122 results on '"Doggett J"'
Search Results
2. Don't Dream It, B It: DEI policies add up to belonging
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Doggett, J. Maija
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Workplace multiculturalism -- Management -- Forecasts and trends ,Company business management ,Market trend/market analysis ,Business ,Business, regional - Abstract
By now, you've seen the initialism DEI, and you know that the letter 'D' stands for diversity, the letter 'E' stands for equity, and the letter 'I' stands for inclusion. [...]
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- 2023
3. Comparative efficacy of buparvaquone and imidocarb in inhibiting the in vitro growth of Babesia bovis
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Cardillo, Natalia M., primary, Lacy, Paul A., additional, Villarino, Nicolas F., additional, Doggett, J. Stone, additional, Riscoe, Michael K., additional, Bastos, Reginaldo G., additional, Laughery, Jacob M., additional, Ueti, Massaro W., additional, and Suarez, Carlos E., additional
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- 2024
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4. Endochin-like quinolones (ELQs) and bumped kinase inhibitors (BKIs): Synergistic and additive effects of combined treatments against Neospora caninum infection in vitro and in vivo
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Anghel, Nicoleta, Imhof, Dennis, Winzer, Pablo, Balmer, Vreni, Ramseier, Jessica, Haenggeli, Kai, Choi, Ryan, Hulverson, Matthew A., Whitman, Grant R., Arnold, Samuel L.M., Ojo, Kayode K., Van Voorhis, Wesley C., Doggett, J. Stone, Ortega-Mora, Luis M., and Hemphill, Andrew
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- 2021
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5. Verifying Sincerity: A human resources perspective on vaccine mandates
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Doggett, J. Maija
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United States. Occupational Safety and Health Administration ,Vaccines ,Business ,Business, regional - Abstract
You can say I am a card-carrying, dyed-in-the-wool, devoted human resources professional. I got my bachelor's degree in business management, with an emphasis in human resource management, from UAA in [...]
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- 2022
6. In vitro activity, safety and in vivo efficacy of the novel bumped kinase inhibitor BKI-1748 in non-pregnant and pregnant mice experimentally infected with Neospora caninum tachyzoites and Toxoplasma gondii oocysts
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Imhof, Dennis, Anghel, Nicoleta, Winzer, Pablo, Balmer, Vreni, Ramseier, Jessica, Hänggeli, Kai, Choi, Ryan, Hulverson, Matthew A., Whitman, Grant R., Arnold, Samuel L.M., Ojo, Kayode K., Van Voorhis, Wesley C., Doggett, J. Stone, Ortega-Mora, Luis M., and Hemphill, Andrew
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- 2021
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7. Antimalarial proteasome inhibitor reveals collateral sensitivity from intersubunit interactions and fitness cost of resistance
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Kirkman, Laura A., Zhan, Wenhu, Visone, Joseph, Dziedziech, Alexis, Singh, Pradeep K., Fan, Hao, Tong, Xinran, Bruzual, Igor, Hara, Ryoma, Kawasaki, Masanori, Imaeda, Toshihiro, Okamoto, Rei, Sato, Kenjiro, Michino, Mayako, Alvaro, Elena Fernandez, Guiang, Liselle F., Sanz, Laura, Mota, Daniel J., Govindasamy, Kavitha, Wang, Rong, Ling, Yan, Tumwebaze, Patrick K., Sukenick, George, Shi, Lei, Vendome, Jeremie, Bhanot, Purnima, Rosenthal, Philip J., Aso, Kazuyoshi, Foley, Michael A., Cooper, Roland A., Kafsack, Bjorn, Doggett, J. Stone, Nathan, Carl F., and Lin, Gang
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- 2018
8. Genome Sequence of the Enterobacterial Phytopathogen Erwinia carotovora Subsp. atroseptica and Characterization of Virulence Factors
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Bell, K. S., Sebaihia, M., Pritchard, L., Holden, M. T. G., Hyman, L. J., Holeva, M. C., Thomson, N. R., Bentley, S. D., Churcher, L. J. C., Mungall, K., Atkin, R., Bason, N., Brooks, K., Chillingworth, T., Clark, K., Doggett, J., Fraser, A., Hance, Z., Hauser, H., Jagels, K., Moule, S., Norbertczak, H., Ormond, D., Price, C., Quail, M. A., Sanders, M., Walker, D., Whitehead, S., Salmond, G. P. C., Birch, P. R. J., Parkhill, J., Toth, I. K., and Haselkorn, Robert
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- 2004
9. Endochin-like quinolone-300 and ELQ-316 inhibit Babesia bovis, B. bigemina, B. caballi and Theileria equi
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Silva, Marta G., Bastos, Reginaldo G., Stone Doggett, J., Riscoe, Michael K., Pou, Sovitj, Winter, Rolf, Dodean, Rozalia A., Nilsen, Aaron, and Suarez, Carlos E.
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- 2020
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10. Quinolone-3-amidoalkanol: A New Class of Potent and Broad-Spectrum Antimicrobial Agent
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Dube, Phelelisiwe S., primary, Angula, Klaudia T., additional, Legoabe, Lesetja J., additional, Jordaan, Audrey, additional, Boitz Zarella, Jan M., additional, Warner, Digby F., additional, Doggett, J. Stone, additional, and Beteck, Richard M., additional
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- 2023
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11. Endochin-like quinolones are highly efficacious against acute and latent experimental toxoplasmosis
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Doggett, J. Stone, Nilsen, Aaron, Forquer, Isaac, Wegmann, Keith W., Jones-Brando, Lorraine, Yolken, Robert H., Bordón, Claudia, Charman, Susan A., Katneni, Kasiram, Schultz, Tracey, Burrows, Jeremy N., Hinrichs, David J., Meunier, Brigitte, Carruthers, Vern B., and Riscoe, Michael K.
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- 2012
12. A New Scalable Synthesis of ELQ-300, ELQ-316, and other Antiparasitic Quinolones
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Pou, Sovitj, Dodean, Rozalia A., Frueh, Lisa, Liebman, Katherine M., Gallagher, Rory T., Jin, Haihong, Jacobs, Robert T., Nilsen, Aaron, Stuart, David R., Doggett, J. Stone, Riscoe, Michael K., and Winter, Rolf W.
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Article - Abstract
The Endochin-Like Quinolone (ELQ) compound class may yield effective, safe treatments for a range of important human and animal afflictions. However, to access the public health potential of this compound series, a synthetic route needed to be devised that lowers costs and is amenable to large scale production. In the new synthetic route described here, a substituted β-keto ester, formed by an Ullmann reaction and subsequent acylation, is reacted with an aniline via a Conrad-Limpach reaction to produce 3-substituted 4(1H)-quinolones such as ELQ-300 and ELQ-316. This synthetic route, the first described to be truly amenable to industrial scale production, is relatively short (5 reaction steps), does not require palladium, chromatographic separation or protecting group chemistry, and may be performed without high vacuum distillation.
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- 2021
13. Effective Therapy Targeting Cytochrome bc 1 Prevents Babesia Erythrocytic Development and Protects from Lethal Infection
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Chiu, Joy E., primary, Renard, Isaline, additional, Pal, Anasuya C., additional, Singh, Pallavi, additional, Vydyam, Pratap, additional, Thekkiniath, Jose, additional, Kumar, Madelyn, additional, Gihaz, Shalev, additional, Pou, Sovitj, additional, Winter, Rolf W., additional, Dodean, Rozalia, additional, Frueh, Lisa, additional, Nilsen, Aaron C., additional, Riscoe, Michael K., additional, Doggett, J. Stone, additional, and Mamoun, Choukri Ben, additional
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- 2021
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14. Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
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Ridker PM, Everett BM, Thuren T, MacFadyen JG, Chang WH, Ballantyne C, Fonseca F, Nicolau J, Koenig W, Anker SD, Kastelein JJP, Cornel JH, Pais P, Pella D, Genest J, Cifkova R, Lorenzatti A, Forster T, Kobalava Z, Vida-Simiti L, Flather M, Shimokawa H, Ogawa H, Dellborg M, Rossi PRF, Troquay RPT, Libby P, Glynn RJ, Novo S, Krum H, Varigos J, Siostrzonek P, Sinnaeve P, Gotcheva N, Yong H, Urina-Triana M, Milicic D, Vettus R, Manolis AJ, Wyss F, Sigurdsson A, Fucili A, Veze I, Petrauskiene B, Salvador L, Klemsdal TO, Medina F, Budaj A, Otasevic P, Lainscak M, Seung KB, Commerford P, Donath M, Hwang JJ, Kultursay H, Bilazarian S, East C, Forgosh L, Harris B, Ligueros M, Bohula E, Charmarthi B, Cheng S, Chou S, Danik J, McMahon G, Maron B, Ning M, Olenchock B, Pande R, Perlstein T, Pradhan A, Rost N, Singhal A, Taqueti V, Wei N, Burris H, Cioffi A, Dalseg AM, Ghosh N, Gralow J, Mayer T, Rugo H, Fowler V, Limaye AP, Cosgrove S, Levine D, Lopes R, Scott J, Hilkert R, Tamesby G, Mickel C, Manning B, Woelcke J, Tan M, Manfreda S, Ponce T, Kam J, Saini R, Banker K, Salko T, Nandy P, Tawfik R, O’Neil G, Manne S, Jirvankar P, Lal S, Nema D, Jose J, Collins R, Bailey K, Blumenthal R, Colhoun H, Gersh B, Abreu M, Actis MV, Aiub J, Aiub F, Albisu J, Alvarisqueta A, Avalos V, Barreto M, Berli MA, Blumberg C, Bocanera M, Botta C, Bowen L, Budassi N, Buhlman S, Westberg JC, Carabajal T, Caruso G, Casala J, Cendali G, Coloma G, Berra FC, Cuneo C, Degennaro N, Dellasa M, Diaz M, Dos Santos P, Espinosa V, Facello A, Facello M, Farias E, Fernandez AA, Ferrari V, Pacora FF, Flores GS, Franco M, Gabito A, Viola HG, Garcia F, Garcia Duran R, Garcia Pinna J, Glenny J, Godoy Sanchez M, Grosse A, Guzman P, Hasbani E, Hominal M, Ibañez J, Jure H, Jure D, Vico ML, Liniado G, Luciardi H, Luquez H, Maehara G, Maffei L, Majul C, Mallagray M, Marinaro S, Martinez J, Massaccesi R, De Los Milagros Had M, Azize GM, Montana O, Montenegro E, Morell Y, Muntaner J, Navarrete S, Olmedo M, Paganini M, Paz S, Perez Manghi F, Piskorz D, Polato C, Recoaro R, Romano A, Salinger M, Sanchez A, Saravia MA, Sarjanovich R, Scaro G, Schiavi LB, Soler J, Tinnirello V, Tomassi A, Valle M, Vallejo MA, Venturini C, Marcela Wenetz LM, Yossen M, Zaidman C, Zalazar L, Zangroniz P, Amerena J, Brady L, Colquhoun D, Eccleston D, Ferreira-Jardim A, French J, Jayasinghe R, Mcintosh C, Ord M, Plotz M, Purnell P, Roberts-Thomson P, Schultz C, Shanahan T, Tan R, Taverner P, Turner F, Vibert J, Vorster M, William M, Youssef G, Bergler-Klein J, Brath H, Brodmann M, Fliesser-Goerzer E, Haider K, Heeren G, Hiden C, Mandic L, Paulweber B, Ploechl A, Prenner A, Steringer-Mascherbauer R, Strohner-Kaestenbauer H, Barbato E, Bouvy C, Briké C, Charlier F, Cools F, De Knijf K, De Wolf L, Delforge M, Deweerdt N, Gits F, Goffinet C, Hermans K, Hollanders G, Mestdagh I, Pirenne B, Servaes V, Simons N, Tahon S, Theunissen E, Van Genechten G, Vervoort G, Vissers C, Vranckx P, Vrolix M, Abib E Jr, Abrantes J, Araujo Fonseca M, Barbosa E, Barroso W, Barroso A, Bodanese L, Botelho R, Costa Amorim R, Da Costa F, Da Silva A, Da Silva O Jr, Da Silva D Jr, Ferreira Dos Santos T, Dos Santos F, Dos Santos A, Duda N, Feitosa G, Felario Junior GA, Ferraz R, Filho P, Fonseca A, Wanderley FF, Freitas E, Fucci F, Marengo Garcia De Carvalho L, Hernandez M, Hettwer Magedanz E, Julião K, Kormann A, Lameira A, Lima F, Lino E, Maia L, Manenti E, Marchi AL, Fischer SM, Michalaros Y, Moraes J Jr, Moreira L, Pagnan M, Pesce F, Pinheiro L, Rassi S, Reis G, Reis H, Resende I, Roel A, Ruschel K, Saporito W, Saraiva JF, Seroqui M, Silva R, Unterkircher B, Vicente C, Vieira N, Xavier JP, Zucchetti C, Angelova I, Dimitrov G, Genova D, Gospodinov K, Goudev A, Grigorova V, Hristova K, Makedonska JJ, Katova T, Kostov K, Lazov P, Manov E, Manukov I, Manukov D, Milanova M, Kabakchieva VM, Petrov D, Petrusheva T, Pramatarova I, Raev D, Runev N, Sirakova-Taseva A, Tisheva-Gospodinova S, Todorova A, Tzekova M, Yakovova S, Yanev T, Abulencia K, Arora S, Baker A, Bata IR, Beaudry M, Belle Isle J, Bilodeau N, Boivin MC, Bolduc H, Bourgeois S, Brons S, Cantor W, Chaussé I, Chhabra A, Chouinard G, Cleveland T, Dattani D, Deslongchamps F, Diodati J, Drouin K, Duchesne L, Fontaine S, d'Amours DG, Gervais B, Gosselin G, Graham J, Grover A, Gupta A, Haldane H, Hartleib M, Hickey L, Huynh T, Johnston J, Julien VE, Lachance P, Lake J, Lamontagne C, Lauzon C, Lepage S, Maheux K, Manyari D, Martin E, McPherson C, Mehta S, Michaud N, Kouz SM, Murphy G, OKeefe D, Otis R, Ouimet F, Pandey S, Peck C, Perkins L, Richert L, Robbins K, Robinson S, Cabau JR, Ross B, Roy C, Roy M, Roy A, Rupka D, Affaki GS, Saunders K, Savard D, Soucy D, St Amour E, Thiessen S, Vertes G, Vezina M, Vincelli G, Weisnagel SJ, Zadra R, Chen J, Chen Y, Dong X, Feng Y, Feng Z, Fu G, Han B, Hao Y, He Y, He Z, Hong T, Jia Z, Jiang T, Jiang J, Jiang X, Ke Y, Li Y, Li Z, Li W, Li X, Liu P, Liu Y, Liu B, Liu S, Liu L, Lu Z, Lv Y, Ma C, Ma G, Peng L, Qing L, Ren L, Sang X, Song M, Sun Z, Wang J, Wang Y, Wei J, Wu W, Wu J, Xu H, Yan J, Yang P, Yang K, Yao Z, Yaoqing H, Yuan Z, Zhai Z, Zhang J, Zhang Y, Zhao R, Zhou H, Accini Mendoza JL, Aparicio CV, Castillo T, Chaverra I, Conrado Y, Coronel J, Cotes C, Cuentas I, Cuervo A, Dussan MA, Echeverria L, Hernandez E, Ibarra J, Isaza D, Jimenez D, Lopez P, Manzur F, Mejia I, Mendoza Y, Molina DI, Patino JM, Rodriguez D, Rodriguez LM, Rodriguez SM, Sanchez Vallejo G, Luz Serrano H, Sotomayor A, Urina M, Vesga B, Yupanqui H, Akrap B, Busic N, Ciglenecki N, Cmrecnjak J, Fucak E, Gabor M, Jeric M, Jutrisa N, Kordic K, Planinc I, Popovic Z, Radeljic V, Sesto I, Sutalo K, Tusek S, Belohlavek J, Budkova J, Busak L, Capova L, Cech V, Cermak O, Coufalova Z, Cyprian R, Dedek V, Dedkova S, Ferkl R, Hanak P, Hanustiakova A, Homza M, Horackova K, Houra M, Iveta H, Kaiserova L, Kala P, Karel I, Kellnerova I, Koleckar P, Kreckova M, Krupicka J, Lorenc Z, Machova V, Malik J, Masarikova L, Matyasek I, Mikus M, Mikusova T, Ondrasik J, Otava M, Palubova L, Pavlickova L, Peterka M, Petrova I, Pokorna B, Povolny P, Radvan M, Reznakova S, Rickova Z, Roszkowska P, Rotreklova M, Samkova D, Skalicka H, Slechticka A, Sternthal P, Telekes P, Tesak M, Vesely P, Vesely J, Vins P, Vitovec M, Vodnansky P, Zidova M, Keba E, Laane E, Pool T, Randvee L, Ratnik E, Reimand M, Reinmets S, Rivis L, Siemann M, Stern M, Toom M, Vahula V, Apel T, Axthelm C, Ayasse D, Ayasse M, Baar M, Baeumer A, Bagi ES, Becker B, Binder A, Blankenberg S, Braun P, Johansen BB, Contzen C, Delfonso F, Denecke C, Dengler T, Donaubauer T, Eichinger G, Englmann E, Erhard M, Faghih M, Foerster A, Frankenstein L, Fuchs R, Furch G, Gaeb-Strasas B, Germann H, Giese C, Goette A, Gravenhorst-Muenter U, Haege R, Haenel T, Hagemann D, Hagenow A, Hanefeld M, Heider J, Heisters J, Hennig D, Hielscher S, Himpel-Boenninghoff A, Holscher A, Hornig M, Jeserich M, Kaczmarek N, Kanitz S, Kara YD, Khariouzov A, Kiefer R, Kiroglu K, Klamm M, Klein