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7. Clinical practice consensus for the diagnosis and management of melanoma in Taiwan

Author

Wu, Chiao-En, Liao, Yi-Hua, Wu, Cheng-Lin, Yen, Ruoh-Fang, Lin, Chia-Chi, Yang, Muh-Hwa, Yen, Chueh-Chuan, Su, Wu-Chou, Yen, Chia-Jui, Chang, Yi-Fang, Wu, Ming-Fang, Yang, Youngsen, Lin, Chen-Yuan, Yang, Wen-Chi, Wang, Hui-Ching, Li, Cheng-Yuan, Ho, Yin-Yu, Chang, Yao-Yu, Wu, Chieh-Shan, Hsu, Hsiu-Cheng, Chen, Kuang-Hua, Huang, Yenlin, Chen, Chih-Jung, Chuang, Pei-Ju, Lai, Yung-Chi, Huang, Yu-Yi, Tseng, Neng-Chuan, Huang, Yi-Ting, Chu, Chia-Yu, and Wen-Cheng Chang, John

Published
2024
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16. A hospital cluster of COVID-19 associated with a SARS-CoV-2 superspreading event

Author

Huang, Li-Yueh, Chiu, Yueh-Pi, Hou, Kuei-Chu, Chen, Mei-Lien, Huang, Yu-Chuan, Tsai, Li-Mei, Su, Yu-Hua, Wu, Hsiu-Ping, Liu, Shu-Ling, Wang, Hsiao-Ni, Chang, Li-Fang, Shen, Shu-Hui, Hung, Yun-Chi, Liu, En-Chi, Chen, Yi-Chuan, Yeh, Chiu-Lan, Chang, Hsiao-Chi, Chen, Yu-Ching, Wu, Ya-Ting, Wang, Ching-Yu, Lu, Yi-Rong, Ge, Mao-Cheng, Yang, Jeng-How, Wu, Yen-Mu, Huang, Po-Yen, Wu, Ting-Shu, Cheng, Chun-Wen, Chen, Chih-Jung, Huang, Chung-Guei, Tsao, Kuo-Chien, Lin, Chun-Sui, Chung, Ting-Ying, Lai, Chi-Chun, Yang, Cheng - Ta, Chen, Yi-Ching, and Chiu, Cheng-Hsun

Published
2022
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22. Spectrum and Incidence of Adverse Reactions Post Immunization in the Taiwanese Population (2014–2019): An Analysis Using the National Vaccine Injury Compensation Program.

Author

Lai, Wan-Chun, Yang, Chin-Hui, Huang, Yhu-Chering, Chiu, Nan-Cheng, and Chen, Chih-Jung

Subjects
VACCINATION complications, TAIWANESE people, SEASONAL influenza, BCG vaccines, VACCINATION status
Abstract

Background: Post-marketing surveillance is crucial for gathering data on vaccine reactogenicity, enhancing public trust in immunization, and promoting vaccine uptake. This study aims to characterize adverse events following immunization (AEFIs) and estimate the incidence rates of adverse reactions (ARs) associated with vaccines included in Taiwan's Expanded Program on Immunization (EPI). This study utilizes data from Taiwan's Vaccine Injury Compensation Program (VICP). Methods: Vaccine injury claims submitted to the VICP between 2014 and 2019 were analyzed. ARs were defined as AEFIs adjudicated as "related" or "indeterminate" by the VICP committee. Data on the annual number of vaccine doses administered were obtained from the Taiwan CDC, which helped calculate the AR incidence rates. Results: A total of 491 AEFI claims were reviewed, with 327 (66.6%) categorized as ARs. The AEFIs were mainly associated with the Bacillus Calmette–Guérin (BCG) vaccine (43.4%) and the seasonal influenza vaccine (22.0%). Most EPI vaccines demonstrated low AR incidence rates, ranging from 1.68 to 13.6 per million doses, with the exception of BCG, which exhibited 162.5 ARs per million doses. Shifting BCG immunization from below 5 months to at least 5 months reduced osteomyelitis incidence significantly, from 41.4 to 7.9 (p = 0.0014), but increased abscess and lymphadenitis cases. Conclusions: EPI vaccines in Taiwan are highly safe, with minimal AR incidences in the general population. The BCG vaccine remains an exception, occasionally causing severe ARs like osteomyelitis. Adjusting the immunization schedule to an older age may mitigate some of these adverse effects. [ABSTRACT FROM AUTHOR]

Published
2024
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23. Evaluation of Vaccine Strategies among Healthcare Workers during COVID-19 Omicron Outbreak in Taiwan.

