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1. Anatomical Variations in Pulmonary Arterial Branches in Patients Undergoing Evaluation for Chronic Thromboembolic Pulmonary Hypertension

Author

Michaud, Erinleigh, Pan, Michael, Lakhter, Vladimir, Reddy Maligireddy, Anand, Hyder, Syed N., Patel, Nimai, Moles, Victor M., McLaughlin, Vallerie V., Agarwal, Prachi P., Visovatti, Scott H., Cascino, Thomas M., Haft, Jonathan, Rosenfield, Kenneth, Nallamothu, Brahmajee K., Giri, Jay S., Bashir, Riyaz, and Aggarwal, Vikas

Published
2023
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10. Comorbid Conditions and Health-Related Quality of Life in Ambulatory Heart Failure Patients: REVIVAL (Registry Evaluation of Vital Information for VADs in Ambulatory Life REVIVAL)

Author

Cascino, Thomas M., Kittleson, Michelle M., Lala, Anuradha, Stehlik, Josef, Palardy, Maryse, Pamboukian, Salpy V., Ewald, Gregory A., Mountis, Maria M., Horstmanshof, Douglas A., Robinson, Shawn W., Shah, Palak, Jorde, Ulrich P., McLean, Rhondalyn C., Richards, Blair, Khalatbari, Shokoufeh, Spino, Cathie, Taddei-Peters, Wendy C., Grady, Kathleen L., Mann, Douglas L., Stevenson, Lynne W., Stewart, Garrick C., and Aaronson, Keith D.

Published
2020
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11. Preoperative clinical diagnostic accuracy of heart failure among patients undergoing major noncardiac surgery: a single-centre prospective observational analysis

Author

Golbus, Jessica R., primary, Joo, Hyeon, additional, Janda, Allison M., additional, Maile, Michael D., additional, Aaronson, Keith D., additional, Engoren, Milo C., additional, Cassidy, Ruth B., additional, Kheterpal, Sachin, additional, Mathis, Michael R., additional, Mentz, Graciela B., additional, Nallamothu, Brahmajee K., additional, Pagani, Francis D., additional, Likosky, Donald S., additional, and Cascino, Thomas M., additional

Published
2022
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12. Role of the mitral valve in left ventricular assist device pathophysiology

Author

Noly, Pierre-Emmanuel, primary, Duggal, Neal, additional, Jiang, Mulan, additional, Nordsletten, David, additional, Bonini, Mia, additional, Lei, Ienglam, additional, Ela, Ashraf Abou El, additional, Haft, Jonathan W., additional, Pagani, Francis D., additional, Cascino, Thomas M., additional, and Tang, Paul C., additional

Published
2022
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13. Generalizability of Trial Data to Real-World Practice: An Analysis of The Society of Thoracic Surgeons Intermacs Database

Author

Brescia, Alexander A., primary, Watt, Tessa M.F., additional, Pagani, Francis D., additional, Cascino, Thomas M., additional, Zhang, Min, additional, McCullough, Jeffrey S., additional, Shore, Supriya, additional, Likosky, Donald S., additional, Aaronson, Keith D., additional, Cantor, Ryan S., additional, Deng, Luqin, additional, Kirklin, James K., additional, and Thompson, Michael P., additional

Published
2022
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14. Racial and Sex Inequities in the Use of and Outcomes After Left Ventricular Assist Device Implantation Among Medicare Beneficiaries

Author

Cascino, Thomas M., primary, Somanchi, Sriram, additional, Colvin, Monica, additional, Chung, Grace S., additional, Brescia, Alexander A., additional, Pienta, Michael, additional, Thompson, Michael P., additional, Stewart, James W., additional, Sukul, Devraj, additional, Watkins, Daphne C., additional, Pagani, Francis D., additional, Likosky, Donald S., additional, Aaronson, Keith D., additional, and McCullough, Jeffrey S., additional

Published
2022
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15. Advancing Quality Metrics for Durable Left Ventricular Assist Device Implant: Analysis of the Society of Thoracic Surgeons Intermacs Database

Author

Pienta, Michael J., primary, Wu, Xiaoting, additional, Cascino, Thomas M., additional, Brescia, Alexander A., additional, Abou el Ela, Ashraf, additional, Zhang, Min, additional, McCullough, Jeffrey S., additional, Shore, Supriya, additional, Aaronson, Keith D., additional, Thompson, Michael P., additional, Pagani, Francis D., additional, and Likosky, Donald S., additional

Published
2022
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16. Failure to rescue: A candidate quality metric for durable left ventricular assist device implantation