C, Korth-Wiemann B, Krapivsky A, Kuenzler J, Kuntzsch A, Landers B, Lappo M, Laube S, Leggewie S, Lehmann D, Lepp H, Lierse T, Lindner C, Luecke-Uzar M, Luedemann J, Marschke T, Maruzzo S, Mauersberger K, Maus O, Meinrich M, Meissner A, Moehring B, Muehlhaus J, Mueller S, Muenter KC, Muenzel T, Naumann R, Nebel J, Neumann J, Nuding S, Overhoff U, Papke B, Pencz I, Peter Y, Peukert AM, Radde I, Rau T, Regner S, Reichenbach D, Reimer D, Rinke A, Roettges R, Romanski A, Rummel R, Samer H, Sanuri M, Sarnighausen HE, Schäfer B, Scheibner T, Schermaul KH, Schindler A, Schlundt C, Schmidt E, Schmidt K, Schnabel A, Schoen N, Schorn K, Schroeder T, Schulenburg D, Schulz M, Schulze U, Schulze J, Schumacher M, Schwerin G, Schwerin M, Stadelmeier S, Stahl HD, Stahl A, Stockhausen J, Stockhausen G, Stoessel J, Stolze K, Stratmann M, Szymanowski N, Teschner AB, Teske A, Uecker C, Veit S, Voeller H, Walter I, Walter J, Walther I, Weber HG, Weimer J, Wichterich K, Wiebusch A, Willmerdinger M, Willner C, Winkelmann B, Winkler J, Wistuba T, Woehrle J, Wohnlich T, Wolf S, Woyczak D, Wrage P, Zirlik A, Anadiotis A, Chachalis G, Dermitzakis A, Kafarakis P, Kaldara E, Kolokathis F, Kostakou P, Lekakis J, Manolis A, Mantas I, Megalou A, Milkas A, Nanas J, Olympios CD, Patsilinakos S, Perperis A, Poulimenos L, Saloustros I, Tsioufis K, Tsorbatzoglou K, Vardas P, Zarifis I, Aguilar M, Arango JL, Borrayo NA, Corona V, Guerrero A, Guzman I, Haase F, De Krumbach L, Montenegro P, Munoz R, Munoz N, Paniagua A, Solares A, Vogel M, Anita S, Blazsek Z, Decsi K, Fulop T, Hangyal T, Hegedus V, Kalina A, Karakai H, Katona A, Kiss RG, Kovacs A, Laszlo Z, Lupkovics G, Medvegy M, Merkely B, Mihaly N, Nagy AC, Dékány JN, Nikoletta P, Noori E, Penzes J, Poor F, Sarszegi Z, Simay A, Simon J, Szakal I, Szatmarine V, Szocs A, Zilahi Z, Karsai XZ, Andersen K, Sigurdadottir E, Skuladottir F, Abdullakutty J, Abhaichand R, Abhyankar A, Agarwal DK, Aggarwal RK, Ahire N, Awasthi AK, Babu R, Bai A, Bali HK, Banker D, Bhadade S, Bisne V, Bohra P, Raghu C, Chauhan D, Chauhan H, Chavada J, Chaware G, Chella S, Chintala P, Dash D, Desai D, Devasia T, Dhanak R, Dobariya H, Dudhatra N, Duhan S, Fulwani M, Ghondale N, Ghosh S, Gohel P, Govindaraj D, Goyal B, Goyal S, Gundala AK, Gupta M, Hardas S, Iby M, Jagtap P, Jain A, Joshi U, Karpuram M, Kaur H, Khan A, Khan R, Kodem DR, Koeitti P, Kulkarni L, Kullal P, Kumar KS, Kumbla M, Latheef K, Lohkare M, Santosh MJ, Makhe B, Mandati M, Mehta A, Minocha G, Mittal A, Modi R, Mohan K, Oomman A, Pai R, Pai V, Palaniswami N, Pansheriya A, Parekh N, Patel J, Patel R, Patole T, Praveen M, Radhakrishnan V, Rajan B A, Rajasekhar D, Rao M, Rao MB, Rao NM, Rathnavel S, Rathore A, Rathore SRS, Rawat S, Reddy NC, Sarma R, Sathe S, Shah J, Shaikh P, Sharma K, Sharma S, Sharma T, Shetty P, Sidhu G, Singh V, Sohi GS, Srinath VS, Raju SS, Taran A, Thakkar B, Velusamy K, Vijan V, Vora V, Vuriya AK, Agosta GF, Antonicelli R, Ardissino D, Argiolas G, Baldin MG, Benedetti G, Berti S, Bevilacqua MT, Bolognesi MG, Dessalvi CC, Calabrese A, Campanale EG, Candusso R, Caso P, Cosmi F, Crea F, Crocamo A, De Caterina R, De Rosa S, Destro M, Di Biase M, Dognini GP, Eleuteri E, Fedele F, Ferrario M, Gabrielli D, Gamba C, Ganau A, Gravellone M, Iannopollo G, Indolfi C, Infusino F, Invitti C, Landolfi A, Lembo G, Liberato NL, Mannucci E, Marino P, Mariottoni B, Marziali A, Mercuro G, Monti L, Mos L, Mureddu V, Musumeci MB, Panzarino C, Parente A, Perotti M, Filardi PP, Petrillo C, Piatti P, Priori S, Racca V, Ragghianti B, Renda G, Righini V, Sarcone M, Senni M, Soro E, Tamburrini P, Vallone L, Villani GQ, Volpe M, Ajioka M, Akai Y, Ashino K, Baden M, Doi M, Eki Y, Endo T, Fukuike C, Hagiwara Y, Hasegawa K, Higuchi Y, Higuchi T, Hioki M, Hirayama A, Hiroma J, Hosokawa S, Ichisawa M, Iijima T, Inada T, Inagaki M, Ito K, Kaigawa K, Kajihara S, Kamiya H, Kamiya J, Kaneno Y, Katahira K, Kataoka M, Kawai M, Kawasaki T, Kojima E, Komura Y, Kuramochi T, Kuruma T, Kyo E, Mani H, Miyamoto T, Morii I, Morinaga Y, Morisawa T, Nagai Y, Naka T, Nakamura Y, Nakamura S, Nakayoshi K, Nishibe A, Ogawa M, Okada Y, Okawa M, Sakamoto Y, Sakurada M, Sasaki S, Seki S, Shimomura H, Shinozaki T, Sugimoto N, Suzuki A, Taguchi S, Takahashi J, Takase S, Tanabe K, Tanaka A, Tani S, Tomioka J, Tsuboi H, Tsuji M, Tsujita K, Tsujiyama S, Umesu A, Yamada T, Yamaguchi E, Yamamoto H, Yamamoto T, Yamane M, Yanase T, Yasuoka S, Yasutake M, Yokoyama M, Yoshida M, Yoshimoto E, Yunoki C, Balode A, Dormidontova G, Flaksa I, Nagele-Luse I, Rancane G, Sime I, Bartuseviciene S, Cepinskiene L, Dobilas V, Grigaraviciene I, Marcinkeviciene J, Mazutavicius R, Miliuniene R, Motiejuniene R, Norkiene S, Norkute-Macijauske U, Rudys A, Slapikas R, Stonkute K, Strazdiene D, Tijuneliene E, Urbonas G, Vanagiene S, Viezelis M, Arenas Leon JL, Bayram E, Carrillo J, Davalos C, De Los Rios M, Delgadillo T, Hernández N, Leon S, Mendoza N, Muñoz W, Ramos G, Anneveldt A, Bakker H, Brouwer M, Bunschoten P, De Boer 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Kolokathis F, Kostakou P, Lekakis J, Manolis A, Mantas I, Megalou A, Milkas A, Nanas J, Olympios CD, Patsilinakos S, Perperis A, Poulimenos L, Saloustros I, Tsioufis K, Tsorbatzoglou K, Vardas P, Zarifis I, Aguilar M, Arango JL, Borrayo NA, Corona V, Guerrero A, Guzman I, Haase F, De Krumbach L, Montenegro P, Munoz R, Munoz N, Paniagua A, Solares A, Vogel M, Anita S, Blazsek Z, Decsi K, Fulop T, Hangyal T, Hegedus V, Kalina A, Karakai H, Katona A, Kiss RG, Kovacs A, Laszlo Z, Lupkovics G, Medvegy M, Merkely B, Mihaly N, Nagy AC, Dékány JN, Nikoletta P, Noori E, Penzes J, Poor F, Sarszegi Z, Simay A, Simon J, Szakal I, Szatmarine V, Szocs A, Zilahi Z, Karsai XZ, Andersen K, Sigurdadottir E, Skuladottir F, Abdullakutty J, Abhaichand R, Abhyankar A, Agarwal DK, Aggarwal RK, Ahire N, Awasthi AK, Babu R, Bai A, Bali HK, Banker D, Bhadade S, Bisne V, Bohra P, Raghu C, Chauhan D, Chauhan H, Chavada J, Chaware G, Chella S, Chintala P, Dash D, Desai D, Devasia T, Dhanak R, Dobariya H, Dudhatra 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Y, Sakurada M, Sasaki S, Seki S, Shimomura H, Shinozaki T, Sugimoto N, Suzuki A, Taguchi S, Takahashi J, Takase S, Tanabe K, Tanaka A, Tani S, Tomioka J, Tsuboi H, Tsuji M, Tsujita K, Tsujiyama S, Umesu A, Yamada T, Yamaguchi E, Yamamoto H, Yamamoto T, Yamane M, Yanase T, Yasuoka S, Yasutake M, Yokoyama M, Yoshida M, Yoshimoto E, Yunoki C, Balode A, Dormidontova G, Flaksa I, Nagele-Luse I, Rancane G, Sime I, Bartuseviciene S, Cepinskiene L, Dobilas V, Grigaraviciene I, Marcinkeviciene J, Mazutavicius R, Miliuniene R, Motiejuniene R, Norkiene S, Norkute-Macijauske U, Rudys A, Slapikas R, Stonkute K, Strazdiene D, Tijuneliene E, Urbonas G, Vanagiene S, Viezelis M, Aguilar M, Arenas Leon JL, Bayram E, Carrillo J, Davalos C, De Los Rios M, Delgadillo T, Hernández N, Leon S, Mendoza N, Muñoz W, Ramos G, Anneveldt A, Bakker H, Brouwer M, Bunschoten P, De Boer P, De Jong C, De Vos A, Den Hartog F, Doesborg L, Dommerholt R, Drost I, Ellenbroek D, Engelen W, Folkeringa RJ, Hamer BJB, Herrman JP, Hoogslag PAM, Jansen M, Jerzewski A, Joosten C, Kalkman C, Kietselaer B, Kok M, Kooiman E, Kose V, Lardinois R, Lenderink T, Lok DJA, Lousberg A, Meijlis P, Mulder R, Singerling M, Smeele F, Stroes E, Swart HP, Ten Holt W, Van Der Wal M, Van Der Zwaan C, Van Kempen WW, Van Maarseveen M, Van Stein I, Viergever EP, Visseren FLJ, Voors C, Nugteren SKZ, Ata B, Berulfsen A, Rønnevik TD, Dickstein K, Furuseth B, Grundtvig M, Hansen H, Hofsoey K, Høivik HO, Bøen RH, Hurtig U, Pettersen KI, Johansen E, Kleve R, Kolleroy C, Moen S, Nilsen V, Norin V, Otterstad JE, Risberg K, Rønnevik P, Sirnes PA, Skjelvan G, Strand S, Szacinski G, Vegsundvåg J, Alcalde JM, Gomez Sanchez J, Rodriguez J, Rodriguez A, Zena N, Baszak J, Cymerman K, Czerski T, Fratczak M, Jaguszewska G, Kawka-Urbanek T, Koba M, Kopaczewski J, Kopczyńska M, Laniec M, Lysek R, Sciborski R, Szpajer M, Torun A, Wujkowski M, Zielinski M, Ahn Y, Baek C, Bang SA, Chang K, Choi AJ, Han S, Hong T, Hyun K, Kim M, Kim KS, Kim B, Lee SH, 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Skopets I, Skuratova M, Smolenskaya O, Solovev O, Trofimov V, Vasiliev M, Vezikova N, Vozzhaev A, Yakushin S, Zadionchenko V, Apostolovic S, Adjic NC, Ilic I, Ilic S, Nikolic L, Pupic L, Stokuca-Korac N, Antalik L, Bugan V, Csala L, Dokupilova A, Dzupina A, Forgon T, Fulop P, Gonsorcik J, Gyorgyova E, Holoubek D, Horvat P, Kamensky G, Kolikova V, Krupciakova B, Lenner E, Lennerova J, Lukac J, Majercak I, Mancikova I, Micko K, Nociar J, Pales J, Palka J Jr, Poliacik P, Ruffini L, Sabo L, Skubova K, Slanina M, Smik R, Srdos V, Stitova M, Stofkova D, Strbova J, Such S, Toth P, Urgeova L, Vinanska D, Zareczky P, Flezar M, Kovacic D, Marcun R, Zagozen P, Bolsmann C, Commerford P, Conradie C, Dawood SY, Decsi KL, Ebrahim I, Henley L, Horak A, Kapp I, Komati S, Lock E, Maboyi S, Makotoko E, Manga P, Page A, Ramdas S, Ranjith N, Roos J, Talliard C, Ajax K, Al-Khalili F, Assarsson E, Bergholtz T, Blom KB, Boman K, Boström PÅ, Curiac D, Jensen ED, Dahlen G, Davidsson K, Duckert A, Hansson A, Härstedt N, Henriksson A, Olsson GH, Johansson K, Jonsson JE, Knutsson A, Lindholm CJ, Liu B, Lönnberg I, Lundqvist M, Mellberg L, Moodh J, Mooe T, Olofsson M, Risenfors M, Rönndahl M, Sundelin R, Suorra I, Torgersruud M, Torstensson I, Chang KC, Chen CP, Chen ZC, Chen MH, Cheng SM, Cheng JJ, Fang CY, Ho CJ, Hsieh IC, Huang PH, Huang A, Hwang JJ, Kuo JY, Lai WT, Lee SC, Li YH, Lin T, Liu HM, Tsai MC, Tsao HM, Tzong L, Ueng KC, Wang YL, Wang HC, Wang CP, Yang CC, Abaci F, Birdane A, Yilmaz MB, Asim Oktay AO, Kan G, Koldas N, Ozcan IT, Sahin M, Sahin T, Saka B, Tekten T, Ucar N, Uresin S, Yigit Z, Arif I, Bakhai A, Baksi A, Blagdon M, Brickman T, Brown N, Burton M, Burton J, Chaggar S, Chung A, Collier D, Covell W, Crawford G, Davies N, Davies M, Dayer M, Doughty A, Duff J, Dwenger E, Fisher J, Fitzpatrick L, Garner K, Glover J, Haughton G, Ilsley M, Ivan P, Voyzey EJ, Keenan S, Kelt T, Knight J, Kondagunta V, Lang C, Lee K, Lim L, Macdonald J, Mathew A, Mckenzie A, Mckibbin A, Michalska A, Pagett K, Pogson A, Price R, Price D, Procter K, Pye M, Redfearn H, Rewbury J, Ryding A, Sattar N, Sharp A, Shaw P, Simpson H, Smith W, Squire I, Storey R, Teenan M, Thomas H, Townend J, Trevelyan J, Wakeling J, Walukiewicz P, Wilkinson S, Zaman A, Acevedo L, Benton J, Abbate A, Aboufakher R, Acampora M, Acampora D, Aceto L, Acevedo B, Acheatel R, Adams M, Adams A, Ahmad I, Ahmed SH, Aish B, Akyea-Djamson A, Al Joundi T, Alcide P, Alfieri A, Alfonso T, Alfrey A, Allen J, Alllison DC, Almaliky T, Amos A, Angiolillo D, Antolick A, Ara M, Aragorn L, Arevalo S, Armas E, Arthur A, Asafu-Adjaye N, Ashcom T, Ashford M, Aslam A, Ather N, Atieh M, Aull L, Ayala M, Azizad M, Backer T, Baehl S, Bailey S, Bair S, Baker C, Ballmajo M, Pieretti HB, Baquero A, Barnett S, Baron S, Bartkowiak A, Bashir K, Beall K, Beauregard LA, Sarah S, Beckett L, Belejchak P, Bendelow T, Bender D, Benjamin S, Berdoff R, Berger V, Bergeron P, Berk M, Bernstein M, Binns Y, Bitzer V, Blahey M, Bloch S, Bluemel J, Boffetti P, Boley K, Bonner J, Boudreaux R, Boulanger K, Bradley A, Bramlet D, Bredlau C, Briggs S, Brousalis L, Brown S, Brown C, Buchannan C, Burke W, Burley T, Burton C, Burtt D, Byars W, Caballero-Valiente B, Carr K, Halliwell TC, Castillo J, Cei L, Cerda L, Chambers J, Chamblee T, Chattin W, Chee L, Chen YC, Cherlin R, Cheung D, Chiodi L, Christensen L, Christenson S, Cislowski D, Clavier-Firmin C, Colfer H, Colvin T, Cosgrove N, Covert C, Cox B, Cox R, Craig W, Crandall L, Crepps K, Cromer M, Cruz H, Cruz H, Cruz M, Cucher F, Damron M, Dave K, Dave B, Davis M, Davis B, Dawkins-Hughes S, Dean J, Debnam S, Defosse C, Dehning M, Dela Llana A, Dellorso M, Denham D, Desalle D, Dettmer M, Dhawan M, Diago M, Dicken T, Diederich C, Diederich M, Diehl R, Digangi D, Diller P, Dimattia M, Dodds G, Doggett J, Donahue K, Doughty L, Dragutksy B, Dreese M, Dunhurst F, Dunn D, Dutka C, Earl J, Eaton C, Eaves W, Ebeling K, Eder F, Edgerton L, Edillo C, Edwards J, Edwards T, Einhorn D, El Hafi S, Ellis M, Erickson B, Ervin W, Eskridge L, Fail P, Falcon D, Fang C, Fattal P, Fawson A, Felix L, Ferdinand K, Fien E, Fintel D, Firek C, Fitz-Patrick D, Flores E, Flores E, Flores H, Floro T, Forker A, Foster M, Foucauld J, Lehman KF, Fox B, Francoeur L, Frandsen B, Frandsen B, Frivold G, Fruchter G, Fullerton D, Gabriel J, Gacioch G, Garas S, Garcia N, Garcia Rinaldi R, Garcia-Fragoso V, Garcia-Portela M, Gelb R, George F, Ghali J, Gilbert J, Gilley J, Glancy R, Goff R, Goldberg N, Gonzales D, Gonzales V, Gonzalez E, Gorges R, Gould R, Grabeau R, Grable M, Graham JA, Graif J, Green E, Greener R, Greenway F, Grieshaber V, Griffin S, Gros C, Gudipati RVC, Guillinta P, Gupta V, Gutmann J, Gwyn M, El Hachem M, Hage F, Hageman T, Haidar A, Hakas J, Haldis T, Hall L, Hall C, Hall S, Halpern S, Hamud-Socoro A, Hardee L, Harrell W, Harrington A, Hartwell J, Hasan F, Hattler B, Haught H, Haynes E, Haywood A, Heaney L, Hecht J, Hernandez I, Herzog W, Hess E, Hill H, Hilton T, Hinderaker P, Hodnett P, Hoffman M, Hogan C, Holmes Z, Rees DH, Hotchkiss D, Huang P, Humbert J, Hutchens E, Iachini K, Ibarra M, Igbokidi O, Ilahi T, Imbrognio M, Ipp E, Iteld B, Jacques G, Jafri A, Jafry B, Jardula M, Jefferson D, Jenkins R, Johnson E, Johnson J, Jones S, Kawahara M, Kelehan S, Kelly R, Kendall T, Kereiakes D, Khan M, Khan S, Kick J, Kimmel M, King T, King A, Kirkland S, Kissel S, Kitchens D, Klein P, Klugherz B, Korban E, Koren M, Korte M, Kostis J, Kotek L, Kozak M, Kreutter F, Kusnick B, Labovitz R, Lail J, Lamance J, Lamas G, Lambert J, Lambert C, Landzberg J, Langdon J, Lavoie W, Ledger G, Lee T, Lee K, Lehman R, Leimbach W, Lennard M, Lepor N, Lester F, Levin P, Levinson L, Lewis D, Lillo J, Link L, Long C, Longaker R, Lorch G, Lucksinger G, Lynd S, Rhudy JM, Madder R, Magness K, Maheshwari A, Alan A, Malek M, Maletz L, Malhotra V, Malhotra S, Mandviwala M, Mani CK, Manuel J, Marchelletta N, Marshall L, Marsters M, Martin L, Martinez E, Mavromatis K, Maynard R, Mays M, Mays B, Mbulaiteye A, Mcalister R, Mccoy C, Mccrary D Jr, Mccullough-O'Brien H, Mcdonald M, Mcgill J, Mcgrew F, Mckenzie C, Mclaurin B, Mclellan BA, Mcneil D, Mcneill R, Mehrle A, Melbie K, Melliza T, Messina T, Meyer R, Michel K, Mikdadi G, Miller C, Miller R, Miller A, Miller G, Miller W, Mitchell J, Moats DJR, Mody F, Moffat J, Molk B, Molter D, Monroe T, Montero H, Montgomery R, Mookherjee D, Moran J, Moriarty P, Morrison J, Morton D, Moshayedi P, Mosley J, Moustafa M, Munshi K, Murray A, Mustafa J, Nadar V, Naidu R, Nalley J, Navy S, Neil L, Neutel JM, Niblack P, Nicely V, Nicolai M, Nijmeh G, Nikas A, Nikyar A, Nixon S, Norman L, Noto G, Nour K, Nugent A, Ocman B, Odegard A, Olsen S, Ortiz-Carrasquillo R, Ossino N, Paez H, Palchick B, Paliwal Y, Pannell R, Parfait V, Partridge J, Patel B, Patel R, Patel M, Patel S, Paysor C, Pena A, Pereira S, Perez M, Perez A, Perkins H, Perry B, Peters P, Phillippi C, Phillips A, Phillips A, Piacente R, Pintado M, Pish R, Pitt W, Poling T, Pomposini D, Poock J, Potts J, Poudrier R, Prior J, Pritchard