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1. Phase I Study of Acalabrutinib Plus Danvatirsen (AZD9150) in Relapsed/Refractory Diffuse Large B-Cell Lymphoma Including Circulating Tumor DNA Biomarker Assessment.

Author

Nuttall, Barrett, Acar, Melih, Burke, Kathleen, White, Rafael, Udriste, Maria, Sharma, Shringi, Dougherty, Brian, Stetson, Daniel, Jenkins, David, Mortlock, Andrew, Forcina, Alessandra, Munugalavadla, Veerendra, Flinn, Ian, Roschewski, Mark, Patel, Manish, Reagan, Patrick, Saba, Nakhle, Collins, Graham, Arkenau, Hendrik-Tobias, and De Vos, Sven

Subjects
Humans, Circulating Tumor DNA, Neoplasm Recurrence, Local, Lymphoma, Non-Hodgkin, Lymphoma, Large B-Cell, Diffuse, Antineoplastic Combined Chemotherapy Protocols, Biomarkers
Abstract

PURPOSE: Novel targeted and immunotherapies have improved outcomes in relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL), but toxicities limit widespread use. The selective Bruton tyrosine kinase (BTK) inhibitor acalabrutinib has activity in patients with R/R DLBCL but durable responses are uncommon. STAT3 inhibition has demonstrated clinical activity in DLBCL. PATIENTS AND METHODS: Final results of the phase I study of acalabrutinib plus STAT3 inhibitor (danvatirsen; AZD9150) in patients with R/R DLBCL are reported. Danvatirsen 200 mg intravenous infusion [Days 1, 3, 5 (Cycle 1); weekly infusions starting Day 8, Cycle 1] was administered in combination with oral acalabrutinib 100 mg twice daily until progressive disease (PD) or unacceptable toxicity. Primary endpoints were safety and tolerability. Secondary endpoints included efficacy, pharmacokinetics, and immunogenicity. RESULTS: Seventeen patients received combination treatment. One dose-limiting toxicity (Grade 3 liver transaminase) occurred in 1 patient. The most common reason for treatment discontinuation was PD (65%). In evaluable patients (n = 17), objective response rate was 24%; median duration of response was 1.9 months. All responders with available DLBCL cell-of-origin data were either activated B-cell or nongerminal center B-cell like subtype. Genetic subtype did not correlate with response. Baseline and longitudinal plasma cell-free DNA (cfDNA) concentrations were mostly higher in nonresponding patients. cfDNA changes were generally concordant with imaging. Pretreatment circulating B-cell levels were higher in responders versus nonresponders. CONCLUSIONS: Targeting both STAT3 and BTK in combination is safe and tolerable but efficacy is limited in R/R DLBCL. Results support evaluation of circulating tumor DNA as a biomarker for clinical response.

Published
2023

3. Nanosphere’s Verigene® Blood Culture Assay to Detect Multidrug-Resistant Gram-Negative Bacterial Outbreak: A Prospective Study on 79 Hematological Patients in a Country with High Prevalence of Antimicrobial Resistance

Author

Greco, Raffaella, Barbanti, Maria Chiara, Mancini, Nicasio, Infurnari, Laura, Pasciuta, Renée, Forcina, Alessandra, Oltolini, Chiara, Casirati, Gabriele, Mannina, Daniele, Giglio, Fabio, Messina, Carlo, Morelli, Mara, Lorentino, Francesca, Mastaglio, Sara, Perini, Tommaso, Vago, Luca, Scarpellini, Paolo, Carrabba, Matteo Giovanni, Stanghellini, Maria Teresa Lupo, Marktel, Sarah, Assanelli, Andrea, Bernardi, Massimo, Corti, Consuelo, Peccatori, Jacopo, Clementi, Massimo, and Ciceri, Fabio

Published
2019
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5. P1098: A PHASE II, OPEN-LABEL, MULTICENTER STUDY OF CAPIVASERTIB, A POTENT, ORAL PAN-AKT INHIBITOR, IN PATIENTS WITH RELAPSED OR REFRACTORY B-CELL NON-HODGKIN LYMPHOMA (CAPITAL)