Author

Lin, Min-Ru, Huang, Chung-Guei, Chiu, Cheng-Hsun, and Chen, Chih-Jung

Subjects
MEDICAL personnel, COVID-19 pandemic, BOOSTER vaccines, COVID-19 vaccines, VACCINE immunogenicity, ADENOVIRUS diseases
Abstract

Background/Objectives: This study aimed to assess the reactogenicity and immunogenicity of various SARS-CoV-2 vaccines and compare their protective effects against COVID-19 among healthcare workers (HCWs) during the Omicron outbreak in Taiwan. Methods: Conducted from March 2021 to July 2023, this prospective observational study included healthy HCWs without prior COVID-19 immunization. Participants chose between adenovirus-vectored (AstraZeneca), mRNA (Moderna, BioNTech-Pfizer), and protein-based (Medigen, Novavax) vaccines. Blood samples were taken at multiple points to measure neutralizing antibody (nAb) titers, and adverse events (AEs) were recorded via questionnaires. Results: Of 710 HCWs, 668 (94.1%) completed three doses, and 290 (40.8%) received a fourth dose during the Omicron outbreak. AEs were more common with AstraZeneca and Moderna vaccines, while Medigen caused fewer AEs. Initial nAb titers were highest with Moderna but waned over time regardless of the vaccine. Booster doses significantly increased nAb titers, with the highest levels observed in Moderna BA1 recipients. The fourth dose significantly reduced COVID-19 incidence, with Moderna BA1 being the most effective. Conclusions: Regular booster doses, especially with mRNA and adjuvant-protein vaccines, effectively enhance nAb levels and reduce infection rates, providing critical protection for frontline HCWs during variant outbreaks. [ABSTRACT FROM AUTHOR]

Published
2024
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24. High color-rendering flat lamps using quantum-dot color conversion films

Author

Lien, Jiun-Yi, Chen, Chih-Jung, Chiang, Ray-Kuang, and Wang, Sue-Lein

Subjects
Physics - Optics
Abstract

Colloidal quantum dots are promising next-generation phosphors to enhance the color rendition of light-emitting devices (LEDs) while minimizing the brightness drop. In order to exploit the beneficial tunability of quantum dots for highly efficient devices, optimization and determination of the performance limit are of crucial importance. In this work, a facile preparation process of red-emission quantum dot films and simulation algorithm for fitting this film with two commercial LED flat lamps to the optimized performance are developed. Based on the algorithm, one lamp improves from cold-white light (8669 K) with poor color rendition ($R_{a}=72$) and luminous efficacy (85 lm/W) to warm-white light (2867 K) with $R_{a}=90.8$ and $R_{9}=74.9$, and the other reaches $R_{a}=93\sim95$. Impressively, the brightness drop is only about $15\sim20\%$. Furthermore, our device shows reliability over 1000 hours with only PET (polyethylene-terephthalate) films as the barrier, indicating that this auxiliary red-emission film can be easily applied to improve the color rendition of most commercial LED flat lamps.

Published
2016
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26. Genetic differences between benign phyllodes tumors and fibroadenomas revealed through targeted next generation sequencing

Author

Ng, Cedric Chuan Young, Md Nasir, Nur Diyana, Loke, Benjamin Nathanael, Tay, Timothy Kwang Yong, Thike, Aye Aye, Rajasegaran, Vikneswari, Liu, Wei, Lee, Jing Yi, Guan, Peiyong, Lim, Abner Herbert, Chang, Kenneth Tou En, Gudi, Mihir Ananta, Madhukumar, Preetha, Tan, Benita Kiat Tee, Tan, Veronique Kiak Mien, Wong, Chow Yin, Yong, Wei Sean, Ho, Gay Hui, Ong, Kong Wee, International Fibroepithelial Consortium, Rahman, Norraha Abd, Begum, S. M. Khodeza Nahar, Cheah, Phaik Leng, Chen, Chih Jung, Fuente, Emmanuel Dela, Han, Aaron, Harada, Oi, Kanomata, Naoki, Lee, Cheok Soon, Lee, Jonathan Yu Han, Kamal, Mohammed, Nishimura, Rieko, Ohi, Yasuyo, Sawyer, Elinor J., Teoh, Kean Hooi, Tsang, Alex Koon Ho, Tsang, Julia Yuen-Shan, Tse, Gary M.K., and Yamaguchi, Rin

