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6. Multicentric evaluation of BioFire FilmArray Pneumonia Panel for rapid bacteriological documentation of pneumonia

Author

Alviset, Sophie, Armand-Lefèvre, Laurence, Baldeyrou, Marion, Becker, Agathe, Boibieux, André, Bonacorsi, Stéphane, Burucoa, Christophe, Cambau, Emmanuelle, Casalegno, Jean-Sébastien, Cointe, Aurélie, Cremniter, Julie, Destras, Grégory, Duquaire, Paul, Geslain, Guillaume, Gustave, Claude-Alexandre, Jacquier, Hervé, Kouatchet, Achille, Lecorche, Emmanuel, Lejeune, Manon, Lina, Bruno, Mahieu, Rafaël, Maamar, Adel, Michaud, Anthony, Monnard, Céline, Montravers, Philippe, Neuwirth, Catherine, Péan de Ponfilly, Gauthier, Pichon, Maxime, Plouzeau, Chloé, Poyart, Claire, Quenot, Jean-Pierre, Rzepecki, Vincent, Stéphan, Robin, Timsit, Jean-François, Tran-Dinh, Alexy, Vandenesch, François, Vigier, Emmanuelle, Gastli, Nabil, Loubinoux, Julien, Daragon, Matthieu, Lavigne, Jean-Philippe, Saint-Sardos, Pierre, Pailhoriès, Hélène, Lemarié, Carole, Benmansour, Hanaa, d’Humières, Camille, Broutin, Lauranne, Dauwalder, Olivier, Levy, Michael, Auger, Gabriel, Kernéis, Solen, and Cattoir, Vincent

Published
2021
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7. Cerebral nocardiosis in a patient treated with pembrolizumab: a first case report

Author

Petitgas Paul, Lesouhaitier Mathieu, Boukthir Sarrah, Cattoir Vincent, Tattevin Pierre, and Bénézit François

Subjects
Nocardiosis, Pembrolizumab, IRAE, Case report, Infectious and parasitic diseases, RC109-216
Abstract

Abstract Background Checkpoints inhibitors (CPIs) are increasingly used for the treatment of several malignancies. The most common side effects are Immune Related Adverse Events, while infectious complications are rare, especially cerebral nocardiosis. Case presentation Here, we report the first clinical case of a cerebral nocardiosis revealed after seizure in a patient treated by pembrolizumab for a metastatic lung cancer, in the absence of any additional immunosuppressive therapy or risk factors for cerebral nocardiosis. The extended evaluation including a brain CT-scan did not reveal any lesion before pembrolizumab. Nevertheless, the 3-month delay between the start of Pembrolizumab and the diagnosis of cerebral nocardiosis suggests that the infection occurred prior to the CPI. Unfortunately, the patient died during treatment for cerebral nocardiosis, while the lung cancer tumor mass had decreased by 80% after the sixth cycle of pembrolizumab. Conclusions This case report emphasizes that clinicians should consider diagnoses other than metastasis in a patient with a brain mass and metastatic cancer treated with CPI, such as opportunistic infections or IRAE.

Published
2022
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16. Evaluation of ceftolozane-tazobactam susceptibility on a French nationwide collection of Enterobacterales

Author

Jousset, Agnès B., primary, Bernabeu, Sandrine, additional, Emeraud, Cécile, additional, Bonnin, Rémy A., additional, Lomont, Alexandra, additional, Zahar, Jean Ralph, additional, Merens, Audrey, additional, Isnard, Christophe, additional, Soismier, Nathalie, additional, Farfour, Eric, additional, Fihman, Vincent, additional, Yin, Nicolas, additional, Barraud, Olivier, additional, Jacquier, Hervé, additional, Ranc, Anne-Gaëlle, additional, Laurent, Frédéric, additional, Corvec, Stéphane, additional, d'Epenoux, Louise Ruffier, additional, Bille, Emmanuelle, additional, Degand, Nicolas, additional, Plouzeau, Chloé, additional, Guillard, Thomas, additional, Cattoir, Vincent, additional, Mizrahi, Asaf, additional, Grillon, Antoine, additional, Janvier, Frédéric, additional, Brun, Cécile Le, additional, Amara, Marlène, additional, Bastide, Mathilda, additional, Lemonnier, Alban, additional, and Dortet, Laurent, additional