Author

Hodson, Daniel, primary, Shouse, Geoffrey, additional, Shin, Ho-Jin, additional, Salar Silvestre, Antonio, additional, Bobillo Varela, Sabela, additional, Ribrag, Vincent, additional, Macpherson, Nicol, additional, Cordoba, Raul, additional, Seok Kim, Jin, additional, Radford, John, additional, Guidez, Stephanie, additional, Herrera, Alex F., additional, Morschhauser, Franck, additional, Johnson, Dachelle, additional, Izuzquiza, Macarena, additional, Sambamurthy, Nisha, additional, Forcina, Alessandra, additional, Gorgun, Gullu, additional, Chen, Robert, additional, Younes, Anas, additional, Wang, Michael, additional, and Seog Kim, Wong, additional

Published
2023
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6. S224: HIGH COMPLETE RESPONSE RATE WITH TNB-486, A NOVEL CD19XCD3 T-CELL ENGAGER, IN RELAPSED/REFRACTORY FOLLICULAR LYMPHOMA: INTERIM RESULTS FROM AN ONGOING PHASE 1 STUDY

Author

Jacobs, Ryan, primary, Nair, Ranjit, additional, Cho, Seok-Goo, additional, Devata, Sumana, additional, Gaballa, Sameh, additional, Yoon, Dok Hyun, additional, Stevens, Don, additional, Kim, Jin Seok, additional, Shah, Nirav N, additional, Brennan, Denise Marie, additional, Law, Jason, additional, Lesley, Robin, additional, Chen, Rob, additional, Forcina, Alessandra, additional, Buelow, Ben, additional, and Hou, Jing-Zhou, additional

Published
2023
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7. Phase I Study of Acalabrutinib Plus Danvatirsen (AZD9150) in Relapsed/Refractory Diffuse Large B-Cell Lymphoma Including Circulating Tumor DNA Biomarker Assessment

Author

Roschewski, Mark, primary, Patel, Manish R., additional, Reagan, Patrick M., additional, Saba, Nakhle S., additional, Collins, Graham P., additional, Arkenau, Hendrik-Tobias, additional, de Vos, Sven, additional, Nuttall, Barrett, additional, Acar, Melih, additional, Burke, Kathleen, additional, White, Rafael D., additional, Udriste, Maria, additional, Sharma, Shringi, additional, Dougherty, Brian, additional, Stetson, Daniel, additional, Jenkins, David, additional, Mortlock, Andrew, additional, Forcina, Alessandra, additional, Munugalavadla, Veerendra, additional, and Flinn, Ian, additional

Published
2023
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8. Human Herpesvirus 6 Infection Following Haploidentical Transplantation: Immune Recovery and Outcome

Author

Greco, Raffaella, Crucitti, Lara, Noviello, Maddalena, Racca, Sara, Mannina, Daniele, Forcina, Alessandra, Lorentino, Francesca, Valtolina, Veronica, Rolla, Serena, Dvir, Roee, Morelli, Mara, Giglio, Fabio, Barbanti, Maria Chiara, Lupo Stanghellini, Maria Teresa, Oltolini, Chiara, Vago, Luca, Scarpellini, Paolo, Assanelli, Andrea, Carrabba, Matteo G., Marktel, Sarah, Bernardi, Massimo, Corti, Consuelo, Clementi, Massimo, Peccatori, Jacopo, Bonini, Chiara, and Ciceri, Fabio

Published
2016
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9. Enteric Microbiome Markers as Early Predictors of Clinical Outcome in Allogeneic Hematopoietic Stem Cell Transplant: Results of a Prospective Study in Adult Patients

Author

Mancini, Nicasio, Greco, Raffaella, Pasciuta, Renée, Barbanti, Maria Chiara, Pini, Giacomo, Morrow, Olivia Beatrice, Morelli, Mara, Vago, Luca, Clementi, Nicola, Giglio, Fabio, Lupo Stanghellini, Maria Teresa, Forcina, Alessandra, Infurnari, Laura, Marktel, Sarah, Assanelli, Andrea, Carrabba, Matteo, Bernardi, Massimo, Corti, Consuelo, Burioni, Roberto, Peccatori, Jacopo, Sormani, Maria Pia, Banfi, Giuseppe, Ciceri, Fabio, and Clementi, Massimo

