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1. Osteoplastic biomaterials from organic and mineral components of the bone matrix: a literature review

Author

Pavel А. Markov, Petr S. Eremin, Elena S. Berezkina, Marina V. Volkova, Irina A. Usova, and Ilmira R. Gilmutdinova

Subjects
collagen, hydroxyapatite, tricalcium phosphates, biocomposite, bioceramics, Medicine (General), R5-920, Sports medicine, RC1200-1245
Abstract

Introduction. The bones of the human and animal have a unique ability to remodel. The ability to constantly renew bone tissue determines the healing of fractures and the adaptation of bones to mechanical loads. However, the process of bone self-healing is effective only for defects of non-critical size. In segmental and critical defects, endogenous stimulation of bone tissue regeneration is required. In this regard, there remains a need to design osteoplastic biomaterials with improved pro-regenerative action. Every year, new data appear that expand our understanding of the methods and mechanisms for stimulating bone tissue restoration using artificial osteoplastic materials. Aim. Characteristics of modern methods of constructing biomimetic materials from organic and mineral components of bone matrix. Materials and methods. The literature review was conducted using the PubMed and ScienceDirect databases. Query dates — may–july 2024, query depth — 1965–2024. Main content of the review. Effective use of bone polymers for the creation of biomimetic osteoplastic materials is possible only with an understanding of the principles of molecular-cellular interaction of biopolymers with bone cells and tissues. By now, it has been established that the ability of collagen to influence the functional activity of cells involved in the reparative regeneration of bone tissue is due to the presence of special patterns in its structure - binding sites with cellular receptors, which are formed by a specific sequence of amino acids in the collagen polypeptide chain. In the case of inorganic bone material, the functionally significant elements are the chemical composition and crystal structure of calcium phosphate salts. A current trend in the design of osteoplastic materials is to impart biomimetic properties to them. At the molecular level, this approach is implemented using as intrafibrillar and extrafibrillar mineralization of collagen fibrils. At the tissue and organ level, biomimicry is achieved through the use of three-dimensional bioprinting technologies. Conclusion. Thus, thanks to advances in biology, physics, chemistry and engineering sciences, it was possible to develop new technologies for designing osteoplastic materials that imitate the structure and function of native bone tissue. The use of biomaterials created using biomimetics principles increases the efficiency of bone tissue damage restoration.

Published
2024
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2. New non-drug technologies for lymphedema associated with breast cancer: a review

Author

Tatiana V. Apkhanova, Tatiana V. Konchugova, Detelina B. Kulchitskaya, Olga V. Yurova, Elena M. Styazhkina, Tatyana V. Marfina, Lev G. Agasarov, Valeriia A. Vasileva, and Elena S. Berezkina

Subjects
arm lymphedema, breast cancer, rehabilitation, manual lymphatic drainage, intermittent pneumocompression, Medicine (General), R5-920, Sports medicine, RC1200-1245
Abstract

INTRODUCTION. Breast Cancer-Related Lymphedema (BCRL) is the most common complication after radical treatment of breast cancer (BC). Currently, there are no molecular therapeutic targets whose pharmacologic action could prevent edema, making it necessary to study the efficacy of non-pharmacologic techniques. AIM. To study the effectiveness of non-medication technologies in BCRL to develop recommendations for practical application based on the analysis of systematic reviews and meta-analyses of randomized controlled trials (RCTs). MATERIALS AND METHODS. The search was conducted in the Physiotherapy Evidence-Based Database (PEDro, 2002–2024) using the keywords: “lymphedema”, “upper limbs”, “breast cancer”. A total of 203 sources were selected as of March 2024. RESULTS AND DISCUSSION. Numerous studies have found that the use of early postoperative physical exercise with a gradual expansion of the load in patients at risk of developing BCRL is a safe and effective method of rehabilitation. The effectiveness of early preventive use of manual lymphatic drainage (MLD) in 4 RCTs was studied in a Cochrane review. However, the clinical effectiveness of early prophylactic use of MLD to prevent BCRL remains insufficiently proven. In contrast, prophylactic use of compression sleeves has been shown to reduce and delay the onset of arm lymphedema in women at high risk of developing BCRL during the first year after breast cancer surgery. Studies have also confirmed the effectiveness of an early Prospective Surveillance Model using bioimpedance spectroscopy for early detection and immediate treatment of BCRL. It has been proven that in order to reduce the volume of a limb with BCRL, it is necessary to prescribe an intensive phase of complex decongestive therapy (CDT) for at least 3 weeks. Studies have also proven the effectiveness of using a standard or improved intermittent pneumatic compression device in the rehabilitation phases, including at home. CONCLUSION. To reduce the risk of development and progression of BCRL, modern exercise therapy techniques should be used to increase physical activity in order to control body weight, and educational techniques for self-massage and self-application of compression bandages should be actively used. The “golden” standard for conservative treatment of BCRL remains CDT, which is based on MLD. At the same time, the wider use and development of new methods of hardware lymphatic drainage that imitate MLD, which is a highly resourceful and costly method of treatment for BCRL, is justified. To confirm the clinical effectiveness of improved hardware pneumocompression, additional RCTs assessing long-term treatment results are required.

