30 results on '"Dittrich, Sebastian"'
Search Results
2. Modeling of ACTN4-Based Podocytopathy Using Drosophila Nephrocytes
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Odenthal, Johanna, Dittrich, Sebastian, Ludwig, Vivian, Merz, Tim, Reitmeier, Katrin, Reusch, Björn, Höhne, Martin, Cosgun, Zülfü C., Hohenadel, Maximilian, Putnik, Jovana, Göbel, Heike, Rinschen, Markus M., Altmüller, Janine, Koehler, Sybille, Schermer, Bernhard, Benzing, Thomas, Beck, Bodo B., Brinkkötter, Paul T., Habbig, Sandra, and Bartram, Malte P.
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- 2023
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3. Validation of seven risk scores in an independent cohort: the challenge of predicting recurrence after atrial fibrillation ablation
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Filipovic Karlo, Steven Daniel, Sultan Arian, Jan-Hendrik van den Bruck, Wörmann Jonas, Scheurlen Cornelia, Dittrich Sebastian, and Lüker Jakob
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Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Abstract Purpose Several predictive scores for atrial fibrillation (AF) recurrence after AF ablation have been developed. We compared the predictive value of seven previously described risk scores ((CHADS2 and CHA2DS2-VASC, HATCH, APPLE, CAAP-AF, BASE-AF2, MB-LATER) for prediction of AF recurrence risk at 12 months after AF ablation in our patient cohort. Further, we aimed to identify additional variables to predict recurrences after AF ablation. Methods We used data from our digital AF ablation registry to compare the previously published scores in an independent cohort (n = 883, 50.8% with paroxysmal AF). The scores were chosen based on earlier publications and availability of relevant data. Results The BASE-AF2 (AUC 0.630, p
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- 2022
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4. Direct Oral Anticoagulants Versus Vitamin K Antagonists After Mitral Valve Transcatheter Edge-to-Edge Repair in Patients With Atrial Fibrillation: A Single-Center Observational Study.
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Schipper, Jan-Hendrik, Sommer, Anne-Sophie, Nies, Richard Julius, Metze, Clemens, Meertens, Max Maria, Wörmann, Jonas, Dittrich, Sebastian, van den Bruck, Jan-Hendrik, Sultan, Arian, Lüker, Jakob, Steven, Daniel, Hohmann, Christopher, Pfister, Roman, Baldus, Stephan, Eitel, Ingo, Frerker, Christian, and Schmidt, Tobias
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- 2025
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5. Incidence, Implications, and Management of Sense-B-Noise Failure in Subcutaneous Cardioverter-Defibrillator Patients: insights from a large Multicenter Registry
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Wörmann, Jonas, primary, Strik, Marc, additional, Jurisic, Stjepan, additional, Stout, Kara, additional, Elrefai, Mohamed, additional, Becher, Nina, additional, Schaer, Beat, additional, van Stipdonk, Antonius, additional, Srinivasan, Neil T, additional, Ploux, Sylvain, additional, Breitenstein, Alexander, additional, Kron, Jordana, additional, Roberts, Paul R, additional, Toennis, Tobias, additional, Linz, Dominik, additional, Dulai, Rajdip, additional, Hermes-Laufer, Julia, additional, Koneru, Jay, additional, Erküner, Ömer, additional, Dittrich, Sebastian, additional, van den Bruck, Jan-Hendrik, additional, Schipper, Jan-Hendrik, additional, Sultan, Arian, additional, Rosenberger, Kerstin D, additional, Steven, Daniel, additional, and Lüker, Jakob, additional
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- 2024
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6. Occurrence of premature battery depletion in a large multicentre registry of subcutaneous cardioverter-defibrillator patients.
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Wörmann, Jonas, Strik, Marc, Jurisic, Stjepan, Stout, Kara, Elrefai, Mohamed, Becher, Nina, Schaer, Beat, Stipdonk, Antonius van, Srinivasan, Neil T, Ploux, Sylvain, Breitenstein, Alexander, Kron, Jordana, Roberts, Paul R, Toennis, Tobias, Linz, Dominik, Dulai, Rajdip, Hermes-Laufer, Julia, Koneru, Jay, Erküner, Ömer, and Dittrich, Sebastian
- Abstract
Aims Subcutaneous implantable cardioverter-defibrillators (S-ICDs) have become established in preventing sudden cardiac death, with some advantages over transvenous defibrillator systems, including a lower incidence of lead failures. Despite technological advancements, S-ICD carriers may suffer from significant complications, such as premature battery depletion (PBD), that led to an advisory for nearly 40 000 patients. This multicentre study evaluated the incidence of PBD in a large set of S-ICD patients. Methods and results Data from patients implanted with S-ICD models A209 and A219 between October 2012 and July 2023 across nine centres in Europe and the USA were reviewed. Incidence and implications of PBD, defined as clinically observed sudden drop in battery longevity, were analysed and compared to PBD with the definition of battery depletion within 60 months. Prospectively collected clinical data were obtained retrospectively from medical records, device telemetry, and manufacturer reports. This registry is listed on ClinicalTrials.gov (NCT05713708). Of the 1112 S-ICD devices analysed, 547 (49.2%) were equipped with a potentially affected capacitor linked to PBD occurrence, currently under Food and Drug Administration advisory. The median follow-up time for all patients was 46 [inter-quartile range (IQR) 24–63] months. Clinically suspected PBD was observed in 159 (29.1%) of cases, with a median time to generator removal or replacement of 65 (IQR 55–72) months, indicative of significant deviations from expected battery lifespan. Manufacturer confirmation of PBD was made in 91.7% of devices returned for analysis. No cases of PBD were observed in devices that were not under advisory. Conclusion This manufacturer-independent analysis highlights a notable incidence of PBD in patients equipped with S-ICD models under advisory, and the rate of PBD in this study corresponds to the rate currently estimated by the manufacturer. To the best of our knowledge, this provides the largest contemporary peer-reviewed study cohort investigating the actual incidence of PBD in S-ICD patients. These findings emphasize the importance of post-market registries in collaboration between clinicians and the manufacturer to optimize safety and efficacy in S-ICD treatment. [ABSTRACT FROM AUTHOR]
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- 2024
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7. A Multi-layered Quantitative In Vivo Expression Atlas of the Podocyte Unravels Kidney Disease Candidate Genes
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Rinschen, Markus M., Gödel, Markus, Grahammer, Florian, Zschiedrich, Stefan, Helmstädter, Martin, Kretz, Oliver, Zarei, Mostafa, Braun, Daniela A., Dittrich, Sebastian, Pahmeyer, Caroline, Schroder, Patricia, Teetzen, Carolin, Gee, HeonYung, Daouk, Ghaleb, Pohl, Martin, Kuhn, Elisa, Schermer, Bernhard, Küttner, Victoria, Boerries, Melanie, Busch, Hauke, Schiffer, Mario, Bergmann, Carsten, Krüger, Marcus, Hildebrandt, Friedhelm, Dengjel, Joern, Benzing, Thomas, and Huber, Tobias B.