C, Purighalla R, Quddusi K, Quinones J, Quinton D, Radin M, Radojcsics B, Rajput B, Rama B, Ramos M, Rauch R, Raynes K, Reber AM, Reddy J, Reeves M, Reilly K, Renaud K, Resnick H, Reyes R, Richardson M, Riethof M, Riser J, Rodero M, Rodriguez Araya E, Roper L, Rozeman P, Ruder D, Runquist L, Sack G, Saint-Jacques H, Salfity M, Sall N, Sam K, Samal A, Sanchez D, Santiago J Jr, Savignano C, Saylor R, Scheffel M, Schifferdecker B, Schindler E, Schneider P, Schneider R, Schnitzler R, Schrager B, Schwartz A, Scott R, Seals A, Shah AV, Shah A, Shatsky K, Shayani S, Shealy N, Sheets L, Shelley J, Shepard P, Shetty S, Silver K, Simon M, Singh K, Singh N, Sizemore BC, Skatrud L, Slayton C, Slimak V, Sloane G, Smallwood B, Smith P, Smith M, Smith T, Smith G, Smith B, Smith W, Smith M, Smith J, Smith J, Soca Y, Sofley C, Sopko K, Sosa-Padilla M, Sotolongo R, Sprinkle B, Srivastava S, Starzec M, Steinhoff J, Stelly L, Stinson J, Stoddard M, Stoltz S, Stone B, Stover T, Strain J, Strugatsky S, Stys T, Suleman A, Sullivan P, Tamez W, Tandon N, Teltser M, Terry PS, Terry K, Tessmar C, Thekkoott D, Thomas D, Thomas DM, Thompson E, Thompson J, Thornton A, Tjaden T, Tobias C, Topper J, Tran A, Treasure C, Trenkamp P, Trevino M, Tsou L, Tuholske C, Uy W, Vahtel M, Vaid B, Valenzuela M, Vance A, Vandam J, Vanhecke T, Vanness WC III, Vargas R, Vaz S, Vazquez Tanus J, Veerina K, Vega J, Vento A, Vijay N, Voelker F, Vogt E, Vold D, Vora K, Wade RD, Wadell C, Waksman R, Walker K, Walker K, Wallace K, Warren M, Washam M, Watson B, Webel R, Wells T, West M, Whitaker J, White J, White C, White A, White A, Wilhoit G, Wilkins M, Willingham K, Wilson S, Wilson V, Wise J, Woodall S, Woods A, Wright J, Wu J, Xu ZJ, Yarows S, Young A, Younis L, Zarate J, Zebrack J, Zhang W, Zieve F, Zineldine A, Ridker, P. M., Everett, B. M., Thuren, T., Macfadyen, J. G., Chang, W. H., Ballantyne, C., FONSECA E PIRES, CARLOS EDUARDO, Nicolau, J., Koenig, W., Anker, S. D., Kastelein, J. J. P., Cornel, J. H., Pais, P., Pella, D., Genest, J., Cifkova, R., Lorenzatti, A., Forster, T., Kobalava, Z., Vida-Simiti, L., Flather, M., Shimokawa, H., Ogawa, H., Dellborg, M., Rossi, P. R. F., Troquay, R. P. T., Libby, P., Glynn R., J, CANTOS Trial, Group, Perrone, Filardi, P, ACS - Amsterdam Cardiovascular Sciences, Vascular Medicine, ACS - Pulmonary hypertension & thrombosis, and ACS - Atherosclerosis & ischemic syndromes
- Subjects
0301 basic medicine ,030204 cardiovascular system & hematology ,law.invention ,0302 clinical medicine ,c-reactive protein ,Randomized controlled trial ,law ,Cardiovascular Disease ,middle aged ,double-blind method ,antibodies ,Myocardial infarction ,humans ,Stroke ,interleukin-1beta ,biology ,Antibodies, Monoclonal ,drug ,General Medicine ,Lipid ,Aged ,anti-inflammatory agents ,monoclonal ,humanized ,atherosclerosis ,cardiovascular diseases ,dose-response relationship ,female ,incidence ,infections ,lipids ,male ,myocardial infarction ,neutropenia ,secondary prevention ,stroke ,Anti-Inflammatory Agent ,aged ,Editorial ,Atherosclerosi ,Monoclonal ,Human ,medicine.drug ,medicine.medical_specialty ,Neutropenia ,Antibodies, Monoclonal, Humanized ,Infections ,Placebo ,antibodies, monoclonal ,dose-response relationship, drug ,infection ,medicine (all) ,03 medical and health sciences ,Internal medicine ,medicine ,Dose-Response Relationship, Drug ,business.industry ,Antiinflammatory Therapy, Canakinumab, for Atherosclerotic Disease ,C-reactive protein ,medicine.disease ,Surgery ,Canakinumab ,030104 developmental biology ,biology.protein ,business - Abstract
Background: Experimental and clinical data suggest that reducing inflammation without affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory hypothesis of atherothrombosis has remained unproved. Methods: We conducted a randomized, double-blind trial of canakinumab, a therapeutic monoclonal antibody targeting interleukin-1β, involving 10,061 patients with previous myocardial infarction and a high-sensitivity C-reactive protein level of 2 mg or more per liter. The trial compared three doses of canakinumab (50 mg, 150 mg, and 300 mg, administered subcutaneously every 3 months) with placebo. The primary efficacy end point was nonfatal myocardial infarction, nonfatal stroke, or cardiovascular death. RESULTS: At 48 months, the median reduction from baseline in the high-sensitivity C-reactive protein level was 26 percentage points greater in the group that received the 50-mg dose of canakinumab, 37 percentage points greater in the 150-mg group, and 41 percentage points greater in the 300-mg group than in the placebo group. Canakinumab did not reduce lipid levels from baseline. At a median follow-up of 3.7 years, the incidence rate for the primary end point was 4.50 events per 100 person-years in the placebo group, 4.11 events per 100 person-years in the 50-mg group, 3.86 events per 100 person-years in the 150-mg group, and 3.90 events per 100 person-years in the 300-mg group. The hazard ratios as compared with placebo were as follows: in the 50-mg group, 0.93 (95% confidence interval [CI], 0.80 to 1.07; P = 0.30); in the 150-mg group, 0.85 (95% CI, 0.74 to 0.98; P = 0.021); and in the 300-mg group, 0.86 (95% CI, 0.75 to 0.99; P = 0.031). The 150-mg dose, but not the other doses, met the prespecified multiplicity-adjusted threshold for statistical significance for the primary end point and the secondary end point that additionally included hospitalization for unstable angina that led to urgent revascularization (hazard ratio vs. placebo, 0.83; 95% CI, 0.73 to 0.95; P = 0.005). Canakinumab was associated with a higher incidence of fatal infection than was placebo. There was no significant difference in all-cause mortality (hazard ratio for all canakinumab doses vs. placebo, 0.94; 95% CI, 0.83 to 1.06; P = 0.31). Conclusions: Antiinflammatory therapy targeting the interleukin-1β innate immunity pathway with canakinumab at a dose of 150 mg every 3 months led to a significantly lower rate of recurrent cardiovascular events than placebo, independent of lipid-level lowering. (Funded by Novartis; CANTOS ClinicalTrials.gov number, NCT01327846.)
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- 2017
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15. Additional file 2 of Endochin-like quinolone-300 and ELQ-316 inhibit Babesia bovis, B. bigemina, B. caballi and Theileria equi
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Silva, Marta G., Bastos, Reginaldo G., Stone Doggett, J., Riscoe, Michael K., Pou, Sovitj, Winter, Rolf, Dodean, Rozalia A., Nilsen, Aaron, and Suarez, Carlos E.
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animal diseases ,parasitic diseases ,bacterial infections and mycoses - Abstract
Additional file 2: Table S1. IC50 calculated for different compounds tested against in vitro in B. bovis, B. bigemina, B. caballi and T. equi cultures. Table S2. Amino acid percentage identity of cytochrome bc1 complex (Cytb) of Babesia bovis, B. bigemina, B. caballi, and Theileria equi in comparison to B. microti.
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- 2020
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16. Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13
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Hall, N., Pain, A., Berriman, M., Churcher, C., Harris, B., Harris, D., Mungall, K., Bowman, S., Atkin, R., Baker, S., Barron, A., Brooks, K., Buckee, C. O., Burrows, C., Cherevach, I., Chillingworth, C., Chillingworth, T., Christodoulou, Z., Clark, L., Clark, R., Corton, C., Cronin, A., Davies, R., Davis, P., Dear, P., Dearden, F., Doggett, J., Feltwell, T., Goble, A., Goodhead, I., Gwilliam, R., Hamlin, N., Hance, Z., Harper, D., Hauser, H., Hornsby, T., Holroyd, S., Horrocks, P., Humphray, S., Jagels, K., James, K. D., Johnson, D., Kerhornou, A., Knights, A., Konfortov, B., Kyes, S., Larke, N., Lawson, D., Lennard, N., Line, A., Maddison, M., McLean, J., Mooney, P., Moule, S., Murphy, L., Oliver, K., Ormond, D., Price, C., Quail, M. A., Rabbinowitsch, E., Rajandream, M.-A., Rutter, S., Rutherford, K. M., Sanders, M., Simmonds, M., Seeger, K., Sharp, S., Smith, R., Squares, R., Squares, S., Stevens, K., Taylor, K., Tivey, A., Unwin, L., Whitehead, S., Woodward, J., Sulston, J. E., Craig, A., Newbold, C., and Barrell, B. G.
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Environmental issues ,Science and technology ,Zoology and wildlife conservation - Abstract
Author(s): N. Hall (corresponding author) [1]; A. Pain [1]; M. Berriman [1]; C. Churcher [1]; B. Harris [1]; D. Harris [1]; K. Mungall [1]; S. Bowman [1, 2]; R. Atkin [...]
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- 2002
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17. The Need for Antiviral Drugs for Pandemic Coronaviruses From a Global Health Perspective
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Villamagna, Angela Holly, primary, Gore, Sara J., additional, Lewis, James S., additional, and Doggett, J. Stone, additional
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- 2020
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18. Efficacy of Guanabenz Combination Therapy against Chronic Toxoplasmosis across Multiple Mouse Strains
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Martynowicz, Jennifer, primary, Doggett, J. Stone, additional, and Sullivan, William J., additional
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- 2020
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19. Orally Bioavailable Endochin-Like Quinolone Carbonate Ester Prodrug Reduces Toxoplasma gondii Brain Cysts
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Doggett, J. Stone, primary, Schultz, Tracey, additional, Miller, Alyssa J., additional, Bruzual, Igor, additional, Pou, Sovitj, additional, Winter, Rolf, additional, Dodean, Rozalia, additional, Zakharov, Lev N., additional, Nilsen, Aaron, additional, Riscoe, Michael K., additional, and Carruthers, Vern B., additional
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- 2020
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20. Activities of Endochin-Like Quinolones Against in vitro Cultured Besnoitia besnoiti Tachyzoites
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Eberhard, Naja, primary, Balmer, Vreni, additional, Müller, Joachim, additional, Müller, Norbert, additional, Winter, Rolf, additional, Pou, Soviti, additional, Nilsen, Aaron, additional, Riscoe, Mike, additional, Francisco, Samuel, additional, Leitao, Alexandre, additional, Doggett, J. Stone, additional, and Hemphill, Andrew, additional
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- 2020
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21. Targeted Structure-Activity Analysis of Endochin-like Quinolones Reveals Potent Qi and Qo Site Inhibitors of Toxoplasma gondii and Plasmodium falciparum Cytochrome bc(1) and Identifies ELQ-400 as a Remarkably Effective Compound against Acute Experimental Toxoplasmosis
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McConnell, Erin V., Bruzual, Igor, Pou, Sovitj, Winter, Rolf, Dodean, Rozalia A., Smilkstein, Martin J., Krollenbrock, Alina, Nilsen, Aaron, Zakharov, Lev N., Riscoe, Michael K., and Doggett, J. Stone
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Molecular Structure ,Phenyl Ethers ,Plasmodium falciparum ,Antiprotozoal Agents ,Drug Resistance ,Quinolones ,Article ,Electron Transport Complex III ,Mice ,Structure-Activity Relationship ,parasitic diseases ,Drug Discovery ,Animals ,Humans ,Malaria, Falciparum ,Toxoplasma ,Cells, Cultured ,Toxoplasmosis - Abstract
Cytochrome bc(1) inhibitors have been broadly studied as human and veterinary medicines, and agricultural fungicides. For the most part, cytochrome bc(1) inhibitors compete with ubiquinol at the ubiquinol oxidation (Qo) site or with ubiquinone at the quinone reduction (Qi) site. 4(1H)-Quinolones with 3-position substituents may inhibit either site based on quinolone ring substituents. 4(1H)-Quinolones that inhibit the Qi site are highly effective against toxoplasmosis, malaria and babesiosis and do not inhibit human cytochrome bc(1). We tested a series of 4(1H)-Quinolones against wild-type and drug resistant strains of Toxplasma gondii and Plasmodium falciparum. These experiments identified very potent compounds that inhibit T. gondii proliferation at picomolar concentrations. The most potent compounds target the Qo site, and for these compounds, an alkyl side chain confers potency against T. gondii greater than that of bulkier side chains. Our experiments also show that substituents on the quinolone ring influenced selectivity between T. gondii and P. falciparum and between Qo and Qi site-mediated activity. Comparison of the parasite cytochrome b sequences identified amino acids that are associated with drug resistance in P. falciparum that exist naturally in wild-type T. gondii. These underlying differences may influence drug susceptibility. Finally, a Qo site active 4(1H)-quinolone-3-diarylether tested in a murine model of toxoplasmosis was superior to atovaquone, resulting in survival from Type I strain T. gondii infection. These experiments identify highly effective compounds for toxoplasmosis and provide valuable insight into the structure-activity relationship of cytochrome bc(1) inhibitors.
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- 2018
22. Outlining a model of social journalism in health
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Sweet, M, Geia, L, Dudgeon, P, McCallum, K, Finlay, S, Williams, M, McInerney, M, Armstrong, R, Doggett, J, Coopes, A, Ward, M, Senior, T, and Ricketson, M
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GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries) - Abstract
Social journalism is an emerging field of practice that seeks to reframe journalism as an action-oriented service built on relationships and collaborations, rather than as primarily content or a product. It offers opportunities for innovation that re-centre the public interest roles of journalism at a time when public interest journalism is in crisis. This article outlines a 10-point model for social journalism, drawing on case studies in health journalism connected to the online platform Croakey.org. These case studies show how using decolonising and participatory action frameworks can transform journalism research and practice, with potential benefits for the health and wellbeing of Aboriginal and Torres Strait Islander people. They also illustrate a dynamic process of knowledge exchange between journalism research and practice. Elements of the proposed model for social journalism practice include: standpoint; transdisciplinary practice; connectivity; relationships; responsive listening; reflexivity; immersion; transparency and trust; creativity and innovation; and an ethic of service and outcomes. It is a model in which transformative health journalism facilitates and enables transformation in spheres beyond journalism. This article also considers the constraints and challenges facing social journalism initiatives and practitioners, and makes recommendations for policy.
