25 results on '"Dunham, Chris"'
Search Results
2. The impact of whole genome and transcriptome analysis (WGTA) on predictive biomarker discovery and diagnostic accuracy of advanced malignancies
- Author
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Tessier‐Cloutier, Basile, Grewal, Jasleen K, Jones, Martin R, Pleasance, Erin, Shen, Yaoqing, Cai, Ellen, Dunham, Chris, Hoang, Lynn, Horst, Basil, Huntsman, David G, Ionescu, Diana, Karnezis, Anthony N, Lee, Anna F, Lee, Cheng Han, Lee, Tae Hoon, Twa, David DW, Mungall, Andrew J, Mungall, Karen, Naso, Julia R, Ng, Tony, Schaeffer, David F, Sheffield, Brandon S, Skinnider, Brian, Smith, Tyler, Williamson, Laura, Zhong, Ellia, Regier, Dean A, Laskin, Janessa, Marra, Marco A, Gilks, C Blake, Jones, Steven JM, and Yip, Stephen
- Subjects
Biomedical and Clinical Sciences ,Oncology and Carcinogenesis ,Genetics ,Cancer ,Rare Diseases ,Human Genome ,4.2 Evaluation of markers and technologies ,Detection ,screening and diagnosis ,Algorithms ,Biomarkers ,Tumor ,Gene Expression Profiling ,Humans ,Neoplasms ,biomarker ,diagnostic ,WGTA ,pathology ,precision medicine ,oncology ,cancer of unknown primary ,machine learning ,Clinical sciences - Abstract
In this study, we evaluate the impact of whole genome and transcriptome analysis (WGTA) on predictive molecular profiling and histologic diagnosis in a cohort of advanced malignancies. WGTA was used to generate reports including molecular alterations and site/tissue of origin prediction. Two reviewers analyzed genomic reports, clinical history, and tumor pathology. We used National Comprehensive Cancer Network (NCCN) consensus guidelines, Food and Drug Administration (FDA) approvals, and provincially reimbursed treatments to define genomic biomarkers associated with approved targeted therapeutic options (TTOs). Tumor tissue/site of origin was reassessed for most cases using genomic analysis, including a machine learning algorithm (Supervised Cancer Origin Prediction Using Expression [SCOPE]) trained on The Cancer Genome Atlas data. WGTA was performed on 652 cases, including a range of primary tumor types/tumor sites and 15 malignant tumors of uncertain histogenesis (MTUH). At the time WGTA was performed, alterations associated with an approved TTO were identified in 39 (6%) cases; 3 of these were not identified through routine pathology workup. In seven (1%) cases, the pathology workup either failed, was not performed, or gave a different result from the WGTA. Approved TTOs identified by WGTA increased to 103 (16%) when applying 2021 guidelines. The histopathologic diagnosis was reviewed in 389 cases and agreed with the diagnostic consensus after WGTA in 94% of non-MTUH cases (n = 374). The remainder included situations where the morphologic diagnosis was changed based on WGTA and clinical data (0.5%), or where the WGTA was non-contributory (5%). The 15 MTUH were all diagnosed as specific tumor types by WGTA. Tumor board reviews including WGTA agreed with almost all initial predictive molecular profile and histopathologic diagnoses. WGTA was a powerful tool to assign site/tissue of origin in MTUH. Current efforts focus on improving therapeutic predictive power and decreasing cost to enhance use of WGTA data as a routine clinical test.
- Published
- 2022
3. Comparative RNA-Sequencing Analysis Benefits a Pediatric Patient With Relapsed Cancer
- Author
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Newton, Yulia, Rassekh, S Rod, Deyell, Rebecca J, Shen, Yaoqing, Jones, Martin R, Dunham, Chris, Yip, Stephen, Leelakumari, Sreeja, Zhu, Jingchun, McColl, Duncan, Swatloski, Teresa, Salama, Sofie R, Ng, Tony, Hendson, Glenda, Lee, Anna F, Ma, Yussanne, Moore, Richard, Mungall, Andrew J, Haussler, David, Stuart, Joshua M, Jantzen, Colleen, Laskin, Janessa, Jones, Steven JM, Marra, Marco A, and Morozova, Olena
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Genetics ,Pediatric Research Initiative ,Pediatric ,Biotechnology ,Pediatric Cancer ,Human Genome ,Rare Diseases ,Cancer ,Oncology and carcinogenesis - Abstract
Clinical detection of sequence and structural variants in known cancer genes points to viable treatment options for a minority of children with cancer.1 To increase the number of children who benefit from genomic profiling, gene expression information must be considered alongside mutations.2,3 Although high expression has been used to nominate drug targets for pediatric cancers,4,5 its utility has not been evaluated in a systematic way.6 We describe a child with a rare sarcoma that was profiled with whole-genome and RNA sequencing (RNA-Seq) techniques. Although the tumor did not harbor DNA mutations targetable by available therapies, incorporation of gene expression information derived from RNA-Seq analysis led to a therapy that produced a significant clinical response. We use this case to describe a framework for inclusion of gene expression into the clinical genomic evaluation of pediatric tumors.
