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10. Pediatric RSV Diagnostic Testing Performance:A Systematic Review and Meta-analysis

Author

Onwuchekwa, Chukwuemeka, Atwell, Jessica, Mora Moreo, Laura, Menon, Sonia, Machado, Belen, Siapka, Mariana, Agarwal, Neha, Rubbrecht, Michelle, Aponte-Torres, Zuleika, Rozenbaum, Mark, Curcio, Daniel, Nair, Harish, V Kalina, Warren, Vroling, Hilde, Gessner, Bradford, and Begier, Elizabeth

Subjects
children, diagnosis, sensitivity and specificity, epidemiology, Respiratory Syncytial Virus Infections
Abstract

Background: Adding additional specimen types (e.g., serology or sputum) to nasopharyngeal swab (NPS) RT-PCR increases respiratory syncytial virus (RSV) detection among adults. We assessed if a similar increase occurs in children and quantified under-ascertainment associated with diagnostic testing.Methods: We searched databases for studies involving RSV detection in persons Results: We included 157 studies. Added testing of additional specimens to NP aspirate (NPA), NPS and/or nasal swab (NS) RT-PCR resulted in statistically non-significant increases in RSV detection. Adding paired serology testing increased RSV detection by 10%, NS by 8%, oropharyngeal swabs by 5%, and NPS by 1%. Compared to RT-PCR, direct fluorescence antibody tests, viral culture, and rapid antigen tests were 87%, 76%, and 74% sensitive, respectively (pooled specificities all ≥98%). Pooled sensitivity of multiplex versus singleplex RT-PCR was 96%.Conclusions: RT-PCR was the most sensitive pediatric RSV diagnostic test. Adding multiple specimens did not substantially increase RSV detection, but even small proportional increases could result in meaningful changes in burden estimates. The synergistic effect of adding multiple specimens should be evaluated.

Published
2023
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23. Antimicrobials : a global alliance for optimizing their rational use in intra-abdominal infections (AGORA)

Author

Sartelli, Massimo, Weber, Dieter G., Ruppe, Etienne, Bassetti, Matteo, Wright, Brian J., Ansaloni, Luca, Catena, Fausto, Coccolini, Federico, Abu-Zidan, Fikri M., Coimbra, Raul, Moore, Ernest E., Moore, Frederick A., Maier, Ronald V., De Waele, Jan J., Kirkpatrick, Andrew W., Griffiths, Ewen A., Eckmann, Christian, Brink, Adrian J., Mazuski, John E., May, Addison K., Sawyer, Rob G., Mertz, Dominik, Montravers, Philippe, Kumar, Anand, Roberts, Jason A., Vincent, Jean-Louis, Watkins, Richard R., Lowman, Warren, Spellberg, Brad, Abbott, Iain J., Adesunkanmi, Abdulrashid Kayode, Al-Dahir, Sara, Al-Hasan, Majdi N., Agresta, Ferdinando, Althani, Asma A., Ansari, Shamshul, Ansumana, Rashid, Augustin, Goran, Bala, Miklosh, Balogh, Zsolt J., Baraket, Oussama, Bhangu, Aneel, Beltran, Marcelo A., Bernhard, Michael, Biffl, Walter L., Boermeester, Marja A., Brecher, Stephen M., Cherry-Bukowiec, Jill R., Buyne, Otmar R., Cainzos, Miguel A., Cairns, Kelly A., Camacho-Ortiz, Adrian, Chandy, Sujith J., Jusoh, Asri Che, Chichom-Mefire, Alain, Colijn, Caroline, Corcione, Francesco, Cui, Yunfeng, Curcio, Daniel, Delibegovic, Samir, Demetrashvili, Zaza, De Simone, Belinda, Dhingra, Sameer, Diaz, Jose J., Di Carlo, Isidoro, Dillip, Angel, Di Saverio, Salomone, Doyle, Michael P., Dorj, Gereltuya, Dogjani, Agron, Dupont, Herve, Eachempati, Soumitra R., Enani, Mushira Abdulaziz, Egiev, Valery N., Elmangory, Mutasim M., Ferrada, Paula, Fitchett, Joseph R., Fraga, Gustavo P., Guessennd, Nathalie, Giamarellou, Helen, Ghnnam, Wagih, Gkiokas, George, Goldberg, Staphanie R., Gomes, Carlos Augusto, Gomi, Harumi, Guzman-Blanco, Manuel, Haque, Mainul, Hansen, Sonja, Hecker, Andreas, Heizmann, Wolfgang R., Herzog, Torsten, Hodonou, Adrien Montcho, Hong, Suk-Kyung, Kafka-Ritsch, Reinhold, Kaplan, Lewis J., Kapoor, Garima, Karamarkovic, Aleksandar, Kees, Martin G., Kenig, Jakub, Kiguba, Ronald, Kim, Peter K., Kluger, Yoram, Khokha, Vladimir, Koike, Kaoru, Kok, Kenneth Y. Y., Kong, Victory, Knox, Matthew C., Inaba, Kenji, Isik, Arda, Iskandar, Katia, Ivatury, Rao R., Labbate, Maurizio, Labricciosa, Francesco M., Laterre, Pierre-Francois, Latifi, Rifat, Lee, Jae Gil, Lee, Young Ran, Leone, Marc, Leppäniemi, Ari, Li, Yousheng, Liang, Stephen Y., Loho, Tonny, Maegele, Marc, Malama, Sydney, Marei, Hany E., Martin-Loeches, Ignacio, Marwah, Sanjay, Massele, Amos, McFarlane, Michael, Melo, Renato Bessa, Negoi, Ionut, Nicolau, David P., Nord, Carl Erik, Ofori-Asenso, Richard, Omari, AbdelKarim H., Ordonez, Carlos A., Ouadii, Mouaqit, Pereira Junior, Gerson Alves, Piazza, Diego, Pupelis, Guntars, Rawson, Timothy Miles, Rems, Miran, Rizoli, Sandro, Rocha, Claudio, Sakakhushev, Boris, Sanchez-Garcia, Miguel, Sato, Norio, Lohse, Helmut A. Segovia, Sganga, Gabriele, Siribumrungwong, Boonying, Shelat, Vishal G., Soreide, Kjetil, Soto, Rodolfo, Talving, Peep, Tilsed, Jonathan V., Timsit, Jean-Francois, Trueba, Gabriel, Trung, Ngo Tat, Ulrych, Jan, van Goor, Harry, Vereczkei, Andras, Vohra, Ravinder S., Wani, Imtiaz, Uhl, Waldemar, Xiao, Yonghong, Yuan, Kuo-Ching, Zachariah, Sanoop K., Zahar, Jean-Ralph, Zakrison, Tanya L., Corcione, Antonio, Melotti, Rita M., Viscoli, Claudio, Viale, Perluigi, II kirurgian klinikka, Department of Surgery, and Clinicum

Subjects
CARBAPENEMASE-PRODUCING ENTEROBACTERIACEAE, INTENSIVE-CARE-UNIT, SPECTRUM-BETA-LACTAMASE, VENTILATOR-ASSOCIATED PNEUMONIA, CLINICAL-PRACTICE GUIDELINES, GRAM-NEGATIVE BACTERIA, CLOSTRIDIUM-DIFFICILE INFECTION, BLOOD-STREAM INFECTIONS, 3126 Surgery, anesthesiology, intensive care, radiology, CRITICALLY-ILL PATIENTS, VANCOMYCIN-RESISTANT ENTEROCOCCI
Abstract

Intra-abdominal infections (IAI) are an important cause of morbidity and are frequently associated with poor prognosis, particularly in high-risk patients. The cornerstones in the management of complicated IAIs are timely effective source control with appropriate antimicrobial therapy. Empiric antimicrobial therapy is important in the management of intra-abdominal infections and must be broad enough to cover all likely organisms because inappropriate initial antimicrobial therapy is associated with poor patient outcomes and the development of bacterial resistance. The overuse of antimicrobials is widely accepted as a major driver of some emerging infections (such as C. difficile), the selection of resistant pathogens in individual patients, and for the continued development of antimicrobial resistance globally. The growing emergence of multi-drug resistant organisms and the limited development of new agents available to counteract them have caused an impending crisis with alarming implications, especially with regards to Gram-negative bacteria. An international task force from 79 different countries has joined this project by sharing a document on the rational use of antimicrobials for patients with IAIs. The project has been termed AGORA (Antimicrobials: A Global Alliance for Optimizing their Rational Use in Intra-Abdominal Infections). The authors hope that AGORA, involving many of the world's leading experts, can actively raise awareness in health workers and can improve prescribing behavior in treating IAIs.

Published
2016

24. A Global Declaration on Appropriate Use of Antimicrobial Agents across the Surgical Pathway

Author

Sartelli, Massimo, Kluger, Yoram, Ansaloni, Luca, Carlet, Jean, Brink, Adrian, Hardcastle, Timothy C., Khanna, Ashish, Chicom-Mefire, Alain, Rodriguez-Bano, Jesus, Nathwani, Dilip, Mendelson, Marc, Watkins, Richard R., Pulcini, Celine, Beovic, Bojana, May, Addison K., Itani, Kamal M. F., Mazuski, John E., Fry, Donald E., Coccolini, Federico, Rasa, Kemal, Montravers, Philippe, Eckmann, Christian, Abbo, Lilian M., Abubakar, Salisu, Abu-Zidan, Fikri M., Adesunkanmi, Abdulrashid Kayode, Al-Hasan, Majdi N., Althani, Asma A., Ticas, Jorge Eduardo Alvarenga, Ansari, Shamshul, Ansumana, Rashid, Araujo da Silva, Andre Ricardo, Augustin, Goran, Bala, Miklosh, Balogh, Zsolt J., Baraket, Oussema, Bassett, Matteo, Bellanova, Giovanni, Beltran, Marcelo A., Ben-Ishay, Ofir, Biffl, Walter L., Boermeester, Marja A., Brecher, Stephen M., Bueno, Juan, Cainzos, Miguel A., Cairns, Kelly, Camacho-Ortiz, Adrian, Ceresoli, Marco, Chandy, Sujith J., Cherry-Bukowiec, Jill R., Cirocchi, Roberto, Colak, Elif, Corcione, Antonio, Cornely, Oliver A., Cortese, Francesco, Cui, Yunfeng, Curcio, Daniel, Damaskos, Dimitris, Das, Koray, Delibegovic, Samir, Deme-Trashvili, Zaza, De Simone, Belinda, de Souza, Hamilton Petry, De Waele, Jan, Dhingra, Sameer, Diaz, Jose J., Di Carlo, Isidoro, Di Marzo, Francesco, Di Saverio, Salomone, Dogjani, Agron, Dorj, Gereltuya, Dortet, Laurent, Duane, Therese M., Dupont, Herve, Egiev, Valery N., Eid, Hani O., Elmangory, Mutasim, Marei, Hany El-Sayed, Enani, Mushira Abdulaziz, Escandon-Vargas, Kevin, Faro Junior, Mario P., Ferrada, Paula, Foghetti, Domitilla, Foianini, Esteban, Fraga, Gustavo P., Frattima, Sabrina, Gandhi, Chinmay, Gattuso, Gianni, Giamarellou, Eleni, Ghnnam, Wagih, Gkiokas, George, Girardis, Massimo, Goff, Debbie A., Gomes, Carlos Augusto, Gomi, Harumi, Guerra Gronerth, Rosio Isabel, Guirao, Xavier, Guzman-Blanco, Manuel, Haque, Mainul, Hecker, Andreas, Hell, Markus, Herzog, Torsten, Hicks, Lauri, Kafka-Ritsch, Reinhold, Kao, Lillian S., Kanj, Souha S., Kaplan, Lewis J., Kapoor, Garima, Karamarkovic, Aleksandar, Kashuk, Jeffry, Kenig, Jakub, Khamis, Faryal, Khokha, Vladimir, Kiguba, Ronald, Kirkpatrick, Andrew W., Korner, Hartwig, Koike, Kaoru, Kok, Kenneth Y. Y., Kon, Kateryna, Kong, Victor, Inaba, Kenji, Ioannidis, Orestis, Isik, Arda, Iskandar, Katia, Labbate, Maurizio, Labricciosa, Francesco M., Lagrou, Katrien, Lagunes, Leonel, Latifi, Rifat, Lasithiotakis, Kostas, Laxminarayan, Ramanan, Lee, Jae Gil, Leone, Marc, Leppaniemi, Ari, Li, Yousheng, Liang, Stephen Y., Liau, Kui-Hin, Litvin, Andrey, Loho, Tonny, Lowman, Warren, Machain, Gustavo M., Maier, Ronald V., Manzano-Nunez, Ramiro, Marinis, Athanasios, Marmorale, Cristina, Martin-Loeches, Ignacio, Marwah, Sanjay, Maseda, Emilio, McFarlane, Michael, de Melo, Renato Bessa, Melotti, Maria Rita, Memish, Ziad, Mertz, Dominik, Mesina, Cristian, Menichetti, Francesco, Mishra, Shyam Kumar, Montori, Giulia, Moore, Ernest E., Moore, Frederick A., Naidoo, Noel, Napolitano, Lena, Negoi, Ionut, Nicolau, David P., Nikolopoulos, Ioannis, Nord, Carl Erik, Ofori-Asenso, Richard, Olaoye, Iyiade, Omari, Abdelkarim H., Ordonez, Carlos A., Ouadii, Mouaqit, Ouedraogo, Abdoul-Salam, Pagani, Leonardo, Paiva, Jose Artur, Parreira, Jose Gustavo, Pata, Francesco, Pereira, Jorge, Pereira, Nuno R., Petrosillo, Nicola, Picetti, Edoardo, Pintar, Tadeja, Ponce-de-Leon, Alfredo, Popovski, Zagorka, Poulakou, Garyphallia, Preller, Jacobus, Guerrero, Adrian Puello, Pupelis, Guntars, Quiodettis, Martha, Rawson, Timothy M., Reichert, Martin, Reinhart, Konrad, Rems, Miran, Rello, Jordi, Rizoli, Sandro, Roberts, Jason, Rubio-Perez, Ines, Ruppc, Etienne, Sakakushev, Boris, Sall, Ibrahima, Kafil, Hossein Samadi, Sanders, James, Sato, Norio, Sawyer, Robert G., Scalea, Thomas, Scibe, Rodolfo, Scudeller, Luigia, Segovia Lohse, Helmut, Sganga, Gabriele, Shafiq, Nusrat, Shah, Jay N., Spigaglia, Patrizia, Suroowan, Shanoo, Tsioutis, Constantinos, Sifri, Costi D., Siribumrungwong, Boonying, Sugrue, Michael, Talving, Peep, Tan, Boun Kim, Tarasconi, Antonio, Tascini, Carlo, Tilsed, Jonathan, Timsit, Jean-Francois, Tumbarello, Mario, Ulrych, Jan, Uranues, Selman, Velmahos, George, Vereczkei, Andras G., Viale, Pierluigi, Vila Estape, Jordi, Viscoli, Claudio, Wagenlehner, Florian, Wright, Brian J., Xiao, Yonghong, Yuan, Kuo-Ching, Zachariah, Sanoop K., Zahar, Jean Ralph, Mergulhao, Paulo, Catena, Fausto, Sartelli, Massimo, Kluger, Yoram, Ansaloni, Luca, Carlet, Jean, Brink, Adrian, Hardcastle, Timothy C., Khanna, Ashish, Chicom-Mefire, Alain, Rodriguez-Bano, Jesus, Nathwani, Dilip, Mendelson, Marc, Watkins, Richard R., Pulcini, Celine, Beovic, Bojana, May, Addison K., Itani, Kamal M. F., Mazuski, John E., Fry, Donald E., Coccolini, Federico, Rasa, Kemal, Montravers, Philippe, Eckmann, Christian, Abbo, Lilian M., Abubakar, Salisu, Abu-Zidan, Fikri M., Adesunkanmi, Abdulrashid Kayode, Al-Hasan, Majdi N., Althani, Asma A., Ticas, Jorge Eduardo Alvarenga, Ansari, Shamshul, Ansumana, Rashid, Araujo da Silva, Andre Ricardo, Augustin, Goran, Bala, Miklosh, Balogh, Zsolt J., Baraket, Oussema, Bassett, Matteo, Bellanova, Giovanni, Beltran, Marcelo A., Ben-Ishay, Ofir, Biffl, Walter L., Boermeester, Marja A., Brecher, Stephen M., Bueno, Juan, Cainzos, Miguel A., Cairns, Kelly, Camacho-Ortiz, Adrian, Ceresoli, Marco, Chandy, Sujith J., Cherry-Bukowiec, Jill R., Cirocchi, Roberto, Colak, Elif, Corcione, Antonio, Cornely, Oliver A., Cortese, Francesco, Cui, Yunfeng, Curcio, Daniel, Damaskos, Dimitris, Das, Koray, Delibegovic, Samir, Deme-Trashvili, Zaza, De Simone, Belinda, de Souza, Hamilton Petry, De Waele, Jan, Dhingra, Sameer, Diaz, Jose J., Di Carlo, Isidoro, Di Marzo, Francesco, Di Saverio, Salomone, Dogjani, Agron, Dorj, Gereltuya, Dortet, Laurent, Duane, Therese M., Dupont, Herve, Egiev, Valery N., Eid, Hani O., Elmangory, Mutasim, Marei, Hany El-Sayed, Enani, Mushira Abdulaziz, Escandon-Vargas, Kevin, Faro Junior, Mario P., Ferrada, Paula, Foghetti, Domitilla, Foianini, Esteban, Fraga, Gustavo P., Frattima, Sabrina, Gandhi, Chinmay, Gattuso, Gianni, Giamarellou, Eleni, Ghnnam, Wagih, Gkiokas, George, Girardis, Massimo, Goff, Debbie A., Gomes, Carlos Augusto, Gomi, Harumi, Guerra Gronerth, Rosio Isabel, Guirao, Xavier, Guzman-Blanco, Manuel, Haque, Mainul, Hecker, Andreas, Hell, Markus, Herzog, Torsten, Hicks, Lauri, Kafka-Ritsch, Reinhold, Kao, Lillian S., Kanj, Souha S., Kaplan, Lewis J., Kapoor, Garima, Karamarkovic, Aleksandar, Kashuk, Jeffry, Kenig, Jakub, Khamis, Faryal, Khokha, Vladimir, Kiguba, Ronald, Kirkpatrick, Andrew W., Korner, Hartwig, Koike, Kaoru, Kok, Kenneth Y. Y., Kon, Kateryna, Kong, Victor, Inaba, Kenji, Ioannidis, Orestis, Isik, Arda, Iskandar, Katia, Labbate, Maurizio, Labricciosa, Francesco M., Lagrou, Katrien, Lagunes, Leonel, Latifi, Rifat, Lasithiotakis, Kostas, Laxminarayan, Ramanan, Lee, Jae Gil, Leone, Marc, Leppaniemi, Ari, Li, Yousheng, Liang, Stephen Y., Liau, Kui-Hin, Litvin, Andrey, Loho, Tonny, Lowman, Warren, Machain, Gustavo M., Maier, Ronald V., Manzano-Nunez, Ramiro, Marinis, Athanasios, Marmorale, Cristina, Martin-Loeches, Ignacio, Marwah, Sanjay, Maseda, Emilio, McFarlane, Michael, de Melo, Renato Bessa, Melotti, Maria Rita, Memish, Ziad, Mertz, Dominik, Mesina, Cristian, Menichetti, Francesco, Mishra, Shyam Kumar, Montori, Giulia, Moore, Ernest E., Moore, Frederick A., Naidoo, Noel, Napolitano, Lena, Negoi, Ionut, Nicolau, David P., Nikolopoulos, Ioannis, Nord, Carl Erik, Ofori-Asenso, Richard, Olaoye, Iyiade, Omari, Abdelkarim H., Ordonez, Carlos A., Ouadii, Mouaqit, Ouedraogo, Abdoul-Salam, Pagani, Leonardo, Paiva, Jose Artur, Parreira, Jose Gustavo, Pata, Francesco, Pereira, Jorge, Pereira, Nuno R., Petrosillo, Nicola, Picetti, Edoardo, Pintar, Tadeja, Ponce-de-Leon, Alfredo, Popovski, Zagorka, Poulakou, Garyphallia, Preller, Jacobus, Guerrero, Adrian Puello, Pupelis, Guntars, Quiodettis, Martha, Rawson, Timothy M., Reichert, Martin, Reinhart, Konrad, Rems, Miran, Rello, Jordi, Rizoli, Sandro, Roberts, Jason, Rubio-Perez, Ines, Ruppc, Etienne, Sakakushev, Boris, Sall, Ibrahima, Kafil, Hossein Samadi, Sanders, James, Sato, Norio, Sawyer, Robert G., Scalea, Thomas, Scibe, Rodolfo, Scudeller, Luigia, Segovia Lohse, Helmut, Sganga, Gabriele, Shafiq, Nusrat, Shah, Jay N., Spigaglia, Patrizia, Suroowan, Shanoo, Tsioutis, Constantinos, Sifri, Costi D., Siribumrungwong, Boonying, Sugrue, Michael, Talving, Peep, Tan, Boun Kim, Tarasconi, Antonio, Tascini, Carlo, Tilsed, Jonathan, Timsit, Jean-Francois, Tumbarello, Mario, Ulrych, Jan, Uranues, Selman, Velmahos, George, Vereczkei, Andras G., Viale, Pierluigi, Vila Estape, Jordi, Viscoli, Claudio, Wagenlehner, Florian, Wright, Brian J., Xiao, Yonghong, Yuan, Kuo-Ching, Zachariah, Sanoop K., Zahar, Jean Ralph, Mergulhao, Paulo, and Catena, Fausto

