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2. Glucagon Receptor Modulation: Its Role in Diabetes Care.

Author

Seshadri, Krishna G., Sosale, Aravind R., Kumar, Kanakatte M. Prasanna, Reddy, Sanjay C., and Chawla, Purvi

Subjects
THERAPEUTIC use of monoclonal antibodies, SMALL molecules, GENETIC mutation, GLUCAGON-like peptide 1, DIABETES, CELL receptors, GLUCAGON, NUCLEOTIDES, GLUCAGON-like peptide-1 agonists
Abstract

The metabolic changes attributable to diabetes are due to both deficiency of insulin as well as excess glucagon (GC). The glucagon receptor (GCGR) is a G protein-coupled receptor. GC is predominantly found in the liver. GC exerts its action both at the GCGR and the glucagon-like peptide receptor (GLP1R). Knockout studies as well as human mutation analysis have indicated therapeutic potential as well as concerns of modulation of the GCGR as a potential target for diabetes therapies. Three approaches to GCGR antagonism--small molecules, monoclonal antibodies, and antisense oligonucleotides--have demonstrated an impressive reduction in HbA1C in preclinical and clinical studies. However, adverse events such as an increase in weight cholesterol liver enzymes and alpha cell hyperplasia have stalled further clinical development. On the other hand, balancing the hyperglycemic effect of glucagon and retaining their beneficial effects, especially with weight loss and decrease in weight loss and hepatic steatosis by use of unimolecular coagonists with GLP1 and GIP have shown considerable promise in clinical trials. [ABSTRACT FROM AUTHOR]

Published
2023
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4. 1517-PUB: Prevalence of Self-Reported Central Obesity among Indian Males and Females in a Nationwide Community Screening Program

Author

SABOO, BANSHI D., primary, PARIKH, RAKESH M., additional, GUPTA, AMIT, additional, CH, VASANTH K., additional, MAKKAR, BRIJ M., additional, AGARWAL, SANJAY, additional, CHAWLA, PURVI M., additional, KOVIL, RAJIV R., additional, BHATTACHARYYA, SUPRATIK, additional, CHITTAWAR, SACHIN, additional, and NANDITHA, ARUN, additional

Published
2022
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6. Role of Diabetes Technology for Diabetes Prevention and Improving Public Health Outcomes: A Position Statement by Diabetes Technology Trust of India.

Author

Gupta, Amit, Saboo, Banshi, Kesavadev, Jothydev, Chawla, Manoj, Parikh, Rakesh, Bhartia, Mithun, Joshi, Shashank, Kalra, Sanjay, Unnikrishnan, A. G., Maheshwari, Anuj, Agarwal, Sanjay, Makkar, Brij, Chawla, Purvi, Panda, Jayant, Kaur, Tanvir, Das, Ashok Kumar, and Mohan, Viswanthan

Subjects
EVALUATION of medical care, DIABETES, PUBLIC health, DIGITAL health, METABOLIC disorders, TECHNOLOGY, BEHAVIOR modification
Published
2023
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