554 results on '"Dahl, Andreas"'
Search Results
2. Resistance of HNSCC cell models to pan-FGFR inhibition depends on the EMT phenotype associating with clinical outcome
- Author
-
Broghammer, Felix, Korovina, Irina, Gouda, Mahesh, Celotti, Martina, van Es, Johan, Lange, Inga, Brunner, Cornelia, Mircetic, Jovan, Coppes, Robert P., Gires, Olivier, Dahl, Andreas, Seifert, Michael, and Cordes, Nils
- Published
- 2024
- Full Text
- View/download PDF
3. Large-scale analysis of structural brain asymmetries in schizophrenia via the ENIGMA consortium.
- Author
-
Schijven, Dick, Postema, Merel C, Fukunaga, Masaki, Matsumoto, Junya, Miura, Kenichiro, de Zwarte, Sonja MC, van Haren, Neeltje EM, Cahn, Wiepke, Hulshoff Pol, Hilleke E, Kahn, René S, Ayesa-Arriola, Rosa, Ortiz-García de la Foz, Víctor, Tordesillas-Gutierrez, Diana, Vázquez-Bourgon, Javier, Crespo-Facorro, Benedicto, Alnæs, Dag, Dahl, Andreas, Westlye, Lars T, Agartz, Ingrid, Andreassen, Ole A, Jönsson, Erik G, Kochunov, Peter, Bruggemann, Jason M, Catts, Stanley V, Michie, Patricia T, Mowry, Bryan J, Quidé, Yann, Rasser, Paul E, Schall, Ulrich, Scott, Rodney J, Carr, Vaughan J, Green, Melissa J, Henskens, Frans A, Loughland, Carmel M, Pantelis, Christos, Weickert, Cynthia Shannon, Weickert, Thomas W, de Haan, Lieuwe, Brosch, Katharina, Pfarr, Julia-Katharina, Ringwald, Kai G, Stein, Frederike, Jansen, Andreas, Kircher, Tilo TJ, Nenadić, Igor, Krämer, Bernd, Gruber, Oliver, Satterthwaite, Theodore D, Bustillo, Juan, Mathalon, Daniel H, Preda, Adrian, Calhoun, Vince D, Ford, Judith M, Potkin, Steven G, Chen, Jingxu, Tan, Yunlong, Wang, Zhiren, Xiang, Hong, Fan, Fengmei, Bernardoni, Fabio, Ehrlich, Stefan, Fuentes-Claramonte, Paola, Garcia-Leon, Maria Angeles, Guerrero-Pedraza, Amalia, Salvador, Raymond, Sarró, Salvador, Pomarol-Clotet, Edith, Ciullo, Valentina, Piras, Fabrizio, Vecchio, Daniela, Banaj, Nerisa, Spalletta, Gianfranco, Michielse, Stijn, van Amelsvoort, Therese, Dickie, Erin W, Voineskos, Aristotle N, Sim, Kang, Ciufolini, Simone, Dazzan, Paola, Murray, Robin M, Kim, Woo-Sung, Chung, Young-Chul, Andreou, Christina, Schmidt, André, Borgwardt, Stefan, McIntosh, Andrew M, Whalley, Heather C, Lawrie, Stephen M, du Plessis, Stefan, Luckhoff, Hilmar K, Scheffler, Freda, Emsley, Robin, Grotegerd, Dominik, Lencer, Rebekka, Dannlowski, Udo, Edmond, Jesse T, Rootes-Murdy, Kelly, Stephen, Julia M, Mayer, Andrew R, and Antonucci, Linda A
- Subjects
Brain ,Cerebral Cortex ,Humans ,Magnetic Resonance Imaging ,Case-Control Studies ,Schizophrenia ,Female ,Male ,Functional Laterality ,asymmetry ,brain imaging ,cortical ,subcortical ,Clinical Research ,Mental Health ,Neurosciences ,Brain Disorders ,Mental health - Abstract
Left-right asymmetry is an important organizing feature of the healthy brain that may be altered in schizophrenia, but most studies have used relatively small samples and heterogeneous approaches, resulting in equivocal findings. We carried out the largest case-control study of structural brain asymmetries in schizophrenia, with MRI data from 5,080 affected individuals and 6,015 controls across 46 datasets, using a single image analysis protocol. Asymmetry indexes were calculated for global and regional cortical thickness, surface area, and subcortical volume measures. Differences of asymmetry were calculated between affected individuals and controls per dataset, and effect sizes were meta-analyzed across datasets. Small average case-control differences were observed for thickness asymmetries of the rostral anterior cingulate and the middle temporal gyrus, both driven by thinner left-hemispheric cortices in schizophrenia. Analyses of these asymmetries with respect to the use of antipsychotic medication and other clinical variables did not show any significant associations. Assessment of age- and sex-specific effects revealed a stronger average leftward asymmetry of pallidum volume between older cases and controls. Case-control differences in a multivariate context were assessed in a subset of the data (N = 2,029), which revealed that 7% of the variance across all structural asymmetries was explained by case-control status. Subtle case-control differences of brain macrostructural asymmetry may reflect differences at the molecular, cytoarchitectonic, or circuit levels that have functional relevance for the disorder. Reduced left middle temporal cortical thickness is consistent with altered left-hemisphere language network organization in schizophrenia.
- Published
- 2023
4. Virtual Ontogeny of Cortical Growth Preceding Mental Illness
- Author
-
Patel, Yash, Shin, Jean, Abé, Christoph, Agartz, Ingrid, Alloza, Clara, Alnæs, Dag, Ambrogi, Sonia, Antonucci, Linda A, Arango, Celso, Arolt, Volker, Auzias, Guillaume, Ayesa-Arriola, Rosa, Banaj, Nerisa, Banaschewski, Tobias, Bandeira, Cibele, Başgöze, Zeynep, Cupertino, Renata Basso, Bau, Claiton HD, Bauer, Jochen, Baumeister, Sarah, Bernardoni, Fabio, Bertolino, Alessandro, Bonnin, Caterina Del Mar, Brandeis, Daniel, Brem, Silvia, Bruggemann, Jason, Bülow, Robin, Bustillo, Juan R, Calderoni, Sara, Calvo, Rosa, Canales-Rodríguez, Erick J, Cannon, Dara M, Carmona, Susanna, Carr, Vaughan J, Catts, Stanley V, Chenji, Sneha, Chew, Qian Hui, Coghill, David, Connolly, Colm G, Conzelmann, Annette, Craven, Alexander R, Crespo-Facorro, Benedicto, Cullen, Kathryn, Dahl, Andreas, Dannlowski, Udo, Davey, Christopher G, Deruelle, Christine, Díaz-Caneja, Covadonga M, Dohm, Katharina, Ehrlich, Stefan, Epstein, Jeffery, Erwin-Grabner, Tracy, Eyler, Lisa T, Fedor, Jennifer, Fitzgerald, Jacqueline, Foran, William, Ford, Judith M, Fortea, Lydia, Fuentes-Claramonte, Paola, Fullerton, Janice, Furlong, Lisa, Gallagher, Louise, Gao, Bingchen, Gao, Si, Goikolea, Jose M, Gotlib, Ian, Goya-Maldonado, Roberto, Grabe, Hans J, Green, Melissa, Grevet, Eugenio H, Groenewold, Nynke A, Grotegerd, Dominik, Gruber, Oliver, Haavik, Jan, Hahn, Tim, Harrison, Ben J, Heindel, Walter, Henskens, Frans, Heslenfeld, Dirk J, Hilland, Eva, Hoekstra, Pieter J, Hohmann, Sarah, Holz, Nathalie, Howells, Fleur M, Ipser, Jonathan C, Jahanshad, Neda, Jakobi, Babette, Jansen, Andreas, Janssen, Joost, Jonassen, Rune, Kaiser, Anna, Kaleda, Vasiliy, Karantonis, James, King, Joseph A, Kircher, Tilo, Kochunov, Peter, Koopowitz, Sheri-Michelle, Landén, Mikael, Landrø, Nils Inge, and Lawrie, Stephen
- Subjects
Biological Psychology ,Biomedical and Clinical Sciences ,Psychology ,Neurosciences ,Genetics ,Mental Health ,Serious Mental Illness ,Mental Illness ,Women's Health ,Brain Disorders ,Preterm ,Low Birth Weight and Health of the Newborn ,Pregnancy ,Pediatric ,Perinatal Period - Conditions Originating in Perinatal Period ,Behavioral and Social Science ,Prevention ,Schizophrenia ,2.1 Biological and endogenous factors ,2.3 Psychological ,social and economic factors ,Neurological ,Reproductive health and childbirth ,Mental health ,Good Health and Well Being ,Attention Deficit Disorder with Hyperactivity ,Autism Spectrum Disorder ,Bipolar Disorder ,Cerebral Cortex ,Child ,Depressive Disorder ,Major ,Female ,Humans ,Infant ,Newborn ,Magnetic Resonance Imaging ,Premature Birth ,Cortical growth ,Cortical surface area ,Mental illness ,Neurodevelopment ,Neurogenesis ,Psychiatric disorders ,Biological Sciences ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Psychiatry ,Biological sciences ,Biomedical and clinical sciences - Abstract
BackgroundMorphology of the human cerebral cortex differs across psychiatric disorders, with neurobiology and developmental origins mostly undetermined. Deviations in the tangential growth of the cerebral cortex during pre/perinatal periods may be reflected in individual variations in cortical surface area later in life.MethodsInterregional profiles of group differences in surface area between cases and controls were generated using T1-weighted magnetic resonance imaging from 27,359 individuals including those with attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depressive disorder, schizophrenia, and high general psychopathology (through the Child Behavior Checklist). Similarity of interregional profiles of group differences in surface area and prenatal cell-specific gene expression was assessed.ResultsAcross the 11 cortical regions, group differences in cortical area for attention-deficit/hyperactivity disorder, schizophrenia, and Child Behavior Checklist were dominant in multimodal association cortices. The same interregional profiles were also associated with interregional profiles of (prenatal) gene expression specific to proliferative cells, namely radial glia and intermediate progenitor cells (greater expression, larger difference), as well as differentiated cells, namely excitatory neurons and endothelial and mural cells (greater expression, smaller difference). Finally, these cell types were implicated in known pre/perinatal risk factors for psychosis. Genes coexpressed with radial glia were enriched with genes implicated in congenital abnormalities, birth weight, hypoxia, and starvation. Genes coexpressed with endothelial and mural genes were enriched with genes associated with maternal hypertension and preterm birth.ConclusionsOur findings support a neurodevelopmental model of vulnerability to mental illness whereby prenatal risk factors acting through cell-specific processes lead to deviations from typical brain development during pregnancy.