- Published
- 2018
4. Driving success towards zero carbon energy targets for UK’s Local Authorities
- Author
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Turnell, Helen, primary, Marques, Caterina, additional, Jones, Phil, additional, Dunham, Chris, additional, Revesz, Akos, additional, and Maidment, Graeme, additional
- Published
- 2023
- Full Text
- View/download PDF
5. The impact of whole genome and transcriptome analysis (WGTA) on predictive biomarker discovery and diagnostic accuracy of advanced malignancies.
- Author
-
Tessier-Cloutier, Basile, Tessier-Cloutier, Basile, Grewal, Jasleen K, Jones, Martin R, Pleasance, Erin, Shen, Yaoqing, Cai, Ellen, Dunham, Chris, Hoang, Lynn, Horst, Basil, Huntsman, David G, Ionescu, Diana, Karnezis, Anthony N, Lee, Anna F, Lee, Cheng Han, Lee, Tae Hoon, Twa, David Dw, Mungall, Andrew J, Mungall, Karen, Naso, Julia R, Ng, Tony, Schaeffer, David F, Sheffield, Brandon S, Skinnider, Brian, Smith, Tyler, Williamson, Laura, Zhong, Ellia, Regier, Dean A, Laskin, Janessa, Marra, Marco A, Gilks, C Blake, Jones, Steven Jm, Yip, Stephen, Tessier-Cloutier, Basile, Tessier-Cloutier, Basile, Grewal, Jasleen K, Jones, Martin R, Pleasance, Erin, Shen, Yaoqing, Cai, Ellen, Dunham, Chris, Hoang, Lynn, Horst, Basil, Huntsman, David G, Ionescu, Diana, Karnezis, Anthony N, Lee, Anna F, Lee, Cheng Han, Lee, Tae Hoon, Twa, David Dw, Mungall, Andrew J, Mungall, Karen, Naso, Julia R, Ng, Tony, Schaeffer, David F, Sheffield, Brandon S, Skinnider, Brian, Smith, Tyler, Williamson, Laura, Zhong, Ellia, Regier, Dean A, Laskin, Janessa, Marra, Marco A, Gilks, C Blake, Jones, Steven Jm, and Yip, Stephen
- Abstract
In this study, we evaluate the impact of whole genome and transcriptome analysis (WGTA) on predictive molecular profiling and histologic diagnosis in a cohort of advanced malignancies. WGTA was used to generate reports including molecular alterations and site/tissue of origin prediction. Two reviewers analyzed genomic reports, clinical history, and tumor pathology. We used National Comprehensive Cancer Network (NCCN) consensus guidelines, Food and Drug Administration (FDA) approvals, and provincially reimbursed treatments to define genomic biomarkers associated with approved targeted therapeutic options (TTOs). Tumor tissue/site of origin was reassessed for most cases using genomic analysis, including a machine learning algorithm (Supervised Cancer Origin Prediction Using Expression [SCOPE]) trained on The Cancer Genome Atlas data. WGTA was performed on 652 cases, including a range of primary tumor types/tumor sites and 15 malignant tumors of uncertain histogenesis (MTUH). At the time WGTA was performed, alterations associated with an approved TTO were identified in 39 (6%) cases; 3 of these were not identified through routine pathology workup. In seven (1%) cases, the pathology workup either failed, was not performed, or gave a different result from the WGTA. Approved TTOs identified by WGTA increased to 103 (16%) when applying 2021 guidelines. The histopathologic diagnosis was reviewed in 389 cases and agreed with the diagnostic consensus after WGTA in 94% of non-MTUH cases (n = 374). The remainder included situations where the morphologic diagnosis was changed based on WGTA and clinical data (0.5%), or where the WGTA was non-contributory (5%). The 15 MTUH were all diagnosed as specific tumor types by WGTA. Tumor board reviews including WGTA agreed with almost all initial predictive molecular profile and histopathologic diagnoses. WGTA was a powerful tool to assign site/tissue of origin in MTUH. Current efforts focus on improving therapeutic predictive power
- Published
- 2022
6. NTRK2 Fusion driven pediatric glioblastoma: Identification of oncogenic Drivers via integrative Genome and transcriptome profiling
- Author
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Britton, Heidi M., primary, Levine, Adrian B., additional, Shen, Yaoqing, additional, Mungall, Karen, additional, Serrano, Jonathan, additional, Snuderl, Matija, additional, Pleasance, Erin, additional, Jones, Steven J. M., additional, Laskin, Janessa, additional, Marra, Marco A., additional, Rassekh, Shahrad R., additional, Deyell, Rebecca, additional, Yip, Stephen, additional, Cheng, Sylvia, additional, and Dunham, Chris, additional
- Published
- 2021
- Full Text
- View/download PDF
7. Opportunities and Challenges for Implementing Smart Local Energy Systems in Cities and Towns, Demonstrated Through Case Studies.
