190 results on '"Carsin, Anne‐Elie"'
Search Results
2. Mobilise-D insights to estimate real-world walking speed in multiple conditions with a wearable device
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Kirk, Cameron, Küderle, Arne, Micó-Amigo, M. Encarna, Bonci, Tecla, Paraschiv-Ionescu, Anisoara, Ullrich, Martin, Soltani, Abolfazl, Gazit, Eran, Salis, Francesca, Alcock, Lisa, Aminian, Kamiar, Becker, Clemens, Bertuletti, Stefano, Brown, Philip, Buckley, Ellen, Cantu, Alma, Carsin, Anne-Elie, Caruso, Marco, Caulfield, Brian, Cereatti, Andrea, Chiari, Lorenzo, D’Ascanio, Ilaria, Garcia-Aymerich, Judith, Hansen, Clint, Hausdorff, Jeffrey M., Hiden, Hugo, Hume, Emily, Keogh, Alison, Kluge, Felix, Koch, Sarah, Maetzler, Walter, Megaritis, Dimitrios, Mueller, Arne, Niessen, Martijn, Palmerini, Luca, Schwickert, Lars, Scott, Kirsty, Sharrack, Basil, Sillén, Henrik, Singleton, David, Vereijken, Beatrix, Vogiatzis, Ioannis, Yarnall, Alison J., Rochester, Lynn, Mazzà, Claudia, Eskofier, Bjoern M., and Del Din, Silvia
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- 2024
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3. Assessing real-world gait with digital technology? Validation, insights and recommendations from the Mobilise-D consortium
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Micó-Amigo, M. Encarna, Bonci, Tecla, Paraschiv-Ionescu, Anisoara, Ullrich, Martin, Kirk, Cameron, Soltani, Abolfazl, Küderle, Arne, Gazit, Eran, Salis, Francesca, Alcock, Lisa, Aminian, Kamiar, Becker, Clemens, Bertuletti, Stefano, Brown, Philip, Buckley, Ellen, Cantu, Alma, Carsin, Anne-Elie, Caruso, Marco, Caulfield, Brian, Cereatti, Andrea, Chiari, Lorenzo, D’Ascanio, Ilaria, Eskofier, Bjoern, Fernstad, Sara, Froehlich, Marcel, Garcia-Aymerich, Judith, Hansen, Clint, Hausdorff, Jeffrey M., Hiden, Hugo, Hume, Emily, Keogh, Alison, Kluge, Felix, Koch, Sarah, Maetzler, Walter, Megaritis, Dimitrios, Mueller, Arne, Niessen, Martijn, Palmerini, Luca, Schwickert, Lars, Scott, Kirsty, Sharrack, Basil, Sillén, Henrik, Singleton, David, Vereijken, Beatrix, Vogiatzis, Ioannis, Yarnall, Alison J., Rochester, Lynn, Mazzà, Claudia, and Del Din, Silvia
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- 2023
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4. Early life exposures contributing to accelerated lung function decline in adulthood – a follow-up study of 11,000 adults from the general population
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Kirkeleit, Jorunn, Riise, Trond, Wielscher, Mathias, Accordini, Simone, Carsin, Anne-Elie, Dratva, Julie, Franklin, Karl A., Garcia-Aymerich, Judith, Jarvis, Deborah, Leynaert, Benedicte, Lodge, Caroline J., Real, Francisco Gomez, Schlünssen, Vivi, Corsico, Angelo Guido, Heinrich, Joachim, Holm, Matthias, Janson, Christer, Benediktsdóttir, Bryndis, Jogi, Rain, Dharmage, Shyamali C., Järvelin, Marjo-Riitta, and Svanes, Cecilie
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- 2023
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5. Urban environment and physical activity and capacity in patients with chronic obstructive pulmonary disease
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Koreny, Maria, Arbillaga-Etxarri, Ane, Bosch de Basea, Magda, Foraster, Maria, Carsin, Anne-Elie, Cirach, Marta, Gimeno-Santos, Elena, Barberan-Garcia, Anael, Nieuwenhuijsen, Mark, Vall-Casas, Pere, Rodriguez-Roisín, Robert, and Garcia-Aymerich, Judith
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- 2022
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6. Multisite greenness exposure and oxidative stress in children. The potential mediating role of physical activity
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Squillacioti, Giulia, Carsin, Anne-Elie, Bellisario, Valeria, Bono, Roberto, and Garcia-Aymerich, Judith
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- 2022
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7. Higher mortality and intubation rate in COVID-19 patients treated with noninvasive ventilation compared with high-flow oxygen or CPAP
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Marti, Sergi, Carsin, Anne-Elie, Sampol, Júlia, Pallero, Mercedes, Aldas, Irene, Marin, Toni, Lujan, Manel, Lalmolda, Cristina, Sabater, Gladis, Bonnin-Vilaplana, Marc, Peñacoba, Patricia, Martinez-Llorens, Juana, Tárrega, Julia, Bernadich, Óscar, Córdoba-Izquierdo, Ana, Lozano, Lourdes, Mendez, Susana, Vélez-Segovia, Eduardo, Prina, Elena, Eizaguirre, Saioa, Balañá-Corberó, Ana, Ferrer, Jaume, and Garcia-Aymerich, Judith
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- 2022
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8. Design and validation of a multi-task, multi-context protocol for real-world gait simulation
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Scott, Kirsty, Bonci, Tecla, Salis, Francesca, Alcock, Lisa, Buckley, Ellen, Gazit, Eran, Hansen, Clint, Schwickert, Lars, Aminian, Kamiar, Bertuletti, Stefano, Caruso, Marco, Chiari, Lorenzo, Sharrack, Basil, Maetzler, Walter, Becker, Clemens, Hausdorff, Jeffrey M., Vogiatzis, Ioannis, Brown, Philip, Del Din, Silvia, Eskofier, Björn, Paraschiv-Ionescu, Anisoara, Keogh, Alison, Kirk, Cameron, Kluge, Felix, Micó-Amigo, Encarna M., Mueller, Arne, Neatrour, Isabel, Niessen, Martijn, Palmerini, Luca, Sillen, Henrik, Singleton, David, Ullrich, Martin, Vereijken, Beatrix, Froehlich, Marcel, Brittain, Gavin, Caulfield, Brian, Koch, Sarah, Carsin, Anne-Elie, Garcia-Aymerich, Judith, Kuederle, Arne, Yarnall, Alison, Rochester, Lynn, Cereatti, Andrea, and Mazzà, Claudia
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- 2022
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9. Ecological validity of a deep learning algorithm to detect gait events from real-life walking bouts in mobility-limiting diseases
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Romijnders, Robbin, primary, Salis, Francesca, additional, Hansen, Clint, additional, Küderle, Arne, additional, Paraschiv-Ionescu, Anisoara, additional, Cereatti, Andrea, additional, Alcock, Lisa, additional, Aminian, Kamiar, additional, Becker, Clemens, additional, Bertuletti, Stefano, additional, Bonci, Tecla, additional, Brown, Philip, additional, Buckley, Ellen, additional, Cantu, Alma, additional, Carsin, Anne-Elie, additional, Caruso, Marco, additional, Caulfield, Brian, additional, Chiari, Lorenzo, additional, D'Ascanio, Ilaria, additional, Del Din, Silvia, additional, Eskofier, Björn, additional, Fernstad, Sara Johansson, additional, Fröhlich, Marceli Stanislaw, additional, Garcia Aymerich, Judith, additional, Gazit, Eran, additional, Hausdorff, Jeffrey M., additional, Hiden, Hugo, additional, Hume, Emily, additional, Keogh, Alison, additional, Kirk, Cameron, additional, Kluge, Felix, additional, Koch, Sarah, additional, Mazzà, Claudia, additional, Megaritis, Dimitrios, additional, Micó-Amigo, Encarna, additional, Müller, Arne, additional, Palmerini, Luca, additional, Rochester, Lynn, additional, Schwickert, Lars, additional, Scott, Kirsty, additional, Sharrack, Basil, additional, Singleton, David, additional, Soltani, Abolfazl, additional, Ullrich, Martin, additional, Vereijken, Beatrix, additional, Vogiatzis, Ioannis, additional, Yarnall, Alison, additional, Schmidt, Gerhard, additional, and Maetzler, Walter, additional
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- 2023
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10. Restrictive spirometry pattern is associated with low physical activity levels. A population based international study
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Carsin, Anne-Elie, Fuertes, Elaine, Schaffner, Emmanuel, Jarvis, Debbie, Antó, Josep M., Heinrich, Joachim, Bellisario, Valeria, Svanes, Cecilie, Keidel, Dirk, Imboden, Medea, Weyler, Joost, Nowak, Dennis, Martinez-Moratalla, Jesus, Gullón, José-Antonio, Sanchez Ramos, José Luis, Caviezel, Seraina, Beckmeyer-Borowko, Anna, Raherison, Chantal, Pin, Isabelle, Demoly, Pascal, Cerveri, Isa, Accordini, Simone, Gislason, Thorarinn, Toren, Kjell, Forsberg, Bertil, Janson, Christer, Jogi, Rain, Emtner, Margareta, Gómez Real, Francisco, Raza, Wasif, Leynaert, Bénédicte, Pascual, Silvia, Guerra, Stefano, Dharmage, Shyamali C., Probst-Hensch, Nicole, and Garcia-Aymerich, Judith
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- 2019
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11. Incidence trends of airflow obstruction among European adults without asthma: a 20-year cohort study
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Accordini, Simone, Calciano, Lucia, Marcon, Alessandro, Pesce, Giancarlo, Antó, Josep M., Beckmeyer-Borowko, Anna B., Carsin, Anne-Elie, Corsico, Angelo G., Imboden, Medea, Janson, Christer, Keidel, Dirk, Locatelli, Francesca, Svanes, Cecilie, Burney, Peter G. J., Jarvis, Deborah, Probst-Hensch, Nicole M., and Minelli, Cosetta
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- 2020
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12. Gestational phthalate exposure and lung function during childhood: A prospective population-based study
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Bosch de Basea, Magda, primary, Carsin, Anne-Elie, additional, Abellan, Alicia, additional, Cobo, Inés, additional, Lertxundi, Aitana, additional, Marin, Natalia, additional, Soler-Blasco, Raquel, additional, Ibarluzea, Jesús, additional, Vrijheid, Martine, additional, Sunyer, Jordi, additional, Casas, Maribel, additional, and Garcia-Aymerich, Judith, additional
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- 2022
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13. Creatine Kinase is Decreased in Childhood Asthma
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Guerra, Stefano, primary, Ledford, Julie G., additional, Melén, Erik, additional, Lavi, Iris, additional, Carsin, Anne-Elie, additional, Stern, Debra A, additional, Zhai, Jing, additional, Vidal, Marta, additional, Bustamante, Mariona, additional, Addison, Kenneth J., additional, Vallecillo, Renata G., additional, Billheimer, Dean, additional, Koppelman, Gerard H, additional, Garcia-Aymerich, Judith, additional, Lemonnier, Nathanaël, additional, Fitó, Montserrat, additional, Dobaño, Carlota, additional, Kebede Merid, Simon, additional, Kull, Inger, additional, McEachan, Rosemary R C, additional, Wright, John, additional, Chatzi, Leda, additional, Kogevinas, Manolis, additional, Porta, Daniela, additional, Narduzzi, Silvia, additional, Ballester, Ferran, additional, Esplugues, Ana, additional, Zabaleta, Carlos, additional, Irizar, Amaia, additional, Sunyer, Jordi, additional, Halonen, Marilyn, additional, Bousquet, Jean, additional, Martinez, Fernando D, additional, and Anto, Josep M., additional
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- 2022
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14. The relation of circulating YKL-40 to levels and decline of lung function in adult life
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Guerra, Stefano, Halonen, Marilyn, Sherrill, Duane L., Venker, Claire, Spangenberg, Amber, Carsin, Anne-elie, Tarès, Lluïsa, Lavi, Iris, Barreiro, Esther, Martínez-Moratalla, Jesús, Urrutia, Isabel, Sunyer, Jordi, Antó, Josep M., and Martinez, Fernando D.