- Published
- 2022
5. Compartmentalization and synergy of osteoblasts drive bone formation in the regenerating fin
- Author
-
Cudak, Nicole, López-Delgado, Alejandra Cristina, Rost, Fabian, Kurth, Thomas, Lesche, Mathias, Reinhardt, Susanne, Dahl, Andreas, Rulands, Steffen, and Knopf, Franziska
- Published
- 2024
- Full Text
- View/download PDF
6. Genetic and brain similarity independently predict childhood anthropometrics and neighborhood socioeconomic conditions
- Author
-
Dahl, Andreas, Eilertsen, Espen M., Rodriguez-Cabello, Sara F., Norbom, Linn B., Tandberg, Anneli D., Leonardsen, Esten, Lee, Sang Hong, Ystrom, Eivind, Tamnes, Christian K., Alnæs, Dag, and Westlye, Lars T.
- Published
- 2024
- Full Text
- View/download PDF
7. Linking brain maturation and puberty during early adolescence using longitudinal brain age prediction in the ABCD cohort
- Author
-
Holm, Madelene C., Leonardsen, Esten H., Beck, Dani, Dahl, Andreas, Kjelkenes, Rikka, de Lange, Ann-Marie G., and Westlye, Lars T.
- Published
- 2023
- Full Text
- View/download PDF
8. Mapping Normative Trajectories of Cognitive Function and Its Relation to Psychopathology Symptoms and Genetic Risk in Youth
- Author
-
Kjelkenes, Rikka, Wolfers, Thomas, Alnæs, Dag, van der Meer, Dennis, Pedersen, Mads Lund, Dahl, Andreas, Voldsbekk, Irene, Moberget, Torgeir, Tamnes, Christian K., Andreassen, Ole A., Marquand, Andre F., and Westlye, Lars T.
- Published
- 2023
- Full Text
- View/download PDF
9. Delineating disorder-general and disorder-specific dimensions of psychopathology from functional brain networks in a developmental clinical sample
- Author
-
Voldsbekk, Irene, Kjelkenes, Rikka, Dahl, Andreas, Holm, Madelene C., Lund, Martina J., Kaufmann, Tobias, Tamnes, Christian K., Andreassen, Ole A., Westlye, Lars T., and Alnæs, Dag
- Published
- 2023
- Full Text
- View/download PDF
10. Deviations from normative brain white and gray matter structure are associated with psychopathology in youth
- Author
-
Kjelkenes, Rikka, Wolfers, Thomas, Alnæs, Dag, Norbom, Linn B., Voldsbekk, Irene, Holm, Madelene, Dahl, Andreas, Berthet, Pierre, Tamnes, Christian K., Marquand, Andre F., and Westlye, Lars T.
- Published
- 2022
- Full Text
- View/download PDF
11. Associations between brain imaging and polygenic scores of mental health and educational attainment in children aged 9–11
- Author
-
Fernandez-Cabello, Sara, Alnæs, Dag, van der Meer, Dennis, Dahl, Andreas, Holm, Madelene, Kjelkenes, Rikka, Maximov, Ivan I., Norbom, Linn B., Pedersen, Mads L., Voldsbekk, Irene, Andreassen, Ole A., and Westlye, Lars T.
- Published
- 2022
- Full Text
- View/download PDF
12. Tissue dissociation for single-cell and single-nuclei RNA sequencing for low amounts of input material
- Author
-
Wiegleb, Gordon, Reinhardt, Susanne, Dahl, Andreas, and Posnien, Nico
- Published
- 2022
- Full Text
- View/download PDF
13. Fate mapping of hematopoietic stem cells reveals two pathways of native thrombopoiesis
- Author
-
Morcos, Mina N. F., Li, Congxin, Munz, Clara M., Greco, Alessandro, Dressel, Nicole, Reinhardt, Susanne, Sameith, Katrin, Dahl, Andreas, Becker, Nils B., Roers, Axel, Höfer, Thomas, and Gerbaulet, Alexander
- Published
- 2022
- Full Text
- View/download PDF
14. CDK7 inhibition augments response to multidrug chemotherapy in pancreatic cancer
- Author
-
Zeng, Siyuan, Lan, Bin, Ren, Xiaofan, Zhang, Shuman, Schreyer, Daniel, Eckstein, Markus, Yang, Hai, Britzen-Laurent, Nathalie, Dahl, Andreas, Mukhopadhyay, Debabrata, Chang, David, Kutschick, Isabella, Pfeffer, Susanne, Bailey, Peter, Biankin, Andrew, Grützmann, Robert, and Pilarsky, Christian
- Published
- 2022
- Full Text
- View/download PDF
15. Targeting cardiomyocyte ADAM10 ectodomain shedding promotes survival early after myocardial infarction
- Author
-
Klapproth, Erik, Witt, Anke, Klose, Pauline, Wiedemann, Johanna, Vavilthota, Nikitha, Künzel, Stephan R., Kämmerer, Susanne, Günscht, Mario, Sprott, David, Lesche, Mathias, Rost, Fabian, Dahl, Andreas, Rauch, Erik, Kattner, Lars, Weber, Silvio, Mirtschink, Peter, Kopaliani, Irakli, Guan, Kaomei, Lorenz, Kristina, Saftig, Paul, Wagner, Michael, and El-Armouche, Ali
- Published
- 2022
- Full Text
- View/download PDF
16. CD38 promotes hematopoietic stem cell dormancy
- Author
-
Ibneeva, Liliia, primary, Singh, Sumeet Pal, additional, Sinha, Anupam, additional, Eski, Sema Elif, additional, Wehner, Rebekka, additional, Rupp, Luise, additional, Kovtun, Iryna, additional, Pérez-Valencia, Juan Alberto, additional, Gerbaulet, Alexander, additional, Reinhardt, Susanne, additional, Wobus, Manja, additional, von Bonin, Malte, additional, Sancho, Jaime, additional, Lund, Frances, additional, Dahl, Andreas, additional, Schmitz, Marc, additional, Bornhäuser, Martin, additional, Chavakis, Triantafyllos, additional, Wielockx, Ben, additional, and Grinenko, Tatyana, additional
- Published
- 2024
- Full Text
- View/download PDF
17. Parental education and income are linked to offspring cortical brain structure and psychopathology at 9–11 years
- Author
-
Norbom, Linn B., primary, Rokicki, Jaroslav, additional, Eilertsen, Espen M., additional, Wiker, Thea, additional, Hanson, Jamie, additional, Dahl, Andreas, additional, Alnæs, Dag, additional, Fernández‐Cabello, Sara, additional, Beck, Dani, additional, Agartz, Ingrid, additional, Andreassen, Ole A., additional, Westlye, Lars T., additional, and Tamnes, Christian K., additional
- Published
- 2024
- Full Text
- View/download PDF
18. Low Threshold for Cutaneous Allergen Sensitization but No Spontaneous Dermatitis or Atopy in FLG-Deficient Mice
- Author
-
Muhandes, Lina, Chapsa, Maria, Pippel, Martin, Behrendt, Rayk, Ge, Yan, Dahl, Andreas, Yi, Buqing, Dalpke, Alexander, Winkler, Sylke, Hiller, Michael, Boutin, Sebastien, Beissert, Stefan, Jessberger, Rolf, Fallon, Padraic G., and Roers, Axel
- Published
- 2021
- Full Text
- View/download PDF
19. The hepatokine fetuin-A disrupts functional maturation of pancreatic beta cells
- Author
-
Gerst, Felicia, Kemter, Elisabeth, Lorza-Gil, Estela, Kaiser, Gabriele, Fritz, Ann-Kathrin, Nano, Rita, Piemonti, Lorenzo, Gauder, Marie, Dahl, Andreas, Nadalin, Silvio, Königsrainer, Alfred, Fend, Falko, Birkenfeld, Andreas L., Wagner, Robert, Heni, Martin, Stefan, Norbert, Wolf, Eckhard, Häring, Hans-Ulrich, and Ullrich, Susanne
- Published
- 2021
- Full Text
- View/download PDF
20. CD38 promotes hematopoietic stem cell dormancy
- Author
-
Ibneeva, Liliia, Singh, Sumeet Pal, Sinha, Anupam, Eski, Sema Elif, Wehner, Rebekka, Rupp, Luise, Kovtun, Iryna, Pérez-Valencia, Juan Alberto, Gerbaulet, Alexander, Reinhardt, Susanne, Wobus, Manja, von Bonin, Malte, Sancho, Jaime, Lund, Frances, Dahl, Andreas, Schmitz, Marc, Bornhäuser, Martin, Chavakis, Triantafyllos, Wielockx, Ben, Grinenko, Tatyana, Ibneeva, Liliia, Singh, Sumeet Pal, Sinha, Anupam, Eski, Sema Elif, Wehner, Rebekka, Rupp, Luise, Kovtun, Iryna, Pérez-Valencia, Juan Alberto, Gerbaulet, Alexander, Reinhardt, Susanne, Wobus, Manja, von Bonin, Malte, Sancho, Jaime, Lund, Frances, Dahl, Andreas, Schmitz, Marc, Bornhäuser, Martin, Chavakis, Triantafyllos, Wielockx, Ben, and Grinenko, Tatyana