Published
2023
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17. Synergistic Activity of Pep16, a Promising New Antibacterial Pseudopeptide against Multidrug-Resistant Organisms, in Combination with Colistin against Multidrug-Resistant Escherichia coli, In Vitro and in a Murine Peritonitis Model

Author

Chosidow, Samuel, primary, Fantin, Bruno, additional, Nicolas, Irène, additional, Mascary, Jean-Baptiste, additional, Chau, Françoise, additional, Bordeau, Valérie, additional, Verdier, Marie-Clemence, additional, Rocheteau, Pierre, additional, Guérin, Francois, additional, Cattoir, Vincent, additional, and de Lastours, Victoire, additional

Published
2023
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19. Exploring Cluster-Dependent Antibacterial Activities and Resistance Pathways of NOSO-502 and Colistin against Enterobacter cloacae Complex Species

Author

Pantel, Lucile, primary, Guérin, François, additional, Serri, Marine, additional, Gravey, François, additional, Houard, Jessica, additional, Maurent, Kelly, additional, Attwood, Marie, additional, Noel, Alan, additional, MacGowan, Alasdair, additional, Racine, Emilie, additional, Cattoir, Vincent, additional, and Gualtieri, Maxime, additional

Published
2022
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20. Impact of Enterococcus faecalis endocarditis treatment on risk of relapse

Author

Danneels, Pierre, Hamel, Jean François, Picard, Léa, Rezig, Schéhérazade, Martinet, Pauline, Lorleac’h, Aurélien, Talarmin, Jean Philippe, Buzelé, Rodolphe, Guimard, Thomas, Le Moal, Gwenaël, Brochard-Libois, Julia, Beaudron, Aurélie, Letheulle, Julien, Codde, Cyrielle, Chenouard, Rachel, Boutoille, David, Lemaignen, Adrien, Bernard, Louis, Cattoir, Vincent, Dubée, Vincent, Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), Hôpital Pontchaillou, Hôpital de la Cavale Blanche, Groupe Hospitalier Bretagne Sud (GHBS), Centre Hospitalier Intercommunal de Cornouaille (CHIC), CHU de Saint-Brieuc, Centre Hospitalier Départemental - Hôpital de La Roche-sur-Yon (CHD Vendée), Centre hospitalier universitaire de Poitiers (CHU Poitiers), Centre hospitalier de Saint-Nazaire, Centre Hospitalier Le Mans (CH Le Mans), Centre Hospitalier de Laval (CH Laval), CHU Limoges, Centre d'investigation clinique (CIC) de Nantes -CIC Plurithématique (CIC 0004 - Nantes), Direction Générale de l'Organisation des Soins (DGOS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre hospitalier universitaire de Nantes (CHU Nantes), Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), ARN régulateurs bactériens et médecine (BRM), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Immunology and New Concepts in ImmunoTherapy (INCIT), Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Centre d’Investigation Clinique de Nantes (CIC Nantes), Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre hospitalier universitaire de Nantes (CHU Nantes), and Pecqueret, Valérie

Subjects
Microbiology (medical), [SDV] Life Sciences [q-bio], Infectious Diseases, Drug Therapy, Endocarditis, E. faecalis, [SDV]Life Sciences [q-bio], Combination, Amoxicillin, Relapse
Abstract