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- 2018
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8. Implementation and first outcomes of a novel standard operating procedure for preprocedural transoesophageal echocardiography screening in course of atrial arrhythmia ablation
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Dittrich, Sebastian, primary, Kece, Fehmi, additional, Scheurlen, Cornelia, additional, van den Bruck, Jan-Hendrik, additional, Filipovic, Karlo, additional, Wörmann, Jonas, additional, Erlhöfer, Susanne, additional, Pavel, Friederike, additional, Schipper, Jan-Hendrik, additional, Sultan, Arian, additional, Lüker, Jakob, additional, and Steven, Daniel, additional
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- 2023
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9. Lakeshore vegetation: More resilient towards human recreation than we think?
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Meyer, Nora, primary, Swiatloch, Anna, additional, Dittrich, Sebastian, additional, and von Oheimb, Goddert, additional
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- 2023
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10. Charakterisierung einer neuen, FSGS-assoziierten ACTN4 Mutation im Podozyten
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Dittrich, Sebastian and Dittrich, Sebastian
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Ein zentraler Baustein für die Funktion der Nieren sind ihre Filtrationseinheiten, die Glomeruli. Hierbei ist der Podozyt – eine hochspezialisierte Epithelzelle - als wesentlicher Strukturgeber von großer Bedeutung. Ein wesentlicher Baustein ist hierbei das podozytäre Zytoskelett, das neben der strukturellen Funktion auch in der Signaltransduktion und der hochdynamischen Zellmotilität eine wichtige Rolle spielt. Im Rahmen dieser Promotionsarbeit erfolgte die Untersuchung und Charakterisierung einer bislang unbekannten de novo Mutation des humanen ACTN4-Gens im Zellkulturmodell des Podozyten. Alpha-Aktinin-4 ist hierbei ein bekannter, entscheidender Baustein und Regulator des podozytären Zytoskeletts. Die hier präsentierten Ergebnisse geben Hinweise darauf, dass die hier untersuchte Punktmutation zu einer Veränderung des Zytoskeletts und der Proliferation der betreffenden Zellen führt. Die Überexpression der Mutante löste in Podozyten im Zellkulturmodell eine DNA-Schadensantwort mit verkürzter Lebensdauer aus. Weiterhin zeigen die Untersuchungen eine deutliche Beeinflussung des Aktin-Zytoskeletts, mit Formierung großer, F-Aktin-positiver Aggregate. Bioinformatik-basierte Prädiktionen lassen auf eine Verringerung der thermodynamischen Stabilität der Mutante durch die Punktmutation schließen. Die vorliegenden Ergebnisse ergänzen Daten zu bereits publizierten Mutationen von ACTN4 hinsichtlich der Beeinflussung des podozytären Zytoskeletts und sprechen dafür, dass diese neue, erstmalig beschriebene Variante tatsächlich krankheitsverursachend ist. Ein neuer Aspekt – auch im Vergleich zu bekannten pathogenen ACTN4 Varianten - ist die Induktion einer DNA-Schadenssignatur mit Absterben der Podozyten bei Überexpression. Ob dies der Effekt einer ausgeprägten Toxizität der Mutante und der entstehenden Aggregate in diesem in vitro Model ist oder ob auch spezifische nukleäre Funktionen von Aktinin-4 im Zellkern hier eine Rolle spielen, kann durch die bislang durchgeführten Experi
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- 2023
11. Dipole Density Guided Catheter Ablation versus Conventional Substrate Modification for Repeat Catheter Ablation of Persistent Atrial Fibrillation.
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Schipper, Jan-Hendrik, Steven, Daniel, Lüker, Jakob, Wörmann, Jonas, van den Bruck, Jan-Hendrik, Filipovic, Karlo, Dittrich, Sebastian, Scheurlen, Cornelia, Erlhöfer, Susanne, Pavel, Friederike, and Sultan, Arian
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ATRIAL fibrillation ,CATHETER ablation ,DENSITY - Abstract
Aims: The optimal ablation strategy for recurrent persistent atrial fibrillation (persAF) after initially successful catheter ablation (CA) remains debatable. Dipole density (DD) guided CA using the AcQMap system has been proven to be feasible and effective in patients with persAF. So far, long-term outcome data for DD-guided CA in patients with recurrence of persAF are sparse. This study sought to assess long-term outcome data in patients undergoing a DD-guided CA for recurrence of persAF after previous CA in comparison to conventional repeat CA. Methods and Results: Patients undergoing DD-guided CA for recurrence of persAF after previous ablation were compared to patients undergoing conventional substrate modification (CSM). A total of 64 patients (32 DD-guided and 32 CSM) were included in this analysis. Procedure duration (DD: 236 ± 61 min; CSM: 198 ± 59 min; p = 0.004) and fluoroscopy time (DD: 36 ± 15 min; CSM: 20 ± 11 min; p = 0.0001) were significantly longer in the DD group. After a long-term median follow-up (FU) of 27 months (interquartile range 12.8–34.3), DD-guided CA was inferior to CSM regarding overall arrhythmia-free survival (DD: 6 patients (19%), CSM: 11 patients (34%); HR 1.47; p = 0.04). Freedom from AF did not differ between both groups (DD: 16 patients (50%); CSM: 18 patients (56%), HR 0.99, p = 0.47). During FU, more patients underwent repeat CA after DD-guided ablation (DD: 16 patients (50%), CSM: 7 patients (22%), p = 0.04). No major complications occurred overall. Conclusions: Dipole density-guided CA is equally safe but associated with longer procedure duration compared to conventional substrate modification for treatment of recurrent persAF after previous CA. Of note, long-term arrhythmia-free survival is significantly worse after DD-guided ablation, and more patients undergo redo procedures. [ABSTRACT FROM AUTHOR]
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- 2024
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12. Lichen substance concentrations in the lichen Hypogymnia physodes are correlated with heavy metal concentrations in the substratum