Author

Pienta, Michael J., primary, Cascino, Thomas M., additional, Likosky, Donald S., additional, Ghaferi, Amir A., additional, Aaronson, Keith D., additional, Pagani, Francis D., additional, Thompson, Michael P., additional, El Ela, Ashraf Shaaban Abdel Aziz Abou, additional, Tang, Paul C., additional, Aaronson, Keith, additional, Shore, Supriya, additional, Cascino, Thomas, additional, Salciccioli, Katherine B., additional, Zhang, Min, additional, McCullough, Jeffrey S., additional, Hou, Michelle, additional, Janda, Allison M., additional, Mathis, Michael R., additional, Watt, Tessa M.F., additional, Pienta, Michael J., additional, Brescia, Alexander, additional, Airhart, Austin, additional, Liesman, Daniel, additional, and Nassar, Khalil, additional

Published
2021
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17. At a crossroads: COVID-19 recovery and the risk of pulmonary vascular disease

Author

Cascino, Thomas M., Desai, Ankit A., and Kanthi, Yogendra

Subjects
Lung Diseases, Pulmonary Circulation, SARS-CoV-2, COVID-19, Humans, Vascular Diseases, Pandemics, Article
Abstract

PURPOSE OF REVIEW: The coronavirus disease 2019 (COVID-19) pandemic has led to almost 3,000,000 deaths across 139 million people infected worldwide. Involvement of the pulmonary vasculature is considered a major driving force for morbidity and mortality. We set out to summarize current knowledge on acute manifestations of pulmonary vascular disease (PVD) resulting from COVID-19 and prioritize long-term complications that may impact pulmonary hypertension (PH). RECENT FINDINGS: Acute COVID-19 infection can result in widespread involvement of the pulmonary vasculature, myocardial injury, evidence of persistent lung disease, and venous thromboembolism. Post COVID-19 survivors frequently report ongoing symptoms and may be at risk for the spectrum of PH, including group 1 pulmonary arterial hypertension, group 2 PH due to left heart disease, group 3 PH due to lung disease and/or hypoxia, and group 4 chronic thromboembolic PH. SUMMARY: The impact of COVID-19 on the pulmonary vasculature is central to determining disease severity. While the long-term PVD manifestations of COVID-19 are currently uncertain, optimizing the care of risk factors for PH and monitoring for the development of PVD will be critical to reducing long-term morbidity and improving the health of survivors.

Published
2021

19. Comorbid Conditions and Health-related Quality of Life in Ambulatory Heart Failure Patients: A Report from REVIVAL

Author

Cascino, Thomas M., Kittleson, Michelle M., Lala, Anuradha, Stehlik, Josef, Palardy, Maryse, Pamboukian, Salpy V., Ewald, Gregory A., Mountis, Maria M., Horstmanshof, Douglas A., Robinson, Shawn W., Shah, Palak, Jorde, Ulrich P., McLean, Rhondalyn C., Richards, Blair, Khalatbari, Shokoufeh, Spino, Cathie, Taddei-Peters, Wendy C., Grady, Kathleen L., Mann, Douglas L., Stevenson, Lynne W., Stewart, Garrick C., and Aaronson, Keith D.

Subjects
Heart Failure, Male, Depression, Health Status, Comorbidity, Middle Aged, Risk Assessment, humanities, Article, United States, Prosthesis Implantation, Cross-Sectional Studies, Treatment Outcome, Risk Factors, Prevalence, Quality of Life, Humans, Female, Heart-Assist Devices, Prospective Studies, Registries, Aged
Abstract

BACKGROUND: Patients with heart failure (HF) often have multiple chronic conditions that may impact health-related quality of life (HRQOL) despite HF therapy. We sought to determine the association between noncardiac comorbidities and HRQOL in ambulatory patients with advanced HF. METHODS: Baseline data from 373 subjects in Registry Evaluation of Vital Information for Ventricular Assist Devices (VADs) in Ambulatory Life were analyzed using multivariable general linear models to evaluate the relationship between comorbidities and HRQOL (EuroQol-visual analogue scale [EQ-VAS], EQ-5D-3L Index Score, and Kansas City Cardiomyopathy Questionnaire [KCCQ]). The primary independent variables were a comorbidity index (sum of 14 noncardiac conditions), a residual comorbidity index (without depression), and depression alone. The median (25(th)-75(th) percentile) number of comorbidities was 3 (2–4). RESULTS: Increasing comorbidity burden was associated with a reduction in generic (EQ-5D Index, p=0.005) and HF-specific (KCCQ, p=0.001) HRQOL. The residual comorbidity index was not associated with HRQOL when depression included in the model independently, while depression was associated with HRQOL across all measures. Participants with depression (vs. without) scored on average 13 points (95% confidence interval 8–17) lower on the EQ-VAS, 0.15 points (0.12–0.18) lower on the EQ-5D Index, and 24.9 points (21.2–28.5) lower on the KCCQ-overall summary score. CONCLUSIONS: While noncardiac comorbidities were prevalent in ambulatory advanced HF patients, only depression was associated with decreased generic and HF-specific HRQOL. Other than depression, the presence of noncardiac comorbidities should not impact expected gains in HRQOL following VAD, provided the conditions are not a contraindication to implant. REGISTRATION: Clinicaltrials.gov; Unique identifier: NCT01369407.