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- 2013
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15. Polybrominated Diphenyl Ethers (PBDEs) in Breast Milk and Neuropsychological Development in Infants
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Gascon, Mireia, Fort, Marta, Martínez, David, Carsin, Anne-Elie, Forns, Joan, Grimalt, Joan O., Marina, Loreto Santa, Lertxundi, Nerea, Sunyer, Jordi, and Vrijheid, Martine
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- 2012
16. Creatine Kinase Is Decreased in Childhood Asthma.
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Guerra, Stefano, Ledford, Julie G., Melén, Erik, Lavi, Iris, Carsin, Anne-Elie, Stern, Debra A., Zhai, Jing, Vidal, Marta, Bustamante, Mariona, Addison, Kenneth J., Vallecillo, Renata G., Billheimer, Dean, Koppelman, Gerard H., Garcia-Aymerich, Judith, Lemonnier, Nathanaël, Fitó, Montserrat, Dobaño, Carlota, Merid, Simon Kebede, Kull, Inger, and McEachan, Rosemary R. C.
- Abstract
The article offers several studies that have assessed various protein panels in asthma with most using airway-derived samples, recruiting clinic-based cohorts and focuses on cytokines and chemokines. Topics include examines there is a lack of large-scale population-based studies that examine multiple circulating proteins for association with asthma in children.
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- 2023
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17. Higher mortality and intubation rate in COVID-19 patients treated with noninvasive ventilation compared with high-flow oxygen or CPAP
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Marti, Sergi, Carsin, Anne-Elie, Sampol, Júlia, Pallero, Mercedes, Aldas Criado, Irene, Marin, Toni, Luján, Manel, Lalmolda, Cristina, Sabater, Gladis, Bonnin-Vilaplana, Marc, Peñacoba, Patricia, Martinez-Llorens, Juana, Tárrega, Julia, Bernadich, Óscar, Córdoba-Izquierdo, Ana, Lozano, Lourdes, Mendez, Susana, Vélez-Segovia, Eduardo, Prina, Elena, Eizaguirre, Saioa, Balañá Corberó, Ana, Ferrer Sancho, Jaume, Garcia-Aymerich, J., Universitat Autònoma de Barcelona, [Marti S, Sampol J, Pallero M, Ferrer J] Servei de Pneumologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. CIBER de Enfermedades Respiratorias (CIBERES), Madrid, Spain. [Carsin AE] ISGlobal, Barcelona, Spain. Universitat Pompeu Fabra (UPF), Barcelona, Spain. CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain. [Aldas I, Marin T] Respiratory Department, Hospital Universitari Germans Trias i Pujol, Badalona, Spain. [Tárrega J] Respiratory Department, Hospital General de Granollers, Granollers, Spain. Universitat Internacional de Catalunya, Barcelona, Spain. [Vélez Segovia E] Servei de Pneumologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain, and Hospital General de Granollers
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Multidisciplinary ,Noninvasive Ventilation ,Respiratory distress syndrome ,Continuous Positive Airway Pressure ,Therapeutics::Airway Management::Intubation, Intratracheal [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT] ,terapéutica::manejo de la via aérea::respiración artificial::ventilación no invasiva [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS] ,COVID-19 ,Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections [DISEASES] ,Terapèutica ,COVID-19 (Malaltia) ,Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections::Severe Acute Respiratory Syndrome [DISEASES] ,Oxygen ,terapéutica::manejo de la via aérea::intubación endotraqueal [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS] ,Insuficiència respiratòria ,virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por Coronavirus::síndrome respiratorio agudo grave [ENFERMEDADES] ,virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por Coronavirus [ENFERMEDADES] ,Intubation, Intratracheal ,Infectious diseases ,Humans ,Therapeutics::Airway Management::Respiration, Artificial::Noninvasive Ventilation [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT] ,Respiratory insufficiency ,Respiratory Insufficiency - Abstract
COVID-19; Noninvasive ventilation; High-flow oxygen COVID-19; Ventilación no invasiva; Oxígeno de alto flujo COVID-19; Ventilació no invasiva; Oxigen d'alt cabal The effectiveness of noninvasive respiratory support in severe COVID-19 patients is still controversial. We aimed to compare the outcome of patients with COVID-19 pneumonia and hypoxemic respiratory failure treated with high-flow oxygen administered via nasal cannula (HFNC), continuous positive airway pressure (CPAP) or noninvasive ventilation (NIV), initiated outside the intensive care unit (ICU) in 10 university hospitals in Catalonia, Spain. We recruited 367 consecutive patients aged ≥ 18 years who were treated with HFNC (155, 42.2%), CPAP (133, 36.2%) or NIV (79, 21.5%). The main outcome was intubation or death at 28 days after respiratory support initiation. After adjusting for relevant covariates and taking patients treated with HFNC as reference, treatment with NIV showed a higher risk of intubation or death (hazard ratio 2.01; 95% confidence interval 1.32-3.08), while treatment with CPAP did not show differences (0.97; 0.63-1.50). In the context of the pandemic and outside the intensive care unit setting, noninvasive ventilation for the treatment of moderate to severe hypoxemic acute respiratory failure secondary to COVID-19 resulted in higher mortality or intubation rate at 28 days than high-flow oxygen or CPAP. This finding may help physicians to choose the best noninvasive respiratory support treatment in these patients.Clinicaltrials.gov identifier: NCT04668196.
- Published
- 2021
18. Technical validation of real-world monitoring of gait: a multicentric observational study
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Mazzà, Claudia, primary, Alcock, Lisa, additional, Aminian, Kamiar, additional, Becker, Clemens, additional, Bertuletti, Stefano, additional, Bonci, Tecla, additional, Brown, Philip, additional, Brozgol, Marina, additional, Buckley, Ellen, additional, Carsin, Anne-Elie, additional, Caruso, Marco, additional, Caulfield, Brian, additional, Cereatti, Andrea, additional, Chiari, Lorenzo, additional, Chynkiamis, Nikolaos, additional, Ciravegna, Fabio, additional, Del Din, Silvia, additional, Eskofier, Björn, additional, Evers, Jordi, additional, Garcia Aymerich, Judith, additional, Gazit, Eran, additional, Hansen, Clint, additional, Hausdorff, Jeffrey M, additional, Helbostad, Jorunn L, additional, Hiden, Hugo, additional, Hume, Emily, additional, Paraschiv-Ionescu, Anisoara, additional, Ireson, Neil, additional, Keogh, Alison, additional, Kirk, Cameron, additional, Kluge, Felix, additional, Koch, Sarah, additional, Küderle, Arne, additional, Lanfranchi, Vitaveska, additional, Maetzler, Walter, additional, Micó-Amigo, M Encarna, additional, Mueller, Arne, additional, Neatrour, Isabel, additional, Niessen, Martijn, additional, Palmerini, Luca, additional, Pluimgraaff, Lucas, additional, Reggi, Luca, additional, Salis, Francesca, additional, Schwickert, Lars, additional, Scott, Kirsty, additional, Sharrack, Basil, additional, Sillen, Henrik, additional, Singleton, David, additional, Soltani, Abolfazi, additional, Taraldsen, Kristin, additional, Ullrich, Martin, additional, Van Gelder, Linda, additional, Vereijken, Beatrix, additional, Vogiatzis, Ioannis, additional, Warmerdam, Elke, additional, Yarnall, Alison, additional, and Rochester, Lynn, additional
- Published
- 2021
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19. Risk of Several Cancers is Higher in Urban Areas after Adjusting for Socioeconomic Status. Results from a Two-Country Population-Based Study of 18 Common Cancers
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Sharp, Linda, Donnelly, David, Hegarty, Avril, Carsin, Anne-Elie, Deady, Sandra, McCluskey, Neil, Gavin, Anna, and Comber, Harry
- Published
- 2014
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20. The use of household cleaning products during pregnancy and lower respiratory tract infections and wheezing during early life
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Casas, Lidia, Zock, Jan Paul, Carsin, Anne Elie, Fernandez-Somoano, Ana, Esplugues, Ana, Santa-Marina, Loreto, Tardón, Adonina, Ballester, Ferran, Basterrechea, Mikel, and Sunyer, Jordi
- Published
- 2013
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21. A cohort study on full breastfeeding and child neuropsychological development: the role of maternal social, psychological, and nutritional factors
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Julvez, Jordi, Guxens, Monica, Carsin, Anne-Elie, Forns, Joan, Mendez, Michelle, Turner, Michelle C, and Sunyer, Jordi
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- 2014
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22. The effect of physical activity on asthma incidence over 10 years: population-based study
