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Your search keyword '"Diabetes heterogeneity"' showing total 2 results
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2 results on '"Diabetes heterogeneity"'

1. Allostasis and the origins of adult-onset diabetes.

Author

Leslie, R. David and Vartak, Tanwi

Abstract

Physiological plasticity enables homeostasis to be maintained in biological systems, but when such allostasis fails, then disease can develop. In a new population-based study by Rolandsson et al (10.1007/s00125-019-05016-3), autoimmunity, defined by an immunogenotype, predicted adult-onset non-insulin requiring diabetes. Type 1 diabetes is no longer viewed as a disease confined to children, with a significant proportion, maybe the majority, presenting in adulthood. Such cases masquerade as type 2 diabetes and their identification has clinical utility. Nevertheless, in this study, autoimmunity had a limited effect on the overall risk of adults developing diabetes. [ABSTRACT FROM AUTHOR]

Published
2020
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2. Phosphotyrosine-protein-phosphatase and diabetic disorders. Further studies on the relationship between low molecular weight acid phosphatase genotype and degree of glycemic control

Author

Fulvia Gloria-Bottini, Paola Borgiani, Nunzio Bottini, E. Antonacci, Nazzareno Lucarini, and G. Faggioni

Subjects
Blood Glucose, Male, Clinical Biochemistry, Pregnancy in Diabetics, protein tyrosine phosphatase, Pregnancy, Genotype, Medicine, cLMW-PTP, Aged, 80 and over, education.field_of_study, lcsh:R5-920, diabetes heterogeneity, biology, diabetes, glycemic level, General Medicine, Middle Aged, Isoenzymes, Female, lcsh:Medicine (General), Adult, medicine.medical_specialty, Population, Acid Phosphatase, Internal medicine, Diabetes mellitus, Genetics, Diabetes Mellitus, Humans, Obesity, education, Molecular Biology, Glycemic, Aged, business.industry, Biochemistry (medical), Acid phosphatase, medicine.disease, Molecular Weight, Endocrinology, Diabetes Mellitus, Type 2, Settore MED/03 - Genetica Medica, biology.protein, Other, business, ACP1, Body mass index
Abstract

We have studied a new sample of 276 NIDDM patients from the population of Penne (Italy). Comparison of the new data with those of 214 diabetic pregnant women from the population of Rome reported in a previous paper has shown that the pattern of association between low molecular weight acid phosphatase genotype and degree of glycemic control is similar in the two classes of diabetic patients.Among nonobese subjects the proportion of ACP1*A (the allele showing the lowest enzymatic activity) is lower in diabetic patients with high glycemic levels (mean value greater than 8.9 mmol/l) than in diabetic patients with a low glycemic level (mean value less than 8.9 mmol/l). Among obese subjects no significant association is observed between glycemic levels and ACP1. Among nonobese subjects the concentration of f isoform of ACP1 is higher in patients showing a high glycemic level than in patients showing a low glycemic level. No significant difference is observed for s isoform.

Published
1998

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