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Hauck, Markus, Böning, Janina, Jacob, Mascha, Dittrich, Sebastian, Feussner, Ivo, and Leuschner, Christoph
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- 2013
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13. Significance of Over-Mature and Decaying Trees for Carbon Stocks in a Central European Natural Spruce Forest
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Jacob, Mascha, Bade, Claudia, Calvete, Héctor, Dittrich, Sebastian, Leuschner, Christoph, and Hauck, Markus
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- 2013
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14. ERRATUM: Small increase in substratum pH causes the dieback of one of Europe's most common lichens, Lecanora conizaeoides
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Hauck, Markus, Otto, Philipp I., Dittrich, Sebastian, Jacob, Mascha, Bade, Claudia, Dörfler, Inken, and Leuschner, Christoph
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- 2011
15. Small increase in sub-stratum pH causes the dieback of one of Europe's most common lichens, Lecanora conizaeoides
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Hauck, Markus, Otto, Philipp I., Dittrich, Sebastian, Jacob, Mascha, Bade, Claudia, Dörfler, Inken, and Leuschner, Christoph
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- 2011
16. Procedural and outcome impact of obesity in cryoballoon versus radiofrequency pulmonary vein isolation in atrial fibrillation patients
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Scheurlen, Cornelia, van den Bruck, Jan-Hendrik, Filipovic, Karlo, Woermann, Jonas, Arica, Zeynep, Erlhoefer, Susanne, Dittrich, Sebastian, Heijman, Jordi, Lueker, Jakob, Steven, Daniel, Sultan, Arian, Scheurlen, Cornelia, van den Bruck, Jan-Hendrik, Filipovic, Karlo, Woermann, Jonas, Arica, Zeynep, Erlhoefer, Susanne, Dittrich, Sebastian, Heijman, Jordi, Lueker, Jakob, Steven, Daniel, and Sultan, Arian
- Abstract
Purpose Cryoballoon (CB) ablation and radiofrequency (RF) ablation are the most common techniques for pulmonary vein isolation (PVI) in patients with symptomatic atrial fibrillation (AF). An increasing number of patients undergoing PVI are obese. To address the paucity of data on outcomes of CB- vs. RF-based PVI in relation to body mass index (BMI) of AF patients. Methods All patients undergoing de novo PVI between 01/2018 and 08/2019 at University Hospital Cologne were included in this retrospective analysis. Patients of each group (CB-PVI vs. RF-PVI) were analyzed based on their BMI. Hereafter, procedural characteristics and AF recurrence rate were compared regarding different BMI groups. Results A total of 526 patients (62% male, 65 +/- 11 years) underwent successful de novo PVI (320 CB and 206 RF). In obese patients, two differences in procedural characteristics were noted: A significantly increased contrast medium volume in CB group and a lower fluoroscopy dose in RF group: contrast medium: CB 50 [40-80] vs. RF 20 [20-30], p<0.001; fluoroscopy dose: CB 392.4 [197.9-995.9] vs. RF 282.5 [139.8-507.2], p<0.001. The complication rate was equal throughout all BMI groups, regardless of CB or RF usage. For obese patients, a trend toward a higher AF recurrence rate was revealed after RF-PVI as compared to CB-PVI. In line with previous studies, the overall procedure time was significantly shorter with CB-PVI regardless of BMI. Conclusion For obese patients, CB-PVI is similarly safe and effective as RF-PVI. The significantly shorter procedure time for CB-PVI may minimize potential obesity-related complications. However, the lower contrast medium quantity and fluoroscopy dose in RF-PVI must be considered. AF recurrence rates were comparable between CB-PVI and RF-PVI.
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- 2022
17. Modeling of ACTN4-Based Podocytopathy Using Drosophila Nephrocytes
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Odenthal, Johanna, Dittrich, Sebastian, Ludwig, Vivian, Merz, Tim, Reitmeier, Katrin, Reusch, Bjoern, Hoehne, Martin, Cosgun, Zuelfue C., Hohenadel, Maximilian, Putnik, Jovana, Goebel, Heike, Rinschen, Markus M., Altmueller, Janine, Koehler, Sybille, Schermer, Bernhard, Benzing, Thomas, Beck, Bodo B., Brinkkoetter, Paul T., Habbig, Sandra, Bartram, Malte P., Odenthal, Johanna, Dittrich, Sebastian, Ludwig, Vivian, Merz, Tim, Reitmeier, Katrin, Reusch, Bjoern, Hoehne, Martin, Cosgun, Zuelfue C., Hohenadel, Maximilian, Putnik, Jovana, Goebel, Heike, Rinschen, Markus M., Altmueller, Janine, Koehler, Sybille, Schermer, Bernhard, Benzing, Thomas, Beck, Bodo B., Brinkkoetter, Paul T., Habbig, Sandra, and Bartram, Malte P.
- Abstract
Introduction: Genetic disorders are among the most prevalent causes leading to progressive glomerular disease and, ultimately, end-stage renal disease (ESRD) in children and adolescents. Identification of underlying genetic causes is indispensable for targeted treatment strategies and counseling of affected patients and their families. Methods: Here, we report on a boy who presented at 4 years of age with proteinuria and biopsy-proven focal segmental glomerulosclerosis (FSGS) that was temporarily responsive to treatment with ciclo-sporin A. Molecular genetic testing identified a novel mutation in alpha-actinin-4 (p.M240T). We describe a feasible and efficient experimental approach to test its pathogenicity by combining in silico, in vitro, and in vivo analyses. Results: The de novo p.M240T mutation led to decreased alpha-actinin-4 stability as well as protein mislocalization and actin cytoskeleton rearrangements. Transgenic expression of wild-type human alpha-actinin-4 in Drosophila melanogaster nephrocytes was able to ameliorate phenotypes associated with the knockdown of endogenous actinin. In contrast, p.M240T, as well as other established disease variants p.W59R and p.K255E, failed to rescue these phenotypes, underlining the pathogenicity of the novel alpha-actinin-4 variant. Conclusion: Our data highlight that the newly identified alpha-actinin-4 mutation indeed encodes for a disease-causing variant of the protein and promote the Drosophila model as a simple and convenient tool to study monogenic kidney disease in vivo.