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Russell, Melissa Anne, primary, Dharmage, Shyamali, additional, Fuertes, Elaine, additional, Marcon, Alessandro, additional, Carsin, Anne-Elie, additional, Pascual Erquicia, Silvia, additional, Heinrich, Joachim, additional, Johannessen, Ane, additional, Abramson, Michael J., additional, Amaral, Andre F.S., additional, Cerveri, Isa, additional, Demoly, Pascal, additional, Garcia-Larsen, Vanessa, additional, Jarvis, Deborah, additional, Martinez-Moratalla, Jesus, additional, Nowak, Dennis, additional, Palacios-Gomez, Leopoldo, additional, Squillacioti, Giulia, additional, Raza, Wasif, additional, Emtner, Margareta, additional, and Garcia-Aymerich, Judith, additional
- Published
- 2021
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23. Regular physical activity levels and incidence of restrictive spirometry pattern: a longitudinal analysis of two population-based cohorts
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Carsin, Anne-Elie, Keidel, Dirk, Fuertes, Elaine, Imboden, Medea, Weyler, Joost, Nowak, Dennis, Heinrich, Joachim, Pascual Erquicia Silvia, Martinez-Moratalla, Jesus, Huerta, Ismael, Sanchez, Jose-Luis, Schaffner, Emmanuel, Caviezel, Serena, Beckmeyer-Borowko, Anna, Raherison, Chantal, Pin, Isabelle, Demoly, Pascal, Leynaert, Bénédicte, Cerveri, Isa, Squillacioti, Giulia, Accordini, Simone, Gislason, Thorarinn, Svanes, Cecilie, Toren, Kjell, Forsberg, Bertil, Janson, Christer, Jogi, Rain, Emtner, Margareta, Gómez Real Francisco, Jarvis, Debbie, Guerra, Stefano, Dharmage Shyamali, C, Probst-Hensch, Nicole, Garcia-Aymerich, Judith, and European Union's Horizon 2020 research and innovation programme
- Subjects
BMI ,FVC ,Physical activity ,restrictive spirometry ,spirometry ,Adult ,Aged, 80 and over ,Male ,Epidemiology ,Incidence ,Vital Capacity ,physical activity ,Middle Aged ,Respiration Disorders ,Europe ,Forced Expiratory Volume ,Humans ,Female ,Longitudinal Studies ,Exercise ,01 Mathematical Sciences ,11 Medical and Health Sciences ,Aged - Abstract
A restrictive spirometry pattern is associated with high morbidity and mortality. Whether practicing regular physical activity protects against this pattern has never been studied. We estimated the association between regular physical activity and the incidence of restrictive spirometry pattern. Forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC) and physical activity were assessed between 2000–2002 in the ECRHS (n=2,757, 39-67 years) and SAPALDIA (n=2,610, 36–82 years) population-based European cohorts, and again approximately 10-years later (2010–2013). Subjects with restrictive or obstructive spirometry pattern at baseline were excluded. We assessed the association of being active at baseline (defined as being physically active ≥2-3 times/wk for ≥1 h) with restrictive spirometry pattern at follow-up (defined as a post-bronchodilator FEV1/FVC ≥Lower Limit of Normal and FVC
- Published
- 2020
24. Maternal pre-pregnancy overweight and obesity, and child neuropsychological development: two Southern European birth cohort studies
- Author
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Casas, Maribel, Chatzi, Leda, Carsin, Anne-Elie, Amiano, Pilar, Guxens, Mònica, Kogevinas, Manolis, Koutra, Katerina, Lertxundi, Nerea, Murcia, Mario, Rebagliato, Marisa, Riaño, Isolina, Rodríguez-Bernal, Clara L, Roumeliotaki, Theano, Sunyer, Jordi, Mendez, Michelle, and Vrijheid, Martine
- Published
- 2013
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25. Child neurodevelopment in a Bolivian mining city
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Ruiz-Castell, María, Paco, Pamela, Barbieri, Flavia-Laura, Duprey, Jean-Louis, Forns, Joan, Carsin, Anne-Elie, Freydier, Rémi, Casiot, Corinne, Sunyer, Jordi, and Gardon, Jacques
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- 2012
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26. Physical activity and lung function—Cause or consequence?
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Bédard, Annabelle, primary, Carsin, Anne-Elie, additional, Fuertes, Elaine, additional, Accordini, Simone, additional, Dharmage, Shyamali C., additional, Garcia-Larsen, Vanessa, additional, Heinrich, Joachim, additional, Janson, Christer, additional, Johannessen, Ane, additional, Leynaert, Bénédicte, additional, Sánchez-Ramos, José Luis, additional, Peralta, Gabriela P., additional, Pin, Isabelle, additional, Squillacioti, Giulia, additional, Weyler, Joost, additional, Jarvis, Deborah, additional, and Garcia-Aymerich, Judith, additional
- Published
- 2020
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27. Regular Physical Activity Levels and Incidence of Restrictive Spirometry Pattern: A Longitudinal Analysis of 2 Population-Based Cohorts
- Author
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Carsin, Anne-Elie, primary, Keidel, Dirk, additional, Fuertes, Elaine, additional, Imboden, Medea, additional, Weyler, Joost, additional, Nowak, Dennis, additional, Heinrich, Joachim, additional, Erquicia, Silvia Pascual, additional, Martinez-Moratalla, Jesus, additional, Huerta, Ismael, additional, Sanchez, Jose-Luis, additional, Schaffner, Emmanuel, additional, Caviezel, Seraina, additional, Beckmeyer-Borowko, Anna, additional, Raherison, Chantal, additional, Pin, Isabelle, additional, Demoly, Pascal, additional, Leynaert, Bénédicte, additional, Cerveri, Isa, additional, Squillacioti, Giulia, additional, Accordini, Simone, additional, Gislason, Thorarinn, additional, Svanes, Cecilie, additional, Toren, Kjell, additional, Forsberg, Bertill, additional, Janson, Christer, additional, Jogi, Rain, additional, Emtner, Margareta, additional, Real, Francisco Gómez, additional, Jarvis, Debbie, additional, Guerra, Stefano, additional, Dharmage, Shyamali C, additional, Probst-Hensch, Nicole, additional, and Garcia-Aymerich, Judith, additional
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- 2020
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28. Individual circadian preference (chronotype) is associated with asthma and allergic symptoms among adolescents
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Haldar, Prasun, primary, Carsin, Anne-Elie, additional, Debnath, Smriti, additional, Maity, Santi Gopal, additional, Annesi-Maesano, Isabella, additional, Garcia-Aymerich, Judith, additional, Bandyopadhayay, Arghya, additional, Moitra, Saibal, additional, Kogevinas, Manolis, additional, and Moitra, Subhabrata, additional
- Published
- 2020
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29. Prenatal ambient air pollution, placental mitochondrial DNA content, and birth weight in the INMA (Spain) and ENVIRONAGE (belgium) birth cohorts
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Clemente, Diana B.P., Casas, Maribel, Vilahur, Nadia, Begiristain, Haizea, Bustamante, Mariona, Carsin, Anne-Elie, Fernandez, Mariana F., Fierens, Frans, Gyselaers, Wilfried, Iniguez, Carmen, Janssen, Bram G., Lefebvre, Wouter, Llop, Sabrina, Olea, Nicolas, Pedersen, Marie, Pieters, Nicky, Marina, Loreto Santa, Souto, Ana, Tardon, Adonina, Vanpoucke, Charlotte, Vrijheid, Martine, Sunyer, Jordi, and Nawrot, Tim S.
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Fetus -- Growth ,Birth weight, Low -- Research -- Causes of ,Air pollution -- Research -- Influence ,Mitochondrial DNA -- Research -- Analysis ,Environmental issues ,Health - Abstract
BACKGROUND: Mitochondria are sensitive to environmental toxicants due to their lack of repair capacity. Changes in mitochondrial DNA (mtDNA) content may represent a biologically relevant intermediate outcome in mechanisms linking air pollution and fetal growth restriction. OBJECTIVE: We investigated whether placental mtDNA content is a possible mediator of the association between prenatal nitrogen dioxide (N[O.sub.2]) exposure and birth weight. METHODS: We used data from two independent European cohorts: INMA (n = 376; Spain) and ENVIRONAGE (n = 550; Belgium). Relative placental mtDNA content was determined as the ratio of two mitochondrial genes (MT-ND1 and MTF3212/R3319) to two control genes (RPLP0 and ACTB). Effect estimates for individual cohorts and the pooled data set were calculated using multiple linear regression and mixed models. We also performed a mediation analysis. RESULTS: Pooled estimates indicated that a 10-µg/[m.sup.3] increment in average N[O.sub.2] exposure during pregnancy was associated with a 4.9% decrease in placental mtDNA content (95% CI: -9.3, -0.3%) and a 48-g decrease (95% CI: -87, -9 g) in birth weight. However, the association with birth weight was significant for INMA (-66 g; 95% CI: -111, -23 g) but not for ENVIRONAGE (-20 g; 95% CI: -101, 62 g). Placental mtDNA content was associated with significantly higher mean birth weight (pooled analysis, interquartile range increase: 140 g; 95% CI: 43, 237 g). Mediation analysis estimates, which were derived for the INMA cohort only, suggested that 10% (95% CI: 6.6, 13.0 g) of the association between prenatal N[O.sub.2] and birth weight was mediated by changes in placental mtDNA content. CONCLUSION: Our results suggest that mtDNA content can be one of the potential mediators of the association between prenatal air pollution exposure and birth weight. http://dx.doi.org/10.1289/ehp.1408981, Introduction In recent years, traffic-related air pollution has been considered an important risk factor for adverse reproductive health effects. Prenatal exposure to nitrogen dioxide (N[O.sub.2]) has been associated with low [...]
