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245 results on '"FU XueYan"'

1. DYNAMIC CHARACTERISTICS OF ROTOR-BEARING SYSTEM AND EVOLUTION OF BEARING WEAR (MT)

Author

WEI Lai, HOU XiangLin, ZHANG Yu, and FU XueYan

Subjects
Rotor-bearing system, Angular contact ball bearing, Bearing wear, Bearing preload, Dynamic characteristics, Mechanical engineering and machinery, TJ1-1570, Materials of engineering and construction. Mechanics of materials, TA401-492
Abstract

Taking the rotor system supported by angular contact ball bearing as the research object, the dynamic model of rotor bearing system is established by using Lagrange equation. Based on the Archard wear model, the calculation model of wear depth of bearing raceways considering lubrication effects is presented. The wear depth is introduced into the system dynamics model as the bearing clearance. The dynamic characteristics of rotor-bearing system and the evolution of bearing wear are carefully analyzed taking into account the rotor speed, bearing preload and disc position. The results show that the influence of bearing wear on dynamic characteristics of rotor-bearing system is closely related to rotor speed and bearing preload. Changing disc position does not lead to the significant variation of dynamic characteristics of rotor-bearing system with wear depth of bearing raceways. The rotor speed significantly affects the bearing wear, the bearing preload has very limited effect on bearing wear, and the variation of the disc position results in the weak difference of wear depth of bearings.

Published
2022
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2. BEARING WEAR ANALYSIS IN MULTI-BEARING SPINDLE SYSTEM

Author

ZHANG Yu, FU XueYan, LI Shuang, and LI SongHua

Subjects
Spindle system, Angular contact ball bearings, Wear coefficient, Wear depth, Angular misalignment, Mechanical engineering and machinery, TJ1-1570, Materials of engineering and construction. Mechanics of materials, TA401-492
Abstract

In order to clarify the effects of different working condition parameters and quantify their influence degree on bearing wear in the spindle system, the bearing wear in the spindle system supported by multi-bearing was carried out. Firstly, the calculation method of wear coefficient considering the lubrication state is introduced, and the wear depth model of the angular contact ball bearing is deduced. Second, the wear depth of the inner and outer raceways of the bearing is calculated based on the motion parameters and contact parameters of the bearing rolling elements obtained from the system model. The influences of spindle speed, bearing angular misalignment caused by mounting error, external loads and bearing surface roughness on bearing wear are discussed. The results show that the spindle speed has a significant impact on bearing wear, and the change of spindle speed leads to a great difference of bearing wear law. Without bearing angular misalignment, the sum of the wear depth of the inner and outer raceways of each bearing in the spindle system is the smallest. The change of external loads has little effect on bearing wear, but the increase in surface roughness can significantly increase the wear depth of the bearing.

Published
2021
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5. Vitamin K supplementation does not prevent bone loss in ovariectomized Norway rats

Author

Fu Xueyan, Moreines Judith, and Booth Sarah L

Subjects
Bone, Menaquinones, Phylloquinone, Vitamin K, Nutrition. Foods and food supply, TX341-641, Nutritional diseases. Deficiency diseases, RC620-627
Abstract

Abstract Background Despite plausible biological mechanisms, the differential abilities of phylloquinone (PK) and menaquinones (MKn) to prevent bone loss remain controversial. The objective of the current study was to compare the effects of PK, menaquinone-4 (MK-4) and menaquinone-7 (MK-7) on the rate of bone loss in ovariectomized (OVX) Norway rats. A secondary aim was to compare the effects of vitamin K with those of bisphosphonates (BP) on bone loss. Methods Rats (n = 96) were randomized to 6 dosing groups [n = 16/group; Sham; OVX; OVX + BP (100 μg/kg/100 μg/mL saline sc); OVX + PK; OVX + MK-4; and OVX + MK-7] for 6 wk. Equimolar daily doses of 107 mg PK/kg, 147 mg MK-4/kg, and 201 mg MK-7/kg diet were provided. Results BP significantly increased bone strength and bone mineral density (BMD) vs. OVX (P < 0.05). However, PK, MK-4 or MK-7 did not change bone strength or BMD compared to the OVX group. Whereas supplementation of PK, MK-4 and MK-7 increased serum and tibia concentrations of each respective form, PK concentrations were consistently higher despite equimolar intakes. Conclusion PK, MK-4, and MK-7 do not appear to prevent bone loss in OVX rats when administered concurrent with adequate intake of other nutrients.

