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271 results on '"Dimitrova, R."'

1. Association of Insulin Resistance with Bone Mineral Density and Fracture Risk in Non-Diabetic Postmenopausal Women

Author

Dimitrova R. and Hristozov K.

Subjects
insulin resistance, bone mineral density, fracture risk, Medicine
Abstract

There is conflicting literature evidence regarding the independent effects of insulin resistance and concomitant hyperinsulinemia on bone mineral density. In addition, it is still under debate whether the net effect is favorable or unfavorable for the fracture risk. Therefore, we conducted a cross-sectional study.

Published
2023
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2. Multiwavelength behaviour of the blazar 3C279: decade-long study from $\gamma$-ray to radio

Author

Larionov, V. M., Jorstad, S. G., Marscher, A. P., Villata, M., Raiteri, C. M., Smith, P. S., Agudo, I., Savchenko, S. S., Morozova, D. A., Acosta-Pulido, J. A., Aller, M. F., Aller, H. D., Andreeva, T. S., Arkharov, A. A., Bachev, R., Bonnoli, G., Borman, G. A., Bozhilov, V., Calcidese, P., Carnerero, M. I., Carosati, D., Casadio, C., Chen, W. -P., Damljanovic, G., Dementyev, A. V., Di Paola, A., Frasca, A., Fuentes, A., Gómez, J. L., Gónzalez-Morales, P., Giunta, A., Grishina, T. S., Gurwell, M. A., Hagen-Thorn, V. A., Hovatta, T., Ibryamov, S., Joshi, M., Kiehlmann, S., Kim, J. -Y., Kimeridze, G. N., Kopatskaya, E. N., Kovalev, Yu. A., Kovalev, Y. Y., Kurtanidze, O. M., Kurtanidze, S. O., Lähteenmäki, A., Lázaro, C., Larionova, L. V., Larionova, E. G., Leto, G., Marchini, A., Matsumoto, K., Mihov, B., Minev, M., Mingaliev, M. G., Mirzaqulov, D., Dimitrova, R. V. Muñoz, Myserlis, I., Nikiforova, A. A., Nikolashvili, M. G., Nizhelsky, N. A., Ovcharov, E., Pressburger, L. D., Rakhimov, I. A., Righini, S., Rizzi, N., Sadakane, K., Sadun, A. C., Samal, M. R., Sanchez, R. Z., Semkov, E., Sergeev, S. G., Sigua, L. A., Slavcheva-Mihova, L., Sola, P., Sotnikova, Yu. V., Strigachev, A., Thum, C., Traianou, E., Troitskaya, Yu. V., Troitsky, I. S., Tsybulev, P. G., Vasilyev, A. A., Vince, O., Weaver, Z. R., Williamson, K. E., and Zhekanis, G. V.

Subjects
Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Astrophysics of Galaxies
Abstract

We report the results of decade-long (2008-2018) $\gamma$-ray to 1 GHz radio monitoring of the blazar 3C 279, including GASP/WEBT, $\it{Fermi}$ and $\it{Swift}$ data, as well as polarimetric and spectroscopic data. The X-ray and $\gamma$-ray light curves correlate well, with no delay > 3 hours, implying general co-spatiality of the emission regions. The $\gamma$-ray-optical flux-flux relation changes with activity state, ranging from a linear to a more complex dependence. The behaviour of the Stokes parameters at optical and radio wavelengths, including 43 GHz VLBA images, supports either a predominantly helical magnetic field or motion of the radiating plasma along a spiral path. Apparent speeds of emission knots range from 10 to 37c, with the highest values requiring bulk Lorentz factors close to those needed to explain $\gamma$-ray variability on very short time scales. The Mg II emission line flux in the `blue' and `red' wings correlates with the optical synchrotron continuum flux density, possibly providing a variable source of seed photons for inverse Compton scattering. In the radio bands we find progressive delays of the most prominent light curve maxima with decreasing frequency, as expected from the frequency dependence of the $\tau=1$ surface of synchrotron self-absorption. The global maximum in the 86 GHz light curve becomes less prominent at lower frequencies, while a local maximum, appearing in 2014, strengthens toward decreasing frequencies, becoming pronounced at $\sim5$ GHz. These tendencies suggest different Doppler boosting of stratified radio-emitting zones in the jet., Comment: 21 pages, 18 figures, accepted for publication in MNRAS

Published
2020
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3. Intra-night variability of the blazar CTA 102 during its 2012 and 2016 giant outbursts

Author

Bachev, R., Popov, V., Strigachev, A., Semkov, E., Ibryamov, S., Spassov, B., Latev, G., Dimitrova, R. V. Muñoz, and Boeva, S.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

We obtained and analyzed more than 100 hours of multicolour optical time series of the blazar CTA 102 during its 2012 and 2016 outbursts. The object reached almost 11-th mag at the end of 2016, which is perhaps the brightest blazar state ever observed! During both outbursts, CTA 102 showed significant and rapid variability on intra-night time scales, reaching up to 0.2 mag for 30 min on some occasions. The "rms-flux" relation, built for all datasets, shows a large scatter and no apparent saturation on the magnitude scale. The ensemble structure function of the light curves can be fitted well with a straight line of a slope of $\sim$0.4. The time lags between the different optical bands appear to be consistent with zero, taking into account our time resolution. We discuss different variability scenarios and favor the changing Doppler factor of the emitting blobs as the most plausible one to account for the observed intra-night variability., Comment: MNRAS, accepted

Published
2017
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4. C-FOG : Life of Coastal Fog

Author

Fernando, H. J. S., Gultepe, I., Dorman, C., Pardyjak, E., Wang, Q., Hoch, S. W, Richter, D., Creegan, E., Gaberšek, S., Bullock, T., Hocut, C., Chang, R., Alappattu, D., Dimitrova, R., Flagg, D., Grachev, A., Krishnamurthy, R., Singh, D. K., Lozovatsky, I., Nagare, B., Sharma, A., Wagh, S., Wainwright, C., Wroblewski, M., Yamaguchi, R., Bardoel, S., Coppersmith, R. S., Chisholm, N., Gonzalez, E., Gunawardena, N., Hyde, O., Morrison, T., Olson, A., Perelet, A., Perrie, W., Wang, S., and Wauer, B.

Published
2021

5. Multiband optical variability of the blazar OJ 287 during its outbursts in 2015 -- 2016

Author

Gupta, Alok C., Agarwal, A., Mishra, A., Gaur, H., Wiita, P. J., Gu, M. F., Kurtanidze, O. M., Damljanovic, G., Uemura, M., Semkov, E., Strigachev, A., Bachev, R., Vince, O., Zhang, Z., Villarroel, B., Kushwaha, P., Pandey, A., Abe, T., Chanishvili, R., Chigladze, R. A., Fan, J. H., Hirochi, J., Itoh, R., Kanda, Y., Kawabata, M., Kimeridze, G. N., Kurtanidze, S. O., Latev, G., Dimitrova, R. V. Muñoz, Nakaoka, T., Nikolashvili, M. G., Shiki, K., Sigua, L. A., and Spassov, B.