Background Enterococcus faecalis infective endocarditis (EFIE) is characterized by a higher frequency of relapses than other infective endocarditis. The role of the treatment on its occurrence remains poorly understood. The aim of this study was to investigate whether the antibiotic regimen could impact the risk of relapse in EFIE. Materials This was a multicenter retrospective study of patients diagnosed with definite EFIE between 2015 and 2019 in 14 French hospitals. The primary endpoint was the occurrence of relapses within the year following endocarditis diagnosis. As death was a competing risk for relapse, Fine and Gray models were used for studying risk factors and impact of treatment. Results Of the 279 patients included, 83 (29.7%) received the amoxicillin-gentamicin (A-G) combination, 114 (40.9%) amoxicillin-ceftriaxone (A-C), 63 (22.6%) A-G and A-C (A-G/A-C) sequentially, 9 (3.2%) amoxicillin (A), and 10 received other treatments. One-year-relapse rate was 9.3% (26 patients). Relapse occurred after a median delay of 107 days from EFIE diagnosis; 6 occurred after 6 months, and 6 were diagnosed by blood cultures in asymptomatic patients. In multivariate analysis, surgery during treatment was a protective factor against one-year relapse and death. The cumulative incidence of relapse 1 year after endocarditis was 46.2% for patients treated with amoxicillin, 13.4% with A-G, 14.7% with A-C, and 4.3% with A-G/A-C (P≥.05 in multivariate analysis). Conclusions Relapses after treatment of EFIE are frequent, frequently asymptomatic, and may occur more than 6 months after the initial episode.

Published
2022

22. Discrimination of Escherichia coli, Shigella flexneri, and Shigella sonnei using lipid profiling by MALDI‐TOF mass spectrometry paired with machine learning

Author

Pizzato, Jade, primary, Tang, Wenhao, additional, Bernabeu, Sandrine, additional, Bonnin, Rémy A., additional, Bille, Emmanuelle, additional, Farfour, Eric, additional, Guillard, Thomas, additional, Barraud, Olivier, additional, Cattoir, Vincent, additional, Plouzeau, Chloe, additional, Corvec, Stéphane, additional, Shahrezaei, Vahid, additional, Dortet, Laurent, additional, and Larrouy‐Maumus, Gerald, additional

Published
2022
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26. Efficient and Quality-Optimized Metagenomic Pipeline Designed for Taxonomic Classification in Routine Microbiological Clinical Tests

Author

Buffet-Bataillon, Sylvie, Rizk, Guillaume, Cattoir, Vincent, Sassi, Mohamed, Thibault, V., del Giudice, Jennifer, Gangneux, Jean-Pierre, Nutrition, Métabolismes et Cancer (NuMeCan), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Illumina, ARN régulateurs bactériens et médecine (BRM), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), CHU Pontchaillou [Rennes], Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Région Bretagne, France, for financial support (Appel à projet 'Transfert de technologies des filières Santé et Biotechnologies' 2018 to J. Del Giudice and to J.P. Gangneux), and Jonchère, Laurent

Subjects
[SDV] Life Sciences [q-bio], metagenomics, mycobiome, virome, Bracken, quality assessment, shotgun, [SDV]Life Sciences [q-bio], Kraken2, microbiome, Kaiju, clinical microbiology
Abstract

International audience; Metagenomics analysis is now routinely used for clinical diagnosis in several diseases, and we need confidence in interpreting metagenomics analysis of microbiota. Particularly from the side of clinical microbiology, we consider that it would be a major milestone to further advance microbiota studies with an innovative and significant approach consisting of processing steps and quality assessment for interpreting metagenomics data used for diagnosis. Here, we propose a methodology for taxon identification and abundance assessment of shotgun sequencing data of microbes that are well fitted for clinical setup. Processing steps of quality controls have been developed in order (i) to avoid low-quality reads and sequences, (ii) to optimize abundance thresholds and profiles, (iii) to combine classifiers and reference databases for best classification of species and abundance profiles for both prokaryotic and eukaryotic sequences, and (iv) to introduce external positive control. We find that the best strategy is to use a pipeline composed of a combination of different but complementary classifiers such as Kraken2/Bracken and Kaiju. Such improved quality assessment will have a major impact on the robustness of biological and clinical conclusions drawn from metagenomic studies.