Abstract

This declaration, signed by an interdisciplinary task force of 234 experts from 83 different countries with different backgrounds, highlights the threat posed by antimicrobial resistance and the need for appropriate use of antibiotic agents and antifungal agents in hospitals worldwide especially focusing on surgical infections. As such, it is our intent to raise awareness among healthcare workers and improve antimicrobial prescribing. To facilitate its dissemination, the declaration was translated in different languages.

Published
2017

25. Imported Dengue in Buenos Aires, Argentina

Author

Seijo, Alfredo, Curcio, Daniel, Aviles, Gabriela, Cernigoi, Beatriz, Deodato, Bettina, and Lloveras, Susana

Subjects
Latin America -- Health aspects, Argentina -- Health aspects, Research, Health aspects, Epidemics -- Argentina -- Research, Communicable diseases -- Research -- Health aspects, Dengue fever -- Research -- Health aspects, Dengue -- Research -- Health aspects
Abstract

To the Editor: After more than 70 years without reports of cases, an outbreak of dengue (type 2) occurred in the northwestern region of Argentina from January to May 1998; [...]

Published
2000

28. Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA).

Author

UCL - SSS/IREC/MEDA - Pôle de médecine aiguë, UCL - (SLuc) Service de soins intensifs, Sartelli, Massimo, Weber, Dieter G, Ruppé, Etienne, Bassetti, Matteo, Wright, Brian J, Ansaloni, Luca, Catena, Fausto, Coccolini, Federico, Abu-Zidan, Fikri M, Coimbra, Raul, Moore, Ernest E, Moore, Frederick A, Maier, Ronald V, De Waele, Jan J, Kirkpatrick, Andrew W, Griffiths, Ewen A, Eckmann, Christian, Brink, Adrian J, Mazuski, John E, May, Addison K, Sawyer, Rob G, Mertz, Dominik, Montravers, Philippe, Kumar, Anand, Roberts, Jason A, Vincent, Jean-Louis, Watkins, Richard R, Lowman, Warren, Spellberg, Brad, Abbott, Iain J, Adesunkanmi, Abdulrashid Kayode, Al-Dahir, Sara, Al-Hasan, Majdi N, Agresta, Ferdinando, Althani, Asma A, Ansari, Shamshul, Ansumana, Rashid, Augustin, Goran, Bala, Miklosh, Balogh, Zsolt J, Baraket, Oussama, Bhangu, Aneel, Beltrán, Marcelo A, Bernhard, Michael, Biffl, Walter L, Boermeester, Marja A, Brecher, Stephen M, Cherry-Bukowiec, Jill R, Buyne, Otmar R, Cainzos, Miguel A, Cairns, Kelly A, Camacho-Ortiz, Adrian, Chandy, Sujith J, Che Jusoh, Asri, Chichom-Mefire, Alain, Colijn, Caroline, Corcione, Francesco, Cui, Yunfeng, Curcio, Daniel, Delibegovic, Samir, Demetrashvili, Zaza, De Simone, Belinda, Dhingra, Sameer, Diaz, José J, Di Carlo, Isidoro, Dillip, Angel, Di Saverio, Salomone, Doyle, Michael P, Dorj, Gereltuya, Dogjani, Agron, Dupont, Hervé, Eachempati, Soumitra R, Enani, Mushira Abdulaziz, Egiev, Valery N, Elmangory, Mutasim M, Ferrada, Paula, Fitchett, Joseph R, Fraga, Gustavo P, Guessennd, Nathalie, Giamarellou, Helen, Ghnnam, Wagih, Gkiokas, George, Goldberg, Staphanie R, Gomes, Carlos Augusto, Gomi, Harumi, Guzmán-Blanco, Manuel, Haque, Mainul, Hansen, Sonja, Hecker, Andreas, Heizmann, Wolfgang R, Herzog, Torsten, Hodonou, Adrien Montcho, Hong, Suk-Kyung, Kafka-Ritsch, Reinhold, Kaplan, Lewis J, Kapoor, Garima, Karamarkovic, Aleksandar, Kees, Martin G, Kenig, Jakub, Kiguba, Ronald, Kim, Peter K, Kluger, Yoram, Khokha, Vladimir, Koike, Kaoru, Kok, Kenneth Y Y, Kong, Victory, Knox, Matthew C, Inaba, Kenji, Isik, Arda, Iskandar, Katia, Ivatury, Rao R, Labbate, Maurizio, Labricciosa, Francesco M, Laterre, Pierre-François, Latifi, Rifat, Lee, Jae Gil, Lee, Young Ran, Leone, Marc, Leppaniemi, Ari, Li, Yousheng, Liang, Stephen Y, Loho, Tonny, Maegele, Marc, Malama, Sydney, Marei, Hany E, Martin-Loeches, Ignacio, Marwah, Sanjay, Massele, Amos, McFarlane, Michael, Melo, Renato Bessa, Negoi, Ionut, Nicolau, David P, Nord, Carl Erik, Ofori-Asenso, Richard, Omari, AbdelKarim H, Ordonez, Carlos A, Ouadii, Mouaqit, Pereira Júnior, Gerson Alves, Piazza, Diego, Pupelis, Guntars, Rawson, Timothy Miles, Rems, Miran, Rizoli, Sandro, Rocha, Claudio, Sakakhushev, Boris, Sanchez-Garcia, Miguel, Sato, Norio, Segovia Lohse, Helmut A, Sganga, Gabriele, Siribumrungwong, Boonying, Shelat, Vishal G, Soreide, Kjetil, Soto, Rodolfo, Talving, Peep, Tilsed, Jonathan V, Timsit, Jean-Francois, Trueba, Gabriel, Trung, Ngo Tat, Ulrych, Jan, van Goor, Harry, Vereczkei, Andras, Vohra, Ravinder S, Wani, Imtiaz, Uhl, Waldemar, Xiao, Yonghong, Yuan, Kuo-Ching, Zachariah, Sanoop K, Zahar, Jean-Ralph, Zakrison, Tanya L, Corcione, Antonio, Melotti, Rita M, Viscoli, Claudio, Viale, Perluigi, UCL - SSS/IREC/MEDA - Pôle de médecine aiguë, UCL - (SLuc) Service de soins intensifs, Sartelli, Massimo, Weber, Dieter G, Ruppé, Etienne, Bassetti, Matteo, Wright, Brian J, Ansaloni, Luca, Catena, Fausto, Coccolini, Federico, Abu-Zidan, Fikri M, Coimbra, Raul, Moore, Ernest E, Moore, Frederick A, Maier, Ronald V, De Waele, Jan J, Kirkpatrick, Andrew W, Griffiths, Ewen A, Eckmann, Christian, Brink, Adrian J, Mazuski, John E, May, Addison K, Sawyer, Rob G, Mertz, Dominik, Montravers, Philippe, Kumar, Anand, Roberts, Jason A, Vincent, Jean-Louis, Watkins, Richard R, Lowman, Warren, Spellberg, Brad, Abbott, Iain J, Adesunkanmi, Abdulrashid Kayode, Al-Dahir, Sara, Al-Hasan, Majdi N, Agresta, Ferdinando, Althani, Asma A, Ansari, Shamshul, Ansumana, Rashid, Augustin, Goran, Bala, Miklosh, Balogh, Zsolt J, Baraket, Oussama, Bhangu, Aneel, Beltrán, Marcelo A, Bernhard, Michael, Biffl, Walter L, Boermeester, Marja A, Brecher, Stephen M, Cherry-Bukowiec, Jill R, Buyne, Otmar R, Cainzos, Miguel A, Cairns, Kelly A, Camacho-Ortiz, Adrian, Chandy, Sujith J, Che Jusoh, Asri, Chichom-Mefire, Alain, Colijn, Caroline, Corcione, Francesco, Cui, Yunfeng, Curcio, Daniel, Delibegovic, Samir, Demetrashvili, Zaza, De Simone, Belinda, Dhingra, Sameer, Diaz, José J, Di Carlo, Isidoro, Dillip, Angel, Di Saverio, Salomone, Doyle, Michael P, Dorj, Gereltuya, Dogjani, Agron, Dupont, Hervé, Eachempati, Soumitra R, Enani, Mushira Abdulaziz, Egiev, Valery N, Elmangory, Mutasim M, Ferrada, Paula, Fitchett, Joseph R, Fraga, Gustavo P, Guessennd, Nathalie, Giamarellou, Helen, Ghnnam, Wagih, Gkiokas, George, Goldberg, Staphanie R, Gomes, Carlos Augusto, Gomi, Harumi, Guzmán-Blanco, Manuel, Haque, Mainul, Hansen, Sonja, Hecker, Andreas, Heizmann, Wolfgang R, Herzog, Torsten, Hodonou, Adrien Montcho, Hong, Suk-Kyung, Kafka-Ritsch, Reinhold, Kaplan, Lewis J, Kapoor, Garima, Karamarkovic, Aleksandar, Kees, Martin G, Kenig, Jakub, Kiguba, Ronald, Kim, Peter K, Kluger, Yoram, Khokha, Vladimir, Koike, Kaoru, Kok, Kenneth Y Y, Kong, Victory, Knox, Matthew C, Inaba, Kenji, Isik, Arda, Iskandar, Katia, Ivatury, Rao R, Labbate, Maurizio, Labricciosa, Francesco M, Laterre, Pierre-François, Latifi, Rifat, Lee, Jae Gil, Lee, Young Ran, Leone, Marc, Leppaniemi, Ari, Li, Yousheng, Liang, Stephen Y, Loho, Tonny, Maegele, Marc, Malama, Sydney, Marei, Hany E, Martin-Loeches, Ignacio, Marwah, Sanjay, Massele, Amos, McFarlane, Michael, Melo, Renato Bessa, Negoi, Ionut, Nicolau, David P, Nord, Carl Erik, Ofori-Asenso, Richard, Omari, AbdelKarim H, Ordonez, Carlos A, Ouadii, Mouaqit, Pereira Júnior, Gerson Alves, Piazza, Diego, Pupelis, Guntars, Rawson, Timothy Miles, Rems, Miran, Rizoli, Sandro, Rocha, Claudio, Sakakhushev, Boris, Sanchez-Garcia, Miguel, Sato, Norio, Segovia Lohse, Helmut A, Sganga, Gabriele, Siribumrungwong, Boonying, Shelat, Vishal G, Soreide, Kjetil, Soto, Rodolfo, Talving, Peep, Tilsed, Jonathan V, Timsit, Jean-Francois, Trueba, Gabriel, Trung, Ngo Tat, Ulrych, Jan, van Goor, Harry, Vereczkei, Andras, Vohra, Ravinder S, Wani, Imtiaz, Uhl, Waldemar, Xiao, Yonghong, Yuan, Kuo-Ching, Zachariah, Sanoop K, Zahar, Jean-Ralph, Zakrison, Tanya L, Corcione, Antonio, Melotti, Rita M, Viscoli, Claudio, and Viale, Perluigi

Abstract

Intra-abdominal infections (IAI) are an important cause of morbidity and are frequently associated with poor prognosis, particularly in high-risk patients. The cornerstones in the management of complicated IAIs are timely effective source control with appropriate antimicrobial therapy. Empiric antimicrobial therapy is important in the management of intra-abdominal infections and must be broad enough to cover all likely organisms because inappropriate initial antimicrobial therapy is associated with poor patient outcomes and the development of bacterial resistance. The overuse of antimicrobials is widely accepted as a major driver of some emerging infections (such as C. difficile), the selection of resistant pathogens in individual patients, and for the continued development of antimicrobial resistance globally. The growing emergence of multi-drug resistant organisms and the limited development of new agents available to counteract them have caused an impending crisis with alarming implications, especially with regards to Gram-negative bacteria. An international task force from 79 different countries has joined this project by sharing a document on the rational use of antimicrobials for patients with IAIs. The project has been termed AGORA (Antimicrobials: A Global Alliance for Optimizing their Rational Use in Intra-Abdominal Infections). The authors hope that AGORA, involving many of the world's leading experts, can actively raise awareness in health workers and can improve prescribing behavior in treating IAIs.

