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Lawrence Chukwudi Nwabudike,1 Ana Maria Oproiu,2,3 Ioana Mihaela Dogaru,2,3,* Mariana Costache,3,4,* Alin Laurentiu Tatu5– 7 1Outpatient Dermatology, N. Paulescu National Institute of Bucharest, Bucharest, Romania; 2Department of Plastic Surgery, Emergency University Hospital, Bucharest, Romania; 3Carol Davila University of Medicine and Pharmacy, Bucharest, Romania; 4Department of Pathology, Emergency University Hospital, Bucharest, Romania; 5Clinical Medicine Department, Faculty of Medicine and Pharmacy, Dunarea de Jos University of Galati, Galati, Romania; 6Dermatology Department, St Parascheva Clinical Hospital of Infectious Diseases, Galati, Romania; 7Multidisciplinary Integrated Center for Dermatologic Interface Research (MIC-DIR), Galati, Romania*These authors contributed equally to this workCorrespondence: Lawrence Chukwudi Nwabudike, N. Paulescu Institute of Bucharest, 5-7 Ion Movila Street, Sector 2, Bucharest, Romania, Email Chukwudi.nwabudike@live.com Ana Maria Oproiu, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania, Email anamariaoproiu@gmail.comAbstract: Spontaneous regression of malignant melanoma was first reported over a century ago. Clinically, areas of blue or grey colouration in lesions may be indicative of regression. Dermoscopy is a very useful tool for diagnosing regression. An important criterion is the blue-white scar. About 10– 35% of excised melanomas show features of regression histopathologically. We present a case of regressing melanoma, with clinical and dermoscopic features suggesting a collision tumour, diagnosed histopathologically. This case might improve our knowledge of the potential clinical manifestations, and the biology, of regressing melanoma.Keywords: regressing melanoma, collision lesion, blue-white scar, pepper-like granules, milia-like cysts, pseudofollicular openings

Lawrence Chukwudi Nwabudike,1,* Ana Maria Oproiu,2,3,* Ioana Mihaela Dogaru,2,3,* Mariana Costache,2,4,* Cristian Onisor,5 Alin Laurentiu Tatu5– 7 1N. Paulescu National Institute of Diabetes, Bucharest, Romania; 2Carol Davila University of Medicine and Pharmacy, Bucharest, Romania; 3Department of Plastic Surgery, Emergency University Hospital, Bucharest, Romania; 4Department of Pathology, Emergency University Hospital, Bucharest, Romania; 5Clinical Medical Department, Faculty of Medicine and Pharmacy, Dunarea de Jos University of Galati, Galati, 800008, Romania; 6Dermatology Department, ’Sf. Cuvioasa Parascheva’ Clinical Hospital of Infectious Diseases, Galati, Romania; 7Multidisciplinary Integrative Center for Dermatologic Interface Research MIC-DIR, Galati, Romania*These authors contributed equally to this workCorrespondence: Lawrence Chukwudi NwabudikeN. Paulescu National Institute of Diabetes, 5-7 Ion Movila Street, Sector 2, Bucharest, RomaniaEmail Chukwudi.nwabudike@live.comCristian OnisorDunarea de Jos University of Galati, Faculty of Medicine and Pharmacy, 47 Domneasca Str., Galati, 800008, RomaniaEmail cristi.onisor@gmail.comAbstract: Malignant melanoma is a deadly form of skin cancer, and prompt diagnosis is a key factor in providing adequate, life-saving therapy. A 75-year-old man, with long-standing type 2 diabetes mellitus, presented with a 2- to 3-year history of right heel ulcer. He had received various therapies for a diagnosis of diabetic foot ulcer, to no avail. Physical examination showed a black, fungating ulcerated lesion on his right heel, with minimal bleeding. No inguinal lymphadenopathy was palpated. A biopsy was done, which revealed BRAF-negative malignant melanoma, with a vertical growth phase, Breslow 3.1 mm, ulceration, 11 mitoses/mm2, Clark level IV, no lymphatic or vascular invasion observed. Right inguinal lymph node sampling suggested no involvement, but PET-CT suggested pulmonary, right inguinal lymph node and bone involvement. The patient was referred to the oncologists. Written informed consent for publication was given by the patient. Diabetic foot ulcers are a frequently encountered, but serious complication of diabetes mellitus. Delayed healing is often seen, despite adequate therapy. The differential diagnosis of diabetic foot ulcers is vast and includes neoplasia. When a foot ulcer fails to heal, other differential diagnoses must be considered, in order for the patient to receive adequate therapy. Here specialist consultations, including dermatology consultations, could improve chances of delivering the right therapy promptly. This is a factor underlying the emphasis on a multidisciplinary approach to foot ulcer therapy. Our presentation – reported according to the CARE guidelines – also illustrates the fact that failure to reach a timely diagnosis may deny the patient the opportunity to receive adequate treatment. In such cases, “delayed therapy becomes denied (or failed) therapy”, paraphrasing the old adage “Justice delayed is justice denied”.Keywords: malignant ulcer, case report, acral malignant melanoma, diabetic foot ulcer, type 2 diabetes mellitus, delayed therapy