Subjects
Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

We present recent optical photometric observations of the blazar OJ 287 taken during September 2015 -- May 2016. Our intense observations of the blazar started in November 2015 and continued until May 2016 and included detection of the large optical outburst in December 2016 that was predicted using the binary black hole model for OJ 287. For our observing campaign, we used a total of 9 ground based optical telescopes of which one is in Japan, one is in India, three are in Bulgaria, one is in Serbia, one is in Georgia, and two are in the USA. These observations were carried out in 102 nights with a total of ~ 1000 image frames in BVRI bands, though the majority were in the R band. We detected a second comparably strong flare in March 2016. In addition, we investigated multi-band flux variations, colour variations, and spectral changes in the blazar on diverse timescales as they are useful in understanding the emission mechanisms. We briefly discuss the possible physical mechanisms most likely responsible for the observed flux, colour and spectral variability., Comment: 11 pages, 6 figures, 4 tables; Accepted for publication in MNRAS

Published
2016
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6. Subcortical volumetric abnormalities in bipolar disorder.

Author

Hibar, DP, Westlye, LT, van Erp, TGM, Rasmussen, J, Leonardo, CD, Faskowitz, J, Haukvik, UK, Hartberg, CB, Doan, NT, Agartz, I, Dale, AM, Gruber, O, Krämer, B, Trost, S, Liberg, B, Abé, C, Ekman, CJ, Ingvar, M, Landén, M, Fears, SC, Freimer, NB, Bearden, CE, Costa Rica/Colombia Consortium for Genetic Investigation of Bipolar Endophenotypes, Sprooten, E, Glahn, DC, Pearlson, GD, Emsell, L, Kenney, J, Scanlon, C, McDonald, C, Cannon, DM, Almeida, J, Versace, A, Caseras, X, Lawrence, NS, Phillips, ML, Dima, D, Delvecchio, G, Frangou, S, Satterthwaite, TD, Wolf, D, Houenou, J, Henry, C, Malt, UF, Bøen, E, Elvsåshagen, T, Young, AH, Lloyd, AJ, Goodwin, GM, Mackay, CE, Bourne, C, Bilderbeck, A, Abramovic, L, Boks, MP, van Haren, NEM, Ophoff, RA, Kahn, RS, Bauer, M, Pfennig, A, Alda, M, Hajek, T, Mwangi, B, Soares, JC, Nickson, T, Dimitrova, R, Sussmann, JE, Hagenaars, S, Whalley, HC, McIntosh, AM, Thompson, PM, and Andreassen, OA

Subjects
Costa Rica/Colombia Consortium for Genetic Investigation of Bipolar Endophenotypes, Brain, Humans, Magnetic Resonance Imaging, Organ Size, Case-Control Studies, Retrospective Studies, Bipolar Disorder, Adult, Middle Aged, Female, Male, Clinical Research, Mental Health, Brain Disorders, Serious Mental Illness, Neurosciences, Aetiology, 2.1 Biological and endogenous factors, Mental health, Biological Sciences, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry
Abstract

Considerable uncertainty exists about the defining brain changes associated with bipolar disorder (BD). Understanding and quantifying the sources of uncertainty can help generate novel clinical hypotheses about etiology and assist in the development of biomarkers for indexing disease progression and prognosis. Here we were interested in quantifying case-control differences in intracranial volume (ICV) and each of eight subcortical brain measures: nucleus accumbens, amygdala, caudate, hippocampus, globus pallidus, putamen, thalamus, lateral ventricles. In a large study of 1710 BD patients and 2594 healthy controls, we found consistent volumetric reductions in BD patients for mean hippocampus (Cohen's d=-0.232; P=3.50 × 10-7) and thalamus (d=-0.148; P=4.27 × 10-3) and enlarged lateral ventricles (d=-0.260; P=3.93 × 10-5) in patients. No significant effect of age at illness onset was detected. Stratifying patients based on clinical subtype (BD type I or type II) revealed that BDI patients had significantly larger lateral ventricles and smaller hippocampus and amygdala than controls. However, when comparing BDI and BDII patients directly, we did not detect any significant differences in brain volume. This likely represents similar etiology between BD subtype classifications. Exploratory analyses revealed significantly larger thalamic volumes in patients taking lithium compared with patients not taking lithium. We detected no significant differences between BDII patients and controls in the largest such comparison to date. Findings in this study should be interpreted with caution and with careful consideration of the limitations inherent to meta-analyzed neuroimaging comparisons.

Published
2016

7. Subcortical brain volume abnormalities in 2028 individuals with schizophrenia and 2540 healthy controls via the ENIGMA consortium

Author

van Erp, TGM, Hibar, DP, Rasmussen, JM, Glahn, DC, Pearlson, GD, Andreassen, OA, Agartz, I, Westlye, LT, Haukvik, UK, Dale, AM, Melle, I, Hartberg, CB, Gruber, O, Kraemer, B, Zilles, D, Donohoe, G, Kelly, S, McDonald, C, Morris, DW, Cannon, DM, Corvin, A, Machielsen, MWJ, Koenders, L, de Haan, L, Veltman, DJ, Satterthwaite, TD, Wolf, DH, Gur, RC, Gur, RE, Potkin, SG, Mathalon, DH, Mueller, BA, Preda, A, Macciardi, F, Ehrlich, S, Walton, E, Hass, J, Calhoun, VD, Bockholt, HJ, Sponheim, SR, Shoemaker, JM, van Haren, NEM, Pol, HEH, Ophoff, RA, Kahn, RS, Roiz-Santiañez, R, Crespo-Facorro, B, Wang, L, Alpert, KI, Jönsson, EG, Dimitrova, R, Bois, C, Whalley, HC, McIntosh, AM, Lawrie, SM, Hashimoto, R, Thompson, PM, and Turner, JA

Subjects
Biological Psychology, Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Psychology, Serious Mental Illness, Brain Disorders, Schizophrenia, Clinical Research, Neurosciences, Mental Health, Biomedical Imaging, Rare Diseases, Aetiology, 2.1 Biological and endogenous factors, Mental health, Good Health and Well Being, Adult, Brain, Brain Mapping, Case-Control Studies, Female, Functional Laterality, Humans, Image Processing, Computer-Assisted, Longitudinal Studies, Magnetic Resonance Imaging, Male, Middle Aged, Neuroimaging, Prospective Studies, Biological Sciences, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry, Clinical sciences, Biological psychology, Clinical and health psychology
Abstract

The profile of brain structural abnormalities in schizophrenia is still not fully understood, despite decades of research using brain scans. To validate a prospective meta-analysis approach to analyzing multicenter neuroimaging data, we analyzed brain MRI scans from 2028 schizophrenia patients and 2540 healthy controls, assessed with standardized methods at 15 centers worldwide. We identified subcortical brain volumes that differentiated patients from controls, and ranked them according to their effect sizes. Compared with healthy controls, patients with schizophrenia had smaller hippocampus (Cohen's d=-0.46), amygdala (d=-0.31), thalamus (d=-0.31), accumbens (d=-0.25) and intracranial volumes (d=-0.12), as well as larger pallidum (d=0.21) and lateral ventricle volumes (d=0.37). Putamen and pallidum volume augmentations were positively associated with duration of illness and hippocampal deficits scaled with the proportion of unmedicated patients. Worldwide cooperative analyses of brain imaging data support a profile of subcortical abnormalities in schizophrenia, which is consistent with that based on traditional meta-analytic approaches. This first ENIGMA Schizophrenia Working Group study validates that collaborative data analyses can readily be used across brain phenotypes and disorders and encourages analysis and data sharing efforts to further our understanding of severe mental illness.

