1. Bradykinin as a pain mediator: receptors are localized to sensory neurons, and antagonists have analgesic actions.
- Author
-
Steranka LR, Manning DC, DeHaas CJ, Ferkany JW, Borosky SA, Connor JR, Vavrek RJ, Stewart JM, and Snyder SH
- Subjects
- Animals, Autoradiography, Bradykinin metabolism, Ganglia, Spinal drug effects, Ganglia, Spinal metabolism, Guinea Pigs, Muscle, Smooth innervation, Muscle, Smooth metabolism, Rats, Receptors, Bradykinin, Trigeminal Ganglion drug effects, Trigeminal Ganglion metabolism, Analgesia, Bradykinin antagonists & inhibitors, Neurons metabolism, Pain, Receptors, Neurotransmitter metabolism
- Abstract
Autoradiographic studies localize [3H]bradykinin receptor binding sites to the substantia gelatinosa, dorsal root, and a subset of small cells in both the dorsal root and trigeminal ganglia of the guinea pig. [3H]Bradykinin labeling is also observed over myocardial/coronary visceral afferent fibers. The localization of [3H]bradykinin receptors to nociceptive pathways supports a role for bradykinin in pain mediation. Several bradykinin antagonists block bradykinin-induced acute vascular pain in the rat. The bradykinin antagonists also relieve bradykinin- and urate-induced hyperalgesia in the rat paw. These results indicate that bradykinin is a physiologic mediator of pain and that bradykinin antagonists have analgesic activity in both acute and chronic pain models.
- Published
- 1988
- Full Text
- View/download PDF