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5. Endoscopic Ultrasound-Guided Fine Needle Biopsy of Focal Liver Lesions: An Effective Mini-Invasive Alternative to the Percutaneous Approach.

Author

Rancatore, Gabriele, Ligresti, Dario, Rizzo, Giacomo Emanuele Maria, Carrozza, Lucio, Traina, Mario, and Tarantino, Ilaria

Subjects
ENDOSCOPIC ultrasonography, NEEDLE biopsy, ROUTE choice, LIVER biopsy, COMPUTED tomography
Abstract

Despite the introduction of serological neoplastic biomarkers and typical radiological characteristics in clinical practice, liver biopsy (LB) is often still necessary to establish a histological diagnosis, especially in ambiguous cases. Nowadays, LB via the percutaneous approach (PC-LB), under computed tomography (CT) scan or ultrasonography (US) guidance, is the route of choice. However, certain focal liver lesions can be challenging to access percutaneously. In such cases, endoscopic ultrasound (EUS)-guided fine needle biopsy (FNB) may represent an attractive, minimally invasive alternative. This retrospective observational study aimed to evaluate the efficacy, diagnostic performance, and safety of EUS-FNB conducted on 58 focal liver lesions located in both liver lobes. The adequacy of FNB samples for focal liver lesions located in the left and right lobes was 100% and 81.2%, respectively, and the difference was statistically significant (p = 0.001). Technical success was 100% for both liver lobes. The overall sensitivity and specificity were 95% and 100%, respectively. EUS-FNB is effective in making an accurate diagnosis with an excellent safety profile for focal liver lesions located in both liver lobes. [ABSTRACT FROM AUTHOR]

Published
2024
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7. SARS-CoV-2 infection in patients with inflammatory bowel disease: comparison between the first and second pandemic waves

Author

Bezzio, Cristina, Vernero, Marta, Costa, Stefania, Armuzzi, Alessandro, Fiorino, Gionata, Ardizzone, Sandro, Roselli, Jenny, Carparelli, Sonia, Orlando, Ambrogio, Caprioli, Flavio Andrea, Castiglione, Fabiana, Viganò, Chiara, Ribaldone, Davide G., Zingone, Fabiana, Monterubbianesi, Rita, Imperatore, Nicola, Festa, Stefano, Daperno, Marco, Scucchi, Ludovica, Ferronato, Antonio, Pastorelli, Luca, Alimenti, Eleonora, Balestrieri, Paola, Ricci, Chiara, Cappello, Maria, Felice, Carla, Coppini, Francesca, Alvisi, Patrizia, Di Luna, Imma, Gerardi, Viviana, Variola, Angela, Mazzuoli, Silvia, Lenti, Marco Vincenzo, Saibeni, Simone, Pugliese, Daniela, Furfaro, Federica, Maconi, Giovanni, Milla, Monica, Bossa, Fabrizio, Giuliano, Alessandra, Piazza, Nicole, Manes, Gianpiero, Sartini, Alessandro, Buda, Andrea, Micheli, Federica, Ciardo, Valeria, Casella, Giovanni, Viscido, Angelo, Bodini, Giorgia, Casini, Valentina, Soriano, Alessandra, Amato, Arnaldo, Grossi, Laurino, Onali, Sara, Rottoli, Matteo, Spagnuolo, Rocco, Baroni, Stefania, Cortelezzi, Claudio, Baldoni, Monia, Scaldaferri, Franco, Guarino, Alessia, Palermo, Andrea, D’Incà, Renata, Scribano, Maria Lia, Biancone, Livia, Carrozza, Lucio, Ascolani, Marta, Costa, Francesco, Di Sabatino, Antonio, Zammarchi, Irene, Gottin, Matteo, Conforti, Francesco Simone, Null, Null, Armuzzi, Alessandro (ORCID:0000-0003-1572-0118), Scaldaferri, Franco (ORCID:0000-0001-8334-7541), Bezzio, Cristina, Vernero, Marta, Costa, Stefania, Armuzzi, Alessandro, Fiorino, Gionata, Ardizzone, Sandro, Roselli, Jenny, Carparelli, Sonia, Orlando, Ambrogio, Caprioli, Flavio Andrea, Castiglione, Fabiana, Viganò, Chiara, Ribaldone, Davide G., Zingone, Fabiana, Monterubbianesi, Rita, Imperatore, Nicola, Festa, Stefano, Daperno, Marco, Scucchi, Ludovica, Ferronato, Antonio, Pastorelli, Luca, Alimenti, Eleonora, Balestrieri, Paola, Ricci, Chiara, Cappello, Maria, Felice, Carla, Coppini, Francesca, Alvisi, Patrizia, Di Luna, Imma, Gerardi, Viviana, Variola, Angela, Mazzuoli, Silvia, Lenti, Marco Vincenzo, Saibeni, Simone, Pugliese, Daniela, Furfaro, Federica, Maconi, Giovanni, Milla, Monica, Bossa, Fabrizio, Giuliano, Alessandra, Piazza, Nicole, Manes, Gianpiero, Sartini, Alessandro, Buda, Andrea, Micheli, Federica, Ciardo, Valeria, Casella, Giovanni, Viscido, Angelo, Bodini, Giorgia, Casini, Valentina, Soriano, Alessandra, Amato, Arnaldo, Grossi, Laurino, Onali, Sara, Rottoli, Matteo, Spagnuolo, Rocco, Baroni, Stefania, Cortelezzi, Claudio, Baldoni, Monia, Scaldaferri, Franco, Guarino, Alessia, Palermo, Andrea, D’Incà, Renata, Scribano, Maria Lia, Biancone, Livia, Carrozza, Lucio, Ascolani, Marta, Costa, Francesco, Di Sabatino, Antonio, Zammarchi, Irene, Gottin, Matteo, Conforti, Francesco Simone, Null, Null, Armuzzi, Alessandro (ORCID:0000-0003-1572-0118), and Scaldaferri, Franco (ORCID:0000-0001-8334-7541)