Published
2022

27. Synovial calprotectin: A potentially useful biomarker for the diagnosis of Kingella kingae native arthritis.

Author

Leroy, Anne‐Gallë, Bémer, Pascale, Decante, Cyrille, Ruffier d'Epenoux, Louise, Tessier, Eve, Crenn, Vincent, Guillouzouic, Aurélie, Corvec, Stéphane, Tandé, Didier, Gougeon, Anne, Cattoir, Vincent, Plouzeau, Chloé, Lemarié, Carole, Chenouard, Racheal, and Lartigue, Marie‐Frédérique

Subjects
CALPROTECTIN, SYNOVIAL fluid, ARTHRITIS, BIOMARKERS, INFECTIOUS arthritis, DIAGNOSIS
Abstract

Kingella kingae is a bacteria involved in developing arthritis in children. Its diagnosis remains difficult. We report a case for which a new biomarker, calprotectin measured in the synovial fluid, was strongly positive and a specific molecular test was the only way to diagnose it specifically. Kingella kingae remains as a common etiology of child arthritis. Its growth is sometime difficult. Even if synovial fluid (SF) culture in blood bottle or SF‐specific K. kingae PCR have improved the diagnosis, a new biomarker such as calprotectin may be useful for the diagnosis. [ABSTRACT FROM AUTHOR]

Published
2023
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28. The Association Between Antibiotic Use and Outcome Among Metastatic Melanoma Patients Receiving Immunotherapy

Author

Poizeau, Florence, primary, Kerbrat, Sandrine, additional, Balusson, Frédéric, additional, Tattevin, Pierre, additional, Revest, Matthieu, additional, Cattoir, Vincent, additional, Luque-Paz, David, additional, Lesimple, Thierry, additional, Pracht, Marc, additional, Dinulescu, Monica, additional, Russo, David, additional, Oger, Emmanuel, additional, and Dupuy, Alain, additional

Published
2022
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30. Beneficial effects of citrulline enteral administration on sepsis-induced T cell mitochondrial dysfunction

Author

Reizine, Florian, primary, Grégoire, Murielle, additional, Lesouhaitier, Mathieu, additional, Coirier, Valentin, additional, Gauthier, Juliette, additional, Delaloy, Céline, additional, Dessauge, Elise, additional, Creusat, Florent, additional, Uhel, Fabrice, additional, Gacouin, Arnaud, additional, Dessauge, Frédéric, additional, Le Naoures, Cécile, additional, Moreau, Caroline, additional, Bendavid, Claude, additional, Daniel, Yoann, additional, Petitjean, Kilian, additional, Bordeau, Valérie, additional, Lamaison, Claire, additional, Piau, Caroline, additional, Cattoir, Vincent, additional, Roussel, Mikael, additional, Fromenty, Bernard, additional, Michelet, Christian, additional, Le Tulzo, Yves, additional, Zmijewski, Jaroslaw, additional, Thibault, Ronan, additional, Cogné, Michel, additional, Tarte, Karin, additional, and Tadié, Jean-Marc, additional

Published
2022
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31. High Prevalence of OXA-23 Carbapenemase-Producing Proteus mirabilis among Amoxicillin-Clavulanate-Resistant Isolates in France

Author

Lombes, Amélie, primary, Bonnin, Rémy A., additional, Laurent, Frédéric, additional, Guet-Revillet, Hélène, additional, Bille, Emmanuelle, additional, Cattoir, Vincent, additional, Fangous, Marie-Sarah, additional, Le Brun, Cécile, additional, Fihman, Vincent, additional, Janvier, Frédéric, additional, Otto, Marie-Pierre, additional, Potron, Anais, additional, Corvec, Stéphane, additional, Ruffier d’Epenoux, Louise, additional, Mizrahi, Assaf, additional, and Dortet, Laurent, additional