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- 2016
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30. Occupational exposures and incidence of chronic bronchitis and related symptoms over two decades: the European Community Respiratory Health Survey
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Lytras, Theodore, Kogevinas, Manolis, Kromhout, Hans, Carsin, Anne Elie, Antó, Josep Maria, Bentouhami, Hayat, Weyler, Joost, Heinrich, Joachim, Nowak, Dennis, Urrutia, Isabel, Martínez-Moratalla, Jesús, Gullón, José Antonio, Vega, Antonio Pereira, Raherison Semjen, Chantal, Pin, Isabelle, Demoly, Pascal, Leynaert, Bénédicte, Villani, Simona, Gíslason, Thorarinn, Svanes, Øistein, Holm, Mathias, Forsberg, Bertil, Norbäck, Dan, Mehta, Amar J., Probst-Hensch, Nicole, Benke, Geza, Jogi, Rain, Torén, Kjell, Sigsgaard, Torben, Schlünssen, Vivi, Olivieri, Mario, Blanc, Paul D., Watkins, John, Bono, Roberto, Buist, A. Sonia, Vermeulen, Roel, Jarvis, Deborah, Zock, Jan Paul, One Health Chemisch, dIRAS RA-2, Dep IRAS, Universitat Pompeu Fabra [Barcelona] (UPF), Instituto de Salud Global - Institute For Global Health [Barcelona] (ISGlobal), Center for Genomic Regulation (CRG-UPF), CIBER de Epidemiología y Salud Pública (CIBERESP), Division of Occupational and Environmental Health, Institute for Risk Assessment (IRAS), Utrecht University [Utrecht], University of Antwerp (UA), Universiteit Antwerpen [Antwerpen], Ludwig-Maximilians-Universität München (LMU), Galdakao Hospital, Complejo Hospitalario Universitario de Albacete, Respiratory Department, Hospital Universitario San Agustín (HUSA), Universidad de Huelva, Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB), Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Centre Hospitalier Universitaire [Grenoble] (CHU), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Sorbonne Université - Département de santé publique, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Tenon [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Physiopathologie et Epidémiologie des Maladies Respiratoires (PHERE (UMR_S_1152 / U1152)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), University of Pavia, Landspitali National University Hospital of Iceland, Haukeland University Hospital, University of Bergen (UiB), University of Gothenburg (GU), Umeå University, Uppsala University Hospital, Boston Public Health Commission (Office of Research and Evaluation), Swiss Tropical and Public Health Institute [Basel], Monash University [Clayton], University of Tartu, Sahlgrenska Academy at University of Gothenburg [Göteborg], Aarhus University Hospital, Department of Public Health [Copenhagen, Denmark] (Danish Ramazzini Centre), Aarhus University [Aarhus]-The National Research Center for Work Environment [Copenhagen, Denmark], University of Verona (UNIVR), University of California [San Francisco] (UCSF), University of California, Cardiff University, University of Turin, Oregon Health and Science University [Portland] (OHSU), University Medical Center [Utrecht], Imperial College London, Salvy-Córdoba, Nathalie, Universiteit Antwerpen = University of Antwerpen [Antwerpen], Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Università degli Studi di Pavia = University of Pavia (UNIPV), Università degli studi di Verona = University of Verona (UNIVR), University of California [San Francisco] (UC San Francisco), University of California (UC), Università degli studi di Torino = University of Turin (UNITO), One Health Chemisch, dIRAS RA-2, Dep IRAS, Medical Research Council (MRC), and Commission of the European Communities
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Male ,Chronic bronchitis ,Epidemiology ,[SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract ,0302 clinical medicine ,1599 Other Commerce, Management, Tourism and Services ,Risk Factors ,Medicine ,longitudinal studies ,030212 general & internal medicine ,Respiratory system ,COPD ,Incidence (epidemiology) ,Incidence ,Longitudinal studies ,epidemiology ,respiratory ,retrospective exposure assessment ,Smoking ,Dust ,Middle Aged ,030210 environmental & occupational health ,3. Good health ,Bronchitis, Chronic ,Europe ,Respiratory ,Female ,Public Health ,Gases ,Adult ,medicine.medical_specialty ,European community ,Pulmonary disease ,Environmental & Occupational Health ,1117 Public Health and Health Services ,03 medical and health sciences ,Internal medicine ,Occupational Exposure ,Humans ,Pesticides ,MESH: Bronchitis, Chronic / etiology ,Gases / adverse effects ,Health Surveys ,Europe / epidemiology ,United States / epidemiology ,Smoking / adverse effects ,Respiratory health ,Retrospective exposure assessment ,business.industry ,Environmental and Occupational Health ,Public Health, Environmental and Occupational Health ,Australia ,1103 Clinical Sciences ,medicine.disease ,United States ,Cough ,[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie ,[SDV.MHEP.PSR] Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,Human medicine ,business - Abstract
ObjectivesChronic bronchitis (CB) is an important chronic obstructive pulmonary disease (COPD)-related phenotype, with distinct clinical features and prognostic implications. Occupational exposures have been previously associated with increased risk of CB but few studies have examined this association prospectively using objective exposure assessment. We examined the effect of occupational exposures on CB incidence in the European Community Respiratory Health Survey.MethodsPopulation samples aged 20–44 were randomly selected in 1991–1993, and followed up twice over 20 years. Participants without chronic cough or phlegm at baseline were analysed. Coded job histories during follow-up were linked to the ALOHA Job Exposure Matrix, generating occupational exposure estimates to 12 categories of chemical agents. Their association with CB incidence over both follow-ups was examined with Poisson models using generalised estimating equations.Results8794 participants fulfilled the inclusion criteria, contributing 13 185 observations. Only participants exposed to metals had a higher incidence of CB (relative risk (RR) 1.70, 95% CI 1.16 to 2.50) compared with non-exposed to metals. Mineral dust exposure increased the incidence of chronic phlegm (RR 1.72, 95% CI 1.43 to 2.06). Incidence of chronic phlegm was increased in men exposed to gases/fumes and to solvents and in women exposed to pesticides.ConclusionsOccupational exposures are associated with chronic phlegm and CB, and the evidence is strongest for metals and mineral dust exposure. The observed differences between men and women warrant further investigation.
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- 2019
31. Transient receptor potential genes, smoking, occupational exposures and cough in adults
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Smit Lidwien AM, Kogevinas Manolis, Antó Josep M, Bouzigon Emmanuelle, González Juan, Le Moual Nicole, Kromhout Hans, Carsin Anne-Elie, Pin Isabelle, Jarvis Deborah, Vermeulen Roel, Janson Christer, Heinrich Joachim, Gut Ivo, Lathrop Mark, Valverde Miguel A, Demenais Florence, and Kauffmann Francine
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Asthma ,Gene-environment interaction ,Irritant exposure ,Smoking ,TRP channel ,Diseases of the respiratory system ,RC705-779 - Abstract
Abstract Background Transient receptor potential (TRP) vanilloid and ankyrin cation channels are activated by various noxious chemicals and may play an important role in the pathogenesis of cough. The aim was to study the influence of single nucleotide polymorphisms (SNPs) in TRP genes and irritant exposures on cough. Methods Nocturnal, usual, and chronic cough, smoking, and job history were obtained by questionnaire in 844 asthmatic and 2046 non-asthmatic adults from the Epidemiological study on the Genetics and Environment of Asthma (EGEA) and the European Community Respiratory Health Survey (ECRHS). Occupational exposures to vapors, gases, dusts, and/or fumes were assessed by a job-exposure matrix. Fifty-eight tagging SNPs in TRPV1, TRPV4, and TRPA1 were tested under an additive model. Results Statistically significant associations of 6 TRPV1 SNPs with cough symptoms were found in non-asthmatics after correction for multiple comparisons. Results were consistent across the eight countries examined. Haplotype-based association analysis confirmed the single SNP analyses for nocturnal cough (7-SNP haplotype: p-global = 4.8 × 10-6) and usual cough (9-SNP haplotype: p-global = 4.5 × 10-6). Cough symptoms were associated with exposure to irritants such as cigarette smoke and occupational exposures (p < 0.05). Four polymorphisms in TRPV1 further increased the risk of cough symptoms from irritant exposures in asthmatics and non-asthmatics (interaction p < 0.05). Conclusions TRPV1 SNPs were associated with cough among subjects without asthma from two independent studies in eight European countries. TRPV1 SNPs may enhance susceptibility to cough in current smokers and in subjects with a history of workplace exposures.
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- 2012
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32. The dyspnoea-inactivity vicious circle in COPD: development and external validation of a conceptual model
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Ramon, Maria A., Riet, Gerben Ter, Carsin, Anne-Elie, Gimeno-Santos, Elena, Agustí, Alvar, Antó, Josep M., Donaire-Gonzalez, David, Ferrer, Jaume, Rodríguez, Esther, Rodriguez-Roisin, Robert, Puhan, Milo A., Garcia-Aymerich, Judith, PAC-COPD Study Group, University of Zurich, and Garcia-Aymerich, Judith
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Pulmonary and Respiratory Medicine ,Male ,medicine.medical_specialty ,Internationality ,Exacerbation ,media_common.quotation_subject ,610 Medicine & health ,Hyperinflation ,Severity of Illness Index ,Structural equation modeling ,03 medical and health sciences ,Pulmonary Disease, Chronic Obstructive ,0302 clinical medicine ,Physical medicine and rehabilitation ,Forced Expiratory Volume ,medicine ,Humans ,030212 general & internal medicine ,Exercise ,Lung ,media_common ,Aged ,COPD ,business.industry ,10060 Epidemiology, Biostatistics and Prevention Institute (EBPI) ,Middle Aged ,Models, Theoretical ,medicine.disease ,Obstructive lung disease ,Virtuous circle and vicious circle ,respiratory tract diseases ,Dyspnea ,030228 respiratory system ,2740 Pulmonary and Respiratory Medicine ,Cohort ,Conceptual model ,Disease Progression ,Female ,business - Abstract
The vicious circle of dyspnoea–inactivity has been proposed, but never validated empirically, to explain the clinical course of chronic obstructive pulmonary disease (COPD). We aimed to develop and validate externally a comprehensive vicious circle model.We utilised two methods. 1) Identification and validation of all published vicious circle models by a systematic literature search and fitting structural equation models to longitudinal data from the Spanish PAC-COPD (Phenotype and Course of COPD) cohort (n=210, mean age 68 years, mean forced expiratory volume in 1 s (FEV1) 54% predicted), testing both the hypothesised relationships between variables in the model (“paths”) and model fit. 2) Development of a new model and external validation using longitudinal data from the Swiss and Dutch ICE COLD ERIC (International Collaborative Effort on Chronic Obstructive Lung Disease: Exacerbation Risk Index Cohorts) cohort (n=226, mean age 66 years, mean FEV157% predicted).We identified nine vicious circle models for which structural equation models confirmed most hypothesised paths but showed inappropriate fit. In the new model, airflow limitation, hyperinflation, dyspnoea, physical activity, exercise capacity and COPD exacerbations remained related to other variables and model fit was appropriate. Fitting it to ICE COLD ERIC, all paths were replicated and model fit was appropriate.Previously published vicious circle models do not fully explain the vicious circle concept. We developed and externally validated a new comprehensive model that gives a more relevant role to exercise capacity and COPD exacerbations.