Abstract

BackgroundIn Italy, the incidence of SARS-CoV-2 infection peaked in April and November 2020, defining two pandemic waves of coronavirus disease 2019 (COVID-19). This study compared the characteristics and outcomes of patients with inflammatory bowel disease (IBD) and SARS-CoV-2 infections between pandemic waves.MethodsObservational longitudinal study of IBD patients with SARS-CoV-2 infection. Patients with established diagnoses of IBD and of SARS-CoV-2 infection were consecutively enrolled in two periods: (i) first wave, from 1 March 2020 to 31 May 2020; and (ii) second wave, from 15 September to 15 December 2020.ResultsWe enrolled 937 IBD patients (219 in the first wave, 718 in the second wave). Patients of the first wave were older (mean & PLUSMN; SD: 46.3 & PLUSMN; 16.2 vs. 44.1 & PLUSMN; 15.4 years, p = 0.06), more likely to have ulcerative colitis (58.0% vs. 44.4%, p < 0.001) and comorbidities (48.9% vs. 38.9%; p < 0.01), and more frequently residing in Northern Italy (73.1% vs. 46.0%, p < 0.001) than patients of the second wave. There were no significant differences between pandemic waves in sex (male: 54.3% vs. 53.3%, p = 0.82) or frequency of active IBD (44.3% vs. 39.0%, p = 0.18). The rates of negative outcomes were significantly higher in the first than second wave: pneumonia (27.8% vs. 11.7%, p < 0.001), hospital admission (27.4% vs. 9.7%, p < 0.001), ventilatory support (11.9% vs. 5.4%, p < 0.003) and death (5.5% vs. 1.8%, p < 0.007).ConclusionBetween the first and second SARS-CoV-2 pandemic waves, demographic, clinical and geographical features of IBD patients were different as were the symptoms and outcomes of infection. These differences are likely due to the different epidemiological situations and diagnostic possibilities between the two waves.

Published
2023

9. Telemedicine Is an Effective Tool to Monitor Disease Activity in IBD Patients in the COVID-19 Era: A Single Centre Experience Based on Objective Data

Author

Sinagra, Emanuele, primary, Busacca, Anita, additional, Guida, Laura, additional, Carrozza, Lucio, additional, Brinch, Daniele, additional, Crispino, Federica, additional, Maida, Marcello, additional, Battaglia, Salvatore, additional, Celsa, Ciro, additional, Cammà, Calogero, additional, and Cappello, Maria, additional

Published
2022
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