Published
2016

29. Antimicrobials

Author

University of Helsinki, II kirurgian klinikka, Sartelli, Massimo, Weber, Dieter G., Ruppe, Etienne, Bassetti, Matteo, Wright, Brian J., Ansaloni, Luca, Catena, Fausto, Coccolini, Federico, Abu-Zidan, Fikri M., Coimbra, Raul, Moore, Ernest E., Moore, Frederick A., Maier, Ronald V., De Waele, Jan J., Kirkpatrick, Andrew W., Griffiths, Ewen A., Eckmann, Christian, Brink, Adrian J., Mazuski, John E., May, Addison K., Sawyer, Rob G., Mertz, Dominik, Montravers, Philippe, Kumar, Anand, Roberts, Jason A., Vincent, Jean-Louis, Watkins, Richard R., Lowman, Warren, Spellberg, Brad, Abbott, Iain J., Adesunkanmi, Abdulrashid Kayode, Al-Dahir, Sara, Al-Hasan, Majdi N., Agresta, Ferdinando, Althani, Asma A., Ansari, Shamshul, Ansumana, Rashid, Augustin, Goran, Bala, Miklosh, Balogh, Zsolt J., Baraket, Oussama, Bhangu, Aneel, Beltran, Marcelo A., Bernhard, Michael, Biffl, Walter L., Boermeester, Marja A., Brecher, Stephen M., Cherry-Bukowiec, Jill R., Buyne, Otmar R., Cainzos, Miguel A., Cairns, Kelly A., Camacho-Ortiz, Adrian, Chandy, Sujith J., Jusoh, Asri Che, Chichom-Mefire, Alain, Colijn, Caroline, Corcione, Francesco, Cui, Yunfeng, Curcio, Daniel, Delibegovic, Samir, Demetrashvili, Zaza, De Simone, Belinda, Dhingra, Sameer, Diaz, Jose J., Di Carlo, Isidoro, Dillip, Angel, Di Saverio, Salomone, Doyle, Michael P., Dorj, Gereltuya, Dogjani, Agron, Dupont, Herve, Eachempati, Soumitra R., Enani, Mushira Abdulaziz, Egiev, Valery N., Elmangory, Mutasim M., Ferrada, Paula, Fitchett, Joseph R., Fraga, Gustavo P., Guessennd, Nathalie, Giamarellou, Helen, Ghnnam, Wagih, Gkiokas, George, Goldberg, Staphanie R., Gomes, Carlos Augusto, Gomi, Harumi, Guzman-Blanco, Manuel, Haque, Mainul, Hansen, Sonja, Hecker, Andreas, Heizmann, Wolfgang R., Herzog, Torsten, Hodonou, Adrien Montcho, Hong, Suk-Kyung, Kafka-Ritsch, Reinhold, Kaplan, Lewis J., Kapoor, Garima, Karamarkovic, Aleksandar, Kees, Martin G., Kenig, Jakub, Kiguba, Ronald, Kim, Peter K., Kluger, Yoram, Khokha, Vladimir, Koike, Kaoru, Kok, Kenneth Y. Y., Kong, Victory, Knox, Matthew C., Inaba, Kenji, Isik, Arda, Iskandar, Katia, Ivatury, Rao R., Labbate, Maurizio, Labricciosa, Francesco M., Laterre, Pierre-Francois, Latifi, Rifat, Lee, Jae Gil, Lee, Young Ran, Leone, Marc, Leppäniemi, Ari, Li, Yousheng, Liang, Stephen Y., Loho, Tonny, Maegele, Marc, Malama, Sydney, Marei, Hany E., Martin-Loeches, Ignacio, Marwah, Sanjay, Massele, Amos, McFarlane, Michael, Melo, Renato Bessa, Negoi, Ionut, Nicolau, David P., Nord, Carl Erik, Ofori-Asenso, Richard, Omari, AbdelKarim H., Ordonez, Carlos A., Ouadii, Mouaqit, Pereira Junior, Gerson Alves, Piazza, Diego, Pupelis, Guntars, Rawson, Timothy Miles, Rems, Miran, Rizoli, Sandro, Rocha, Claudio, Sakakhushev, Boris, Sanchez-Garcia, Miguel, Sato, Norio, Lohse, Helmut A. Segovia, Sganga, Gabriele, Siribumrungwong, Boonying, Shelat, Vishal G., Soreide, Kjetil, Soto, Rodolfo, Talving, Peep, Tilsed, Jonathan V., Timsit, Jean-Francois, Trueba, Gabriel, Trung, Ngo Tat, Ulrych, Jan, van Goor, Harry, Vereczkei, Andras, Vohra, Ravinder S., Wani, Imtiaz, Uhl, Waldemar, Xiao, Yonghong, Yuan, Kuo-Ching, Zachariah, Sanoop K., Zahar, Jean-Ralph, Zakrison, Tanya L., Corcione, Antonio, Melotti, Rita M., Viscoli, Claudio, Viale, Perluigi, University of Helsinki, II kirurgian klinikka, Sartelli, Massimo, Weber, Dieter G., Ruppe, Etienne, Bassetti, Matteo, Wright, Brian J., Ansaloni, Luca, Catena, Fausto, Coccolini, Federico, Abu-Zidan, Fikri M., Coimbra, Raul, Moore, Ernest E., Moore, Frederick A., Maier, Ronald V., De Waele, Jan J., Kirkpatrick, Andrew W., Griffiths, Ewen A., Eckmann, Christian, Brink, Adrian J., Mazuski, John E., May, Addison K., Sawyer, Rob G., Mertz, Dominik, Montravers, Philippe, Kumar, Anand, Roberts, Jason A., Vincent, Jean-Louis, Watkins, Richard R., Lowman, Warren, Spellberg, Brad, Abbott, Iain J., Adesunkanmi, Abdulrashid Kayode, Al-Dahir, Sara, Al-Hasan, Majdi N., Agresta, Ferdinando, Althani, Asma A., Ansari, Shamshul, Ansumana, Rashid, Augustin, Goran, Bala, Miklosh, Balogh, Zsolt J., Baraket, Oussama, Bhangu, Aneel, Beltran, Marcelo A., Bernhard, Michael, Biffl, Walter L., Boermeester, Marja A., Brecher, Stephen M., Cherry-Bukowiec, Jill R., Buyne, Otmar R., Cainzos, Miguel A., Cairns, Kelly A., Camacho-Ortiz, Adrian, Chandy, Sujith J., Jusoh, Asri Che, Chichom-Mefire, Alain, Colijn, Caroline, Corcione, Francesco, Cui, Yunfeng, Curcio, Daniel, Delibegovic, Samir, Demetrashvili, Zaza, De Simone, Belinda, Dhingra, Sameer, Diaz, Jose J., Di Carlo, Isidoro, Dillip, Angel, Di Saverio, Salomone, Doyle, Michael P., Dorj, Gereltuya, Dogjani, Agron, Dupont, Herve, Eachempati, Soumitra R., Enani, Mushira Abdulaziz, Egiev, Valery N., Elmangory, Mutasim M., Ferrada, Paula, Fitchett, Joseph R., Fraga, Gustavo P., Guessennd, Nathalie, Giamarellou, Helen, Ghnnam, Wagih, Gkiokas, George, Goldberg, Staphanie R., Gomes, Carlos Augusto, Gomi, Harumi, Guzman-Blanco, Manuel, Haque, Mainul, Hansen, Sonja, Hecker, Andreas, Heizmann, Wolfgang R., Herzog, Torsten, Hodonou, Adrien Montcho, Hong, Suk-Kyung, Kafka-Ritsch, Reinhold, Kaplan, Lewis J., Kapoor, Garima, Karamarkovic, Aleksandar, Kees, Martin G., Kenig, Jakub, Kiguba, Ronald, Kim, Peter K., Kluger, Yoram, Khokha, Vladimir, Koike, Kaoru, Kok, Kenneth Y. Y., Kong, Victory, Knox, Matthew C., Inaba, Kenji, Isik, Arda, Iskandar, Katia, Ivatury, Rao R., Labbate, Maurizio, Labricciosa, Francesco M., Laterre, Pierre-Francois, Latifi, Rifat, Lee, Jae Gil, Lee, Young Ran, Leone, Marc, Leppäniemi, Ari, Li, Yousheng, Liang, Stephen Y., Loho, Tonny, Maegele, Marc, Malama, Sydney, Marei, Hany E., Martin-Loeches, Ignacio, Marwah, Sanjay, Massele, Amos, McFarlane, Michael, Melo, Renato Bessa, Negoi, Ionut, Nicolau, David P., Nord, Carl Erik, Ofori-Asenso, Richard, Omari, AbdelKarim H., Ordonez, Carlos A., Ouadii, Mouaqit, Pereira Junior, Gerson Alves, Piazza, Diego, Pupelis, Guntars, Rawson, Timothy Miles, Rems, Miran, Rizoli, Sandro, Rocha, Claudio, Sakakhushev, Boris, Sanchez-Garcia, Miguel, Sato, Norio, Lohse, Helmut A. Segovia, Sganga, Gabriele, Siribumrungwong, Boonying, Shelat, Vishal G., Soreide, Kjetil, Soto, Rodolfo, Talving, Peep, Tilsed, Jonathan V., Timsit, Jean-Francois, Trueba, Gabriel, Trung, Ngo Tat, Ulrych, Jan, van Goor, Harry, Vereczkei, Andras, Vohra, Ravinder S., Wani, Imtiaz, Uhl, Waldemar, Xiao, Yonghong, Yuan, Kuo-Ching, Zachariah, Sanoop K., Zahar, Jean-Ralph, Zakrison, Tanya L., Corcione, Antonio, Melotti, Rita M., Viscoli, Claudio, and Viale, Perluigi

Abstract

Intra-abdominal infections (IAI) are an important cause of morbidity and are frequently associated with poor prognosis, particularly in high-risk patients. The cornerstones in the management of complicated IAIs are timely effective source control with appropriate antimicrobial therapy. Empiric antimicrobial therapy is important in the management of intra-abdominal infections and must be broad enough to cover all likely organisms because inappropriate initial antimicrobial therapy is associated with poor patient outcomes and the development of bacterial resistance. The overuse of antimicrobials is widely accepted as a major driver of some emerging infections (such as C. difficile), the selection of resistant pathogens in individual patients, and for the continued development of antimicrobial resistance globally. The growing emergence of multi-drug resistant organisms and the limited development of new agents available to counteract them have caused an impending crisis with alarming implications, especially with regards to Gram-negative bacteria. An international task force from 79 different countries has joined this project by sharing a document on the rational use of antimicrobials for patients with IAIs. The project has been termed AGORA (Antimicrobials: A Global Alliance for Optimizing their Rational Use in Intra-Abdominal Infections). The authors hope that AGORA, involving many of the world's leading experts, can actively raise awareness in health workers and can improve prescribing behavior in treating IAIs.

Published
2016

30. Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA)

Author

Sartelli, Massimo, primary, Weber, Dieter G., additional, Ruppé, Etienne, additional, Bassetti, Matteo, additional, Wright, Brian J., additional, Ansaloni, Luca, additional, Catena, Fausto, additional, Coccolini, Federico, additional, Abu-Zidan, Fikri M., additional, Coimbra, Raul, additional, Moore, Ernest E., additional, Moore, Frederick A., additional, Maier, Ronald V., additional, De Waele, Jan J., additional, Kirkpatrick, Andrew W., additional, Griffiths, Ewen A., additional, Eckmann, Christian, additional, Brink, Adrian J., additional, Mazuski, John E., additional, May, Addison K., additional, Sawyer, Rob G., additional, Mertz, Dominik, additional, Montravers, Philippe, additional, Kumar, Anand, additional, Roberts, Jason A., additional, Vincent, Jean-Louis, additional, Watkins, Richard R., additional, Lowman, Warren, additional, Spellberg, Brad, additional, Abbott, Iain J., additional, Adesunkanmi, Abdulrashid Kayode, additional, Al-Dahir, Sara, additional, Al-Hasan, Majdi N., additional, Agresta, Ferdinando, additional, Althani, Asma A., additional, Ansari, Shamshul, additional, Ansumana, Rashid, additional, Augustin, Goran, additional, Bala, Miklosh, additional, Balogh, Zsolt J., additional, Baraket, Oussama, additional, Bhangu, Aneel, additional, Beltrán, Marcelo A., additional, Bernhard, Michael, additional, Biffl, Walter L., additional, Boermeester, Marja A., additional, Brecher, Stephen M., additional, Cherry-Bukowiec, Jill R., additional, Buyne, Otmar R., additional, Cainzos, Miguel A., additional, Cairns, Kelly A., additional, Camacho-Ortiz, Adrian, additional, Chandy, Sujith J., additional, Che Jusoh, Asri, additional, Chichom-Mefire, Alain, additional, Colijn, Caroline, additional, Corcione, Francesco, additional, Cui, Yunfeng, additional, Curcio, Daniel, additional, Delibegovic, Samir, additional, Demetrashvili, Zaza, additional, De Simone, Belinda, additional, Dhingra, Sameer, additional, Diaz, José J., additional, Di Carlo, Isidoro, additional, Dillip, Angel, additional, Di Saverio, Salomone, additional, Doyle, Michael P., additional, Dorj, Gereltuya, additional, Dogjani, Agron, additional, Dupont, Hervé, additional, Eachempati, Soumitra R., additional, Enani, Mushira Abdulaziz, additional, Egiev, Valery N., additional, Elmangory, Mutasim M., additional, Ferrada, Paula, additional, Fitchett, Joseph R., additional, Fraga, Gustavo P., additional, Guessennd, Nathalie, additional, Giamarellou, Helen, additional, Ghnnam, Wagih, additional, Gkiokas, George, additional, Goldberg, Staphanie R., additional, Gomes, Carlos Augusto, additional, Gomi, Harumi, additional, Guzmán-Blanco, Manuel, additional, Haque, Mainul, additional, Hansen, Sonja, additional, Hecker, Andreas, additional, Heizmann, Wolfgang R., additional, Herzog, Torsten, additional, Hodonou, Adrien Montcho, additional, Hong, Suk-Kyung, additional, Kafka-Ritsch, Reinhold, additional, Kaplan, Lewis J., additional, Kapoor, Garima, additional, Karamarkovic, Aleksandar, additional, Kees, Martin G., additional, Kenig, Jakub, additional, Kiguba, Ronald, additional, Kim, Peter K., additional, Kluger, Yoram, additional, Khokha, Vladimir, additional, Koike, Kaoru, additional, Kok, Kenneth Y. Y., additional, Kong, Victory, additional, Knox, Matthew C., additional, Inaba, Kenji, additional, Isik, Arda, additional, Iskandar, Katia, additional, Ivatury, Rao R., additional, Labbate, Maurizio, additional, Labricciosa, Francesco M., additional, Laterre, Pierre-François, additional, Latifi, Rifat, additional, Lee, Jae Gil, additional, Lee, Young Ran, additional, Leone, Marc, additional, Leppaniemi, Ari, additional, Li, Yousheng, additional, Liang, Stephen Y., additional, Loho, Tonny, additional, Maegele, Marc, additional, Malama, Sydney, additional, Marei, Hany E., additional, Martin-Loeches, Ignacio, additional, Marwah, Sanjay, additional, Massele, Amos, additional, McFarlane, Michael, additional, Melo, Renato Bessa, additional, Negoi, Ionut, additional, Nicolau, David P., additional, Nord, Carl Erik, additional, Ofori-Asenso, Richard, additional, Omari, AbdelKarim H., additional, Ordonez, Carlos A., additional, Ouadii, Mouaqit, additional, Pereira Júnior, Gerson Alves, additional, Piazza, Diego, additional, Pupelis, Guntars, additional, Rawson, Timothy Miles, additional, Rems, Miran, additional, Rizoli, Sandro, additional, Rocha, Claudio, additional, Sakakhushev, Boris, additional, Sanchez-Garcia, Miguel, additional, Sato, Norio, additional, Segovia Lohse, Helmut A., additional, Sganga, Gabriele, additional, Siribumrungwong, Boonying, additional, Shelat, Vishal G., additional, Soreide, Kjetil, additional, Soto, Rodolfo, additional, Talving, Peep, additional, Tilsed, Jonathan V., additional, Timsit, Jean-Francois, additional, Trueba, Gabriel, additional, Trung, Ngo Tat, additional, Ulrych, Jan, additional, van Goor, Harry, additional, Vereczkei, Andras, additional, Vohra, Ravinder S., additional, Wani, Imtiaz, additional, Uhl, Waldemar, additional, Xiao, Yonghong, additional, Yuan, Kuo-Ching, additional, Zachariah, Sanoop K., additional, Zahar, Jean-Ralph, additional, Zakrison, Tanya L., additional, Corcione, Antonio, additional, Melotti, Rita M., additional, Viscoli, Claudio, additional, and Viale, Perluigi, additional

