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Introduction: The use of interrupted nitrous oxide-oxygen (N2O-O2) sedation technique will minimize chronic exposure to ambient nitrous oxide and its health hazard to the dental team and patient. The aim is to evaluate and compare the effectiveness of interrupted and continuous administration of N2O-O2 sedation in managing anxious children 4 to 8 years undergoing primary molar rehabilitation. The objective is to assess and compare the physical, physiological, and psychological changes in the behavior of anxious children during interrupted and continuous N2O-O2 sedation techniques. Methodology Including Study Design: It is a double-blinded randomized controlled trial. Forty-two healthy children, 4-8 years of age, with a need for mandibular molars rehabilitation, were included in the study. The 42 children were randomly divided into groups: (1) interrupted N2O-O2 sedation technique and (2) continuous nitrous oxide-oxygen N2O-O2 sedation technique. Slow induction of oxygen and nitrous oxide was administered. After the injection phase in protocol 1, nitrous oxide levels were gradually reduced to 0% and only 100% oxygen was delivered till the end of treatment, and in protocol 2, till the end of treatment, 50% nitrous oxide and 50% oxygen were maintained and at the end, 100% oxygen was administered for 5 min. Results: There was no statistically significant difference in physical, physiological, or psychological change in the behavior of anxious children between the two protocols. Conclusions: The interrupted N2O-O2 sedation technique can be effectively used to manage anxious children 4-8 years of age. [ABSTRACT FROM AUTHOR]