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- 2017
23. Progress in Arabidopsis genome sequencing and functional genomics
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Wambutt, R, Murphy, G, Volckaert, G, Pohl, T, Düsterhöft, A, Stiekema, W, Entian, K.-D, Terryn, N, Harris, B, Ansorge, W, Brandt, P, Grivell, L, Rieger, M, Weichselgartner, M, de Simone, V, Obermaier, B, Mache, R, Müller, M, Kreis, M, Delseny, M, Puigdomenech, P, Watson, M, Schmidtheini, T, Reichert, B, Portatelle, D, Perez-Alonso, M, Boutry, M, Bancroft, I, Vos, P, Hoheisel, J, Zimmermann, W, Wedler, H, Ridley, P, Langham, S.-A, McCullagh, B, Bilham, L, Robben, J, Van der Schueren, J, Grymonprez, B, Chuang, Y.-J, Vandenbussche, F, Braeken, M, Weltjens, I, Voet, M, Bastiaens, I, Aert, R, Defoor, E, Weitzenegger, T, Bothe, G, Ramsperger, U, Hilbert, H, Braun, M, Holzer, E, Brandt, A, Peters, S, van Staveren, M, Dirkse, W, Mooijman, P, Klein Lankhorst, R, Rose, M, Hauf, J, Kötter, P, Berneiser, S, Hempel, S, Feldpausch, M, Lamberth, S, Van den Daele, H, De Keyser, A, Buysshaert, C, Gielen, J, Villarroel, R, De Clercq, R, Van Montagu, M, Rogers, J, Cronin, A, Quail, M, Bray-Allen, S, Clark, L, Doggett, J, Hall, S, Kay, M, Lennard, N, McLay, K, Mayes, R, Pettett, A, Rajandream, M.-A, Lyne, M, Benes, V, Rechmann, S, Borkova, D, Blöcker, H, Scharfe, M, Grimm, M, Löhnert, T.-H, Dose, S, de Haan, M, Maarse, A, Schäfer, M, Müller-Auer, S, Gabel, C, Fuchs, M, Fartmann, B, Granderath, K, Dauner, D, Herzl, A, Neumann, S, Argiriou, A, Vitale, D, Liguori, R, Piravandi, E, Massenet, O, Quigley, F, Clabauld, G, Mündlein, A, Felber, R, Schnabl, S, Hiller, R, Schmidt, W, Lecharny, A, Aubourg, S, Gy, I, Cooke, R, Berger, C, Monfort, A, Casacuberta, E, Gibbons, T, Weber, N, Vandenbol, M, Bargues, M, Terol, J, Torres, A, Perez-Perez, A, Purnelle, B, Bent, E, Johnson, S, Tacon, D, Jesse, T, Heijnen, L, Schwarz, S, Scholler, P, Heber, S, Bielke, C, Frishmann, D, Haase, D, Lemcke, K, Mewes, H.W, Stocker, S, Zaccaria, P, Mayer, K, Schüller, C, and Bevan, M
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- 2000
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24. Endochin-Like Quinolones Exhibit Promising Efficacy Against Neospora Caninum in vitro and in Experimentally Infected Pregnant Mice
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Anghel, Nicoleta, primary, Balmer, Vreni, additional, Müller, Joachim, additional, Winzer, Pablo, additional, Aguado-Martinez, Adriana, additional, Roozbehani, Mona, additional, Pou, Sovitj, additional, Nilsen, Aaron, additional, Riscoe, Michael, additional, Doggett, J. Stone, additional, and Hemphill, Andrew, additional
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- 2018
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25. BmGPAC, an Antigen Capture Assay for Detection of Active Babesia microti Infection
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Thekkiniath, Jose, primary, Mootien, Sara, additional, Lawres, Lauren, additional, Perrin, Benjamin A., additional, Gewirtz, Meital, additional, Krause, Peter J., additional, Williams, Scott, additional, Doggett, J. Stone, additional, Ledizet, Michel, additional, and Ben Mamoun, Choukri, additional
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- 2018
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26. Genetic Evidence for Cytochrome b Q i Site Inhibition by 4(1 H )-Quinolone-3-Diarylethers and Antimycin in Toxoplasma gondii
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Alday, P. Holland, primary, Bruzual, Igor, additional, Nilsen, Aaron, additional, Pou, Sovitj, additional, Winter, Rolf, additional, Ben Mamoun, Choukri, additional, Riscoe, Michael K., additional, and Doggett, J. Stone, additional
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- 2017
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27. Radical cure of experimental babesiosis in immunodeficient mice using a combination of an endochin-like quinolone and atovaquone
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Lawres, Lauren A., primary, Garg, Aprajita, additional, Kumar, Vidya, additional, Bruzual, Igor, additional, Forquer, Isaac P., additional, Renard, Isaline, additional, Virji, Azan Z., additional, Boulard, Pierre, additional, Rodriguez, Eduardo X., additional, Allen, Alexander J., additional, Pou, Sovitj, additional, Wegmann, Keith W., additional, Winter, Rolf W., additional, Nilsen, Aaron, additional, Mao, Jialing, additional, Preston, Douglas A., additional, Belperron, Alexia A., additional, Bockenstedt, Linda K., additional, Hinrichs, David J., additional, Riscoe, Michael K., additional, Doggett, J. Stone, additional, and Ben Mamoun, Choukri, additional
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- 2016
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28. SAR Studies of 5-Aminopyrazole-4-carboxamide Analogues as Potent and Selective Inhibitors of Toxoplasma gondii CDPK1
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Huang, Wenlin, primary, Ojo, Kayode K., additional, Zhang, Zhongsheng, additional, Rivas, Kasey, additional, Vidadala, Rama Subba Rao, additional, Scheele, Suzanne, additional, DeRocher, Amy E., additional, Choi, Ryan, additional, Hulverson, Matthew A., additional, Barrett, Lynn K., additional, Bruzual, Igor, additional, Siddaramaiah, Latha Kallur, additional, Kerchner, Keshia M., additional, Kurnick, Matthew D., additional, Freiberg, Gail M., additional, Kempf, Dale, additional, Hol, Wim G. J., additional, Merritt, Ethan A., additional, Neckermann, Georg, additional, de Hostos, Eugenio L., additional, Isoherranen, Nina, additional, Maly, Dustin J., additional, Parsons, Marilyn, additional, Doggett, J. Stone, additional, Van Voorhis, Wesley C., additional, and Fan, Erkang, additional
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- 2015
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29. Bumped Kinase Inhibitor 1294 Treats Established Toxoplasma gondii Infection
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Doggett, J. Stone, primary, Ojo, Kayode K., additional, Fan, Erkang, additional, Maly, Dustin J., additional, and Van Voorhis, Wesley C., additional
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- 2014
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30. An all-sky set of (B)-V-R photometric calibrators for Schmidt surveys. GSPC2.1: First release
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Bucciarelli, B., García Yus, J., Casalegno, R., Postman, M., Lasker, B.M., Sturch, C., Lattanzi, M.G., McLean, B.J., Costa, E., Falasca, A., Le Poole, R., Massone, G., Potter, M., Rosenberg, A., Borgman, T., Doggett, J., Morrison, J., Pizzuti, A., Pompei, E., Rehner, D., Siciliano, L., and Wolfe, D.
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- 2001
31. Sontochin as a Guide to the Development of Drugs against Chloroquine-Resistant Malaria
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Pou, Sovitj, primary, Winter, Rolf W., additional, Nilsen, Aaron, additional, Kelly, Jane Xu, additional, Li, Yuexin, additional, Doggett, J. Stone, additional, Riscoe, Erin W., additional, Wegmann, Keith W., additional, Hinrichs, David J., additional, and Riscoe, Michael K., additional
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- 2012
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32. Lyme Disease in Oregon
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Doggett, J. Stone, primary, Kohlhepp, Sue, additional, Gresbrink, Robert, additional, Metz, Paul, additional, Gleaves, Curt, additional, and Gilbert, David, additional
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- 2008
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33. Progress in Arabidopsis genome sequencing and functional genomics
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UCL - SST/ISV - Institut des sciences de la vie, Wambutt, R, Murphy, G, Volckaert, G, Pohl, T, Düsterhöft, A, Stiekema, W, Entian, K.-D, Terryn, N, Harris, B, Ansorge, W, Brandt, P, Grivell, L, Rieger, M, Weichselgartner, M, de Simone, V, Obermaier, B, Mache, R, Müller, M, Kreis, M, Delseny, M, Puigdomenech, P, Watson, M, Schmidtheini, T, Reichert, B, Portatelle, D, Perez-Alonso, M, Boutry, Marc, Bancroft, I, Vos, P, Hoheisel, J, Zimmermann, W, Wedler, H, Ridley, P, Langham, S.-A, McCullagh, B, Bilham, L, Robben, J, Van der Schueren, J, Grymonprez, B, Chuang, Y.-J, Vandenbussche, F, Braeken, M, Weltjens, I, Voet, M, Bastiaens, I, Aert, R, Defoor, E, Weitzenegger, T, Bothe, G, Ramsperger, U, Hilbert, H, Braun, M, Holzer, E, Brandt, A, Peters, S, van Staveren, M, Dirkse, W, Mooijman, P, Klein Lankhorst, R, Rose, M, Hauf, J, Kötter, P, Berneiser, S, Hempel, S, Feldpausch, M, Lamberth, S, Van den Daele, H, De Keyser, A, Buysshaert, C, Gielen, J, Villarroel, R, De Clercq, R, Van Montagu, M, Rogers, J, Cronin, A, Quail, M, Bray-Allen, S, Clark, L, Doggett, J, Hall, S, Kay, M, Lennard, N, McLay, K, Mayes, R, Pettett, A, Rajandream, M.-A, Lyne, M, Benes, V, Rechmann, S, Borkova, D, Blöcker, H, Scharfe, M, Grimm, M, Löhnert, T.-H, Dose, S, de Haan, M, Maarse, A, Schäfer, M, Müller-Auer, S, Gabel, C, Fuchs, M, Fartmann, B, Granderath, K, Dauner, D, Herzl, A, Neumann, S, Argiriou, A, Vitale, D, Liguori, R, Piravandi, E, Massenet, O, Quigley, F, Clabauld, G, Mündlein, A, Felber, R, Schnabl, S, Hiller, R, Schmidt, W, Lecharny, A, Aubourg, S, Gy, I, Cooke, R, Berger, C, Monfort, A, Casacuberta, E, Gibbons, T, Weber, N, Vandenbol, M, Bargues, M, Terol, J, Torres, A, Perez-Perez, A, Purnelle, B, Bent, E, Johnson, S, Tacon, D, Jesse, T, Heijnen, L, Schwarz, S, Scholler, P, Heber, S, Bielke, C, Frishmann, D, Haase, D, Lemcke, K, Mewes, H.W, Stocker, S, Zaccaria, P, Mayer, K, Schüller, C, Bevan, M, UCL - SST/ISV - Institut des sciences de la vie, Wambutt, R, Murphy, G, Volckaert, G, Pohl, T, Düsterhöft, A, Stiekema, W, Entian, K.-D, Terryn, N, Harris, B, Ansorge, W, Brandt, P, Grivell, L, Rieger, M, Weichselgartner, M, de Simone, V, Obermaier, B, Mache, R, Müller, M, Kreis, M, Delseny, M, Puigdomenech, P, Watson, M, Schmidtheini, T, Reichert, B, Portatelle, D, Perez-Alonso, M, Boutry, Marc, Bancroft, I, Vos, P, Hoheisel, J, Zimmermann, W, Wedler, H, Ridley, P, Langham, S.-A, McCullagh, B, Bilham, L, Robben, J, Van der Schueren, J, Grymonprez, B, Chuang, Y.-J, Vandenbussche, F, Braeken, M, Weltjens, I, Voet, M, Bastiaens, I, Aert, R, Defoor, E, Weitzenegger, T, Bothe, G, Ramsperger, U, Hilbert, H, Braun, M, Holzer, E, Brandt, A, Peters, S, van Staveren, M, Dirkse, W, Mooijman, P, Klein Lankhorst, R, Rose, M, Hauf, J, Kötter, P, Berneiser, S, Hempel, S, Feldpausch, M, Lamberth, S, Van den Daele, H, De Keyser, A, Buysshaert, C, Gielen, J, Villarroel, R, De Clercq, R, Van Montagu, M, Rogers, J, Cronin, A, Quail, M, Bray-Allen, S, Clark, L, Doggett, J, Hall, S, Kay, M, Lennard, N, McLay, K, Mayes, R, Pettett, A, Rajandream, M.-A, Lyne, M, Benes, V, Rechmann, S, Borkova, D, Blöcker, H, Scharfe, M, Grimm, M, Löhnert, T.-H, Dose, S, de Haan, M, Maarse, A, Schäfer, M, Müller-Auer, S, Gabel, C, Fuchs, M, Fartmann, B, Granderath, K, Dauner, D, Herzl, A, Neumann, S, Argiriou, A, Vitale, D, Liguori, R, Piravandi, E, Massenet, O, Quigley, F, Clabauld, G, Mündlein, A, Felber, R, Schnabl, S, Hiller, R, Schmidt, W, Lecharny, A, Aubourg, S, Gy, I, Cooke, R, Berger, C, Monfort, A, Casacuberta, E, Gibbons, T, Weber, N, Vandenbol, M, Bargues, M, Terol, J, Torres, A, Perez-Perez, A, Purnelle, B, Bent, E, Johnson, S, Tacon, D, Jesse, T, Heijnen, L, Schwarz, S, Scholler, P, Heber, S, Bielke, C, Frishmann, D, Haase, D, Lemcke, K, Mewes, H.W, Stocker, S, Zaccaria, P, Mayer, K, Schüller, C, and Bevan, M
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- 2000
34. Organic carbon in Antarctic snow
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Lyons, W. Berry, primary, Welch, Kathleen A., additional, and Doggett, J. Kenneth, additional
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- 2007
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35. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana
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UCL - SST/ISV - Institut des sciences de la vie, Mayer, K., Schüller, C., Wambutt, R., Murphy, G., Volckaert, G., Pohl, T., Düsterhöft, A., Stiekema, W., Entian, K.-D., Terryn, N., Harris, B., Ansorge, W., Brandt, P., Grivell, L., Rieger, M., Weichselgartner, M., de Simone, V., Obermaier, B., Mache, R., Müller, M., Kreis, M., Delseny, M., Puigdomenech, P., Watson, M., Schmidtheini, T., Reichert, B., Portatelle, D., Perez-Alonso, M., Boutry, Marc, Bancroft, I., Vos, P., Hoheisel, J., Zimmermann, W., Wedler, H., Ridley, P., Langham, S.-A., McCullagh, B., Bilham, L., Robben, J., Van der Schueren, J., Grymonprez, B., Chuang, Y.-J., Vandenbussche, F., Braeken, M., Weltjens, I., Voet, M., Bastiaens, I., Aert, R., Defoor, E., Weitzenegger, T., Bothe, G., Ramsperger, U., Hilbert, H., Braun, M., Holzer, E., Brandt, A., Peters, S., van Staveren, M., Dirkse, W., Mooijman, P., Lankhorst, R. Klein, Rose, M., Hauf, J., Kötter, P., Berneiser, S., Hempel, S., Feldpausch, M., Lamberth, S., Van den Daele, H., De Keyser, A., Buysshaert, C., Gielen, J., Villarroel, R., De Clercq, R., Van Montagu, M., Rogers, J., Cronin, A., Quail, M., Bray-Allen, S., Clark, L., Doggett, J., Hall, S., Kay, M., Lennard, N., McLay, K., Mayes, R., Pettett, A., Rajandream, M.-A., Lyne, M., Benes, V., Rechmann, S., Borkova, D., Blöcker, H., Scharfe, M., Grimm, M., Löhnert, T.-H., Dose, S., de Haan, M., Maarse, A., Schäfer, M., Müller-Auer, S., Gabel, C., Fuchs, M., Fartmann, B., Granderath, K., Dauner, D., Herzl, A., Neumann, S., Argiriou, A., Vitale, D., Liguori, R., Piravandi, E., Massenet, O., Quigley, F., Clabauld, G., Mündlein, A., Felber, R., Schnabl, S., Hiller, R., Schmidt, W., Lecharny, A., Aubourg, S., Chefdor, F., Cooke, R., Berger, C., Montfort, A., Casacuberta, E., Gibbons, T., Weber, N., Vandenbol, M., Bargues, M., Terol, J., Torres, A., Perez-Perez, A., Purnelle, B., Bent, E., Johnson, S., Tacon, D., Jesse, T., Heijnen, L., Schwarz, S., Scholler, P., Heber, S., Francs, P., Bielke, C., Frishman, D., Haase, D., Lemcke, K., Mewes, H. W., Stocker, S., Zaccaria, P., Wilson, R. K., de la Bastide, M., Habermann, K., Parnell, L., Dedhia, N., Gnoj, L., Schutz, K., Huang, E., Spiegel, L., Sehkon, M., Murray, J., Sheet, P., Cordes, M., Abu-Threideh, J., Stoneking, T., Kalicki, J., Graves, T., Harmon, G., Edwards, J., Latreille, P., Courtney, L., Cloud, J., Abbott, A., Scott, K., Johnson, D., Minx, P., Bentley, D., Fulton, B., Miller, N., Greco, T., Kemp, K., Kramer, J., Fulton, L., Mardis, E., Dante, M., Pepin, K., Hillier, L., Nelson, J., Spieth, J., Ryan, E., Andrews, S., Geisel, C., Layman, D., Du, H., Ali, J., Berghoff, A., Jones, K., Drone, K., Cotton, M., Joshu, C., Antonoiu, B., Zidanic, M., Strong, C., Sun, H., Lamar, B., Yordan, C., Ma, P., Zhong, J., Preston, R., Vil, D., Shekher, M., Matero, A., Shah, R., Swaby, I'K., O'Shaughnessy, A., Rodriguez, M., Hoffman, J., Till, S., Granat, S., Shohdy, N., Hasegawa, A., Hameed, A., Lodhi, M., Johnson, A., Chen, E., Marra, M., Martienssen, R., McCombie, W. R., UCL - SST/ISV - Institut des sciences de la vie, Mayer, K., Schüller, C., Wambutt, R., Murphy, G., Volckaert, G., Pohl, T., Düsterhöft, A., Stiekema, W., Entian, K.-D., Terryn, N., Harris, B., Ansorge, W., Brandt, P., Grivell, L., Rieger, M., Weichselgartner, M., de Simone, V., Obermaier, B., Mache, R., Müller, M., Kreis, M., Delseny, M., Puigdomenech, P., Watson, M., Schmidtheini, T., Reichert, B., Portatelle, D., Perez-Alonso, M., Boutry, Marc, Bancroft, I., Vos, P., Hoheisel, J., Zimmermann, W., Wedler, H., Ridley, P., Langham, S.-A., McCullagh, B., Bilham, L., Robben, J., Van der Schueren, J., Grymonprez, B., Chuang, Y.-J., Vandenbussche, F., Braeken, M., Weltjens, I., Voet, M., Bastiaens, I., Aert, R., Defoor, E., Weitzenegger, T., Bothe, G., Ramsperger, U., Hilbert, H., Braun, M., Holzer, E., Brandt, A., Peters, S., van Staveren, M., Dirkse, W., Mooijman, P., Lankhorst, R. Klein, Rose, M., Hauf, J., Kötter, P., Berneiser, S., Hempel, S., Feldpausch, M., Lamberth, S., Van den Daele, H., De Keyser, A., Buysshaert, C., Gielen, J., Villarroel, R., De Clercq, R., Van Montagu, M., Rogers, J., Cronin, A., Quail, M., Bray-Allen, S., Clark, L., Doggett, J., Hall, S., Kay, M., Lennard, N., McLay, K., Mayes, R., Pettett, A., Rajandream, M.-A., Lyne, M., Benes, V., Rechmann, S., Borkova, D., Blöcker, H., Scharfe, M., Grimm, M., Löhnert, T.-H., Dose, S., de Haan, M., Maarse, A., Schäfer, M., Müller-Auer, S., Gabel, C., Fuchs, M., Fartmann, B., Granderath, K., Dauner, D., Herzl, A., Neumann, S., Argiriou, A., Vitale, D., Liguori, R., Piravandi, E., Massenet, O., Quigley, F., Clabauld, G., Mündlein, A., Felber, R., Schnabl, S., Hiller, R., Schmidt, W., Lecharny, A., Aubourg, S., Chefdor, F., Cooke, R., Berger, C., Montfort, A., Casacuberta, E., Gibbons, T., Weber, N., Vandenbol, M., Bargues, M., Terol, J., Torres, A., Perez-Perez, A., Purnelle, B., Bent, E., Johnson, S., Tacon, D., Jesse, T., Heijnen, L., Schwarz, S., Scholler, P., Heber, S., Francs, P., Bielke, C., Frishman, D., Haase, D., Lemcke, K., Mewes, H. W., Stocker, S., Zaccaria, P., Wilson, R. K., de la Bastide, M., Habermann, K., Parnell, L., Dedhia, N., Gnoj, L., Schutz, K., Huang, E., Spiegel, L., Sehkon, M., Murray, J., Sheet, P., Cordes, M., Abu-Threideh, J., Stoneking, T., Kalicki, J., Graves, T., Harmon, G., Edwards, J., Latreille, P., Courtney, L., Cloud, J., Abbott, A., Scott, K., Johnson, D., Minx, P., Bentley, D., Fulton, B., Miller, N., Greco, T., Kemp, K., Kramer, J., Fulton, L., Mardis, E., Dante, M., Pepin, K., Hillier, L., Nelson, J., Spieth, J., Ryan, E., Andrews, S., Geisel, C., Layman, D., Du, H., Ali, J., Berghoff, A., Jones, K., Drone, K., Cotton, M., Joshu, C., Antonoiu, B., Zidanic, M., Strong, C., Sun, H., Lamar, B., Yordan, C., Ma, P., Zhong, J., Preston, R., Vil, D., Shekher, M., Matero, A., Shah, R., Swaby, I'K., O'Shaughnessy, A., Rodriguez, M., Hoffman, J., Till, S., Granat, S., Shohdy, N., Hasegawa, A., Hameed, A., Lodhi, M., Johnson, A., Chen, E., Marra, M., Martienssen, R., and McCombie, W. R.
