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1. Recommendations on presenting LHC searches for missing transverse energy signals using simplified s-channel models of dark matter

Author

Boveia, A, Buchmueller, O, Busoni, G, D'Eramo, F, De Roeck, A, De Simone, A, Doglioni, C, Dolan, MJ, Genest, MH, Hahn, K, Haisch, U, Harris, PC, Heisig, J, Ippolito, V, Kahlhoefer, F, Khoze, VV, Kulkarni, S, Landsberg, G, Lowette, S, Malik, S, Mangano, M, McCabe, C, Mrenna, S, Pani, P, du Pree, T, Riotto, A, Salek, D, Schmidt-Hoberg, K, Shepherd, W, Tait, TMP, Wang, LT, Worm, S, and Zurek, K

Subjects
hep-ex, hep-ph, Astronomical and Space Sciences, Atomic, Molecular, Nuclear, Particle and Plasma Physics, Atomic, Molecular, Nuclear, Particle and Plasma Physics
Abstract

This document summarises the proposal of the LHC Dark Matter Working Group on how to present LHC results on s-channel simplified dark matter models and to compare them to direct (indirect) detection experiments.

Published
2020

2. Dark Matter benchmark models for early LHC Run-2 Searches: Report of the ATLAS/CMS Dark Matter Forum

Author

Abercrombie, D, Akchurin, N, Akilli, E, Maestre, JA, Allen, B, Gonzalez, BA, Andrea, J, Arbey, A, Azuelos, G, Azzi, P, Backović, M, Bai, Y, Banerjee, S, Beacham, J, Belyaev, A, Boveia, A, Brennan, AJ, Buchmueller, O, Buckley, MR, Busoni, G, Buttignol, M, Cacciapaglia, G, Caputo, R, Carpenter, L, Castro, NF, Ceballos, GG, Cheng, Y, Chou, JP, Gonzalez, AC, Cowden, C, D'Eramo, F, De Cosa, A, De Gruttola, M, De Roeck, A, De Simone, A, Deandrea, A, Demiragli, Z, DiFranzo, A, Doglioni, C, du Pree, T, Erbacher, R, Erdmann, J, Fischer, C, Flaecher, H, Fox, PJ, Fuks, B, Genest, MH, Gomber, B, Goudelis, A, Gramling, J, Gunion, J, Hahn, K, Haisch, U, Harnik, R, Harris, PC, Hoepfner, K, Hoh, SY, Hsu, DG, Hsu, SC, Iiyama, Y, Ippolito, V, Jacques, T, Ju, X, Kahlhoefer, F, Kalogeropoulos, A, Kaplan, LS, Kashif, L, Khoze, VV, Khurana, R, Kotov, K, Kovalskyi, D, Kulkarni, S, Kunori, S, Kutzner, V, Lee, HM, Lee, SW, Liew, SP, Lin, T, Lowette, S, Madar, R, Malik, S, Maltoni, F, Perez, MM, Mattelaer, O, Mawatari, K, McCabe, C, Megy, T, Morgante, E, Mrenna, S, Moon, CS, Narayanan, SM, Nelson, A, Novaes, SF, Padeken, KO, Pani, P, Papucci, M, Paulini, M, Paus, C, Pazzini, J, and Penning, B

Subjects
Dark Matter, Simplified models, EFT, LHC, hep-ex, hep-ph, Astronomical and Space Sciences, Atomic, Molecular, Nuclear, Particle and Plasma Physics
Abstract

This document is the final report of the ATLAS-CMS Dark Matter Forum, a forum organized by the ATLAS and CMS collaborations with the participation of experts on theories of Dark Matter, to select a minimal basis set of dark matter simplified models that should support the design of the early LHC Run-2 searches. A prioritized, compact set of benchmark models is proposed, accompanied by studies of the parameter space of these models and a repository of generator implementations. This report also addresses how to apply the Effective Field Theory formalism for collider searches and present the results of such interpretations.

Published
2020

3. Saxion cosmology for thermalized gravitino dark matter

Author

Co, RT, D’Eramo, F, Hall, LJ, and Harigaya, K

Subjects
Beyond Standard Model, Cosmology of Theories beyond the SM, Supersym-metric Standard Model, Nuclear & Particles Physics, Mathematical Sciences, Physical Sciences, Mathematical Physics, Atomic, Molecular, Nuclear, Particle and Plasma Physics, Quantum Physics, Atomic, Molecular, Nuclear, Particle and Plasma Physics
Abstract

In all supersymmetric theories, gravitinos, with mass suppressed by the Planck scale, are an obvious candidate for dark matter; but if gravitinos ever reached thermal equilibrium, such dark matter is apparently either too abundant or too hot, and is excluded. However, in theories with an axion, a saxion condensate is generated during an early era of cosmological history and its late decay dilutes dark matter. We show that such dilution allows previously thermalized gravitinos to account for the observed dark matter over very wide ranges of gravitino mass, keV < m3/2 < TeV, axion decay constant, 109 GeV < fa < 1016 GeV, and saxion mass, 10 MeV < ms < 100 TeV. Constraints on this parameter space are studied from BBN, supersymmetry breaking, gravitino and axino production from freeze-in and saxion decay, and from axion production from both misalignment and parametric resonance mechanisms. Large allowed regions of (m3/2, fa, ms) remain, but differ for DFSZ and KSVZ theories. Superpartner production at colliders may lead to events with displaced vertices and kinks, and may contain saxions decaying to (WW, ZZ, hh), gg, γγ or a pair of Standard Model fermions. Freeze-in may lead to a sub-dominant warm component of gravitino dark matter, and saxion decay to axions may lead to dark radiation.