Published
2016
Full Text
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31. Uso inicial de tigeciclina en Argentina

Author

Curcio, Daniel, Fernández, Francisco, and Duret, Fernando

Subjects
off label indications, neumonía asociada a ventilación mecánica, Tigeciclina, indicaciones no aprobadas, ventilator associated pneumonia, Tigecycline
Abstract

Tigeciclina es una nueva clase de antimicrobiano activo contra patógenos nosocomiales emergentes como Staphylococcus aureus resistente a meticilina, enterobacterias productoras de (3-lactamasas de espectro extendido y Acinetobacter sp multi-resistente. Hasta el momento, ha sido aprobado para el tratamiento de infecciones intra-abdominales complicadas e infecciones de piel y tejido celular subcutáneo complicadas, pero su perfil farmacológico y microbiológico resulta atractivo para prescribirlo en otras patologías, sobre todo aquellas causadas por patógenos resistentes. El objetivo de este estudio fue evaluar en qué indicaciones fue utilizada tigeciclina en Argentina durante el primer mes después de su lanzamiento. Para tal fin, fueron analizadas las prescripciones de tigeciclina en 69 pacientes con infecciones graves en 15 instituciones. Quince pacientes (21%) recibieron tigeciclina para indicaciones aprobadas y 54 (79%) para indicaciones no aprobadas -off label- (56% con respaldo científico y 23% con mínimo o nulo respaldo científico). La indicación más frecuente, dentro de las no aprobadas, fue la neumonía asociada a ventilación mecánica (NAVM) (36 pacientes). Se demostró la etiología de las infecciones en 61% de los pacientes. En todos ellos las bacterias aisladas fueron Acinetobacter sp multi-resistente (MR) incluidos los carbapenemes. Nuestro estudio muestra que la prescripción de tigeciclina para indicaciones no aprobadas es frecuente, especialmente en NAVM. Dentro de las razones que podrían explicar este fenómeno, se encuentra el escaso número de opciones terapéuticas para el tratamiento de infecciones graves por Acinetobacter sp (p. ej: colistín). Sin embargo, es aconsejable que los médicos evalúen el beneficio/riesgo de usar este antimicrobiano para indicaciones que carecen aún de respaldo científico consistente Tigecycline is a new class of antibiotics active against emerging nosocomial pathogens as methicillin-resistant Staphylococcus aureus, extended spectrum (3-lactamases-producing enterobacteria and multidrug-resistant Acinetobacter sp. It was approved for the treatment of complicated intra-abdominal infections and complicated skin and skin structure infections, but its pharmacological and microbiological profile is attractive to physicians for using it in other pathologies caused by resistant pathogens. The aim of this study was to evaluate in which indications tigecycline was used in Argentinian usual clinical settings during the first months after its launch. We analyzed tigecycline prescriptions in 69 patients with severe infections in 15 institutions. Fifteen patients (21%) received tigecycline for approved indications, and 54 (79%) for off label indications (56%) with scientific support and 23%> with limited or without any scientific support). The most frequent off label use was ventilator associated pneumonia (VAP) (36 patients). The etiology of the infections was established in 61%> of the patients. In all cases the isolated bacteria were multi-drug resistant (MDR) Acinetobacter s/?.-carbapenems included. Our study shows that the off label use of tigecycline is frequent, specially in VAP. One of the reasons could be that for MDR-Acinetobacter sp. -VAP, there are few therapeutic options (for instance: colistin). Physicians must evaluate the benefits/risks to use this antibiotic for indications that lack rigorous scientific support

Published
2007

35. Current Rational to Prescribe Tigecycline: Critical Analysis of the Evidence and Usage Algorithms by an Argentinean Experts Panel

Author

Curcio, Daniel, primary, Barcelona, Laura I., additional, Cornistein, Wanda, additional, Bantar, Carlos, additional, Barcan, Laura, additional, Bonvehí, Pablo, additional, Reina, Rosa, additional, Bergallo, Carlos, additional, Biondi, Héctor, additional, Calderón, Jorge, additional, Castagnino, Jorge, additional, Chinchilla, Paulo, additional, Dignani, María Cecilia, additional, Esposto, Amadeo, additional, Pérez, Norma Falcón, additional, Freuler, Cristina, additional, Luna, Carlos M., additional, Ríos, Fernando, additional, Rodriguez, Claudia, additional, valentini, Ricardo, additional, Vazquez, Walter, additional, verbanaz, Sergio, additional, and vergara, Gabriel, additional

Published
2009
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38. Incidence and diagnosis of ventilator-associated tracheobronchitis (VAT) in the intensive care unit: an international online survey.

Author

Rodríguez, Alejandro, Póvoa, Pedro, Nseir, Saad, Salluh, Jorge, Curcio, Daniel, and Martín-Loeches, Ignacio

Subjects
ALLELOPATHIC agents, CRITICAL care medicine, INTERNET surveys, MICROBIAL metabolites, PHYTONCIDES, MORTALITY
Abstract

Introduction Several aspects of ventilator-associated tracheobronchitis (VAT) remain poorly defined, including diagnostic criteria, overlap with ventilator-associated pneumonia (VAP) and appropriate treatment regimens. The objective of this study was to survey reported practices in the clinical and microbiological diagnosis of VAT, and to evaluate perceptions of the impact of VAT on patient outcomes. Methods We developed a questionnaire comprising of: 1) Characteristics of the respondent, the ICU and hospital, 2) current clinical and microbiological diagnostic approach, 3) empirical antibiotic therapy and 4) the perception of physicians regarding the clinical impact of VAT and its implications. Results A total of 288 ICUs from 16 different countries answered the survey, 147 (51%) from the Latin American Group (LA) and 141 (49%) from Spain, Portugal and France (SPF group). The majority of respondents (n = 228; 79.2%) reported making the diagnosis of VAT based on clinical and microbiological criteria and 40 (13.9%) by clinical criteria alone. Approximately half (50.3%) of the respondents agreed that patients should receive antibiotics (ATB) for the treatment of VAT. Out of all respondents, 269 (93.4%) assume that a VAT episode increases ICU length of stay and this perception is greater in LA (97.3%) than in SPF group (89.4%, P <0.05). Half of the physicians considered that VAT increases the risk of mortality, and this perception is again greater in LA (58.5% versus 41.1%, P <0.05). Conclusion Given the possible high incidence of VAT and the perception of its importance as a risk factor for VAP and mortality, a large multicentre international prospective study would be helpful to validate a consensual definition of VAT, to determine its incidence and delineate its impact on subsequent VAP occurrence. [ABSTRACT FROM AUTHOR]

Published
2014
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40. Letters.

Author

Papa, Anna, Mills, James N., Kouidou, Sophie, Ma, Benjiang, Papadimitriou, Evagelia, Antoniadis, Antonis, Seijo, Alfredo, Curcio, Daniel, Aviles, Gabriela, Cernigoi, Beatriz, Deodato, Bettina, Lloveras, Susana, Gern, Lise, Humair, Pierre-Francois, Randolph, Sarah, Richter, Dania, Spielman, Andrew, Komar, Nicholas, and Matuschka, Franz-Rainer

Subjects
COMMUNICABLE diseases, HANTAVIRUSES, DENGUE viruses, LYME disease
Abstract

Presents information on infectious diseases. Preliminary characterization and natural history of Hantaviruses in rodents in Northern Greece; Information on the dengue outbreak in Argentina; Competence of American robins as reservoir hosts for Lyme disease spirochetes.

Published
2000

41. Correspondence.

Author

Curcio, Daniel

Subjects
LETTERS to the editor, METHICILLIN resistance, STAPHYLOCOCCUS aureus
Abstract

A letter to the editor is presented in response to the article "Clinical Practice Guidelines by the Infectious Diseases Society of America for the Treatment of Methicillin-Resistant Staphylococcus aureus Infections in Adults and Children," in the February 1, 2011 issue.

Published
2011
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42. Incidence and diagnosis of ventilator-associated tracheobronchitis in the intensive care unit: an international online survey.

Author

Rodríguez, Alejandro, Póvoa, Pedro, Nseir, Saad, Salluh, Jorge, Curcio, Daniel, Martín-Loeches, Ignacio, and TAVeM group investigators

Abstract

Introduction: Several aspects of ventilator-associated tracheobronchitis (VAT)-including diagnostic criteria, overlap with ventilator-associated pneumonia (VAP), and appropriate treatment regimens-remain poorly defined. The objectives of this study were to survey reported practices in the clinical and microbiological diagnosis of VAT and to evaluate perceptions of the impact of VAT on patient outcomes.Methods: We developed a questionnaire consisting of (a) characteristics of the respondent, the ICU, and hospital; (b) current clinical and microbiological diagnostic approach; (c) empirical antibiotic therapy; and (d) the perception of physicians regarding the clinical impact of VAT and its implications.Results: A total of 288 ICUs from 16 different countries answered the survey: 147 (51%) from the Latin American (LA) group and 141 (49%) from Spain, Portugal, and France (SPF group). The majority of respondents (n = 228; 79.2%) reported making the diagnosis of VAT based on clinical and microbiological criteria, and 40 (13.9%) by clinical criteria alone. Approximately half (50.3%) of the respondents agreed that patients should receive antibiotics for the treatment of VAT. Out of all respondents, 269 (93.4%) assume that a VAT episode increases ICU length of stay, and this perception is greater in the LA group (97.3%) than in the SPF group (89.4%, P <0.05). Half of the physicians considered that VAT increases the risk of mortality, and this perception is again greater in the LA group (58.5% versus 41.1%, P <0.05).Conclusions: Given the possible high incidence of VAT and the perception of its importance as a risk factor for VAP and mortality, a large multicenter international prospective study would be helpful to validate a consensual definition of VAT, determine its incidence, and delineate its impact on subsequent VAP occurrence. [ABSTRACT FROM AUTHOR]

Published
2014
Full Text
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43. A Global Declaration on Appropriate Use of Antimicrobial Agents across the Surgical Pathway