- Abstract
AU A subpopulation: Pleaseconfirmthatallheadinglevelsarerepresentedcorrectly of deeply quiescent, so-called dormant hematopoietic :stem cells (dHSCs) resides at the top of the hematopoietic hierarchy and serves as a reserve pool for HSCs. The state of dormancy protects the HSC pool from exhaustion throughout life; however, excessive dormancy may prevent an efficient response to hematological stresses. Despite the significance of dHSCs, the mechanisms maintaining their dormancy remain elusive. Here, we identify CD38 as a novel and broadly applicable surface marker for the enrichment of murine dHSCs. We demonstrate that cyclic adenosine diphosphate ribose (cADPR), the product of CD38 cyclase activity, regulates the expression of the transcription factor c-Fos by increasing the release of Ca2+ from the endoplasmic reticulum (ER). Subsequently, we uncover that c-Fos induces the expression of the cell cycle inhibitor p57Kip2 to drive HSC dormancy. Moreover, we found that CD38 ecto-enzymatic activity at the neighboring CD38-positive cells can promote human HSC quiescence. Together, CD38/cADPR/Ca2+/c-Fos/ p57Kip2 axis maintains HSC dormancy. Pharmacological manipulations of this pathway can provide new strategies to improve the success of stem cell transplantation and blood regeneration after injury or disease., SCOPUS: ar.j, info:eu-repo/semantics/published
- Published
- 2024
21. Exome sequencing identifies frequent genomic loss of TET1 in IDH-wild-type glioblastoma
- Author
-
Stasik, Sebastian, Juratli, Tareq A., Petzold, Andreas, Richter, Sven, Zolal, Amir, Schackert, Gabriele, Dahl, Andreas, Krex, Dietmar, and Thiede, Christian
- Published
- 2020
- Full Text
- View/download PDF
22. Single-cell RNA sequencing unravels the transcriptional network underlying zebrafish retina regeneration
- Author
-
Celotto, Laura, primary, Rost, Fabian, additional, Machate, Anja, additional, Bläsche, Juliane, additional, Dahl, Andreas, additional, Weber, Anke, additional, Hans, Stefan, additional, and Brand, Michael, additional
- Published
- 2023
- Full Text
- View/download PDF
23. Aldh1b1 expression defines progenitor cells in the adult pancreas and is required for Kras-induced pancreatic cancer
- Author
-
Mameishvili, Ekaterina, Serafimidis, Ioannis, Iwaszkiewicz, Sara, Lesche, Mathias, Reinhardt, Susanne, Bölicke, Nora, Büttner, Maren, Stellas, Dimitris, Papadimitropoulou, Adriana, Szabolcs, Matthias, Anastassiadis, Konstantinos, Dahl, Andreas, Theis, Fabian, Efstratiadis, Argiris, and Gavalas, Anthony
- Published
- 2019
24. Transcriptional profile of AvrRpt2EA-mediated resistance and susceptibility response to Erwinia amylovora in apple
- Author
-
Schröpfer, Susan, Vogt, Isabelle, Broggini, Giovanni Antonio Lodovico, Dahl, Andreas, Richter, Klaus, Hanke, Magda-Viola, Flachowsky, Henryk, and Peil, Andreas
- Published
- 2021
- Full Text
- View/download PDF
25. Environmental enrichment preserves a young DNA methylation landscape in the aged mouse hippocampus
- Author
-
Zocher, Sara, Overall, Rupert W., Lesche, Mathias, Dahl, Andreas, and Kempermann, Gerd
- Published
- 2021
- Full Text
- View/download PDF
26. Cre-Controlled CRISPR mutagenesis provides fast and easy conditional gene inactivation in zebrafish
- Author
-
Hans, Stefan, Zöller, Daniela, Hammer, Juliane, Stucke, Johanna, Spieß, Sandra, Kesavan, Gokul, Kroehne, Volker, Eguiguren, Juan Sebastian, Ezhkova, Diana, Petzold, Andreas, Dahl, Andreas, and Brand, Michael
- Published
- 2021
- Full Text
- View/download PDF
27. Prospective isolation of nonhematopoietic cells of the niche and their differential molecular interactions with HSCs
- Author
-
Mende, Nicole, Jolly, Adrien, Percin, Gulce I., Günther, Marko, Rostovskaya, Maria, Krishnan, Shyam M., Oostendorp, Robert A.J., Dahl, Andreas, Anastassiadis, Konstantinos, Höfer, Thomas, and Waskow, Claudia
- Published
- 2019
- Full Text
- View/download PDF
28. Hematopoietic stem cell response to acute thrombocytopenia requires signaling through distinct receptor tyrosine kinases
- Author
-
Ramasz, Beáta, Krüger, Anja, Reinhardt, Julia, Sinha, Anupam, Gerlach, Michael, Gerbaulet, Alexander, Reinhardt, Susanne, Dahl, Andreas, Chavakis, Triantafyllos, Wielockx, Ben, and Grinenko, Tatyana
- Published
- 2019
- Full Text
- View/download PDF
29. SAT272 Insulin Signaling In Hyperactivation Of The HPA Axis In Metabolic Diseases
- Author
-
Cozma, Diana, primary, Siatra, Panagiota, additional, Oikonomakos, Ioannis, additional, Kalra, Diya, additional, Friedrich, Ulrike Anne, additional, Dahl, Andreas, additional, Bornstein, Stefan Richard, additional, Zeissig, Sebastian, additional, Andoniadou, Cynthia Lilian, additional, and Steenblock, Charlotte, additional
- Published
- 2023
- Full Text
- View/download PDF
30. Cellular senescence promotes progenitor cell expansion during axolotl limb regeneration
- Author
-
Yu, Qinghao, primary, Walters, Hannah E., additional, Pasquini, Giovanni, additional, Pal Singh, Sumeet, additional, Lachnit, Martina, additional, Oliveira, Catarina R., additional, León-Periñán, Daniel, additional, Petzold, Andreas, additional, Kesavan, Preethi, additional, Subiran Adrados, Cristina, additional, Garteizgogeascoa, Ines, additional, Knapp, Dunja, additional, Wagner, Anne, additional, Bernardos, Andrea, additional, Alfonso, María, additional, Nadar, Gayathri, additional, Graf, Alwin M., additional, Troyanovskiy, Konstantin E., additional, Dahl, Andreas, additional, Busskamp, Volker, additional, Martínez-Máñez, Ramón, additional, and Yun, Maximina H., additional
- Published
- 2023
- Full Text
- View/download PDF
31. SETD1A protects HSCs from activation-induced functional decline in vivo
- Author
-
Arndt, Kathrin, Kranz, Andrea, Fohgrub, Juliane, Jolly, Adrien, Bledau, Anita S., Di Virgilio, Michela, Lesche, Mathias, Dahl, Andreas, Höfer, Thomas, Stewart, A. Francis, and Waskow, Claudia
- Published
- 2018
- Full Text
- View/download PDF
32. Insm1 Induces Neural Progenitor Delamination in Developing Neocortex via Downregulation of the Adherens Junction Belt-Specific Protein Plekha7
- Author
-
Tavano, Stefania, Taverna, Elena, Kalebic, Nereo, Haffner, Christiane, Namba, Takashi, Dahl, Andreas, Wilsch-Bräuninger, Michaela, Paridaen, Judith T.M.L., and Huttner, Wieland B.
- Published
- 2018
- Full Text
- View/download PDF
33. Model Predictive Control of Marine Vessel Power System by Use of Structure Preserving Model
- Author
-
Dahl, Andreas Reason, Thorat, Laxminarayan, and Skjetne, Roger
- Published
- 2018
- Full Text
- View/download PDF
34. A smart polymer for sequence-selective binding, pulldown, and release of DNA targets
- Author
-
Krieg, Elisha, Gupta, Krishna, Dahl, Andreas, Lesche, Mathias, Boye, Susanne, Lederer, Albena, and Shih, William M.
