Sandler, Carolina X., Gildea, Gabrielle C., Spence, Rosalind R., Jones, Tamara L., Eliadis, Paul, Walker, David, Donaghue, Amanda, Bettington, Catherine, Keller, Jacqui, Pickersgill, Deb, Shevill, Molly, Biggs, Vivien, Morrison, Beth, Jonker, Fiona, Foote, Matthew, Bashford, John, and Hayes, Sandra C.
To determine the safety, feasibility, and potential effect of an 18-week exercise intervention for adults with primary brain cancer. Eligible patients were 12-26-weeks post-radiotherapy for brain cancer. The individually-prescribed weekly exercise was ≥150-minutes of moderate-intensity exercise, including two resistance-training sessions. The intervention was deemed “safe” if exercise-related, serious adverse events (SAE) were experienced by Registration: ACTRN12617001577303 The BRAin Cancer and Exercise (BRACE) study highlights the need for regular monitoring of disease- and treatment-related side effects which may present as barriers to exercise. Exercise prescription should be modified according to the presence and severity of disease- and treatment-related barriers. Adverse events observed, such as dizziness, highlight the importance of supervised exercise for people with brain cancer. If supervision is not possible, then exercise modes with low risk of harm from falls are recommended (e.g., walking, machine-based resistance training).