Author

Sartelli, M., Kluger, Y., Ansaloni, L., Carlet, J., Brink, A., Hardcastle, T. C., Khanna, A., Chicom-Mefire, A., Rodríguez-Baño, J., Nathwani, D., Mendelson, M., Watkins, R. R., Pulcini, C., Beović, B., May, A. K., Itani, K. M. F., Mazuski, J. E., Fry, D. E., Coccolini, F., Rasxa, K., Montravers, P., Eckmann, C., Abbo, L. M., Abubakar, S., Abu-Zidan, F. M., Adesunkanmi, A. K., Al-Hasan, M. N., Althani, A. A., Ticas, J. E. A., Ansari, S., Ansumana, R., Da Silva, A. R. A. , Augustin, G. , Bala, M. , Balogh, Z. J. , Baraket, O. , Bassetti, M. , Bellanova, G. , Beltran, M. A. , Ben-Ishay, O. , Boermeester, M. A. , Brecher, S. M. , Bueno, J. , Cainzos, M. A. , Cairns, K. , Camacho-Ortiz, A. , Ceresoli, M. , Chandy, S. J. , Cherry-Bukowiec, J. R. , Cirocchi, R. , Colak, E. , Corcione, A. , Cornely, O. A. , Cortese, F. , Cui, Y. , Curcio, D. , Damaskos, D. , Dasx, K. , Delibegovic, S. , Demetrashvili, Z. be, De Simone, B. bf, De Souza, H. P. bg, De Waele, J. bh, Dhingra, S. bi, Diaz, J. J. bj, Di Carlo, I. bk, Di Marzo, F. bl, DI TOMASO, SAVERIO, S. , Dogjani, A. , Dorj, G. , Dortet, L. , Duane, T. M. , Dupont, H. , Egiev, V. N. , Eid, H. O. , Elmangory, El-Sayed Marei, H. , Enani, M. A. , Escandón-Vargas, K. , Faro, M. P. , J.r., Ferrada, P., Foghetti, D., Foianini, E., Fraga, G. P., Frattima, S., Gandhi, C., Gattuso, G., Giamarellou, E., Ghnnam, W., Gkiokas, G., Girardis, M., Goff, D. A., Gomes, C. A., Gomi, H., Gronerth, R. I. G., Guirao, X., Guzman-Blanco, M., Haque, M., Hecker, A., Hell, M., Herzog, T., Hicks, L., Kafka-Ritsch, R., Kao, L. S., Kanj, S. S., Kaplan, L. J., Kapoor, G., Karamarkovic, A., Kashuk, J., Kenig, J., Khamis, F., Khokha, V., Kiguba, R., Kirkpatrick, A. W., Kørner, H., Koike, K., Kok, K. Y. Y., Kon, K., Kong, V., Inaba, K., Ioannidis, O., Isik, A., Iskandar, K., Labbate, M., Labricciosa, F. M., Lagrou, K., Lagunes, L., Latifi, R., Lasithiotakis, K., Laxminarayan, R., Lee, J. G., Leone, M., Leppäniemi, A., Li, Y., Liang, S. Y., Liau, K. -.H., Litvin, A., Loho, T., Lowman, W., Machain, G. Mf, Maier, R. V., Manzano-Nunez, R., Marinis, A., Marmorale, C., Martin-Loeches, I., Marwah, S., Maseda, E., McFarlane, M., BEZERRA DE MELO PEREIRA NUNES, CINTIA, R. , Melotti, R. , Memish, Z. , Mertz, D. , Mesina, C. , Menichetti, F. , Mishra, S. K. , Montori, G. , Moore, E. E. , Moore, F. A. , Naidoo, NAPOLITANO, NELLO, L. , Negoi, I. , Nicolau, D. P. , Nikolopoulos, I. , Nord, C. E. , Ofori-Asenso, R. , Olaoye, I. , Omari, A. H. , Ordoñez, C. A. , Ouadii, M. , Ouedraogo, A. , Pagani, L. , Paiva, J. A. , Parreira, J. G. , Pata, F. fm, Pereira, J., Pereira, N. R., Petrosillo, N., Picetti, E., Pintar, T., Ponce-De-Leon, A., Popovski, Z., Poulakou, G., Preller, J., Guerrero, A. P., Pupelis, G., Quiodettis, M., Rawson, T. M., Reichert, M., Reinhart, K., Rems, M., Rello, J., Rizoli, S., ROBERTS, HENRI JOHAN EDUARD, Rubio-Perez, I., Ruppé, E., Sakakushev, B., Sall, I., Kafil, H. S. j, Sanders, J., Sato, N., Sawyer, R. G., T. , Scibé, R. , Scudeller, L. , Lohse, H. S. , Sganga, G. , Shafiq, N. , Shah, J. N. , Spigaglia, P. , Suroowan, S. , Tsioutis, C. , Sifri, C. D. , Siribumrungwong, B. , Sugrue, M. , Talving, P. , Tan, B. K. , Tarasconi, A. , Tascini, C. , Tilsed, J. , Timsit, J. -.F. , Tumbarello, M. , Trung, N. T. , Ulrych, J. , Uranues, S. , Velmahos, G. , Vereczkei, A. G. , Viale, P. , Estape, J. V. , Viscoli, C. , Wagenlehner, F. , Wright, B. J. , Xiao, Y. , Yuan, K. -.C. , Zachariah, S. K. , Zahar, J. R. , Mergulhão, P. , Catena, Réanimation Médico-Chirurgicale, Groupe Hospitalier Paris Saint-Joseph, University Hospital Virgen Macarena, Internal Medicine Department, Universidad de Sevilla, Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale (SESSTIM - U912 INSERM - Aix Marseille Univ - IRD), Institut de Recherche pour le Développement (IRD)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Aix Marseille Université (AMU), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), Service d'anesthésie - réanimation chirurgicale, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Klinik I für Innere Medizin und Zentrum für Klinische Studien (ZKS) 01KN0706, Universitätsklinikum Köln (Uniklinik Köln), AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), CHU Amiens-Picardie, Paracelsus Medizinische Privatuniversität = Paracelsus Medical University (PMU), Université Catholique de Louvain = Catholic University of Louvain (UCL), Center for Disease Dynamics, Economics & Policy (CDDEP), Unité de Recherche sur les Maladies Infectieuses Tropicales Emergentes (URMITE), Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes (URMITE), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR48, INSB-INSB-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR48, INSB-INSB-Centre National de la Recherche Scientifique (CNRS), Hartford Hospital, Department of Laboratory Medicine, Karolinska Institutet [Stockholm], Pathogénèse et contrôle des infections chroniques (PCCI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre Hospitalier Universitaire de Montpellier (CHU Montpellier ), Instituto Nacional de Matemática Pura e Aplicada (IMPA), Instituto Nacional de matematica pura e aplicada, 4th Department of Internal Medicine, ATTIKON University General Hospital, Department of Anesthesiology and Intensive Care, Friedrich-Schiller-Universität = Friedrich Schiller University Jena [Jena, Germany], Critical Care Department, Joan XXIII University Hospital, Departmet of Infectious, Parasitic and Immune-Mediated Disease, Istituto Superiore di Sanita [Rome], Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC), Department of Internal Medicine, Geriatrics and Nephrologic Diseases, Section of Infectious Diseases, S.Orsola-Malpighi Hospital, Alma Mater Studiorum University of Bologna (UNIBO), Infectious Diseases, University of Genoa (UNIGE), Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), Groupe Hospitalier Paris Saint-Joseph (hpsj), Universidad de Sevilla / University of Sevilla, Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Nice Sophia Antipolis (1965 - 2019) (UNS), Institut des sciences biologiques (INSB-CNRS)-Institut des sciences biologiques (INSB-CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR48, Institut des sciences biologiques (INSB-CNRS)-Institut des sciences biologiques (INSB-CNRS)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Istituto Superiore di Sanità (ISS), Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Università degli studi di Genova = University of Genoa (UniGe), Sartelli, Massimo, Kluger, Yoram, Ansaloni, Luca, Carlet, Jean, Dorj, Gereltuya, Catena, Fausto, [Sartelli, Massimo] Macerata Hosp, Dept Surg, Macerata, Italy, [Scibe, Rodolfo] Macerata Hosp, Dept Surg, Macerata, Italy, [Kluger, Yoram] Rambam Hlth Care Campus, Dept Gen Surg, Div Surg, Haifa, Israel, [Ben-Ishay, Ofir] Rambam Hlth Care Campus, Dept Gen Surg, Div Surg, Haifa, Israel, [Ansaloni, Luca] Papa Giovanni XXIII Hosp, Gen Surg Dept, Bergamo, Italy, [Coccolini, Federico] Papa Giovanni XXIII Hosp, Gen Surg Dept, Bergamo, Italy, [Ceresoli, Marco] Papa Giovanni XXIII Hosp, Gen Surg Dept, Bergamo, Italy, [Montori, Giulia] Papa Giovanni XXIII Hosp, Gen Surg Dept, Bergamo, Italy, [Carlet, Jean] World Alliance Antibiot Resistance, Paris, France, [Brink, Adrian] Milpark Hosp, Ampath Natl Lab Serv, Dept Clin Microbiol, Johannesburg, South Africa, [Brink, Adrian] Univ Cape Town, Dept Med, Div Infect Dis & HIV Med, Cape Town, South Africa, [Hardcastle, Timothy C.] Inkosi Albert Luthuli Cent Hosp, Trauma Serv, Durban, South Africa, [Hardcastle, Timothy C.] Nelson R Mandela Sch Clin Med, Dept Surg, Durban, South Africa, [Khanna, Ashish] Ctr Crit Care, Anaesthesiol Inst, Cleveland, OH USA, [Khanna, Ashish] Cleveland Clin, Dept Outcomes Res, Cleveland, OH 44106 USA, [Chicom-Mefire, Alain] Univ Buea, Dept Surg & Obstet Gynaecol, Buea, Cameroon, [Foianini, Esteban] Univ Buea, Dept Surg & Obstet Gynaecol, Buea, Cameroon, [Rodriguez-Bano, Jesus] Hosp Univ Virgen Macarena & Virge del Rocio IbiS, Unidad Clin Interctr Enfermedades Infecciosas Mic, Seville, Spain, [Rodriguez-Bano, Jesus] Univ Seville, Dept Med, Seville, Spain, [Nathwani, Dilip] Ninewells Hosp & Med Sch, Dundee, Scotland, [Mendelson, Marc] Univ Cape Town, Groote Schuur Hosp, Dept Med, Div Infect Dis & HIV Med, Cape Town, South Africa, [Watkins, Richard R.] Cleveland Clin Akron Gen, Div Infect Dis, Akron, OH USA, [Watkins, Richard R.] Northeast Ohio Med Univ, Rootstown, OH USA, [Pulcini, Celine] Lorraine Univ, EA APEMAC 4360, Nancy, France, [Pulcini, Celine] Nancy Univ Hosp, Infect Dis Dept, Nancy, France, [Beovic, Bojana] Univ Med Ctr Ljubljana, Ljubljana, Slovenia, [Beovic, Bojana] Univ Ljubljana, Fac Med, Ljubljana, Slovenia, [May, Addison K.] Vanderbilt Univ, Med Ctr, Div Trauma & Surg Crit Care, Nashville, TN USA, [Itani, Kamal M. F.] Boston Univ, Dept Surg, VA Boston Hlth Care Syst, Boston, MA 02215 USA, [Itani, Kamal M. F.] Harvard Med Sch, Boston, MA USA, [Mazuski, John E.] Washington Univ, Sch Med, Dept Surg, St Louis, MO 63110 USA, [Fry, Donald E.] Northwestern Univ, Feinberg Sch Med, Dept Surg, Chicago, IL 60611 USA, [Fry, Donald E.] Univ New Mexico, Sch Med, Albuquerque, NM 87131 USA, [Rasa, Kemal] Anadolu Med Ctr, Dept Surg, Kocaali, Turkey, [Montravers, Philippe] Bichat Claude Bernard Univ Hosp, Paris Diderot Sorbonne Cite Univ, Anesthesiol & Crit Care Med, HUPNSV, Paris, France, [Eckmann, Christian] Hannover Med Sch, Acad Hosp, Dept Gen Visceral & Thorac Surg, Peine, Germany, [Abbo, Lilian M.] Univ Miami, Miller Sch Med, Jackson Hlth Syst, Div Infect Dis, Miami, FL 33136 USA, [Abbo, Lilian M.] Bayero Univ, Dept Nursing Sci, Kano, Nigeria, [Abubakar, Salisu] UAE Univ, Coll Med & Hlth Sci, Dept Surg, Al Ain, U Arab Emirates, [Abu-Zidan, Fikri M.] Obafemi Awolowo Univ, Coll Hlth Sci, Dept Surg, Ife, Nigeria, [Al-Hasan, Majdi N.] Univ South Carolina, Sch Med, Dept Med, Div Infect Dis, Columbia, SC USA, [Althani, Asma A.] Qatar Univ, Biomed Res Ctr, Doha, Qatar, [Marei, Hany El-Sayed] Qatar Univ, Biomed Res Ctr, Doha, Qatar, [Ticas, Jorge Eduardo Alvarenga] Hosp Nacl Ros, Emergency Unit, San Salvador, El Salvador, [Ansari, Shamshul] Oita Univ, Dept Environm & Prevent Med, Fac Med, Oita, Japan, [Ansari, Shamshul] Chitwan Med Coll, Dept Microbiol, Bharatpur, Nepal, [Ansumana, Rashid] Univ Liverpool, Liverpool Sch Trop Med, Ctr Neglected Trop Dis, Bo, Sierra Leone, [Ansumana, Rashid] Njala Univ, Mercy Hosp, Res Lab, Bo, Sierra Leone, [Araujo da Silva, Andre Ricardo] Prontobaby Hosp Crianca, Infect Control Comm, Rio De Janeiro, Brazil, [Augustin, Goran] Univ Hosp Ctr, Dept Surg, Zagreb, Croatia, [Bala, Miklosh] Hadassah Hebrew Univ Med Ctr, Trauma & Acute Care Surg Unit, Jerusalem, Israel, [Balogh, Zsolt J.] John Hunter Hosp, Dept Traumatol, Newcastle, NSW, Australia, [Balogh, Zsolt J.] Univ Newcastle, Newcastle, NSW, Australia, [Baraket, Oussema] Bizerte Hosp, Dept Surg, Bizerte, Tunisia, [Bassett, Matteo] Santa Maria Misericordia Univ Hosp, Infect Dis Div, Udine, Italy, [Bellanova, Giovanni] SS Annunziata Hosp, Dept Surg, Taranto, Italy, [Beltran, Marcelo A.] Hosp San Juan Dios, Dept Gen Surg, La Serena, Chile, [Biffl, Walter L.] Queens Med Ctr, Acute Care Surg, Honolulu, HI USA, [Boermeester, Marja A.] Acad Med Ctr, Dept Surg, Amsterdam, Netherlands, [Brecher, Stephen M.] Boston Univ, Sch Med, VA Boston HealthCare Syst, Dept Pathol & Lab Med, Boston, MA 02118 USA, [Brecher, Stephen M.] Boston Univ, Sch Med, Dept Pathol & Lab Med, Boston, MA 02118 USA, [Bueno, Juan] Fdn Ctr Invest Bioprospecc & Biotecnol Biodivers, Barranquilla, Colombia, [Cainzos, Miguel A.] Hosp Clin Univ, Dept Surg, Santiago De Compostela, Spain, [Cairns, Kelly] Alfred Hlth, Pharm Dept, Melbourne, Vic, Australia, [Camacho-Ortiz, Adrian] Hosp Univ Dr Jose Eleuterio Gonzalez, Hosp Epidemiol & Infect Dis, Monterrey, Mexico, [Chandy, Sujith J.] Christian Med Coll & Hosp, Dept Pharmacol & Clin Pharmacol, Vellore, Tamil Nadu, India, [Cherry-Bukowiec, Jill R.] Univ Michigan, Dept Surg, Div Acute Care Surg, Ann Arbor, MI 48109 USA, [Cirocchi, Roberto] Univ Perugia, Dept Gen & Oncol Surg, Terni, Italy, [Colak, Elif] Hlth Sci Univ, Samsun Training & Res Hosp, Dept Gen Surg, Samsun, Turkey, [Corcione, Antonio] AORN Colli Vincenzo Monaldi Hosp, Anesthesia & Intens Care Unit, Naples, Italy, [Cornely, Oliver A.] Univ Cologne, German Ctr Infect Res DZIF, Dept Internal Med 1, Cologne Excellence Cluster Cellular Stress Respon, Cologne, Germany, [Cortese, Francesco] San Filippo Neris Hosp, Emergency Surg Unit, Rome, Italy, [Cui, Yunfeng] Tianjin Med Univ, Tianjin Nankai Hosp, Dept Surg, Nankai Clin Sch Med, Tianjin, Peoples R China, [Curcio, Daniel] Buenos Aires Univ, Infectol Inst SRL, Buenos Aires, DF, Argentina, [Damaskos, Dimitris] Royal Infirm Edinburgh NHS Trust, Dept Surg, Edinburgh, Midlothian, Scotland, [Das, Koray] Ankara Numune Training & Res Hosp, Dept Surg, Adana, Turkey, [Delibegovic, Samir] Univ Clin Ctr Tuzla, Dept Surg, Tuzla, Bosnia & Herceg, [Deme-Trashvili, Zaza] Kipshidze Cent Univ Hosp, Dept Gen Surg, Tbilisi, Georgia, [De Simone, Belinda] Cannes Hosp, Dept Digest Surg, Cannes, France, [de Souza, Hamilton Petry] Pontificia Univ Catolica Rio Grande do Sul PUCRS, Sch Med, Dept Surg, Porto Alegre, RS, Brazil, [De Waele, Jan] Ghent Univ Hosp, Dept Crit Care Med, Ghent, Belgium, [Dhingra, Sameer] Univ West Indies, Eric Williams Med Sci Complex, Sch Pharm, Fac Med Sci, Uriah Butler Highway, Champ Fleurs, Trinidad Tobago, [Diaz, Jose J.] Univ Maryland, R Adams Cowley Shock Trauma Ctr, Div Acute Care Surg, Program Trauma, Baltimore, MD 21201 USA, [Di Carlo, Isidoro] Univ Catania, Cannizzaro Hosp, Dept Surg Sci, Catania, Italy, [Di Marzo, Francesco] Versilia Hosp, Gen Surg, Usl Nordovest, Tuscany, Italy, [Di Saverio, Salomone] Maggiore Hosp, Dept Surg, Bologna, Italy, [Dogjani, Agron] Univ Hosp Trauma, Dept Surg, Tirana, Albania, [Dorj, Gereltuya] Mongolian Natl Univ Med Sci, Sch Pharm, Ulaanbaatar, Mongolia, [Dortet, Laurent] Paris Sud Univ, Bicetre Hosp, Dept Microbiol, La Kremlin Bicetre, France, [Duane, Therese M.] John Peter Smith Hlth Network, Dept Surg, Ft Worth, TX USA, [Dupont, Herve] Univ Picardie Jules Verne, CHU Amiens Picardie, Dept Anesthesie Reanimat, Amiens, France, [Dupont, Herve] Univ Picardie Jules Verne, INSERM, U1088, Amiens, France, [Egiev, Valery N.] Pirogov Russian Natl Res Med Univ, Dept Surg, Moscow, Russia, [Eid, Hani O.] Al Ain Hosp, Mediclin Middle East, Dept Emergency Med, Al Ain, U Arab Emirates, [Elmangory, Mutasim] Fed Minist Hlth, Sudan Natl Publ Hlth Lab, Khartoum, Sudan, [Enani, Mushira Abdulaziz] King Fahad Med City, Div Infect Dis, Dept Med, Riyadh, Saudi Arabia, [Escandon-Vargas, Kevin] Univ Valle, Escuela Med, Fac Salud, Cali, Colombia, [Faro Junior, Mario P.] ABC Med Sch, Dept Gen Surg Trauma, Santo Andre, SP, Brazil, [Faro Junior, Mario P.] ABC Med Sch, Emergency Surg Div, Santo Andre, SP, Brazil, [Ferrada, Paula] Virginia Commonwealth Univ, Dept Surg, Richmond, VA USA, [Foghetti, Domitilla] Pesaro Hosp, Dept Surg, Pesaro, Italy, Clin Foianini, Dept Surg, Santa Cruz, Bolivia, [Fraga, Gustavo P.] Univ Campinas Unicamp, Sch Med Sci, Dept Surg, Div Trauma Surg, Campinas, SP, Brazil, [Frattima, Sabrina] Ist Clin San Rocco Franciacorta, Brescia, Italy, [Gandhi, Chinmay] Bharati Vidyapeeth Deemed Univ Med Coll & Hosp, Dept Surg, Sangli, Maharashtra, India, [Gattuso, Gianni] C Poma Hosp, Infect Dis Dept, Mantua, Italy, [Giamarellou, Eleni] Hygeia Gen Hosp, Dept Internal Med 6, Athens, Greece, [Ghnnam, Wagih] Mansoura Univ, Mansoura Fac Med, Dept Gen Surg, Mansoura, Egypt, [Gkiokas, George] Natl & Kapodistrian Univ Athens, Aretaieion Univ Hosp, Dept Surg 2, Athens, Greece, [Girardis, Massimo] Modena Univ Hosp, Intens Care Unit, Modena, Italy, [Goff, Debbie A.] Ohio State Univ, Wexner Med Ctr, Columbus, OH 43210 USA, [Gomes, Carlos Augusto] Hosp Univ Terezinha Jesus, Dept Surg, Fac Ciencias Med & Saude Juiz de Fora, Juiz De Fora, Brazil, [Gomi, Harumi] Univ Tsukuba, Mito Kyodo Gen Hosp, Ctr Global Hlth, Mito, Ibaraki, Japan, [Guerra Gronerth, Rosio Isabel] Peruvian Navy Med Ctr, Lima, Peru, [Guirao, Xavier] Parc Tauli Univ Hosp, Dept Gen Surg, Unit Endocrine Head & Neck Surg, Sabadell, Spain, [Guirao, Xavier] Parc Tauli Univ Hosp, Dept Gen Surg, Unit Surg Infect Support, Sabadell, Spain, [Guzman-Blanco, Manuel] Hosp Privado Ctr Med Caracas, Caracas, Venezuela, [Guzman-Blanco, Manuel] Hosp Vargas Caracas, Caracas, Venezuela, [Haque, Mainul] Univ Pertahanan Nasional Malaysia, Natl Def Univ Malaysia, Unit Pharmacol, Fac Med & Def Hlth, Kuala Lumpur, Malaysia, [Reichert, Martin] Univ Pertahanan Nasional Malaysia, Natl Def Univ Malaysia, Unit Pharmacol, Fac Med & Def Hlth, Kuala Lumpur, Malaysia, [Hecker, Andreas] Univ Hosp Giessen, Dept Gen & Thorac Surg, Giessen, Germany, [Hell, Markus] Paracelsus Med Univ, Acad Teaching Lab, Clin Microbiol & Infect Control, MEDILAB Dr Mustafa Dr Richter OG, Salzburg, Austria, [Herzog, Torsten] Ruhr Univ Bochum, St Josef Hosp, Dept Surg, Bochum, Germany, [Hicks, Lauri] Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA USA, [Kafka-Ritsch, Reinhold] Innsbruck Med Univ, Dept Visceral Transplant & Thorac Surg, Innsbruck, Austria, [Kao, Lillian S.] Univ Texas Hlth Sci Ctr Houston, Dept Surg, Houston, TX 77030 USA, [Kanj, Souha S.] Amer Univ Beirut, Dept Internal Med, Div Infect Dis, Beirut, Lebanon, [Kaplan, Lewis J.] Univ Penn, Perelman Sch Med, Philadelphia VA Med Ctr, Dept Surg, Philadelphia, PA 19104 USA, [Kapoor, Garima] Gandhi Med Coll, Dept Microbiol, Bhopal, India, [Karamarkovic, Aleksandar] Univ Belgrade, Clin Emergency Surg, Med Fac, Belgrade, Serbia, [Kashuk, Jeffry] Tel Aviv Univ, Dept Surg, Assia Med Grp, Sackler Sch Med, Tel Aviv, Israel, [Kenig, Jakub] Jagiellonian Univ, Med Coll, Dept Gen Surg 3, Krakow, Poland, [Khamis, Faryal] Royal