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Your search keyword '"Di Trapani, Mariano"' showing total 13 results
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13 results on '"Di Trapani, Mariano"'

1. Rational of targeting WNT/beta-catenin signaling in acute myeloid leukemia (AML)

Author

Paul Takam Kamga, Adriana Cassaro, Bassi, Giulio, Giada Dal Collo, Adamo, Annalisa, Gatti, Alessandro, MARTINA MIDOLO, Carusone, Roberta, Di Trapani, Mariano, Resci, Federica, Massimiliano BONIFACIO, and Krampera, Mauro

Subjects
chemotherapy resistance, acute myeloid leukemia, WNT/beta catenin signaling, microenvironment, chemotherapy resistance, acute myeloid leukemia, microenvironment, WNT/beta catenin signaling
Published
2016

3. Inhibition of GSK-3 Signalling Enhances Sensitivity of Non-Promyelocitic Acute Myeloid Leukemia (AML) Cell to Chemotherapy

Author

Takam Kamga, Paul, primary, Dal Collo, Giada, additional, Cassaro, Adriana, additional, Adamo, Annalisa, additional, Gatti, Alessandro, additional, Carusone, Roberta, additional, Di Trapani, Mariano, additional, Midolo, Martina, additional, Resci, Federica, additional, Bonifacio, Massimiliano, additional, and Krampera, Mauro, additional

Published
2016
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6. Notch signalling drives bone marrow stromal cell-mediated chemoresistance in acute myeloid leukemia

Author

Kamga, Paul Takam, primary, Bassi, Giulio, additional, Cassaro, Adriana, additional, Midolo, Martina, additional, Di Trapani, Mariano, additional, Gatti, Alessandro, additional, Carusone, Roberta, additional, Resci, Federica, additional, Perbellini, Omar, additional, Gottardi, Michele, additional, Bonifacio, Massimiliano, additional, Kamdje, Armel Hervé Nwabo, additional, Ambrosetti, Achille, additional, and Krampera, Mauro, additional

Published
2016
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7. Effects Of a Novel Ceramic Biomaterial On Immune Modulatory Properties and Differentiation Potential Of Mesenchymal Stromal Cells

Author

Bassi, Giulio, primary, Menard, Cedric, additional, Guilloton, Fabien, additional, Pacelli, Luciano, additional, Carusone, Roberta, additional, Di Trapani, Mariano, additional, Zanoncello, Jasmina, additional, Bifari, Francesco, additional, Sensebé, Luc, additional, Deschaseaux, Fredric, additional, Baroth, Serge, additional, Schrezenmeier, Hubert, additional, Rojewski, Markus, additional, Layrolle, Pierre, additional, Giordano, Rosaria, additional, Lorenza, Lazzari, additional, Lavazza, Cristiana, additional, Bourin, Philippe, additional, Tarte, Karin, additional, and Krampera, Mauro, additional

Published
2013
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8. Immune Regulatory Properties Are a Common Feature Of Stem Cells

Author

Di Trapani, Mariano, primary, Bassi, Giulio, additional, Ricciardi, Mario, additional, Fontana, Emanuela, additional, Bifari, Francesco, additional, Pacelli, Luciano, additional, Giacomello, Luca, additional, Pozzobon, Michela, additional, Feron, Francois, additional, De Coppi, Paolo, additional, Anversa, Piero, additional, Fumagalli, Guido, additional, Decimo, Ilaria, additional, Menard, Cedric, additional, Tarte, Karin, additional, and Krampera, Mauro, additional

Published
2013
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11. Notch singalling inhibition as a multi-target therapy to overcome bone marrow microenvironment-mediated drug resistance in AML

Author

Paul Takam Kamga, Bassi, Giulio, Adriana Cassaro, Adamo, Annalisa, Gatti, Alessandro, Giada Dal Collo, MARTINA MIDOLO, Carusone, Roberta, Di Trapani, Mariano, Massimiliano BONIFACIO, and Krampera, Mauro

Subjects
chemotherapy resistance, acute myeloid leukemia, Notch signaling, microenvironment, chemotherapy resistance, acute myeloid leukemia, microenvironment, Notch signaling

12. Inhibition of Notch signalling overcomes bone marrow stromal-mediated anti-apoptotic and chemoresistance effects in AML

Author

Paul Takam Kamga, Bassi, Giulio, Adriana Cassaro, MARTINA MIDOLO, Di Trapani, Mariano, Canella, Francesca, Carusone, Roberta, Gatti, Alessandro, Resci, Federica, Perbellini, O., Gottardi, M., Massimiliano BONIFACIO, Nwabo Kamdje, Armel Herve, Ambrosetti, Achille, and Krampera, Mauro

Subjects
Acute Myeloid Leukemia, Notch signalling, Mesenchimal Stem Cells, Acute Myeloid Leukemia, Mesenchimal Stem Cells, Notch signalling

13. Notch signalling drives bone marrow stromal cell-mediated chemoresistance in acute myeloid leukemia.

Author

Takam Kamga P, Bassi G, Cassaro A, Midolo M, Di Trapani M, Gatti A, Carusone R, Resci F, Perbellini O, Gottardi M, Bonifacio M, Nwabo Kamdje AH, Ambrosetti A, and Krampera M

Subjects
Acute Disease, Adult, Aged, Cell Differentiation, Cell Line, Tumor, Cells, Cultured, Coculture Techniques, Drug Resistance, Neoplasm drug effects, Female, HL-60 Cells, Humans, K562 Cells, Leukemia, Myeloid pathology, Male, Middle Aged, Oligopeptides pharmacology, Receptors, Notch antagonists & inhibitors, Tumor Cells, Cultured, U937 Cells, Bone Marrow Cells metabolism, Leukemia, Myeloid metabolism, Mesenchymal Stem Cells metabolism, Receptors, Notch metabolism, Signal Transduction
Abstract

Both preclinical and clinical investigations suggest that Notch signalling is critical for the development of many cancers and for their response to chemotherapy. We previously showed that Notch inhibition abrogates stromal-induced chemoresistance in lymphoid neoplasms. However, the role of Notch in acute myeloid leukemia (AML) and its contribution to the crosstalk between leukemia cells and bone marrow stromal cells remain controversial. Thus, we evaluated the role of the Notch pathway in the proliferation, survival and chemoresistance of AML cells in co-culture with bone marrow mesenchymal stromal cells expanded from both healthy donors (hBM-MSCs) and AML patients (hBM-MSCs*). As compared to hBM-MSCs, hBM-MSCs* showed higher level of Notch1, Jagged1 as well as the main Notch target gene HES1. Notably, hBM-MSCs* induced expression and activation of Notch signalling in AML cells, supporting AML proliferation and being more efficientin inducing AML chemoresistance than hBM-MSCs*. Pharmacological inhibition of Notch using combinations of Notch receptor-blocking antibodies or gamma-secretase inhibitors (GSIs), in presence of chemotherapeutic agents, significant lowered the supportive effect of hBM-MSCs and hBM-MSCs* towards AML cells, by activating apoptotic cascade and reducing protein level of STAT3, AKT and NF-κB.These results suggest that Notch signalling inhibition, by overcoming the stromal-mediated promotion of chemoresistance,may represent a potential therapeutic targetnot only for lymphoid neoplasms, but also for AML., Competing Interests: The authors report no potential conflict of interest.

Published
2016
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