Published
2017
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10. Magrolimab, Rituximab and Acalabrutinib for Relapsed/Refractory (R/R) Diffuse Large B-Cell Lymphoma (DLBCL): Results from the Phase 1 PRISM Trial

Author

de Vos, Sven, primary, Reagan, Patrick M., additional, Patel, Manish R., additional, Saba, Nakhle S., additional, Mortlock, Andrew, additional, Cerec, Virginie, additional, Munugalavadla, Veerendra, additional, Acar, Melih, additional, Nuttall, Barrett, additional, Jenkins, David, additional, White, Rafael, additional, Callahan, Megan, additional, Forcina, Alessandra, additional, Roschewski, Mark, additional, and Flinn, Ian W., additional

Published
2022
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11. Abstract CT127: Trial in progress: A phase II, open-label, multicenter study of capivasertib, a potent, oral pan-AKT inhibitor in patients with relapsed or refractory B-cell non-hodgkin lymphoma (CAPITAL)

Author

Wang, Michael, primary, Shin, Ho-Jin, additional, Herrera, Alex F., additional, Levy, Moshe, additional, Kim, Wong Seog, additional, Kim, Tae Min, additional, Kim, Jin Seok, additional, Yoon, Dok Hyun, additional, Ribrag, Vincent, additional, Canales, Miguel, additional, Radford, John, additional, El-Sharkawi, Dima, additional, Hemmer, Brandy, additional, Manwani, Richa, additional, Munugalavadla, Veerendra, additional, Chen, Robert, additional, Mortlock, Andrew, additional, Forcina, Alessandra, additional, and Morschhauser, Franck, additional

Published
2022
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13. Double Step-up Dosing (2SUD) Regimen Mitigates Severe Icans and CRS While Maintaining High Efficacy in Subjects with Relapsed/Refractory (R/R) B-Cell Non-Hodgkin Lymphoma (NHL) Treated with AZD0486, a Novel CD19xCD3 T-Cell Engager (TCE): Updated Safety and Efficacy Data from the Ongoing First-in-Human (FIH) Phase 1 Trial

Author

Gaballa, Sameh, Nair, Ranjit, Jacobs, Ryan W, Devata, Sumana, Cho, Seok-Goo, Stevens, Don A., Yoon, Dok Hyun, Shah, Nirav N., Brennan, Denise, Law, Jason, Chen, Robert, Sermer, David, Lesley, Robin, Buelow, Ben, Forcina, Alessandra, and Hou, Jing-Zhou

Published
2023
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14. Efficacy and Safety of Tisagenlecleucel in Adult Patients with Relapsed/Refractory Follicular Lymphoma: Interim Analysis of the Phase 2 Elara Trial

Author

Fowler, Nathan H, Dickinson, Michael, Dreyling, Martin, Martinez-Lopez, Joaquin, Kolstad, Arne, Butler, Jason P, Ghosh, Monalisa, Popplewell, Leslie L., Chavez, Julio C., Bachy, Emmanuel, Kato, Koji, Harigae, Hideo, Kersten, Marie José, Andreadis, Charalambos, Riedell, Peter A., Ho, P. Joy, Pérez-Simón, Jose Antonio, Nagle, Sarah J., Nastoupil, Loretta J., von Tresckow, Bastian, Ferreri, Andres JM, Teshima, Takanori, Patten, Piers, McGuirk, Joseph P., Petzer, Andreas, Offner, Fritz C., Viardot, Andreas, Zinzani, Pier Luigi, Malladi, Ram, Bubuteishvili Pacaud, Lida, Forcina, Alessandra, Zia, Aiesha, Schuster, Stephen J., and Thieblemont, Catherine

Published
2020
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15. Systematic Literature Review of the Clinical Efficacy, Safety, and Patient-Reported Outcomes of Treatments in Patients with Relapsed or Refractory Follicular Lymphoma after Two Prior Therapies

Author

Ma, Qiufei, primary, Kaur, Simarjeet, additional, Zhao, Angela, additional, Zhang, Jie, additional, Ramos, Roberto Javier, additional, Kumar, Dinesh, additional, John, Lokho, additional, Bubuteishvili Pacaud, Lida, additional, and Forcina, Alessandra, additional

Published
2020
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16. Abstract CT162: The phase 1b PORTIA study: Safety and efficacy of tisagenlecleucel plus pembrolizumab in patients with relapsed/refractory diffuse large B-cell lymphoma (r/r DLBCL)