- Published
- 2020
- Full Text
- View/download PDF
35. Fatty acid desaturase 2 determines the lipidomic landscape and steroidogenic function of the adrenal gland
- Author
-
Witt, Anke, primary, Mateska, Ivona, additional, Palladini, Alessandra, additional, Sinha, Anupam, additional, Wölk, Michele, additional, Harauma, Akiko, additional, Bechmann, Nicole, additional, Pamporaki, Christina, additional, Dahl, Andreas, additional, Rothe, Michael, additional, Kopaliani, Irakli, additional, Adolf, Christian, additional, Riester, Anna, additional, Wielockx, Ben, additional, Bornstein, Stefan R., additional, Kroiss, Matthias, additional, Peitzsch, Mirko, additional, Moriguchi, Toru, additional, Fedorova, Maria, additional, Grzybek, Michal, additional, Chavakis, Triantafyllos, additional, Mirtschink, Peter, additional, and Alexaki, Vasileia Ismini, additional
- Published
- 2023
- Full Text
- View/download PDF
36. Succinate mediates inflammation-induced adrenocortical dysfunction
- Author
-
Mateska, Ivona, primary, Witt, Anke, additional, Hagag, Eman, additional, Sinha, Anupam, additional, Yilmaz, Canelif, additional, Thanou, Evangelia, additional, Sun, Na, additional, Kolliniati, Ourania, additional, Patschin, Maria, additional, Abdelmegeed, Heba, additional, Henneicke, Holger, additional, Kanczkowski, Waldemar, additional, Wielockx, Ben, additional, Tsatsanis, Christos, additional, Dahl, Andreas, additional, Walch, Axel Karl, additional, Li, Ka Wan, additional, Peitzsch, Mirko, additional, Chavakis, Triantafyllos, additional, and Alexaki, Vasileia Ismini, additional
- Published
- 2023
- Full Text
- View/download PDF
37. Activation of the cGAS/STING Axis in Genome-Damaged Hematopoietic Cells Does Not Impact Blood Cell Formation or Leukemogenesis
- Author
-
Dressel, Nicole, primary, Natusch, Loreen, additional, Munz, Clara M., additional, Costas Ramon, Santiago, additional, Morcos, Mina N.F., additional, Loff, Anja, additional, Hiller, Björn, additional, Haase, Christa, additional, Schulze, Livia, additional, Müller, Patrick, additional, Lesche, Mathias, additional, Dahl, Andreas, additional, Luksch, Hella, additional, Rösen-Wolff, Angela, additional, Roers, Axel, additional, Behrendt, Rayk, additional, and Gerbaulet, Alexander, additional
- Published
- 2023
- Full Text
- View/download PDF
38. Virtual ontogeny of cortical growth preceding mental illness
- Author
-
German Research Foundation, University of Münster, National Health and Medical Research Council (Australia), University of Cape Town, National Research Foundation (South Africa), Swinburne University of Technology, Jack Brockhoff Foundation, University of Melbourne, Barbara Dicker Brain Sciences Foundation, Rebecca L. Cooper Medical Research Foundation, Society for Mental Health Research (Australia), Swedish Research Council, Swedish Foundation for Strategic Research, Swedish Brain Foundation, Health Research Board (Ireland), Russian Foundation for Basic Research, University of Zurich, Pratt Foundation, Ramsay Health Care, Viertel Charitable Foundation, Schizophrenia Research Institute (Australia), European Commission, Australian Research Council, Instituto de Salud Carlos III, National Institute for Health and Care Research (US), National Institute for Health Research (UK), Ministry of Health of the Czech Republic, Bill & Melinda Gates Foundation, South African Medical Research Council, Carnegie Corporation of New York, Wellcome Trust, Medical Research Council (UK), Medical Research Scotland, Netherlands Organization for Scientific Research, Ambrogi, Sonia [0000-0002-2897-358X], Banaschewski, Tobias [0000-0003-4595-1144], Bandeira, Cibele Edom [0000-0003-0681-1309], Cupertino, Renata [0000-0002-3452-0632], Calderoni, Sara [0000-0002-6250-5739], Cannon, Dara [0000-0001-7378-3411], Carr, Vaughan [0000-0002-8907-5804], Chew, Qian Hui [0000-0003-0969-7994], Coghill, David [0000-0003-3017-9737], Cullen, Kathryn [0000-0001-9631-3770], Dahl, Andreas [0000-0002-8097-2082], Epstein, Jeffery [0000-0003-3464-5256], Foran, William [0000-0001-7491-9798], Fortea, Lydia [0000-0001-6778-2316], Fuentes-Claramonte, Paola [0000-0002-1428-7976], Fullerton, Janice M. [0000-0003-4014-4490], Furlong, Lisa [0000-0001-6196-4565], Gallagher, Louise [0000-0001-9462-2836], Gao, Si [0000-0002-4473-1142], Gotlib, Ian [0000-0002-3622-3199], Haavik, Jan [0000-0001-7865-2808], Henskens, Frans [0000-0003-2358-5630], Hilland, Eva [0000-0002-7102-8372], Hoekstra, Pieter J [0000-0001-7260-4119], Howells, Fleur M [0000-0001-9759-2556], Ipser, Jonathan [0000-0003-1272-0032], Jørgensen, Jes Kristian [0000-0001-9133-1670], Karantonis, James A. [0000-0003-2281-0912], Lawrie, Stephen [0000-0002-2444-5675], Patel, Yash, Shin, Jean, Abé, Christoph, Agartz, Ingrid, Alloza, Clara, Alnæs, Dag, Ambrogi, Sonia, Antonucci, Linda A., Arango, Celso, Arolt, Volker, Auzias, Guillaume, Gruber, Oliver, Haavik, Jan, McDonald, Colm, Hahn, Tim, Harrison, Ben J., Heindel, Walter, Henskens, Frans, Heslenfeld, Dirk J., Hilland, Eva, King, Joseph A., Vernooij, Meike W., Hoekstra, Pieter J., Hohmann, Sarah, Holz, Nathalie, Howells, Fleur M., McIntosh, Andrew, Ipser, Jonathan C., Meinert, Susanne, Hoogman, Martine, Kircher, Tilo, Kochunov, Peter, Vieta, Eduard, Koopowitz, Sheri-Michelle, Landén, Mikael, Landrø, Nils Inge, Lawrie, Stephen, Michie, Patricia T., Ayesa Arriola, Rosa, Mitchell, Philip, Moreno-Alcázar, Ana, Franke, Barbara, Mowry, Bryan, Bau, Claiton H. D., Muratori, Filippo, Nabulsi, Leila, Nenadić, Igor, O'Gorman Tuura, Ruth, Oosterlaan, Jaap, Overs, Bronwyn, Pantelis, Christos, Banaj, Nerisa, Parellada, Mara, van Rooij, Daan, Vilarroya, Oscar, Pariente, Jose C., Pauli, Paul, Pergola, Giulio, Piarulli, Francesco Maria, Picon, Felipe, Piras, Fabrizio, Pomarol-Clotet, Edith, Pretus, Clara, Quidé, Yann, Banaschewski, Tobias, Weickert, Cynthia, Buitelaar, Jan, Radua, Joaquim, Ramos-Quiroga, J. Antoni, Rasser, Paul E., Reif, Andreas, Retico, Alessandra, Roberts, Gloria, Rossell, Susan, Rovaris, Diego Luiz, Rubia, Katya, Weickert, Thomas, Sacchet, Matthew, Ching, Christopher R. K., Bandeira, Cibele, Salavert, Josep, Salvador, Raymond, Sarró, Salvador, Sawa, Akira, Schall, Ulrich, Scott, Rodney, Selvaggi, Pierluigi, Westlye, Lars T., Silk, Tim, Sim, Kang, Andreassen, Ole A., Skoch, Antonin, Başgöze, Zeynep, Spalletta, Gianfranco, Spaniel, Filip, Stein, Dan J., Steinsträter, Olaf, Stolicyn, Aleks, Whalley, Heather, Takayanagi, Yoichiro, Tamm, Leanne, Tavares, Maria, Pozzi, Elena, Teumer, Alexander, Thiel, Katharina, Cupertino, Renata Basso, Thomopoulos, Sophia I., Tomecek, David, Tomyshev, Alexander S., Willinger, David, Tordesillas-Gutiérrez, Diana, Tosetti, Michela, Uhlmann, Anne, Van Rheenen, Tamsyn, Veltman, Dick, Vázquez-Bourgon, Javier, Schmaal, Lianne, Jahanshad, Neda, Winter, Alexandra, Wittfeld, Katharina, Yang, Tony T., Yoncheva, Yuliya, Bauer, Jochen, Zijlmans, Jendé L., Baumeister, Sarah, Lebedeva, Irina, van Erp, Theo G. M., Turner, Jessica, Jakobi, Babette, Castellanos, F. Xavier, Pausova, Zdenka, Thompson, Paul, Paus, Tomas, Bernardoni, Fabio, Bertolino, Alessandro, Bonnin, Caterina Del Mar, Brandeis, Daniel, Luna, Beatriz, Brem, Silvia, Jansen, Andreas, Bruggemann, Jason, Bülow, Robin, Bustillo, Juan R., Calderoni, Sara, Calvo, Rosa, Canales-Rodríguez, Erick J., Cannon, Dara M., Carmona, Susanna, Carr, Vaughan J., Lundervold, Astri J., Janssen, Joost, Catts, Stanley V., Chenji, Sneha, Chew, Qian Hui, Coghill, David, Connolly, Colm G., Conzelmann, Annette, Craven, Alexander R., Crespo-Facorro, Benedicto, Cullen, Kathryn, Dahl, Andreas, Jonassen, Rune, MacMaster, Frank P., Dannlowski, Udo, Davey, Christopher G., Deruelle, Christine, Díaz-Caneja, Covadonga M., Dohm, Katharina, Ehrlich, Stefan, Epstein, Jeffery, Erwin-Grabner, Tracy, Eyler, Lisa T., Kaiser, Anna, Fedor, Jennifer, Maglanoc, Luigi A., Fitzgerald, Jacqueline, Foran, William, Ford, Judith M., Fortea, Lydia, Fuentes-Claramonte, Paola, Fullerton, Janice, Furlong, Lisa, Gallagher, Louise, Kaleda, Vasiliy, Gao, Bingchen, Gao, Si, Mathalon, Daniel