Published
2022
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35. In Vitro Antimicrobial Susceptibility Profiles of Gram-Positive Anaerobic Cocci Responsible for Human Invasive Infections

Author

Guérin, François, Dejoies, Loren, Degand, Nicolas, Guet-Revillet, Hélène, Janvier, Frédéric, Corvec, Stéphane, Barraud, Olivier, Guillard, Thomas, Walewski, Violaine, Gallois, Emmanuelle, Cattoir, Vincent, Group, on behalf of the GMC Study, CHU Pontchaillou [Rennes], Centre Hospitalier Universitaire de Nice (CHU Nice), Hôpital Purpan [Toulouse], CHU Toulouse [Toulouse], Hopital d'instruction des armées Sainte-Anne [Toulon] (HIA), Centre hospitalier universitaire de Nantes (CHU Nantes), Hôpital Dupuytren [CHU Limoges], Centre Hospitalier Universitaire de Reims (CHU Reims), Groupe Hospitalier Hôpitaux Universitaires Paris Seine-Saint-Denis [Bobigny] (GH HUPSSD), Institut Gustave Roussy (IGR), Microbiologie, Département de biologie et pathologie médicales [Gustave Roussy], Institut Gustave Roussy (IGR)-Institut Gustave Roussy (IGR), ARN régulateurs bactériens et médecine (BRM), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), This research received no external funding., dormoy, valerian, Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), and Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )

Subjects
Microbiology (medical), Peptoniphilus, Imipenem, food.ingredient, Cefotaxime, QH301-705.5, [SDV]Life Sciences [q-bio], ved/biology.organism_classification_rank.species, Biology, Microbiology, Article, 03 medical and health sciences, food, Parvimonas micra, Virology, medicine, polycyclic compounds, antimicrobial resistance, Biology (General), 030304 developmental biology, 0303 health sciences, 030306 microbiology, ved/biology, Peptostreptococcus anaerobius, GPAC, Clindamycin, Anaerococcus, Amoxicillin, biochemical phenomena, metabolism, and nutrition, bacterial infections and mycoses, Finegoldia magna, 3. Good health, [SDV] Life Sciences [q-bio], medicine.drug, Piperacillin
Abstract

The aim of this multicentre study was to determine the in vitro susceptibility to anti-anaerobic antibiotics of Gram-positive anaerobic cocci (GPAC) isolates responsible for invasive infections in humans. A total of 133 GPAC isolates were collected in nine French hospitals from 2016 to 2020. All strains were identified to the species level (MALDI-TOF mass spectrometry, 16S rRNA sequencing). Minimum inhibitory concentrations (MICs) of amoxicillin, piperacillin, cefotaxime, imipenem, clindamycin, vancomycin, linezolid, moxifloxacin, rifampicin, and metronidazole were determined by the reference agar dilution method. Main erm-like genes were detected by PCR. The 133 GPAC isolates were identified as follows: 10 Anaerococcus spp., 49 Finegoldia magna, 33 Parvimonas micra, 30 Peptoniphilus spp., and 11 Peptostreptococcus anaerobius. All isolates were susceptible to imipenem, vancomycin (except 3 P. micra), linezolid and metronidazole. All isolates were susceptible to amoxicillin and piperacillin, except for P. anaerobius (54% and 45% susceptibility only, respectively). MICs of cefotaxime widely varied while activity of rifampicin, and moxifloxacin was also variable. Concerning clindamycin, 31 were categorized as resistant (22 erm(A) subclass erm(TR), 7 erm(B), 1 both genes and 1 negative for tested erm genes) with MICs from 8 to &gt, 32 mg/L. Although GPACs are usually susceptible to drugs commonly used for the treatment of anaerobic infections, antimicrobial susceptibility should be evaluated in vitro.