- Author
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Marques, Catarina, Dunham, Chris, Jones, Phil, Turnell, Helen, Revesz, Akos, and Maidment, Graeme
- Subjects
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CITIES & towns , *HEAT storage , *ELECTRIC vehicle charging stations , *HEAT recovery , *ELECTRIC networks , *SKYSCRAPERS - Abstract
Smart local energy systems (SLES) that integrate heat, power and mobility vectors are part of the UK strategy to reach net zero carbon by 2050. This paper investigates the opportunities and challenges for implementing SLES in cities and towns through case studies in two very different locations in the UK: London and the West Midlands. The blueprint for the GreenSCIES SLES was developed in Islington, London, and consists of a 5 th generation ambient loop district heat network with electric vehicles, storage and solar PV. This network allows for heat sharing between buildings and applications for heat recovery from local sources. A second case study explored the opportunities and challenges for improving a previously proposed conventional 3rd generation district heat network, which connects new developments and existing local authority high-rise apartments in the West Midlands, using the GreenSCIES blueprint. The initial design was expanded to include more existing domestic and non-domestic properties. The study evaluated heat recovery from industrial processes, interseasonal thermal storage in the aquifer and considered the opportunity for adding electric vehicle charging points along the network route. The results show a way to decarbonise heat across the whole area and provide a path to enable the electrification of transport. [ABSTRACT FROM AUTHOR]
- Published
- 2022
8. Pmp22 super-enhancer deletion causes tomacula formation and conduction block in peripheral nerves
- Author
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Pantera, Harrison, primary, Hu, Bo, primary, Moiseev, Daniel, primary, Dunham, Chris, primary, Rashid, Jibraan, primary, Moran, John J, primary, Krentz, Kathleen, primary, Rubinstein, C Dustin, primary, Won, Seongsik, primary, Li, Jun, primary, and Svaren, John, primary
- Published
- 2020
- Full Text
- View/download PDF
9. Integration of High Temperature Heat Networks with Low Carbon Ambient Loop Systems.
- Author
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Marques, Catarina, Dunham, Chris, Jones, Phil, Matabuena, Rodrigo, Revesz, Akos, Lagoeiro, Henrique, and Maidment, Graeme
- Subjects
- *
HIGH temperatures , *HEAT pumps , *WASTE heat , *DATA libraries , *FOSSIL fuels , *CARBON - Abstract
Heat networks are a key technology proposed in the UK Government's Clean Growth Strategy for delivering low carbon and low-cost energy to urban communities in the UK. Currently, around 2% of all heat in the UK is provided by heat networks compared to other countries such as Sweden/Denmark, where they have more than 30% delivered in this way. Most of the Scandinavian systems use high temperature 3rd or 4th generation heat networks (>50-80°C) [>122-176°F] and these are often driven by fossil fuel powered Combined Heat and Power (CHP), which are carbon intensive and also impact on local pollution/particulates. In the UK there is a drive towards 5th generation heat networks involving ambient temperature loops (13 - 25°C) [55-77°F]. These systems deliver additional benefits and savings as they are able to share heat/coolth across the network and capture waste heat from secondary heat sources like the heat from London Underground ventilation shafts and local data centres. They utilise heat pumps to deliver heat or cold from the loop to individual applications or buildings and they avoid emissions of particulates associated with CHP. This paper investigates how existing 3rd and 4th generation networks can be connected into 5th generation systems. It uses the 3rd generation Bunhill CHP installation in the London borough of Islington as a case study to investigate the relative performance when converting a system. The paper describes the techno-economic models developed to show how the Bunhill installation might perform when connected to 5th generation, including CAPEX and engineering connection approaches. [ABSTRACT FROM AUTHOR]
- Published
- 2021
10. Booby prize
- Author
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Dunham, Chris
- Subjects
Geography - Abstract
Thanks to Keith Wilson's article Birds of a Feather in July's issue of Geographical, I realise my new-found interest in photographing seabirds, developed on a recent trip to the Galapagos [...]