Published
2016

8. THE PERDIGÃO : Peering into Microscale Details of Mountain Winds

Author

Fernando, H. J. S., Mann, J., Palma, J. M. L. M., Lundquist, J. K., Barthelmie, R. J., Belo-Pereira, M., Brown, W. O. J., Chow, F. K., Gerz, T., Hocut, C. M., Klein, P. M., Leo, L. S., Matos, J. C., Oncley, S. P., Pryor, S. C., Bariteau, L., Bell, T. M., Bodini, N., Carney, M. B., Courtney, M. S., Creegan, E. D., Dimitrova, R., Gomes, S., Hagen, M., Hyde, J. O., Kigle, S., Krishshnamurthy, R., Lopes, J. C., Mazzaro, L., Neher, J. M. T., Menke, R., Murphy, P., Oswald, L., Otarola-Bustos, S., Pattantyus, A. K., Rodrigues, C. Veiga, Schady, A., Sirin, N., Spuler, S., Svensson, E., Tomaszewski, J., Turner, D. D., van Veen, L., Vasiljević, N., Vasssallo, D., Voss, S., Wildmann, N., and Wang, Y.

Published
2019

9. Typifying the nervous system of small breed puppies and building a behavioral model for them.

Author

Halil, M., Dimitrova, R., and Stoycheva, I.

Subjects
*PUPPIES, *TEMPERAMENT, *DOG breeds, *NERVOUS system, *SOCIALIZATION
Abstract

The temperament of a total of 30 small puppies of 4 breeds in the period of their primary socialization was typified. The number of sanguines, cholerics, phlegmatics and melancholics was determined separately according to the breed of the animals along with the possibility of building a successful behavioral model for representatives of different breeds according to their temperament. The fastest socialization was reported in Shih Tzu puppies, followed by Bichon Frise, Pekingese, Dachshund, and lastly Poodle. There was a relationship between temperament and breed in dogs. [ABSTRACT FROM AUTHOR]

Published
2024
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11. THE MATERHORN : Unraveling the Intricacies of Mountain Weather

Author

Fernando, H. J. S., Pardyjak, E. R., Di Sabatino, S., Chow, F. K., De Wekker, S. F. J., Hoch, S. W., Hacker, J., Pace, J. C., Pratt, T., Pu, Z., Steenburgh, W. J., Whiteman, C. D., Wang, Y., Zajic, D., Balsley, B., Dimitrova, R., Emmitt, G. D., Higgins, C. W., Hunt, J. C. R., Knievel, J. C., Lawrence, D., Liu, Y., Nadeau, D. F., Kit, E., Blomquist, B. W., Conry, P., Coppersmith, R. S., Creegan, E., Felton, M., Grachev, A., Gunawardena, N., Hang, C., Hocut, C. M., Huynh, G., Jeglum, M. E., Jensen, D., Kulandaivelu, V., Lehner, M., Leo, L. S., Liberzon, D., Massey, J. D., McEnerney, K., Pal, S., Price, T., Sghiatti, M., Silver, Z., Thompson, M., Zhang, H., and Zsedrovits, T.

Published
2015

12. SUPPLEMENT : THE MATERHORN Unraveling the Intricacies of Mountain Weather

Author

Fernando, H. J. S., Pardyjak, E. R., Di Sabatino, S., Chow, F. K., De Wekker, S. F. J., Hoch, S. W., Hacker, J., Pace, J. C., Pratt, T., Pu, Z., Steenburgh, J. W., Whiteman, C. D., Wang, Y., Zajic, D., Balsley, B., Dimitrova, R., Emmitt, G. D., Higgins, C. W., Hunt, J. C. R., Knievel, J. C., Lawrence, D., Liu, Y., Nadeau, D. F., Kit, E., Blomquist, B. W., Conry, P., Coppersmith, R. S., Creegan, E., Felton, M., Grachev, A., Gunawardena, N., Hang, C., Hocut, C. M., Huynh, G., Jeglum, M. E., Jensen, D., Kulandaivelu, V., Lehner, M., Leo, L. S., Liberzon, D., Massey, J. D., McEnerney, K., Pal, S., Price, T., Sghiatti, M., Silver, Z., Thompson, M., Zhang, H., and Zsedrovits, T.

Published
2015

13. Chemical composition of seeds of four Bulgarian grape varieties

Author

Ovcharova Temenuzhka, Zlatanov M., and Dimitrova R.

Subjects
carbohydrates, grape seed oil, lipids, proteins, Plant culture, SB1-1110
Abstract

The composition of grape seeds from two white dessert (‘Bolgar’ and ‘Super ran Bolgar’) and two red wine Bulgarian varieties (‘Mavroud’ and ‘Shiroka melnishka loza’) was investigated. The content of proteins was established by Kjeldhal method and was found to be 6.3 – 8.9%. The content of carbohydrates - calculated as the difference of mean values: 100 - (amount in percentage of oil, moisture, protein and ash) - was 65.5 – 70.9%. The content of oil – by extraction with n-hexane - was 11.6 - 16.5%. The content of phospholipids was determined spectrophotometrically after isolation by chromatographic methods and was found to be 0.6 - 0.9%, including phosphatidylcholine, phosphatidylinositol and phosphatidic acids. The sterol content determined by gas chromatography was 0.3 – 0.4% while β-sitosterol (70.0 – 72.1%) and campesterol (18.5 – 19.9%) were the major components. In the phospholipids and sterol esters, saturated and monounsaturated fatty acids presented higher amount than the triacylglycerols. Fatty acids of sterol esters and phospholipids were determined by gas chromatography after isolation. The quantity of palmitic acid in the phospholipid fraction was 43.4 – 59.4%, the content of oleic acid was 9.0 – 14.0% and the content of linoleic acid was 10.0 – 24.5% while in the sterol esters, the predominant ones were mainly linoleic (40.7 – 53.8%), oleic (24.9 – 35.5%) and palmitic acids (13.0 – 16.7%). Linoleic (68.5 – 72.3%) and oleic acids (16.3 – 18.7%) were found to be the main components of the triacylglycerols. The tocopherol content varied from 67.7 mg kg-1 to 290.5 mg kg-1 where α-tocopherol (74.8 – 84.4%) was the predominant component.

Published
2016
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18. C-FOG Life of coastal fog

Author

Fernando, H.J.S., Gultepe, I., Dorman, C., Pardyjak, E., Wang, Q., Hoch, S.W, Richter, D., Creegan, E., Gaberšek, S., Bullock, T., Hocut, C., Chang, R., Alappattu, D., Dimitrova, R., Flagg, D., Grachev, A., Krishnamurthy, R., Singh, D.K., Lozovatsky, I., Nagare, B., Sharma, A., Wagh, S., Wainwright, C., Wroblewski, M., Yamaguchi, R., Bardoel, S., Coppersmith, R.S., Chisholm, N., Gonzalez, E., Gunawardena, N., Hyde, O., Morrison, T., Olson, A., Perelet, A., Perrie, W., Wang, S., Wauer, B., and Naval Postgraduate School (U.S.)