Published
2017

4. Síntesis y almacenamiento de carga de la nueva aleación polipirrol/poli(ácido maleico-olefina)

Author

D´eramo, F. and Otero, T. F.

Subjects
Polypyrrole, poly (maleic acid-co-olefin), synthesis, Polipirrol, poli(ácido maléico-co-olefina), síntesis, Clay industries. Ceramics. Glass, TP785-869
Abstract

The influence that the electrosynthesis conditions of the polypyrrole/poly(maleic acid-co-olefin) blend have on the charge storage ability (amount of electrical charge stored (mC) per unit mass (mg) of electrogenerated polymer) has been analysed. This is the initial step for the optimisation, pyrrole and poly (maleic acid-co-olefin) concentrations and the polymerisation temperature have been the studied parameters. Optimising these ones, we could obtain materials with average storage charge of 120mc.mg-1.Se ha analizado la influencia de diversas variables de síntesis sobre la capacidad de almacenamiento de carga (mC de carga almacenada / mg de polímero electrogenerado) de aleaciones poliméricas de polipirrol/poli(ácido maléico-co-olefina), como paso inicial para la optimación de este material para su aplicación en baterías todo orgánicas. Las variables de estudio han sido: el potencial y el tiempo de polimerización, las concentraciones de pirrol y poli(ácido maléico-co-olefina) y la temperatura de la solución de polimerización. Optimando estos parámetros se ha logrado sintetizar materiales con una capacidad promedio de almacenamiento de carga de 120 mC. mg-1.

Published
2000

5. Cosmic imprints of XENON1T axions

Author

Arias-Aragón, F., D'Eramo, F., Ferreira, Ricardo Z., Merlo, L., Notari, A., Arias-Aragón, F., D'Eramo, F., Ferreira, Ricardo Z., Merlo, L., and Notari, A.

Abstract

The recent electron recoil excess observed by XENON1T has a possible interpretation in terms of solar axions coupled to electrons. If such axions are still relativistic at recombination they would also leave a cosmic imprint in the form of an additional radiation component, parameterized by an effective neutrino number Δ Neff. We explore minimal scenarios with a detectable signal in future CMB surveys: axions coupled democratically to all fermions, axion-electron coupling generated radiatively, the DFSZ framework for the QCD axion. The predicted Δ Neff is larger than 0.03-0.04 for all cases, close to the 2σ forecasted sensitivity of CMB-S4 experiments. This opens the possibility of testing with cosmological observations the solar axion interpretation of the XENON1T excess., QC 20210223

Published
2020
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6. Estudio petrográfico, espectral y de susceptibilidad magnética de la alteración hidrotermal asociada con depósitos polimetálicos de Pb-Zn-Cu-Ag-Au, Sierra de Comechingones, Córdoba (Argentina)

Author

Maffini, M. N., primary, Ducart, D. F., additional, Radice, S., additional, Coniglio, J., additional, D’Eramo, F., additional, Demartis, M., additional, Pinotti, L., additional, Moreira Silva, A., additional, and Bemfica Toledo, C. L., additional

Published
2017
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7. Magnetic fabric and emplacement of the Alpa Corral plutón (Sierras de Córdoba, Argentina)

Author

Pinotti, Lucio P., D'Eramo, F., Coniglio, Jorge E., Aranguren, A., and Tubía, José María

Subjects
Granite, Argentina, Emplacement, Sierras Pampeanas, Magnetic fabric
Abstract

Nearly circular in outcrop, the Alpa Corral plutón is one of the post-tectonic monzogranitic plutons of the Sierras Pampeanas, in Córdoba (Argentina). This pluton intrudes the Early Paleozoic basement of the Sierras Pampeanas during Late Devonian times. This concentrically zoned pluton is made up by inequigranular to porphyritic monzogranites, distributed in two units: a internal unit formed by coarse to porphyritic granite and a external unit represented by inequigranular leucogranite. Bulk magnetic susceptibility (K) shows bimodal distribution, reflecting magnetite-rich granites for the internal unit and magnetite-poor to paramagnetic granites within external unit. Microstructural evidence indicates that magnetic fabrics are entirely magmatic in origin and reflect the internal magma dynamics. From structural and Anisotropy of Magnetic Susceptibility measurements, the internal structure of this pluton has been inferred. According to the AMS and structural data from the country rocks, the emplacement of the Alpa Corral pluton took place after the vanishement of the compresional stress field responsible for the main structures recorded in the country rocks. However, some control by a far field stress can be deduced from the NNW-SSE alignment of the post-tectonic plutons of the Sierras Pampeanas. This suggests that granite emplacement was controlled by a set of early master fractures related to the extensional collapse in this sector of the Sierras Pampeanas