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- 2022
18. Non-invasive vagal stimulation for paroxysmal atrial fibrillation: a promising treatment strategy?
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Steven, Daniel, van den Bruck, Jan-Hendrik, Woermann, Jonas, Filipovic, Karlo, Dittrich, Sebastian, Lueker, Jakob, Sultan, Arian, Steven, Daniel, van den Bruck, Jan-Hendrik, Woermann, Jonas, Filipovic, Karlo, Dittrich, Sebastian, Lueker, Jakob, and Sultan, Arian
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Zusammenfassung Autonome Dysbalance kann die Wahrscheinlichkeit fur das Auftreten von paroxysmalem Vorhofflimmern beeinflussen. Fruhere Studien haben gezeigt, dass die Ablation autonomer Ganglien im linken Vorhof Rezidive von Vorhofflimmern reduzieren kann. Die bisherige Therapie von Vorhofflimmern besteht aus wenig effektiven medikamentosen Ansatzen und potenziell mit Risiken behafteten invasiven Verfahren, wie der katheterbasierten Isolation der Pulmonalvenen. Eine einfach durchzufuhrende nicht invasive Stimulation des N. vagus konnte eine mogliche Therapieoption sein. Die Effektivitat dieses Verfahrens ist in einer kurzlich erschienenen randomisierten Arbeit mit einer relativ geringen Anzahl von Patienten untersucht worden. Der vorliegende Artikel gibt einen uberblick uber die Therapie und ordnet den Stellenwert perspektivisch ein. Abstract Autonomic imbalance is a presumed mechanism for increasing the likelihood of paroxysmal atrial fibrillation occurrence. Earlier studies have shown that catheter-based ablation of ganglionated plexi within the left atrium may reduce the probability of atrial fibrillation recurrence. Current therapeutic strategies for atrial fibrillation consist of a modestly efficient medical treatment and invasive ablation with the risk of potential complications. A non-invasive, easily applicable external vagal nerve stimulation may be a therapeutic option. The effectiveness of this strategy was evaluated in a prospective randomized trial with a limited number of patients. The present article discusses this study and relates it to current knowledge in this field.
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- 2021
19. Recovery of Raw Materials from Ceramic Waste Materials for the Refractory Industry
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Seifert, Severin, primary, Dittrich, Sebastian, additional, and Bach, Jürgen, additional
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- 2021
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20. Cryptogamic epiphytes and microhabitat diversity on non-native green ash (Fraxinus pennsylvanica Marsh., Oleaceae) in urban habitats.
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Dittrich, Sebastian, Thiem, Elke, Albrecht, Birte Marie, and von Oheimb, Goddert
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EPIPHYTIC lichens , *ASH (Tree) , *ECOLOGICAL niche , *ORNAMENTAL trees , *EPIPHYTES , *OLEACEAE - Abstract
With the increased planting of non-native trees within urban environments there is a need for investigating the impacts they may have on the indigenous biodiversity. In this study, we explored the diversity of epiphytic lichens and bryophytes as well as the tree-related microhabitats on planted, non-native green ash Fraxinus pennsylvanica and compared it to that of indigenous Fraxinus excelsior and Quercus robur. We conducted sampling on trees of similar growing conditions and size within two cities of eastern Germany (Dresden and Dessau-Roßlau). In our analysis we did not find any significant differences in epiphyte diversity and abundance. By contrast, microhabitat diversity was significantly higher on F. pennsylvanica than on the indigenous tree species, which we attribute to the pioneer character of F. pennsylvanica with faster ageing. Our results underline a low impact of F. pennsylvanica on epiphytic lichen and bryophyte diversity, while indigenous animals might even benefit from the higher diversity and frequency of microhabitats on trees of this species. Therefore, its use as an ornamental tree should not be generally rejected in urban environments. [ABSTRACT FROM AUTHOR]
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- 2021
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21. Effects of forest management intensity on herb layer plant diversity and composition of deciduous forest communities in Northern Germany
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Petzold, Judith, Dittrich, Sebastian, Fichtner, Andreas, Härdtle, Werner, Naumann, Birte, and von Oheimb, Goddert
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deciduous forests ,Ecosystems Research ,forest management intensity ,biodiversity change ,vegetation resurvey ,understorey vegetation - Abstract
Forest management is assumed to significantly affect herb layer species richness and community composition. Thus, the main objective of this study was to assess the effects of a reduction in forest management intensity on herb layer species assemblages in deciduous forests of Northern Germany. We selected forest stands which had been managed according to different management intensities (i.e., single-tree and group selection harvest) up to the year 1994, and which were subject to a low-impact management approach (i.e., single-tree harvest with minimal thinning interventions and the develop-ment of high growing stocks) since then. Unmanaged forest stands were used as a reference for the managed stands. Results from a previous study using vegetation data recorded in 1997 showed that species richness and compositional differences of the herb layer increased significantly with manage-ment intensity. The present study is based on a re-survey of these forest stands after 17 years. We therefore hypothesized that – as a result of the less intensive the forest management – the herb layer in both types of managed stands became more similar to that of the unmanaged stands over time. Specifi-cally, we expected the changes in the stands with former group selection harvest to be stronger than those of the stands with former single-tree selection harvest. We found that herb layer species richness and cover decreased considerably over time, and that these changes were most pronounced in stands with the formerly more intensive management (i.e., former group selection harvest). Detailed analyses of species composition and species groups of the herb layer revealed that only a few differences re-mained in the managed stands when compared to the unmanaged stands. These differences are suggest-ed to be related to previous soil disturbances in synergy with canopy openings. Our results suggest that a minimal intervention single-tree selection harvest system may have a low impact on the typical forest herb layer communities, and that a shift to low-intensity management may lead to a recovery of the plant communities over time even in formerly more intensively managed stands. Forest management is assumed to significantly affect herb layer species richness and community composition. Thus, the main objective of this study was to assess the effects of a reduction in forest management intensity on herb layer species assemblages in deciduous forests of Northern Germany. We selected forest stands which had been managed according to different management intensities (i.e., single-tree and group selection harvest) up to the year 1994, and which were subject to a low-impact management approach (i.e., single-tree harvest with minimal thinning interventions and the development of high growing stocks) since then. Unmanaged forest stands were used as a reference for the managed stands. Results from a previous study using vegetation data recorded in 1997 showed that species richness and compositional differences of the herb layer increased significantly with management intensity. The present study is based on a re-survey of these forest stands after 17 years. We therefore hypothesized that as a result of the less intensive the forest management - the herb layer in both types of managed stands became more similar to that of the unmanaged stands over time. Specifically, we expected the changes in the stands with former group selection harvest to be stronger than those of the stands with former single-tree selection harvest. We found that herb layer species richness and cover decreased considerably over time, and that these changes were most pronounced in stands with the formerly more intensive management (i.e., former group selection harvest). Detailed analyses of species composition and species groups of the herb layer revealed that only a few differences remained in the managed stands when compared to the unmanaged stands. These differences are suggested to be related to previous soil disturbances in synergy with canopy openings. Our results suggest that a minimal intervention single-tree selection harvest system may have a low impact on the typical forest herb layer communities, and that a shift to low-intensity management may lead to a recovery of the plant communities over time even in formerly more intensively managed stands.
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- 2018
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22. Quantification of molecular heterogeneity in kidney tissue by targeted proteomics
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Hoyer, K. Johanna R., Dittrich, Sebastian, Bartram, Malte P., Rinschen, Markus M., Hoyer, K. Johanna R., Dittrich, Sebastian, Bartram, Malte P., and Rinschen, Markus M.