- Published
- 2015
11. Pathology, molecular genetics, and epigenetics of diffuse intrinsic pontine glioma.
- Author
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Buczkowicz, Pawel, Hawkins, Cynthia, Giles, Keith, Puliyappadamba, Vinesh, and Dunham, Chris
- Subjects
MOLECULAR genetics ,EPIGENETICS ,GLIOMAS ,CHILDHOOD cancer ,ASTROCYTOMAS ,HISTONES - Abstract
Diffuse intrinsic pontine glioma (DIPG) is a devastating pediatric brain cancer with no effective therapy. Histological similarity of DIPG to supratentorial high-grade astrocytomas of adults has led to assumptions that these entities possess similar underlying molecular properties and therefore similar therapeutic responses to standard therapies. The failure of all clinical trials in the last 30years to improve DIPG patient outcome has suggested otherwise. Recent studies employing next-generation sequencing and microarray technologies have provided a breadth of evidence highlighting the unique molecular genetics and epigenetics of this cancer, distinguishing it from both adult and pediatric cerebral high-grade astrocytomas. This review describes the most common molecular genetic and epigenetic signatures of DIPG in the context of molecular subgroups and histopathological diagnosis, including this tumor entity's unique mutational landscape, copy number alterations, and structural variants, as well as epigenetic changes on the global DNA and histone levels. The increased knowledge of DIPG biology and histopathology has opened doors to new diagnostic and therapeutic avenues. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF
12. Faces in a photo
- Author
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Dunham, Chris
- Subjects
Geography - Abstract
The article on Borneo in the August issue of Geographical (Wild at Heart) caught my eye as I spent a wonderful week in Sarawak last summer. As I turned the [...]
- Published
- 2006
13. Opportunities and Challenges for Low Carbon Heat Supply in Urban Neighbourhoods - A Central London Case Study.
- Author
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Revesz, Akos, Roszynski, Kristina, Dunham, Chris, Jones, Phil, Lagoeiro, Henrique, and Maidment, Graeme
- Subjects
- *
GREENHOUSE gas mitigation , *ENERGY consumption , *POWER resources - Abstract
In 2019, the UK became the first major economy to pass laws to reduce its greenhouse gas emissions to net zero by 2050. Meeting this ambitious target not only requires a shift in energy supply from fossil fuels to low carbon energy sources, but also a reduction in energy demand through the roll-out of energy efficiency improvements to existing buildings. The UK has some of the oldest and most inefficient housing stock in Western Europe and the building sector is responsible for approximately half of energy consumption. The present work has a strong focus on exploring low carbon heat supply tehcnologies could be applied to existing housing stock, using the London Borough of Islington (LBI) as a case study. The applicability of low carbon energy efficiency measures to a range of different building archetype prominent within LBI is discussed and evaluated. The methodology implemented includes both qualitative and quantitative assessment of the opportunities and benefits, with a focus on applicability, cost, and carbon savings associated with two low carbon heat supply options. The overall evaluation approach presented in the paper is applicable to other urban areas in the UK and elsewhere. Key conclusion from the study and planned next steps are also discussed. [ABSTRACT FROM AUTHOR]
- Published
- 2023
14. Inbox.
- Author
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Macilwain, Ian, Groom, Stanley, Jeans, Peter, Westlake, Andy, Dunham, Chris, Wilson, Jeff, and Mallarkey, Gordon
- Published
- 2020
15. Inbox.
- Author
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Anderson, Eric, Harris, Geoff, McKenzie, Peter, Hancox, Liam, Clark, Ian, Dunham, Chris, Gibbs, John, and Westlake, Andy