Published
2020

20. sj-pdf-1-pul-10.1177_2045894020974926 - Supplemental material for Impact of patient characteristics and perceived barriers on referral to exercise rehabilitation among patients with pulmonary hypertension in the United States

Author

Cascino, Thomas M., Ashur, Carmel, Richardson, Caroline R., Jackson, Elizabeth A., and Vallerie V. McLaughlin

Subjects
110203 Respiratory Diseases, FOS: Clinical medicine, Cardiology
Abstract

Supplemental material, sj-pdf-1-pul-10.1177_2045894020974926 for Impact of patient characteristics and perceived barriers on referral to exercise rehabilitation among patients with pulmonary hypertension in the United States by Thomas M. Cascino, Carmel Ashur, Caroline R. Richardson, Elizabeth A. Jackson and Vallerie V. McLaughlin in Pulmonary Circulation

Published
2020
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25. Racial Inequities in Access to Ventricular Assist Device and Transplant Persist After Consideration for Preferences for Care: A Report From the REVIVAL Study.

Author

Cascino, Thomas M., Colvin, Monica M., Lanfear, David E., Richards, Blair, Khalatbari, Shokoufeh, Mann, Douglas L., Taddei-Peters, Wendy C., Jeffries, Neal, Watkins, Daphne C., Stewart, Garrick C., and Aaronson, Keith D.

Abstract

Background: Racial disparities in access to advanced therapies for heart failure (HF) patients are well documented, although the reasons remain uncertain. We sought to determine the association of race on utilization of ventricular assist device (VAD) and transplant among patients with access to care at VAD centers and if patient preferences impact the effect. Methods: We performed an observational cohort study of ambulatory chronic systolic HF patients with high-risk features and no contraindication to VAD enrolled at 21 VAD centers and followed for 2 years in the REVIVAL study (Registry Evaluation of Vital Information for VADs in Ambulatory Life). We used competing events cause-specific proportional hazard methodology with multiple imputation for missing data. The primary outcomes were (1) VAD/transplant and (2) death. The exposures of interest included race (Black or White), additional demographics, captured social determinants of health, clinician-assessed HF severity, patient-reported quality of life, preference for VAD, and desire for therapies. Results: The study included 377 participants, of whom 100 (26.5%) identified as Black. VAD or transplant was performed in 11 (11%) Black and 62 (22%) White participants, although death occurred in 18 (18%) Black and 36 (13%) White participants. Black race was associated with reduced utilization of VAD and transplant (adjusted hazard ratio, 0.45 [95% CI, 0.23–0.85]) without an increase in death. Preferences for VAD or life-sustaining therapies were similar by race and did not explain racial disparities. Conclusions: Among patients receiving care by advanced HF cardiologists at VAD centers, there is less utilization of VAD and transplant for Black patients even after adjusting for HF severity, quality of life, and social determinants of health, despite similar care preferences. This residual inequity may be a consequence of structural racism and discrimination or provider bias impacting decision-making. Registration: URL: https://www.clinicaltrials.gov; Unique identifier: NCT01369407. [ABSTRACT FROM AUTHOR]

Published
2023
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26. Comparison of Evaluations for Heart Transplant Before Durable Left Ventricular Assist Device and Subsequent Receipt of Transplant at Transplant vs Nontransplant Centers.

Author

Cascino, Thomas M., McCullough, Jeffrey S., Wu, Xiaoting, Pienta, Michael J., Stewart II, James W., Hawkins, Robert B., Brescia, Alexander A., Abou el ala, Ashraf, Zhang, Min, Noly, Pierre-Emmanuel, Haft, Jonathan W., Cowger, Jennifer A., Colvin, Monica, Aaronson, Keith D., Pagani, Francis D., and Likosky, Donald S.

Published
2022
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