Hosp, Dept Internal Med, Muscat, Oman, [Khokha, Vladimir] City Hosp, Dept Emergency Surg, Mozyr, BELARUS, [Kiguba, Ronald] Makerere Univ, Dept Pharmacol & Therapeut, Coll Hlth Sci, Kampala, Uganda, [Kirkpatrick, Andrew W.] Foothills Med Ctr, Gen Acute Care Abdominal Wall Reconstruct & Traum, Calgary, AB, Canada, [Korner, Hartwig] Stavanger Univ Hosp, Dept Gastrointestinal Surg, Stavanger, Norway, [Koike, Kaoru] Kyoto Univ, Grad Sch Med, Dept Primary Care & Emergency Med, Kyoto, Japan, [Kok, Kenneth Y. Y.] Brunei Canc Ctr, Dept Surg, Jerudong Pk, Jerudong, Brunei, [Kon, Kateryna] Kharkiv Natl Med Univ, Dept Microbiol Virol & Immunol, Kharkov, Ukraine, [Kong, Victor] Edendale Hosp, Dept Surg, Pietermaritzburg, South Africa, [Inaba, Kenji] Univ Southern Calif, Los Angeles Cty & Univ So Cali fornia Med Ctr, Div Acute Care Surg & Surg Crit Care, Dept Surg, Los Angeles, CA USA, [Ioannidis, Orestis] Aristotle Univ Thessaloniki, Gen Hosp G Papanikolaou, Surg Dept 4, Med Sch, Thessaloniki, Greece, [Isik, Arda] Erzincan Univ, Dept Gen Surg, Fac Med, Erzincan, Turkey, [Iskandar, Katia] Lebanese Int Univ, Dept Pharm, Beirut, Lebanon, [Labbate, Maurizio] Univ Technol Sydney, Sch Life Sci, Sydney, NSW, Australia, [Labbate, Maurizio] Univ Technol Sydney, Inst I3, Sydney, NSW, Australia, [Labricciosa, Francesco M.] UNIVPM, Dept Biomed Sci & Publ Hlth, Unit Hyg Prevent Med & Publ Hlth, Ancona, Italy, [Lagrou, Katrien] Univ Hosp Leuven, Clin Dept Lab Med, Leuven, Belgium, [Lagrou, Katrien] Katholieke Univ Leuven, Dept Microbiol & Immunol, Leuven, Belgium, [Lagunes, Leonel] Hosp Cent Dr Ignacio Morones Prieto, San Luis Potosi, Mexico, [Latifi, Rifat] Univ Arizona, Dept Surg, Div Trauma, Tucson, AZ USA, [Lasithiotakis, Kostas] York Teaching Hosp NHS Fdn Trust, Dept Surg, York, N Yorkshire, England, [Laxminarayan, Ramanan] Ctr Dis Dynam Econ & Policy, Washington, DC USA, [Lee, Jae Gil] Yonsei Univ, Coll Med, Dept Surg, Seoul, South Korea, [Leone, Marc] Aix Marseille Univ, Hop Nord, AP HM, Dept Anaesthesiol & Crit Care, Marseille, France, [Leppaniemi, Ari] Univ Hosp Meilahti, Abdominal Ctr, Helsinki, Finland, [Li, Yousheng] Shanghai Jiao Tong Univ, Sch Med, Shanghai Peoples Hosp 9, Dept Surg, Shanghai, Peoples R China, [Liang, Stephen Y.] Washington Univ, Sch Med, Div Infect Dis, Div Emergency Med, St Louis, MO USA, [Liau, Kui-Hin] Natl Univ Singapore, Mt Elizabeth Novena Hosp, Singapore & Yong Loo Lin Sch Med, Dept Surg,Liau KH Consulting, Singapore, Singapore, [Litvin, Andrey] Immanuel Kant Balt Fed Univ, Surg Disciplines, Reg Clin Hosp, Kaliningrad, Russia, [Loho, Tonny] Univ Indonesia, Cipto Mangunkusumo Gen Hosp, Dept Clin Pathol, Div Infect Dis,Fac Med, Jakarta, Indonesia, [Lowman, Warren] Univ Witwatersrand, Sch Pathol, Vermaak Partners Pathcare Pathologists, Clin Microbiol & Infect Dis,Fac Hlth Sci, Johannesburg, South Africa, [Lowman, Warren] Wits Donald Gordon Med Ctr, Johannesburg, South Africa, [Machain, Gustavo M.] Univ Nacl Asuncion, Dept Surg, Asuncion, Paraguay, [Segovia Lohse, Helmut] Univ Nacl Asuncion, Dept Surg, Asuncion, Paraguay, [Maier, Ronald V.] Univ Washington, Dept Surg, Seattle, WA 98195 USA, [Manzano-Nunez, Ramiro] Fdn Valle Lili, Clin Res Ctr, Cali, Colombia, [Marinis, Athanasios] Tzane Gen Hosp, Dept Surg 1, Piraeus, Greece, [Marmorale, Cristina] Univ Politecn Marche, Dept Surg, Ancona, Italy, [Martin-Loeches, Ignacio] St James Univ Hosp, Trin Ctr Hlth Sci, Dept Clin Med, Wellcome Trust HRB Clin Res,MICRO, Dublin, Ireland, [Marwah, Sanjay] Postgrad Inst Med Sci, Dept Surg, Rohtak, Haryana, India, [Maseda, Emilio] Hosp Univ La Paz Madrid, Serv Anestesia & Reanimac, Madrid, Spain, [McFarlane, Michael] Univ Hosp West Indies, Dept Surg Radiol, Kingston, Jamaica, [de Melo, Renato Bessa] Ctr Hosp Sao Joao, Gen Surg Dept, Porto, Portugal, [Melotti, Maria Rita] Alma Mater Studiorum Univ Bologna, Dept Med & Surg Sci, Anesthesiol & Intens Care, Bologna, Italy, [Memish, Ziad] Minist Hlth, Prince Mohamed Bin Abdulaziz Hosp, Dept Med, Infect Dis Div, Riyadh, Saudi Arabia, [Mertz, Dominik] McMaster Univ, Dept Med, Hamilton, ON, Canada, [Mertz, Dominik] McMaster Univ, Dept Clin Epidemiol & Biostat, Dept Pathol & Mol Med, Hamilton, ON, Canada, [Mesina, Cristian] Emergency Hosp Craiova, Surg Clin 2, Craiova, Romania, [Menichetti, Francesco] Univ Hosp Pisa, Infect Dis Unit, Pisa, Italy, [Mishra, Shyam Kumar] Tribhuvan Univ, Teaching Hosp, Inst Med, Dept Microbiol, Kathmandu, Nepal, [Moore, Ernest E.] Univ Colorado, Denver Hlth Med Ctr, Dept Surg, Denver, CO 80202 USA, [Moore, Frederick A.] Univ Florida, Coll Med, Dept Surg, Div Acute Care Surg, Gainesville, FL USA, [Moore, Frederick A.] Univ Florida, Coll Med, Ctr Sepsis & Crit Illness Res, Gainesville, FL USA, [Naidoo, Noel] Univ KwaZulu Natal, Dept Surg, Durban, South Africa, [Napolitano, Lena] Univ Michigan, Dept Surg, Ann Arbor, MI 48109 USA, [Negoi, Ionut] Emergency Hosp Bucharest, Dept Surg, Bucharest, Romania, [Nicolau, David P.] Ctr Anti Infect Res & Dev, Hartford, CT USA, [Nikolopoulos, Ioannis] Lewisham & Greenwich NHS Trust, Dept Gen Surg, London, England, [Nord, Carl Erik] Karolinska Univ, Huddinge Hosp, Dept Lab Med, Div Clin Microbiol, Stockholm, Sweden, [Ofori-Asenso, Richard] Hlth Policy Consult, Res Unit, Weija, Accra, Ghana, [Olaoye, Iyiade] Univ Ilorin, Teaching Hosp, Dept Surg, Ilorin, Nigeria, [Omari, Abdelkarim H.] King Abdullah Univ Hosp, Dept Surg, Irbid, Jordan, [Ordonez, Carlos A.] Univ Valle, Fdn Valle Lili, Dept Surg & Crit Care, Cali, Colombia, [Ouadii, Mouaqit] Sidi Mohamed Benabdellah Univ, Hassan Univ Hosp 2, Dept Surg, Med Sch Fez, Fes, Morocco, [Ouedraogo, Abdoul-Salam] CHU Souro Sanou, Bacteriol & Virol Dept, Bobo Dioulasso, Burkina Faso, [Pagani, Leonardo] Bolzano Cent Hosp, Infect Dis Unit, Bolzano, Italy, [Paiva, Jose Artur] Univ Porto, Ctr Hosp Sao Joao, Intens Care Med Dept, Porto, Portugal, [Mergulhao, Paulo] Univ Porto, Ctr Hosp Sao Joao, Intens Care Med Dept, Porto, Portugal, [Parreira, Jose Gustavo] Santa Casa Sao Paulo Sch Med Sci, Dept Surg, Sao Paulo, Brazil, [Pata, Francesco] St Antonio Abate Hosp, Dept Surg, Gallarate, Italy, [Pereira, Jorge] Ctr Hosp Tondela Viseu, Surg Unit 1, Viseu, Portugal, [Pereira, Nuno R.] Sao Joao Hosp Ctr, Ctr Hosp Epidemiol, Unit Prevent & Infect Control, Porto, Portugal, [Petrosillo, Nicola] INMI Lazzaro Spallanzani IRCCS, Natl Inst Infect Dis, Rome, Italy, [Picetti, Edoardo] Univ Parma, Azienda Osped, Dept Anesthesia & Intens Care, Parma, Italy, [Pintar, Tadeja] UMC Ljubljana, Dept Surg, Ljubljana, Slovenia, [Ponce-de-Leon, Alfredo] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Infect Dis, Lab Clin Microbiol, Mexico City, DF, Mexico, [Popovski, Zagorka] Hamilton Hlth Sci, Hamilton, ON, Canada, [Popovski, Zagorka] London Hlth Sci, London, ON, Canada, [Poulakou, Garyphallia] Attikon Univ Gen Hosp, Med Sch, Natl & Kapodistrian Univ Athens, Dept Internal Med 4, Athens, Greece, [Poulakou, Garyphallia] Attikon Univ Gen Hosp, Med Sch, Natl & Kapodistrian Univ Athens, Infect Dis Unit, Athens, Greece, [Preller, Jacobus] Univ Hosp NHS Fdn Trust, John Farman Intens Care Unit, Cambridge, England, [Guerrero, Adrian Puello] Univ Autonoma Santo Domingo, Inst Nacl Canc Rosa Tavares INCART, Santo Domingo, Dominican Rep, [Pupelis, Guntars] Riga East Univ Hosp Gailezers, Dept Gen & Emergency Surg, Riga, Latvia, [Quiodettis, Martha] Hosp Santo Tomas, Dept Trauma, Panama City, Panama, [Rawson, Timothy M.] Natl Inst Hlth Res, Imperial Coll London, Hlth Protect Res Unit Healthcare Associated Infec, Hammersmith Campus, London, England, [Reinhart, Konrad] Jena Univ Hosp, Dept Anesthesiol & Intens Care Med, Jena, Thuringen, Germany, [Rems, Miran] Jesenice Gen Hosp, Dept Gen Surg, Jesenice, Slovenia, [Rello, Jordi] VHIR, Dept Clin Res & Innovat Pneumonia & Sepsis, Barcelona, Spain, [Rizoli, Sandro] Univ Toronto, St Michaels Hosp, Trauma & Acute Care Serv, Toronto, ON, Canada, [Roberts, Jason] Univ Queensland, Fac Med, Brisbane, Qld, Australia, [Rubio-Perez, Ines] La Paz Univ Hosp, Gen Surg Dept, Colorectal Surg Unit, Madrid, Spain, [Ruppc, Etienne] Bichat Claude Bernard Univ Hosp, Paris Diderot Sorbonne Univ, Serv Bacteriol, HUPNSV, Paris, France, [Sakakushev, Boris] Univ Hosp St George, Med Univ, Gen Surg Dept, Plovdiv, Bulgaria, [Sall, Ibrahima] Mil Teaching Hosp, Gen Surg Dept, Dakar, Senegal, [Kafil, Hossein Samadi] Tabriz Univ Med Sci, Drug Appl Res Ctr, Tabriz, Iran, [Sanders, James] JPS Hlth Network, Ft Worth, TX USA, [Sato, Norio] Ehime Univ, Grad Sch Med, Dept Aeromed Serv Emergency & Trauma Care, Matsuyama, Ehime, Japan, [Sawyer, Robert G.] Western Michigan Univ, Sch Med, Dept Surg, Kalamazoo, MI 49008 USA, [Scalea, Thomas] Univ Maryland, Sch Med, Dept Trauma Surg, Baltimore, MD 21201 USA, [Scudeller, Luigia] IRCCS Policlin San Matteo Fdn, Clin Epidemiol Unit, Pavia, Italy, [Sganga, Gabriele] Univ Cattolica Sacro Cuore, Policlin A Gemelli, Dept Surg, Rome, Italy, [Shafiq, Nusrat] Postgrad Inst Med Educ & Res, Dept Pharmacol, Chandigarh, India, [Shah, Jay N.] Patan Acad Hlth Sci, Dept Surg Patan Hosp, Kathmandu, Nepal, [Spigaglia, Patrizia] Ist Super Sanita, Dept Infect Dis, Rome, Italy, [Suroowan, Shanoo] Univ Mauritius, Dept Hlth Sci, Fac Sci, Reduit, Mauritius, [Tsioutis, Constantinos] European Univ Cyprus, Sch Med, Nicosia, Cyprus, [Sifri, Costi D.] Univ Virginia Hlth Syst, Off Hosp Epidemiol Infect Prevent & Control, Charlottesville, VA USA, [Siribumrungwong, Boonying] Thammasat Univ Hosp, Thammasat Univ, Dept Surg, Fac Med, Pathum Thani, Thailand, [Sugrue, Michael] Letterkenny Hosp, Gen Surg Dept, Letterkenny, Ireland, [Talving, Peep] North Estonia Med Ctr, Dept Surg, Tallinn, Estonia, [Tan, Boun Kim] Ctr Hosp St Joseph St Luc, Intens Care Unit, Lyon, France, [Tarasconi, Antonio] Parma Maggiore Hosp, Dept Emergency Surg, Parma, Italy, [Catena, Fausto] Parma Maggiore Hosp, Dept Emergency Surg, Parma, Italy, [Tascini, Carlo] Cotugno Hosp, Azienda Osped Colli, Div Infect Dis 1, Naples, Italy, [Tilsed, Jonathan] Hull & East Yorkshire Hosp NHS Trust, Surg Hlth Care Grp, Kingston Upon Hull, N Humberside, England, [Timsit, Jean-Francois] Hop Xavier Bichat, PHP Med & Infect Dis ICU, Paris, France, [Tumbarello, Mario] Catholic Univ, Inst Infect Dis, Rome, Italy, [Ngo Tat Trung] Tran Hung Dao Hosp, Dept Mol Biol, Hanoi, Vietnam, [Ulrych, Jan] Charles Univ Prague, Fac Med 1, Dept Surg 1, Prague, Czech Republic, [Ulrych, Jan] Gen Univ Hosp Prague, Prague, Czech Republic, [Uranues, Selman] Med Univ Graz, Dept Surg, Graz, Austria, [Velmahos, George] Massachusetts Gen Hosp, Trauma Emergency Surg & Surg Crit Care, Boston, MA 02114 USA, [Vereczkei, Andras G.] Med Sch Univ Pecs, Dept Surg, Pecs, Hungary, [Viale, Pierluigi] Alma Mater Studiorum Univ Bologna, Dept Med & Surg Sci, Infect Dis Unit, Bologna, Italy, [Vila Estape, Jordi] Univ Barcelona, ISGlobal Hosp Clin, Inst Salud Global, Barcelona, Spain, [Viscoli, Claudio] Univ Genoa DISSAL, Osped Policlin San Martino IRCCS Oncol, Infect Dis Unit, Genoa, Italy, [Wagenlehner, Florian] Univ Giessen, Dept Urol Pediat Urol & Androl, Med Fac Justus Liebig, Giessen, Germany, [Wright, Brian J.] SUNY Stony Brook, Sch Med, Dept Emergency Med & Neurosurg, Stony Brook, NY 11794 USA, [Xiao, Yonghong] Zhejiang Univ, Affilliated Hosp 1, State Key Lab Diag & Treatment Infect Dis, Hangzhou, Zhejiang, Peoples R China, [Yuan, Kuo-Ching] Chang Gung Mem Hosp, Trauma & Emergency Surg Dept, Taoyuan, Taiwan, [Zachariah, Sanoop K.] MOSC Med Coll Kolenchery, Dept Surg, Cochin, Kerala, India, [Zahar, Jean Ralph] Angers Univ, CHU Angers, Infect Control Unit, Angers, France, COMBE, Isabelle, Sartelli, M, Kluger, Y, Ansaloni, L, Carlet, J, Brink, A, Hardcastle, T, Khanna, A, Chicom-Mefire, A, Rodriguez-Bano, J, Nathwani, D, Mendelson, M, Watkins, R, Pulcini, C, Beovic, B, May, A, Itani, K, Mazuski, J, Fry, D, Coccolini, F, Rasxa, K, Montravers, P, Eckmann, C, Abbo, L, Abubakar, S, Abu-Zidan, F, Adesunkanmi, A, Al-Hasan, M, Althani, A, Ticas, J, Ansari, S, Ansumana, R, Da Silva, A, Augustin, G, Bala, M, Balogh, Z, Baraket, O, Bassetti, M, Bellanova, G, Beltran, M, Ben-Ishay, O, Biffl, W, Boermeester, M, Brecher, S, Bueno, J, Cainzos, M, Cairns, K, Camacho-Ortiz, A, Ceresoli, M, Chandy, S, Cherry-Bukowiec, J, Cirocchi, R, Colak, E, Corcione, A, Cornely, O, Cortese, F, Cui, Y, Curcio, D, Damaskos, D, Dasx, K, Delibegovic, S, Demetrashvili, Z, De Simone, B, De Souza, H, De Waele, J, Dhingra, S, Diaz, J, Di Carlo, I, Di Marzo, F, Di Saverio, S, Dogjani, A, Dorj, G, Dortet, L, Duane, T, Dupont, H, Egiev, V, Eid, H, Elmangory, M, El-Sayed Marei, H, Enani, M, Escandon-Vargas, K, Faro, M, Ferrada, P, Foghetti, D, Foianini, E, Fraga, G, Frattima, S, Gandhi, C, Gattuso, G, Giamarellou, E, Ghnnam, W, Gkiokas, G, Girardis, M, Goff, D, Gomes, C, Gomi, H, Gronerth, R, Guirao, X, Guzman-Blanco, M, Haque, M, Hecker, A, Hell, M, Herzog, T, Hicks, L, Kafka-Ritsch, R, Kao, L, Kanj, S, Kaplan, L, Kapoor, G, Karamarkovic, A, Kashuk, J, Kenig, J, Khamis, F, Khokha, V, Kiguba, R, Kirkpatrick, A, Korner, H, Koike, K, Kok, K, Kon, K, Kong, V, Inaba, K, Ioannidis, O, Isik, A, Iskandar, K, Labbate, M, Labricciosa, F, Lagrou, K, Lagunes, L, Latifi, R, Lasithiotakis, K, Laxminarayan, R, Lee, J, Leone, M, Leppaniemi, A, Li, Y, Liang, S, Liau, K, Litvin, A, Loho, T, Lowman, W, Machain, G, Maier, R, Manzano-Nunez, R, Marinis, A, Marmorale, C, Martin-Loeches, I, Marwah, S, Maseda, E, Mcfarlane, M, De Melo, R, Melotti, M, Memish, Z, Mertz, D, Mesina, C, Menichetti, F, Mishra, S, Montori, G, Moore, E, Moore, F, Naidoo, N, Napolitano, L, Negoi, I, Nicolau, D, Nikolopoulos, I, Nord, C, Ofori-Asenso, R, Olaoye, I, Omari, A, Ordonez, C, Ouadii, M, Ouedraogo, A, Pagani, L, Paiva, J, Parreira, J, Pata, F, Pereira, J, Pereira, N, Petrosillo, N, Picetti, E, Pintar, T, Ponce-De-Leon, A, Popovski, Z, Poulakou, G, Preller, J, Guerrero, A, Pupelis, G, Quiodettis, M, Rawson, T, Reichert, M, Reinhart, K, Rems, M, Rello, J, Rizoli, S, Roberts, J, Rubio-Perez, I, Ruppe, E, Sakakushev, B, Sall, I, Kafil, H, Sanders, J, Sato, N, Sawyer, R, Scalea, T, Scibe, R, Scudeller, L, Lohse, H, Sganga, G, Shafiq, N, Shah, J, Spigaglia, P, Suroowan, S, Tsioutis, C, Sifri, C, Siribumrungwong, B, Sugrue, M, Talving, P, Tan, B, Tarasconi, A, Tascini, C, Tilsed, J, Timsit, J, Tumbarello, M, Trung, N, Ulrych, J, Uranues, S, Velmahos, G, Vereczkei, A, Viale, P, Estape, J, Viscoli, C, Wagenlehner, F, Wright, B, Xiao, Y, Yuan, K, Zachariah, S, Zahar, J, Mergulhao, P, Catena, F, Sartelli, M., Kluger, Y., Ansaloni, L., Carlet, J., Brink, A., Hardcastle, T. C., Khanna, A., Chicom-Mefire, A., Rodríguez-Baño, J., Nathwani, D., Mendelson, M., Watkins, R. R., Pulcini, C., Beović, B., May, A. K., Itani, K. M. F., Mazuski, J. E., Fry, D. E., Coccolini, F., Rasxa, K., Montravers, P., Eckmann, C., Abbo, L. M., Abubakar, S., Abu-Zidan, F. M., Adesunkanmi, A. K., Al-Hasan, M. N., Althani, A. A., Ticas, J. E. A., Ansari, S., Ansumana, R., Da, Silva, Augustin, A. R. A., Bala, G., Balogh, M., Baraket, Z. J., Bassetti, O., Bellanova, M., Beltran, G., Ben-Ishay, M. A., Boermeester, O., Brecher, M. A., Bueno, S. M., Cainzos, J., Cairns, M. A., Camacho-Ortiz, K., Ceresoli, A., Chandy, M., Cherry-Bukowiec, S. J., Cirocchi, J. R., Colak, R., Corcione, E., Cornely, A., Cortese, O. A., Cui, F., Curcio, Y., Damaskos, D., Dasx, D., Delibegovic, K., Demetrashvili, S., Be, Z., Simone, De, Bf, B., De, Souza, Bg, H. P., De, Waele, Bh, J., Dhingra, Bi, S., Diaz, Bj, J. J., Carlo, Di, Bk, I., Di, Marzo, Bl, F., Saverio, Di, Dogjani, S., Dorj, A., Dortet, G., Duane, L., Dupont, T. M., Egiev, H., Eid, V. N., Elmangory, H. O., El-Sayed, Marei, Enani, H., Escandón-Vargas, M. A., Faro, K., M. P., J. r., Ferrada, P., Foghetti, D., Foianini, E., Fraga, G. P., Frattima, S., Gandhi, C., Gattuso, G., Giamarellou, E., Ghnnam, W., Gkiokas, G., M., Girardi, Goff, D. A., Gomes, C. A., Gomi, H., Gronerth, R. I. G., Guirao, X., Guzman-Blanco, M., Haque, M., Hecker, A., Hell, M., Herzog, T., Hicks, L., Kafka-Ritsch, R., Kao, L. S., Kanj, S. S., Kaplan, L. J., Kapoor, G., Karamarkovic, A., Kashuk, J., Kenig, J., Khamis, F., Khokha, V., Kiguba, R., Kirkpatrick, A. W., Kørner, H., Koike, K., Kok, K. Y. Y., Kon, K., Kong, V., Inaba, K., Ioannidis, O., Isik, A., Iskandar, K., Labbate, M., Labricciosa, F. M., Lagrou, K., Lagunes, L., Latifi, R., Lasithiotakis, K., Laxminarayan, R., Lee, J. G., Leone, M., Leppäniemi, A., Li, Y., Liang, S. Y., Liau, K. -. H., Litvin, A., Loho, T., Lowman, W., Machain, Mf, G., Maier, R. V., Manzano-Nunez, R., Marinis, A., Marmorale, C., Martin-Loeches, I., Marwah, S., Maseda, E., Mcfarlane, M., De, Melo, Melotti, R., Memish, R., Mertz, Z., Mesina, D., Menichetti, C., Mishra, F., Montori, S. K., Moore, G., Moore, E. E., Naidoo, F. A., Napolitano, N., Negoi, L., Nicolau, I., Nikolopoulos, D. P., Nord, I., Ofori-Asenso, C. E., Olaoye, R., Omari, I., Ordoñez, A. H., Ouadii, C. A., Ouedraogo, M., Pagani, A., Paiva, L., Parreira, J. A., Pata, J. G., F., Fm, Pereira, J., Pereira, N. R., Petrosillo, N., Picetti, E., Pintar, T., Ponce-De-Leon, A., Popovski, Z., Poulakou, G., Preller, J., Guerrero, A. P., Pupelis, G., Quiodettis, M., Rawson, T. M., Reichert, M., Reinhart, K., Rems, M., Rello, J., Rizoli, S., Roberts, J., Rubio-Perez, I., Ruppé, E., Sakakushev, B., Sall, I., Kafil, H. S. j, Sanders, J., Sato, N., Sawyer, R. G., Scibé, T., Scudeller, R., Lohse, L., Sganga, H. S., Shafiq, G., Shah, N., Spigaglia, J. N., Suroowan, P., Tsioutis, S., Sifri, C., Siribumrungwong, C. D., Sugrue, B., Talving, M., Tan, P., Tarasconi, B. K., Tascini, A., Tilsed, C., Timsit, J., Tumbarello, J. -. F., Trung, M., Ulrych, N. T., Uranues, J., Velmahos, S., Vereczkei, G., Viale, A. G., Estape, P., Viscoli, J. V., Wagenlehner, C., Wright, F., Xiao, B. J., Yuan, Y., Zachariah, K. -. C., Zahar, S. K., Mergulhão, J. R., and Catena, P.

