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Background Women's reproductive history has been recognized as a cardiovascular risk factor and risk enhancer. Purpose To compare ideal cardiovascular health (CVH) metrics across multiple women's health conditions: parity, breastfeeding, hormonal contraceptive use and menopause status. Methods Cross-sectional data were collected from 7034 women, age 45 to 64 years, free of CVD. Using the 7 American Heart Association criteria, we defined CVH as ideal, intermediate or poor if 6–7, 3–5 or 0–2 ideal metrics were met, respectively. We calculated the CVH score, ranging from 7 (all metrics poor) to 21 (all metrics ideal). Reproductive history was self-reported. We categorized parity in four categories (0, 1–2, 3–4 and 5 or more births). We used general linear models and proportional odds regression models to adjust for covariates and to assess mediation by age, education, income and urban/rural residence. Results Women had a mean age of 55.1 years (SD 5.3). The prevalence of nulliparity was 8.4%, menopause 75.49% and ever use of oral contraceptives, 12.8%. Among non-nulliparous, 88.9% breastfed for a median cumulative duration of 10 months. The prevalence of traditional CVD risk factors was high (obesity 27.6%, uncontrolled blood pressure 39.8%, poor diet 38%). The prevalence of ideal, intermediate and poor CVH was 0.1%, 41.7% and 58.2% respectively. None of the participants had all 7 cardiovascular health metrics at ideal level. Average CVH score was 14.1 (SD 1.9). The prevalence of intermediate CVH scores was highest among nulliparous (27.6%) and decreased with parity (26.72%, 19.87% and 11.42%). There was a statistically significant gradient in mean age-adjusted CVH score across the four parity categories, increasing from multiparous of 5 or more births (13.36, 95% CI 13.13–13.60) to nulliparous (14.24, 95% CI 14.08–14.39). Nulliparous women had 2.9 times greater odds (95% CI 1.91–4.54) of higher CVH scores than multiparous of 5 or more births, after adjusting for age, menopause and use of hormonal contraceptives. Similarly, for women who gave birth 1–2 times and 3–4 times, the adjusted relative odds were 2.65 (95% CI 1.78–3.94) and 1.80 (95% CI 1.2–2.71), respectively. Further adjustment for education, rural residence, personal and/or household finance status attenuated these relations, suggesting a mediating effect. Among non-nulliparous, neither ever breastfeeding or cumulative duration of breastfeeding were associated with CVH scores. Premenopausal women had 1.56 (95% CI 1.33–1.84) times higher odds of higher CVH scores then postmenopausal ones, after full adjustment. Conclusion Women's reproductive history, particularly parity is associated with middle-age cardiovascular health, and part of the association is explained by socio-economic status. These findings suggest the need for early screening and intensification of preventive cardiology interventions in women, especially among vulnerable subgroups. Funding Acknowledgement Type of funding sources: Foundation. Main funding source(s): The Polish-Norwegian Research Fund (PNRF-228-AI-1/07)

Funding Acknowledgements Type of funding sources: None. BACKGROUND Although endogenous sex hormones influence both left atrial (LA) and left ventricular (LV) structure in peri-menopausal women, no study has ever evaluated the interaction between sex hormones levels and the left atrioventricular coupling. PURPOSE This study aimed to assess the prognostic value of a left atrioventricular coupling index (LACI) in pre- and post-menopausal women without history of CVD at baseline. METHODS In all women participating in the Multi-Ethnic Study of Atherosclerosis (MESA) with baseline cardiovascular magnetic resonance (CMR) study, LACI was measured as the ratio of the LA end-diastolic volume divided by the LV end-diastolic volume. Cox proportional hazard models were used to assess the association between LACI and the outcomes of atrial fibrillation (AF), heart failure (HF), coronary heart disease (CHD) death, and hard CVD defined by myocardial infarction, resuscitated cardiac arrest, stroke, or CHD death. In multivariable analyses, the associations between LACI and the time-to-event were evaluated, adjusting for demographics, traditional cardiovascular risk factors, menopausal status and sex hormone levels. RESULTS Among the 2,087 women (61.2 ± 10.1 years), 485 cardiovascular events were observed during mean follow-up period of 13.2 ± 3.3 years. Greater LACI was independently associated with AF (HR 1.70; 95% CI [1.51-1.90]), HF (HR 1.62; 95% CI [1.33-1.97]), CHD death (HR 1.36; 95% CI [1.10-1.68]), and hard CVD (1.30; 95% CI [1.13-1.51], all p CONCLUSIONS In a multi-ethnic population of pre- and post-menopausal women, LACI is an independent predictor of HF, AF, CHD death and hard CVD. In both pre- and post-menopausal women, LACI has an incremental prognostic value to predict cardiovascular events over traditional risk factors and sex hormone levels. ClinicalTrials.gov Identifier: NCT00005487 Abstract Figure. Kaplan-Meier curves by LACI terciles Abstract Figure. Kaplan-Meier curves by LACI and Menop.