- Abstract
The higher plant Arabidopsis thaliana (Arabidopsis) is an important model for identifying plant genes and determining their function. To assist biological investigations and to define chromosome structure, a coordinated effort to sequence the Arabidopsis genome was initiated in late 1996. Here we report one of the first milestones of this project, the sequence of chromosome 4. Analysis of 17.38 megabases of unique sequence, representing about 17% of the genome, reveals 3,744 protein coding genes, 81 transfer RNAs and numerous repeat elements. Heterochromatic regions surrounding the putative centromere, which has not yet been completely sequenced, are characterized by an increased frequency of a variety of repeats, new repeats, reduced recombination, lowered gene density and lowered gene expression. Roughly 60% of the predicted protein-coding genes have been functionally characterized on the basis of their homology to known genes. Many genes encode predicted proteins that are homologous to human and Caenorhabditis elegans proteins.
- Published
- 1999
36. An all-sky set of $\vec (B)-V-R$ photometric calibrators for Schmidt surveys
- Author
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Bucciarelli, B., primary, García Yus, J., additional, Casalegno, R., additional, Postman, M., additional, Lasker, B. M., additional, Sturch, C., additional, Lattanzi, M. G., additional, McLean, B. J., additional, Costa, E., additional, Falasca, A., additional, Le Poole, R., additional, Massone, G., additional, Potter, M., additional, Rosenberg, A., additional, Borgman, T., additional, Doggett, J., additional, Morrison, J., additional, Pizzuti, A., additional, Pompei, E., additional, Rehner, D., additional, Siciliano, L., additional, and Wolfe, D., additional
- Published
- 2001
- Full Text
- View/download PDF
37. An all-sky set of $\vec (B)-V-R$photometric calibrators for Schmidt surveys*
- Author
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Bucciarelli, B., García Yus, J., Casalegno, R., Postman, M., Lasker, B. M., Sturch, C., Lattanzi, M. G., McLean, B. J., Costa, E., Falasca, A., Poole, R. Le, Massone, G., Potter, M., Rosenberg, A., Borgman, T., Doggett, J., Morrison, J., Pizzuti, A., Pompei, E., Rehner, D., Siciliano, L., Wolfe, D., Bucciarelli, B., García Yus, J., Casalegno, R., Postman, M., Lasker, B. M., Sturch, C., Lattanzi, M. G., McLean, B. J., Costa, E., Falasca, A., Poole, R. Le, Massone, G., Potter, M., Rosenberg, A., Borgman, T., Doggett, J., Morrison, J., Pizzuti, A., Pompei, E., Rehner, D., Siciliano, L., and Wolfe, D.
- Abstract
We publish 622 CCD photometric sequences in the Johnson-Kron-Cousins standard system, distributed both in the northern and southern hemispheres, useful for the calibration of photographic photometry of Schmidt survey plates. The collection and reduction of the CCD data presented here are part of a long-term program devoted to the construction of the Second Guide Star Photometric Catalog (GSPC-II). The GSPC-II is an all-sky catalog of photometric stellar sequences with a limiting magnitude of $V=19$or fainter, in the $(B)$, V, and Rpassbands of the Johnson-Kron-Cousins system. Standard photometric errors are at the level of ∼0.07 for a $V \sim 19$magnitude star. These sequences are being used by teams of the Space Telescope Science Institute (STScI) and the Osservatorio Astronomico of Torino (OATo) for the photometric calibration of the Second Guide Star Catalog.
- Published
- 2001
- Full Text
- View/download PDF
38. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana
- Author
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Mayer, K., primary, Schüller, C., additional, Wambutt, R., additional, Murphy, G., additional, Volckaert, G., additional, Pohl, T., additional, Düsterhöft, A., additional, Stiekema, W., additional, Entian, K.-D., additional, Terryn, N., additional, Harris, B., additional, Ansorge, W., additional, Brandt, P., additional, Grivell, L., additional, Rieger, M., additional, Weichselgartner, M., additional, de Simone, V., additional, Obermaier, B., additional, Mache, R., additional, Müller, M., additional, Kreis, M., additional, Delseny, M., additional, Puigdomenech, P., additional, Watson, M., additional, Schmidtheini, T., additional, Reichert, B., additional, Portatelle, D., additional, Perez-Alonso, M., additional, Boutry, M., additional, Bancroft, I., additional, Vos, P., additional, Hoheisel, J., additional, Zimmermann, W., additional, Wedler, H., additional, Ridley, P., additional, Langham, S.-A., additional, McCullagh, B., additional, Bilham, L., additional, Robben, J., additional, Van der Schueren, J., additional, Grymonprez, B., additional, Chuang, Y.-J., additional, Vandenbussche, F., additional, Braeken, M., additional, Weltjens, I., additional, Voet, M., additional, Bastiaens, I., additional, Aert, R., additional, Defoor, E., additional, Weitzenegger, T., additional, Bothe, G., additional, Ramsperger, U., additional, Hilbert, H., additional, Braun, M., additional, Holzer, E., additional, Brandt, A., additional, Peters, S., additional, van Staveren, M., additional, Dirkse, W., additional, Mooijman, P., additional, Lankhorst, R. Klein, additional, Rose, M., additional, Hauf, J., additional, Kötter, P., additional, Berneiser, S., additional, Hempel, S., additional, Feldpausch, M., additional, Lamberth, S., additional, Van den Daele, H., additional, De Keyser, A., additional, Buysshaert, C., additional, Gielen, J., additional, Villarroel, R., additional, De Clercq, R., additional, Van Montagu, M., additional, Rogers, J., additional, Cronin, A., additional, Quail, M., additional, Bray-Allen, S., additional, Clark, L., additional, Doggett, J., additional, Hall, S., additional, Kay, M., additional, Lennard, N., additional, McLay, K., additional, Mayes, R., additional, Pettett, A., additional, Rajandream, M.-A., additional, Lyne, M., additional, Benes, V., additional, Rechmann, S., additional, Borkova, D., additional, Blöcker, H., additional, Scharfe, M., additional, Grimm, M., additional, Löhnert, T.-H., additional, Dose, S., additional, de Haan, M., additional, Maarse, A., additional, Schäfer, M., additional, Müller-Auer, S., additional, Gabel, C., additional, Fuchs, M., additional, Fartmann, B., additional, Granderath, K., additional, Dauner, D., additional, Herzl, A., additional, Neumann, S., additional, Argiriou, A., additional, Vitale, D., additional, Liguori, R., additional, Piravandi, E., additional, Massenet, O., additional, Quigley, F., additional, Clabauld, G., additional, Mündlein, A., additional, Felber, R., additional, Schnabl, S., additional, Hiller, R., additional, Schmidt, W., additional, Lecharny, A., additional, Aubourg, S., additional, Chefdor, F., additional, Cooke, R., additional, Berger, C., additional, Montfort, A., additional, Casacuberta, E., additional, Gibbons, T., additional, Weber, N., additional, Vandenbol, M., additional, Bargues, M., additional, Terol, J., additional, Torres, A., additional, Perez-Perez, A., additional, Purnelle, B., additional, Bent, E., additional, Johnson, S., additional, Tacon, D., additional, Jesse, T., additional, Heijnen, L., additional, Schwarz, S., additional, Scholler, P., additional, Heber, S., additional, Francs, P., additional, Bielke, C., additional, Frishman, D., additional, Haase, D., additional, Lemcke, K., additional, Mewes, H. W., additional, Stocker, S., additional, Zaccaria, P., additional, Bevan, M., additional, Wilson, R. K., additional, de la Bastide, M., additional, Habermann, K., additional, Parnell, L., additional, Dedhia, N., additional, Gnoj, L., additional, Schutz, K., additional, Huang, E., additional, Spiegel, L., additional, Sehkon, M., additional, Murray, J., additional, Sheet, P., additional, Cordes, M., additional, Abu-Threideh, J., additional, Stoneking, T., additional, Kalicki, J., additional, Graves, T., additional, Harmon, G., additional, Edwards, J., additional, Latreille, P., additional, Courtney, L., additional, Cloud, J., additional, Abbott, A., additional, Scott, K., additional, Johnson, D., additional, Minx, P., additional, Bentley, D., additional, Fulton, B., additional, Miller, N., additional, Greco, T., additional, Kemp, K., additional, Kramer, J., additional, Fulton, L., additional, Mardis, E., additional, Dante, M., additional, Pepin, K., additional, Hillier, L., additional, Nelson, J., additional, Spieth, J., additional, Ryan, E., additional, Andrews, S., additional, Geisel, C., additional, Layman, D., additional, Du, H., additional, Ali, J., additional, Berghoff, A., additional, Jones, K., additional, Drone, K., additional, Cotton, M., additional, Joshu, C., additional, Antonoiu, B., additional, Zidanic, M., additional, Strong, C., additional, Sun, H., additional, Lamar, B., additional, Yordan, C., additional, Ma, P., additional, Zhong, J., additional, Preston, R., additional, Vil, D., additional, Shekher, M., additional, Matero, A., additional, Shah, R., additional, Swaby, I'K., additional, O'Shaughnessy, A., additional, Rodriguez, M., additional, Hoffman, J., additional, Till, S., additional, Granat, S., additional, Shohdy, N., additional, Hasegawa, A., additional, Hameed, A., additional, Lodhi, M., additional, Johnson, A., additional, Chen, E., additional, Marra, M., additional, Martienssen, R., additional, and McCombie, W. R., additional
- Published
- 1999
- Full Text
- View/download PDF
39. Drugs in development for toxoplasmosis: advances, challenges, and current status
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Alday PH and Doggett JS
- Subjects
Toxoplasma gondii ,therapeutics ,preclinical medicine ,experimental medicine ,mechanism of action ,Apicomplexa ,Therapeutics. Pharmacology ,RM1-950 - Abstract
P Holland Alday,1 Joseph Stone Doggett1,2 1Division of Infectious Diseases, Oregon Health & Science University, 2Portland Veterans Affairs Medical Center, Portland, OR, USA Abstract: Toxoplasma gondii causes fatal and debilitating brain and eye diseases. Medicines that are currently used to treat toxoplasmosis commonly have toxic side effects and require prolonged courses that range from weeks to more than a year. The need for long treatment durations and the risk of relapsing disease are in part due to the lack of efficacy against T. gondii tissue cysts. The challenges for developing a more effective treatment for toxoplasmosis include decreasing toxicity, achieving therapeutic concentrations in the brain and eye, shortening duration, eliminating tissue cysts from the host, safety in pregnancy, and creating a formulation that is inexpensive and practical for use in resource-poor areas of the world. Over the last decade, significant progress has been made in identifying and developing new compounds for the treatment of toxoplasmosis. Unlike clinically used medicines that were repurposed for toxoplasmosis, these compounds have been optimized for efficacy against toxoplasmosis during preclinical development. Medicines with enhanced efficacy as well as features that address the unique aspects of toxoplasmosis have the potential to greatly improve toxoplasmosis therapy. This review discusses the facets of toxoplasmosis that are pertinent to drug design and the advances, challenges, and current status of preclinical drug research for toxoplasmosis. Keywords: Toxoplasma gondii, therapeutics, preclinical medicine, experimental medicine, mechanism of action, Apicomplexa
- Published
- 2017
40. To a Lock of Hair
- Author
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Doggett, J., Jr., Doggett, J., Jr., Doggett, J., Jr., and Doggett, J., Jr.
- Abstract
Southern literary messenger; devoted to every department of literature and the fine arts. / Volume 2, Issue 8, Page(s) 464, (dlps) volume: acf2679.0002.008, (dlps) article: acf2679.0002.008:2, http://quod.lib.umich.edu/t/text/accesspolicy.html
41. Effective Therapy Targeting Cytochrome bc1Prevents BabesiaErythrocytic Development and Protects from Lethal Infection
- Author
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Chiu, Joy E., Renard, Isaline, Pal, Anasuya C., Singh, Pallavi, Vydyam, Pratap, Thekkiniath, Jose, Kumar, Madelyn, Gihaz, Shalev, Pou, Sovitj, Winter, Rolf W., Dodean, Rozalia, Frueh, Lisa, Nilsen, Aaron C., Riscoe, Michael K., Doggett, J. Stone, and Mamoun, Choukri Ben
- Abstract
An effective strategy to control blood-borne diseases and prevent outbreak recrudescence involves targeting conserved metabolic processes that are essential for pathogen viability. One such target for Plasmodiumand Babesia, the infectious agents of malaria and babesiosis, respectively, is the mitochondrial cytochrome bc1protein complex, which can be inhibited by endochin-like quinolones (ELQ) and atovaquone.
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- 2021
- Full Text
- View/download PDF
42. Orally Bioavailable Endochin-Like Quinolone Carbonate Ester Prodrug Reduces Toxoplasma gondiiBrain Cysts
- Author
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Doggett, J. Stone, Schultz, Tracey, Miller, Alyssa J., Bruzual, Igor, Pou, Sovitj, Winter, Rolf, Dodean, Rozalia, Zakharov, Lev N., Nilsen, Aaron, Riscoe, Michael K., and Carruthers, Vern B.
- Published
- 2020
- Full Text
- View/download PDF
43. Activities of Endochin-Like Quinolones Against in vitro Cultured Besnoitia besnoiti Tachyzoites
- Author
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Eberhard, Naja, Balmer, Vreni, Müller, Joachim, Müller, Norbert, Winter, Rolf, Pou, Soviti, Nilsen, Aaron, Riscoe, Mike, Francisco, Samuel, Leitao, Alexandre, Doggett, J Stone, and Hemphill, Andrew
- Subjects
630 Agriculture ,parasitic diseases ,3. Good health - Abstract
Endochin-like quinolones (ELQs) potently inhibit the proliferation of Plasmodium, Toxoplasma, Neospora, and Babesia by targeting the cytochrome b Qo and Qi sites and interfering with oxidative phosphorylation and pyrimidine biosynthesis. The activities of 14 different ELQs were assessed against B. besnoiti tachyzoites grown in human foreskin fibroblasts (HFF) by quantitative real time PCR. The values for 50% proliferation inhibition (IC50) of five ELQs were determined in a 3-days growth assay after an initial screen of 12 ELQs at 0.01, 0.1, and 1 μM. The IC50s of ELQ-121, -136, and -316 were 0.49, 2.36, and 7.97 nM, respectively. The IC50s of ELQs tested against B. besnoiti were higher than IC50s previously observed for P. falciparum and T. gondii. However, the B. besnoiti cytochrome b sequence and the predicted Qo and Qi ELQ binding sites in the Toxoplasma, Neospora, and Besnoitia cytochrome b are virtually identical, suggesting that the differences in ELQ susceptibility are not due to variations in the substrate binding sites. TEM of ELQ-treated parasites primarily demonstrated alterations within the parasite mitochondrion, profound thickening of the nuclear membrane, as well as increased vacuolization within the tachyzoite cytoplasm. Long-term treatment assays of intracellular B. besnoiti with ELQs for up to 20 days followed by the release of drug pressure caused a substantial delay in parasite growth and proliferation while ELQs were present, but parasite proliferation resumed days after ELQs were removed. Interestingly, structural alterations persisted after ELQ removal and parasite proliferation was slowed. These findings provide a basis for further in vivo studies of ELQs as therapeutic options against B. besnoiti infection.
44. In vitro activity, safety and in vivo efficacy of the novel bumped kinase inhibitor BKI-1748 in non-pregnant and pregnant mice experimentally infected with Neospora caninum tachyzoites and Toxoplasma gondii oocysts
- Author
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Imhof, Dennis, Anghel, Nicoleta, Winzer, Pablo, Balmer, Vreni, Ramseier, Jessica, H��nggeli, Kai, Choi, Ryan, Hulverson, Matthew A, Whitman, Grant R, Arnold, Samuel L M, Ojo, Kayode K, Van Voorhis, Wesley C, Doggett, J Stone, Ortega-Mora, Luis M, and Hemphill, Andrew
- Subjects
630 Agriculture ,parasitic diseases ,570 Life sciences ,biology ,500 Science ,3. Good health - Abstract
Bumped kinase inhibitors (BKIs) target the apicomplexan calcium-dependent protein kinase 1 (CDPK1). BKI-1748, a 5-aminopyrazole-4-carboxamide compound when added to fibroblast cells concomitantly to the time of infection, inhibited proliferation of apicomplexan parasites at EC50s of 165��nM (Neospora caninum) and 43��nM (Toxoplasma gondii). Immunofluorescence and electron microscopy showed that addition of 2.5����M BKI-1748 to infected HFF monolayers transformed parasites into multinucleated schizont-like complexes (MNCs) containing newly formed zoites, which were unable to separate and form infective tachyzoites or undergo egress. In zebrafish (Danio rerio) embryo development assays, no embryonic impairment was detected within 96��h at BKI-1748 concentrations up to 10����M. In pregnant mice, BKI-1748 applied at days 9-13 of pregnancy at a dose of 20��mg/kg/day was safe and no pregnancy interference was observed. The efficacy of BKI-1748 was assessed in standardized pregnant mouse models infected with N. caninum (NcSpain-7) tachyzoites or T. gondii (TgShSp1) oocysts. In both models, treatments resulted in increased pup survival and profound inhibition of vertical transmission. However, in dams and non-pregnant mice, BKI-1748 treatments resulted in significantly decreased cerebral parasite loads only in T. gondii infected mice. In the T. gondii-model, ocular infection was detected in 10 out of 12 adult mice of the control group, but only in 3 out of 12 mice in the BKI-1748-treated group. Thus, TgShSp1 oocyst infection is a suitable model to study both cerebral and ocular infection by T. gondii. BKI-1748 represents an interesting candidate for follow-up studies on neosporosis and toxoplasmosis in larger animal models.