Published
2021
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37. Rapid Detection of VanA/B-Producing Vancomycin-Resistant Enterococci Using Lateral Flow Immunoassay

Author

Oueslati, Saoussen, primary, Gonzalez, Camille, additional, Volland, Hervé, additional, Cattoir, Vincent, additional, Bernabeu, Sandrine, additional, Girlich, Delphine, additional, Dulac, Duncan, additional, Plaisance, Marc, additional, Boutigny, Laure, additional, Dortet, Laurent, additional, Simon, Stéphanie, additional, and Naas, Thierry, additional

Published
2021
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39. Multicentric evaluation of BioFire FilmArray Pneumonia Panel for rapid bacteriological documentation of pneumonia

Author

Gastli, Nabil, primary, Loubinoux, Julien, additional, Daragon, Matthieu, additional, Lavigne, Jean-Philippe, additional, Saint-Sardos, Pierre, additional, Pailhoriès, Hélène, additional, Lemarié, Carole, additional, Benmansour, Hanaa, additional, d’Humières, Camille, additional, Broutin, Lauranne, additional, Dauwalder, Olivier, additional, Levy, Michael, additional, Auger, Gabriel, additional, Kernéis, Solen, additional, Cattoir, Vincent, additional, Alviset, Sophie, additional, Armand-Lefèvre, Laurence, additional, Baldeyrou, Marion, additional, Becker, Agathe, additional, Boibieux, André, additional, Bonacorsi, Stéphane, additional, Burucoa, Christophe, additional, Cambau, Emmanuelle, additional, Casalegno, Jean-Sébastien, additional, Cointe, Aurélie, additional, Cremniter, Julie, additional, Destras, Grégory, additional, Duquaire, Paul, additional, Geslain, Guillaume, additional, Gustave, Claude-Alexandre, additional, Jacquier, Hervé, additional, Kouatchet, Achille, additional, Lecorche, Emmanuel, additional, Lejeune, Manon, additional, Lina, Bruno, additional, Mahieu, Rafaël, additional, Maamar, Adel, additional, Michaud, Anthony, additional, Monnard, Céline, additional, Montravers, Philippe, additional, Neuwirth, Catherine, additional, Péan de Ponfilly, Gauthier, additional, Pichon, Maxime, additional, Plouzeau, Chloé, additional, Poyart, Claire, additional, Quenot, Jean-Pierre, additional, Rzepecki, Vincent, additional, Stéphan, Robin, additional, Timsit, Jean-François, additional, Tran-Dinh, Alexy, additional, Vandenesch, François, additional, and Vigier, Emmanuelle, additional

Published
2021
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40. Neutrophil function and bactericidal activity against Staphylococcus aureus after cardiac surgery with cardiopulmonary bypass

Author

Lesouhaitier, Mathieu, primary, Gregoire, Murielle, additional, Gacouin, Arnaud, additional, Coirier, Valentin, additional, Frerou, Aurélien, additional, Piau, Caroline, additional, Cattoir, Vincent, additional, Dumontet, Erwan, additional, Revest, Matthieu, additional, Tattevin, Pierre, additional, Roisne, Antoine, additional, Verhoye, Jean-Philippe, additional, Flecher, Erwan, additional, Le Tulzo, Yves, additional, Tarte, Karin, additional, and Tadié, Jean-Marc, additional

Published
2021
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41. Bordetella petrii infection with long-lasting persistence in human

Author

Le Coustumier, Alain, Njamkepo, Elisabeth, Cattoir, Vincent, Guillot, Sophie, and Guiso, Nicole

Subjects
Bordetella bronchiseptica -- Research -- Health aspects -- Case studies, Bordetella pertussis -- Health aspects -- Research -- Case studies, Bronchiectasis -- Research -- Causes of -- Case studies -- Health aspects, Health
Abstract

The genus Bordetella comprises 9 species; all, except B. petrii, are obligatorily associated with host organisms (1). The first isolations of B. ansorpii were from a cyst (2) and from [...]