Subjects
Aerosols, Fog, Atmosphere-ocean interaction, Drop size distribution, Visibility, Atmosphere-land interaction
Abstract

17 USC 105 interim-entered record; under review. The article of record as published may be found at https://doi.org/10.1175/BAMS-D-19-0070.1 C-FOG is a comprehensive bi-national project dealing with the formation, persistence, and dissipation (life cycle) of fog in coastal areas (coastal fog) controlled by land, marine, and atmospheric processes. Given its inherent complexity, coastal-fog literature has mainly focused on case studies, and there is a continuing need for research that integrates across processes (e.g., air–sea–land interactions, environmental flow, aerosol transport, and chemistry), dynamics (two-phase flow and turbulence), microphysics (nucleation, droplet characterization), and thermodynamics (heat transfer and phase changes) through field observations and modeling. Central to C-FOG was a field campaign in eastern Canada from 1 September to 8 October 2018, covering four land sites in Newfoundland and Nova Scotia and an adjacent coastal strip transected by the Research Vessel Hugh R. Sharp. An array of in situ, path-integrating, and remote sensing instruments gathered data across a swath of space–time scales relevant to fog life cycle. Satellite and reanalysis products, routine meteorological observations, numerical weather prediction model (WRF and COAMPS) outputs, large-eddy simulations, and phenomenological modeling underpin the interpretation of field observations in a multiscale and multiplatform framework that helps identify and remedy numerical model deficiencies. An overview of the C-FOG field campaign and some preliminary analysis/findings are presented in this paper. This research was funded by ONR Grant N00014-18-1-2472 as a Multidisciplinary Initiative. The Pacific Northwest National Laboratory is operated by BattelleMemorial Institute for the DOE under Contract DE-AC05-76 RL01830

Published
2021

19. Seeing Fog Clearly: The C-FOG Research Program Addresses Predictability

Author

Fernando, H. J. S., primary, Gultepe, I., additional, Dorman, C., additional, Pardyjak, E., additional, Wang, Q., additional, Hoch, S. W, additional, Richter, D., additional, Creegan, E., additional, Gaberšek, S., additional, Bullock, T., additional, Hocut, C., additional, Chang, R., additional, Alappattu, D., additional, Dimitrova, R., additional, Flagg, D., additional, Grachev, A., additional, Krishnamurthy, R., additional, Singh, D. K., additional, Lozovatsky, I., additional, Nagare, B., additional, Sharma, A., additional, Wagh, S., additional, Wainwright, C., additional, Wroblewski, M., additional, Yamaguchi, R., additional, Bardoel, S., additional, Coppersmith, R. S., additional, Chisholm, N., additional, Gonzalez, E., additional, Gunawardena, N., additional, Hyde, O., additional, Morrison, T., additional, Olson, A., additional, Perelet, A., additional, Perrie, W., additional, Wang, S., additional, and Wauer, B., additional

Published
2021
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20. C-FOG Life of coastal fog

Author

Naval Postgraduate School (U.S.), Fernando, H.J.S., Gultepe, I., Dorman, C., Pardyjak, E., Wang, Q., Hoch, S.W, Richter, D., Creegan, E., Gaberšek, S., Bullock, T., Hocut, C., Chang, R., Alappattu, D., Dimitrova, R., Flagg, D., Grachev, A., Krishnamurthy, R., Singh, D.K., Lozovatsky, I., Nagare, B., Sharma, A., Wagh, S., Wainwright, C., Wroblewski, M., Yamaguchi, R., Bardoel, S., Coppersmith, R.S., Chisholm, N., Gonzalez, E., Gunawardena, N., Hyde, O., Morrison, T., Olson, A., Perelet, A., Perrie, W., Wang, S., Wauer, B., Naval Postgraduate School (U.S.), Fernando, H.J.S., Gultepe, I., Dorman, C., Pardyjak, E., Wang, Q., Hoch, S.W, Richter, D., Creegan, E., Gaberšek, S., Bullock, T., Hocut, C., Chang, R., Alappattu, D., Dimitrova, R., Flagg, D., Grachev, A., Krishnamurthy, R., Singh, D.K., Lozovatsky, I., Nagare, B., Sharma, A., Wagh, S., Wainwright, C., Wroblewski, M., Yamaguchi, R., Bardoel, S., Coppersmith, R.S., Chisholm, N., Gonzalez, E., Gunawardena, N., Hyde, O., Morrison, T., Olson, A., Perelet, A., Perrie, W., Wang, S., and Wauer, B.

Abstract

C-FOG is a comprehensive bi-national project dealing with the formation, persistence, and dissipation (life cycle) of fog in coastal areas (coastal fog) controlled by land, marine, and atmospheric processes. Given its inherent complexity, coastal-fog literature has mainly focused on case studies, and there is a continuing need for research that integrates across processes (e.g., air–sea–land interactions, environmental flow, aerosol transport, and chemistry), dynamics (two-phase flow and turbulence), microphysics (nucleation, droplet characterization), and thermodynamics (heat transfer and phase changes) through field observations and modeling. Central to C-FOG was a field campaign in eastern Canada from 1 September to 8 October 2018, covering four land sites in Newfoundland and Nova Scotia and an adjacent coastal strip transected by the Research Vessel Hugh R. Sharp. An array of in situ, path-integrating, and remote sensing instruments gathered data across a swath of space–time scales relevant to fog life cycle. Satellite and reanalysis products, routine meteorological observations, numerical weather prediction model (WRF and COAMPS) outputs, large-eddy simulations, and phenomenological modeling underpin the interpretation of field observations in a multiscale and multiplatform framework that helps identify and remedy numerical model deficiencies. An overview of the C-FOG field campaign and some preliminary analysis/findings are presented in this paper.

Published
2021

30. Erratum: Subcortical brain volume abnormalities in 2028 individuals with schizophrenia and 2540 healthy controls via the ENIGMA consortium

Author

van Erp, T G M, Hibar, D P, Rasmussen, J M, Glahn, D C, Pearlson, G D, Andreassen, O A, Agartz, I, Westlye, L T, Haukvik, U K, Dale, A M, Melle, I, Hartberg, C B, Gruber, O, Kraemer, B, Zilles, D, Donohoe, G, Kelly, S, McDonald, C, Morris, D W, Cannon, D M, Corvin, A, Machielsen, M W J, Koenders, L, de Haan, L, Veltman, D J, Satterthwaite, T D, Wolf, D H, Gur, R C, Gur, R E, Potkin, S G, Mathalon, D H, Mueller, B A, Preda, A, Macciardi, F, Ehrlich, S, Walton, E, Hass, J, Calhoun, V D, Bockholt, H J, Sponheim, S R, Shoemaker, J M, van Haren, N E M, Pol, H E H, Ophoff, R A, Kahn, R S, Roiz-Santiañez, R, Crespo-Facorro, B, Wang, L, Alpert, K I, Jönsson, E G, Dimitrova, R, Bois, C, Whalley, H C, McIntosh, A M, Lawrie, S M, Hashimoto, R, Thompson, P M, and Turner, J A

Published
2016
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31. Cortical morphology at birth reflects spatiotemporal patterns of gene expression in the fetal human brain

Author

Hilgetag, CC, Ball, G, Seidlitz, J, O'Muircheartaigh, J, Dimitrova, R, Fenchel, D, Makropoulos, A, Christiaens, D, Schuh, A, Passerat-Palmbach, J, Hutter, J, Cordero-Grande, L, Hughes, E, Price, A, Hajnal, J, Rueckert, D, Robinson, EC, Edwards, AD, Hilgetag, CC, Ball, G, Seidlitz, J, O'Muircheartaigh, J, Dimitrova, R, Fenchel, D, Makropoulos, A, Christiaens, D, Schuh, A, Passerat-Palmbach, J, Hutter, J, Cordero-Grande, L, Hughes, E, Price, A, Hajnal, J, Rueckert, D, Robinson, EC, and Edwards, AD

