathy; ECG, electrocardiography; ETT, exercise treadmill test; LAD, left anterior descending coronary artery; LMT, left main trunk; NPDR, nonproliferative diabetic retinopathy; PCI, percutaneous coronary intervention; PDR, proliferative diabetic retinopathy Abstract: We hypothesized that a large number of patients with diabetic retinopathy who could benefit greatly from early coronary artery bypass grafting would not be identified. Author Affiliation: (a) Department of Cardiothoracic Surgery, University of Tokyo, Tokyo, Japan (b) Department of Cardiology, University of Tokyo, Tokyo, Japan (c) Department of Ophthalmology, University of Tokyo, Tokyo, Japan (d) Department of Endocrinology and Metabolism, University of Tokyo, Tokyo, Japan Article History: Received 30 November 2008; Revised 19 March 2009; Accepted 1 April 2009

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.jtcvs.2009.05.023 Byline: Yuan Bai (a), Gang-Jun Zong (c), Hai-Bing Jiang (a), Wei-Ping Li (b), Hong Wu (a), Xian-Xian Zhao (a), Yong-Wen Qin (a) Abstract: Percutaneous pulmonary valve replacement has been recently introduced into clinical practice. Patients with transcatheter pulmonary valve replacement will definitely face the problems of valve degeneration. In addition to surgical re-replacement of the degenerated bioprosthetic valves, we studied the replacement of degenerated bioprosthetic valves with transcatheter reimplantation of stent-mounted pulmonary valves. Author Affiliation: (a) Department of Cardiology, Changhai Hospital, the Second Military Medical University, Shanghai, China (b) Department of Ultrasonography, Changhai Hospital, the Second Military Medical University, Shanghai, China (c) Department of Cardiology, 101 Hospital of PLA, Wuxi, Jiangsu Province, China Article History: Received 19 February 2009; Revised 24 April 2009; Accepted 18 May 2009 Article Note: (footnote) Y. Bai and G.-J. Zong contributed equally to this study., This study was supported by National High-Tech R and D Program of China ('863' Program) (2006AA02Z4D7)., Disclosures: There is no conflict of interest in this study.

Byline: Flemming Randsbaek, Hans-Henrik Kimose, Thomas Bjerre, Ulla MA[cedilla]ldrup, Hans Erik BA[cedilla]tker, Torsten Toftegaard Nielsen Abstract: Objective: We sought to evaluate the effects of captopril on glucose-related metabolism during hypothermic cardioplegic storage and subsequent reperfusion. Methods: We compared hearts from control pigs with hearts from pigs treated with increasing oral doses of captopril for 3 weeks (12.5-150 mg daily), an intravenous bolus (25 mg) before operation, and captopril-containing cardioplegic solution (1 mg/L). The hearts were excised after infusion of cold crystalloid cardioplegic solution and stored in saline solution (4[degrees]C-6[degrees]C). In one series we studied myocardial blood flow and arteriovenous differences in oxygen, glucose, lactate, glutamate, and alanine during 60 minutes of postcardioplegic blood reperfusion. In this series captopril-treated hearts were reperfused with captopril-containing blood (1 mg/L). In another series we obtained biopsy specimens from the left ventricle throughout 30 hours of hypothermic cardioplegic storage and monitored tissue content of energy-rich phosphates, glycogen, glutamate, and alanine. Results: Captopril increased glutamate and alanine release 11- to 17-fold at the start of reperfusion (P < .001). Furthermore, captopril increased myocardial oxygen and glucose uptake during reperfusion (P < .001 for both), whereas lactate release and myocardial blood flow were unaffected by captopril. At the start of reperfusion, there was a positive correlation between glutamate release and glucose uptake in captopril-treated hearts (r = 0.66, P = .05). We found no statistically significant differences between captopril and control hearts in tissue content of adenosine triphosphate, glycogen, glutamate, alanine, or lactate during 30 hours of cardioplegic storage. Conclusions: The metabolic effects of captopril are strictly related to reperfusion, during which oxidative metabolism of glucose is improved. The captopril-induced increase in glutamate and alanine release at the start of reperfusion after cardioplegic storage may reflect a switch in metabolism of glucose-related amino acids. (J Thorac Cardiovasc Surg 2000;119:1030-8) Author Affiliation: Department of Cardiology and Institute of Experimental Clinical Research, Skejby Hospital, Aarhus University Hospitals, University of Aarhus, Denmark Article History: Received 30 June 1999; Revised 16 September 1999; Revised 8 November 1999; Accepted 6 December 1999 Article Note: (footnote) [star] Supported by the Danish Health Research Council, grant No. 9600822 (Aarhus University, Novo Nordisk Centre for Research in Growth and Regeneration)., [star][star] Address for reprints: Flemming RandsbA[bar]k, MD, Department of Cardiology, Skejby Hospital, Aarhus University Hospitals, Brendstrupgaardvej, 8200 Aarhus N, Denmark.