Published
2011

42. Association Between Antibiotic Use and Outcome Among Metastatic Melanoma Patients Receiving Immunotherapy.

Author

Poizeau, Florence, Kerbrat, Sandrine, Balusson, Frédéric, Tattevin, Pierre, Revest, Matthieu, Cattoir, Vincent, Luque-Paz, David, Lesimple, Thierry, Pracht, Marc, Dinulescu, Monica, Russo, David, Oger, Emmanuel, and Dupuy, Alain

Abstract

Background Several observational studies have reported a decreased response to immune checkpoint inhibitors (ICI) following antibiotic use. ICI activity has been hypothesized to be impaired by antibiotic-induced gut dysbiosis. Methods Patients with advanced melanoma receiving an anti-PD-1 antibody as a first-line therapy between 2015 and 2017 in France were selected using the French Health Insurance database. We compared overall survival and time-to-treatment discontinuation according to antibiotic exposure in the 3 months prior to the initiation of anti-PD-1 antibody. To disentangle a causal effect of antibiotics from a confounding bias, we balanced characteristics of patients exposed and nonexposed to antibiotics using an overlap weighting method based on a propensity score. We also evaluated a control cohort of patients with advanced melanoma receiving first-line targeted therapy, as there is no rationale for decreased efficacy of targeted therapy following antibiotic treatment. Results The anti-PD-1 antibody cohort comprised 2605 individuals. Antibiotic exposure in the 3 months prior to anti-PD-1 antibody initiation was not associated with shorter overall survival (weighted hazard ratio = 1.01, 95% confidence interval = 0.88 to 1.17) or time-to-treatment discontinuation (weighted hazard ratio = 1.00, 95% confidence interval = 0.89 to 1.11). Consistent results were observed when the time frame of antibiotics was narrowed to 1 month prior to anti-PD-1 initiation or when exposure was restricted to antibiotics leading to more profound gut dysbiosis. Similar results were observed in the targeted therapy cohort. Conclusions In a large cohort of advanced melanoma patients, we showed that antibiotic use preceding anti-PD-1 antibody was not associated with worse outcome. Physicians should not delay immunotherapy for patients who have recently received antibiotics. [ABSTRACT FROM AUTHOR]

Published
2022
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43. Neutrophil function and bactericidal activity against Staphylococcus aureus after cardiac surgery with cardiopulmonary bypass.

Author

Lesouhaitier, Mathieu, Gregoire, Murielle, Gacouin, Arnaud, Coirier, Valentin, Frerou, Aurélien, Piau, Caroline, Cattoir, Vincent, Dumontet, Erwan, Revest, Matthieu, Tattevin, Pierre, Roisne, Antoine, Verhoye, Jean‐Philippe, Flecher, Erwan, Le Tulzo, Yves, Tarte, Karin, and Tadié, Jean‐Marc

Subjects
CARDIOPULMONARY bypass, CARDIAC surgery, STAPHYLOCOCCUS aureus, NEUTROPHILS, BONE marrow, STAPHYLOCOCCAL diseases
Abstract