Abstract

Interruption to gestation through preterm birth can significantly impact cortical development and have long-lasting adverse effects on neurodevelopmental outcome. We compared cortical morphology captured by high-resolution, multimodal magnetic resonance imaging (MRI) in n = 292 healthy newborn infants (mean age at birth = 39.9 weeks) with regional patterns of gene expression in the fetal cortex across gestation (n = 156 samples from 16 brains, aged 12 to 37 postconceptional weeks [pcw]). We tested the hypothesis that noninvasive measures of cortical structure at birth mirror areal differences in cortical gene expression across gestation, and in a cohort of n = 64 preterm infants (mean age at birth = 32.0 weeks), we tested whether cortical alterations observed after preterm birth were associated with altered gene expression in specific developmental cell populations. Neonatal cortical structure was aligned to differential patterns of cell-specific gene expression in the fetal cortex. Principal component analysis (PCA) of 6 measures of cortical morphology and microstructure showed that cortical regions were ordered along a principal axis, with primary cortex clearly separated from heteromodal cortex. This axis was correlated with estimated tissue maturity, indexed by differential expression of genes expressed by progenitor cells and neurons, and engaged in stem cell differentiation, neuron migration, and forebrain development. Preterm birth was associated with altered regional MRI metrics and patterns of differential gene expression in glial cell populations. The spatial patterning of gene expression in the developing cortex was thus mirrored by regional variation in cortical morphology and microstructure at term, and this was disrupted by preterm birth. This work provides a framework to link molecular mechanisms to noninvasive measures of cortical development in early life and highlights novel pathways to injury in neonatal populations at increased risk of neurodevel

Published
2020

34. Multiwavelength behaviour of the blazar 3C 279: decade-long study from γ-ray to radio

Author

Larionov, V M, primary, Jorstad, S G, additional, Marscher, A P, additional, Villata, M, additional, Raiteri, C M, additional, Smith, P S, additional, Agudo, I, additional, Savchenko, S S, additional, Morozova, D A, additional, Acosta-Pulido, J A, additional, Aller, M F, additional, Aller, H D, additional, Andreeva, T S, additional, Arkharov, A A, additional, Bachev, R, additional, Bonnoli, G, additional, Borman, G A, additional, Bozhilov, V, additional, Calcidese, P, additional, Carnerero, M I, additional, Carosati, D, additional, Casadio, C, additional, Chen, W-P, additional, Damljanovic, G, additional, Dementyev, A V, additional, Di Paola, A, additional, Frasca, A, additional, Fuentes, A, additional, Gómez, J L, additional, Gónzalez-Morales, P, additional, Giunta, A, additional, Grishina, T S, additional, Gurwell, M A, additional, Hagen-Thorn, V A, additional, Hovatta, T, additional, Ibryamov, S, additional, Joshi, M, additional, Kiehlmann, S, additional, Kim, J-Y, additional, Kimeridze, G N, additional, Kopatskaya, E N, additional, Kovalev, Yu A, additional, Kovalev, Y Y, additional, Kurtanidze, O M, additional, Kurtanidze, S O, additional, Lähteenmäki, A, additional, Lázaro, C, additional, Larionova, L V, additional, Larionova, E G, additional, Leto, G, additional, Marchini, A, additional, Matsumoto, K, additional, Mihov, B, additional, Minev, M, additional, Mingaliev, M G, additional, Mirzaqulov, D, additional, Muñoz Dimitrova, R V, additional, Myserlis, I, additional, Nikiforova, A A, additional, Nikolashvili, M G, additional, Nizhelsky, N A, additional, Ovcharov, E, additional, Pressburger, L D, additional, Rakhimov, I A, additional, Righini, S, additional, Rizzi, N, additional, Sadakane, K, additional, Sadun, A C, additional, Samal, M R, additional, Sanchez, R Z, additional, Semkov, E, additional, Sergeev, S G, additional, Sigua, L A, additional, Slavcheva-Mihova, L, additional, Sola, P, additional, Sotnikova, Yu V, additional, Strigachev, A, additional, Thum, C, additional, Traianou, E, additional, Troitskaya, Yu V, additional, Troitsky, I S, additional, Tsybulev, P G, additional, Vasilyev, A A, additional, Vince, O, additional, Weaver, Z R, additional, Williamson, K E, additional, and Zhekanis, G V, additional

Published
2020
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38. From pattern classification to stratification: towards conceptualizing the heterogeneity of Autism Spectrum Disorder

Author

Wolfers, T., Floris, D.L., Dinga, R., Rooij, D. van, Isakoglou, C., Kia, S.M., Zabihi, M., Llera, A., Chowdanayaka, R., Kumar, V.J., Peng, H., Laidi, C., Batalle, D., Dimitrova, R., Charman, T., Loth, E., Lai, M.C., Jones, E.J.H., Baumeister, S., Moessnang, C., Banaschewski, T., Ecker, C., Dumas, G., O'Muircheartaigh, J., Murphy, D.G.M., Buitelaar, J.K., Marquand, A.F., Beckmann, C.F., Wolfers, T., Floris, D.L., Dinga, R., Rooij, D. van, Isakoglou, C., Kia, S.M., Zabihi, M., Llera, A., Chowdanayaka, R., Kumar, V.J., Peng, H., Laidi, C., Batalle, D., Dimitrova, R., Charman, T., Loth, E., Lai, M.C., Jones, E.J.H., Baumeister, S., Moessnang, C., Banaschewski, T., Ecker, C., Dumas, G., O'Muircheartaigh, J., Murphy, D.G.M., Buitelaar, J.K., Marquand, A.F., and Beckmann, C.F.

Abstract

Contains fulltext : 208638.pdf (publisher's version ) (Closed access), Pattern classification and stratification approaches have increasingly been used in research on Autism Spectrum Disorder (ASD) over the last ten years with the goal of translation towards clinical applicability. Here, we present an extensive scoping literature review on those two approaches. We screened a total of 635 studies, of which 57 pattern classification and 19 stratification studies were included. We observed large variance across pattern classification studies in terms of predictive performance from about 60% to 98% accuracy, which is among other factors likely linked to sampling bias, different validation procedures across studies, the heterogeneity of ASD and differences in data quality. Stratification studies were less prevalent with only two studies reporting replications and just a few showing external validation. While some identified strata based on cognition and intelligence reappear across studies, biology as a stratification marker is clearly underexplored. In summary, mapping biological differences at the level of the individual with ASD is a major challenge for the field now. Conceptualizing those mappings and individual trajectories that lead to the diagnosis of ASD, will become a major challenge in the near future.

Published
2019

39. The Perdigão: Peering into Microscale Details of Mountain Winds

Author

Fernando, H.J.S., Mann, Jakob, Palma, J.M.L.M., Lundquist, J.K., Barthelmie, Rebecca Jane, BeloPereira, M., Brown, W.O.J., Chow, F.K., Gerz, T., Hocut, C.M., Klein, P.M., Leo, L.S., Matos, J.C., Oncley, S.P., Pryor, S.C., Bariteau, L., Bell, T.M., Bodini, N., Carney, M.B., Courtney, M.S., Creegan, E.D., Dimitrova, R., Gomes, Sean, Hagen, Marie, Hyde, J.O., Kigle, S., Krishnamurthy, R., Lopes, J.C., Mazzaro, L., Neher, J.M.T., Menke, Robert, Murphy, P., Oswald, L., Otarola-Bustos, S., Pattantyus, A.K., Rodrigues, C. Veiga, Schady, A., Sirin, N., Spuler, S., Svensson, E., Tomaszewski, J., Turner, D.D., van Veen, L., Vasiljević, N., Vassallo, D., Voss, S., Wildmann, N., Wang, Y., Fernando, H.J.S., Mann, Jakob, Palma, J.M.L.M., Lundquist, J.K., Barthelmie, Rebecca Jane, BeloPereira, M., Brown, W.O.J., Chow, F.K., Gerz, T., Hocut, C.M., Klein, P.M., Leo, L.S., Matos, J.C., Oncley, S.P., Pryor, S.C., Bariteau, L., Bell, T.M., Bodini, N., Carney, M.B., Courtney, M.S., Creegan, E.D., Dimitrova, R., Gomes, Sean, Hagen, Marie, Hyde, J.O., Kigle, S., Krishnamurthy, R., Lopes, J.C., Mazzaro, L., Neher, J.M.T., Menke, Robert, Murphy, P., Oswald, L., Otarola-Bustos, S., Pattantyus, A.K., Rodrigues, C. Veiga, Schady, A., Sirin, N., Spuler, S., Svensson, E., Tomaszewski, J., Turner, D.D., van Veen, L., Vasiljević, N., Vassallo, D., Voss, S., Wildmann, N., and Wang, Y.