H., Goikolea, Jose M., Gotlib, Ian, Goya-Maldonado, Roberto, Grabe, Hans J., Green, Melissa, Grevet, Eugenio H., Groenewold, Nynke A., Karantonis, James, Grotegerd, Dominik., German Research Foundation, University of Münster, National Health and Medical Research Council (Australia), University of Cape Town, National Research Foundation (South Africa), Swinburne University of Technology, Jack Brockhoff Foundation, University of Melbourne, Barbara Dicker Brain Sciences Foundation, Rebecca L. Cooper Medical Research Foundation, Society for Mental Health Research (Australia), Swedish Research Council, Swedish Foundation for Strategic Research, Swedish Brain Foundation, Health Research Board (Ireland), Russian Foundation for Basic Research, University of Zurich, Pratt Foundation, Ramsay Health Care, Viertel Charitable Foundation, Schizophrenia Research Institute (Australia), European Commission, Australian Research Council, Instituto de Salud Carlos III, National Institute for Health and Care Research (US), National Institute for Health Research (UK), Ministry of Health of the Czech Republic, Bill & Melinda Gates Foundation, South African Medical Research Council, Carnegie Corporation of New York, Wellcome Trust, Medical Research Council (UK), Medical Research Scotland, Netherlands Organization for Scientific Research, Ambrogi, Sonia [0000-0002-2897-358X], Banaschewski, Tobias [0000-0003-4595-1144], Bandeira, Cibele Edom [0000-0003-0681-1309], Cupertino, Renata [0000-0002-3452-0632], Calderoni, Sara [0000-0002-6250-5739], Cannon, Dara [0000-0001-7378-3411], Carr, Vaughan [0000-0002-8907-5804], Chew, Qian Hui [0000-0003-0969-7994], Coghill, David [0000-0003-3017-9737], Cullen, Kathryn [0000-0001-9631-3770], Dahl, Andreas [0000-0002-8097-2082], Epstein, Jeffery [0000-0003-3464-5256], Foran, William [0000-0001-7491-9798], Fortea, Lydia [0000-0001-6778-2316], Fuentes-Claramonte, Paola [0000-0002-1428-7976], Fullerton, Janice M. [0000-0003-4014-4490], Furlong, Lisa [0000-0001-6196-4565], Gallagher, Louise [0000-0001-9462-2836], Gao, Si [0000-0002-4473-1142], Gotlib, Ian [0000-0002-3622-3199], Haavik, Jan [0000-0001-7865-2808], Henskens, Frans [0000-0003-2358-5630], Hilland, Eva [0000-0002-7102-8372], Hoekstra, Pieter J [0000-0001-7260-4119], Howells, Fleur M [0000-0001-9759-2556], Ipser, Jonathan [0000-0003-1272-0032], Jørgensen, Jes Kristian [0000-0001-9133-1670], Karantonis, James A. [0000-0003-2281-0912], Lawrie, Stephen [0000-0002-2444-5675], Patel, Yash, Shin, Jean, Abé, Christoph, Agartz, Ingrid, Alloza, Clara, Alnæs, Dag, Ambrogi, Sonia, Antonucci, Linda A., Arango, Celso, Arolt, Volker, Auzias, Guillaume, Gruber, Oliver, Haavik, Jan, McDonald, Colm, Hahn, Tim, Harrison, Ben J., Heindel, Walter, Henskens, Frans, Heslenfeld, Dirk J., Hilland, Eva, King, Joseph A., Vernooij, Meike W., Hoekstra, Pieter J., Hohmann, Sarah, Holz, Nathalie, Howells, Fleur M., McIntosh, Andrew, Ipser, Jonathan C., Meinert, Susanne, Hoogman, Martine, Kircher, Tilo, Kochunov, Peter, Vieta, Eduard, Koopowitz, Sheri-Michelle, Landén, Mikael, Landrø, Nils Inge, Lawrie, Stephen, Michie, Patricia T., Ayesa Arriola, Rosa, Mitchell, Philip, Moreno-Alcázar, Ana, Franke, Barbara, Mowry, Bryan, Bau, Claiton H. D., Muratori, Filippo, Nabulsi, Leila, Nenadić, Igor, O'Gorman Tuura, Ruth, Oosterlaan, Jaap, Overs, Bronwyn, Pantelis, Christos, Banaj, Nerisa, Parellada, Mara, van Rooij, Daan, Vilarroya, Oscar, Pariente, Jose C., Pauli, Paul, Pergola, Giulio, Piarulli, Francesco Maria, Picon, Felipe, Piras, Fabrizio, Pomarol-Clotet, Edith, Pretus, Clara, Quidé, Yann, Banaschewski, Tobias, Weickert, Cynthia, Buitelaar, Jan, Radua, Joaquim, Ramos-Quiroga, J. Antoni, Rasser, Paul E., Reif, Andreas, Retico, Alessandra, Roberts, Gloria, Rossell, Susan, Rovaris, Diego Luiz, Rubia, Katya, Weickert, Thomas, Sacchet, Matthew, Ching, Christopher R. K., Bandeira, Cibele, Salavert, Josep, Salvador, Raymond, Sarró, Salvador, Sawa, Akira, Schall, Ulrich, Scott, Rodney, Selvaggi, Pierluigi, Westlye, Lars T., Silk, Tim, Sim, Kang, Andreassen, Ole A., Skoch, Antonin, Başgöze, Zeynep, Spalletta, Gianfranco, Spaniel, Filip, Stein, Dan J., Steinsträter, Olaf, Stolicyn, Aleks, Whalley, Heather, Takayanagi, Yoichiro, Tamm, Leanne, Tavares, Maria, Pozzi, Elena, Teumer, Alexander, Thiel, Katharina, Cupertino, Renata Basso, Thomopoulos, Sophia I., Tomecek, David, Tomyshev, Alexander S., Willinger, David, Tordesillas-Gutiérrez, Diana, Tosetti, Michela, Uhlmann, Anne, Van Rheenen, Tamsyn, Veltman, Dick, Vázquez-Bourgon, Javier, Schmaal, Lianne, Jahanshad, Neda, Winter, Alexandra, Wittfeld, Katharina, Yang, Tony T., Yoncheva, Yuliya, Bauer, Jochen, Zijlmans, Jendé L., Baumeister, Sarah, Lebedeva, Irina, van Erp, Theo G. M., Turner, Jessica, Jakobi, Babette, Castellanos, F. Xavier, Pausova, Zdenka, Thompson, Paul, Paus, Tomas, Bernardoni, Fabio, Bertolino, Alessandro, Bonnin, Caterina Del Mar, Brandeis, Daniel, Luna, Beatriz, Brem, Silvia, Jansen, Andreas, Bruggemann, Jason, Bülow, Robin, Bustillo, Juan R., Calderoni, Sara, Calvo, Rosa, Canales-Rodríguez, Erick J., Cannon, Dara M., Carmona, Susanna, Carr, Vaughan J., Lundervold, Astri J., Janssen, Joost, Catts, Stanley V., Chenji, Sneha, Chew, Qian Hui, Coghill, David, Connolly, Colm G., Conzelmann, Annette, Craven, Alexander R., Crespo-Facorro, Benedicto, Cullen, Kathryn, Dahl, Andreas, Jonassen, Rune, MacMaster, Frank P., Dannlowski, Udo, Davey, Christopher G., Deruelle, Christine, Díaz-Caneja, Covadonga M., Dohm, Katharina, Ehrlich, Stefan, Epstein, Jeffery, Erwin-Grabner, Tracy, Eyler, Lisa T., Kaiser, Anna, Fedor, Jennifer, Maglanoc, Luigi A., Fitzgerald, Jacqueline, Foran, William, Ford, Judith M., Fortea, Lydia, Fuentes-Claramonte, Paola, Fullerton, Janice, Furlong, Lisa, Gallagher, Louise, Kaleda, Vasiliy, Gao, Bingchen, Gao, Si, Mathalon, Daniel H., Goikolea, Jose M., Gotlib, Ian, Goya-Maldonado, Roberto, Grabe, Hans J., Green, Melissa, Grevet, Eugenio H., Groenewold, Nynke A., Karantonis, James, and Grotegerd, Dominik.
- Abstract
[Background]: Morphology of the human cerebral cortex differs across psychiatric disorders, with neurobiology and developmental origins mostly undetermined. Deviations in the tangential growth of the cerebral cortex during pre/perinatal periods may be reflected in individual variations in cortical surface area later in life., [Methods]: Interregional profiles of group differences in surface area between cases and controls were generated using T1-weighted magnetic resonance imaging from 27,359 individuals including those with attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depressive disorder, schizophrenia, and high general psychopathology (through the Child Behavior Checklist). Similarity of interregional profiles of group differences in surface area and prenatal cell-specific gene expression was assessed., [Results]: Across the 11 cortical regions, group differences in cortical area for attention-deficit/hyperactivity disorder, schizophrenia, and Child Behavior Checklist were dominant in multimodal association cortices. The same interregional profiles were also associated with interregional profiles of (prenatal) gene expression specific to proliferative cells, namely radial glia and intermediate progenitor cells (greater expression, larger difference), as well as differentiated cells, namely excitatory neurons and endothelial and mural cells (greater expression, smaller difference). Finally, these cell types were implicated in known pre/perinatal risk factors for psychosis. Genes coexpressed with radial glia were enriched with genes implicated in congenital abnormalities, birth weight, hypoxia, and starvation. Genes coexpressed with endothelial and mural genes were enriched with genes associated with maternal hypertension and preterm birth., [Conclusions]: Our findings support a neurodevelopmental model of vulnerability to mental illness whereby prenatal risk factors acting through cell-specific processes lead to deviations from typical brain development during pregnancy.
