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Your search keyword '"Du, Hangxiang"' showing total 14 results
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14 results on '"Du, Hangxiang"'

1. Efficacy and safety of Paxlovid in severe adult patients with SARS-Cov-2 infection: a multicenter randomized controlled study

Author

Liu, Jiao, Pan, Xiaojun, Zhang, Sheng, Li, Ming, Ma, Ke, Fan, Cunyi, Lv, Ying, Guan, Xiangdong, Yang, Yi, Ye, Xiaofei, Deng, Xingqi, Wang, Yunfeng, Qin, LunXiu, Xia, Zhijie, Ge, Zi, Zhou, Quanhong, Zhang, Xian, Ling, Yun, Qi, Tangkai, Wen, Zhenliang, Huang, Sisi, Zhang, Lidi, Wang, Tao, Liu, Yongan, Huang, Yanxia, Li, Wenzhe, Du, Hangxiang, Chen, Yizhu, Xu, Yan, Zhao, Qiang, Zhao, Ren, Annane, Djillali, Qu, Jieming, and Chen, Dechang

Published
2023
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2. Low-dose intravenous plus inhaled versus intravenous polymyxin B for the treatment of extensive drug-resistant Gram-negative ventilator-associated pneumonia in the critical illnesses: a multi-center matched case–control study

Author

Liu, Jiao, Shao, Min, Xu, Qianghong, Liu, Fen, Pan, Xiaojun, Wu, Jianfeng, Xiong, Lihong, Wu, Yueming, Tian, Mi, Yao, Jianying, Huang, Sisi, Zhang, Lidi, Chen, Yizhu, Zhang, Sheng, Wen, Zhenliang, Du, Hangxiang, TaoWang, Liu, Yongan, Li, Wenzhe, Xu, Yan, Teboul, Jean-louis, and Chen, Dechang

Published
2022
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6. Corticosteroid treatment in severe COVID-19 patients with acute respiratory distress syndrome

Author

Liu, Jiao, Zhang, Sheng, Dong, Xuan, Li, Zhongyi, Xu, Qianghong, Feng, Huibin, Cai, Jing, Huang, Sisi, Guo, Jun, Zhang, Lidi, Chen, Yizhu, Zhu, Wei, Du, Hangxiang, Liu, Yongan, Wang, Tao, Chen, Limin, Wen, Zhenliang, Annane, Djillali, Qu, Jieming, and Chen, Dechang

Subjects
Coronaviruses -- Health aspects -- Genetic aspects, Corticosteroid drugs -- Dosage and administration -- Patient outcomes, COVID-19 -- Drug therapy -- Complications and side effects -- Patient outcomes, Adult respiratory distress syndrome -- Drug therapy -- Patient outcomes, Health care industry
Abstract

BACKGROUND. Corticosteroids are widely used in patients with COVID 19, although their benefit-to-risk ratio remains controversial. METHODS. Patients with severe COVID-19-related acute respiratory distress syndrome (ARDS) were included from December 29, 2019 to March 16, 2020 in 5 tertiary Chinese hospitals. Cox proportional hazards and competing risks analyses were conducted to analyze the impact of corticosteroids on mortality and SARS-CoV-2 RNA clearance, respectively. We performed a propensity score (PS) matching analysis to control confounding factors. RESULTS. Of 774 eligible patients, 409 patients received corticosteroids, with a median time from hospitalization to starting corticosteroids of 1.0 day (IQR 0.0-3.0 days) . As compared with usual care, treatment with corticosteroids was associated with increased rate of myocardial (15.6% vs. 10.4%, P = 0.041) and liver injury (18.3% vs. 9.9%, P = 0.001), of shock (22.0% vs. 12.6%, P < 0.001), of need for mechanical ventilation (38.1% vs. 19.5%, P < 0.001), and increased rate of 28-day all-cause mortality (44.3% vs. 31.0%, P < 0.001). After PS matching, corticosteroid therapy was associated with 28-day mortality (adjusted HR 1.46, 95% CI 1.01-2.13, P = 0.045). High dose (>200 mg) and early initiation ([less than or equal to] 3 days from hospitalization) of corticosteroid therapy were associated with a higher 28-day mortality rate. Corticosteroid use was also associated with a delay in SARS-CoV-2 coronavirus RNA clearance in the competing risk analysis (subhazard ratio 1.59, 95% CI 1.17-2.15, P = 0.003). CONCLUSION. Administration of corticosteroids in severe COVID-19-related ARDS is associated with increased 28-day mortality and delayed SARS-CoV-2 coronavirus RNA clearance after adjustment for time-varying confounders. FUNDING. None., Introduction SARS-CoV-2 has spread worldwide (1). As of July 17, there were more than 13 million cases and 585,727 deaths worldwide, including over 4000 reported deaths in China (1). There [...]

Published
2020
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12. Efficacy of Thymosin Alpha 1 in the Treatment of COVID-19: A Multicenter Cohort Study

Author

Liu, Jiao, primary, Shen, Yanfei, additional, Wen, Zhenliang, additional, Xu, Qianghong, additional, Wu, Zhixiong, additional, Feng, Huibin, additional, Li, Zhongyi, additional, Dong, Xuan, additional, Huang, Sisi, additional, Guo, Jun, additional, Zhang, Lidi, additional, Chen, Yizhu, additional, Li, Wenzhe, additional, Zhu, Wei, additional, Du, Hangxiang, additional, Liu, Yongan, additional, Wang, Tao, additional, Chen, Limin, additional, Teboul, Jean-Louis, additional, Annane, Djillali, additional, and Chen, Dechang, additional

Published
2021
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