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IntroductionIntensive agriculture, despite high production, has adverse environmental effects, mainly due to the use of pesticides and chemical fertilizers. Therefore, we need alternative agricultural systems that are more economically and environmentally sustainable to produce crops. One of the sustainable methods in the production of agricultural products is intercropping. Intercropping of two or more species in a plot of land can increase biodiversity and resource utilization as agricultural perspective, which in turn can lead to increased yield stability. Intercropping uses resources more efficiently than monoculture, preventing the growth and spread of weeds by shading and suffocating weeds, and in some cases with allelopathic. Intercropping of cereals and legumes is recommended for the development of sustainable food production systems, especially in planting systems based on reduced consumption of foreign inputs. The importance of these systems depends on the nitrogen stabilized by the legumes. The aim of this experiment was to study the effects of row intercropping of barley and vetch and different levels of ammonium nitrate fertilizer on weed biomass, yield components and yield of two species in Karaj climatic condition.Materials and MethodsThis experiment was performed as a factorial split plot based on randomized complete block design in 2019-2020 cropping year in the research farm of the Agriculture and Natural Resources, University of Tehran. Main plots included three levels of ammonium nitrate fertilizer (0, 35 and 70 kg.ha-1) and sub-plots include different ratios of barley and vetch (100% barley, 80% barley: 20% vetch, 80% barley: 45% vetch, 80% barley: 70% vetch, 100% vetch, 80% vetch: 20% barley, 80% vetch: 45% barley, 80% vetch: 70% barley) weeding and non-weeding were in three replications. Plant density in sole barley and vetch were 250 plants per square meter. The method of cultivation in this study was additive intercropping. Seeds were sown on November 6th. The first stage of fertilization was done simultaneously with planting and one third was added to each plot and the second and third stages of fertilization were performed in two stages of stem emergence and spike emergence, respectively from ammonium nitrate fertilizer source. The final harvest was done on July 28th. Data were analyzed using SAS 9.1 software. The least significant difference test (P≤0.05) was used to compare the means.Results and DiscussionThe highest barley grain yield (432.44 g) was related to sole barley, 70 kg ammonium nitrate and weed control, which was not significantly different with 80% B: 45%V, 70 kg ammonium nitrate and weed control. Also, the highest yield of vetch grain (161.47 g) was obtained in sole vetch, application of 70 kg ammonium nitrate and weed control treatment, which was not significantly different with 80%V: 20%B intercropping, application of 70 kg ammonium nitrate and weed control treatment. Weeds in this experiment include: Wild oats (Avena fatua), ryegrass (Lolium temulentum), Bromus (Bromus tectorum), Fox tail (Alopecurus myosuroides), Wild mustard (Sinapis arvensis), Creeping Thistle (Cirsium arvense), London rocket (Sisymbrium irio), Cockspur grass (Echinochloa crus-galli) and Cornflower (Centaurea cyanus). The highest dry weight of weed (231.62 g) was observed in sole vetch, application of 70 kg.ha-1 ammonium nitrate fertilizer treatment. The highest land equivalent ratio LER (1.68) is related to 80% V: 70%B, non-application of ammonium nitrate fertilizer in weed control condition. Intercropping was successful in controlling weeds and using resources, thereby increasing the yield of plants in the experiment.ConclusionThe results obtained from the experiment showed that all different systems of barley and vetch intercropping had land equivalent ratio higher than one, which indicates the superiority of intercropping over pure crops in the land use and crop production. Intercropping treatments were also able to control weeds. Intercropping with high ability to suppress weeds were able to use more resources. On the other hand, vetch biologically stabilized nitrogen was able to reduce the need for fertilizer in plants.

The main challenge of the twenty-first century is to find a balance between environmental sustainability and crop productivity in a world with a rapidly growing population. Soil health is the backbone of a resilient environment and stable food production systems. In recent years, the use of biochar to bind nutrients, sorption of pollutants, and increase crop productivity has gained popularity. This article reviews key recent studies on the environmental impacts of biochar and the benefits of its unique physicochemical features in paddy soils. This review provides critical information on the role of biochar properties on environmental pollutants, carbon and nitrogen cycling, plant growth regulation, and microbial activities. Biochar improves the soil properties of paddy soils through increasing microbial activities and nutrient availability, accelerating carbon and nitrogen cycle, and reducing the availability of heavy metals and micropollutants. For example, a study showed that the application of a maximum of 40 t ha -1 of biochar from rice husks prior to cultivation (at high temperature and slow pyrolysis) increases nutrient utilization and rice grain yield by 40%. Biochar can be used to minimize the use of chemical fertilizers to ensure sustainable food production., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.)

CXCR4 is a member of CXC-type and G protein-coupled receptors that can conduce many biological processes, including hemostasis, migration, and adhesion of different types of immune cells. Also, the contribution of CXCR4 in metastasis cascade and development of various malignancies has been addressed in previous reports. This meta-analysis was performed to explore whether the CXCR4 expression affects prognosis and clinicopathologic features in melanoma cancer. Our study involved 656 melanoma patients from 13 reports by detailed literature search from PubMed, Embase, Web of Science, and Google Scholar up to April 2021. To evaluate the association between CXCR4 expression and clinicopathological features of melanoma, we calculated odds ratios (ORs) with its 95% confidence intervals (CIs). We indicated that the CXCR4 overexpression was obviously correlated with ulceration (OR = 0.56, 95% CI: 0.38 to 0.74; I 2  = 0.0%, P = 0.999), tumor thickness (OR = 0.56, 95% CI: 0.38 to 0.74; I 2  = 0.0%, P = 0.999) and lymph node metastasis (OR = 8.54, 95% CI: 1.04 to 16.04; I 2  = 98.9, P < 0.0001). In conclusion, our results reveal that CXCR4 is involved in enhancing the progression and metastasis of melanoma, and further clinical studies are necessary to investigate the role of CXCR4 as a diagnostic and therapeutic biomarker through the progress of melanoma cancer., (Copyright © 2021 Elsevier Ltd. All rights reserved.)

Objectives: Despite extensive caffeine use in preterm infants, the pharmacokinetics (PKs) data are limited because of the studies are complicated to do in these patients. This research was investigated the PK profile of two various dosages of caffeine in premature neonates., Materials and Methods: The PK values of caffeine in premature neonates with Apnea were predicted by using all of computer-based simulation (Simcyp ® ), population-based PK, and modeling (P-Pharm ® ). We assayed the plasma levels of caffeine in two groups. The information was analyzed utilizing nonlinear mixed-effects modeling approach. The PK parameters were assessed simulating virtual clinical considers with subjects got 20 mg. kg -1 of caffeine in both groups, which was followed by a 5 mg. kg -1 once daily in Group 1 or 2.5 mg. kg -1 twice daily in Group 2. All statistical analysis was executed utilizing SSPS issue 19 and a P value of 0.05 was chosen significance., Results: In the present study, the means CL, volume of distribution, and T1/2 of caffeine in preterm infants were 0.0476 L. h -1 , 1.1081 L, 16.2284 h, respectively. Whereas our simulated means by Simcyp were 0.090 L. h -1 , 1.841 L, and 14.653 h in Group 1 and 16.223 h in Group 2, respectively., Conclusions: There was overall good agreement between predicted and measured PK values in our study. This study provides an initial demonstration of Simcyp simulation advantage on anticipating of PK parameters., Competing Interests: None