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- 2018
33. Genetic regulation ofmethylation and IL1RL1-a protein levels in asthma
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Dijk, F Nicole, Xu, Chengjian, Melén, Erik, Carsin, Anne-Elie, Kumar, Asish, Nolte, Ilja M, Gruzieva, Olena, Pershagen, Goran, Grotenboer, Neomi S, Savenije, Olga E M, Antó, Josep Maria, Lavi, Iris, Dobaño, Carlota, Bousquet, Jean, van der Vlies, Pieter, van der Valk, Ralf J P, de Jongste, Johan C, Nawijn, Martijn C, Guerra, Stefano, Postma, Dirkje S, Koppelman, Gerard H, Life Course Epidemiology (LCE), and Groningen Research Institute for Asthma and COPD (GRIAC)
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VARIANT FORM ,CYTOKINE ,AIRWAY INFLAMMATION ,PROMOTER ,HUMAN ST2 GENE ,Journal Article ,IL-33 ,GENOME-WIDE ASSOCIATION ,RECEPTOR-LIKE 1 ,POLYMORPHISMS ,METAANALYSIS ,respiratory tract diseases - Abstract
Interleukin-1 receptor-like 1 (IL1RL1) is an important asthma gene. (Epi)genetic regulation ofIL1RL1protein expression has not been established. We assessed the association betweenIL1RL1single nucleotide polymorphisms (SNPs),IL1RL1methylation and serum IL1RL1-a protein levels, and aimed to identify causal pathways in asthma.Associations ofIL1RL1SNPs with asthma were determined in the Dutch Asthma Genome-wide Association Study cohort and three European birth cohorts, BAMSE (Children/Barn, Allergy, Milieu, Stockholm, an Epidemiological survey), INMA (Infancia y Medio Ambiente) and PIAMA (Prevention and Incidence of Asthma and Mite Allergy), participating in the Mechanisms of the Development of Allergy study. We performed blood DNAIL1RL1methylation quantitative trait locus (QTL) analysis (n=496) and (epi)genome-wide protein QTL analysis on serum IL1RL1-a levels (n=1462). We investigated the association ofIL1RL1CpG methylation with asthma (n=632) and IL1RL1-a levels (n=548), with subsequent causal inference testing. Finally, we determined the association of IL1RL1-a levels with asthma and its clinical characteristics (n=1101).IL1RL1asthma-risk SNPs strongly associated withIL1RL1methylation (rs1420101; p=3.7×10-16) and serum IL1RL1-a levels (p=2.8×10-56).IL1RL1methylation was not associated with asthma or IL1RL1-a levels. IL1RL1-a levels negatively correlated with blood eosinophil counts, whereas there was no association between IL1RL1-a levels and asthma.In conclusion, asthma-associatedIL1RL1SNPs strongly regulateIL1RL1methylation and serum IL1RL1-a levels, yet neither theseIL1RL1-methylation CpG sites nor IL1RL1-a levels are associated with asthma.
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- 2018
34. The role of C-reactive protein levels on the association of physical activity with lung function in adults
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Fuertes, Elaine, primary, Carsin, Anne-Elie, additional, Garcia-Larsen, Vanessa, additional, Guerra, Stefano, additional, Pin, Isabelle, additional, Leynaert, Bénédicte, additional, Accordini, Simone, additional, Martinez-Moratalla, Jesús, additional, Antó, Josep M., additional, Urrutia, Isabel, additional, Le Gouellec, Audrey, additional, Heinrich, Joachim, additional, Gislason, Thorarinn, additional, Jõgi, Rain, additional, Janson, Christer, additional, Jarvis, Debbie, additional, and Garcia-Aymerich, Judith, additional
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- 2019
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35. The Role of Socioeconomic Status in the Association of Lung Function and Air Pollution—A Pooled Analysis of Three Adult ESCAPE Cohorts
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Keidel, Dirk, primary, Anto, Josep Maria, additional, Basagaña, Xavier, additional, Bono, Roberto, additional, Burte, Emilie, additional, Carsin, Anne-Elie, additional, Forsberg, Bertil, additional, Fuertes, Elaine, additional, Galobardes, Bruna, additional, Heinrich, Joachim, additional, de Hoogh, Kees, additional, Jarvis, Debbie, additional, Künzli, Nino, additional, Leynaert, Bénédicte, additional, Marcon, Alessandro, additional, Le Moual, Nicole, additional, de Nazelle, Audrey, additional, Schindler, Christian, additional, Siroux, Valérie, additional, Stempfelet, Morgane, additional, Sunyer, Jordi, additional, Temam, Sofia, additional, Tsai, Ming-Yi, additional, Varraso, Raphaëlle, additional, Jacquemin, Bénédicte, additional, and Probst-Hensch, Nicole, additional
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- 2019
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36. DNA Methylation in Inflammatory Pathways Modifies the Association between BMI and Adult-Onset Non-Atopic Asthma
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Jeong, Ayoung, primary, Imboden, Medea, additional, Ghantous, Akram, additional, Novoloaca, Alexei, additional, Carsin, Anne-Elie, additional, Kogevinas, Manolis, additional, Schindler, Christian, additional, Lovison, Gianfranco, additional, Herceg, Zdenko, additional, Cuenin, Cyrille, additional, Vermeulen, Roel, additional, Jarvis, Deborah, additional, Amaral, André, additional, Kronenberg, Florian, additional, Vineis, Paolo, additional, and Probst-Hensch, Nicole, additional
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- 2019
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37. Association between air pollution and rhinitis incidence in two European cohorts
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Burte, Emilie, Leynaert, Bénédicte, Bono, Roberto, Brunekreef, Bert, Bousquet, Jean, Carsin, Anne-Elie, De Hoogh, Kees, Forsberg, Bertil, Gormand, Frédéric, Heinrich, Joachim, Just, Jocelyne, Marcon, Alessandro, Künzli, Nino, Nieuwenhuijsen, Mark, Pin, Isabelle, Stempfelet, Morgane, Sunyer, Jordi, Villani, Simona, Siroux, Valérie, Jarvis, Deborah, Nadif, Rachel, Jacquemin, Bénédicte, One Health Chemisch, dIRAS RA-2, Vieillissement et Maladies chroniques : approches épidémiologique et de santé publique (VIMA), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM), Epidemiology & Pulmonology [Barcelona, Spain] (ISGlobal), Universitat Pompeu Fabra [Barcelona] (UPF)-Centre de Recerca en Epidemiologia Ambiental - CREAL [Barcelona, Spain]-Instituto de Salud Global - Institute For Global Health [Barcelona] (ISGlobal), Physiopathologie et Epidémiologie des Maladies Respiratoires (PHERE (UMR_S_1152 / U1152)), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Public Health and Pediatrics [Turin, Italy], University of Turin, Institute for Risk Assessment Sciences [Utrecht, The Netherlands] (IRAS), Utrecht University [Utrecht], Julius Center for Health Sciences and Primary Care [Utrecht, The Netherlands], University Medical Center [Utrecht], Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon (MACVIA-LR), Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), CHU Montpellier, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), CIBER de Epidemiología y Salud Pública (CIBERESP), Hospital del Mar Medical Research Institute [Barcelona, Spain] (IMIM), Universitat Pompeu Fabra [Barcelona] (UPF), Swiss Tropical and Public Health Institute [Basel], University of Basel (Unibas), Department of Public Health and Clinical Medicine [Umeå, Sweden] (Environmental and Occupational Medicine), Umeå University, Service de pneumologie [Centre Hospitalier Lyon Sud - HCL], Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Social and Environmental Medicine [Munich, Germany] (Institute and Outpatient Clinic for Occupational), Ludwig-Maximilians University [Munich] (LMU)-University Hospital Munich [Munich, Germany], Centre de l'Asthme et des Allergies [CHU Trousseau], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Université Pierre et Marie Curie - Paris 6 - UFR de Médecine Pierre et Marie Curie (UPMC), Université Pierre et Marie Curie - Paris 6 (UPMC), Department of Diagnostics and Public Health [Verona] (UNIVR | DDSP), University of Verona (UNIVR), Unit of Epidemiology and Medical Statistics [Verona, Italy] (Dept of Diagnostics and Public Health), Service de pédiatrie générale et maladies infectieuses [CHU Grenoble], CHU Grenoble, Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB), Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Institut de Veille Sanitaire (INVS), Unit of Biostatistics and Clinical Epidemiology [Pavia, Italy] (Dept of Public Health), University of Pavia-Experimental and Forensic Medicine [Pavia, Italy], School of Public Health [London, UK] (Faculty of Medicine), Imperial College London, Medical Research Council (MRC), One Health Chemisch, dIRAS RA-2, Università degli studi di Torino = University of Turin (UNITO), Ludwig-Maximilians-Universität München (LMU)-University Hospital Munich [Munich, Germany], Università degli studi di Verona = University of Verona (UNIVR), Università degli Studi di Pavia = University of Pavia (UNIPV)-Experimental and Forensic Medicine [Pavia, Italy], and Faraldo, Beatrice
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medicine.medical_specialty ,Air pollution ,MEDLINE ,010501 environmental sciences ,medicine.disease_cause ,01 natural sciences ,03 medical and health sciences ,0302 clinical medicine ,Environmental health ,air pollution, rhinitis, epidemiology ,Air Pollution ,Epidemiology ,MD Multidisciplinary ,medicine ,Humans ,lcsh:Environmental sciences ,0105 earth and related environmental sciences ,General Environmental Science ,Retrospective Studies ,Rhinitis ,lcsh:GE1-350 ,Air Pollutants ,business.industry ,Incidence (epidemiology) ,Incidence ,Retrospective cohort study ,030228 respiratory system ,[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie ,13. Climate action ,epidemiology ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,business ,Environmental Sciences - Abstract
International audience; BACKGROUND:The association between air pollution and rhinitis is not well established.AIM:The aim of this longitudinal analysis was to study the association between modeled air pollution at the subjects' home addresses and self-reported incidence of rhinitis.METHODS:We used data from 1533 adults from two multicentre cohorts' studies (EGEA and ECRHS). Rhinitis incidence was defined as reporting rhinitis at the second follow-up (2011 to 2013) but not at the first follow-up (2000 to 2007). Annual exposure to NO2, PM10 and PM2.5 at the participants' home addresses was estimated using land-use regression models developed by the ESCAPE project for the 2009-2010 period. Incidence rate ratios (IRR) were computed using Poisson regression. Pooled analysis, analyses by city and meta-regression testing for heterogeneity were carried out.RESULTS:No association between long-term air pollution exposure and incidence of rhinitis was found (adjusted IRR (aIRR) for an increase of 10 μg·m-3 of NO2: 1.00 [0.91-1.09], for an increase of 5 μg·m-3 of PM2.5: 0.88 [0.73-1.04]). Similar results were found in the two-pollutant model (aIRR for an increase of 10 μg·m-3 of NO2: 1.01 [0.87-1.17], for an increase of 5 μg·m-3 of PM2.5: 0.87 [0.68-1.08]). Results differed depending on the city, but no regional pattern emerged for any of the pollutants.CONCLUSIONS:This study did not find any consistent evidence of an association between long-term air pollution and incident rhinitis.