45. Antiinflammatory therapy with canakinumab for atherosclerotic disease
- Author
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Ridker P.M., Everett B.M., Thuren T., MacFadyen J.G., Chang W.H., Ballantyne C., Fonseca F., Nicolau J., Koenig W., Anker S.D., Kastelein J.J.P., Cornel J.H., Pais P., Pella D., Genest J., Cifkova R., Lorenzatti A., Forster T., Kobalava Z., Vida-Simiti L., Flather M., Shimokawa H., Ogawa H., Dellborg M., Rossi P.R.F., Troquay R.P.T., Libby P., Glynn R.J., Krum H., Varigos J., Siostrzonek P., Sinnaeve P., Gotcheva N., Yong H., Urina-Triana M., Milicic D., Vettus R., Manolis A.J., Wyss F., Sigurdsson A., Fucili A., Veze I., Petrauskiene B., Salvador L., Klemsdal T.O., Medina F., Budaj A., Otasevic P., Lainscak M., Seung K.B., Commerford P., Donath M., Hwang J.J., Kultursay H., Bilazarian S., East C., Forgosh L., Harris B., Ligueros M., Bohula E., Charmarthi B., Cheng S., Chou S., Danik J., McMahon G., Maron B., Ning M., Olenchock B., Pande R., Perlstein T., Pradhan A., Rost N., Singhal A., Taqueti V., Wei N., Burris H., Cioffi A., Dalseg A.M., Ghosh N., Gralow J., Mayer T., Rugo H., 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Siemann M., Stern M., Toom M., Vahula V., Apel T., Axthelm C., Ayasse D., Ayasse M., Baar M., Baeumer A., Bagi E.S., Becker B., Binder A., Blankenberg S., Braun P., Johansen B.B., Contzen C., Delfonso F., Denecke C., Dengler T., Donaubauer T., Eichinger G., Englmann E., Erhard M., Faghih M., Foerster A., Frankenstein L., Fuchs R., Furch G., Gaeb-Strasas B., Germann H., Giese C., Goette A., Gravenhorst-Muenter U., Haege R., Haenel T., Hagemann D., Hagenow A., Hanefeld M., Heider J., Heisters J., Hennig D., Hielscher S., Himpel-Boenninghoff A., Holscher A., Hornig M., Jeserich M., Kaczmarek N., Kanitz S., Kara Y.D., Khariouzov A., Kiefer R., Kiroglu K., Klamm M., Klein C., Korth-Wiemann B., Krapivsky A., Kuenzler J., Kuntzsch A., Landers B., Lappo M., Laube S., Leggewie S., Lehmann D., Lepp H., Lierse T., Lindner C., Luecke-Uzar M., Luedemann J., Marschke T., Maruzzo S., Mauersberger K., Maus O., Meinrich M., Meissner A., Moehring B., Muehlhaus J., Mueller S., Muenter K.C., Muenzel T., 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Bevilacqua M.T., Bolognesi M.G., Dessalvi C.C., Calabrese A., Campanale E.G., Candusso R., Caso P., Cosmi F., Crea F., Crocamo A., De Caterina R., De Rosa S., Destro M., Di Biase M., Dognini G.P., Eleuteri E., Fedele F., Ferrario M., Gabrielli D., Gamba C., Ganau A., Gravellone M., Iannopollo G., Indolfi C., Infusino F., Invitti C., Landolfi A., Lembo G., Liberato N.L., Mannucci E., Marino P., Mariottoni B., Marziali A., Mercuro G., Monti L., Mos L., Mureddu V., Musumeci M.B., Novo S., Panzarino C., Parente A., Perotti M., Filardi P.P., Petrillo C., Piatti P., Priori S., Racca V., Ragghianti B., Renda G., Righini V., Sarcone M., Senni M., Soro E., Tamburrini P., Vallone L., Villani G.Q., Volpe M., Ajioka M., Akai Y., Ashino K., Baden M., Doi M., Eki Y., Endo T., Fukuike C., Hagiwara Y., Hasegawa K., Higuchi Y., Higuchi T., Hioki M., Hirayama A., Hiroma J., Hosokawa S., Ichisawa M., Iijima T., Inada T., Inagaki M., Ito K., Kaigawa K., Kajihara S., Kamiya H., Kamiya J., Kaneno Y., Katahira K., Kataoka M., Kawai M., Kawasaki T., Kojima E., Komura Y., Kuramochi T., Kuruma T., Kyo E., Mani H., Miyamoto T., Morii I., Morinaga Y., Morisawa T., Nagai Y., Naka T., Nakamura Y., Nakamura S., Nakayoshi K., Nishibe A., Ogawa M., Okada Y., Okawa M., Sakamoto Y., Sakurada M., Sasaki S., Seki S., Shimomura H., Shinozaki T., Sugimoto N., Suzuki A., Taguchi S., Takahashi J., Takase S., Tanabe K., Tanaka A., Tani S., Tomioka J., Tsuboi H., Tsuji M., Tsujita K., Tsujiyama S., Umesu A., Yamada T., Yamaguchi E., Yamamoto H., Yamamoto T., Yamane M., Yanase T., Yasuoka S., Yasutake M., Yokoyama M., Yoshida M., Yoshimoto E., Yunoki C., Balode A., Dormidontova G., Flaksa I., Nagele-Luse I., Rancane G., Sime I., Bartuseviciene S., Cepinskiene L., Dobilas V., Grigaraviciene I., Marcinkeviciene J., Mazutavicius R., Miliuniene R., Motiejuniene R., Norkiene S., Norkute-Macijauske U., Rudys A., Slapikas R., Stonkute K., Strazdiene D., Tijuneliene E., Urbonas G., Vanagiene S., Viezelis M., 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W., Caballero-Valiente B., Carr K., Halliwell T.C., Castillo J., Cei L., Cerda L., Chambers J., Chamblee T., Chattin W., Chee L., Chen Y.C., Cherlin R., Cheung D., Chiodi L., Christensen L., Christenson S., Cislowski D., Clavier-Firmin C., Colfer H., Colvin T., Cosgrove N., Covert C., Cox B., Cox R., Craig W., Crandall L., Crepps K., Cromer M., Cruz H., Cruz M., Cucher F., Damron M., Dave K., Dave B., Davis M., Davis B., Dawkins-Hughes S., Dean J., Debnam S., Defosse C., Dehning M., Dela Llana A., Dellorso M., Denham D., Desalle D., Dettmer M., Dhawan M., Diago M., Dicken T., Diederich C., Diederich M., Diehl R., Digangi D., Diller P., Dimattia M., Dodds G., Doggett J., Donahue K., Doughty L., Dragutksy B., Dreese M., Dunhurst F., Dunn D., Dutka C., Earl J., Eaton C., Eaves W., Ebeling K., Eder F., Edgerton L., Edillo C., Edwards J., Edwards T., Einhorn D., El Hafi S., Ellis M., Erickson B., Ervin W., Eskridge L., Fail P., Falcon D., Fang C., Fattal P., Fawson A., Felix L., Ferdinand 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D.H., Hotchkiss D., Huang P., Humbert J., Hutchens E., Iachini K., Ibarra M., Igbokidi O., Ilahi T., Imbrognio M., Ipp E., Iteld B., Jacques G., Jafri A., Jafry B., Jardula M., Jefferson D., Jenkins R., Johnson E., Johnson J., Jones S., Kawahara M., Kelehan S., Kelly R., Kendall T., Kereiakes D., Khan M., Khan S., Kick J., Kimmel M., King T., King A., Kirkland S., Kissel S., Kitchens D., Klein P., Klugherz B., Korban E., Koren M., Korte M., Kostis J., Kotek L., Kozak M., Kreutter F., Kusnick B., Labovitz R., Lail J., Lamance J., Lamas G., Lambert J., Lambert C., Landzberg J., Langdon J., Lavoie W., Ledger G., Lee T., Lehman R., Leimbach W., Lennard M., Lepor N., Lester F., Levin P., Levinson L., Lewis D., Lillo J., Link L., Long C., Longaker R., Lorch G., Lucksinger G., Lynd S., Rhudy J.M., Madder R., Magness K., Maheshwari A., Alan A., Malek M., Maletz L., Malhotra V., Malhotra S., Mandviwala M., Mani C.K., Manuel J., Marchelletta N., Marshall L., Marsters M., Martin L., Martinez E., Mavromatis K., Maynard R., Mays M., Mays B., Mbulaiteye A., Mcalister R., Mccoy C., Mccrary D.Jr., Mccullough-O'Brien H., Mcdonald M., Mcgill J., Mcgrew F., Mckenzie C., Mclaurin B., Mclellan B.A., Mcneil D., Mcneill R., Mehrle A., Melbie K., Melliza T., Messina T., Meyer R., Michel K., Mikdadi G., Miller C., Miller R., Miller A., Miller G., Miller W., Mitchell J., Moats DJR., Mody F., Moffat J., Molk B., Molter D., Monroe T., Montero H., Montgomery R., Mookherjee D., Moran J., Moriarty P., Morrison J., Morton D., Moshayedi P., Mosley J., Moustafa M., Munshi K., Murray A., Mustafa J., Nadar V., Naidu R., Nalley J., Navy S., Neil L., Neutel J.M., Niblack P., Nicely V., Nicolai M., Nijmeh G., Nikas A., Nikyar A., Nixon S., Norman L., Noto G., Nour K., Nugent A., Ocman B., Odegard A., Olsen S., Ortiz-Carrasquillo R., Ossino N., Paez H., Palchick B., Paliwal Y., Pannell R., Parfait V., Partridge J., Patel B., Patel M., Patel S., Paysor C., Pena A., Pereira S., Perez M., Perez A., Perkins H., Perry B., Peters P., Phillippi C., Phillips A., Piacente R., Pintado M., Pish R., Pitt W., Poling T., Pomposini D., Poock J., Potts J., Poudrier R., Prior J., Pritchard C., Purighalla R., Quddusi K., Quinones J., Quinton D., Radin M., Radojcsics B., Rajput B., Rama B., Ramos M., Rauch R., Raynes K., Reber A.M., Reddy J., Reeves M., Reilly K., Renaud K., Resnick H., Reyes R., Richardson M., Riethof M., Riser J., Rodero M., Rodriguez Araya E., Roper L., Rozeman P., Ruder D., Runquist L., Sack G., Saint-Jacques H., Salfity M., Sall N., Sam K., Samal A., Sanchez D., Santiago J.Jr., Savignano C., Saylor R., Scheffel M., Schifferdecker B., Schindler E., Schneider P., Schneider R., Schnitzler R., Schrager B., Schwartz A., Scott R., Seals A., Shah A.V., Shah A., Shatsky K., Shayani S., Shealy N., Sheets L., Shelley J., Shepard P., Shetty S., Silver K., Simon M., Singh K., Singh N., Sizemore B.C., Skatrud L., Slayton C., Slimak V., Sloane G., Smallwood B., Smith P., Smith M., Smith T., Smith G., Smith B., Smith J., Soca Y., Sofley C., Sopko K., Sosa-Padilla M., Sotolongo R., Sprinkle B., Srivastava S., Starzec M., Steinhoff J., Stelly L., Stinson J., Stoddard M., Stoltz S., Stone B., Stover T., Strain J., Strugatsky S., Stys T., Suleman A., Sullivan P., Tamez W., Tandon N., Teltser M., Terry P.S., Terry K., Tessmar C., Thekkoott D., Thomas D., Thomas D.M., Thompson E., Thompson J., Thornton A., Tjaden T., Tobias C., Topper J., Tran A., Treasure C., Trenkamp P., Trevino M., Tsou L., Tuholske C., Uy W., Vahtel M., Vaid B., Valenzuela M., Vance A., Vandam J., Vanhecke T., Vanness WC III., Vargas R., Vaz S., Vazquez Tanus J., Veerina K., Vega J., Vento A., Vijay N., Voelker F., Vogt E., Vold D., Vora K., Wade R.D., Wadell C., Waksman R., Walker K., Wallace K., Warren M., Washam M., Watson B., Webel R., Wells T., West M., Whitaker J., White J., White C., White A., Wilhoit G., Wilkins M., Willingham K., Wilson S., Wilson V., Wise J., Woodall S., Woods A., Wright J., Xu 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Taqueti V., Wei N., Burris H., Cioffi A., Dalseg A.M., Ghosh N., Gralow J., Mayer T., Rugo H., Fowler V., Limaye A.P., Cosgrove S., Levine D., Lopes R., Scott J., Hilkert R., Tamesby G., Mickel C., Manning B., Woelcke J., Tan M., Manfreda S., Ponce T., Kam J., Saini R., Banker K., Salko T., Nandy P., Tawfik R., O’Neil G., Manne S., Jirvankar P., Lal S., Nema D., Jose J., Collins R., Bailey K., Blumenthal R., Colhoun H., Gersh B., Abreu M., Actis M.V., Aiub J., Aiub F., Albisu J., Alvarisqueta A., Avalos V., Barreto M., Berli M.A., Blumberg C., Bocanera M., Botta C., Bowen L., Budassi N., Buhlman S., Westberg J.C., Carabajal T., Caruso G., Casala J., Cendali G., Coloma G., Berra F.C., Cuneo C., Degennaro N., Dellasa M., Diaz M., Dos Santos P., Espinosa V., Facello A., Facello M., Farias E., Fernandez A.A., Ferrari V., Pacora F.F., Flores G.S., Franco M., Gabito A., Viola H.G., Garcia F., Garcia Duran R., Garcia Pinna J., Glenny J., Godoy Sanchez M., Grosse A., Guzman P., Hasbani E., Hominal M., Ibañez J., Jure H., Jure D., Vico M.L., Liniado G., Luciardi H., Luquez H., Maehara G., Maffei L., Majul C., Mallagray M., Marinaro S., Martinez J., Massaccesi R., De Los Milagros Had M., Azize G.M., Montana O., Montenegro E., Morell Y., Muntaner J., Navarrete S., Olmedo M., Paganini M., Paz S., Perez Manghi F., Piskorz D., Polato C., Recoaro R., Romano A., Salinger M., Sanchez A., Saravia M.A., Sarjanovich R., Scaro G., Schiavi L.B., Soler J., Tinnirello V., Tomassi A., Valle M., Vallejo M.A., Venturini C., Marcela Wenetz L.M., Yossen M., Zaidman C., Zalazar L., Zangroniz P., Amerena J., Brady L., Colquhoun D., Eccleston D., Ferreira-Jardim A., French J., Jayasinghe R., Mcintosh C., Ord M., Plotz M., Purnell P., Roberts-Thomson P., Schultz C., Shanahan T., Tan R., Taverner P., Turner F., Vibert J., Vorster M., William M., Youssef G., Bergler-Klein J., Brath H., Brodmann M., Fliesser-Goerzer E., Haider K., Heeren G., Hiden C., Mandic L., Paulweber B., Ploechl A., Prenner A., Steringer-Mascherbauer R., Strohner-Kaestenbauer H., Barbato E., Bouvy C., Briké C., Charlier F., Cools F., De Knijf K., De Wolf L., Delforge M., Deweerdt N., Gits F., Goffinet C., Hermans K., Hollanders G., Mestdagh I., Pirenne B., Servaes V., Simons N., Tahon S., Theunissen E., Van Genechten G., Vervoort G., Vissers C., Vranckx P., Vrolix M., Abib E.Jr., Abrantes J., Araujo Fonseca M., Barbosa E., Barroso W., Barroso A., Bodanese L., Botelho R., Costa Amorim R., Da Costa F., Da Silva A., Da Silva O.Jr., Da Silva D.Jr., Ferreira Dos Santos T., Dos Santos F., Dos Santos A., Duda N., Feitosa G., Felario Junior GA., Ferraz R., Filho P., Fonseca A., Wanderley F.F., Freitas E., Fucci F., Marengo Garcia De Carvalho L., Hernandez M., Hettwer Magedanz E., Julião K., Kormann A., Lameira A., Lima F., Lino E., Maia L., Manenti E., Marchi A.L., Fischer S.M., Michalaros Y., Moraes J.Jr., Moreira L., Pagnan M., Pesce F., Pinheiro L., Rassi S., Reis G., Reis H., Resende I., Roel A., Ruschel K., Saporito W., Saraiva J.F., Seroqui M., Silva R., Unterkircher B., Vicente C., Vieira N., Xavier J.P., Zucchetti C., Angelova I., Dimitrov G., Genova D., Gospodinov K., Goudev A., Grigorova V., Hristova K., Makedonska J.J., Katova T., Kostov K., Lazov P., Manov E., Manukov I., Manukov D., Milanova M., Kabakchieva V.M., Petrov D., Petrusheva T., Pramatarova I., Raev D., Runev N., Sirakova-Taseva A., Tisheva-Gospodinova S., Todorova A., Tzekova M., Yakovova S., Yanev T., Abulencia K., Arora S., Baker A., Bata I.R., Beaudry M., Belle Isle J., Bilodeau N., Boivin M.C., Bolduc H., Bourgeois S., Brons S., Cantor W., Chaussé I., Chhabra A., Chouinard G., Cleveland T., Dattani D., Deslongchamps F., Diodati J., Drouin K., Duchesne L., Fontaine S., D'Amours D.G., Gervais B., Gosselin G., Graham J., Grover A., Gupta A., Haldane H., Hartleib M., Hickey L., Huynh T., Johnston J., Julien V.E., Lachance P., Lake J., Lamontagne C., Lauzon C., Lepage S., Maheux K., Manyari D., Martin E., McPherson C., Mehta S., Michaud N., Kouz S.M., Murphy G., OKeefe D., Otis R., Ouimet F., Pandey S., Peck C., Perkins L., Richert L., Robbins K., Robinson S., Cabau J.R., Ross B., Roy C., Roy M., Roy A., Rupka D., Affaki G.S., Saunders K., Savard D., Soucy D., St Amour E., Thiessen S., Vertes G., Vezina M., Vincelli G., Weisnagel S.J., Zadra R., Chen J., Chen Y., Dong X., Feng Y., Feng Z., Fu G., Han B., Hao Y., He Y., He Z., Hong T., Jia Z., Jiang T., Jiang J., Jiang X., Ke Y., Li Y., Li Z., Li W., Li X., Liu P., Liu Y., Liu B., Liu S., Liu L., Lu Z., Lv Y., Ma C., Ma G., Peng L., Qing L., Ren L., Sang X., Song M., Sun Z., Wang J., Wang Y., Wei J., Wu W., Wu J., Xu H., Yan J., Yang P., Yang K., Yao Z., Yaoqing H., Yuan Z., Zhai Z., Zhang J., Zhang Y., Zhao R., Zhou H., Accini Mendoza JL., Aparicio C.V., Castillo T., Chaverra I., Conrado Y., Coronel J., Cotes C., Cuentas I., Cuervo A., Dussan M.A., Echeverria L., Hernandez E., Ibarra J., Isaza D., Jimenez D., Lopez P., Manzur F., Mejia I., Mendoza Y., Molina D.I., Patino J.M., Rodriguez D., Rodriguez L.M., Rodriguez S.M., Sanchez Vallejo G., Luz Serrano H., Sotomayor A., Urina M., Vesga B., Yupanqui H., Akrap B., Busic N., Ciglenecki N., Cmrecnjak J., Fucak E., Gabor M., Jeric M., Jutrisa N., Kordic K., Planinc I., Popovic Z., Radeljic V., Sesto I., Sutalo K., Tusek S., Belohlavek J., Budkova J., Busak L., Capova L., Cech V., Cermak O., Coufalova Z., Cyprian R., Dedek V., Dedkova S., Ferkl R., Hanak P., Hanustiakova A., Homza M., Horackova K., Houra M., Iveta H., Kaiserova L., Kala P., Karel I., Kellnerova I., Koleckar P., Kreckova M., Krupicka J., Lorenc Z., Machova V., Malik J., Masarikova L., Matyasek I., Mikus M., Mikusova T., Ondrasik J., Otava M., Palubova L., Pavlickova L., Peterka M., Petrova I., Pokorna B., Povolny P., Radvan M., Reznakova S., Rickova Z., Roszkowska P., Rotreklova M., Samkova D., Skalicka H., Slechticka A., Sternthal P., Telekes P., Tesak M., Vesely P., Vesely J., Vins P., Vitovec M., Vodnansky P., Zidova M., Keba E., Laane E., Pool T., Randvee L., Ratnik E., Reimand M., Reinmets S., Rivis L., Siemann M., Stern M., Toom M., Vahula V., Apel T., Axthelm C., Ayasse D., Ayasse M., Baar M., Baeumer A., Bagi E.S., Becker B., Binder A., Blankenberg S., Braun P., Johansen B.B., Contzen C., Delfonso F., Denecke C., Dengler T., Donaubauer T., Eichinger G., Englmann E., Erhard M., Faghih M., Foerster A., Frankenstein L., Fuchs R., Furch G., Gaeb-Strasas B., Germann H., Giese C., Goette A., Gravenhorst-Muenter U., Haege R., Haenel T., Hagemann D., Hagenow A., Hanefeld M., Heider J., Heisters J., Hennig D., Hielscher S., Himpel-Boenninghoff A., Holscher A., Hornig M., Jeserich M., Kaczmarek N., Kanitz S., Kara Y.D., Khariouzov A., Kiefer R., Kiroglu K., Klamm M., Klein C., Korth-Wiemann B., Krapivsky A., Kuenzler J., Kuntzsch A., Landers B., Lappo M., Laube S., Leggewie S., Lehmann D., Lepp H., Lierse T., Lindner