Published
2024
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3. Ecological and physiological assessment of the elemental status in the adult population of the Republic of Bashkortostan

Author

Margarita G. Skalnaya, Anatoly V. Skalny, Vasily A. Demidov, A.R. Grabeklis, and Elena S. Berezkina

Subjects
Index (economics), Health, Toxicology and Mutagenesis, Public Health, Environmental and Occupational Health, Adult population, General Medicine, 030204 cardiovascular system & hematology, Pollution, The Republic, 03 medical and health sciences, 0302 clinical medicine, Geography, Reference values, National system, Environmental health, 030211 gastroenterology & hepatology, Russian federation
Abstract

The study of elemental status was carried out as a result of a multielement analysis of hair by ICP-MS within the framework of the Federal Program "National System of chemical and biological security of the Russian Federation, 2009-2014". This parameter is an index of the impact of the environment on the body. A total of 1,138 adult residents of the Republic of Bashkortostan (624 women and 514 men aged of25-50 years) were examined. The features of the element status of the adult population of the Republic were shown. The obtained data can be used as reference values of chemical elements in the hair of the adult population of the Republic of Bashkortostan.

Published
2019
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4. The effect of alcohol consumption on maternal and cord blood electrolyte and trace element levels

Author

Elena S. Berezkina, E. V. Kiyaeva, Andrew R Grabeklis, Alexey A. Tinkov, Inara E. Alidzhanova, and Anatoly V. Skalny

Subjects
Fetus, medicine.medical_specialty, Pregnancy, Offspring, Fetal alcohol syndrome, Physiology, Alcohol, medicine.disease, Umbilical cord, Surgery, chemistry.chemical_compound, medicine.anatomical_structure, chemistry, Cord blood, medicine, Food Science, Whole blood
Abstract

Background Earlier studies demonstrated that alcoholism significantly alters electrolyte and trace element homeostasis. However, the existing data on the interplay between maternal alcohol consumption and fetal trace element status are contradictory. Therefore, the primary objective of the present study was to assess the influence of alcohol consumption on maternal and cord blood trace elements. Methods A total of 30 pregnant women (15 women consuming alcohol and 15 controls) were examined. Assessment of electrolyte and trace elements concentration in maternal (1 and 3 trimesters) and umbilical cord blood was performed using inductively-coupled plasma mass spectrometry. Results In the first trimester of pregnancy alcohol consumption is associated with increased whole blood Ca and Na levels. In the third trimester of pregnancy, women consuming alcohol are characterized by significantly increased Co levels. Conversely, the level of Co and Mn in the cord blood of offspring maternally exposed to ethanol is decreased. A significant correlation between first trimester blood and cord blood concentrations of K was revealed both in control women and those consuming alcohol. In the third trimester of pregnancy in the control women, a significant correlation with cord blood was detected for Fe, Mg, P, and Pb. Oppositely, in the third trimester in women consuming alcohol we detected a close association between maternal whole blood and cord blood levels for Ca, Cd, and Pb. Conclusions The data obtained demonstrate that maternal alcohol consumption results in fetal Co and Mn deficiency.

Published
2016
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5. CONTENT OF CHEMICAL ELEMENTS IN HAIR OF MOSCOW CHILDREN: RELATION TO ILLNESS (1995-2004)

Author

Eugeny P. Serebryansky, Yu.N. Lobanova, Anatoly V. Skalny, Elena S. Berezkina, Vasily A. Demidov, Margarita G. Skalnaya, and A.R. Grabeklis

Subjects
03 medical and health sciences, 0302 clinical medicine, Chemistry, 010501 environmental sciences, Content (Freudian dream analysis), Relation (history of concept), 01 natural sciences, 030217 neurology & neurosurgery, 0105 earth and related environmental sciences, Developmental psychology
Published
2016
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6. The effect of alcohol consumption on maternal and cord blood electrolyte and trace element levels

Author

Anatoly V, Skalny, Elena S, Berezkina, Elena V, Kiyaeva, Inara E, Alidzhanova, Andrew R, Grabeklis, and Alexey A, Tinkov

Subjects
Adult, Manganese, Alcohol Drinking, Iron, Pregnancy Trimester, Third, Sodium, Cobalt, Fetal Blood, Trace Elements, Electrolytes, Pregnancy Trimester, First, Young Adult, Lead, Pregnancy, Case-Control Studies, Potassium, Humans, Calcium, Female, Cadmium
Abstract

