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Author(s): Khadiga M. Kelani [sup.1] [sup.2], Mamdouh R. Rezk [sup.1], Ahmed S. Saad [sup.1] [sup.3], Menna S. ElSherbiny [sup.2], Hany H. Monir [sup.1] Author Affiliations: (1) grid.7776.1, 0000 0004 0639 [...], Two spectrometric methods and a TLC-densitometric method are described for the determination of hyoscine/ketoprofen combination. A new spectrophotometric method called the co-absorptive point has been explained based on the idea of the isosbestic point. This method has been introduced to resolve the overlapped spectra and the challenging drug ratios found in the mentioned dosage form. Also, a dual wavelength technique measuring at 208.4 and 218.2 nm was explained. In the two spectrometric techniques, ketoprofen was determined by zero-order spectra, while hyoscine was determined by co-absorptive point and dual wavelength techniques with linearity ranges of 8-100 and 8-70 [micro]g/mL. In the TLC-densitometric method, the developing phase was methanol-ethyl acetate-ammonia (35 : 65 : 5, v/v) with linearity ranges of 1-20 and 5-25 [micro]g/mL for hyoscine and ketoprofen, respectively. The greenness of the described techniques was assessed according to the eco-scale and compared to previously reported methods.