- Published
- 2022
39. Shared pattern of impaired social communication and cognitive ability in the youth brain across diagnostic boundaries
- Author
-
Voldsbekk, Irene, primary, Kjelkenes, Rikka, additional, Wolfers, Thomas, additional, Dahl, Andreas, additional, Lund, Martina J., additional, Kaufmann, Tobias, additional, Fernandez-Cabello, Sara, additional, de Lange, Ann-Marie G., additional, Tamnes, Christian K., additional, Andreassen, Ole A., additional, Westlye, Lars T., additional, and Alnæs, Dag, additional
- Published
- 2023
- Full Text
- View/download PDF
40. Analysis of Electric Field Stimulation in Blue Light Stressed 661W Cells
- Author
-
Bola, Sharanya, primary, Subramanian, Pallavi, additional, Calzia, Daniela, additional, Dahl, Andreas, additional, Panfoli, Isabella, additional, Funk, Richard H. W., additional, and Roehlecke, Cora, additional
- Published
- 2023
- Full Text
- View/download PDF
41. Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic signature of islets from individuals with type 2 diabetes
- Author
-
Solimena, Michele, Schulte, Anke M., Marselli, Lorella, Ehehalt, Florian, Richter, Daniela, Kleeberg, Manuela, Mziaut, Hassan, Knoch, Klaus-Peter, Parnis, Julia, Bugliani, Marco, Siddiq, Afshan, Jörns, Anne, Burdet, Frédéric, Liechti, Robin, Suleiman, Mara, Margerie, Daniel, Syed, Farooq, Distler, Marius, Grützmann, Robert, Petretto, Enrico, Moreno-Moral, Aida, Wegbrod, Carolin, Sönmez, Anke, Pfriem, Katja, Friedrich, Anne, Meinel, Jörn, Wollheim, Claes B., Baretton, Gustavo B., Scharfmann, Raphael, Nogoceke, Everson, Bonifacio, Ezio, Sturm, Dorothée, Meyer-Puttlitz, Birgit, Boggi, Ugo, Saeger, Hans-Detlev, Filipponi, Franco, Lesche, Mathias, Meda, Paolo, Dahl, Andreas, Wigger, Leonore, Xenarios, Ioannis, Falchi, Mario, Thorens, Bernard, Weitz, Jürgen, Bokvist, Krister, Lenzen, Sigurd, Rutter, Guy A., Froguel, Philippe, von Bülow, Manon, Ibberson, Mark, and Marchetti, Piero
- Published
- 2017
- Full Text
- View/download PDF
42. CD38 promotes hematopoietic stem cell dormancy via c-Fos
- Author
-
Ibneeva, Liliia, Singh, Sumeet Pal, Sinha, A., Eski, Sema Elif, Wehner, Rebekka, Rupp, Luise, Perez-Valencia, Juan Alberto, Gerbaulet, Alexander, Reinhardt, Susanne, Wobus, Manja, Van Bonin, Malte, Sancho, Jaime, Lund, Frances, Dahl, Andreas, Schmitz, Marc, Bornhäuser, Martin, Chavakis, Triantafyllos, Wielockx, Ben, Grinenko, Tatyana, Ibneeva, Liliia, Singh, Sumeet Pal, Sinha, A., Eski, Sema Elif, Wehner, Rebekka, Rupp, Luise, Perez-Valencia, Juan Alberto, Gerbaulet, Alexander, Reinhardt, Susanne, Wobus, Manja, Van Bonin, Malte, Sancho, Jaime, Lund, Frances, Dahl, Andreas, Schmitz, Marc, Bornhäuser, Martin, Chavakis, Triantafyllos, Wielockx, Ben, and Grinenko, Tatyana
- Abstract
A subpopulation of deeply quiescent, so-called dormant hematopoietic stem cells (dHSCs) resides at the top of the hematopoietic hierarchy and serves as a reserve pool for HSCs possessing the greatest long-term blood repopulation capacity. The state of dormancy protects the HSC pool from exhaustion throughout life, however excessive dormancy may block an efficient response to hematological stresses. The mechanisms of HSC dormancy remain elusive, mainly due to the absence of surface markers that allow dHSC prompt isolation. Here, we identify CD38 as a novel surface marker for murine dHSCs that is broadly applicable. Moreover, we demonstrate that cyclic adenosine diphosphate ribose (cADPR), the product of CD38 cyclase activity, regulates the expression of the transcription factor c-Fos by increasing cytoplasmic Ca2+ concentration. Strikingly, we uncover that c-Fos drives HSCs dormancy through the induction of the cell cycle inhibitor p57Kip2. Moreover, we found that CD38 ecto-enzymatic activity at the neighboring CD38-positive cells can promote human HSC quiescence. Together, CD38/cADPR/Ca2+/cFos/p57Kip2 axis maintains HSC dormancy. Pharmacological manipulations of this pathway can provide new strategies to expand dHSCs for transplantation or to activate them during hematological stresses., info:eu-repo/semantics/published
- Published
- 2023
43. Fatty acid desaturase 2 determines the lipidomic landscape and steroidogenic function of the adrenal gland
- Author
-
Witt, Anke; https://orcid.org/0000-0003-4570-715X, Mateska, Ivona; https://orcid.org/0000-0001-6150-9175, Palladini, Alessandra; https://orcid.org/0000-0001-5307-8643, Sinha, Anupam, Wölk, Michele; https://orcid.org/0000-0001-5558-4582, Harauma, Akiko, Bechmann, Nicole; https://orcid.org/0000-0002-6932-333X, Pamporaki, Christina; https://orcid.org/0000-0003-0772-1604, Dahl, Andreas; https://orcid.org/0000-0002-2668-8371, Rothe, Michael, Kopaliani, Irakli; https://orcid.org/0000-0002-2884-3005, Adolf, Christian; https://orcid.org/0000-0002-9206-0953, Riester, Anna; https://orcid.org/0000-0003-3231-7435, Wielockx, Ben; https://orcid.org/0000-0002-4923-2596, Bornstein, Stefan R; https://orcid.org/0000-0002-5211-2536, Kroiss, Matthias; https://orcid.org/0000-0002-7628-3161, Peitzsch, Mirko; https://orcid.org/0000-0002-2472-675X, Moriguchi, Toru, Fedorova, Maria, Grzybek, Michal; https://orcid.org/0000-0003-2083-0506, Chavakis, Triantafyllos; https://orcid.org/0000-0002-1869-5141, Mirtschink, Peter; https://orcid.org/0000-0001-5832-1673, Alexaki, Vasileia Ismini; https://orcid.org/0000-0003-3935-8985, Witt, Anke; https://orcid.org/0000-0003-4570-715X, Mateska, Ivona; https://orcid.org/0000-0001-6150-9175, Palladini, Alessandra; https://orcid.org/0000-0001-5307-8643, Sinha, Anupam, Wölk, Michele; https://orcid.org/0000-0001-5558-4582, Harauma, Akiko, Bechmann, Nicole; https://orcid.org/0000-0002-6932-333X, Pamporaki, Christina; https://orcid.org/0000-0003-0772-1604, Dahl, Andreas; https://orcid.org/0000-0002-2668-8371, Rothe, Michael, Kopaliani, Irakli; https://orcid.org/0000-0002-2884-3005, Adolf, Christian; https://orcid.org/0000-0002-9206-0953, Riester, Anna; https://orcid.org/0000-0003-3231-7435, Wielockx, Ben; https://orcid.org/0000-0002-4923-2596, Bornstein, Stefan R; https://orcid.org/0000-0002-5211-2536, Kroiss, Matthias; https://orcid.org/0000-0002-7628-3161, Peitzsch, Mirko; https://orcid.org/0000-0002-2472-675X, Moriguchi, Toru, Fedorova, Maria, Grzybek, Michal; https://orcid.org/0000-0003-2083-0506, Chavakis, Triantafyllos; https://orcid.org/0000-0002-1869-5141, Mirtschink, Peter; https://orcid.org/0000-0001-5832-1673, and Alexaki, Vasileia Ismini; https://orcid.org/0000-0003-3935-8985
- Abstract
Corticosteroids regulate vital processes, including stress responses, systemic metabolism, and blood pressure. Here, we show that corticosteroid synthesis is related to the polyunsaturated fatty acid (PUFA) content of mitochondrial phospholipids in adrenocortical cells. Inhibition of the rate-limiting enzyme of PUFA synthesis, fatty acid desaturase 2 (FADS2), leads to perturbations in the mitochondrial lipidome and diminishes steroidogenesis. Consistently, the adrenocortical mitochondria of Fads2$^{-/-}$ mice fed a diet with low PUFA concentration are structurally impaired and corticoid levels are decreased. On the contrary, FADS2 expression is elevated in the adrenal cortex of obese mice, and plasma corticosterone is increased, which can be counteracted by dietary supplementation with the FADS2 inhibitor SC-26192 or icosapent ethyl, an eicosapentaenoic acid ethyl ester. In humans, FADS2 expression is elevated in aldosterone-producing adenomas compared to non-active adenomas or nontumorous adrenocortical tissue and correlates with expression of steroidogenic genes. Our data demonstrate that FADS2-mediated PUFA synthesis determines adrenocortical steroidogenesis in health and disease.