- Abstract
Renal diseases are driven by alterations in the entity of proteins within the kidney, at the level of single cells, nephron subunits (such as glomerulus and tubule), tissues and body fluids. Histologically, kidney diseases are extremely heterogeneous. Mass-spectrometry based proteomics provides a unique opportunity to interrogate heterogeneity and dynamics of various proteome layers within the kidney to better understand physiology and pathophysiology, and to translate signaling networks into therapies. Yet, the success of this endeavor will largely depend on improving proteomic data acquisition methods toward increased reproducibility. Here, we provide an overview of targeted proteomics studies in renal tissue and their insights into major renal diseases such as diabetic nephropathy, acute kidney injury and chronic kidney disease. The technical approaches currently include antibody-based and mass spectrometry based approaches, range from single-cells to single-nephrons to bulk tissue proteomic acquisitions, and are applied to physiological studies and translational approaches in biomarker discovery. Within this context, we identify key challenges in proteomics of kidney biopsies. We also suggest that novel models of translational nephrology have increased need for targeted acquisition of proteomics data with focus on primary urinary cells, organoids and induced renal epithelial cells (IRECs). In conclusion, targeted proteomics will be very beneficial to identify heterogenic disease mechanisms that drive renal disease and further emerge as an important tool in translational kidney research. Significance: Improved targeted proteomics technologies will be an important cornerstone of renal systems medicine in order to identify and tackle the heterogenic disease mechanisms driving renal disease.
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- 2019
23. Impact of forest fires on the long-term dynamics of near-natural Scots pine forests (Leucobryo-Pinetum) in Saxon Switzerland National Park (Saxony, Germany)
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Dittrich, Sebastian, Schmiedel, Doreen, Laupichler, Benjamin, Wagner, Frank, and von Oheimb, Goddert
- Subjects
forest dynamics ,ddc:580 ,Pinus sylvestris ,sh85015976 Botany ,permanent observation plots - Abstract
Verglichen mit Laubwaldgesellschaften sind Langzeitstudien über Waldkiefern-Bestände (Pinus sylvestris L.) in Mitteleuropa selten und die Sukzessionsdynamik von Kiefernwäldern wurden in dieser Region bisher kaum untersucht. Obwohl es sich um den am stärksten von Feuern betroffenen Waldtyp in Mitteleuropa handelt, liegen lediglich wenige Daten zu den Auswirkungen von Bränden auf die Vegetation von mitteleuropäischen Kiefernwäldern vor. Außerdem sind Kiefernwälder in besonders hohem Maße von Eutrophierung betroffen, die starke Veränderungen in der Vegetation verursachen können. In der vorliegenden Studie wurden naturnahe, waldbrandbeeinflusste Kiefernwälder (Leucobryo-Pinetum) im Nationalpark Sächsische Schweiz (Sachsen, Deutschland) untersucht. Dauerbeobachtungsflächen wurden mit bis zu vier Wiederholungen von Vegetationsaufnahmen seit 1963 untersucht. Gemäß den einzelnen Waldbrandereignissen und dem Jahr der Flächeneinrichtung wurden drei Zeitreihen analysiert. (A: 1963-2012, Feuer: 1948/1953); B: 2002-2014, Feuer: 1993; C: 2002-2014, Feuer: 2000), Hierbei wurden unerwartet geringe Veränderungen der Pflanzendiversität und des Artenspektrums der Vegetation gefunden. Nur wenige Arten wurden kurzzeitig durch Waldbrände gefördert, und lediglich einzelne Arten zeigten signifikante Veränderungen in ihren Deckungsgraden in Abhängigkeit vom Waldbrandereignis. Nitrophyten fehlten weitgehend. Offenbar liegen die lokalen Stickstoff-Depositionsraten noch deutlich unter den für einen Vegetationswandel kritischen Werten. Verglichen mit Kiefernforsten und durch traditionelle Nutzung entstandenen Kiefernwäldern stellen naturnahe Bestände des Leucobryo-Pinetum einen relativ stabilen Waldtyp dar, der nur wenig von Waldbränden beeinflusst wird und langfristig nur einer trägen Sukzession unterliegt. Compared to deciduous forest associations, long-term investigations of Scots pine (Pinus sylvestris L.) forests in Central Europe are scarce and their succession dynamics are not well studied. Although being the most fire-prone forest type in Central Europe, there is also a lack of data on the long-term effects of forest fires on the vegetation of Central European Scots Pine forests. Additionally, pine stands are highly vulnerable to eutrophication, strongly altering vegetation. Therefore, we studied near-natural, fire-affected Scots pine forests (Leucobryo-Pinetum) within Saxon Switzerland National Park (Saxony federal state, Germany) by permanent observation plots. Plots where surveyed by vegeta-tion relevés repeated up to four times. Based on the date of the relevant fire events and the year of plot establishment, we analysed three time series (A: 1963–2012, fire 1948/1953); B: 2002–2014, fire: 1993; C: 2002–2014, fire: 2000). Unexpectedly, we found low variation in plant diversity and a low species turnover across the time series. Only few species where propagated by the forest fire events in the short run, few species showed significant cover variations depending on the time passed since the forest fire. Nitrophytic species where nearly absent. The low eutrophication signal in the vegetation is attributed to nitrogen deposition rates below critical rates for species turnover. Compared to Scots pine plantations and Scots pine forests originating from extensive management, near natural stands of the Leucobryo-Pinetum appear as a relatively stable forest type, which is only shortly affected by local forest fires and underlies stagnant succession dynamics in the long run.