C., Luecke-Uzar M., Luedemann J., Marschke T., Maruzzo S., Mauersberger K., Maus O., Meinrich M., Meissner A., Moehring B., Muehlhaus J., Mueller S., Muenter K.C., Muenzel T., Naumann R., Nebel J., Neumann J., Nuding S., Overhoff U., Papke B., Pencz I., Peter Y., Peukert A.M., Radde I., Rau T., Regner S., Reichenbach D., Reimer D., Rinke A., Roettges R., Romanski A., Rummel R., Samer H., Sanuri M., Sarnighausen H.E., Schäfer B., Scheibner T., Schermaul K.H., Schindler A., Schlundt C., Schmidt E., Schmidt K., Schnabel A., Schoen N., Schorn K., Schroeder T., Schulenburg D., Schulz M., Schulze U., Schulze J., Schumacher M., Schwerin G., Schwerin M., Stadelmeier S., Stahl H.D., Stahl A., Stockhausen J., Stockhausen G., Stoessel J., Stolze K., Stratmann M., Szymanowski N., Teschner A.B., Teske A., Uecker C., Veit S., Voeller H., Walter I., Walter J., Walther I., Weber H.G., Weimer J., Wichterich K., Wiebusch A., Willmerdinger M., Willner C., Winkelmann B., Winkler J., Wistuba T., Woehrle J., Wohnlich T., Wolf S., Woyczak D., Wrage P., Zirlik A., Anadiotis A., Chachalis 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Raghu C., Chauhan D., Chauhan H., Chavada J., Chaware G., Chella S., Chintala P., Dash D., Desai D., Devasia T., Dhanak R., Dobariya H., Dudhatra N., Duhan S., Fulwani M., Ghondale N., Ghosh S., Gohel P., Govindaraj D., Goyal B., Goyal S., Gundala A.K., Gupta M., Hardas S., Iby M., Jagtap P., Jain A., Joshi U., Karpuram M., Kaur H., Khan A., Khan R., Kodem D.R., Koeitti P., Kulkarni L., Kullal P., Kumar K.S., Kumbla M., Latheef K., Lohkare M., Santosh M.J., Makhe B., Mandati M., Mehta A., Minocha G., Mittal A., Modi R., Mohan K., Oomman A., Pai R., Pai V., Palaniswami N., Pansheriya A., Parekh N., Patel J., Patel R., Patole T., Praveen M., Radhakrishnan V., Rajan B A., Rajasekhar D., Rao M., Rao M.B., Rao N.M., Rathnavel S., Rathore A., Rathore SRS., Rawat S., Reddy N.C., Sarma R., Sathe S., Shah J., Shaikh P., Sharma K., Sharma S., Sharma T., Shetty P., Sidhu G., Singh V., Sohi G.S., Srinath V.S., Raju S.S., Taran A., Thakkar B., Velusamy K., Vijan V., Vora V., Vuriya A.K., Agosta G.F., Antonicelli R., Ardissino D., Argiolas G., Baldin M.G., Benedetti G., Berti S., Bevilacqua M.T., Bolognesi M.G., Dessalvi C.C., Calabrese A., Campanale E.G., Candusso R., Caso P., Cosmi F., Crea F., Crocamo A., De Caterina R., De Rosa S., Destro M., Di Biase M., Dognini G.P., Eleuteri E., Fedele F., Ferrario M., Gabrielli D., Gamba C., Ganau A., Gravellone M., Iannopollo G., Indolfi C., Infusino F., Invitti C., Landolfi A., Lembo G., Liberato N.L., Mannucci E., Marino P., Mariottoni B., Marziali A., Mercuro G., Monti L., Mos L., Mureddu V., Musumeci M.B., Novo S., Panzarino C., Parente A., Perotti M., Filardi P.P., Petrillo C., Piatti P., Priori S., Racca V., Ragghianti B., Renda G., Righini V., Sarcone M., Senni M., Soro E., Tamburrini P., Vallone L., Villani G.Q., Volpe M., Ajioka M., Akai Y., Ashino K., Baden M., Doi M., Eki Y., Endo T., Fukuike C., Hagiwara Y., Hasegawa K., Higuchi Y., Higuchi T., Hioki M., Hirayama A., Hiroma J., Hosokawa S., Ichisawa M., Iijima T., Inada T., Inagaki M., Ito K., Kaigawa K., Kajihara S., Kamiya H., Kamiya J., Kaneno Y., Katahira K., Kataoka M., Kawai M., Kawasaki T., Kojima E., Komura Y., Kuramochi T., Kuruma T., Kyo E., Mani H., Miyamoto T., Morii I., Morinaga Y., Morisawa T., Nagai Y., Naka T., Nakamura Y., Nakamura S., Nakayoshi K., Nishibe A., Ogawa M., Okada Y., Okawa M., Sakamoto Y., Sakurada M., Sasaki S., Seki S., Shimomura H., Shinozaki T., Sugimoto N., Suzuki A., Taguchi S., Takahashi J., Takase S., Tanabe K., Tanaka A., Tani S., Tomioka J., Tsuboi H., Tsuji M., Tsujita K., Tsujiyama S., Umesu A., Yamada T., Yamaguchi E., Yamamoto H., Yamamoto T., Yamane M., Yanase T., Yasuoka S., Yasutake M., Yokoyama M., Yoshida M., Yoshimoto E., Yunoki C., Balode A., Dormidontova G., Flaksa I., Nagele-Luse I., Rancane G., Sime I., Bartuseviciene S., Cepinskiene L., Dobilas V., Grigaraviciene I., Marcinkeviciene J., Mazutavicius R., Miliuniene R., Motiejuniene R., Norkiene S., Norkute-Macijauske U., Rudys A., Slapikas R., Stonkute K., Strazdiene D., Tijuneliene E., Urbonas G., Vanagiene S., Viezelis M., Arenas Leon JL., Bayram E., Carrillo J., Davalos C., De Los Rios M., Delgadillo T., Hernández N., Leon S., Mendoza N., Muñoz W., Ramos G., Anneveldt A., Bakker H., Brouwer M., Bunschoten P., De Boer P., De Jong C., De Vos A., Den Hartog F., Doesborg L., Dommerholt R., Drost I., Ellenbroek D., Engelen W., Folkeringa R.J., Hamer BJB., Herrman J.P., Hoogslag PAM., Jansen M., Jerzewski A., Joosten C., Kalkman C., Kietselaer B., Kok M., Kooiman E., Kose V., Lardinois R., Lenderink T., Lok DJA., Lousberg A., Meijlis P., Mulder R., Singerling M., Smeele F., Stroes E., Swart H.P., Ten Holt W., Van Der Wal M., Van Der Zwaan C., Van Kempen W.W., Van Maarseveen M., Van Stein I., Viergever E.P., Visseren FLJ., Voors C., Nugteren SKZ., Ata B., Berulfsen A., Rønnevik T.D., Dickstein K., Furuseth B., Grundtvig M., Hansen H., Hofsoey K., Høivik H.O., Bøen R.H., Hurtig U., Pettersen K.I., Johansen E., Kleve R., Kolleroy C., Moen S., Nilsen V., Norin V., Otterstad J.E., Risberg K., Rønnevik P., Sirnes P.A., Skjelvan G., Strand S., Szacinski G., Vegsundvåg J., Alcalde J.M., Gomez Sanchez J., Rodriguez J., Rodriguez A., Zena N., Baszak J., Cymerman K., Czerski T., Fratczak M., Jaguszewska G., Kawka-Urbanek T., Koba M., Kopaczewski J., Kopczyńska M., Laniec M., Lysek R., Sciborski R., Szpajer M., Torun A., Wujkowski M., Zielinski M., Ahn Y., Baek C., Bang S.A., Chang K., Choi A.J., Han S., Hyun K., Kim M., Kim K.S., Kim B., Lee S.H., Lee J., Lee H.N., Lee J.H., Moon K., Park B., Park C., Tahk S., Yim K.H., Yim S., Tase T., Andor M., Aron G., Badea C., Casoinic F., Clocotan M., Coman S., Emil B., Imre B.S., Istratoaie O., Liviu C., Maximov D., Militaru C., Minescu B., Istvan K.P., Parepa I., Petrescu L., Podoleanu C., Pop C.F., Popa V., Popescu E., Radoi M., Sarbu I., Socoteanu E., Socoteanu G., Sorodoc L., Spiridon M., Stanciulescu G., Stefanescu M., Tanaseanu C., Tudoran M., Zdrenghea D., Agafina A., Akatova E., Avdonina N., Balukova E., Barbarash O.L., Bartosh L., Boyarkin M., Bulashova O., Burova N., Churina S., Demidova M., Dorogova I., Dovgalevskiy Y., Dovgolis S., Dudarev M., Fitilev S., Gapon L., Gazizianova V., Gordeev I., Ivanov I., Izmozherova N., Kazanskay E., Khirmanov V., Khromtsova O., Konradi A., Kosmacheva E., Kozlova S., Kulibaba E., Kuzin A., Libov I., Lipchenko A., Lozhkina N., Malchikova S., Morozov E., Myslyaeva L., Onuchina E., Palatkina T., Panov A., Parmon E., Petelina T., Repin A., Reznik I., Sazonova E., Sergienko T., Shaposhnik I., Shapovalova Y., Shustov S., Shvarts Y., Skopets I., Skuratova M., Smolenskaya O., Solovev O., Trofimov V., Vasiliev M., Vezikova N., Vozzhaev A., Yakushin S., Zadionchenko V., Apostolovic S., Adjic N.C., Ilic I., Ilic S., Nikolic L., Pupic L., Stokuca-Korac N., Antalik L., Bugan V., Csala L., Dokupilova A., Dzupina A., Forgon T., Fulop P., Gonsorcik J., Gyorgyova E., Holoubek D., Horvat P., Kamensky G., Kolikova V., Krupciakova B., Lenner E., Lennerova J., Lukac J., Majercak I., Mancikova I., Micko K., Nociar J., Pales J., Palka J.Jr., Poliacik P., Ruffini L., Sabo L., Skubova K., Slanina M., Smik R., Srdos V., Stitova M., Stofkova D., Strbova J., Such S., Toth P., Urgeova L., Vinanska D., Zareczky P., Flezar M., Kovacic D., Marcun R., Zagozen P., Bolsmann C., Conradie C., Dawood S.Y., Decsi K.L., Ebrahim I., Henley L., Horak A., Kapp I., Komati S., Lock E., Maboyi S., Makotoko E., Manga P., Page A., Ramdas S., Ranjith N., Roos J., Talliard C., Ajax K., Al-Khalili F., Assarsson E., Bergholtz T., Blom K.B., Boman K., Boström P.A., Curiac D., Jensen E.D., Dahlen G., Davidsson K., Duckert A., Hansson A., Härstedt N., Henriksson A., Olsson G.H., Johansson K., Jonsson J.E., Knutsson A., Lindholm C.J., Lönnberg I., Lundqvist M., Mellberg L., Moodh J., Mooe T., Olofsson M., Risenfors M., Rönndahl M., Sundelin R., Suorra I., Torgersruud M., Torstensson I., Chen C.P., Chen Z.C., Chen M.H., Cheng S.M., Cheng J.J., Fang C.Y., Ho C.J., Hsieh I.C., Huang P.H., Huang A., Kuo J.Y., Lai W.T., Lee S.C., Lin T., Liu H.M., Tsai M.C., Tsao H.M., Tzong L., Ueng K.C., Wang Y.L., Wang H.C., Wang C.P., Yang C.C., Abaci F., Birdane A., Yilmaz M.B., Asim Oktay AO., Kan G., Koldas N., Ozcan I.T., Sahin M., Sahin T., Saka B., Tekten T., Ucar N., Uresin S., Yigit Z., Arif I., Bakhai A., Baksi A., Blagdon M., Brickman T., Brown N., Burton M., Burton J., Chaggar S., Chung A., Collier D., Covell W., Crawford G., Davies N., Davies M., Dayer M., Doughty A., Duff J., Dwenger E., Fisher J., Fitzpatrick L., Garner K., Glover J., Haughton G., Ilsley M., Ivan P., Voyzey E.J., Keenan S., Kelt T., Knight J., Kondagunta V., Lang C., Lee K., Lim L., Macdonald J., Mathew A., Mckenzie A., Mckibbin A., Michalska A., Pagett K., Pogson A., Price R., Price D., Procter K., Pye M., Redfearn H., Rewbury J., Ryding A., Sattar N., Sharp A., Shaw P., Simpson H., Smith W., Squire I., Storey R., Teenan M., Thomas H., Townend J., Trevelyan J., Wakeling J., Walukiewicz P., Wilkinson S., Zaman A., Acevedo L., Benton J., Abbate A., Aboufakher R., Acampora M., Acampora D., Aceto L., Acevedo B., Acheatel R., Adams M., Adams A., Ahmad I., Ahmed S.H., Aish B., Akyea-Djamson A., Al Joundi T., Alcide P., Alfieri A., Alfonso T., Alfrey A., Allen J., Alllison D.C., Almaliky T., Amos A., Angiolillo D., Antolick A., Ara M., Aragorn L., Arevalo S., Armas E., Arthur A., Asafu-Adjaye N., Ashcom T., Ashford M., Aslam A., Ather N., Atieh M., Aull L., Ayala M., Azizad M., Backer T., Baehl S., Bailey S., Bair S., Baker C., Ballmajo M., Pieretti H.B., Baquero A., Barnett S., Baron S., Bartkowiak A., Bashir K., Beall K., Beauregard L.A., Sarah S., Beckett L., Belejchak P., Bendelow T., Bender D., Benjamin S., Berdoff R., Berger V., Bergeron P., Berk M., Bernstein M., Binns Y., Bitzer V., Blahey M., Bloch S., Bluemel J., Boffetti P., Boley K., Bonner J., Boudreaux R., Boulanger K., Bradley A., Bramlet D., Bredlau C., Briggs S., Brousalis L., Brown S., Brown C., Buchannan C., Burke W., Burley T., Burton C., Burtt D., Byars W., Caballero-Valiente B., Carr K., Halliwell T.C., Castillo J., Cei L., Cerda L., Chambers J., Chamblee T., Chattin W., Chee L., Chen Y.C., Cherlin R., Cheung D., Chiodi L., Christensen L., Christenson S., Cislowski D., Clavier-Firmin C., Colfer H., Colvin T., Cosgrove N., Covert C., Cox B., Cox R., Craig W., Crandall L., Crepps K., Cromer M., Cruz H., Cruz M., Cucher F., Damron M., Dave K., Dave B., Davis M., Davis B., Dawkins-Hughes S., Dean J., Debnam S., Defosse C., Dehning M., Dela Llana A., Dellorso M., Denham D., Desalle D., Dettmer M., Dhawan M., Diago M., Dicken T., Diederich C., Diederich M., Diehl R., Digangi D., Diller P., Dimattia M., Dodds G., Doggett J., Donahue K., Doughty L., Dragutksy B., Dreese M., Dunhurst F., Dunn D., Dutka C., Earl J., Eaton C., Eaves W., Ebeling K., Eder F., Edgerton L., Edillo C., Edwards J., Edwards T., Einhorn D., El Hafi S., Ellis M., Erickson B., Ervin W., Eskridge L., Fail P., Falcon D., Fang C., Fattal P., Fawson A., Felix L., Ferdinand K., Fien E., Fintel D., Firek C., Fitz-Patrick D., Flores E., Flores H., Floro T., Forker A., Foster M., Foucauld J., Lehman K.F., Fox B., Francoeur L., Frandsen B., Frivold G., Fruchter G., Fullerton D., Gabriel J., Gacioch G., Garas S., Garcia N., Garcia Rinaldi R., Garcia-Fragoso V., Garcia-Portela M., Gelb R., George F., Ghali J., Gilbert J., Gilley J., Glancy R., Goff R., Goldberg N., Gonzales D., Gonzales V., Gonzalez E., Gorges R., Gould R., Grabeau R., Grable M., Graham J.A., Graif J., Green E., Greener R., Greenway F., Grieshaber V., Griffin S., Gros C., Gudipati RVC., Guillinta P., Gupta V., Gutmann J., Gwyn M., El Hachem M., Hage F., Hageman T., Haidar A., Hakas J., Haldis T., Hall L., Hall C., Hall S., Halpern S., Hamud-Socoro A., Hardee L., Harrell W., Harrington A., Hartwell J., Hasan F., Hattler B., Haught H., Haynes E., Haywood A., Heaney L., Hecht J., Hernandez I., Herzog W., Hess E., Hill H., Hilton T., Hinderaker P., Hodnett P., Hoffman M., Hogan C., Holmes Z., Rees D.H., Hotchkiss D., Huang P., Humbert J., Hutchens E., Iachini K., Ibarra M., Igbokidi O., Ilahi T., Imbrognio M., Ipp E., Iteld B., Jacques G., Jafri A., Jafry B., Jardula M., Jefferson D., Jenkins R., Johnson E., Johnson J., Jones S., Kawahara M., Kelehan S., Kelly R., Kendall T., Kereiakes D., Khan M., Khan S., Kick J., Kimmel M., King T., King A., Kirkland S., Kissel S., Kitchens D., Klein P., Klugherz B., Korban E., Koren M., Korte M., Kostis J., Kotek L., Kozak M., Kreutter F., Kusnick B., Labovitz R., Lail J., Lamance J., Lamas G., Lambert J., Lambert C., Landzberg J., Langdon J., Lavoie W., Ledger G., Lee T., Lehman R., Leimbach W., Lennard M., Lepor N., Lester F., Levin P., Levinson L., Lewis D., Lillo J., Link L., Long C., Longaker R., Lorch G., Lucksinger G., Lynd S., Rhudy J.M., Madder R., Magness K., Maheshwari A., Alan A., Malek M., Maletz L., Malhotra V., Malhotra S., Mandviwala M., Mani C.K., Manuel J., Marchelletta N., Marshall L., Marsters M., Martin L., Martinez E., Mavromatis K., Maynard R., Mays M., Mays B., Mbulaiteye A., Mcalister R., Mccoy C., Mccrary D.Jr., Mccullough-O'Brien H., Mcdonald M., Mcgill J., Mcgrew F., Mckenzie C., Mclaurin B., Mclellan B.A., Mcneil D., Mcneill R., Mehrle A., Melbie K., Melliza T., Messina T., Meyer R., Michel K., Mikdadi G., Miller C., Miller R., Miller A., Miller G., Miller W., Mitchell J., Moats DJR., Mody F., Moffat J., Molk B., Molter D., Monroe T., Montero H., Montgomery R., Mookherjee D., Moran J., Moriarty P., Morrison J., Morton D., Moshayedi P., Mosley J., Moustafa M., Munshi K., Murray A., Mustafa J., Nadar V., Naidu R., Nalley J., Navy S., Neil L., Neutel J.M., Niblack P., Nicely V., Nicolai M., Nijmeh G., Nikas A., Nikyar A., Nixon S., Norman L., Noto G., Nour K., Nugent A., Ocman B., Odegard A., Olsen S., Ortiz-Carrasquillo R., Ossino N., Paez H., Palchick B., Paliwal Y., Pannell R., Parfait V., Partridge J., Patel B., Patel M., Patel S., Paysor C., Pena A., Pereira S., Perez M., Perez A., Perkins H., Perry B., Peters P., Phillippi C., Phillips A., Piacente R., Pintado M., Pish R., Pitt W., Poling T., Pomposini D., Poock J., Potts J., Poudrier R., Prior J., Pritchard C., Purighalla R., Quddusi K., Quinones J., Quinton D., Radin M., Radojcsics B., Rajput B., Rama B., Ramos M., Rauch R., Raynes K., Reber A.M., Reddy J., Reeves M., Reilly K., Renaud K., Resnick H., Reyes R., Richardson M., Riethof M., Riser J., Rodero M., Rodriguez Araya E., Roper L., Rozeman P., Ruder D., Runquist L., Sack G., Saint-Jacques H., Salfity M., Sall N., Sam K., Samal A., Sanchez D., Santiago J.Jr., Savignano C., Saylor R., Scheffel M., Schifferdecker B., Schindler E., Schneider P., Schneider R., Schnitzler R., Schrager B., Schwartz A., Scott R., Seals A., Shah A.V., Shah A., Shatsky K., Shayani S., Shealy N., Sheets L., Shelley J., Shepard P., Shetty S., Silver K., Simon M., Singh K., Singh N., Sizemore B.C., Skatrud L., Slayton C., Slimak V., Sloane G., Smallwood B., Smith P., Smith M., Smith T., Smith G., Smith B., Smith J., Soca Y., Sofley C., Sopko K., Sosa-Padilla M., Sotolongo R., Sprinkle B., Srivastava S., Starzec M., Steinhoff J., Stelly L., Stinson J., Stoddard M., Stoltz S., Stone B., Stover T., Strain J., Strugatsky S., Stys T., Suleman A., Sullivan P., Tamez W., Tandon N., Teltser M., Terry P.S., Terry K., Tessmar C., Thekkoott D., Thomas D., Thomas D.M., Thompson E., Thompson J., Thornton A., Tjaden T., Tobias C., Topper J., Tran A., Treasure C., Trenkamp P., Trevino M., Tsou L., Tuholske C., Uy W., Vahtel M., Vaid B., Valenzuela M., Vance A., Vandam J., Vanhecke T., Vanness WC III., Vargas R., Vaz S., Vazquez Tanus J., Veerina K., Vega J., Vento A., Vijay N., Voelker F., Vogt E., Vold D., Vora K., Wade R.D., Wadell C., Waksman R., Walker K., Wallace K., Warren M., Washam M., Watson B., Webel R., Wells T., West M., Whitaker J., White J., White C., White A., Wilhoit G., Wilkins M., Willingham K., Wilson S., Wilson V., Wise J., Woodall S., Woods A., Wright J., Xu Z.J., Yarows S., Young A., Younis L., Zarate J., Zebrack J., Zhang W., Zieve F., and Zineldine A.