Published
2003

8. Tectono-magmatic response to major convergence changes in the North Patagonian suprasubduction system; the Paleogene subduction-transcurrent plate margin transition

Author

Aragón, E., D'Eramo, F., Castro, A., Pinotti, L., Brunelli, D., Rabbia, O., Rivalenti, G., Varela, R., Spakman, W., Demartis, M., Cavarozzi, C.E., Aguilera, Y.E., Mazzucchelli, M., Ribot, A., Aragón, E., D'Eramo, F., Castro, A., Pinotti, L., Brunelli, D., Rabbia, O., Rivalenti, G., Varela, R., Spakman, W., Demartis, M., Cavarozzi, C.E., Aguilera, Y.E., Mazzucchelli, M., and Ribot, A.

Published
2011

9. Top-down structures of mafic enclaves within the Valle Fértil magmatic complex (Early Ordovician, San Juan, Argentina)

Author

Castro Dorado, Antonio, Otamendi, J., Pinotti, L. P., D'Eramo, F. J., Martino, R., Vujovich, G., Tibaldi, A., Viñao, A., Castro Dorado, Antonio, Otamendi, J., Pinotti, L. P., D'Eramo, F. J., Martino, R., Vujovich, G., Tibaldi, A., and Viñao, A.

Abstract

Magmatic structures related to the mechanical interaction between mafic magmas and granitoids have been studied in the Valle Fértil calc-alkaline igneous complex, Argentina. Excepcional outcrops with vertical walls of more than 300 m high allow us the study of three-dimensional geometries of individual blobs of mafic magma as well as the geometry of pipe-like structures in which mafic microgranular enclaves are concentrated in more than 50 times the normal abundance in the granodiorite mass. The shape of enclaves and pipe-like structures are interpreted as the ressult of top-to-down intrusions of a mafic magma into a granodiorite-tonalite mass. These sinking structures are the result of a reverselly stratified magma chamber with gabbros and diorites at the top and granodiorite-tonalite at the bottom. They may account for most of the structures found in microgranular enclaves and magma mingling zones that characterize calc-alkaline batholiths. Synplutonic intrusions from the top is the only plausible mechanism to account for the observed structures. The model may be of general application to calc-alkaline batholiths characterized by the presence of mafic microgranular enclaves. An implication of these reverselly stratified magma chambers is the presence of a petrological inversion which may be the consequence of cold diapirs emplaced below the mantle wedge in a suprasubduction setting.

Published
2008

10. Incorporation and voltammetric determination of silver (I) at an electrode electrochemically modified with a poly-benzidine film

Author

D'Eramo, F., Arévalo, A.H., Silber, J.J., and Sereno, L.

Subjects
modified electrodes, poly-benzidine, electroanalysis, silver(I)
Abstract

Electrodes modified with poly-benzidine films are chemically stable in the pH range between 0 and 7, and can be cycled from -0.200 to 0.850 V with no evidence of decomposition. Consequently, in this potential range, they can be used as electrode material for oxidation or reduction of different species. One interesting property of this modified electrode is its capacity to capture and quantify Ag(I) ion present in solution. To obtain reproducible results, the accumulation step was carried out in a AgNO3 solution with acetate buffer at pH = 7. After reduction to Ag(0) in the same solution, the determination step was performed by cyclic voltammetry. The analytical response corresponds to silver oxidation to Ag(I), and the amount of silver incorporated into the film was determined from the charge of the anodic peak. The potential use of this method for analytical determination of silver is discussed. Eletrodos modificados com filmes de poli-bendizina são quimicamente estáveis no intervalo de pH entre 0 e 7 e podem ser ciclados de -0.200 a 0.850 V sem evidência de decomposição. Conseqüentemente, neste intervalo de potencial, eles podem ser usados como material eletródico para a oxidação ou redução de diferentes espécies. Uma propriedade interessante deste eletrodo modificado é sua capacidade de capturar e quantificar o íon Ag(I) presente na solução. Para obter resultados reproduzíveis a etapa de acumulação foi realizada numa solução de AgNO3 com um tampão de acetato de pH = 7. Após redução para Ag(0) na mesma solução, a etapa de determinação foi executado por voltametria cíclica. A resposta analítica corresponde à oxidação para Ag(I) e a quantia de prata incorporada ao filme foi determinada a partir da carga do pico anódico. O uso potencial deste método para a determinação analítica da prata é discutido.