Abstract

A grand challenge from the wind energy industry is to provide reliable forecasts on mountain winds several hours in advance at microscale (∼100m) resolution. This requires better microscale wind energy physics included in forecasting tools, for which field observations are imperative. While mesoscale (∼ 1 km) measurements abound, microscale processes are not monitored in practice nor do plentiful measurements exist at this scale. After a decade of preparation, a group of European and US collaborators conducted a field campaign during May 01 – June 15, 2017 in Vale Cobrão in central Portugal to delve into microscale processes in complex terrain. This valley is nestled within a parallel double ridge near the town of Perdigão with dominant wind climatology normal to the ridges, offering a nominally simple yet natural setting for fundamental studies. The dense instrument ensemble deployed covered a ∼ 4 x 4 km swath horizontally and ∼ 10 km kilometers vertically, with measurement resolutions of tens of meters and seconds. Meteorological data were collected continuously, capturing multiscale flow interactions from synoptic to microscales, diurnal variability, thermal circulation, turbine wake and acoustics, waves and turbulence. Particularly noteworthy are the extensiveness of the instrument array, space-time scales covered, use of leading edge multiple-lidar technology alongside conventional tower and remote sensors, fruitful cross-Atlantic partnership, and adaptive management of the campaign. Preliminary data analysis uncovered interesting new phenomena. All data are being archived for public use.

Published
2019

40. Life of Coastal Fog.

Author

Fernando, H. J. S., Gultepe, I., Dorman, C., Pardyjak, E., Wang, Q., Hoch, S. W., Richter, D., Creegan, E., Gaberšek, S., Bullock, T., Hocut, C., Chang, R., Alappattu, D., Dimitrova, R., Flagg, D., Grachev, A., Krishnamurthy, R., Singh, D. K., Lozovatsky, I., and Nagare, B.

Published
2021
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43. The Robot Routing Problem for Collecting Aggregate Stochastic Rewards

Author

Dimitrova, R., Gavran, I., Majumdar, R., Prabhu, V., and Soudjani, S.

Subjects
FOS: Computer and information sciences, 000 Computer science, knowledge, general works, Systems and Control (eess.SY), Computational Complexity (cs.CC), Computer Science - Computational Complexity, Optimization and Control (math.OC), Computer Science - Computer Science and Game Theory, Computer Science - Data Structures and Algorithms, Computer Science, FOS: Electrical engineering, electronic engineering, information engineering, FOS: Mathematics, Computer Science - Systems and Control, Data Structures and Algorithms (cs.DS), Mathematics - Optimization and Control, Computer Science and Game Theory (cs.GT)
Abstract

We propose a new model for formalizing reward collection problems on graphs with dynamically generated rewards which may appear and disappear based on a stochastic model. The *robot routing problem* is modeled as a graph whose nodes are stochastic processes generating potential rewards over discrete time. The rewards are generated according to the stochastic process, but at each step, an existing reward disappears with a given probability. The edges in the graph encode the (unit-distance) paths between the rewards' locations. On visiting a node, the robot collects the accumulated reward at the node at that time, but traveling between the nodes takes time. The optimization question asks to compute an optimal (or epsilon-optimal) path that maximizes the expected collected rewards. We consider the finite and infinite-horizon robot routing problems. For finite-horizon, the goal is to maximize the total expected reward, while for infinite horizon we consider limit-average objectives. We study the computational and strategy complexity of these problems, establish NP-lower bounds and show that optimal strategies require memory in general. We also provide an algorithm for computing epsilon-optimal infinite paths for arbitrary epsilon > 0., 20 Pages. Full version of the CONCUR (28th International Conference on Concurrency Theory) 2017 paper

Published
2017

44. Multiband optical variability of the blazar OJ 287 during its outbursts in 2015-2016

Author

Gupta A., Agarwal A., Mishra A., Gaur H., Wiita P., Gu M., Kurtanidze O., Damljanovic G., Uemura M., Semkov E., Strigachev A., Bachev R., Vince O., Zhang Z., Villarroel B., Kushwaha P., Pandey A., Abe T., Chanishvili R., Chigladze R., Fan J., Hirochi J., Itoh R., Kanda Y., Kawabata M., Kimeridze G., Kurtanidze S., Latev G., Muñoz Dimitrova R., Nakaoka T., Nikolashvili M., Shiki K., Sigua L., and Spassov B.

Subjects
active [Galaxies], general [BL Lacertae objects], individual: OJ 287 [BL Lacertae objects]
Abstract

© 2016 The Authors.We present recent optical photometric observations of the blazar OJ 287 taken during 2015 September-2016 May. Our intense observations of the blazar started in 2015 November and continued until 2016 May and included detection of the large optical outburst in 2015 December that was predicted using the binary black hole model for OJ 287. For our observing campaign, we used a total of nine ground-based optical telescopes of which one is in Japan, one is in India, three are in Bulgaria, one is in Serbia, one is in Georgia, and two are in the USA. These observations were carried out in 102 nights with a total of ~1000 image frames in BVRI bands, though the majority were in the R band. We detected a second comparably strong flare in 2016 March. In addition, we investigated multiband flux variations, colour variations, and spectral changes in the blazar on diverse time-scales as they are useful in understanding the emission mechanisms. We briefly discuss the possible physical mechanisms most likely responsible for the observed flux, colour, and spectral variability.

Published
2017

45. Erratum: Subcortical brain volume abnormalities in 2028 individuals with schizophrenia and 2540 healthy controls via the ENIGMA consortium (Molecular Psychiatry (2015) DOI:10.1038/mp.2015.63)

Author

Van Erp, TGM, Hibar, DP, Rasmussen, JM, Glahn, DC, Pearlson, GD, Andreassen, OA, Agartz, I, Westlye, LT, Haukvik, UK, Dale, AM, Melle, I, Hartberg, CB, Gruber, O, Kraemer, B, Zilles, D, Donohoe, G, Kelly, S, Mcdonald, C, Morris, DW, Cannon, DM, Corvin, A, Machielsen, MWJ, Koenders, L, De Haan, L, Veltman, DJ, Satterthwaite, TD, Wolf, DH, Gur, RC, Gur, RE, Potkin, SG, Mathalon, DH, Mueller, BA, Preda, A, Macciardi, F, Ehrlich, S, Walton, E, Hass, J, Calhoun, VD, Bockholt, HJ, Sponheim, SR, Shoemaker, JM, Van Haren, NEM, Pol, HEH, Ophoff, RA, Kahn, RS, Roiz-Santiañez, R, Crespo-Facorro, B, Wang, L, Alpert, KI, Jönsson, EG, Dimitrova, R, Bois, C, Whalley, HC, Mcintosh, AM, Lawrie, SM, Hashimoto, R, Thompson, PM, and Turner, JA