Subjects
0301 basic medicine, antibiotic agent, antifungal agent antiinfective agent, Antifungal Agents, Drug Resistance, Declaration, Inappropriate Prescribing, 030230 surgery, Global Health, Antimicrobial Stewardship, Microbial, 0302 clinical medicine, Anti-Infective Agents, Health care, Global health, Antimicrobial stewardship, Antibiotic prophylaxis, Antibiotic stewardship, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, Drug Resistance, Microbial, Public relations, Antimicrobial, Operative, Anti-Bacterial Agents, Antibiotic Prophylaxis, Humans, Surgical Procedures, Operative, Surgical Wound Infection, Surgery, Microbiology (medical), Infectious Diseases, 3. Good health, surgical infections, medicine.medical_specialty, 030106 microbiology, Guidelines, 03 medical and health sciences, Antibiotic resistance, medicine, Ventilator-associated pneumonia, Adults, Surgical Procedures, business.industry, Carbapenems, Therapy, business, hospitals, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience; This declaration, signed by an interdisciplinary task force of 234 experts from 83 different countries with different backgrounds, highlights the threat posed by antimicrobial resistance and the need for appropriate use of antibiotic agents and antifungal agents in hospitals worldwide especially focusing on surgical infections. As such, it is our intent to raise awareness among healthcare workers and improve antimicrobial prescribing. To facilitate its dissemination, the declaration was translated in different languages.