Author

Jaeger, Ulrich, primary, Worel, Nina, additional, McGuirk, Joseph P., additional, Riedell, Peter A., additional, Fleury, Isabelle, additional, Borchmann, Peter, additional, Newsome, Simon, additional, Abdelhady, Ahmed M., additional, Forcina, Alessandra, additional, Pacaud, Lida Bubuteishvili, additional, and Waller, Edmund K., additional

Published
2020
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17. Incidence, Risk Factors and Outcome of Pre-engraftment Gram-Negative Bacteremia After Allogeneic and Autologous Hematopoietic Stem Cell Transplantation: An Italian Prospective Multicenter Survey

Author

Girmenia, Corrado, Bertaina, Alice, Piciocchi, Alfonso, Perruccio, Katia, Algarotti, Alessandra, Busca, Alessandro, Cattaneo, Chiara, Raiola, Anna Maria, Guidi, Stefano, Iori, Anna Paola, Candoni, Anna, Irrera, Giuseppe, Milone, Giuseppe, Marcacci, Giampaolo, Scimè, Rosanna, Musso, Maurizio, Cudillo, Laura, Sica, Simona, Castagna, Luca, Corradini, Paolo, Marchesi, Francesco, Pastore, Domenico, Alessandrino, Emilio Paolo, Annaloro, Claudio, Ciceri, Fabio, Santarone, Stella, Nassi, Luca, Farina, Claudio, Viscoli, Claudio, Rossolini, Gian Maria, Bonifazi, Francesca, Rambaldi, Alessandro, Capria, Saveria, Bertaina, A., Mastronuzzi, Angela, Pagliara, Daria, Bernaschi, Paola, Amico, Lucia, Carotti, Alessandra, Mencacci, Antonella, Busca, A., Bruno, Benedetto, Costa, Cristina, Passi, Angela, Ravizzola, Giuseppe, Angelucci, Emanuele, Marchese, Anna, Pecile, Patrizia, Candoni, A., Ventura, Giovanna, Fanin, Renato, Scarparo, Claudio, Barbaro, Angelo, Milone, G., Leotta, Salvatore, Marchese, Anna Elisa, Marcacci, G., Becchimanzi, Cristina, Donnarumma, Daniela, Tringali, Stefania, Baldi, Maria Teresa, Scalone, Renato, Cudillo, L., Picardi, Alessandra, Arcese, William, Fontana, Carla, Sica, S., Giammarco, Sabrina, Spanu, Teresa, Castagna, L., Crocchiolo, Roberto, Casari, Erminia, Mussetti, Alberto, Conte, Eutilia, Ensoli, Fabrizio, Miragliotta, Giuseppe, Marone, Piero, Arghittu, Milena, Greco, Raffaella, Forcina, Alessandra, Chichero, Paola, Santarone, S., Di Bartolomeo, Paolo, Fazii, Paolo, Kroumova, Vesselina, Decembrino, Nunzia, Zecca, Marco, Pisapia, Giovanni, Palazzo, Giulia, Lanino, Edoardo, Faraci, Maura, Castagnola, Elio, Bandettini, Roberto, Pastano, Rocco, Sammassimo, Simona, Passerini, Rita, Stefani, Piero Maria, Gherlinzoni, Filippo, Rigoli, Roberto, Prezioso, Lucia, Cambò, Benedetta, Calderaro, Adriana, Carella, Angelo Michele, Cascavilla, Nicola, Labonia, Maria Teresa, Celeghini, Ivana, Mordini, Nicola, Piana, Federica, Vacca, Adriana, Sanna, Marco, Podda, Giovanni, Corsetti, Maria Teresa, Rocchetti, Andrea, Cilloni, Daniela, De Gobbi, Marco, Bianco, Ornella, Fagioli, Franca, Carraro, Francesca, De Intinis, Gianfranco, Severino, Alessandro, Proia, Anna, Parisi, Gabriella, Vallisa, Daniele, Confalonieri, Massimo, Russo, Domenico, Malagola, Michele, Galieni, Piero, Falcioni, Sadia, Travaglini, Valeria, Raimondi, Roberto, Borghero, Carlo, Pavan, Giacomina, Prete, Arcangelo, Belotti, Tamara, Ambretti, Simone, Imola, Manuela, Mianulli, Anna Maria, Pedna, Maria Federica, Cesaro, Simone, Lo Cascio, Giuliana, Ferrari, Antonella, Piedimonte, Monica, Santino, Iolanda, Calandrelli, Monica, Olivieri, Attilio, Orecchioni, Francesca, Mirabile, Milena, Centurioni, Riccardo, Gironacci, Luciana, Caravelli, Daniela, Gallo, Susanna, De Filippi, Marco, Cupelli, Luca, Dentamaro, Teresa, Falco, Silvana, Eugenio, Ospedale S, Marotta, Serena, Risitano, Antonio, Lula, Dora, Musto, Pellegrino, Pietrantuono, Giuseppe, Traficante, Antonio, Cerchiara, Elisabetta, Tirindelli, Maria