Published
2016
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46. Erratum:Subcortical brain volume abnormalities in 2028 individuals with schizophrenia and 2540 healthy controls via the ENIGMA consortium

Author

van Erp, T. G M, Hibar, D. P., Rasmussen, J. M., Glahn, D. C., Pearlson, G. D., Andreassen, O. A., Agartz, I., Westlye, L. T., Haukvik, U. K., Dale, A. M., Melle, I., Hartberg, C. B., Gruber, O., Kraemer, B., Zilles, D., Donohoe, G., Kelly, S., McDonald, C., Morris, D. W., Cannon, D. M., Corvin, A., Machielsen, M. W J, Koenders, L., de Haan, L., Veltman, D. J., Satterthwaite, T. D., Wolf, D. H., Gur, R. C., Gur, R. E., Potkin, S. G., Mathalon, D. H., Mueller, B. A., Preda, A., Macciardi, F., Ehrlich, S., Walton, E., Hass, J., Calhoun, V. D., Bockholt, H. J., Sponheim, S. R., Shoemaker, J. M., van Haren, N. E M, Hulshoff Pol, H.E., Ophoff, R. A., Kahn, R. S., Roiz-Santiañez, R., Crespo-Facorro, B., Wang, L., Alpert, K. I., Jönsson, E. G., Dimitrova, R., Bois, C., Whalley, H. C., McIntosh, A. M., Lawrie, S. M., Hashimoto, R., Thompson, P. M., and Turner, J. A.

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Published Erratum, Molecular Biology
Published
2016

47. Serious Asthma Events with Fluticasone plus Salmeterol versus Fluticasone Alone

Author

Stempel, Da, Raphiou, Ih, Kral, Km, Yeakey, Am, Emmett, Ah, Prazma, Cm, Buaron, Ks, Pascoe, Sj, Austri, Investigators, Altieri, Hh, Antuni, Jd, Bergna, Ma, Cuadrado, Ja, De Gennaro MS, Fazio Lizandrelo CL, Gattolin, G, Gosn, Am, Larrateguy, Ld, Marcipar, Am, Maspero, Jf, Medina, Iv, Perez Chada RD, Silva, D, Victorio, Cf, Bardin, Pg, Carroll, Pa, Clements, Bs, Dore, Nd, Robinson, Pd, Fitzgerald, Da, Robinson, Pj, Russo, Ma, Sajkov, D, Thomas, Ps, Upham, Jw, Forstner, B, Kaik, G, Koeberl, Gh, Studnicka, M, Wallner, G, Balthazar, Y, Bauler, A, Dupont, Lj, Martinot, Jb, Ninane, V, Peché, R, Pilette, C, Dimitrova, R, Dimova, D, Kissyova Ibrishimova, G, Loboshka Becheva, M, Machkovska, M, Madjarov, S, Mandazhieva Pepelanova, M, Naidenova, I, Noleva, K, Takovska, N, Terziev, C, Aggarwal, Nk, Chapman, Kr, Csanadi, Ma, Dhillon, R, Henein, S, Kelly, Aj, Lam, As, Liem, Jj, Lougheed, Md, Lowe, Dw, Rizvi, Q, van den Berg, L, Zidel, B, Barros Monge MJ, Calvo Gil MA, Castillo Hofer CR, Diaz Amor PV, Lezana Soya, V, Quilodran Silva CN, Bolivar Grimaldos, F, Solarte-Rodriguez, I, Butkovic-Tomljanovic, R, Hegedus-Jungvirth, M, Ivkovic-Jurekovic, I, Simunov-Karuza, G, Buresova, M, Bursova, J, Fratrik, J, Guttlerova, E, Hartman, P, Jirmanova, I, Kalina, P, Kolman, P, Kucera, M, Povysilova, L, Pravda, P, Svabkova, A, Zakova, L, Backer, V, Maltbaek, N, Johnsen, Cr, Aries, Sp, Babyesiza, A, Barth, D, Benedix, A, Berg, P, Bergtholdt, B, Bettig, U, Bindig, Hw, Botzen, U, Brehler, R, Breyer, Go, Bruckhaus-Walter, M, Dapper, T, Eckhard, Jg, Engelhard, R, Feldmeyer, F, Fissan, H, Franz, Kh, Frick, Bs, Funck, J, Gessner, Cm, Ginko, T, Grigat, Ce, Grimm-Sachs, V, Groth, G, Hampf, J, Hanf, G, Havasi-Jost, G, Heinz, Gu, Helm, K, Hoeltz, S, Hofmann, S, Jander, R, Jandl, M, Jasch-Hoppe, B, Jung, T, Junggeburth, Jj, Kardos, P, Knueppel, W, Koch, T, Kolorz, C, Korduan, M, Korth-Wiemann, B, Krezdorn, Hg, Kroker, A, Kruell, M, Kuehne, P, Lenk, U, Liefring, E, Merke, J, Micke, L, Mitlehner, W, Mueller, H, Naudts, If, Neumann, G, Oldenburg, W, Overlack, A, Panzer, F, Reinholz, N, Remppis, R, Riegel, P, Rueckert, P, Schaetzl, Rj, Schauer, U, Hamelmann, E, Schenkenberger, I, Schlegel, V, Scholz, G, Schroers, M, Schwittay, A, Sebert, M, Tyler, K, Soemantri, Pa, Stock, P, Stuchlik, G, Unland, M, von Mallinckrodt, C, Wachter, J, Weber, U, Weberling, F, Wehgartner-Winkler, S, Weimer, J, Wiemer, S, Winkelmann, Ej, Zeisler, Kh, Ziegner, A, Zimny, Hh, Andrasofszky, Z, Bartha, A, Farkas, M, Gömöri, K, Kis, S, Major, K, Mészáros, I, Mezei, M, Rakvacs, M, Szalai, Z, Szántó, J, Szentesi, M, Szolnoki, E, Valyon, E, Zibotics, H, Anwar, J, Arimah, C, Djajalaksana, S, Rai, Ib, Setijadi, Ar, Setyanto, Db, Susanti, F, Syafiuddin, T, Syamsi, Ln, Wijanarko, P, Yunus, F, Bonavia, M, Braga, M, Chetta, Aa, Cerveri, I, Luisetti, M, Crimi, N, Cutrera, R, De Rosa, M, Esposito, S, Foresi, A, Gammeri, E, Iemoli, E, Legnani, Dl, Michetti, G, Pastorello, Ea, Pesci, A, Pistolesi, M, Riva, E, Romano, A, Scichilone, N, Terracciano, L, Tripodi, S, Choi, I, Kim, C, Kim, Js, Kim, Wj, Koh, Yy, Kwon, Ss, Lee, Sh, Lee, S, Lee, Sk, Park, Cs, Cirule, I, Eglite, R, Petrova, I, Poga, M, Smiltena, I, Chomiciene, A, Davoliene, I, Griskeviciene, V, Naudziunas, A, Naudziunas, S, Rudzeviciene, O, Sitkauskiene, B, Urbonas, G, Vaicius, D, Valavicius, A, Valiulis, A, Vebriene, J, bin Abdul Aziz FA, Daud, M, Ismail, Ai, Tengku Saifudin TI, Md Kassim RM, Mohd Fadzli FB, Wan Mohamad WH, Aguilar Dominguez PE, Aguilar-Orozco, Ra, Garza-Salinas, S, Ramirez-Diaz, Sp, Sánchez Llamas, F, Soto-Ramos, M, Velarde-Mora, Hj, Aguirre Sosa, I, Cisneros, Am, Estrella Viladegut RA, Matsuno Fuchigami, A, Adiaz-Baui, Tt, Bernan, Ap, Onia, Af, Sandagon, Mj, S-Naval, S, Yu, Cy, Bartuzi, Z, Bielous-Wilk, A, Błażowski, Ł, Bożek, A, Brzostek, J, Chorostowska-Wynimko, J, Ciekalska, K, Ziora, D, Cieslicki, J, Emeryk, A, Folcik, K, Gałuszka-Bilińska, A, Gawlik, R, Giejlo, M, Harat, R, Hofman, T, Jahnz-Różyk, K, Jedrzejczak, M, Kachel, T, Kamiński, D, Kelm Warchol, A, Konieczny, Z, Kwasniewski, A, Leszczyński, W, Mincewicz, G, Niezgoda, K, Olszewska-Ziąber, A, Onasz-Manitius, M, Pawlukiewicz, M, Piotrowicz, P, Piotrowski, W, Pisarczyk-Bogacka, E, Piskorz, P, Prokop-Staszecka, A, Roslan, A, Słomka, A, Smalera, E, Stelmach, I, Swierczynska-Krepa, M, Szmidt, M, Tarnowska-Matusiak, M, Tłuczykont, B, Tyminska, K, Waszkuc-Golonko, J, Wojciechowska, I, Alexandrescu, Ds, Neamtu, Ml, Todea, D, Alekseeva, E, Aleksandrova, E, Asherova, I, Barbarash, Ol, Bugrova, O, Bukreeva, Eb, Chermenskiy, A, Chizhova, O, Demko, I, Evdokimova, A, Giorgadze, Ml, Grigoryev, S, Irkhina, I, Khurkhurova, Nv, Kondyurina, Eg, Kostin, Vi, Kudelya, L, Laleko, Sl, Lenskaya, L, Levashov, S, Logvinenko, N, Martynov, A, Mizernitski, Y, Nemtsov, B, Novozhenov, Vg, Pavlishchuk, S, Popova, Vv, Reshetko, Ov, Sherenkov, A, Shirinsky, Vs, Shpagina, L, Soloviev, Ki, Tkachev, A, Trofimov, Vi, Vertkin, Al, Vorobeva, E, Idrisova, E, Yakushin, S, Zadionchenko, V, Zhiglinskaya, O, Zykov, K, Dopudja Pantic, V, Nadaskic, R, Nestorovic, B, Skodric Trifunovic, V, Stojanovic, A, Vukcevic, M, Vujic, T, Mitic Milikic, M, Banovcin, P, Horvathova, H, Karako, P Sr, Plutinsky, J, Pribulova, E, Szarazova, M, Zlatos, A, Adams, L, Badat, A, Bassa, A, Breedt, J, Bruning, A, Ellis, Gc, Emanuel, S, Fouche, Lf, Fulat, Ma, Gani, M, Ismail, Ms, Jurgens, Jc, Nell, H, Nieuwoudt, G, Noor, F, Bolliger, Ct, Puterman, As, Siddique, N, Trokis, Js, Vahed, Ya, Van Der Berg BJ, Van der Linden, M, Van Zyl, L, Visser, Ss, Antépara Ercoreca, I, Arnedillo Muñoz, A, Barbe Illa, F, Barreiro López, B, Blanco Aparicio, M, Boada Valmaseda, A, Bosque García, M, Bustamante Ruiz, A, Carretero Anibarro, P, Del Campo Matias, F, Echave-Sustaet, Jm, Espinosa de los Monteros Garde MJ, Garcia Hernandez GM, López Viña, A, Lores Obradors, L, Luengo Planas MT, Monsó Molas, E, Navarro Dourdil, A, Nieto García AJ, Perpina Tordera, M, Picado Valles, C, Rodriguez Alvarez Mdel, M, Saura Vinuesa, A, 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Scichilone N tra i collaboratori