Earlier studies demonstrated that alcoholism significantly alters electrolyte and trace element homeostasis. However, the existing data on the interplay between maternal alcohol consumption and fetal trace element status are contradictory. Therefore, the primary objective of the present study was to assess the influence of alcohol consumption on maternal and cord blood trace elements.A total of 30 pregnant women (15 women consuming alcohol and 15 controls) were examined. Assessment of electrolyte and trace elements concentration in maternal (1 and 3 trimesters) and umbilical cord blood was performed using inductively-coupled plasma mass spectrometry.In the first trimester of pregnancy alcohol consumption is associated with increased whole blood Ca and Na levels. In the third trimester of pregnancy, women consuming alcohol are characterized by significantly increased Co levels. Conversely, the level of Co and Mn in the cord blood of offspring maternally exposed to ethanol is decreased. A significant correlation between first trimester blood and cord blood concentrations of K was revealed both in control women and those consuming alcohol. In the third trimester of pregnancy in the control women, a significant correlation with cord blood was detected for Fe, Mg, P, and Pb. Oppositely, in the third trimester in women consuming alcohol we detected a close association between maternal whole blood and cord blood levels for Ca, Cd, and Pb.The data obtained demonstrate that maternal alcohol consumption results in fetal Co and Mn deficiency.

Published
2017

7. Hair concentration of essential trace elements in adult non-exposed Russian population

Author

Andrey A. Skalny, Alexandr A. Nikonorov, Yulia N. Lobanova, Vasily A. Demidov, Elena S. Berezkina, Nikolay G Zhivaev, Eugeny P. Serebryansky, Margarita G. Skalnaya, Alexey A. Tinkov, Irina V Gryazeva, Anatoly V. Skalny, Andrei R. Grabeklis, and Oksana A. Skalnaya

Subjects
Adult, Male, Management, Monitoring, Policy and Law, Russia, Reference Values, Biomonitoring, Humans, Inductively coupled plasma mass spectrometry, General Environmental Science, Chemistry, Spectrum Analysis, Trace element, Environmental Exposure, General Medicine, Environmental exposure, Middle Aged, Pollution, Trace Elements, Metals, Reference values, Environmental chemistry, Russian population, Female, Metalloid, Spectrum analysis, Environmental Monitoring, Hair
Abstract

Appropriate reference values of hair trace element content are required for correct interpretation of biomonitoring data. The primary objective of the current study was to estimate the reference values of selected essential trace elements in hair of adult Russian population. Involved in current investigation were 7256 occupationally non-exposed adults aged from 20 to 60 years and living in the European part of Russia. Occipital hair essential metal and metalloid (Co, Cr, Cu, Fe, Mn, Se, V, Zn) content was estimated using inductively coupled plasma mass spectrometry. The reference ranges were calculated in accordance with the International Union of Pure and Applied Chemistry (IUPAC) recommendations. Women were characterized by 55, 18, 58, and 7% higher values of hair Co, Cu, Mn, and Zn content as compared to the values observed in men. At the same time, hair Cr, Fe, Se, and V concentration in men significantly exceeded the respective female values by 65, 13, 20, and 56%. Consequently, the reference ranges of essential hair trace elements content should be separately calculated for both men and women. The obtained reference ranges for hair Co, Cr, Cu, Fe, Mn, Se, V, and Zn in men were 0.11-0.67, 0.007-0.045, 10.4-22.6, 11.1-40.5, 0.24-1.05, 0.089-0.480, 0.014-0.083, and 125.7-262.8 μg/g, respectively. The respective values estimated for women were 0.06-0.40, 0.011-0.085, 12.1-44.5, 8.9-25.6, 0.32-2.05, 0.094-0.504, 0.010-0.056, and 140.0-315.1 μg/g. The reference ranges for hair Co (0.07-0.50), Cr (0.009-0.073), Cu (11.8-29.2), Fe (9.6-31.5), Mn (0.29-1.76), Se (0.093-0.482), V (0.011-0.069), and Zn (134.7-301.9) content (μg/g) in the general cohort were also calculated.

Published
2015
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8. Reference values of hair toxic trace elements content in occupationally non-exposed Russian population

Author

Margarita G. Skalnaya, Yulia N. Lobanova, Alexey A. Tinkov, Alexandr A. Nikonorov, Elena S. Berezkina, Andrei R. Grabeklis, Anatoly V. Skalny, Andrey A. Skalny, Irina V Gryazeva, Eugeny P. Serebryansky, and Vasily A. Demidov

Subjects
Pharmacology, Adult, Male, Chemistry, Health, Toxicology and Mutagenesis, General Medicine, Middle Aged, Reference Standards, Toxicology, Russia, Trace Elements, Young Adult, Reference values, Environmental chemistry, Occupational Exposure, Russian population, Humans, Female, Inductively coupled plasma mass spectrometry
Abstract

A total of 5908 occupationally non-exposed adults (4384 women and 1524 men) living in Moscow and Moscow region were involved in the current investigation. Hair Al, As, Be, Bi, Cd, Hg, Li, Ni, Pb, Sn, and Sr content was estimated by inductively-coupled plasma mass spectrometry using NexION 300D. Men are characterized by significantly higher hair Al, As, Cd, Hg, Li, and Pb content. At the same time, hair levels of Bi, Ni, Sn, and Sr were significantly higher in women. Consequently, the reference ranges were estimated for male, female, and general cohort as coverage intervals in accordance with IUPAC recommendations.

Published
2015

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