Cristina, Dicuonzo, Giordano, Chierichini, Anna, Anaclerico, Barbara, Placanica, Paola, Girmenia, C, Bertaina, A, Piciocchi, A, Perruccio, K, Algarotti, A, Busca, A, Cattaneo, C, Raiola, Am, Guidi, S, Iori, Ap, Candoni, A, Irrera, G, Milone, G, Marcacci, G, Scimè, R, Musso, M, Cudillo, L, Sica, S, Castagna, L, Corradini, P, Marchesi, F, Pastore, D, Alessandrino, Ep, Annaloro, C, Ciceri, F, Santarone, S, Nassi, L, Farina, C, Viscoli, C, Rossolini, Gm, Bonifazi, F, Rambaldi, A, for the Gruppo Italiano Trapianto di Midollo Osseo, (GITMO), Associazione Microbiologi Clinici Italiani, (AMCLI), Girmenia, Corrado, Bertaina, Alice, Piciocchi, Alfonso, Perruccio, Katia, Algarotti, Alessandra, Busca, Alessandro, Cattaneo, Chiara, Raiola, Anna Maria, Guidi, Stefano, Iori, Anna Paola, Candoni, Anna, Irrera, Giuseppe, Milone, G., Marcacci, Giampaolo, Scimè, Rosanna, Musso, Maurizio, Cudillo, Laura, Sica, Simona, Castagna, Luca, Corradini, Paolo, Marchesi, Francesco, Pastore, Domenico, Alessandrino, Emilio Paolo, Annaloro, Claudio, Ciceri, Fabio, Santarone, Stella, Nassi, Luca, Farina, Claudio, Viscoli, Claudio, Rossolini, Gian Maria, Bonifazi, Francesca, Rambaldi, Alessandro, Capria, Saveria, Bertaina, A., Mastronuzzi, Angela, Pagliara, Daria, Bernaschi, Paola, Amico, Lucia, Carotti, Alessandra, Mencacci, Antonella, Busca, A., Bruno, Benedetto, Costa, Cristina, Passi, Angela, Ravizzola, Giuseppe, Angelucci, Emanuele, Marchese, Anna, Pecile, Patrizia, Candoni, A., Ventura, Giovanna, Fanin, Renato, Scarparo, Claudio, Barbaro, Angelo, Leotta, Salvatore, Marchese, Anna Elisa, Marcacci, G., Becchimanzi, Cristina, Donnarumma, Daniela, Tringali, Stefania, Baldi, Maria Teresa, Scalone, Renato, Cudillo, L., Picardi, Alessandra, Arcese, William, Fontana, Carla, Sica, S., Giammarco, Sabrina, Spanu, Teresa, Castagna, L., Crocchiolo, Roberto, Casari, Erminia, Mussetti, Alberto, Conte, Eutilia, Ensoli, Fabrizio, Miragliotta, Giuseppe, Marone, Piero, Arghittu, Milena, Greco, Raffaella, Forcina, Alessandra, Chichero, Paola, Santarone, S., Di Bartolomeo, Paolo, Fazii, Paolo, Kroumova, Vesselina, Decembrino, Nunzia, Zecca, Marco, Pisapia, Giovanni, Palazzo, Giulia, Lanino, Edoardo, Faraci, Maura, Castagnola, Elio, Bandettini, Roberto, Pastano, Rocco, Sammassimo, Simona, Passerini, Rita, Stefani, Piero Maria, Gherlinzoni, Filippo, Rigoli, Roberto, Prezioso, Lucia, Cambò, Benedetta, Calderaro, Adriana, Carella, Angelo Michele, Cascavilla, Nicola, Labonia, Maria Teresa, Celeghini, Ivana, Mordini, Nicola, Piana, Federica, Vacca, Adriana, Sanna, Marco, Podda, Giovanni, Corsetti, Maria Teresa, Rocchetti, Andrea, Cilloni, Daniela, De Gobbi, Marco, Bianco, Ornella, Fagioli, Franca, Carraro, Francesca, De Intinis, Gianfranco, Severino, Alessandro, Proia, Anna, Parisi, Gabriella, Vallisa, Daniele, Confalonieri, Massimo, Russo, Domenico, Malagola, Michele, Galieni, Piero, Falcioni, Sadia, Travaglini, Valeria, Raimondi, Roberto, Borghero, Carlo, Pavan, Giacomina, Prete, Arcangelo, Belotti, Tamara, Ambretti, Simone, Imola, Manuela, Mianulli, Anna Maria, Pedna, Maria Federica, Cesaro, Simone, Lo Cascio, Giuliana, Ferrari, Antonella, Piedimonte, Monica, Santino, Iolanda, Calandrelli, Monica, Olivieri, Attilio, Orecchioni, Francesca, Mirabile, Milena, Centurioni, Riccardo, Gironacci, Luciana, Caravelli, Daniela, Gallo, Susanna, De Filippi, Marco, Cupelli, Luca, Dentamaro, Teresa, Falco, Silvana, Eugenio, Ospedale S, Marotta, Serena, Risitano, Antonio, Lula, Dora, Musto, Pellegrino, Pietrantuono, Giuseppe, Traficante, Antonio, Cerchiara, Elisabetta, Tirindelli, Maria Cristina, Dicuonzo, Giordano, Chierichini, Anna, Anaclerico, Barbara, and Placanica, Paola