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- 2017
38. Factors prompting PSA-testing of asymptomatic men in a country with no guidelines: a national survey of general practitioners
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Sharp Linda, Carsin Anne-Elie, Drummond Frances J, and Comber Harry
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Medicine (General) ,R5-920 - Abstract
Abstract Background Increased use of prostate specific antigen (PSA) has been associated with increased prostate cancer incidence. Ireland is estimated to have one of the highest prostate cancer incidences in Europe and has no national guidelines for prostate cancer screening. GPs have a pivotal role in influencing PSA testing, therefore, our aim was to describe GP testing practices and to identify factors influencing these. Methods A postal survey, including questions on clinical practice and experience, knowledge and demographics was distributed to all GPs (n = 3,683). The main outcomes were (i) PSA testing asymptomatic men and (ii) "inappropriate" PSA testing, defined as testing asymptomatic men aged < 50 or > 75 years. Factors associated with these outcomes were identified using logistic regression. Results 1,625 GPs responded (response rate corrected for eligibility = 53%). Most respondents (79%) would PSA test asymptomatic men. Of these, 34% and 51% would test asymptomatic men < 50 and > 75 years, respectively. In multivariate analyses, GPs were more likely to test asymptomatic men if they were ≥ 50 years, in practice ≥ 10 years, female or less knowledgeable about PSA efficacy. Male GPs who would have a PSA test themselves were > 8-times more likely to PSA test asymptomatic men than GPs who would not have a test. GPs who had an asymptomatic patient diagnosed with prostate cancer following PSA testing, were > 3-times more likely to test asymptomatic men. Practice-related factors positively associated with testing included: running 'well man' clinics, performing occupational health checks and performing other tests routinely with PSA. Factors positively associated with 'inappropriate' testing included; being male and willing to have a PSA test, having worked/trained in the UK and supporting annual PSA testing. 91% of respondents supported the development of national PSA testing guidelines. Conclusion Our findings suggest that widespread PSA testing of asymptomatic men in primary care is primarily due to a combination of clinical experience, poor knowledge and the support of doctors for PSA testing, as evidenced by the willingness of male doctors to have a PSA test. There is an urgent need for education and support for GPs concerning prostate cancer screening, starting with the implementation of national guidelines.
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- 2009
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39. Association between air pollution and rhinitis incidence in two European cohorts
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Burte, Emilie, primary, Leynaert, Bénédicte, additional, Bono, Roberto, additional, Brunekreef, Bert, additional, Bousquet, Jean, additional, Carsin, Anne-Elie, additional, De Hoogh, Kees, additional, Forsberg, Bertil, additional, Gormand, Frédéric, additional, Heinrich, Joachim, additional, Just, Jocelyne, additional, Marcon, Alessandro, additional, Künzli, Nino, additional, Nieuwenhuijsen, Mark, additional, Pin, Isabelle, additional, Stempfelet, Morgane, additional, Sunyer, Jordi, additional, Villani, Simona, additional, Siroux, Valérie, additional, Jarvis, Deborah, additional, Nadif, Rachel, additional, and Jacquemin, Bénédicte, additional
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- 2018
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40. Genetic regulation of IL1RL1 methylation and IL1RL1-a protein levels in asthma
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Dijk, F. Nicole, primary, Xu, Chengjian, additional, Melén, Erik, additional, Carsin, Anne-Elie, additional, Kumar, Asish, additional, Nolte, Ilja M., additional, Gruzieva, Olena, additional, Pershagen, Goran, additional, Grotenboer, Neomi S., additional, Savenije, Olga E.M., additional, Antó, Josep Maria, additional, Lavi, Iris, additional, Dobaño, Carlota, additional, Bousquet, Jean, additional, van der Vlies, Pieter, additional, van der Valk, Ralf J.P., additional, de Jongste, Johan C., additional, Nawijn, Martijn C., additional, Guerra, Stefano, additional, Postma, Dirkje S., additional, and Koppelman, Gerard H., additional
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- 2018
- Full Text
- View/download PDF
41. Risk of exacerbations in COPD and asthma patients living in the neighbourhood of livestock farms: Observational study using longitudinal data
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van Dijk, Christel E, Garcia-Aymerich, Judith, Carsin, Anne-Elie, Smit, Lidwien A M, Borlée, Floor, Heederik, Dick J, Donker, Gé A, Yzermans, C Joris, Zock, Jan-Paul, LS IRAS EEPI GRA (Gezh.risico-analyse), dIRAS RA-I&I RA, LS IRAS EEPI GRA (Gezh.risico-analyse), and dIRAS RA-I&I RA
- Subjects
Adult ,Male ,Risk ,medicine.medical_specialty ,Farms ,Livestock ,Exacerbation ,Adolescent ,Coronacrisis-Taverne ,Exacerbations ,03 medical and health sciences ,Pulmonary Disease, Chronic Obstructive ,Young Adult ,0302 clinical medicine ,Environmental health ,medicine ,Animals ,Humans ,COPD ,Respiratory function ,030212 general & internal medicine ,Risk factor ,Intensive care medicine ,Asthma ,Aged ,Netherlands ,Aged, 80 and over ,business.industry ,Public Health, Environmental and Occupational Health ,Environmental exposure ,Middle Aged ,medicine.disease ,respiratory tract diseases ,030228 respiratory system ,Observational study ,Female ,Rural area ,business - Abstract
Objective Living in an area with a high density of livestock farms has been associated with adverse respiratory health effects in some studies. As patients with COPD and asthma already have a compromised respiratory function and chronic airway inflammation, they are expected to be at increased risk for adverse respiratory health effects. The objective of this study was to assess the association between livestock exposure and exacerbations in COPD and asthma. Methods 899 COPD and 2546 asthma patients from 15 general practices in a rural area with a high livestock density and 933 COPD and 2310 asthma patients from 15 practices in a control area in the Netherlands were included. Occurrence of exacerbations was based on the pharmaceutical treatment of exacerbations in COPD and asthma patients using 2006–2012 prescription data of electronic medical records. Farm exposure was assessed by comparing the study area with the control area, and with individual exposure estimates in the study area using Geographic Information System data. Results The exacerbation rate was higher in the study area compared with the control area in COPD (IRR: 1.28; 95%CI: 1.06–1.55), but not in asthma patients (IRR: 0.87; 95%CI: 0.72–1.05). In general, individual exposure estimates in the study area were not associated with exacerbations. COPD patients living within a 500 m radius of up to12,499 chickens had a 36% higher exacerbation rate (IRR: 1.36; 95%CI: 1.03–1.79). Conclusions Living in an area with a high livestock density is a risk factor for exacerbations in COPD patients. The environmental exposure responsible for this increased risk remains to be elucidated.
