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Your search keyword '"Filippelli E."' showing total 3 results
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3 results on '"Filippelli E."'

1. The Italian McGill Quality of Life Questionnaire-Revised (MQoL-R): Psychometrics in Neurological and Neoplastic Populations

Author

Aiello, E, Pain, D, Radici, A, Filippelli, E, Ruvolo, S, Madonia, F, Caimi, A, Sguazzin, C, Aiello E. N., Pain D., Radici A., Filippelli E., Ruvolo S., Madonia F., Caimi A., Sguazzin C., Aiello, E, Pain, D, Radici, A, Filippelli, E, Ruvolo, S, Madonia, F, Caimi, A, Sguazzin, C, Aiello E. N., Pain D., Radici A., Filippelli E., Ruvolo S., Madonia F., Caimi A., and Sguazzin C.

Published
2022

2. Exosome-associated miRNA profile as a prognostic tool for therapy response monitoring in multiple sclerosis patients

Author

Manna I 1, Iaccino E 2, Dattilo V 2, Barone S 3, Vecchio E 2, Mimmi S 2, Filippelli E 3, Demonte G 3, Polidoro S 3, Granata A 3, Scannapieco S 3, Quinto I 2, Valentino P 3, and Quattrone A 1

Subjects
0301 basic medicine, Oncology, Adult, Male, medicine.medical_specialty, Multiple Sclerosis, biomarkers, exosomes, response to drugs, Down-Regulation, Disease, Exosomes, Biochemistry, Exosome, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, microRNA, Genetics, Biomarkers, Tumor, Medicine, Humans, Molecular Biology, business.industry, Multiple sclerosis, Neurodegeneration, Interferon-beta, medicine.disease, Prognosis, Microvesicles, Up-Regulation, MicroRNAs, 030104 developmental biology, Real-time polymerase chain reaction, Biomarker (medicine), Female, business, 030217 neurology & neurosurgery, Biotechnology
Abstract

Multiple sclerosis (MS) is an autoimmune pathology leading to neurodegeneration. Because of the complexity and heterogenic etiology of this disease, diagnosis and treatment for individual patients are challenging. Exosome-associated microRNAs (miRNAs) have recently emerged as a new class of diagnostic biomarkers involved in both autoimmune and neurologic disorders. Interesting new evidence has emerged showing that circulating miRNAs are dysregulated in MS body fluids, including serum, plasma, and cerebrospinal fluid. We hypothesized that exosome-associated miRNAs could present a readily accessible blood-based assay for MS disease. We detected expression of miRNAs by quantitative PCR on a small cohort of MS patients. We analyzed circulating exosome-associated miRNAs of MS patients before and after therapy and found that 14 exosome-associated miRNAs were significantly down-regulated, while 2 exosome-associated miRNAs were significantly up-regulated in IFN-beta-treated relapsing-remitting MS patients with response to therapy compared to those without response. We identified a serum miRNA panel that could be used to monitor the response to IFN-beta therapy. Overall, these data suggest that circulating exosome-associated miRNA profiling could represent an easily detectable biomarker of disease and treatment response.-Manna, I., Iaccino, E., Dattilo, V., Barone, S., Vecchio, E., Mimmi, S., Filippelli, E., Demonte, G., Polidoro, S., Granata, A., Scannapieco, S., Quinto, I., Valentino, P., Quattrone, A. Exosome-associated miRNA profile as a prognostic tool for therapy response monitoring in multiple sclerosis patients.

Published
2018
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3. The relationship between regional microstructural abnormalities of the corpus callosum and physical and cognitive disability in relapsing-remitting multiple sclerosis.

Author

Caligiuri ME, Barone S, Cherubini A, Augimeri A, Chiriaco C, Trotta M, Granata A, Filippelli E, Perrotta P, Valentino P, and Quattrone A

Subjects
Adult, Anisotropy, Cognition Disorders etiology, Diffusion Tensor Imaging, Female, Humans, Image Processing, Computer-Assisted, Male, Middle Aged, Multiple Sclerosis, Relapsing-Remitting complications, Neuropsychological Tests, Young Adult, Cognition Disorders pathology, Corpus Callosum pathology, Multiple Sclerosis, Relapsing-Remitting pathology
Abstract

Significant corpus callosum (CC) involvement has been found in relapsing-remitting multiple sclerosis (RRMS), even if conventional magnetic resonance imaging measures have shown poor correlation with clinical disability measures. In this work, we tested the potential of multimodal imaging of the entire CC to explain physical and cognitive disability in 47 patients with RRMS. Values of thickness, fractional anisotropy (FA) and mean diffusivity (MD) were extracted from 50 regions of interest (ROIs) sampled along the bundle. The relationships between clinical, neuropsychological and imaging variables were assessed by using Spearman's correlation. Multiple linear regression analysis was employed in order to identify the relative importance of imaging metrics in modeling different clinical variables. Regional fiber composition of the CC differentially explained the response variables (Expanded Disability Status Scale [EDSS], cognitive impairment). Increases in EDSS were explained by reductions in CC thickness and MD. Cognitive impairment was mainly explained by FA reductions in the genu and splenium. Regional CC imaging properties differentially explained disability within RRMS patients revealing strong, distinct patterns of correlation with clinical and cognitive status of patients affected by this specific clinical phenotype.

Published
2014
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