- Published
- 2016
24. Quantitative Phasenentwicklung kristalliner, nano-kristalliner und amorpher Phasen während der Hydratation von Portlandzement-Flugasche Systemen
- Author
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Dittrich, Sebastian
- Subjects
cement ,fly ash ,ddc:550 ,Naturwissenschaftliche Fakultät - Abstract
Ambitious efforts driven by political and environmental considerations to reduce carbon dioxide emission are currently present, amongst other branches in the construction material industry as well. One possible solution concentrates on the replacement of cement by supplementary cementitious materials like fly ash or granulated blast furnace slag. Due to its high amorphous phase content and the related reactivity potential fly ash seems well suited for being used in cement or concrete. Unfortunately fly ash shows a very slow reaction leading, compared to a neat cement sample to a retardation of the hydration process in general. The reaction mechanism and the influence of fly ash on the early hydration reaction of cement in particular are of great importance in order to enable an efficient use of fly ash in cementitious materials. In this thesis a siliceous fly ash from a coal combustion plant in Germany was used to replace 50 wt.% of cement in order to investigate the influence on the early hydration cement. Of special interest were the development and the quantification of phases being nano-crystalline or even amorphous. In order to follow the hydration in-situ XRD analysis and heat flow calorimetry was used. To account for effects related to the sole physical presence of particle reference samples of cement blended with 50 wt.% quartz powder were prepared as well. In a first step a quantification technique was successfully implemented enabling the determination of absolute phase quantities in order to quantify amorphous phase content. This so called G-factor method was developed further, making a tracking of nano-crystalline phases like C-S-H during the hydration possible. Even the direct quantification of the fly ash glass in dry samples is possible. However it also turned out that a hydrating fly ash – cement sample appears too complex at the moment to allow a selective quantification of all the amorphous phases present. This especially pertains to the very slow reacting fly ash glass. Despite the slow reaction of fly ash a clear influence on the reactions of the cement can be found within the first 2 days of hydration. The addition of fly ash leads to a retardation of both the aluminate and the silicate reaction, representing the main cement reactions. This effect is stronger if the particle size of the fly ash added is decreased. One explanation for the retardation is the adsorption of Ca2+ ions to the surface of fly ash particles leading to an insufficient amount of available calcium ions. Additional SO3 provided by the fly ash promotes the retardation of the aluminate reaction and therefore is strongly dependent on the fly ash chemistry. A blending with quartz powder triggers the cement reactions by offering suitable nucleation sites. In further investigations it was proofed, that these findings are valid for technical and laboratory prepared cements as well. By tracking the pozzolanic reaction of the fly ash via the quantification of portlandite it becomes apparent that the active reaction of fly ash starts within the first 7 days of iii hydration. After 7 days one can find reaction edges due to dissolution around fly ash particles. As the availability of calcium ions at the slowly dissolving fly ash particles is hindered by the dense hydration products of the cement reaction, the formation of aluminum rich C-(A)-S-H gel takes place. This gel is present as an inner product (replacing the solid fly ash particle) showing a low density and a high water amount as scanning electron microscopy (SEM) investigations proofed. Die Senkung von CO2 Emissionen im industriellen Bereich ist ein vieldiskutiertes Thema und führt, wie in vielen anderen Industriezweigen, in der Baubranche zu neuen Ansätzen um den vorgegebenen Auflagen gerecht zu werden. Neben Bemühungen zur Einsparung von fossilen Brennstoffen kann auch die Reduzierung der Mengen an hergestellten Zement zur Reduktion von CO2 beitragen. Dies geschieht im Wesentlichen durch die Verwendung von Komposit-Zementen, in welchen Teile des Zements durch andere (latent) hydraulisch aktive Materialien wie Flugasche oder Hüttensand ersetzt werden. Flugasche erscheint auf Grund des hohen Glasanteils als geeignetes Material für den Einsatz in Zement oder Beton. Jedoch bewirkt die Zugabe von Flugasche auf Grund der langsamen Reaktionsgeschwindigkeit in Bezug auf den Zement einen verzögerten Festigkeitsaufbau. Die Ursache und die Art und Weise wie die frühen Zementreaktionen durch Flugasche beeinflusst werden sind von großer Bedeutung um einen effektiven Einsatz von Flugasche in zementären Bindemitteln zu ermöglichen. In der vorliegenden Arbeit wurden 50 Ma.% von Zement durch eine silikatreiche Flugasche aus einem Steinkohlekraftwerk ersetzt und deren Einfluss auf die Hydratation untersucht. Durch den Einsatz von Wärmeflusskalorimetrie und in-situ Röntgenbeugung wurde die Entwicklung und Quantifizierung nano-kristalliner und amorpher Phasen ermöglicht. Um Effekte bedingt durch die reine physikalische Präsenz von Partikeln separieren zu können wurden Referenzproben untersucht, in welchen statt Flugasche Quarz zum Einsatz kam. Zunächst wurde eine Quantifizierungsstrategie entwickelt um den amorphen Phasengehalt einer Probe direkt zu bestimmen. Diese so genannte G-Faktor Methode wurde dann im Speziellen weiterentwickelt um die Quantifizierung von C-S-H und Flugascheglas in hydratisierenden Proben zu ermöglichen. Die hohe Komplexität hydratisierender Flugasche-Zement Gemische mit bis zu 5 verschiedenen amorphen Komponenten erlaubt eine direkte Quantifizierung des Flugasche-Glas bisher nicht. Grund dafür ist auch die sehr langsame Reaktionszeit des Glases. Trotz der langsamen aktiven Reaktion der Flugasche kann eine deutliche Beeinflussung der Zementreaktionen innerhalb der ersten zwei Tage beobachtet werden. Sowohl die Silikat- als auch die Aluminatreaktion des Zements treten bei Anwesenheit von Flugasche verzögert auf. Dieser Effekt ist deutlicher ausgeprägt wenn die Partikelgröße der Flugasche verringert wird. Eine Erklärung für die verzögernde Wirkung kann durch die Adsorption von Ca2+ Ionen aus der Porenlösung an die Oberflächen der Flugaschepartikel erklärt werden. Diese Ionen stehen dem Zement damit nicht mehr zu Verfügung und müssen erst wieder nachgelöst werden. Zusätzlich bewirkt der leichtlösliche Sulfatgehalt der Flugasche eine verzögerte Auflösung von C3A und bremst damit die Aluminatreaktion. Die Zugabe von Quarz bewirkt in Abhängigkeit der Partikelgröße eine beschleunigte Zementreaktion durch die zusätzlich zu Verfügung stehenden Keimbildungsplätze. Diese Beobachtungen treten sowohl in technisch produzierten Zementen als auch in synthetisch hergestellten Laborzementen auf. v Die puzzolanische Reaktion der Flugasche kann auch über die Detektion des Portlandit Gehaltes erfolgen. Hieraus wird ersichtlich, dass die Reaktion der Flugasche innerhalb der ersten 7 Tage beginnt. Danach kann eine langsame Auflösung einzelner Flugaschepartikel mittels Rasterelektronenmikroskopie (REM) beobachtet werden. Auf Grund der zu dieser Zeit bereits bestehenden dichten Hydratphasensäume aus der Zementhydratation können Kalziumionen nur sehr langsam und unzureichend zu den Flugaschepartikeln vordringen. Daher bildet sich an den Reaktionssäumen der Flugaschen ein aluminatreiches C-(A)-S-H Gel welches als inneres Produkt bezeichnet werden kann. Diese Gelphase zeichnet sich durch eine geringe Dichte und einen hohen Wassergehalt aus.