- Published
- 2016
42. Respiratory symptoms are more common among short sleepers independent of obesity
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Björnsdóttir, Erla, primary, Janson, Christer, additional, Lindberg, Eva, additional, Arnardottir, Erna Sif, additional, Benediktsdóttir, Bryndís, additional, Garcia-Aymerich, Judith, additional, Carsin, Anne Elie, additional, Real, Francisco Gómez, additional, Torén, Kjell, additional, Heinrich, Joachim, additional, Nowak, Dennis, additional, Sánchez-Ramos, José Luis, additional, Demoly, Pascal, additional, Arenas, Sandra Dorado, additional, Navarro, Ramon Coloma, additional, Schlünssen, Vivi, additional, Raherison, Chantal, additional, Jarvis, Debbie L, additional, and Gislason, Thorarinn, additional
- Published
- 2017
- Full Text
- View/download PDF
43. Health-related quality of life and risk factors associated with spirometric restriction
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Guerra, Stefano, primary, Carsin, Anne-Elie, additional, Keidel, Dirk, additional, Sunyer, Jordi, additional, Leynaert, Bénédicte, additional, Janson, Christer, additional, Jarvis, Debbie, additional, Stolz, Daiana, additional, Rothe, Thomas, additional, Pons, Marco, additional, Turk, Alexander, additional, Anto, Josep M., additional, and Probst-Hensch, Nicole, additional
- Published
- 2017
- Full Text
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44. Socioeconomic position and outdoor nitrogen dioxide (NO2) exposure in Western Europe: A multi-city analysis
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Temam, Sofia, primary, Burte, Emilie, additional, Adam, Martin, additional, Antó, Josep M., additional, Basagaña, Xavier, additional, Bousquet, Jean, additional, Carsin, Anne-Elie, additional, Galobardes, Bruna, additional, Keidel, Dirk, additional, Künzli, Nino, additional, Le Moual, Nicole, additional, Sanchez, Margaux, additional, Sunyer, Jordi, additional, Bono, Roberto, additional, Brunekreef, Bert, additional, Heinrich, Joachim, additional, de Hoogh, Kees, additional, Jarvis, Debbie, additional, Marcon, Alessandro, additional, Modig, Lars, additional, Nadif, Rachel, additional, Nieuwenhuijsen, Mark, additional, Pin, Isabelle, additional, Siroux, Valérie, additional, Stempfelet, Morgane, additional, Tsai, Ming-Yi, additional, Probst-Hensch, Nicole, additional, and Jacquemin, Bénédicte, additional
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- 2017
- Full Text
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45. Adult lung function and long-term air pollution exposure. ESCAPE: a multicentre cohort study and meta-analysis
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Adam, Martin, Carsin, Anne-Elie, Jacquemin Leonard, Bénédicte, Cirach, Marta, Nieuwenhuijsen, Mark J., Sunyer Deu, Jordi, and Probst-Hensch, Nicole
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Pulmons -- Fisiologia patològica ,Aire -- Contaminació - Abstract
The chronic impact of ambient air pollutants on lung function in adults is not fully understood. The objective of this study was to investigate the association of long-term exposure to ambient air pollution with lung function in adult participants from five cohorts in the European Study of Cohorts for Air Pollution Effects (ESCAPE). Residential exposure to nitrogen oxides (NO₂, NOx) and particulate matter (PM) was modelled and traffic indicators were assessed in a standardised manner. The spirometric parameters forced expiratory volume in 1 s (FEV₁) and forced vital capacity (FVC) from 7613 subjects were considered as outcomes. Cohort-specific results were combined using meta-analysis. We did not observe an association of air pollution with longitudinal change in lung function, but we observed that a 10 μg·m(-3) increase in NO₂ exposure was associated with lower levels of FEV₁ (-14.0 mL, 95% CI -25.8 to -2.1) and FVC (-14.9 mL, 95% CI -28.7 to -1.1). An increase of 10 μg·m(-3) in PM10, but not other PM metrics (PM2.5, coarse fraction of PM, PM absorbance), was associated with a lower level of FEV₁ (-44.6 mL, 95% CI -85.4 to -3.8) and FVC (-59.0 mL, 95% CI -112.3 to -5.6). The associations were particularly strong in obese persons. This study adds to the evidence for an adverse association of ambient air pollution with lung function in adults at very low levels in Europe. ECRHS was supported by the European Commission, as part of their Quality of Life program. The coordination of ECRHS II was supported by the European Commission, as part of their Quality of Life programme. The following bodies funded the local studies in ECRHS II in this article: Albacete-Fondo de Investigaciones Santarias (grant code: 97/0035-01, 13 99/0034-01, and 99/0034-02) (Hospital Universitario de Albacete, Consejeria de Sanidad); Antwerp-FWO Fund for Scientific Research), Flanders, Belgium (grant code: G.0402.00) (University of Antwerp, Flemish Health Ministry); Barcelona-Fondo de Investigaciones Sanitarias (grant code: 99/0034-01, and 99/0034-02), Red Respira (RTIC 03/11 ISC IIF); Ciber of Epidemiology and Public Health was established and founded by Instituto de Salud Carlos III; Erfurt-GSF–National Research Centre for Environment and Health, Deutsche Forschungsgemeinschaft (DFG) (grant code FR 1526/1-1); Galdakao-Basque Health Department; Grenoble-Programme Hospitalier de Recherche Clinique-DRC de Grenoble 2000 no.2610, Ministry of Health, Direction de la Recherche Clinique, Ministere de l’Emploi et de la Solidarite, Direction Generale de la Sante, CHU de Grenoble, Comite des Maladies Respiratoires de l’Isere; Ipswich and Norwich-National Asthma Campaign (UK); Huelva-Fondo de Investigaciones Sanitarias (FIS) (grant code:/n97/0035-01, 99/0034-01, and 99/0034-02); Oviedo-Fondo de Investigaciones Santarias (FIS) (grant code: 97/0035-01, 99//n0034-01, and 99/0034-02); Paris-Ministere de l’Emploi et de la Solidarite, Direction Generale de la Sante, UCBPharma/n(France), Aventis (France), Glaxo France, Programme Hospitalier de Recherche Clinique-DRC de Grenoble 2000 no. 2610, Ministry of Health, Direction de la Recherche Clinique, CHU de Grenoble; measurements and models for PM in Grenoble (ECRHS) were funded by Region Rhônes-Alpes; Pavia-Glaxo, Smith and Kline Italy, Italian Ministry of University and Scientific and Technological Research (MURST), Local University Funding for Research 1998 and 1999 (Pavia, Italy); Turin-ASL 4 Regione Piemonte (Italy), AO CTO/ICORMA Regione Piemonte (Italy), Ministero dell’Università e della Ricerca Scientifica (Italy), Glaxo Wellcome spa (Verona, Italy); Umeå-Swedish Heart Lung Foundation, Swedish Foundation for Health Care Sciences and Allergy Research, Swedish Asthma and Allergy Foundation, Swedish Cancer and Allergy Foundation; Verona-University of Verona; Italian Ministry of University and Scientific and Technological Research (MURST); Glaxo, Smith and Kline Italy. EGEA is funded in part by PHRC-Paris, PHRC-Grenoble, ANR 05-SEST-020-02/05-9-97, ANR-06-CEBS, ANRCES-2009, Région Nord Pas-de-Calais, Merck Sharp and Dohme (MSD). NSHD and Profs R. Hardy and D. Kuh are supported by core funding and grant funding (U1200632239 and/nU12309272) from the UK Medical Research Council. The authors acknowledge the NSHD participants and the NSHD/nscientific and data collection teams. SALIA received funds from the German state (NRW) and federal Ministries of the Environment. The follow-up investigation was funded by the DGUV (German statutory accident assurance) VT 266.1. SAPALDIA received funds from the Swiss National Science Foundation (grants no 33CSCO-134276/1, 33CSCO-108796, 3247BO-104283, 3247BO-104288, 3247BO-104284, 3247-065896, 3100-059302, 3200-052720, 3200-042532, 4026-028099), the Federal Office for Forest, Environment and Landscape and several Federal and Cantonal authorities.
- Published
- 2015
46. Human leukocyte antigen class II variants and adult-onset asthma: does occupational allergen exposure play a role?
- Author
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Smit, Lidwien A M, Strachan, David P, Vermeulen, Roel, de Bakker, Paul I W, Demenais, Florence, Dumas, Orianne, Carsin, Anne-Elie, Cullinan, Paul, Curjuric, Ivan, Ghosh, Rebecca E, Heederik, Dick, Imboden, Medea, Jarvis, Deborah, Lathrop, Mark, Le Moual, Nicole, Mehta, Amar, Miedinger, David, Sigsgaard, Torben, Siroux, Valérie, Vernez, David, Zock, Jan Paul, Kauffmann, Francine, Probst-Hensch, Nicole, Kogevinas, Manolis, Bouzigon, Emmanuelle, LS IRAS EEPI GRA (Gezh.risico-analyse), Dep IRAS, Risk Assessment of Toxic and Immunomodulatory Agents, IRAS RATIA-SIB, LS IRAS EEPI GRA (Gezh.risico-analyse), Dep IRAS, Risk Assessment of Toxic and Immunomodulatory Agents, and IRAS RATIA-SIB
- Subjects
Pulmonary and Respiratory Medicine ,Adult ,Male ,Adolescent ,Genotype ,Coronacrisis-Taverne ,Genome-wide association study ,Human leukocyte antigen ,medicine.disease_cause ,Polymorphism, Single Nucleotide ,Cohort Studies ,Young Adult ,Allergen ,immune system diseases ,HLA-DQ Antigens ,Occupational Exposure ,medicine ,Odds Ratio ,HLA-DQ beta-Chains ,Humans ,Allele ,Alleles ,Genetic association ,Asthma ,HLA-DQ Antigen ,business.industry ,Histocompatibility Antigens Class II ,Allergens ,Middle Aged ,medicine.disease ,respiratory tract diseases ,Europe ,Molecular Weight ,Immunology ,Female ,business ,Genome-Wide Association Study ,HLA-DRB1 Chains - Abstract
Recently, a locus centred on rs9273349 in the HLA-DQ region emerged from genome-wide association studies of adult-onset asthma. We aimed to further investigate the role of human leukocyte antigen (HLA) class II in adult-onset asthma and a possible interaction with occupational exposures.We imputed classical HLA-II alleles from 7579 single-nucleotide polymorphisms in 6025 subjects (1202 with adult-onset asthma) from European cohorts: ECRHS, SAPALDIA, EGEA and B58C, and from surveys of bakers and agricultural workers. Based on an asthma-specific job–exposure matrix, 2629 subjects had ever been exposed to high molecular weight (HMW) allergens. We explored associations between 23 common HLA-II alleles and adult-onset asthma, and tested for gene–environment interaction with occupational exposure to HMW allergens. Interaction was also tested for rs9273349.Marginal associations of classical HLA-II alleles and adult-onset asthma were not statistically significant. Interaction was detected between the DPB1*03:01 allele and exposure to HMW allergens (p = 0.009), in particular to latex (p = 0.01). In the unexposed group, the DPB1*03:01 allele was associated with adult-onset asthma (OR 0.67, 95%CI 0.53–0.86). HMW allergen exposures did not modify the association of rs9273349 with adult-onset asthma.Common classical HLA-II alleles were not marginally associated with adult-onset asthma. The association of latex exposure and adult-onset asthma may be modified by DPB1*03:01.