Subjects
0301 basic medicine, Male, Transplantation Conditioning, Drug Resistance, Bacteremia, 0302 clinical medicine, epidemiology, Gram negative bacteremia, multidrug resistance, stem cell transplant, survival, Risk Factors, Drug Resistance, Multiple, Bacterial, Epidemiology, Medicine, Age Factor, Prospective Studies, Prospective cohort study, Child, Transplantation, Homologou, education.field_of_study, Incidence (epidemiology), Incidence, Bacterial, Age Factors, Hematopoietic Stem Cell Transplantation, Middle Aged, Transplantation, Autologou, surgical procedures, operative, Infectious Diseases, Italy, Child, Preschool, Female, medicine.symptom, Multiple, Autologous, Human, Homologous, Microbiology (medical), Adult, medicine.medical_specialty, Adolescent, 030106 microbiology, Population, Transplantation, Autologous, 03 medical and health sciences, Young Adult, Internal medicine, Gram-Negative Bacteria, Gram-Negative Bacterial Infection, Escherichia coli, Humans, Transplantation, Homologous, Preschool, education, Aged, Gram-Negative Bacterial Infections, Infant, Transplantation, business.industry, Risk Factor, medicine.disease, Prospective Studie, Carriage, Otitis, business, Settore MED/15 - Malattie del Sangue, 030215 immunology
Abstract

Background Gram-negative bacteremia (GNB) is a major cause of illness and death after hematopoietic stem cell transplantation (HSCT), and updated epidemiological investigation is advisable. Methods We prospectively evaluated the epidemiology of pre-engraftment GNB in 1118 allogeneic HSCTs (allo-HSCTs) and 1625 autologous HSCTs (auto-HSCTs) among 54 transplant centers during 2014 (SIGNB-GITMO-AMCLI study). Using logistic regression methods. we identified risk factors for GNB and evaluated the impact of GNB on the 4-month overall-survival after transplant. Results The cumulative incidence of pre-engraftment GNB was 17.3% in allo-HSCT and 9% in auto-HSCT. Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa were the most common isolates. By multivariate analysis, variables associated with GNB were a diagnosis of acute leukemia, a transplant from a HLA-mismatched donor and from cord blood, older age, and duration of severe neutropenia in allo-HSCT, and a diagnosis of lymphoma, older age, and no antibacterial prophylaxis in auto-HSCT. A pretransplant infection by a resistant pathogen was significantly associated with an increased risk of posttransplant infection by the same microorganism in allo-HSCT. Colonization by resistant gram-negative bacteria was significantly associated with an increased rate of infection by the same pathogen in both transplant procedures. GNB was independently associated with increased mortality at 4 months both in allo-HSCT (hazard ratio, 2.13; 95% confidence interval, 1.45–3.13; P Conclusions Pre-engraftment GNB is an independent factor associated with increased mortality rate at 4 months after auto-HSCT and allo-HSCT. Previous infectious history and colonization monitoring represent major indicators of GNB. Clinical Trials registration NCT02088840.