Staphylococcus aureus is the main bacterial pathogen encountered in mediastinitis after cardiac surgical procedures; it remains a devastating complication with a high mortality rate. As neutrophils have a primordial role in the defense against staphylococcus infection and cardiopulmonary bypass (CPB) is known to induce immunosuppression, the aim of this study was to investigate CPB impact on neutrophil functions. Patients without known immunosuppression scheduled for cardiac surgery with CPB were included. Bone marrow and blood samples were harvested before, during, and after surgery. Neutrophil phenotypic maturation and functions (migration, adhesion, neutrophil extracellular trap [NET] release, reactive oxygen species (ROS) production, phagocytosis, and bacteria killing) were investigated. Two types of Staphylococcus aureus strains (one from asymptomatic nasal carriage and another from mediastinitis infected tissues) were used to assess in vitro bacterial direct impact on neutrophils. We found that CPB induced a systemic inflammation with an increase in circulating mature neutrophils after surgery. Bone marrow sample analysis did not reveal any modification of neutrophil maturation during CPB. Neutrophil lifespan was significantly increased and functions such as NET release and ROS production were enhanced after CPB whereas bacteria killing and phagocytosis were not impacted. Results were similar with the two different isolates of Staphylococcus aureus. These data suggest that CPB induces a recruitment of mature neutrophils via a demargination process rather than impacting their maturation in the bone marrow. In addition, neutrophils are fully efficient after CPB and do not contribute to postoperative immunosuppression. [ABSTRACT FROM AUTHOR]

Published
2022
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44. Unexpected occurrence of plasmid-mediated quinolone resistance determinants in environmental Aeromonas spp

Author

Cattoir, Vincent, Poirel, Laurent, Aubert, Camille, Soussy, Claude-James, and Nordmann, Patrice

Subjects
Company distribution practices, Enterobacter -- Identification and classification, Enterobacter -- Genetic aspects, Enterobacter -- Distribution, Enterobacter -- Research, Enterobacteriaceae -- Identification and classification, Enterobacteriaceae -- Genetic aspects, Enterobacteriaceae -- Distribution, Enterobacteriaceae -- Research, Quinolones -- Usage, Quinolones -- Research
Abstract

We searched for plasmid-mediated quinolone resistance determinants of the Qnr type in several water samples collected at diverse locations from the Seine River (Paris, France). The qnrS2 genes were identified [...]

Published
2008

45. Additional file 1 of Multicenter evaluation of a syndromic rapid multiplex PCR test for early adaptation of antimicrobial therapy in adult patients with pneumonia

Author

Monard, Céline, Pehlivan, Jonathan, Auger, Gabriel, Alviset, Sophie, Dinh, Alexy Tran, Duquaire, Paul, Gastli, Nabil, D’Humières, Camille, Maamar, Adel, Boibieux, André, Baldeyrou, Marion, Loubinoux, Julien, Dauwalder, Olivier, Cattoir, Vincent, Armand-Lefèvre, Laurence, and Kernéis, Solen

Abstract

Additional file 1: Supplementary table 1. Microbiological documentation depending on the sample type (n=159). Supplementary table 2. Impact of the rm-PCR results on antibiotic prescription, according to the multidisciplinary committee and regarding sample type (n=159). Supplementary Table 3. Description of inadequate antibiotic regimen.

Published
2020
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46. Study of 109 Achromobacter spp. isolates from 9 French CF centres reveals the circulation of a multiresistant clone of A. xylosoxidans belonging to ST 137

Author

Caillon, Jocelyne, Cardot-Martin, Emilie, Cattoir, Vincent, Doléans-Jordheim, Anne, Ferroni, Agnès, Guet-Revillet, Hélène, Héry-Arnaud, Geneviève, Segonds, Christine, Thomas, Elise, Plésiat, Patrick, Vu-Thien, Hoang, Amoureux, Lucie, Sauge, Juliette, Sarret, Benoit, Lhoumeau, Matthieu, Bajard, Audrey, Tetu, Jennifer, Bador, Julien, and Neuwirth, Catherine

Published
2019
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50. Unexpected Cell Wall Alteration-Mediated Bactericidal Activity of the Antifungal Caspofungin against Vancomycin-Resistant Enterococcus faecium

Author

Isnard, Christophe, primary, Hernandez, Sara B., additional, Guérin, François, additional, Joalland, Fanny, additional, Goux, Didier, additional, Gravey, François, additional, Auzou, Michel, additional, Enot, David, additional, Meignen, Pierrick, additional, Giard, Jean-Christophe, additional, Cava, Felipe, additional, and Cattoir, Vincent, additional

Published
2020
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