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Your search keyword '"Chan, Jason Ying-Kuen"' showing total 12 results
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12 results on '"Chan, Jason Ying-Kuen"'

1. Synthetic BZLF1-targeted transcriptional activator for efficient lytic induction therapy against EBV-associated epithelial cancers

Author

Wu, Man, Hau, Pok Man, Li, Linxian, Tsang, Chi Man, Yang, Yike, Taghbalout, Aziz, Chung, Grace Tin-Yun, Hui, Shin Yee, Tang, Wing Chung, Jillette, Nathaniel, Zhu, Jacqueline Jufen, Lee, Horace Hok Yeung, Kong, Ee Ling, Chan, Melissa Sue Ann, Chan, Jason Ying Kuen, Ma, Brigette Buig Yue, Chen, Mei-Ru, Lee, Charles, To, Ka Fai, Cheng, Albert Wu, and Lo, Kwok-Wai

Published
2024
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3. MAPK pathway mutations in head and neck cancer affect immune microenvironments and ErbB3 signaling.

Author

Ngan, Hoi-Lam, Liu, Yuchen, Fong, Andrew Yuon, Poon, Peony Hiu Yan, Yeung, Chun Kit, Chan, Sharon Suet Man, Lau, Alexandria, Piao, Wenying, Li, Hui, Tse, Jessie Sze Wing, Lo, Kwok-Wai, Chan, Sze Man, Su, Yu-Xiong, Chan, Jason Ying Kuen, Lau, Chin Wang, Mills, Gordon B, Grandis, Jennifer Rubin, and Lui, Vivian Wai Yan

Abstract

MAPK pathway mutations affect one-fifth of head and neck squamous cell carcinoma (HNSCC). Unexpectedly, MAPK pathway aberrations are associated with remarkably long patient survival, even among patients with TP53 mutations (median ∼14 yr). We explored underlying outcome-favoring mechanisms with omics followed by preclinical models. Strikingly, multiple hotspot and non-hotspot MAPK mutations (A/BRAF, HRAS, MAPK1, and MAP2K1/2) all abrogated ErbB3 activation, a well-established HNSCC progression signal. Inhibitor studies functionally defined ERK activity negatively regulating phospho-ErbB3 in MAPK-mutants. Furthermore, pan-pathway immunoprofiling investigations identified MAPK-mutant tumors as the only "CD8+ T-cell-inflamed" tumors inherently bearing high-immunoreactive, constitutive cytolytic tumor microenvironments. Immunocompetent MAPK-mutant HNSCC models displayed active cell death and massive CD8+ T-cell recruitment in situ. Consistent with CD8+ T-inflamed phenotypes, MAPK-mutant HNSCC patients, independent of tumor-mutational burden, survived 3.3-4 times longer than WT patients with anti-PD1/PD-L1 immunotherapies. Similar prognosticity was noted in pan-cancers. We uncovered clinical, signaling, and immunological uniqueness of MAPK-mutant HNSCC with potential biomarker utilities predicting favorable patient survival.

Published
2020

8. Epipolar Geometry‐Based Visual Servoing of Soft Endoscopic Manipulator for Transoral Laser Ablation

Author

Fang, Ge, primary, Wang, Xiaomei, additional, Ho, Justin D. L., additional, Wang, Kui, additional, Chow, Chun-Kit, additional, Lee, Kit-Hang, additional, Xie, Xiaochen, additional, Tang, Wai Lun, additional, Liang, Liyuan, additional, Chang, Hing-Chiu, additional, Juan, Chun-Jung, additional, Liu, Yun-hui, additional, Chan, Jason Ying-Kuen, additional, and Kwok, Ka-Wai, additional

Published
2022
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