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10 results on '"Chen, Difei"'

3. The application of transbronchial cryobiopsy in interstitial lung disease: a prospective, multicenter, real-world study

Author

Chen, Xiaobo, primary, Li, Jing, additional, Luo, Fengming, additional, Tao, Feng, additional, Zhang, Xiaoju, additional, Wu, Youru, additional, Xu, Ping, additional, Ke, Mingyao, additional, Long, Fa, additional, Liu, Laiyu, additional, Lv, Liping, additional, Liao, Huai, additional, Gu, Ye, additional, Liu, Zhiguang, additional, Tan, Xiaoming, additional, Guo, Shuliang, additional, Hu, Yi, additional, Yang, Huaping, additional, Zhou, Yong, additional, Zhou, Hongmei, additional, Ye, Yongshun, additional, Chen, Difei, additional, and Li, Shiyue, additional

Published
2021
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6. Systematic bias between blinded independent central review and local assessment: literature review and analyses of 76 phase III randomised controlled trials in 45 688 patients with advanced solid tumour

Author

Zhang, Jianrong, primary, Zhang, Yiyin, additional, Tang, Shiyan, additional, Jiang, Long, additional, He, Qihua, additional, Hamblin, Lindsey Tristine, additional, He, Jiaxi, additional, Xu, Zhiheng, additional, Wu, Jieyu, additional, Chen, Yaoqi, additional, Liang, Hengrui, additional, Chen, Difei, additional, Huang, Yu, additional, Wang, Xinyu, additional, Deng, Kexin, additional, Jiang, Shuhan, additional, Zhou, Jiaqing, additional, Xu, Jiaxuan, additional, Chen, Xuanzuo, additional, Liang, Wenhua, additional, and He, Jianxing, additional

Published
2018
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7. Evaluation bias in objective response rate and disease control rate between blinded independent central review and local assessment: a study-level pooled analysis of phase III randomized control trials in the past seven years

Author

Zhang, Jianrong, primary, Zhang, Yiyin, additional, Tang, Shiyan, additional, Liang, Hengrui, additional, Chen, Difei, additional, Jiang, Long, additional, He, Qihua, additional, Huang, Yu, additional, Wang, Xinyu, additional, Deng, Kexin, additional, Jiang, Shuhan, additional, Zhou, Jiaqing, additional, Xu, Jiaxuan, additional, Chen, Xuanzuo, additional, Liang, Wenhua, additional, and He, Jianxing, additional

Published
2017
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10. The alteration of T790M between 19 del and L858R in NSCLC in the course of EGFR-TKIs therapy: a literature-based pooled analysis.

Author

Liang H, Pan Z, Wang W, Guo C, Chen D, Zhang J, Zhang Y, Tang S, He J, and Liang W

Abstract

Background: Treatment-naive epidermal growth factor receptor (EGFR) T790M mutation is more inclined to coexist with L858R than with 19 del in non-small cell lung cancer (NSCLC) patients. However, EGFR-tyrosine kinase inhibitors (EGFR-TKIs) might alter this status. We sought to compare the prevalence of T790M upon acquired resistance to EGFR-TKIs between 19 del and L858R by assembling all existing data., Methods: Electronic databases were comprehensively searched for eligible studies. The primary endpoint was the odds ratio (OR) of T790M mutation in NSCLC co-existing with L858R mutation and 19 del upon resistance to first-generation EGFR-TKIs. A random effects model was used. Stratified analysis was performed based on study type (retrospective and prospective), race (Asians and Caucasians) and sample type (tissue and plasma)., Results: A total of 25 studies involving 1,770 patients were included. The overall T790M existent rate was 45.25%. Post-resistance T790M was more frequent in 19 del than in L858R mutated patients (53% vs. 36%; OR 1.87; P<0.001). All outcomes of subgroup and overall analyses were similar. In contrast, we re-analyzed the previous meta-analysis, finding that the pooled rate of pretreatment T790M was 14% and 22% in 19 del and L858R respectively (OR 0.59; P<0.001). The increase of T790M rate was 2.79-fold in 19 del and only 0.63-fold in L858R in the course of EGFR-TKIs therapy., Conclusions: Opposite to the situation of de novo T790M, it was observed that T790M was more frequent in exon 19 deletion than in L858R among patients with acquired resistance to EGFR-TKIs. The difference in T790M alteration between 19 del and L858R encourages development of detection or treatment strategies for the specific resistance mechanism., Competing Interests: Conflict of Interest: The authors have no conflicts of interest to declare.

Published
2018
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