- Published
- 2019
16. Inbox.
- Author
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Herbert, Andrew, Kimchi, Martin, Gauld, Alan, Macalister, Bruce, Atherton, Nigel, Dunham, Chris, Duder, John, Westlake, Andy, and Lewis, Adrian
- Published
- 2018
17. Inbox.
- Author
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Dunham, Chris, Gale, Brian, Atwell, Oliver, Hosking, Alex, Westlake, Andy, and Wynne-Griffith, Huw
- Published
- 2016
18. Inbox.
- Author
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Douglas, Ian Peter, Mills, Adrian, Lewis, Mark, Sutton, Pete, Sibley, Richard, and Dunham, Chris
- Published
- 2016
19. Inbox.
- Author
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Christie, Roger, Redford, W., Dunham, Chris, Briggs, Robert, Begbie, Eric, Sibley, Richard, and Atherton, Nigel
- Published
- 2015
20. Meeting Net Zero Carbon Emission Targets: A case study tailored to local industry.
- Author
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Marques, Catarina, Turnell, Helen, Jones, Phil, Dunham, Chris, Fox, Matthew, Revesz, Akos, and Maidment, Graeme
- Subjects
- *
CARBON emissions , *HEATING from central stations , *HEAT storage , *NATURAL resources , *MINE water , *HEAT recovery , *SOLAR power plants , *OFFSHORE wind power plants - Abstract
This paper demonstrates the opportunity for UK local authorities to utilise waste heat from local industry to accelerate their success with meeting net zero emissions targets. It presents the results of a feasibility study for an urban area in Yorkshire, UK aimed at driving clean growth and decarbonisation in local industry together with investment in low carbon energy systems. This is an ambient loop district heating network design with sharing of heating between buildings and heat recovery from a local industry source, including mine water. This adapts the GreenSCIES concept developed initially for Islington, London, tailored to local council demands and local industry energy sources. The scheme would be based on a low temperature heat network with large, decentralised heat pumps to raise temperatures to that required in the connected buildings/dwellings. The heat source is low-grade waste-heat from a local glassworks which is readily accessible with minimal disruption to 24/7 operations. The scheme considered thermal storage and the integration of a 20MW solar PV farm and a 10MW windfarm. The results show that that it is possible to decarbonise large parts of the borough including their social housing stock. In addition, using old mine workings as a means of storing and recovering heat, allows seasonal storage of heat to act both as back-up and top-up to the heat available from the glassworks. This novel approach uses natural resources and builds on local industry to accelerate economic regeneration paving the way to net zero carbon emissions. [ABSTRACT FROM AUTHOR]
- Published
- 2023
21. The Importance of Heat Pump COP in the Economics of 5th Generation Heating and Cooling Networks.
- Author
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Revesz, Akos, Lagoeiro, Henrique, Marques, Catarina, Jones, Phil, Dunham, Chris, and Maidment, Graeme
- Subjects
- *
HEAT pumps , *HEATING , *CAPITAL investments , *REFRIGERANTS - Abstract
This paper describes the investigation of heat pumps for GreenSCIES, a 5th Generation heat network in Islington, London. The paper describes the GreenSCIES concept integrating Mobility, Power and Heat into a local energy system. At the heart of the system is a 5th generation heat network, which utilises an ambient heat network to capture secondary heat and share heat between different applications. The GreenSCIES network, technology utilised and buildings connected are described. Heat pumps are used to amplify the temperature of the ambient loop to deliver heat at the required temperature in connected buildings. A number of different heat pumps using different refrigerants and configurations were appraised in this study. This considered the performance, safety, environmental impact, operational and capital expenditure point of view. The study shows the importance of heat pump COP on the economics of operating the system and suggests innovative series arrangements in order to improve performance and economics. [ABSTRACT FROM AUTHOR]