Background and aim A measles outbreak occurred in Greece during 2017–2018 affecting mainly pediatric population. The aim of the study was to describe the epidemiological and clinical characteristics of the cases diagnosed in the major pediatric tertiary hospital of Athens, where 26.5% of national pediatric measles cases were diagnosed and treated. Methods This is a retrospective study of children 0–16 years old, who presented at the emergency department and/or were hospitalized with clinical presentation compatible with measles and diagnosis was confirmed with molecular detection of the measles RNA in pharyngeal swabs. Epidemiological, clinical and laboratory characteristics were retrieved from medical records and analyzed. Results A total of 578 children with measles were identified during the study period. 322 (55.7%) were male with median age 36 months (range:1–193), while the largest number of documented cases (251; 43.4%) were children aged 1–5 years. Most children (429/578; 74.2%) belonged to the Roma minority and only 64 (11.1%) had Greek origin. 497 (91.5%) children were unvaccinated and 37 (6.8%) were partially vaccinated with measles vaccine. Hospitalization was required for 342 (59.2%) children, whereas one or more complications were reported in 230 (67.2%) of them. Most frequent complications were elevated transaminases (139; 40.6%), acute otitis media (72; 21%), dehydration (67; 19.6%) and pneumonia (58; 16.9%). 11 children (3.2%) required intensive care admission for altered mental status/status epilepticus (3), sepsis (2) and ARDS (6). 119/342 (34.8%) children were treated with antibiotics because of possible or confirmed bacterial coinfection. One death was reported, concerning an 11-month-old unvaccinated infant, with underlying dystrophy, who died of sepsis. Conclusion Measles is not an innocent viral infection, as it is still characterized by high morbidity and complications rates. Unvaccinated or partially vaccinated populations could trigger new outbreaks, resulting in significant cost in public health. To avoid future measles outbreaks, high vaccination coverage should be achieved, as well as closing immunity gaps in the population and ensuring high-quality measles surveillance. Copyright: © 2021 Gianniki et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Background: To evaluate the performance of serum amyloid-A (SAA), high-density lipoprotein cholesterol (HDL-C) and apolipoprotein-A1 (Apo-A1) levels in the identification and monitoring of neonatal sepsis. Methods: This prospective study included 113 full-term septic neonates (postnatal age 4-28 days) admitted to the Special Care Neonatal Unit of a University Hospital from January 1, 2016, to April 30, 2019, and 68 healthy neonates (controls). Blood samples were drawn serially in septic neonates at enrollment and on days 1, 3 and 7, and once in controls, for SAA, HDL-C and Apo-A1 determination. Results: At enrollment, SAA levels were significantly higher in septic neonates in comparison with controls (median 50.7 vs. 3.5 mg/L; P < 0.0001); HDL-C and Apo-A1 levels were significantly lower in patients than in controls (P < 0.001 and P < 0.006, respectively). SAA levels were higher in culture-positive compared with culture-negative sepsis (median 202.0 vs. 14.2 mg/L; P < 0.0001). HDL-C and Apo-A1 levels did not differ significantly between culture-positive and culture-negative sepsis. Receiver operating characteristic curve analysis of SAA levels at enrollment resulted in significant areas under the curve (AUC) for detecting sepsis {AUC = 0.929 [95% confidence interval: 0.885-0.973]; P < 0.0001} and also for discriminating between culture-positive and culture-negative sepsis [AUC = 0.933 (95% confidence interval: 0.882-0.984); P < 0.0001]. The combination of HDL-C and Apo-A1 with SAA increased its diagnostic performance. Furthermore, serial SAA levels following enrollment could indicate clinical response in septic neonates. Conclusions: SAA seems to be a useful biomarker for identification and monitoring of neonatal sepsis, and also for discriminating between culture-positive and culture-negative sepsis. HDL-C and Apo-A1 could be used as complementary markers. © 2020 Wolters Kluwer Health, Inc.