- Published
- 2023
44. Large-scale analysis of structural brain asymmetries in schizophrenia via the ENIGMA consortium
- Author
-
Schijven, Dick; https://orcid.org/0000-0001-5190-7241, Postema, Merel C; https://orcid.org/0000-0002-1536-7062, Fukunaga, Masaki; https://orcid.org/0000-0003-1010-2644, Matsumoto, Junya; https://orcid.org/0000-0003-4228-3208, Miura, Kenichiro, de Zwarte, Sonja M C, van Haren, Neeltje E M, Cahn, Wiepke, Hulshoff Pol, Hilleke E, Kahn, René S, Ayesa-Arriola, Rosa; https://orcid.org/0000-0003-0570-5352, de la Foz, Víctor Ortiz-García; https://orcid.org/0000-0002-0627-1827, Tordesillas-Gutierrez, Diana; https://orcid.org/0000-0003-1458-3932, Vázquez-Bourgon, Javier; https://orcid.org/0000-0002-5478-3376, Crespo-Facorro, Benedicto, Alnæs, Dag; https://orcid.org/0000-0001-7361-5418, Dahl, Andreas; https://orcid.org/0000-0002-2668-8371, Westlye, Lars T; https://orcid.org/0000-0001-8644-956X, Agartz, Ingrid, Andreassen, Ole A; https://orcid.org/0000-0002-4461-3568, Jönsson, Erik G, Kochunov, Peter, Bruggemann, Jason M, Catts, Stanley V, Michie, Patricia T, Mowry, Bryan J, Quidé, Yann, Rasser, Paul E; https://orcid.org/0000-0003-3482-721X, Schall, Ulrich; https://orcid.org/0000-0001-9041-4562, Scott, Rodney J; https://orcid.org/0000-0001-7724-3404, Carr, Vaughan J; https://orcid.org/0000-0002-8907-5804, Green, Melissa J; https://orcid.org/0000-0002-9361-4874, Henskens, Frans A; https://orcid.org/0000-0003-2358-5630, Loughland, Carmel M, Pantelis, Christos; https://orcid.org/0000-0002-9565-0238, Weickert, Cynthia Shannon, Weickert, Thomas W, de Haan, Lieuwe, Brosch, Katharina; https://orcid.org/0000-0002-0526-8095, Pfarr, Julia-Katharina, Ringwald, Kai G, Stein, Frederike, Jansen, Andreas, Kircher, Tilo T J, Nenadić, Igor, Krämer, Bernd; https://orcid.org/0000-0002-1145-9103, Gruber, Oliver; https://orcid.org/0000-0003-1841-7413, Satterthwaite, Theodore D; https://orcid.org/0000-0001-7072-9399, Bustillo, Juan; https://orcid.org/0000-0001-8730-8152, Mathalon, Daniel H, Preda, Adrian, Calhoun, Vince D; https://orcid.org/0000-0001-9058-0747, Ford, Judith M; https://orcid.org/0000-0002-6500-6548, Potkin, Steven G, Chen, Jingxu, Tan, Yunlong; https://orcid.org/0000-0002-3522-3912, Wang, Zhiren, Xiang, Hong, Fan, Fengmei, Bernardoni, Fabio, Ehrlich, Stefan; https://orcid.org/0000-0003-2132-4445, Fuentes-Claramonte, Paola; https://orcid.org/0000-0002-1428-7976, Garcia-Leon, Maria Angeles, Guerrero-Pedraza, Amalia, Salvador, Raymond; https://orcid.org/0000-0001-5557-1562, Sarró, Salvador; https://orcid.org/0000-0003-1835-2189, Pomarol-Clotet, Edith, Ciullo, Valentina; https://orcid.org/0000-0002-6870-6259, Piras, Fabrizio; https://orcid.org/0000-0003-3566-5494, Vecchio, Daniela, Banaj, Nerisa, Spalletta, Gianfranco; https://orcid.org/0000-0002-7432-4249, Michielse, Stijn, van Amelsvoort, Therese, Dickie, Erin W, Voineskos, Aristotle N; https://orcid.org/0000-0003-0156-0395, Sim, Kang; https://orcid.org/0000-0003-3209-9626, Ciufolini, Simone, Dazzan, Paola, Murray, Robin M; https://orcid.org/0000-0003-0829-0519, Kim, Woo-Sung, Chung, Young-Chul, Andreou, Christina, Schmidt, André; https://orcid.org/0000-0001-6055-8397, Borgwardt, Stefan; https://orcid.org/0000-0002-5792-3987, McIntosh, Andrew M, Whalley, Heather C, Lawrie, Stephen M; https://orcid.org/0000-0002-2444-5675, du Plessis, Stefan, Luckhoff, Hilmar K, Scheffler, Freda; https://orcid.org/0000-0002-8898-8599, Emsley, Robin, Grotegerd, Dominik, Lencer, Rebekka, Dannlowski, Udo; https://orcid.org/0000-0002-0623-3759, Edmond, Jesse T, Rootes-Murdy, Kelly, Stephen, Julia M, Mayer, Andrew R, Antonucci, Linda A, Fazio, Leonardo; https://orcid.org/0000-0003-4000-974X, Pergola, Giulio; https://orcid.org/0000-0002-9193-1841, Bertolino, Alessandro, Díaz-Caneja, Covadonga M; https://orcid.org/0000-0001-8538-3175, Janssen, Joost, Lois, Noemi G; https://orcid.org/0000-0002-6600-072X, Arango, Celso; https://orcid.org/0000-0003-3382-4754, Tomyshev, Alexander S, Lebedeva, Irina, Cervenka, Simon, Sellgren, Carl M, Georgiadis, Foivos, Kirschner, Matthias; https://orcid.org/0000-0002-9486-1439, Kaiser, Stefan, Hajek, Tomas, Skoch, Antonin; https://orcid.org/0000-0002-1739-3256, Spaniel, Filip, Kim, Minah; https://orcid.org/0000-0001-8668-0817, Kwak, Yoo Bin, Oh, Sanghoon; https://orcid.org/0000-0002-7394-5211, Kwon, Jun Soo; https://orcid.org/0000-0002-1060-1462, James, Anthony; https://orcid.org/0000-0002-2742-8328, Bakker, Geor, Knöchel, Christian, Stäblein, Michael, Oertel, Viola, Uhlmann, Anne; https://orcid.org/0000-0002-1753-7811, Howells, Fleur M, Stein, Dan J; https://orcid.org/0000-0001-7218-7810, Temmingh, Henk S; https://orcid.org/0000-0002-7688-0759, Diaz-Zuluaga, Ana M, Pineda-Zapata, Julian A, López-Jaramillo, Carlos, Homan, Stephanie; https://orcid.org/0000-0003-1449-7508, Ji, Ellen; https://orcid.org/0000-0003-1527-8868, Surbeck, Werner; https://orcid.org/0000-0002-4733-795X, Homan, Philipp; https://orcid.org/0000-0001-9034-148X, Fisher, Simon E; https://orcid.org/0000-0002-3132-1996, Franke, Barbara; https://orcid.org/0000-0003-4375-6572, Glahn, David C; https://orcid.org/0000-0002-4749-6977, Gur, Ruben C; https://orcid.org/0000-0002-9657-1996, Hashimoto, Ryota, Jahanshad, Neda, Luders, Eileen; https://orcid.org/0000-0001-5659-992X, Medland, Sarah E, Thompson, Paul M; https://orcid.org/0000-0002-4720-8867, Turner, Jessica A, van Erp, Theo G M, Francks, Clyde; https://orcid.org/0000-0002-9098-890X, Schijven, Dick; https://orcid.org/0000-0001-5190-7241, Postema, Merel C; https://orcid.org/0000-0002-1536-7062, Fukunaga, Masaki; https://orcid.org/0000-0003-1010-2644, Matsumoto, Junya; https://orcid.org/0000-0003-4228-3208, Miura, Kenichiro, de Zwarte, Sonja M C, van Haren, Neeltje E M, Cahn, Wiepke, Hulshoff Pol, Hilleke E, Kahn, René S, Ayesa-Arriola, Rosa; https://orcid.org/0000-0003-0570-5352, de la Foz, Víctor Ortiz-García; https://orcid.org/0000-0002-0627-1827, Tordesillas-Gutierrez, Diana; https://orcid.org/0000-0003-1458-3932, Vázquez-Bourgon, Javier; https://orcid.org/0000-0002-5478-3376, Crespo-Facorro, Benedicto, Alnæs, Dag; https://orcid.org/0000-0001-7361-5418, Dahl, Andreas; https://orcid.org/0000-0002-2668-8371, Westlye, Lars T; https://orcid.org/0000-0001-8644-956X, Agartz, Ingrid, Andreassen, Ole A; https://orcid.org/0000-0002-4461-3568, Jönsson, Erik G, Kochunov, Peter, Bruggemann, Jason M, Catts, Stanley V, Michie, Patricia T, Mowry, Bryan J, Quidé, Yann, Rasser, Paul E; https://orcid.org/0000-0003-3482-721X, Schall, Ulrich; https://orcid.org/0000-0001-9041-4562, Scott, Rodney J; https://orcid.org/0000-0001-7724-3404, Carr, Vaughan J; https://orcid.org/0000-0002-8907-5804, Green, Melissa J; https://orcid.org/0000-0002-9361-4874, Henskens, Frans A; https://orcid.org/0000-0003-2358-5630, Loughland, Carmel M, Pantelis, Christos; https://orcid.org/0000-0002-9565-0238, Weickert, Cynthia Shannon, Weickert, Thomas W, de Haan, Lieuwe, Brosch, Katharina; https://orcid.org/0000-0002-0526-8095, Pfarr, Julia-Katharina, Ringwald, Kai G, Stein, Frederike, Jansen, Andreas, Kircher, Tilo T J, Nenadić, Igor, Krämer, Bernd; https://orcid.org/0000-0002-1145-9103, Gruber, Oliver; https://orcid.org/0000-0003-1841-7413, Satterthwaite, Theodore D; https://orcid.org/0000-0001-7072-9399, Bustillo, Juan; https://orcid.org/0000-0001-8730-8152, Mathalon, Daniel H, Preda, Adrian, Calhoun, Vince D; https://orcid.org/0000-0001-9058-0747, Ford, Judith M; https://orcid.org/0000-0002-6500-6548, Potkin, Steven G, Chen, Jingxu, Tan, Yunlong; https://orcid.org/0000-0002-3522-3912, Wang, Zhiren, Xiang, Hong, Fan, Fengmei, Bernardoni, Fabio, Ehrlich, Stefan; https://orcid.org/0000-0003-2132-4445, Fuentes-Claramonte, Paola; https://orcid.org/0000-0002-1428-7976, Garcia-Leon, Maria Angeles, Guerrero-Pedraza, Amalia, Salvador, Raymond; https://orcid.org/0000-0001-5557-1562, Sarró, Salvador; https://orcid.org/0000-0003-1835-2189, Pomarol-Clotet, Edith, Ciullo, Valentina; https://orcid.org/0000-0002-6870-6259, Piras, Fabrizio; https://orcid.org/0000-0003-3566-5494, Vecchio, Daniela, Banaj, Nerisa, Spalletta, Gianfranco; https://orcid.org/0000-0002-7432-4249, Michielse, Stijn, van Amelsvoort, Therese, Dickie, Erin W, Voineskos, Aristotle N; https://orcid.org/0000-0003-0156-0395, Sim, Kang; https://orcid.org/0000-0003-3209-9626, Ciufolini, Simone, Dazzan, Paola, Murray, Robin M; https://orcid.org/0000-0003-0829-0519, Kim, Woo-Sung, Chung, Young-Chul, Andreou, Christina, Schmidt, André; https://orcid.org/0000-0001-6055-8397, Borgwardt, Stefan; https://orcid.org/0000-0002-5792-3987, McIntosh, Andrew