Published
1997

11. Síntesis y almacenamiento de carga de la nueva aleación polipirrol/poli(ácido maleico-olefina)

Author

Eramo, F. D., Otero, T. F., Eramo, F. D., and Otero, T. F.

Abstract

Se ha analizado la influencia de diversas variables de síntesis sobre la capacidad de almacenamiento de carga (mC de carga almacenada / mg de polímero electrogenerado) de aleaciones poliméricas de polipirrol/poli(ácido maléico-co-olefina), como paso inicial para la optimación de este material para su aplicación en baterías todo orgánicas. Las variables de estudio han sido: el potencial y el tiempo de polimerización, las concentraciones de pirrol y poli(ácido maléico-co-olefina) y la temperatura de la solución de polimerización. Optimando estos parámetros se ha logrado sintetizar materiales con una capacidad promedio de almacenamiento de carga de 120 mC. mg-1.

Published
2000

14. Top-down structures of mafic enclaves within the Valle Fértil magmatic complex (Early Ordovician, San Juan, Argentina)

Author

Antonio Castro, Martino, R., Vujovich, G., Otamendi, J., Pinotti, L., D Eramo, F., Tibaldi, A., and Viñao, A.

Subjects
Enclaves, Calc-alkaline batholiths, Argentina, Synplutonic intrusions, Famatinian belt
Abstract

Magmatic structures related to the mechanical interaction between mafic magmas and granitoids have been studied in the Valle Fértil calc-alkaline igneous complex, Argentina. Excepcional outcrops with vertical walls of more than 300 m high allow us the study of three-dimensional geometries of individual blobs of mafic magma as well as the geometry of pipe-like structures in which mafic microgranular enclaves are concentrated in more than 50 times the normal abundance in the granodiorite mass. The shape of enclaves and pipe-like structures are interpreted as the ressult of top-to-down intrusions of a mafic magma into a granodiorite-tonalite mass. These sinking structures are the result of a reverselly stratified magma chamber with gabbros and diorites at the top and granodiorite-tonalite at the bottom. They may account for most of the structures found in microgranular enclaves and magma mingling zones that characterize calc-alkaline batholiths. Synplutonic intrusions from the top is the only plausible mechanism to account for the observed structures. The model may be of general application to calc-alkaline batholiths characterized by the presence of mafic microgranular enclaves. An implication of these reverselly stratified magma chambers is the presence of a petrological inversion which may be the consequence of cold diapirs emplaced below the mantle wedge in a suprasubduction setting.

