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Your search keyword '"Chaudhry, Mohammed S."' showing total 10 results
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10 results on '"Chaudhry, Mohammed S."'

2. MAGIC biomarkers predict long-term outcomes for steroid-resistant acute GVHD

Author

Major-Monfried, Hannah, Renteria, Anne S., Pawarode, Attaphol, Reddy, Pavan, Ayuk, Francis, Holler, Ernst, Efebera, Yvonne A., Hogan, William J., Wölfl, Matthias, Qayed, Muna, Hexner, Elizabeth O., Wudhikarn, Kitsada, Ordemann, Rainer, Young, Rachel, Shah, Jay, Hartwell, Matthew J., Chaudhry, Mohammed S., Aziz, Mina, Etra, Aaron, Yanik, Gregory A., Kröger, Nicolaus, Weber, Daniela, Chen, Yi-Bin, Nakamura, Ryotaro, Rösler, Wolf, Kitko, Carrie L., Harris, Andrew C., Pulsipher, Michael, Reshef, Ran, Kowalyk, Steven, Morales, George, Torres, Ivan, Özbek, Umut, Ferrara, James L.M., and Levine, John E.

Published
2018
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6. Survival signal REG3α prevents crypt apoptosis to control acute gastrointestinal graft-versus-host disease

Author

Zhao, Dongchang, primary, Kim, Yeung-Hyen, additional, Jeong, Seihwan, additional, Greenson, Joel K., additional, Chaudhry, Mohammed S., additional, Hoepting, Matthias, additional, Anderson, Erik R., additional, van den Brink, Marcel R.M., additional, Peled, Jonathan U., additional, Gomes, Antonio L.C., additional, Slingerland, Ann E., additional, Donovan, Michael J., additional, Harris, Andrew C., additional, Levine, John E., additional, Ozbek, Umut, additional, Hooper, Lora V., additional, Stappenbeck, Thaddeus S., additional, Ver Heul, Aaron, additional, Liu, Ta-Chiang, additional, Reddy, Pavan, additional, and Ferrara, James L.M., additional

Published
2018
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7. Regenerating Islet-Derived 3-Alpha (REG3A) Protects the Intestinal Stem Cell Niche to Control Acute Gastrointestinal Graft-Versus-Host Disease

Author

Zhao, Dongchang, primary, Kim, Yeung-Hyen, additional, Greenson, Joel K., additional, Chaudhry, Mohammed S., additional, Hoepting, Matthias, additional, Jeong, Seihwan, additional, Anderson, Erik R., additional, Harris, Andrew C., additional, Levine, John E., additional, Ozbek, Umut, additional, Hooper, Lora V., additional, Stappenbeck, Thaddeus S., additional, Heul, Aaron Ver, additional, Liu, Ta-Chiang, additional, Reddy, Pavan, additional, and Ferrara, James, additional

Published
2018
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10. Survival signal REG3α prevents crypt apoptosis to control acute gastrointestinal graft-versus-host disease.

Author

Dongchang Zhao, Yeung-Hyen Kim, Seihwan Jeong, Greenson, Joel K., Chaudhry, Mohammed S., Hoepting, Matthias, Anderson, Erik R., van den Brink, Marcel R. M., Peled, Jonathan U., Gomes, Antonio L. C., Slingerland, Ann E., Donovan, Michael J., Harris, Andrew C., Levine, John E., Özbek, Umut, Hooper, Lora V., Stappenbeck, Thaddeus S., Ver Heul, Aaron M., Ta-Chiang Liu, and Reddy, Pavan

Subjects
*GRAFT versus host disease, *GASTROINTESTINAL system, *EPITHELIAL cells, *STEM cells, *HUMAN microbiota, *CELL lines
Abstract

Graft-versus-host disease (GVHD) in the gastrointestinal (GI) tract remains the major cause of morbidity and nonrelapse mortality after BM transplantation (BMT). The Paneth cell protein regenerating islet-derived 3α (REG3α) is a biomarker specific for GI GVHD. REG3α serum levels rose in the systematic circulation as GVHD progressively destroyed Paneth cells and reduced GI epithelial barrier function. Paradoxically, GVHD suppressed intestinal REG3γ (the mouse homolog of human REG3α), and the absence of REG3γ in BMT recipients intensified GVHD but did not change the composition of the microbiome. IL-22 administration restored REG3γ production and prevented apoptosis of both intestinal stem cells (ISCs) and Paneth cells, but this protection was completely abrogated in Reg3g-/- mice. In vitro, addition of REG3α reduced the apoptosis of colonic cell lines. Strategies that increase intestinal REG3α/γ to promote crypt regeneration may offer a novel, nonimmunosuppressive approach for GVHD and perhaps for other diseases involving the ISC niche, such as inflammatory bowel disease. [ABSTRACT FROM AUTHOR]

Published
2018
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