Published
2021
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43. Quality of care in the course of subcutaneous versus intravenous trastuzumab administration in patients with breast cancer: an integrated time–motion study with mixed-methods research

Author

Lin, Hsiang-Wen, primary, Lin, Chen-Yuan, additional, Yeh, Tzu-Pei, additional, Lin, Tien-Chao, additional, Yeh, Wan-Chen, additional, Yang, Lin-Chun, additional, Chen, Yu-Chieh, additional, Chiu, Li-Ying, additional, Wu, Chen-Teng, additional, Chen, Chih-Jung, additional, Chen, Yu-Fen, additional, Wang, Hwei-Chung, additional, Wu, Yao-Chung, additional, and Liu, Liang-Chih, additional

Published
2023
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44. Self-Nanoemulsifying Drug Delivery System-Containing the Poorly Absorbed Drug – Valsartan in Post-Bariatric Surgery

Author

Huang,Tzu-Hao, Chen,Chih-Jung, Lin,Hsin-Chia Angela, Chen,Chun-Han, Fang,Jia-You, Huang,Tzu-Hao, Chen,Chih-Jung, Lin,Hsin-Chia Angela, Chen,Chun-Han, and Fang,Jia-You

Abstract

Tzu-Hao Huang,1 Chih-Jung Chen,2– 4 Hsin-Chia Angela Lin,1 Chun-Han Chen,1,* Jia-You Fang5– 7,* 1Division of General Surgery, Department of Surgery, Chang Gung Memorial Hospital, Chiayi, Taiwan; 2Department of Pathology and Laboratory Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; 3School of Medicine, Chung Shan Medical University, Taichung, Taiwan; 4Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan; 5Graduate Institute of Natural Products, Chang Gung University, Kweishan, Taoyuan, Taiwan; 6Research Center for Food and Cosmetic Safety, Research Center for Chinese Herbal Medicine, and Graduate Institute of Health Industry Technology, Chang Gung University of Science and Technology, Kweishan, Taoyuan, Taiwan; 7Department of Anesthesiology, Chang Gung Memorial Hospital, Kweishan, Taoyuan, Taiwan*These authors contributed equally to this workCorrespondence: Chun-Han Chen, Division of General Surgery, Department of Surgery, Chang Gung Memorial Hospital, Chiayi, 6, W. Sec., Jiapu Road, Puzih City, Chiayi County, 61363, Taiwan, Tel +886-5-3621000 ext. 3821, Fax +886-5-3623002, Email chen5746@cgmh.org.tw Jia-You Fang, Graduate Institute of Natural Products, Chang Gung University, 259 Wen-Hwa 1st Road, Kweishan, Taoyuan, 333, Taiwan, Tel +886-3-2118800, Fax +886-3-2118236, Email fajy@mail.cgu.edu.twPurpose: Morbid obesity and its related metabolic syndrome are an important health issue. Recently, sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB) have accounted for the most popular bariatric surgeries. Valsartan (VST) is a common hypertension drug, and nano-carriers can increase its solubility and bioavailability. This study aims to explore the nano-VST formula in bariatric surgery subjects.Methods: High-fat fed animals were used as obese models. Operations were performed according to a standardized protocol. The drug was administrated by gavage, and blood sa

Published
2023

49. Calreticulin Expression Controls Cellular Redox, Stemness, and Radiosensitivity to Function as a Novel Adjuvant for Radiotherapy in Neuroblastoma

Author

Chen, Chih-Jung, primary, Hu, Ya-Chuan, additional, Chien, Yueh, additional, Huang, Wei-Chieh, additional, Wu, Chi-Sheng, additional, Tsai, Chung-Ying, additional, Lin, Yang-Hsiang, additional, Lee, Meng-Shiue, additional, Chien, Chian-Shiu, additional, Yang, Yi-Ping, additional, Lee, Meng-Chou, additional, Tseng, Chung-Chih, additional, and Chi, Hsiang-Cheng, additional

Published
2023
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50. Challenges of the eighth edition of the American Joint Committee on Cancer staging system for pathologists focusing on early stage lung adenocarcinoma

Author

Wang, Yu‐Ting, primary, Chang, Il‐Chi, additional, Chen, Chih‐Yi, additional, Hsia, Jiun‐Yi, additional, Lin, Frank Cheau‐Feng, additional, Chao, Wan‐Ru, additional, Ke, Tuan‐Ying, additional, Chen, Ya‐Ting, additional, Chen, Chih‐Jung, additional, Hsieh, Min‐Shu, additional, and Huang, Shiu‐Feng, additional

Published
2023
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