Published
2012
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44. Pulsatilla chinensis (Bge.) Regel: A Systematic Review on Anticancer of Its Pharmacological Properties, Clinical Researches and Pharmacokinetic Studies

Author

Li, Hang, Wang, Lilan, Zhang, Xiaojing, Xia, Wenxin, Zhou, Xirong, Sui, Hong, and Fu, Xueyan

Subjects
Cancer Research, Oncology
Abstract

Pulsatilla chinensis (Bge.) Regel (PC) is one of the most commonly used Chinese medicines and has a history of thousands of years. This article reviews the research results of anti-cancer activity and its mechanism of action obtained from experimental, clinical, pharmacokinetic and bioinformatic studies in recent years. A large number of studies have shown that PC exerts had anti-cancer effects on different types of tumor cells by inhibiting cell proliferation, inducing apoptosis, inhibiting cell cycle and energy metabolism, inducing autophagy, and inhibiting angiogenesis. The literature has shown that PC can trigger the expression of autophagy-related molecules, activate the mitochondrial apoptotic pathway, inhibit the phosphorylation of PI3K downstream factors, down-regulate the expression of glycolysis-related proteins, and regulate a series of cancer-related signal pathways and proteins. The molecular mechanisms involved in PC include signal pathways such as Notch, PI3K/AKT/m TOR, AKT/mTOR, and MEK/ERK. The article also discusses the derivatives of the active ingredients in PC, which greatly improved the anti-cancer effect. In conclusion, this review provides a comprehensive overview of the biological effects and mechanisms of PC against cancer. The analysis of the literature shows that PC can be used as a potential drug candidate for the treatment of cancer.

Published
2022
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45. Helicobacter pylori antibiotic eradication coupled with a chemically defined diet in INS-GAS mice triggers dysbiosis and vitamin K deficiency resulting in gastric hemorrhage

Author

Quinn, Lisa, Sheh, Alexander, Ellis, Jessie L, Smith, Donald E, Booth, Sarah L, Fu, Xueyan, Muthupalani, Sureshkumar, Ge, Zhongming, Puglisi, Dylan A, Wang, Timothy C, Gonda, Tamas A, Holcombe, Hilda, Fox, James G, Quinn, Lisa, Sheh, Alexander, Ellis, Jessie L, Smith, Donald E, Booth, Sarah L, Fu, Xueyan, Muthupalani, Sureshkumar, Ge, Zhongming, Puglisi, Dylan A, Wang, Timothy C, Gonda, Tamas A, Holcombe, Hilda, and Fox, James G

Abstract

© 2020, © 2020 Taylor & Francis Group, LLC. Infection with Helicobacter pylori causes chronic inflammation and is a risk factor for gastric cancer. Antibiotic treatment or increased dietary folate prevents gastric carcinogenesis in male INS-GAS mice. To determine potential synergistic effects, H. pylori-infected male INS-GAS mice were fed an amino acid defined (AAD) diet with increased folate and were treated with antibiotics after 18 weeks of H. pylori infection. Antibiotic therapy decreased gastric pathology, but dietary folate had no effect. However, the combination of antibiotics and the AAD diet induced anemia, gastric hemorrhage, and mortality. Clinical presentation suggested hypovitaminosis K potentially caused by dietary deficiency and dysbiosis. Based on current dietary guidelines, the AAD diet was deficient in vitamin K. Phylloquinone administered subcutaneously and via a reformulated diet led to clinical improvement with no subsequent mortalities and increased hepatic vitamin K levels. We characterized the microbiome and menaquinone profiles of antibiotic-treated and antibiotic-free mice. Antibiotic treatment decreased the abundance of menaquinone producers within orders Bacteroidales and Verrucomicrobiales. PICRUSt predicted decreases in canonical menaquinone biosynthesis genes, menA and menD. Reduction of menA from Akkermansia muciniphila, Bacteroides uniformis, and Muribaculum intestinale were confirmed in antibiotic-treated mice. The fecal menaquinone profile of antibiotic-treated mice had reduced MK5 and MK6 and increased MK7 and MK11 compared to antibiotic-free mice. Loss of menaquinone-producing microbes due to antibiotics altered the enteric production of vitamin K. This study highlights the role of diet and the microbiome in maintaining vitamin K homeostasis.

Published
2022

50. Inhibit progression of coronary artery calcification with vitamin K in hemodialysis patients (the iPACK-HD study): a randomized, placebo-controlled multi-center, pilot trial

Author

Holden, Rachel M, primary, Booth, Sarah L, additional, Zimmerman, Deborah, additional, Moist, Louise, additional, Norman, Patrick A, additional, Day, Andrew G, additional, Menard, Alex, additional, Fu, Xueyan, additional, Shea, M Kyla, additional, Babiolakis, Corinne S, additional, Nolan, Robert, additional, Turner, Mandy E, additional, Ward, Emilie, additional, Kaufmann, Martin, additional, Adams, Michael A, additional, and Heyland, Daren K, additional

Published
2022
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