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Urticaria is a common and complex disease, with a profound negative impact on the socio-economic quality of life, involving direct and indirect increased costs. According to studies, the prevalence of urticaria exceeds 20%. The authors have proposed to assess the impact of Helicobacter pylori infection on the response to antihistamine treatment in patients with chronic idiopathic urticaria. Helicobacter pylori eradication was associated with increased efflcacy of the antihistamines treatment in CIU patients. Eradication of Helicobacter pylori infection can lead to improvement of symptoms, even if it has no direct role in the etiology of chronic idiopathic urticaria. [ABSTRACT FROM AUTHOR]