The objective of this study is to analyze the kinetic and kinematic changes of the osteoarthritic knee after a mobile bearing total knee arthroplasty. Kinematic and kinetic gait analysis of level walking was performed in 15 patients (eight female and seven male) with knee ostoarthritis. All patients were free of any neurological diseases that could affect their normal gait. Mean age was 68.6 ± 5.2 years, mean height 159.8 ± 6.9 cm, and mean weight was 78.5 ± 10.1 kg. Full body gait analysis was performed using the BioKin three-dimensional (3D) motion analysis system preoperatively and 9 months after total knee arthroplasty. A single-step ascending kinetic analysis and a plantar pressure distribution analysis were also performed in all patients. An increased average cadence (mean 99.39 step/min preoperatively and 104.64 step/min postoperatively; p = 0.152), step length (0.44 m preoperatively and 0.52 m postoperatively; p < 0.001), stride length (0.89 m preoperatively and 1.0 m postoperatively; p < 0.007), and walking velocity (0.73 m/sec preoperatively and 0.90 m/sec postoperatively; p = 0.005) were noted postoperatively and postoperatively. A decrease in the stance duration percentage and the knee adduction moment was also reported postoperatively. All patients showed a significant improvement of knee kinetics and kinematics after a mobile bearing total knee arthroplasty. Statistically significant differences were found in the step length, stride length, and walk velocity postoperatively. The knee adduction moment was also significantly reduced. Further research is warranted to determine the clinical relevance of these findings. This study is a prospective comparative one and reflects level II evidence. © 2020 Georg Thieme Verlag. All rights reserved.

Language barriers present a major problem in the effectiveness of resource sharing and in common access to the resources of libraries. In this paper we present the TRANSLIB system, which consists of an integration of both new and existing multilingual information tools. This system takes full advantage of some AI-based methods in order to provide multilingual access to library catalogues. Its main features include functionalities for searching in multiple languages, multilingual presentation of the query results, and localization of the user interface. TRANSLIB has currently been tested in existing medium-sized bibliographic databases. Evaluation results show a remarkable improvement in the search process and report high user friendliness and easy and low-cost maintenance and upgrade of the system.

Text retrieval techniques have long focused on the topic of texts rather than the pragmatic role they play per se. In this article, we address two other aspects in text processing that could enhance text retrieval: (a) the detection of functional style in retrieved texts, and (b) the detection of writer"s attitude towards a given topic in retrieved texts. The former is justified by the fact that current text databases have become highly heterogeneous in terms of document inclusion, while the latter is dictated by the need for advanced and intelligent retrieval tools. Towards this aim, two generalised methodologies are presented in order to achieve the implementation of the findings in both aspects in text processing respectively. Particularly, the first one is fully developed and thus is analysed and evaluated in detail, while for the second one the theoretical framework is given for its subsequent computational implementation. Both approaches are as language independent as possible, empirically driven, and can be used, apart from information retrieval purposes, in various natural language processing applications. These include grammar and style checking, natural language generation, summarisation, style verification in real-world texts, recognition of style shift between adjacent portions of text, and author identification.

This paper deals with the problems stemming from the parsing of long sentences in quasi free word order languages. Due to the word order freedom of a large category of languages including Greek and the limitations of rule-based grammar parsers in parsing unrestricted texts of such languages, we propose a flexible and effective method for parsing long sentences of such languages that combines heuristic information and pattern-matching techniques in early processing levels. This method is deeply characterized by its simplicity and robustness. Although it has been developed and tested for the Greek language, its theoretical background, implementation algorithm and results are language independent and can be of considerable value for many practical natural language processing (NLP) applications involving parsing of unrestricted texts.