15. Dark Matter Benchmark Models for Early LHC Run-2 Searches: Report of the ATLAS/CMS Dark Matter Forum

Author

Daniel Abercrombie, Nural Akchurin, Ece Akilli, Juan Alcaraz Maestre, Brandon Allen, Barbara Alvarez Gonzalez, Jeremy Andrea, Alexandre Arbey, Georges Azuelos, Patrizia Azzi, Mihailo Backović, Yang Bai, Swagato Banerjee, James Beacham, Alexander Belyaev, Antonio Boveia, Amelia Jean Brennan, Oliver Buchmueller, Matthew R. Buckley, Giorgio Busoni, Michael Buttignol, Giacomo Cacciapaglia, Regina Caputo, Linda Carpenter, Nuno Filipe Castro, Guillelmo Gomez Ceballos, Yangyang Cheng, John Paul Chou, Arely Cortes Gonzalez, Chris Cowden, Francesco D’Eramo, Annapaola De Cosa, Michele De Gruttola, Albert De Roeck, Andrea De Simone, Aldo Deandrea, Zeynep Demiragli, Anthony DiFranzo, Caterina Doglioni, Tristan du Pree, Robin Erbacher, Johannes Erdmann, Cora Fischer, Henning Flaecher, Patrick J. Fox, Benjamin Fuks, Marie-Helene Genest, Bhawna Gomber, Andreas Goudelis, Johanna Gramling, John Gunion, Kristian Hahn, Ulrich Haisch, Roni Harnik, Philip C. Harris, Kerstin Hoepfner, Siew Yan Hoh, Dylan George Hsu, Shih-Chieh Hsu, Yutaro Iiyama, Valerio Ippolito, Thomas Jacques, Xiangyang Ju, Felix Kahlhoefer, Alexis Kalogeropoulos, Laser Seymour Kaplan, Lashkar Kashif, Valentin V. Khoze, Raman Khurana, Khristian Kotov, Dmytro Kovalskyi, Suchita Kulkarni, Shuichi Kunori, Viktor Kutzner, Hyun Min Lee, Sung-Won Lee, Seng Pei Liew, Tongyan Lin, Steven Lowette, Romain Madar, Sarah Malik, Fabio Maltoni, Mario Martinez Perez, Olivier Mattelaer, Kentarou Mawatari, Christopher McCabe, Théo Megy, Enrico Morgante, Stephen Mrenna, Chang-Seong Moon, Siddharth M. Narayanan, Andy Nelson, Sérgio F. Novaes, Klaas Ole Padeken, Priscilla Pani, Michele Papucci, Manfred Paulini, Christoph Paus, Jacopo Pazzini, Björn Penning, Michael E. Peskin, Deborah Pinna, Massimiliano Procura, Shamona F. Qazi, Davide Racco, Emanuele Re, Antonio Riotto, Thomas G. Rizzo, Rainer Roehrig, David Salek, Arturo Sanchez Pineda, Subir Sarkar, Alexander Schmidt, Steven Randolph Schramm, William Shepherd, Gurpreet Singh, Livia Soffi, Norraphat Srimanobhas, Kevin Sung, Tim M.P. Tait, Timothee Theveneaux-Pelzer, Marc Thomas, Mia Tosi, Daniele Trocino, Sonaina Undleeb, Alessandro Vichi, Fuquan Wang, Lian-Tao Wang, Ren-Jie Wang, Nikola Whallon, Steven Worm, Mengqing Wu, Sau Lan Wu, Hongtao Yang, Yong Yang, Shin-Shan Yu, Bryan Zaldivar, Marco Zanetti, Zhiqing Zhang, Alberto Zucchetta, Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre de Recherche Astrophysique de Lyon (CRAL), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire de Lyon (IPNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), Laboratoire de Physique de Clermont (LPC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Laboratoire de l'Accélérateur Linéaire (LAL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-École normale supérieure - Lyon (ENS Lyon), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Clermont Auvergne (UCA)-Centre National de la Recherche Scientifique (CNRS), Oviedo Univ, Louisville Univ, Duke Univ, CERN, Heidelberg Univ, Cornell Univ, INFN Padua, Boston Univ, Rutgers State Univ, NIKHEF, Paris LPTHE, Hyderabad Univ, UC Irvine, Munich MPI, MIT, INFN Rome, SISSA Trieste, LBL, Rhein Westfal TH Aachen, Princeton Univ, Delhi Univ, Florida Univ, Univ Maryland, Texas Tech Univ, Univ Geneva, CIEMAT, Univ Lyon, CNRS, Ecole Normale Super Lyon, Univ Montreal, TRIUMF, INFN Padova, Univ Wisconsin, Ohio State Univ, Rutherford Appleton Lab, Univ Southampton, Univ Melbourne, Imperial Coll London, SISSA, INFN, Univ Strasbourg, Univ Calif Santa Cruz, LIP Minho, Univ Porto, Univ Chicago, IFAE Barcelona, Univ Calif Berkeley, LBNL, Univ Zurich, Univ Lyon 1, Univ Calif Irvine, Dept Theoret Phys, Lund Univ, San Diego Univ, Louvain CP3, Osaka Univ, Kings Coll London, Freiburg Univ, DESY, Kyungpook Natl Univ, Vanderbilt Univ, Brandeis Univ, Perimeter, Annecy LAPTH, Mainz Univ, Univ Ghent, LPHE Lausanne, Univ Birmingham, Beijing IHEP, Shanghai Jiao Tong Univ, LAPTh, Zurich Univ, Univ Calif Davis, Tech Univ Dortmund, Univ Bristol, Fermilab Natl Accelerator Lab, Univ Grenoble Alpes, Austrian Acad Sci, Northwestern Univ, Univ Oxford, Univ Malaya, Harvard Univ, Univ Durham, Natl Cent Univ, Chung Ang Univ, Univ Tokyo, Vrije Univ Brussel IIHE, Lab Phys Corpusculaire, Catholic Univ Louvain, IPPP Durham, Vrije Univ Brussel, Int Solvay Inst, Univ Amsterdam, FNAL, Universidade Estadual Paulista (Unesp), Stockholm Univ, Carnegie Mellon Univ, Stanford Univ, Univ Wien, Quaid I Azam Univ, SLAC, Max Planck Inst Phys & Astrophys, Nikhef, GRAPPA, Univ Napoli, Niels Bohr Inst, Univ Hamburg, Santa Cruz Inst Particle Phys, Univ Copenhagen, Chulalongkorn Univ, Clermont Univ, Univ Blaise Pascal, Southampton Univ, Univ Padua, Northeastern Univ, Univ Washington, Univ Libre Bruxelles, Univ Paris Sud 11, Abercrombie D., Akchurin N., Akilli E., Maestre J.A., Allen B., Gonzalez B.A., Andrea J., Arbey A., Azuelos G., Azzi P., Backovic M., Bai Y., Banerjee S., Beacham J., Belyaev A., Boveia A., Brennan A.J., Buchmueller O., Buckley M.R., Busoni G., Buttignol M., Cacciapaglia G., Caputo R., Carpenter L., Castro N.F., Ceballos G.G., Cheng Y., Chou J.P., Gonzalez A.C., Cowden C., D'Eramo F., De Cosa A., De Gruttola M., De Roeck A., De Simone A., Deandrea A., Demiragli Z., DiFranzo A., Doglioni C., du Pree T., Erbacher R., Erdmann J., Fischer C., Flaecher H., Fox P.J., Fuks B., Genest M.-H., Gomber B., Goudelis A., Gramling J., Gunion J., Hahn K., Haisch U., Harnik R., Harris P.C., Hoepfner K., Hoh S.Y., Hsu D.G., Hsu S.-C., Iiyama Y., Ippolito V., Jacques T., Ju X., Kahlhoefer F., Kalogeropoulos A., Kaplan L.S., Kashif L., Khoze V.V., Khurana R., Kotov K., Kovalskyi D., Kulkarni S., Kunori S., Kutzner V., Lee H.M., Lee S.-W., Liew S.P., Lin T., Lowette S., Madar R., Malik S., Maltoni F., Perez M.M., Mattelaer O., Mawatari K., McCabe C., Megy T., Morgante E., Mrenna S., Moon C.-S., Narayanan S.M., Nelson A., Novaes S.F., Padeken K.O., Pani P., Papucci M., Paulini M., Paus C., Pazzini J., Penning B., Peskin M.E., Pinna D., Procura M., Qazi S.F., Racco D., Re E., Riotto A., Rizzo T.G., Roehrig R., Salek D., Pineda A.S., Sarkar S., Schmidt A., Schramm S.R., Shepherd W., Singh G., Soffi L., Srimanobhas N., Sung K., Tait T.M.P., Theveneaux-Pelzer T., Thomas M., Tosi M., Trocino D., Undleeb S., Vichi A., Wang F., Wang L.-T., Wang R.-J., Whallon N., Worm S., Wu M., Wu S.L., Yang H., Yang Y., Yu S.-S., Zaldivar B., Zanetti M., Zhang Z., Zucchetta A., Physics, Elementary Particle Physics, Universidade do Minho, GRAPPA (ITFA, IoP, FNWI), ATLAS (IHEF, IoP, FNWI), Daniel, A, Nural, A, Ece, A, Juan Alcaraz, M, Brandon, A, Barbara Alvarez, G, Jeremy, A, Alexandre, A, Georges, A, Patrizia, A, Mihailo, B, Yang, B, Swagato, B, James, B, Alexander, B, Antonio, B, Amelia Jean, B, Oliver, B, Matthew R., B, Giorgio, B, Michael, B, Giacomo, C, Regina, C, Linda, C, Nuno Filipe, C, Guillelmo Gomez, C, Yangyang, C, John Paul, C, Arely Cortes, G, Chris, C, Francesco, D, Annapaola De, C, Michele De, G, Albert De, R, Andrea De, S, Aldo, D, Zeynep, D, Anthony, D, Caterina, D, Tristan du PreeRobin, E, Johannes, E, Cora, F, Henning, F, Patrick J., F, Benjamin, F, Marie-Helene, G, Bhawna, G, Andreas, G, Johanna, G, John, G, Kristian, H, Ulrich, H, Roni, H, Philip C., H, Kerstin, H, Siew Yan, H, Dylan George, H, Shih-Chieh, H, Yutaro, I, Valerio, I, Thomas, J, Xiangyang, J, Felix, K, Alexis, K, Laser Seymour, K, Lashkar, K, Valentin V., K, Raman, K, Khristian, K, Dmytro, K, Suchita, K, Shuichi, K, Viktor, K, Hyun Min, L, Sung-Won, L, Seng Pei, L, Tongyan, L, Steven, L, Romain, M, Sarah, M, Fabio, M, Mario Martinez, P, Olivier, M, Kentarou, M, Christopher, M, Théo, M, Enrico, M, Stephen, M, Siddharth M., N, Andy, N, Sérgio F., N, Klaas Ole, P, Priscilla, P, Michele, P, Manfred, P, Christoph, P, Jacopo, P, Björn, P, Michael E., P, Deborah, P, Massimiliano, P, Shamona F., Q, Davide, R, Re, E, Antonio, R, Thomas G., R, Rainer, R, David, S, Arturo Sanchez, P, Subir, S, Alexander, S, Steven Randolph, S, William, S, Gurpreet, S, Livia, S, Norraphat, S, Kevin, S, Tim M. P., T, Timothee, T, Marc, T, Mia, T, Daniele, T, Sonaina, U, Alessandro, V, Fuquan, W, Lian-Tao, W, Ren-Jie, W, Nikola, W, Steven, W, Mengqing, W, Sau Lan, W, Hongtao, Y, Yong, Y, Shin-Shan, Y, Bryan, Z, Marco, Z, Zhiqing, Z, Alberto, Z, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), and Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11)