- Abstract
BACKGROUND: Experimental and clinical data suggest that reducing inflammation without affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory hypothesis of atherothrombosis has remained unproved. METHODS: We conducted a randomized, double-blind trial of canakinumab, a therapeutic monoclonal antibody targeting interleukin-1β, involving 10,061 patients with previous myocardial infarction and a high-sensitivity C-reactive protein level of 2 mg or more per liter. The trial compared three doses of canakinumab (50 mg, 150 mg, and 300 mg, administered subcutaneously every 3 months) with placebo. The primary efficacy end point was nonfatal myocardial infarction, nonfatal stroke, or cardiovascular death. RESULTS: At 48 months, the median reduction from baseline in the high-sensitivity C-reactive protein level was 26 percentage points greater in the group that received the 50-mg dose of canakinumab, 37 percentage points greater in the 150-mg group, and 41 percentage points greater in the 300-mg group than in the placebo group. Canakinumab did not reduce lipid levels from baseline. At a median follow-up of 3.7 years, the incidence rate for the primary end point was 4.50 events per 100 person-years in the placebo group, 4.11 events per 100 person-years in the 50-mg group, 3.86 events per 100 person-years in the 150-mg group, and 3.90 events per 100 person-years in the 300-mg group. The hazard ratios as compared with placebo were as follows: in the 50-mg group, 0.93 (95% confidence interval [CI], 0.80 to 1.07; P=0.30); in the 150-mg group, 0.85 (95% CI, 0.74 to 0.98; P=0.021); and in the 300-mg group, 0.86 (95% CI, 0.75 to 0.99; P=0.031). The 150-mg dose, but not the other doses, met the prespecified multiplicity-adjusted threshold for statistical significance for the primary end point and the secondary end point that additionally included hospitalization for unstable angina that led to urgent revascularization (hazard ratio vs. placebo, 0.83
46. Genetic Evidence for Cytochrome bQiSite Inhibition by 4(1H)-Quinolone-3-Diarylethers and Antimycin in Toxoplasma gondii
- Author
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Alday, P. Holland, Bruzual, Igor, Nilsen, Aaron, Pou, Sovitj, Winter, Rolf, Ben Mamoun, Choukri, Riscoe, Michael K., and Doggett, J. Stone
- Abstract
ABSTRACTToxoplasma gondiiis an apicomplexan parasite that causes fatal and debilitating brain and eye disease. Endochinlike quinolones (ELQs) are preclinical compounds that are efficacious against apicomplexan-caused diseases, including toxoplasmosis, malaria, and babesiosis. Of the ELQs, ELQ-316 has demonstrated the greatest efficacy against acute and chronic experimental toxoplasmosis. Although genetic analyses in other organisms have highlighted the importance of the cytochrome bc1complex Qisite for ELQ sensitivity, the mechanism of action of ELQs against T. gondiiand the specific mechanism of ELQ-316 remain unknown. Here, we describe the selection and genetic characterization of T. gondiiclones resistant to ELQ-316. A T. gondiistrain selected under ELQ-316 drug pressure was found to possess a Thr222-Pro amino acid substitution that confers 49-fold resistance to ELQ-316 and 19-fold resistance to antimycin, a well-characterized Qisite inhibitor. These findings provide further evidence for ELQ Qisite inhibition in T. gondiiand greater insight into the interactions of Qisite inhibitors with the apicomplexan cytochrome bc1complex.
- Published
- 2016
- Full Text
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47. The Science Performance of JWST as Characterized in Commissioning
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Jane Rigby, Marshall Perrin, Michael McElwain, Randy Kimble, Scott Friedman, Matt Lallo, René Doyon, Lee Feinberg, Pierre Ferruit, Alistair Glasse, Marcia Rieke, George Rieke, Gillian Wright, Chris Willott, Knicole Colon, Stefanie Milam, Susan Neff, Christopher Stark, Jeff Valenti, Jim Abell, Faith Abney, Yasin Abul-Huda, D. Scott Acton, Evan Adams, David Adler, Jonathan Aguilar, Nasif Ahmed, Loïc Albert, Stacey Alberts, David Aldridge, Marsha Allen, Martin Altenburg, Javier Álvarez-Márquez, Catarina Alves de Oliveira, Greg Andersen, Harry Anderson, Sara Anderson, Ioannis Argyriou, Amber Armstrong, Santiago Arribas, Etienne Artigau, Amanda Arvai, Charles Atkinson, Gregory Bacon, Thomas Bair, Kimberly Banks, Jaclyn Barrientes, Bruce Barringer, Peter Bartosik, William Bast, Pierre Baudoz, Thomas Beatty, Katie Bechtold, Tracy Beck, Eddie Bergeron, Matthew Bergkoetter, Rachana Bhatawdekar, Stephan Birkmann, Ronald Blazek, Claire Blome, Anthony Boccaletti, Torsten Böker, John Boia, Nina Bonaventura, Nicholas Bond, Kari Bosley, Ray Boucarut, Matthew Bourque, Jeroen Bouwman, Gary Bower, Charles Bowers, Martha Boyer, Larry Bradley, Greg Brady, Hannah Braun, David Breda, Pamela Bresnahan, Stacey Bright, Christopher Britt, Asa Bromenschenkel, Brian Brooks, Keira Brooks, Bob Brown, Matthew Brown, Patricia Brown, Andy Bunker, Matthew Burger, Howard Bushouse, Steven Cale, Alex Cameron, Peter Cameron, Alicia Canipe, James Caplinger, Francis Caputo, Mihai Cara, Larkin Carey, Stefano Carniani, Maria Carrasquilla, Margaret Carruthers, Michael Case, Riggs Catherine, Don Chance, George Chapman, Stéphane Charlot, Brian Charlow, Pierre Chayer, Bin Chen, Brian Cherinka, Sarah Chichester, Zack Chilton, Taylor Chonis, Mark Clampin, Charles Clark, Kerry Clark, Dan Coe, Benee Coleman, Brian Comber, Tom Comeau, Dennis Connolly, James Cooper, Rachel Cooper, Eric Coppock, Matteo Correnti, Christophe Cossou, Alain Coulais, Laura Coyle, Misty Cracraft, Mirko Curti, Steven Cuturic, Katherine Davis, Michael Davis, Bruce Dean, Amy DeLisa, Wim deMeester, Nadia Dencheva, Nadezhda Dencheva, Joseph DePasquale, Jeremy Deschenes, Örs Hunor Detre, Rosa Diaz, Dan Dicken, Audrey DiFelice, Matthew Dillman, William Dixon, Jesse Doggett, Tom Donaldson, Rob Douglas, Kimberly DuPrie, Jean Dupuis, John Durning, Nilufar Easmin, Weston Eck, Chinwe Edeani, Eiichi Egami, Ralf Ehrenwinkler, Jonathan Eisenhamer, Michael Eisenhower, Michelle Elie, James Elliott, Kyle Elliott, Tracy Ellis, Michael Engesser, Nestor Espinoza, Odessa Etienne, Mireya Etxaluze, Patrick Falini, Matthew Feeney, Malcolm Ferry, Joseph Filippazzo, Brian Fincham, Mees Fix, Nicolas Flagey, Michael Florian, Jim Flynn, Erin Fontanella, Terrance Ford, Peter Forshay, Ori Fox, David Franz, Henry Fu, Alexander Fullerton, Sergey Galkin, Anthony Galyer, Macarena García Marín, Jonathan P. Gardner, Lisa Gardner, Dennis Garland, Bruce Garrett, Danny Gasman, Andras Gaspar, Daniel Gaudreau, Peter Gauthier, Vincent Geers, Paul Geithner, Mario Gennaro, Giovanna Giardino, Julien Girard, Mark Giuliano, Kirk Glassmire, Adrian Glauser, Stuart Glazer, John Godfrey, David Golimowski, David Gollnitz, Fan Gong, Shireen Gonzaga, Michael Gordon, Karl Gordon, Paul Goudfrooij, Thomas Greene, Matthew Greenhouse, Stefano Grimaldi, Andrew Groebner, Timothy Grundy, Pierre Guillard, Irvin Gutman, Kong Q. Ha, Peter Haderlein, Andria Hagedorn, Kevin Hainline, Craig Haley, Maryam Hami, Forrest Hamilton, Heidi Hammel, Carl Hansen, Tom Harkins, Michael Harr, Jessica Hart, Quyen Hart, George Hartig, Ryan Hashimoto, Sujee Haskins, William Hathaway, Keith Havey, Brian Hayden, Karen Hecht, Chris Heller-Boyer, Caroline Henriques, Alaina Henry, Karl Hermann, Scarlin Hernandez, Brigette Hesman, Brian Hicks, Bryan Hilbert, Dean Hines, Melissa Hoffman, Sherie Holfeltz, Bryan J. Holler, Jennifer Hoppa, Kyle Hott, Joseph M. Howard, Rick Howard, Alexander Hunter, David Hunter, Brendan Hurst, Bernd Husemann, Leah Hustak, Luminita Ilinca Ignat, Garth Illingworth, Sandra Irish, Wallace Jackson, Amir Jahromi, Peter Jakobsen, LeAndrea James, Bryan James, William Januszewski, Ann Jenkins, Hussein Jirdeh, Phillip Johnson, Timothy Johnson, Vicki Jones, Ron Jones, Danny Jones, Olivia Jones, Ian Jordan, Margaret Jordan, Sarah Jurczyk, Alden Jurling, Catherine Kaleida, Phillip Kalmanson, Jens Kammerer, Huijo Kang, Shaw-Hong Kao, Diane Karakla, Patrick Kavanagh, Doug Kelly, Sarah Kendrew, Herbert Kennedy, Deborah Kenny, Ritva Keski-kuha, Charles Keyes, Richard Kidwell, Wayne Kinzel, Jeff Kirk, Mark Kirkpatrick, Danielle Kirshenblat, Pamela Klaassen, Bryan Knapp, J. 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Reichard, Carl Reis, Michael E. Ressler, Armin Rest, Paul Reynolds, Timothy Rhue, Karen Richon, Emily Rickman, Michael Ridgaway, Christine Ritchie, Hans-Walter Rix, Massimo Robberto, Gregory Robinson, Michael Robinson, Orion Robinson, Frank Rock, David Rodriguez, Bruno Rodriguez Del Pino, Thomas Roellig, Scott Rohrbach, Anthony Roman, Fred Romelfanger, Perry Rose, Anthony Roteliuk, Marc Roth, Braden Rothwell, Neil Rowlands, Arpita Roy, Pierre Royer, Patricia Royle, Chunlei Rui, Peter Rumler, Joel Runnels, Melissa Russ, Zafar Rustamkulov, Grant Ryden, Holly Ryer, Modhumita Sabata, Derek Sabatke, Elena Sabbi, Bridget Samuelson, Benjamin Sapp, Bradley Sappington, B. Sargent, Arne Sauer, Silvia Scheithauer, Everett Schlawin, Joseph Schlitz, Tyler Schmitz, Analyn Schneider, Jürgen Schreiber, Vonessa Schulze, Ryan Schwab, John Scott, Kenneth Sembach, Clare Shanahan, Bryan Shaughnessy, Richard Shaw, Nanci Shawger, Christopher Shay, Evan Sheehan, Sharon Shen, Allan Sherman, Bernard Shiao, Hsin-Yi Shih, Irene Shivaei, Matthew Sienkiewicz, David Sing, Marco Sirianni, Anand Sivaramakrishnan, Joy Skipper, G. C. Sloan, Christine Slocum, Steven Slowinski, Erin Smith, Eric Smith, Denise Smith, Corbett Smith, Gregory Snyder, Warren Soh, Sangmo Tony Sohn, Christian Soto, Richard Spencer, Scott Stallcup, John Stansberry, Carl Starr, Elysia Starr, Alphonso Stewart, Massimo Stiavelli, Amber Straughn, David Strickland, Jeff Stys, Francis Summers, Fengwu Sun, Ben Sunnquist, Daryl Swade, Michael Swam, Robert Swaters, Robby Swoish, Joanna M. 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A., Reis, C., Ressler, M. E., Rest, A., Reynolds, P., Rhue, T., Richon, K., Rickman, E., Ridgaway, M., Ritchie, C., Rix, H. -W., Robberto, M., Robinson, G., Robinson, M., Robinson, O., Rock, F., Rodriguez, D., Rodriguez Del Pino, B., Roellig, T., Rohrbach, S., Roman, A., Romelfanger, F., Rose, P., Roteliuk, A., Roth, M., Rothwell, B., Rowlands, N., Roy, A., Royer, P., Royle, P., Rui, C., Rumler, P., Runnels, J., Russ, M., Rustamkulov, Z., Ryden, G., Ryer, H., Sabata, M., Sabatke, D., Sabbi, E., Samuelson, B., Sapp, B., Sappington, B., Sargent, B., Sauer, A., Scheithauer, S., Schlawin, E., Schlitz, J., Schmitz, T., Schneider, A., Schreiber, J., Schulze, V., Schwab, R., Scott, J., Sembach, K., Shanahan, C., Shaughnessy, B., Shaw, R., Shawger, N., Shay, C., Sheehan, E., Shen, S., Sherman, A., Shiao, B., Shih, H. -Y., Shivaei, I., Sienkiewicz, M., Sing, D., Sirianni, M., Sivaramakrishnan, A., Skipper, J., Sloan, G. C., Slocum, C., Slowinski, S., Smith, E., Smith, D., Smith, C., Snyder, G., Soh, W., Tony Sohn, S., Soto, C., Spencer, R., Stallcup, S., Stansberry, J., Starr, C., Starr, E., Stewart, A., Stiavelli, M., Straughn, A., Strickland, D., Stys, J., Summers, F., Sun, F., Sunnquist, B., Swade, D., Swam, M., Swaters, R., Swoish, R., Taylor, J. 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- Subjects
Science & Technology ,Observatories ,Infrared astronomy ,Astronomical instrumentation ,INFRARED SPECTROGRAPH NIRSPEC ,FOS: Physical sciences ,Astronomy and Astrophysics ,Astronomy & Astrophysics ,Settore FIS/05 - Astronomia e Astrofisica ,Space and Planetary Science ,Physical Sciences ,Astrophysics - Instrumentation and Methods for Astrophysics ,[PHYS.ASTR] Physics [physics]/Astrophysics [astro-ph] ,Instrumentation and Methods for Astrophysics (astro-ph.IM) - Abstract
This paper characterizes the actual science performance of the James Webb Space Telescope (JWST), as determined from the six month commissioning period. We summarize the performance of the spacecraft, telescope, science instruments, and ground system, with an emphasis on differences from pre-launch expectations. Commissioning has made clear that JWST is fully capable of achieving the discoveries for which it was built. Moreover, almost across the board, the science performance of JWST is better than expected; in most cases, JWST will go deeper faster than expected. The telescope and instrument suite have demonstrated the sensitivity, stability, image quality, and spectral range that are necessary to transform our understanding of the cosmos through observations spanning from near-earth asteroids to the most distant galaxies., Comment: 5th version as accepted to PASP; 31 pages, 18 figures; https://iopscience.iop.org/article/10.1088/1538-3873/acb293
- Published
- 2022
- Full Text
- View/download PDF
48. MFTF-. cap alpha. +T: an upgrade to the MFTF-B
- Author
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Doggett, J
- Published
- 1983
49. Tandem mirrors for neutron production
- Author
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Doggett, J
- Published
- 1983
50. Mechanical-engineering aspects of mirror-fusion technology
- Author
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Doggett, J
- Published
- 1982
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