Rotavirus is the leading cause of acute gastroenteritis among young children worldwide. A prospective multi-center study was conducted (2007-2008) in five Pediatric Hospitals to determine the prevalence, the clinical characteristics, and genotype distribution of rotavirus infection in Greece. Faecal samples were examined for the presence of group A rotavirus antigen by immunochromatography. Rotavirus strains were subjected to G and P genotyping by reverse-transcriptase polymerase chain reaction (PCR) and sequencing. A total of 393 children (216 boys) of median age 23 months, participated in the study. Rotavirus was the cause of acute gastroenteritis in 166 children, 42.3% (CI 95%, 37.4-47.1%) of non-hospitalized and 47.8% (CI 95%, 41.7-53.9%) of hospitalized patients. Rotavirus gastroenteritis occurred between December and April in 78.6% of the cases. Most children with RVG (77.8%) were between 3 months and 3 years old. The mean value of Clark severity score was 12.9 ± 5.1 for RVG and 10.5 ± 4.9 for non-RVG (P < 0.01). Genotypes were determined in 117 strains and their distribution was as following: G1P[8], 49%; G2P[4], 31%; G4P[8], 10%; G9P[8], 9%; and G8P[14], 1%. In conclusion, rotavirus is a frequent cause of acute gastroenteritis in Greece. The genotypes circulating are similar with those of other European countries. Copyright © 2010 Wiley-Liss, Inc.

To investigate whether single nucleotide polymorphisms (SNPs) in key cytokine and innate immunity genes influence risk for childhood lymphomas, we genotyped 37 children with Hodgkin's (HL) and 48 with non-Hodgkin's lymphoma (NHL), aged (1 month-14 yr), along with their 85 age- and gender-matched controls suffering from mild medical conditions. Genotypic analysis was performed for 10 SNPs from nine genes with important role in immunoregulatory pathways (IL4, IL4R, IL6, IL10, IL12, IL18, TNFα, IFNγ, CD14). Analysis of SNPs genotypes revealed that the CD14 -159 C>T polymorphism was associated with significantly increased risk for HL regarding both the CC and CT genotypes (OR CC: 5.36; 95% CI, 1.30-22.14; P = 0.02, OR CT: 3.76; 95% CI, 1.00-14.16; P = 0.05). An indicative association between IL18-137 G>C polymorphism with the CC genotype and NHL did not reach, however, statistical significance (OR CC, 3.78; 95% CI, 0.87-16.38; P = 0.08). In conclusion, our findings suggest that genetic variation in the CD14-159 loci may be associated with childhood HL risk; these preliminary findings need to be further confirmed in sizeable multi-centre studies along with determination of cytokines, which could provide an insight on the biologic basis underlying these findings. © 2009 John Wiley & Sons A/S.

A time-based sequential dispensing on-line column preconcentration procedure for mercury determination at trace levels by cold vapour generation inductively coupled plasma atomic emission spectrometry (CV-ICP-AES), by means of a unified module of a preconcentration column and a gas-liquid separator (PCGLS) is described. The complex of mercury formed on-line with ammonium pyrrolidine dithiocarbamate (APDC) is retained on the surface of the hydrophobic poly(tetrafluoroethylene) (PTFE) turnings, which are packed into the lower compartment of the PCGLS. Subsequently, mercury vapour is generated directly on the PTFE turnings by reductant SnCl(2) and separated from the liquid mixture via the PCGLS by argon purge gas. The outlet of the PCGLS is connected directly to the torch adapter of the plasma without the normal spray chamber and nebulizer. With 60-s preconcentration time and 12.0 mL min(-1) sample flow rate, the sampling frequency is 30 h(-1). The calibration curve is linear over the concentration range 0.02-5.0 microg L(-1), the detection limit ( c(L)) is 0.01 microg L(-1) and the relative standard deviation ( s(r)) is 3.1% at the 1.0 microg L(-1) level. The proposed method was evaluated by analysis of BCR CRM 278 (Mytilus Edulis) reference material and applied to the determination of total mercury in digested urine, blood and hair samples.