Published
2017
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44. Antimicrobials : a global alliance for optimizing their rational use in intra-abdominal infections (AGORA)

Author

Richard R. Watkins, Adrien Hodonou, Brad Spellberg, Fausto Catena, Marc Maegele, Sanoop K. Zachariah, András Vereczkei, Katia Iskandar, Jill R. Cherry-Bukowiec, Jean-Ralph Zahar, Shamshul Ansari, Luca Ansaloni, Addison K. May, Aneel Bhangu, Rao R. Ivatury, Sujith J Chandy, Joseph R Fitchett, Gustavo Pereira Fraga, Peep Talving, Tonny Loho, Amos Massele, Kaoru Koike, Marcelo A. Beltrán, Salomone Di Saverio, Zaza Demetrashvili, Isidoro Di Carlo, Rifat Latifi, Christian Eckmann, Miran Rems, Adrián Camacho-Ortiz, Dieter G. Weber, Majdi N. Al-Hasan, Manuel Guzman-Blanco, Soumitra R. Eachempati, Ravinder S. Vohra, Kjetil Søreide, Etienne Ruppé, Matteo Bassetti, Arda Isik, Andrew W. Kirkpatrick, Hany E. Marei, Gereltuya Dorj, Belinda De Simone, Aleksandar Karamarkovic, Adrian Brink, Jason A. Roberts, Caroline Colijn, Francesco M. Labricciosa, Mainul Haque, Frederick A. Moore, Michael Bernhard, Miguel Caínzos, Ari Leppäniemi, Sara Al-Dahir, Sonja Hansen, Maurizio Labbate, Boonying Siribumrungwong, Hervé Dupont, Rita Maria Melotti, Helen Giamarellou, Vishal G Shelat, Martin G. Kees, Rodolfo Soto, F. Corcione, Michael McFarlane, Kenji Inaba, Samir Delibegovic, Kuo Ching Yuan, David P. Nicolau, Gerson Alves Pereira Júnior, Jose J. Diaz, Dominik Mertz, Claudio Viscoli, Lewis J. Kaplan, George Gkiokas, Torsten Herzog, Alain Chichom-Mefire, Agron Dogjani, Jan Ulrych, Jan J. De Waele, Jean-François Timsit, Warren Lowman, Yunfeng Cui, Asmaa Althani, Yousheng Li, Diego Piazza, Staphanie R. Goldberg, Yoram Kluger, Carlos A. Ordoñez, Carl Erik Nord, Waldemar Uhl, O.R. Buyne, Imtiaz Wani, Wolfgang R. Heizmann, Valery N. Egiev, Timothy M. Rawson, Abdel K. Omari, Renato Bessa Melo, A R K Adesunkanmi, Miguel Sanchez-Garcia, Pierre-François Laterre, Vladimir Khokha, Harumi Gomi, Massimo Sartelli, Boris Sakakhushev, Ewen A. Griffiths, Ngo Tat Trung, Young R. Lee, Tanya L. Zakrison, Mushira Enani, Ignacio Martin-Loeches, Gabriele Sganga, Ionut Negoi, Carlos Augusto Gomes, Jakub Kenig, Ronald V. Maier, Norio Sato, Gabriel Trueba, Kelly A. Cairns, Claudio Rocha, Anand Kumar, Andreas Hecker, Fikri M. Abu-Zidan, Marja A. Boermeester, Michael P. Doyle, Peter K. Kim, Federico Coccolini, Paula Ferrada, Sandro Rizoli, Stephen M. Brecher, Robert G. Sawyer, Victory Kong, Jean Louis Vincent, Goran Augustin, Suk-Kyung Hong, Stephen Y. Liang, Helmut Alfredo Segovia Lohse, Walter L. Biffl, Reinhold Kafka-Ritsch, Jae Gil Lee, Ernest E. Moore, Sameer Dhingra, Miklosh Bala, Sydney Malama, Kenneth Y.Y. Kok, Oussama Baraket, Harry van Goor, Garima Kapoor, Philippe Montravers, Iain J. Abbott, Wagih Ghnnam, Angel Dillip, Raul Coimbra, Sanjay Marwah, Mouaqit Ouadii, Zsolt J. Balogh, Nathalie Guessennd, Richard Ofori-Asenso, Jonathan Tilsed, Antonio Corcione, Daniel Curcio, Marc Leone, Guntars Pupelis, Yonghong Xiao, Ferdinando Agresta, Mutasim M. Elmangory, Brian J. Wright, John E. Mazuski, Asri Che Jusoh, Perluigi Viale, Ronald Kiguba, Rashid Ansumana, Matthew C Knox, CHU Amiens-Picardie, 6th Department of Internal Medicine, Diagnostic and Therapeutic Center of Athens 'Hygeia', Department of Anesthesiology and Intensive Care, Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes (URMITE), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR48, Institut des sciences biologiques (INSB-CNRS)-Institut des sciences biologiques (INSB-CNRS)-Centre National de la Recherche Scientifique (CNRS), Hartford Hospital, Department of Laboratory Medicine, Karolinska Institutet [Stockholm], Equipe mobile d'infectiologie, CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service Microbiologie-Hygiène Hospitalière, Infectious Diseases, Università degli studi di Genova = University of Genoa (UniGe), Service d'anesthésie - réanimation chirurgicale [CHU Bichat], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), Université libre de Bruxelles (ULB), Sartelli, Massimo, Weber, Dieter G., Ruppé, Etienne, Bassetti, Matteo, Wright, Brian J., Ansaloni, Luca, Catena, Fausto, Coccolini, Federico, Abu-Zidan, Fikri M., Coimbra, Raul, Moore, Ernest E., Moore, Frederick A., Maier, Ronald V., De Waele, Jan J., Kirkpatrick, Andrew W., Griffiths, Ewen A., Eckmann, Christian, Brink, Adrian J., Mazuski, John E., May, Addison K., Sawyer, Rob G., Mertz, Dominik, Montravers, Philippe, Kumar, Anand, Roberts, Jason A., Vincent, Jean-Loui, Watkins, Richard R., Lowman, Warren, Spellberg, Brad, Abbott, Iain J., Adesunkanmi, Abdulrashid Kayode, Al-Dahir, Sara, Al-Hasan, Majdi N., Agresta, Ferdinando, Althani, Asma A., Ansari, Shamshul, Ansumana, Rashid, Augustin, Goran, Bala, Miklosh, Balogh, Zsolt J., Baraket, Oussama, Bhangu, Aneel, Beltrán, Marcelo A., Bernhard, Michael, Biffl, Walter L., Boermeester, Marja A., Brecher, Stephen M., Cherry-Bukowiec, Jill R., Buyne, Otmar R., Cainzos, Miguel A., Cairns, Kelly A., Camacho-Ortiz, Adrian, Chandy, Sujith J., Che Jusoh, Asri, Chichom-Mefire, Alain, Colijn, Caroline, Corcione, Francesco, Cui, Yunfeng, Curcio, Daniel, Delibegovic, Samir, Demetrashvili, Zaza, De Simone, Belinda, Dhingra, Sameer, Diaz, José J., Di Carlo, Isidoro, Dillip, Angel, Di Saverio, Salomone, Doyle, Michael P., Dorj, Gereltuya, Dogjani, Agron, Dupont, Hervé, Eachempati, Soumitra R., Enani, Mushira Abdulaziz, Egiev, Valery N., Elmangory, Mutasim M., Ferrada, Paula, Fitchett, Joseph R., Fraga, Gustavo P., Guessennd, Nathalie, Giamarellou, Helen, Ghnnam, Wagih, Gkiokas, George, Goldberg, Staphanie R., Gomes, Carlos Augusto, Gomi, Harumi, Guzmán-Blanco, Manuel, Haque, Mainul, Hansen, Sonja, Hecker, Andrea, Heizmann, Wolfgang R., Herzog, Torsten, Hodonou, Adrien Montcho, Hong, Suk-Kyung, Kafka-Ritsch, Reinhold, Kaplan, Lewis J., Kapoor, Garima, Karamarkovic, Aleksandar, Kees, Martin G., Kenig, Jakub, Kiguba, Ronald, Kim, Peter K., Kluger, Yoram, Khokha, Vladimir, Koike, Kaoru, Kok, Kenneth Y. Y., Kong, Victory, Knox, Matthew C., Inaba, Kenji, Isik, Arda, Iskandar, Katia, Ivatury, Rao R., Labbate, Maurizio, Labricciosa, Francesco M., Laterre, Pierre-Françoi, Latifi, Rifat, Lee, Jae Gil, Lee, Young Ran, Leone, Marc, Leppaniemi, Ari, Li, Yousheng, Liang, Stephen Y., Loho, Tonny, Maegele, Marc, Malama, Sydney, Marei, Hany E., Martin-Loeches, Ignacio, Marwah, Sanjay, Massele, Amo, Mcfarlane, Michael, Melo, Renato Bessa, Negoi, Ionut, Nicolau, David P., Nord, Carl Erik, Ofori-Asenso, Richard, Omari, AbdelKarim H., Ordonez, Carlos A., Ouadii, Mouaqit, Pereira Júnior, Gerson Alve, Piazza, Diego, Pupelis, Guntar, Rawson, Timothy Mile, Rems, Miran, Rizoli, Sandro, Rocha, Claudio, Sakakhushev, Bori, Sanchez-Garcia, Miguel, Sato, Norio, Segovia Lohse, Helmut A., Sganga, Gabriele, Siribumrungwong, Boonying, Shelat, Vishal G., Soreide, Kjetil, Soto, Rodolfo, Talving, Peep, Tilsed, Jonathan V., Timsit, Jean-Francoi, Trueba, Gabriel, Trung, Ngo Tat, Ulrych, Jan, van Goor, Harry, Vereczkei, Andra, Vohra, Ravinder S., Wani, Imtiaz, Uhl, Waldemar, Xiao, Yonghong, Yuan, Kuo-Ching, Zachariah, Sanoop K., Zahar, Jean-Ralph, Zakrison, Tanya L., Corcione, Antonio, Melotti, Rita M., Viscoli, Claudio, Viale, Perluigi, UCL - SSS/IREC/MEDA - Pôle de médecine aiguë, UCL - (SLuc) Service de soins intensifs, INSB-INSB-Centre National de la Recherche Scientifique (CNRS), University of Genoa (UNIGE), Sartelli, M, Weber, DG, Ruppe, E, Bassetti, M, Dorj, G, Kok, Kenneth Y.Y., and Viale, Pierluigi

Subjects
Anti-Infective Agent, 0301 basic medicine, INTENSIVE-CARE-UNIT, International Cooperation, Settore MED/18 - CHIRURGIA GENERALE, Drug Resistance, morbidity, Review, Drug resistance, Tigecycline, CLOSTRIDIUM-DIFFICILE INFECTION, VANCOMYCIN-RESISTANT ENTEROCOCCI, Microbial, SPECTRUM-BETA-LACTAMASE, 0302 clinical medicine, Anti-Infective Agents, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Medicine and Health Sciences, Agora, 030212 general & internal medicine, wb_330, computer.programming_language, Iais, biology, Microbial Sensitivity Test, Antimicrobials, Drug Resistance, Microbial, Antimicrobials, (AGORA), Prognosis, Antimicrobial, 3. Good health, CARBAPENEMASE-PRODUCING ENTEROBACTERIACEAE, antibiotic-resistance, Intra-abdominal infections (IAI), Surgery, Emergency Medicine, CLINICAL-PRACTICE GUIDELINES, 7c0bbdab, BLOOD-STREAM INFECTIONS, CRITICALLY-ILL PATIENTS, Human, medicine.drug, medicine.medical_specialty, Prognosi, 030106 microbiology, Microbial Sensitivity Tests, wa_110, qw_45, Emerging and Re-emerging Infectious Diseases, 03 medical and health sciences, wi_140, Antibiotic resistance, Intraabdominal Infection, medicine, Humans, intra-abdominal infections, GRAM-NEGATIVE BACTERIA, Intensive care medicine, Chirurgie, VENTILATOR-ASSOCIATED PNEUMONIA, business.industry, Médecine pathologie humaine, Intraabdominal Infections, biology.organism_classification, Review article, Reconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10], business, computer
Abstract

Intra-abdominal infections (IAI) are an important cause of morbidity and are frequently associated with poor prognosis, particularly in high-risk patients. The cornerstones in the management of complicated IAIs are timely effective source control with appropriate antimicrobial therapy. Empiric antimicrobial therapy is important in the management of intra-abdominal infections and must be broad enough to cover all likely organisms because inappropriate initial antimicrobial therapy is associated with poor patient outcomes and the development of bacterial resistance. The overuse of antimicrobials is widely accepted as a major driver of some emerging infections (such as C. difficile), the selection of resistant pathogens in individual patients, and for the continued development of antimicrobial resistance globally. The growing emergence of multi-drug resistant organisms and the limited development of new agents available to counteract them have caused an impending crisis with alarming implications, especially with regards to Gram-negative bacteria. An international task force from 79 different countries has joined this project by sharing a document on the rational use of antimicrobials for patients with IAIs. The project has been termed AGORA (Antimicrobials: A Global Alliance for Optimizing their Rational Use in Intra-Abdominal Infections). The authors hope that AGORA, involving many of the world's leading experts, can actively raise awareness in health workers and can improve prescribing behavior in treating IAIs., 0, SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2016
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45. Tigecycline in the treatment of ventilator-associated pneumonia: experience from the Latin American Tigecycline Use Registry.

Author

Curcio D, Castagnino J, Vazquez W, Vergara G, and Curiale A

Subjects
Adolescent, Adult, Aged, Aged, 80 and over, Drug Evaluation, Drug Resistance, Multiple, Bacterial, Drug Utilization statistics & numerical data, Female, Hospital Mortality, Hospital Records statistics & numerical data, Humans, Intensive Care Units statistics & numerical data, Latin America epidemiology, Male, Middle Aged, Minocycline therapeutic use, Pneumonia, Ventilator-Associated epidemiology, Prospective Studies, Registries statistics & numerical data, Tigecycline, Treatment Outcome, Young Adult, Anti-Bacterial Agents therapeutic use, Minocycline analogs & derivatives, Pneumonia, Ventilator-Associated drug therapy
Abstract

Objective: The aim of this study was to evaluate the clinical success rate of the patients with ventilator-associated pneumonia (VAP) treated with tigecycline., Methods: Data from patients with established criteria of VAP were collected using a web-based reporting system from 16 February, 2006 to June 23, 2009. One hundred and seventeen patients coming from 10 ICUs from Argentina were studied., Results: Overall, attending physician reported clinical success in 74 patients (63%; 95%CI 54.08-72.41%). Global mortality proportion was 33% (39/117 patients). Patients with APACHE II score at admission > or = 15 showed a clinical success rate significantly lower and a mortality rate significantly higher than those with APACHE II score at admission less than 15 (52.6% [30/57] vs 73.3% [44/60]; p 0.0332, and 45.6% [26/57]vs 21.7% [13/60]; p 0.0108). The etiology of VAP was established in 60 patients (51%). Acinetobacter spp. (59%; in 84% of cases carbapenems-resistant), and methicillin-resistant Staphylococcus aureus (22%) were the most common microorganisms isolated. Eleven patients (1.5%) had VAP with bacteremia (respiratory sample and blood cultures positive for the same pathogens)., Conclusions: As initial evidence, our results suggest that tigecycline may be an acceptable alternative for therapy in patients with VAP. Nevertheless, only controlled clinical trials will provide the evidence to support approval for new indications.

Published
2010

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