- Published
- 2015
25. Auswirkungen von Waldbränden auf die Langzeitdynamik naturnaher Kiefernwälder (Leucobryo-Pinetum) im Nationalpark Sächsische Schweiz (Sachsen, Deutschland)
- Author
-
Dittrich, Sebastian, Schmiedel, Doreen, Laupichler, Benjamin, Wagner, Frank, Oheimb, Goddert von, Dittrich, Sebastian, Schmiedel, Doreen, Laupichler, Benjamin, Wagner, Frank, and Oheimb, Goddert von
- Abstract
Verglichen mit Laubwaldgesellschaften sind Langzeitstudien über Waldkiefern-Bestände (Pinus sylvestris L.) in Mitteleuropa selten und die Sukzessionsdynamik von Kiefernwäldern wurden in dieser Region bisher kaum untersucht. Obwohl es sich um den am stärksten von Feuern betroffenen Waldtyp in Mitteleuropa handelt, liegen lediglich wenige Daten zu den Auswirkungen von Bränden auf die Vegetation von mitteleuropäischen Kiefernwäldern vor. Außerdem sind Kiefernwälder in besonders hohem Maße von Eutrophierung betroffen, die starke Veränderungen in der Vegetation verursachen können. In der vorliegenden Studie wurden naturnahe, waldbrandbeeinflusste Kiefernwälder (Leucobryo-Pinetum) im Nationalpark Sächsische Schweiz (Sachsen, Deutschland) untersucht. Dauerbeobachtungsflächen wurden mit bis zu vier Wiederholungen von Vegetationsaufnahmen seit 1963 untersucht. Gemäß den einzelnen Waldbrandereignissen und dem Jahr der Flächeneinrichtung wurden drei Zeitreihen analysiert. (A: 1963-2012, Feuer: 1948/1953); B: 2002-2014, Feuer: 1993; C: 2002-2014, Feuer: 2000), Hierbei wurden unerwartet geringe Veränderungen der Pflanzendiversität und des Artenspektrums der Vegetation gefunden. Nur wenige Arten wurden kurzzeitig durch Waldbrände gefördert, und lediglich einzelne Arten zeigten signifikante Veränderungen in ihren Deckungsgraden in Abhängigkeit vom Waldbrandereignis. Nitrophyten fehlten weitgehend. Offenbar liegen die lokalen Stickstoff-Depositionsraten noch deutlich unter den für einen Vegetationswandel kritischen Werten. Verglichen mit Kiefernforsten und durch traditionelle Nutzung entstandenen Kiefernwäldern stellen naturnahe Bestände des Leucobryo-Pinetum einen relativ stabilen Waldtyp dar, der nur wenig von Waldbränden beeinflusst wird und langfristig nur einer trägen Sukzession unterliegt., Compared to deciduous forest associations, long-term investigations of Scots pine (Pinus sylvestris L.) forests in Central Europe are scarce and their succession dynamics are not well studied. Although being the most fire-prone forest type in Central Europe, there is also a lack of data on the long-term effects of forest fires on the vegetation of Central European Scots Pine forests. Additionally, pine stands are highly vulnerable to eutrophication, strongly altering vegetation. Therefore, we studied near-natural, fire-affected Scots pine forests (Leucobryo-Pinetum) within Saxon Switzerland National Park (Saxony federal state, Germany) by permanent observation plots. Plots where surveyed by vegeta-tion relevés repeated up to four times. Based on the date of the relevant fire events and the year of plot establishment, we analysed three time series (A: 1963–2012, fire 1948/1953); B: 2002–2014, fire: 1993; C: 2002–2014, fire: 2000). Unexpectedly, we found low variation in plant diversity and a low species turnover across the time series. Only few species where propagated by the forest fire events in the short run, few species showed significant cover variations depending on the time passed since the forest fire. Nitrophytic species where nearly absent. The low eutrophication signal in the vegetation is attributed to nitrogen deposition rates below critical rates for species turnover. Compared to Scots pine plantations and Scots pine forests originating from extensive management, near natural stands of the Leucobryo-Pinetum appear as a relatively stable forest type, which is only shortly affected by local forest fires and underlies stagnant succession dynamics in the long run.
- Published
- 2016
26. A Multi-layered Quantitative In VivoExpression Atlas of the Podocyte Unravels Kidney Disease Candidate Genes
- Author
-
Rinschen, Markus M., Gödel, Markus, Grahammer, Florian, Zschiedrich, Stefan, Helmstädter, Martin, Kretz, Oliver, Zarei, Mostafa, Braun, Daniela A., Dittrich, Sebastian, Pahmeyer, Caroline, Schroder, Patricia, Teetzen, Carolin, Gee, HeonYung, Daouk, Ghaleb, Pohl, Martin, Kuhn, Elisa, Schermer, Bernhard, Küttner, Victoria, Boerries, Melanie, Busch, Hauke, Schiffer, Mario, Bergmann, Carsten, Krüger, Marcus, Hildebrandt, Friedhelm, Dengjel, Joern, Benzing, Thomas, and Huber, Tobias B.
- Abstract
Damage to and loss of glomerular podocytes has been identified as the culprit lesion in progressive kidney diseases. Here, we combine mass spectrometry-based proteomics with mRNA sequencing, bioinformatics, and hypothesis-driven studies to provide a comprehensive and quantitative map of mammalian podocytes that identifies unanticipated signaling pathways. Comparison of the in vivodatasets with proteomics data from podocyte cell cultures showed a limited value of available cell culture models. Moreover, in vivostable isotope labeling by amino acids uncovered surprisingly rapid synthesis of mitochondrial proteins under steady-state conditions that was perturbed under autophagy-deficient, disease-susceptible conditions. Integration of acquired omics dimensions suggested FARP1 as a candidate essential for podocyte function, which could be substantiated by genetic analysis in humans and knockdown experiments in zebrafish. This work exemplifies how the integration of multi-omics datasets can identify a framework of cell-type-specific features relevant for organ health and disease.
