1. Direct oral anticoagulants in patients with nonvalvular atrial fibrillation and extreme body weight
- Author
-
Alberto Cappelletti, Margonato Alberto, Giulio Leo, Patrizio Mazzone, Matteo Montorfano, Michele De Bonis, Ottavio Alfieri, Fabiana Blunda, Paolo Della Bella, Paolo Mattiello, Michela Cera, INSigHT registry investigators, Massimo Filippi, Claudia Rubino, Francesco Melillo, Moreno Tresoldi, Alessandro Castiglioni, Cosmo Godino, Anna Salerno, Anita Russi, Francesca Bodega, Alberto Zangrillo, Bodega, F., Russi, A., Melillo, F., Blunda, F., Rubino, C., Leo, G., Cappelletti, A., Mazzone, P., Mattiello, P., Della Bella, P., Castiglioni, A., Alfieri, O., De Bonis, M., Montorfano, M., Tresoldi, M., Filippi, M., Salerno, A., Cera, M., Zangrillo, A., Alberto, M., and Godino, C.
- Subjects
Male ,medicine.medical_specialty ,Clinical Biochemistry ,Administration, Oral ,direct oral anticoagulant ,Overweight ,Biochemistry ,Dabigatran ,chemistry.chemical_compound ,body weight ,Edoxaban ,Internal medicine ,Thromboembolism ,Atrial Fibrillation ,Medicine ,Humans ,Aged ,Retrospective Studies ,Aged, 80 and over ,Rivaroxaban ,business.industry ,Body Weight ,nonvalvular atrial fibrillation ,Anticoagulants ,Atrial fibrillation ,General Medicine ,Middle Aged ,medicine.disease ,Thrombosis ,chemistry ,Apixaban ,Female ,medicine.symptom ,Underweight ,business ,medicine.drug - Abstract
Background: Limited clinical data exist describing the use of direct oral anticoagulants (DOACs) in patient with extreme body weight. Thus, the International Society of Thrombosis and Haemostasis (ISTH) recommends avoiding DOACs in patients with weight >120Kg, and on the contrary, no restrictions exist for underweight patients. Objective: To evaluate the effects of extreme body weight on DOAC activity and to compare the clinical outcomes of patients with an extreme body weight versus patients with a normal weight (61-119Kg) treated with DOACs. Methods: Single tertiary care Italian centre multidisciplinary registry including nonvalvular atrial fibrillation (NVAF) patients treated with DOACs. Based on weight, three subcohorts were defined: (i) underweight patients (≤60Kg); (ii) patients with a normal weight (61-119Kg, as control group); and (iii) overweight patients (≥120Kg). Primary efficacy endpoint was 2-year rate of thromboembolic events. Primary safety endpoint was 2-year rate of major bleeding. Event-free survival curves among groups were compared using Cox-Mantel test. Results: 812 NVAF patients were included, 108 patients weighed ≤60Kg (13%, underweight), 688 weighed between 61 and 119Kg (85%, normal weight), and 16 weighed ≥120Kg (2%, overweight). In particular, among underweight patients, dabigatran was prescribed in 26% patients, apixaban in 27%, rivaroxaban in 28% and edoxaban in 22% ones. Instead, among overweight patients, 44% were treated with dabigatran, 25% with apixaban, 25% with rivaroxaban and 4% with edoxaban. Underweight patients were older, more frequently women, with lower creatinine clearance and a history of previous strokes, resulting in higher CHA2DS2-VASc score than in both remaining groups. Up to 2years, no statistically significant difference was observed between the three groups of weight for thromboembolic events (P=.765) and for overall bleeding (P=.125), but a trend towards decreased overall bleeding rates was noticed as weight increased (24.1% vs 16.7% vs 12.5%, respectively). Conclusion: In this tertiary care centre registry, 15% of patients treated with DOACs presented an extreme weight. Compared to patients with a normal weight, no significant rates of thromboembolic events were observed for underweight or overweight patients. A trend towards decreased overall bleeding frequency as weight increased was highlighted up to 2years. The present results should be considered as preliminary and hypothesis generating.
- Published
- 2021