Published
2017

18. Portia: A Phase 1b Study Evaluating Safety and Efficacy of Tisagenlecleucel and Pembrolizumab in Patients with Relapsed/Refractory Diffuse Large B-Cell Lymphoma

Author

Jaeger, Ulrich, primary, Worel, Nina, additional, McGuirk, Joseph P., additional, Riedell, Peter A., additional, Fleury, Isabelle, additional, Borchmann, Peter, additional, Chu, Jufen, additional, Abdelhady, Ahmed M, additional, Forcina, Alessandra, additional, Bubuteishvili Pacaud, Lida, additional, and Waller, Edmund K., additional

Published
2019
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19. 78 - Efficacy and Safety of Tisagenlecleucel in Adult Patients with Relapsed/Refractory Follicular Lymphoma: Interim Analysis of the Phase 2 Elara Trial

Author

Fowler, Nathan, Dickinson, Michael, Dreyling, Martin, Martinez-Lopez, Joaquin, Kolstad, Arne, Butler, Jason, Ghosh, Monalisa, Popplewell, Leslie, Chavez, Julio C., Bachy, Emmanuel, Kato, Koji, Harigae, Hideo, Kersten, Marie José, Andreadis, Charalambos, Riedell, Peter A., Ho, P Joy, Pérez Simón, José Antonio, Nagle, Sarah, Nastoupil, Loretta J., von Tresckow, Bastian, María Ferreri, Andrés José, Teshima, Takanori, Patten, Piers EM, McGuirk, Joseph P, Petzer, Andreas, Offner, Fritz, Viardot, Andreas, Zinzani, Pierluigi, Malladi, Ram, Pacaud, Lida B., Forcina, Alessandra, Zia, Aiesha, Schuster, Stephen J., and Thieblemont, Catherine

Published
2021
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21. HHV6 Specific T-Cells Are Predictive Biomarker of Active HHV6 Infection after Allogeneic Hematopoietic Stem Cell Transplantation: Results of a Prospective Study in 213 Patients

Author

Greco, Raffaella, primary, Noviello, Maddalena, additional, Crucitti, Lara, additional, Racca, Sara, additional, Valtolina, Veronica, additional, Morelli, Mara, additional, Giglio, Fabio, additional, Mannina, Daniele, additional, Barbanti, Maria Chiara, additional, Forcina, Alessandra, additional, Pozzato, Mattia, additional, Rolla, Serena, additional, Assanelli, Andrea Angelo, additional, Carrabba, Matteo Giovanni, additional, Marktel, Sarah, additional, Bernardi, Massimo, additional, Corti, Consuelo, additional, Lupo Stanghellini, Maria Teresa, additional, Vago, Luca, additional, Peccatori, Jacopo, additional, Clementi, Massimo, additional, Ciceri, Fabio, additional, and Bonini, Chiara, additional

Published
2016
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22. Biomarkers Predicting Acute GvHD and Transplant Outcomes in 120 Consecutive Allogeneic HSCT Recipients

Author

Greco, Raffaella, primary, Lorentino, Francesca, additional, Lupo Stanghellini, Maria Teresa, additional, Cheyenne Vaccari, Linda, additional, Nitti, Rosamaria, additional, Barbanti, Maria Chiara, additional, Forcina, Alessandra, additional, Giglio, Fabio, additional, Morelli, Mara, additional, Mannina, Daniele, additional, Perini, Tommaso, additional, Mastaglio, Sara, additional, Piemontese, Simona, additional, