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8 results on '"Chofflon M"'

3. Re: Errors in the editorial by Christensen and Giovannoni [HERVs: have we been here before? MSJ 18(12) 1670-1672]

Author

Perron, H., Germi, R., Bernard, C., Garcia-Montojo, M., Deluen, C., Farinelli, L., Faucard, R., Veas, F., Stefas, I., Fabriek, B.O., Van-Horssen, J., Vander-Valk, P., Gerdil, C., Mancuso, R., Saresella, M., Clerici, M., Marcel, S., Creange, A., Cavaretta, R., Caputo, D., Arru, G., Morand, P., Lang, A.B., Sotgiu, S., Ruprecht, K., Rieckmann, P., Villoslada, P., Chofflon, M., Boucraut, J., Pelletier, J., and Hartung, H.P.

Subjects
Life, RAPID - Risk Analysis for Products in Development, Food and Nutrition, ELSS - Earth, Life and Social Sciences, Healthy Living, Nutrition
Published
2013

4. PRISMS-4: Long-term efficacy of interferon-beta-1a in relapsing MS

Author

Francis, G, Hughes, R, King, J, Mitchell, P, Joubert, J, McLeod, J, Parker, G, Pollard, J, Sindic, CJM, Duprez, T, Medaer, R, Broeckx, J, Vanroose, E, Carton, H, Wilms, G, Rice, G, Ebers, G, Lee, DH, Freedman, M, Nelson, R, Rabinovitch, H, Christie, S, Avruch, L, Oger, J, Paty, DW, Li, D, Wikstrom, J, Salonen, OLM, Panelius, M, Eralinna, J, Sonninen, P, Rieckmann, P, Hahn, D, Flachenecker, P, Hartung, HP, Uitdehaag, B, Bertelsmann, FW, Barkhof, F, Hommes, OR, Jongen, PJH, Van Doorn, PA, Tanghe, HLG, Sandberg-Wollheim, M, Larsson, EM, Lonntoft, M, Sallerfors, S, Kappos, L, Lienert, C, Radu, EW, Chofflon, M, Roth, S, Castillo, V, Schwieger, AF, Hughes, RAC, Clews, AM, Bingham, JB, Barnes, D, Clifton, AG, Stoy, N, Bates, D, Coulthard, A, Blumhardt, LD, Evans, SM, Jaspan, T, Palace, J, Newsom-Davis, JM, Byrne, JV, Quaghebeur, G, Li, DKB, Zhao, GJ, Riddehough, A, Rhodes, B, Grp, PRISMSS, and Anal, UBCMSMRI

Subjects
Neurology (clinical)
Published
2001

7. Lymphadénopathies persistantes généralisées chez les homosexuels et les toxicomanes: altérations de l'immunité humorale et cellulaire

Author

Roux-Lombard, Pascale, Aladjem, D., Balavoine, J. F., Chofflon, M., Despont, J. P., Hirschel, Bernard, Jeannet, Michel, Kapanci, Y., Toccanier, M. F., and Wilhelm, J. A.

Subjects
Male, Immunity, Cellular, Opioid-Related Disorders/epidemiology/ immunology, T-Lymphocytes, Antibody Formation, Humans, ddc:576.5, Acquired Immunodeficiency Syndrome/epidemiology/ immunology, Homosexuality, Immunoblastic Lymphadenopathy/epidemiology/ etiology/immunology, Lymph Nodes/immunology, Switzerland
Abstract

In two groups of subjects at risk for acquired immune deficiency syndrome (AIDS), homosexual males and intravenous drug users with persistent generalized lymphadenopathy, humoral and cell-mediated immunity were compared. A small group of patients with definite AIDS were also studied. It was found that levels of immunoglobulins, serological markers for virus and other infections, cell-mediated immunity and histology of lymph nodes were similar in homosexuals and drug users, whereas the lymphocyte sub-populations differed completely. The number of T4+ lymphocytes was markedly decreased in homosexuals but normal in drug users; the number of T8+ lymphocytes was much higher in drug users than in homosexuals. This discrepancy may explain the extremely low prevalence of AIDS cases observed among Swiss drug users as compared with the high frequency noted among homosexuals.

Published
1986

8. Repetitive pertussis toxin promotes development of regulatory T cells and prevents central nervous system autoimmune disease.

Author

Weber MS, Benkhoucha M, Lehmann-Horn K, Hertzenberg D, Sellner J, Santiago-Raber ML, Chofflon M, Hemmer B, Zamvil SS, and Lalive PH

Subjects
Animals, CD4-Positive T-Lymphocytes cytology, Cell Proliferation, Female, Forkhead Transcription Factors metabolism, Interleukin-10 metabolism, Interleukin-2 Receptor alpha Subunit metabolism, Mice, Mice, Inbred C57BL, Pertussis Toxin metabolism, T-Lymphocytes, Regulatory metabolism, Transforming Growth Factor beta metabolism, Autoimmune Diseases prevention & control, Central Nervous System Diseases prevention & control, Pertussis Toxin chemistry, T-Lymphocytes immunology
Abstract

Bacterial and viral infections have long been implicated in pathogenesis and progression of multiple sclerosis (MS). Incidence and severity of its animal model experimental autoimmune encephalomyelitis (EAE) can be enhanced by concomitant administration of pertussis toxin (PTx), the major virulence factor of Bordetella pertussis. Its adjuvant effect at the time of immunization with myelin antigen is attributed to an unspecific activation and facilitated migration of immune cells across the blood brain barrier into the central nervous system (CNS). In order to evaluate whether recurring exposure to bacterial antigen may have a differential effect on development of CNS autoimmunity, we repetitively administered PTx prior to immunization. Mice weekly injected with PTx were largely protected from subsequent EAE induction which was reflected by a decreased proliferation and pro-inflammatory differentiation of myelin-reactive T cells. Splenocytes isolated from EAE-resistant mice predominantly produced IL-10 upon re-stimulation with PTx, while non-specific immune responses were unchanged. Longitudinal analyses revealed that repetitive exposure of mice to PTx gradually elevated serum levels for TGF-β and IL-10 which was associated with an expansion of peripheral CD4(+)CD25(+)FoxP3(+) regulatory T cells (Treg). Increased frequency of Treg persisted upon immunization and thereafter. Collectively, these data suggest a scenario in which repetitive PTx treatment protects mice from development of CNS autoimmune disease through upregulation of regulatory cytokines and expansion of CD4(+)CD25(+)FoxP3(+) Treg. Besides its therapeutic implication, this finding suggests that encounter of the immune system with microbial products may not only be part of CNS autoimmune disease pathogenesis but also of its regulation.

Published
2010
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