- Published
- 2018
- Full Text
- View/download PDF
27. Significance of Over-Mature and Decaying Trees for Carbon Stocks in a Central European Natural Spruce Forest
- Author
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Jacob, Mascha, primary, Bade, Claudia, additional, Calvete, Héctor, additional, Dittrich, Sebastian, additional, Leuschner, Christoph, additional, and Hauck, Markus, additional
- Published
- 2012
- Full Text
- View/download PDF
28. Small increase in substratum pH causes the dieback of one of Europe's most common lichens, Lecanora conizaeoides
- Author
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Hauck, Markus, primary, Otto, Philipp I., additional, Dittrich, Sebastian, additional, Jacob, Mascha, additional, Bade, Claudia, additional, Dörfler, Inken, additional, and Leuschner, Christoph, additional
- Published
- 2011
- Full Text
- View/download PDF
29. A multi-layered quantitative in vivo expression atlas of the podocyte unravels kidney disease candidate genes
- Author
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Rinschen, Markus M., Gödel, Markus, Grahammer, Florian, Zschiedrich, Stefan, Helmstädter, Martin, Kretz, Oliver, Zarei, Mostafa, Braun, Daniela A., Dittrich, Sebastian, Pahmeyer, Caroline, Schroder, Patricia, Teetzen, Carolin, Gee, HeonYung, Daouk, Ghaleb, Pohl, Martin, Kuhn, Elisa, Schermer, Bernhard, Küttner, Victoria, Boerries, Melanie, Busch, Hauke, Schiffer, Mario, Bergmann, Carsten, Krüger, Marcus, Hildebrandt, Friedhelm, Dengjel, Jörn, Benzing, Thomas, Huber, Tobias B., Rinschen, Markus M., Gödel, Markus, Grahammer, Florian, Zschiedrich, Stefan, Helmstädter, Martin, Kretz, Oliver, Zarei, Mostafa, Braun, Daniela A., Dittrich, Sebastian, Pahmeyer, Caroline, Schroder, Patricia, Teetzen, Carolin, Gee, HeonYung, Daouk, Ghaleb, Pohl, Martin, Kuhn, Elisa, Schermer, Bernhard, Küttner, Victoria, Boerries, Melanie, Busch, Hauke, Schiffer, Mario, Bergmann, Carsten, Krüger, Marcus, Hildebrandt, Friedhelm, Dengjel, Jörn, Benzing, Thomas, and Huber, Tobias B.
- Abstract
Damage to and loss of glomerular podocytes has been identified as the culprit lesion in progressive kidney diseases. Here, we combine mass spectrometry-based proteomics with mRNA sequencing, bioinformatics, and hypothesis-driven studies to provide a comprehensive and quantitative map of mammalian podocytes that identifies unanticipated signaling pathways. Comparison of the in vivo datasets with proteomics data from podocyte cell cultures showed a limited value of available cell culture models. Moreover, in vivo stable isotope labeling by amino acids uncovered surprisingly rapid synthesis of mitochondrial proteins under steady-state conditions that was perturbed under autophagy-deficient, disease-susceptible conditions. Integration of acquired omics dimensions suggested FARP1 as a candidate essential for podocyte function, which could be substantiated by genetic analysis in humans and knockdown experiments in zebrafish. This work exemplifies how the integration of multi-omics datasets can identify a framework of cell-type-specific features relevant for organ health and disease.
30. Occurrence of premature battery depletion in a large multicentre registry of subcutaneous cardioverter-defibrillator patients.
- Author
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Wörmann J, Strik M, Jurisic S, Stout K, Elrefai M, Becher N, Schaer B, van Stipdonk A, Srinivasan NT, Ploux S, Breitenstein A, Kron J, Roberts PR, Toennis T, Linz D, Dulai R, Hermes-Laufer J, Koneru J, Erküner Ö, Dittrich S, van den Bruck JH, Schipper JH, Sultan A, Rosenberger KD, Steven D, and Lüker J
- Subjects
- Humans, Male, Female, Middle Aged, Retrospective Studies, Aged, United States epidemiology, Death, Sudden, Cardiac prevention & control, Death, Sudden, Cardiac epidemiology, Europe epidemiology, Electric Countershock instrumentation, Electric Countershock adverse effects, Equipment Failure statistics & numerical data, Time Factors, Equipment Failure Analysis statistics & numerical data, Adult, Defibrillators, Implantable, Registries, Electric Power Supplies
- Abstract
Aims: Subcutaneous implantable cardioverter-defibrillators (S-ICDs) have become established in preventing sudden cardiac death, with some advantages over transvenous defibrillator systems, including a lower incidence of lead failures. Despite technological advancements, S-ICD carriers may suffer from significant complications, such as premature battery depletion (PBD), that led to an advisory for nearly 40 000 patients. This multicentre study evaluated the incidence of PBD in a large set of S-ICD patients., Methods and Results: Data from patients implanted with S-ICD models A209 and A219 between October 2012 and July 2023 across nine centres in Europe and the USA were reviewed. Incidence and implications of PBD, defined as clinically observed sudden drop in battery longevity, were analysed and compared to PBD with the definition of battery depletion within 60 months. Prospectively collected clinical data were obtained retrospectively from medical records, device telemetry, and manufacturer reports. This registry is listed on ClinicalTrials.gov (NCT05713708). Of the 1112 S-ICD devices analysed, 547 (49.2%) were equipped with a potentially affected capacitor linked to PBD occurrence, currently under Food and Drug Administration advisory. The median follow-up time for all patients was 46 [inter-quartile range (IQR) 24-63] months. Clinically suspected PBD was observed in 159 (29.1%) of cases, with a median time to generator removal or replacement of 65 (IQR 55-72) months, indicative of significant deviations from expected battery lifespan. Manufacturer confirmation of PBD was made in 91.7% of devices returned for analysis. No cases of PBD were observed in devices that were not under advisory., Conclusion: This manufacturer-independent analysis highlights a notable incidence of PBD in patients equipped with S-ICD models under advisory, and the rate of PBD in this study corresponds to the rate currently estimated by the manufacturer. To the best of our knowledge, this provides the largest contemporary peer-reviewed study cohort investigating the actual incidence of PBD in S-ICD patients. These findings emphasize the importance of post-market registries in collaboration between clinicians and the manufacturer to optimize safety and efficacy in S-ICD treatment., Competing Interests: Conflict of interest: J.W. reports having received lecture fees from Abbott and Boston Scientific and educational fees from Boston Scientific and Johnson & Johnson. J.L. and D.S. report having received lecture fees from Johnson & Johnson, Abbott, and Boston Scientific. A.S. reports having received lecture fees from Medtronic, Boston Scientific, Abbott, and Johnson & Johnson. J.H.-L. reports having received educational fees from Boston Scientific, Medtronic, Abbott, and Biotronik and speaker fees from Abbott. N.T.S. reports having received research funding from Abbott. N.B. reports having received an educational grant from Biotronik and speaker fees from Medtronic and Abbott, all outside this submitted work. A.B. reports having received consultant and/or speaker fees from Abbott, Bayer Healthcare, Biosense Webster, Biotronik, Boston Scientific, Bristol-Myers Squibb, Cook Medical, Daiichi Sankyo, Medtronic, Pfizer, and Spectranetics/Philips. J.S. reports having received educational fees from Boston Scientific and Johnson & Johnson and lecture fees from Abbott. All other authors report nothing to declare., (© The Author(s) 2024. Published by Oxford University Press on behalf of the European Society of Cardiology.)
- Published
- 2024
- Full Text
- View/download PDF
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