Subjects
Male, asthma, serious events, fluticasone, salmeterol, AUSTRI, Exacerbation, Intention to Treat Analysi, INHALED CORTICOSTEROIDS, Severity of Illness Index, law.invention, 0302 clinical medicine, Randomized controlled trial, law, immune system diseases, Ús terapèutic, Broncodilatadors, 030212 general & internal medicine, Child, Fluticasone, RISK, ACTING BETA-AGONISTS, EXACERBATIONS, METAANALYSIS, MORTALITY, SAFETY, DEATH, FDA, Medicine (all), Hazard ratio, General Medicine, Bronchodilator agents, Middle Aged, Fluticasone-Salmeterol Drug Combination, Bronchodilator Agents, Intention to Treat Analysis, Anesthesia, Female, Salmeterol, medicine.drug, Human, Adult, medicine.medical_specialty, Adolescent, Settore MED/10 - Malattie Dell'Apparato Respiratorio, Fluticasone propionate, 03 medical and health sciences, Double-Blind Method, Internal medicine, Administration, Inhalation, medicine, Humans, Asma, Bronchodilator Agent, Asthma, Aged, Proportional Hazards Models, business.industry, Therapeutic use, medicine.disease, respiratory tract diseases, 030228 respiratory system, Fluticasone Propionate, Salmeterol Xinafoate Drug Combination, Proportional Hazards Model, business
Abstract

BACKGROUND The safe and appropriate use of long-acting beta-agonists (LABAs) for the treatment of asthma has been widely debated. In two large clinical trials, investigators found a potential risk of serious asthma-related events associated with LABAs. This study was designed to evaluate the risk of administering the LABA salmeterol in combination with an inhaled glucocorticoid, fluticasone propionate. METHODS In this multicenter, randomized, double-blind trial, adolescent and adult patients (age, ≥12 years) with persistent asthma were assigned to receive either fluticasone with salmeterol or fluticasone alone for 26 weeks. All the patients had a history of a severe asthma exacerbation in the year before randomization but not during the previous month. Patients were excluded from the trial if they had a history of lifethreatening or unstable asthma. The primary safety end point was the first serious asthma-related event (death, endotracheal intubation, or hospitalization). Noninferiority of fluticasone–salmeterol to fluticasone alone was defined as an upper boundary of the 95% confidence interval for the risk of the primary safety end point of less than 2.0. The efficacy end point was the first severe asthma exacerbation. RESULTS Of 11,679 patients who were enrolled, 67 had 74 serious asthma-related events, with 36 events in 34 patients in the fluticasone–salmeterol group and 38 events in 33 patients in the fluticasone-only group. The hazard ratio for a serious asthmarelated event in the fluticasone–salmeterol group was 1.03 (95% confidence interval [CI], 0.64 to 1.66), and noninferiority was achieved (P = 0.003). There were no asthma-related deaths; 2 patients in the fluticasone-only group underwent asthmarelated intubation. The risk of a severe asthma exacerbation was 21% lower in the fluticasone–salmeterol group than in the fluticasone-only group (hazard ratio, 0.79; 95% CI, 0.70 to 0.89), with at least one severe asthma exacerbation occurring in 480 of 5834 patients (8%) in the fluticasone–salmeterol group, as compared with 597 of 5845 patients (10%) in the fluticasone-only group (P

Published
2016

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