M, Whalley, Heather C, Lawrie, Stephen M; https://orcid.org/0000-0002-2444-5675, du Plessis, Stefan, Luckhoff, Hilmar K, Scheffler, Freda; https://orcid.org/0000-0002-8898-8599, Emsley, Robin, Grotegerd, Dominik, Lencer, Rebekka, Dannlowski, Udo; https://orcid.org/0000-0002-0623-3759, Edmond, Jesse T, Rootes-Murdy, Kelly, Stephen, Julia M, Mayer, Andrew R, Antonucci, Linda A, Fazio, Leonardo; https://orcid.org/0000-0003-4000-974X, Pergola, Giulio; https://orcid.org/0000-0002-9193-1841, Bertolino, Alessandro, Díaz-Caneja, Covadonga M; https://orcid.org/0000-0001-8538-3175, Janssen, Joost, Lois, Noemi G; https://orcid.org/0000-0002-6600-072X, Arango, Celso; https://orcid.org/0000-0003-3382-4754, Tomyshev, Alexander S, Lebedeva, Irina, Cervenka, Simon, Sellgren, Carl M, Georgiadis, Foivos, Kirschner, Matthias; https://orcid.org/0000-0002-9486-1439, Kaiser, Stefan, Hajek, Tomas, Skoch, Antonin; https://orcid.org/0000-0002-1739-3256, Spaniel, Filip, Kim, Minah; https://orcid.org/0000-0001-8668-0817, Kwak, Yoo Bin, Oh, Sanghoon; https://orcid.org/0000-0002-7394-5211, Kwon, Jun Soo; https://orcid.org/0000-0002-1060-1462, James, Anthony; https://orcid.org/0000-0002-2742-8328, Bakker, Geor, Knöchel, Christian, Stäblein, Michael, Oertel, Viola, Uhlmann, Anne; https://orcid.org/0000-0002-1753-7811, Howells, Fleur M, Stein, Dan J; https://orcid.org/0000-0001-7218-7810, Temmingh, Henk S; https://orcid.org/0000-0002-7688-0759, Diaz-Zuluaga, Ana M, Pineda-Zapata, Julian A, López-Jaramillo, Carlos, Homan, Stephanie; https://orcid.org/0000-0003-1449-7508, Ji, Ellen; https://orcid.org/0000-0003-1527-8868, Surbeck, Werner; https://orcid.org/0000-0002-4733-795X, Homan, Philipp; https://orcid.org/0000-0001-9034-148X, Fisher, Simon E; https://orcid.org/0000-0002-3132-1996, Franke, Barbara; https://orcid.org/0000-0003-4375-6572, Glahn, David C; https://orcid.org/0000-0002-4749-6977, Gur, Ruben C; https://orcid.org/0000-0002-9657-1996, Hashimoto, Ryota, Jahanshad, Neda, Luders, Eileen; https://orcid.org/0000-0001-5659-992X, Medland, Sarah E, Thompson, Paul M; https://orcid.org/0000-0002-4720-8867, Turner, Jessica A, van Erp, Theo G M, and Francks, Clyde; https://orcid.org/0000-0002-9098-890X
- Abstract
Left-right asymmetry is an important organizing feature of the healthy brain that may be altered in schizophrenia, but most studies have used relatively small samples and heterogeneous approaches, resulting in equivocal findings. We carried out the largest case-control study of structural brain asymmetries in schizophrenia, using MRI data from 5,080 affected individuals and 6,015 controls across 46 datasets in the ENIGMA consortium, using a single image analysis protocol. Asymmetry indexes were calculated for global and regional cortical thickness, surface area, and subcortical volume measures. Differences of asymmetry were calculated between affected individuals and controls per dataset, and effect sizes were meta-analyzed across datasets. Small average case-control differences were observed for thickness asymmetries of the rostral anterior cingulate and the middle temporal gyrus, both driven by thinner left-hemispheric cortices in schizophrenia. Analyses of these asymmetries with respect to the use of antipsychotic medication and other clinical variables did not show any significant associations. Assessment of age- and sex-specific effects revealed a stronger average leftward asymmetry of pallidum volume between older cases and controls. Case-control differences in a multivariate context were assessed in a subset of the data (N = 2,029), which revealed that 7% of the variance across all structural asymmetries was explained by case-control status. Subtle case-control differences of brain macro-structural asymmetry may reflect differences at the molecular, cytoarchitectonic or circuit levels that have functional relevance for the disorder. Reduced left middle temporal cortical thickness is consistent with altered left-hemisphere language network organization in schizophrenia.
- Published
- 2023
45. RNAi profiling of primary human AML cells identifies ROCK1 as a therapeutic target and nominates fasudil as an antileukemic drug
- Author
-
Wermke, Martin, Camgoz, Aylin, Paszkowski-Rogacz, Maciej, Thieme, Sebastian, von Bonin, Malte, Dahl, Andreas, Platzbecker, Uwe, Theis, Mirko, Ehninger, Gerhard, Brenner, Sebastian, Bornhäuser, Martin, and Buchholz, Frank
- Published
- 2015
- Full Text
- View/download PDF
46. Isolation of macrophages from mouse skin wounds for single-cell RNA sequencing
- Author
-
Willenborg, Sebastian, primary, Roscito, Juliana G., additional, Gerbaulet, Alexander, additional, Roers, Axel, additional, Dahl, Andreas, additional, Eming, Sabine A., additional, and Reinhardt, Susanne, additional
- Published
- 2022
- Full Text
- View/download PDF
47. A gene expression map of host immune response in human brucellosis
- Author
-
Mitroulis, Ioannis, primary, Chrysanthopoulou, Akrivi, additional, Divolis, Georgios, additional, Ioannidis, Charalampos, additional, Ntinopoulou, Maria, additional, Tasis, Athanasios, additional, Konstantinidis, Theocharis, additional, Antoniadou, Christina, additional, Soteriou, Natalia, additional, Lallas, George, additional, Mitka, Stella, additional, Lesche, Mathias, additional, Dahl, Andreas, additional, Gembardt, Stephanie, additional, Panopoulou, Maria, additional, Sideras, Paschalis, additional, Wielockx, Ben, additional, Coskun, Ünal, additional, Ritis, Konstantinos, additional, and Skendros, Panagiotis, additional
- Published
- 2022
- Full Text
- View/download PDF
48. Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control
- Author
-
Brosch, Mario, Kattler, Kathrin, Herrmann, Alexander, von Schönfels, Witigo, Nordström, Karl, Seehofer, Daniel, Damm, Georg, Becker, Thomas, Zeissig, Sebastian, Nehring, Sophie, Reichel, Fabian, Moser, Vincent, Thangapandi, Raghavan Veera, Stickel, Felix, Baretton, Gustavo, Röcken, Christoph, Muders, Michael, Matz-Soja, Madlen, Krawczak, Michael, Gasparoni, Gilles, Hartmann, Hella, Dahl, Andreas, Schafmayer, Clemens, Walter, Jörn, and Hampe, Jochen
- Published
- 2018
- Full Text
- View/download PDF
49. Effects of different management regimes on microbial biodiversity in vineyard soils
- Author
-
Hendgen, Maximilian, Hoppe, Björn, Döring, Johanna, Friedel, Matthias, Kauer, Randolf, Frisch, Matthias, Dahl, Andreas, and Kellner, Harald
- Published
- 2018
- Full Text
- View/download PDF
50. Kollektivt minne og museum – Narvik 1940. Røde Kors Krigsminnemuseum og Narviksenterets rolle og funksjon som formidler av kollektive minner knyttet til krigshendelsene i og rundt Narvik i 1940
- Author
-
Dahl, Andreas and Aalmen Markussen, Joakim
- Subjects
VDP::Humaniora: 000::Historie: 070 ,Kollektivt minne ,HIS-3980 ,Museum - Abstract
Historien og de kollektive minnene om andre verdenskrig har mange forskjellige vinkler og tilnærminger, og museet har en helt sentral plass som formidler av disse. Røde Kors Krigsminnemuseum i Narvik åpnet i mars 1964. Gjennom en utvikling på over 50 år, har en institusjon for historisk formidling vært et bevaringssted for krigshistoriske gjenstander som har blitt presentert for et bredt utvalg av publikum. Fra 2016 gikk museet inn i en ny fase som innebar overgangen og utviklingen til det som nå er kjent som Narviksenteret. Museet som institusjon blir i seg selv et historisk åsted, med fortellinger som bidrar til å utvikle et minne om krigen. Denne studien ser på Røde Kors Krigsminnemuseum og Narviksenteret som forvalter og formidler av en fortelling om krigen i Narvik under andre verdenskrig. Ved å undersøke hvordan andre verdenskrig i Norge og Narvik har blitt fremstilt gjennom etterkrigstiden, kaster dette prosjektet lys på de mange prosessene og fasene Røde Kors Krigsminnemuseum og Narviksenteret har gjennomgått, og hvordan det kollektive minnet kan ha blitt påvirket av dette. Det kollektive minnet og fortellingen om andre verdenskrig har vært viktig for at nye generasjoner kan forstå å lære av tidligere hendelser. Et sentralt funn i denne undersøkelsen er at det har vært en klar utvikling bort fra det patriotiske narrativet som ble fremstilte i de tidlige fasene etter krigen. Det har gått fra å sette søkelys på motgang og seier hos Røde Kors Krigsminnemuseum, til mer generelle moralske spørsmål hos Narviksenteret.
- Published
- 2022
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.