- Published
- 2023
22. Driving Success Towards Zero Carbon Energy Targets for UK's Local Authorities.
- Author
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Turnell, Helen, Marques, Cat, Jones, Phil, Dunham, Chris, Revesz, Akos, and Maidment, Graeme
- Subjects
- *
WASTE heat , *ELECTRIC charge , *HEAT storage , *SERVER farms (Computer network management) , *CARBON emissions , *HEAT recovery , *HOMESITES - Abstract
This paper draws on three recent case studies which have shown encouraging economic results in meeting net-zero carbon emissions targets through Smart Local Energy Systems (SLES) in different localities across England, based on the GreenSCIES model. The blueprint for the GreenSCIES SLES was developed in Islington, London, and consists of a 5th generation ambient loop district heat network using heat from a large data centre, also including electric vehicle charging, storage and solar PV. This allows for heat sharing between buildings and applications for heat recovery from local sources. In Sandwell, Birmingham, where the heating demand is nearly ten times higher than the cooling demand the design is based on a 4th generation heat network with waste heat from a local metal foundry and some cooling supply and heat storage in the aquifer. The design for a study in Barnsley, Sheffield, explored waste heat from a local glass factory and considered old mine workings as a means of storing and recovering heat, providing seasonal storage of heat for resilience to a single source industry. With additional work, the Barnsley scheme could be further expanded, increasing the available carbon emissions savings. These examples provide practical, feasible and economic SLES projects which demonstrate the importance of collaboration between researchers, local government and industry. They also illustrate how the original GreenSCIES concept can be adapted successfully to provide a pathway towards netzero carbon for a diverse range of urban locations with different housing density and waste heat sources. [ABSTRACT FROM AUTHOR]
- Published
- 2023
23. The quest to secure inter-office networking.
- Author
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Dunham, Chris and Kyrillou, John
- Subjects
OFFICE management ,BUSINESS networks ,INFORMATION technology - Abstract
The article focuses on the networking solution provided by Exponential-e Ltd. to Interquest Group PLC. A brief overview on the inter-company network problems of InterQuest is offered which focuses on the merger of offices. Changes to the information technology (IT) infrastructure of InterQuest facilitated by Exponential are outlined.
- Published
- 2013
24. Optimisation of Smart Local Energy Systems with Aquifer Thermal Energy Storage in Cities.
- Author
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Revesz, Akos, Williams, Huw, Findlay, John, Dunham, Chris, Jones, ,Phil, Moggeridge, Michael, Riddle, Anthony, and Maidment, Graeme
- Subjects
- *
HEAT storage , *GEOLOGICAL carbon sequestration , *AQUIFERS , *HYDROGEOLOGY , *BOREHOLES - Abstract
This paper provides an overview of a systematic approach for the performance optimisation of smart local energy systems (SLES) using central London, UK as a case study. Key components of the SLES are linked in decentralised energy centres, which are connected through an ultra-low temperature (also called ambient loop) 5th generation heating & cooling (5DHC) network. The 5DHC approach requires a means of balancing the heat and coolth in the ambient loop. This work has identified that the introduction of Aquifer thermal energy stores (ATES) system could be a novel way of achieving that balancing mechanism as well as to provide heat and coolth store interseasonally. This paper describes a comprehensive study, which investigated the potential of using the London aquifer system for supplying and balancing the thermal loads of a 5DHC network in Central London. The paper first introduces a currently ongoing detailed design project called GreenSCIES - Green Smart Community Integrated Energy Systems. Then it presents the methodology applied for evaluating the opportunity for implementing and optimising the scheme making use of an ATES system. Results of novel and comprehensive numerical groundwater modelling of the ATES system behaviour at the proposed location are presented and discussed in detail. Furthermore, the results are discussed in relation to optimal location, design and operational regime of the boreholes in order to achieve maximum performance of the proposed 5DHC scheme. [ABSTRACT FROM AUTHOR]
- Published
- 2022
25. Initial Assessment of a 5th Generation District Energy Network in Central London.
- Author
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Revesz, Akos, Marques, Catarina, Davies, Gareth, Matabuena, Rodrigo, Jones, Phil, Dunham, Chris, and Maidment, Graeme
- Subjects
- *
ENERGY demand management , *HEAT storage , *HEAT pumps , *PERFORMANCE technology , *GENERATIONS , *5G networks - Abstract
The paper introduces a concept design for the UK's first large-scale fifth generation (5G) smart energy network using an area in central London as a case study. The proposed system will incorporate a range of different renewables and secondary energy sources that will supply a large proportion of the energy demand of the overall district network capacity. The network will operate at close to ambient temperature, approximately 15-25°C (59-77°F) as a single loop system, with individual heat pumps for each end user or building connected to the network. The system also integrates thermal and electrical storage to create additional flexibility for the network and smart control for demand-side management. The paper describes the proposed 5G network concept and details the selected components of the system, in particular urban location. Key outcomes of the study presented in this paper provide understanding of the relative performance of individual technologies in a complex system using a techno-economic modelling approach. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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