Subjects
dark matter: interaction, Simplified model, Physics::Instrumentation and Detectors, mass [dark matter], Parameter space, 01 natural sciences, High Energy Physics - Experiment, dark matter: coupling, High Energy Physics - Experiment (hep-ex), High Energy Physics - Phenomenology (hep-ph), benchmark, effective field theory, search for [dark matter], scattering [p p], Effective field theory, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], Dark Matter, Simplified models, 010303 astronomy & astrophysics, Physics, Large Hadron Collider, Atlas (topology), CMS, hep-ph, ATLAS, Settore FIS/02 - Fisica Teorica, Modelli e Metodi Matematici, High Energy Physics - Phenomenology, CERN LHC Coll, interpretation of experiments, LHC, colliding beams [p p], interaction [dark matter], EFT, Particle Physics - Experiment, Particle physics, p p: scattering, Ciências Naturais::Ciências Físicas, WIMP, dark matter: search for, Ciências Físicas [Ciências Naturais], Dark matter, FOS: Physical sciences, dark matter: production, coupling [dark matter], 0103 physical sciences, ddc:530, mediation, ComputingMethodologies_COMPUTERGRAPHICS, Particle Physics - Phenomenology, Science & Technology, 010308 nuclear & particles physics, hep-ex, dark matter: mass, Astronomy and Astrophysics, production [dark matter], Formalism (philosophy of mathematics), Space and Planetary Science, [PHYS.HPHE]Physics [physics]/High Energy Physics - Phenomenology [hep-ph], direct detection, p p: colliding beams
Abstract