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- 2014
47. Ambient air pollution and adult asthma incidence in six European cohorts (ESCAPE)
- Author
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Jacquemin, Bénédicte, Siroux, Valérie, Sanchez, Margaux, Carsin, Anne-Elie, Schikowski, Tamara, Adam, Martin, Bellisario, Valeria, Buschka, Anna, Bono, Roberto, Brunekreef, Bert, Cai, Yutong, Cirach, Marta, Clavel-Chapelon, Françoise, Declercq, Christophe, de Marco, Roberto, de Nazelle, Audrey, Ducret-Stich, Regina E, Ferretti, Virginia Valeria, Gerbase, Margaret W, Hardy, Rebecca, Heinrich, Joachim, Janson, Christer, Jarvis, Deborah, Al Kanaani, Zaina, Keidel, Dirk, Kuh, Diana, Le Moual, Nicole, Nieuwenhuijsen, Mark J, Marcon, Alessandro, Modig, Lars, Pin, Isabelle, Rochat, Thierry, Schindler, Christian, Sugiri, Dorothea, Stempfelet, Morgane, Temam, Sofia, Tsai, Ming-Yi, Varraso, Raphaëlle, Vienneau, Danielle, Vierkötter, Andrea, Hansell, Anna L, Krämer, Ursula, Probst-Hensch, Nicole M, Sunyer, Jordi, Künzli, Nino, Kauffmann, Francine, Dep IRAS, LS IRAS EEPI ME (Milieu epidemiologie), IRAS RATIA2, Risk Assessment of Toxic and Immunomodulatory Agents, Dep IRAS, LS IRAS EEPI ME (Milieu epidemiologie), IRAS RATIA2, and Risk Assessment of Toxic and Immunomodulatory Agents
- Subjects
Male ,Pediatrics ,Health, Toxicology and Mutagenesis ,Air pollution ,010501 environmental sciences ,medicine.disease_cause ,NO2 ,01 natural sciences ,0302 clinical medicine ,immune system diseases ,Medicine ,Prospective Studies ,Young adult ,Aged, 80 and over ,Air Pollutants ,Ambient air pollution ,Incidence (epidemiology) ,Incidence ,Public Health, Global Health, Social Medicine and Epidemiology ,Environmental exposure ,Middle Aged ,Adult ,Lung function ,Spirometry ,Europe ,Follow-Up Studies ,Humans ,Nitrogen Oxides ,Particulate Matter ,Environmental Exposure ,PM10 ,3. Good health ,Female ,medicine.medical_specialty ,03 medical and health sciences ,Young Adult ,Environmental health ,Asthma incidence ,Adverse effect ,0105 earth and related environmental sciences ,Asthma ,Aged ,business.industry ,Research ,Òxids de nitrogen -- Aspectes ambientals ,Public Health, Environmental and Occupational Health ,Asma -- Epidemiologia ,medicine.disease ,respiratory tract diseases ,Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi ,Logistic Models ,030228 respiratory system ,13. Climate action ,business - Abstract
Background Short-term exposure to air pollution has adverse effects among patients with asthma, but whether long-term exposure to air pollution is a cause of adult-onset asthma is unclear. Objective We aimed to investigate the association between air pollution and adult onset asthma. Methods Asthma incidence was prospectively assessed in six European cohorts. Exposures studied were annual average concentrations at home addresses for nitrogen oxides assessed for 23,704 participants (including 1,257 incident cases) and particulate matter (PM) assessed for 17,909 participants through ESCAPE land-use regression models and traffic exposure indicators. Meta-analyses of cohort-specific logistic regression on asthma incidence were performed. Models were adjusted for age, sex, overweight, education, and smoking and included city/area within each cohort as a random effect. Results In this longitudinal analysis, asthma incidence was positively, but not significantly, associated with all exposure metrics, except for PMcoarse. Positive associations of borderline significance were observed for nitrogen dioxide [adjusted odds ratio (OR) = 1.10; 95% CI: 0.99, 1.21 per 10 μg/m3; p = 0.10] and nitrogen oxides (adjusted OR = 1.04; 95% CI: 0.99, 1.08 per 20 μg/m3; p = 0.08). Nonsignificant positive associations were estimated for PM10 (adjusted OR = 1.04; 95% CI: 0.88, 1.23 per 10 μg/m3), PM2.5 (adjusted OR = 1.04; 95% CI: 0.88, 1.23 per 5 μg/m3), PM2.5absorbance (adjusted OR = 1.06; 95% CI: 0.95, 1.19 per 10–5/m), traffic load (adjusted OR = 1.10; 95% CI: 0.93, 1.30 per 4 million vehicles × meters/day on major roads in a 100-m buffer), and traffic intensity (adjusted OR = 1.10; 95% CI: 0.93, 1.30 per 5,000 vehicles/day on the nearest road). A nonsignificant negative association was estimated for PMcoarse (adjusted OR = 0.98; 95% CI: 0.87, 1.14 per 5 μg/m3). Conclusions Results suggest a deleterious effect of ambient air pollution on asthma incidence in adults. Further research with improved personal-level exposure assessment (vs. residential exposure assessment only) and phenotypic characterization is needed. Citation Jacquemin B, Siroux V, Sanchez M, Carsin AE, Schikowski T, Adam M, Bellisario V, Buschka A, Bono R, Brunekreef B, Cai Y, Cirach M, Clavel-Chapelon F, Declercq C, de Marco R, de Nazelle A, Ducret-Stich RE, Ferretti VV, Gerbase MW, Hardy R, Heinrich J, Janson C, Jarvis D, Al Kanaani Z, Keidel D, Kuh D, Le Moual N, Nieuwenhuijsen MJ, Marcon A, Modig L, Pin I, Rochat T, Schindler C, Sugiri D, Stempfelet M, Temam S, Tsai MY, Varraso R, Vienneau D, Vierkötter A, Hansell AL, Krämer U, Probst-Hensch NM, Sunyer J, Künzli N, Kauffmann F. 2015. Ambient air pollution and adult asthma incidence in six European cohorts (ESCAPE). Environ Health Perspect 123:613–621; http://dx.doi.org/10.1289/ehp.1408206
- Published
- 2014
48. Human leukocyte antigen class II variants and adult-onset asthma: does occupational allergen exposure play a role?
- Author
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Smit, Lidwien A. M. Strachan, David P. Vermeulen, Roel de Bakker, Paul I. W. Demenais, Florence Dumas, Orianne Carsin, Anne-Elie Cullinan, Paul Curjuric, Ivan Ghosh, Rebecca E. and Heederik, Dick Imboden, Medea Jarvis, Deborah Lathrop, Mark Le Moual, Nicole Mehta, Amar Miedinger, David and Sigsgaard, Torben Siroux, Valerie Vernez, David Paul Zock, Jan Kauffmann, Francine Probst-Hensch, Nicole Kogevinas, Manolis Bouzigon, Emmanuelle
- Subjects
immune system diseases ,respiratory tract diseases - Abstract
Recently, a locus centred on rs9273349 in the HLA-DQ region emerged from genome-wide association studies of adult-onset asthma. We aimed to further investigate the role of human leukocyte antigen (HLA) class II in adult-onset asthma and a possible interaction with occupational exposures. We imputed classical HLA-II alleles from 7579 single-nucleotide polymorphisms in 6025 subjects (1202 with adult-onset asthma) from European cohorts: ECRHS, SAPALDIA, EGEA and B58C, and from surveys of bakers and agricultural workers. Based on an asthma-specific job exposure matrix, 2629 subjects had ever been exposed to high molecular weight (HMW) allergens. We explored associations between 23 common HLA-II alleles and adult-onset asthma, and tested for gene environment interaction with occupational exposure to HMW allergens. Interaction was also tested for rs9273349. Marginal associations of classical HLA-II alleles and adult-onset asthma were not statistically significant. Interaction was detected between the DPB1(star)03:01 allele and exposure to HMW allergens (p=0.009), in particular to latex (p=0.01). In the unexposed group, the DPB1(star)03:01 allele was associated with adult-onset asthma (OR 0.67, 95%CI 0.53-0.86). HMW allergen exposures did not modify the association of rs9273349 with adult-onset asthma. Common classical HLA-II alleles were not marginally associated with adult-onset asthma. The association of latex exposure and adult-onset asthma may be modified by DPB1(star)03:01.
- Published
- 2014
49. Occupational exposures and uncontrolled adult-onset asthma in the European Community Respiratory Health Survey II
- Author
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Le Moual, Nicole Carsin, Anne-Elie Siroux, Valerie Radon, Katja Norback, Dan Toren, Kjell Olivieri, Mario Urrutia, Isabel Cazzoletti, Lucia Jacquemin, Benedicte Benke, Geza and Kromhout, Hans Mirabelli, Maria C. Mehta, Amar J. and Schluenssen, Vivi Sigsgaard, Torben Blanc, Paul D. and Kogevinas, Manolis Anto, Josep M. Zock, Jan-Paul
- Subjects
respiratory tract diseases - Abstract
Occupational exposure is a well-recognised modifiable risk factor for asthma, but the relationship between occupational exposure and asthma control has not been studied. We aimed to study this association among working-age adults from the European Community Respiratory Health Survey (ECRHS). Data were available for 7077 participants (mean age 43 years, 45% never-smokers, 5867 without asthma and 1210 with current asthma). Associations between occupational exposure to specific asthmagens and asthma control status (33% with uncontrolled asthma, based on the Global Initiative for Asthma guidelines) were evaluated using logistic and multinomial regressions, adjusted for age, sex and smoking status, with study areas included as a random effect. Statistically significant positive associations were observed between uncontrolled adult-onset asthma and both past 12-month and 10-year exposure to any occupational asthmagens (OR (95% CI) 1.6 (1.0-2.40) and 1.7 (1.2-2.5), respectively); high (1.7 (1.0-2.8) and 1.9 (1.3-2.9), respectively) and low (1.6 (1.0-2.7) and 1.8 (1.2-2.7), respectively) molecular weight agents; and cleaning agents (2.0 (1.1-3.6) and 2.3 (1.4-3.6), respectively), with stronger associations for long-term exposures. These associations were mainly explained by the exacerbation domain of asthma control and no associations were observed between asthmagens and partly controlled asthma. These findings suggest that occupational exposure to asthmagens is associated with uncontrolled adult-onset asthma. Occupational risk factors should be quickly identified to prevent uncontrolled asthma.
- Published
- 2014
50. Prenatal Ambient Air Pollution, Placental Mitochondrial DNA Content, and Birth Weight in the INMA (Spain) and ENVIR ON AGE (Belgium) Birth Cohorts
- Author
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Clemente, Diana B.P., primary, Casas, Maribel, additional, Vilahur, Nadia, additional, Begiristain, Haizea, additional, Bustamante, Mariona, additional, Carsin, Anne-Elie, additional, Fernández, Mariana F., additional, Fierens, Frans, additional, Gyselaers, Wilfried, additional, Iñiguez, Carmen, additional, Janssen, Bram G., additional, Lefebvre, Wouter, additional, Llop, Sabrina, additional, Olea, Nicolás, additional, Pedersen, Marie, additional, Pieters, Nicky, additional, Santa Marina, Loreto, additional, Souto, Ana, additional, Tardón, Adonina, additional, Vanpoucke, Charlotte, additional, Vrijheid, Martine, additional, Sunyer, Jordi, additional, and Nawrot, Tim S., additional
- Published
- 2016
- Full Text
- View/download PDF
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