This document is the final report of the ATLAS-CMS Dark Matter Forum, a forum organized by the ATLAS and CMS collaborations with the participation of experts on theories of Dark Matter, to select a minimal basis set of dark matter simplified models that should support the design of the early LHC Run-2 searches. A prioritized, compact set of benchmark models is proposed, accompanied by studies of the parameter space of these models and a repository of generator implementations. This report also addresses how to apply the Effective Field Theory formalism for collider searches and present the results of such interpretations., The authors would like to thank Daniel Whiteson for helping in the review of this document. This research was supported by the Munich Institute for Astro- and Particle Physics (MIAPP) of the DFG cluster of excellence "Origin and Structure of the Universe''. The authors would like to express a special thanks to the Mainz Institute for Theoretical Physics (MITP) for its hospitality and support. P. Pani wishes to thank the support of the Computing Infrastructure of Nikhef. In addition we thank CERN and acknowledge the support of: DOE and NSF (USA), including grant DE-SC0011726 for the preparation of this manuscript; SER, SNSF and Cantons of Bern and Geneva, Switzerland; MINECO, Spain; European Union, where the preparation of this manuscript is part of a project that has received funding from the European Research Council under the European Union's Horizon 2020 research and innovation program (grant agreement 679305); IN2P3-CNRS, CEA-DSM/IRFU, France; NSERC, NRC, and CFI, Canada; INFN, Italy; FNRS and FWO, Belgium; STFC, United Kingdom; ARC, Australia; GRICES and FCT, Portugal; SRC, Sweden; BMBF, DFG, HGF, MPG and AvH Foundation, Germany; Austrian Academy of Sciences, Austria; MOE and UM, Malaysia; National Research Foundation and Ministry of Education, Science and Technology, Korea; MEXT and JSPS, Japan; FOM and NWO, Netherlands; CNPq and FAPESP, Brazil; Atomic Energy Commission, Pakistan; DNRF, DNSRC and Lundbeck Foundation, Denmark; Thailand Center of Excellence in Physics, Institute for the Promotion of Teaching Science and Technology, Special Task Force for Activating Research and National Science and Technology Development Agency, Thailand; MOST, Taiwan., info:eu-repo/semantics/publishedVersion

Published
2015
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16. Fractionation of hexane extracts from Achyrocline satureioides and their biological activities against Paenibacillus larvae.

Author

Tonello N, Pimentel Betancurt D, Huallpa CL, Marioli JM, Moressi MB, Oliva MLM, and D'Eramo F

Subjects
Animals, Bees, Hexanes pharmacology, Larva microbiology, Microbial Sensitivity Tests, United States, Achyrocline chemistry, Anti-Infective Agents pharmacology, Paenibacillus, Paenibacillus larvae
Abstract

Previous studies carried out in our laboratory described the antimicrobial activity of the whole hexanic extract (HE) of Achyrocline satureioides (Lam.) DC against Paenibacillus larvae, the causal agent of American Foulbrood (AFB) a disease of the honey bee larvae. In this study, the HE was partitioned into five main fractions by chromatographic techniques leading to the isolation of four known compounds: two prenylated phloroglucinol α-pyrones (1 and 3), 5,7-dihydroxy-3,8-dimethoxyflavone (gnaphaliin A) (2), and 23-methyl-6-O-demethylauricepyrone (4). Isolated compounds were further analyzed towards structural elucidation using 1 H RMN and 13 C RMN spectroscopic techniques. For the first time, the antimicrobial activity of the isolated compounds was evaluated against P. larvae strains by broth microdilution method and compared with that of the whole HE. Compounds 1-4 displayed minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values ranging between 0.07 and 62.5 μg/mL and 0.26 and 12.5 μg/mL, respectively. The lowest MIC and MBC values were obtained with compounds 3 and 4, respectively. The antimicrobial activity of each single compound and the combination of them showed that the presence of all compounds is needed for the antimicrobial efficacy of whole HE., (© 2022. The Author(s) under exclusive licence to Sociedade Brasileira de Microbiologia.)

Published
2022
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17. Immunotherapeutic HCW9218 augments anti-tumor activity of chemotherapy via NK cell-mediated reduction of therapy-induced senescent cells.

Author

Chaturvedi P, George V, Shrestha N, Wang M, Dee MJ, Zhu X, Liu B, Egan J, D'Eramo F, Spanoudis C, Gallo V, Echeverri C, You L, Kong L, Fang B, Jeng EK, Rhode PR, and Wong HC

Subjects
Animals, Cell Line, Tumor, Cellular Senescence, Docetaxel metabolism, Docetaxel pharmacology, Immunotherapy methods, Mice, Tumor Microenvironment, B7-H1 Antigen metabolism, Killer Cells, Natural metabolism
Abstract

Therapy induced senescence (TIS) in tumors and TIS cancer cells secrete proinflammatory senescence-associated secretory phenotype (SASP) factors. SASP factors promote TIS cancer cells to re-enter the growth cycle with stemness characteristics, resulting in chemo-resistance and disease relapse. Herein, we show that the immunotherapeutic HCW9218, comprising transforming growth factor-β (TGF-β) receptor II and interleukin (IL)-15/IL-15 receptor α domains, enhances metabolic and cytotoxic activities of immune cells and reduces TIS tumor cells in vivo to improve the efficacy of docetaxel and gemcitabine plus nab-paclitaxel against B16F10 melanoma and SW1990 pancreatic tumors, respectively. Mechanistically, HCW9218 treatment reduces the immunosuppressive tumor microenvironment and enhances immune cell infiltration and cytotoxicity in the tumors to eliminate TIS cancer cells. Immuno-depletion analysis suggests that HCW9218-activated natural killer cells play a pivotal role in TIS cancer cell removal. HCW9218 treatment following docetaxel chemotherapy further enhances efficacy of tumor antigen-specific and anti-programmed death-ligand 1 (PD-L1) antibodies in B16F10 tumor-bearing mice. We also show that HCW9218 treatment decreases TIS cells and lowers SASP factors in off-target tissues caused by chemotherapy of tumor-bearing mice. Collectively, HCW9218 has the potential to significantly enhance anti-tumor efficacy of chemotherapy, therapeutic antibodies, and checkpoint blockade by eliminating TIS cancer cells while reducing TIS-mediated proinflammatory side effects in normal tissues., Competing Interests: Declaration of interests At the time the study was conducted, all of the authors were employees of HCW Biologics, the sponsor of the study., (Copyright © 2022 The American Society of Gene and Cell Therapy. Published by Elsevier Inc. All rights reserved.)

Published
2022
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18. Tumor-targeted silencing of the peptide transporter TAP induces potent antitumor immunity.

Author

Garrido G, Schrand B, Rabasa A, Levay A, D'Eramo F, Berezhnoy A, Modi S, Gefen T, Marijt K, Doorduijn E, Dudeja V, van Hall T, and Gilboa E

Subjects
ATP-Binding Cassette Transporters genetics, Animals, Antigens, Neoplasm genetics, Aptamers, Nucleotide, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Cancer Vaccines, Cell Line, Tumor, Down-Regulation, Epitopes immunology, Female, Humans, Immunization, Immunogenicity, Vaccine, Male, Membrane Proteins immunology, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Molecular Targeted Therapy, NIH 3T3 Cells, Neoplasms, Experimental, Oligodeoxyribonucleotides, Phosphoproteins, Programmed Cell Death 1 Receptor immunology, RNA, Small Interfering administration & dosage, RNA-Binding Proteins, Spleen immunology, Spleen pathology, Vaccination, Nucleolin, ATP-Binding Cassette Transporters immunology, Antigens, Neoplasm immunology, Immunotherapy, Neoplasms immunology, Neoplasms prevention & control
Abstract

Neoantigen burden is a major determinant of tumor immunogenicity, underscored by recent clinical experience with checkpoint blockade therapy. Yet the majority of patients do not express, or express too few, neoantigens, and hence are less responsive to immune therapy. Here we describe an approach whereby a common set of new antigens are induced in tumor cells in situ by transient downregulation of the transporter associated with antigen processing (TAP). Administration of TAP siRNA conjugated to a broad-range tumor-targeting nucleolin aptamer inhibited tumor growth in multiple tumor models without measurable toxicity, was comparatively effective to vaccination against prototypic mutation-generated neoantigens, potentiated the antitumor effect of PD-1 antibody or Flt3 ligand, and induced the presentation of a TAP-independent peptide in human tumor cells. Treatment with the chemically-synthesized nucleolin aptamer-TAP siRNA conjugate represents a broadly-applicable approach to increase the antigenicity of tumor lesions and thereby enhance the effectiveness of immune potentiating therapies.

Published
2019
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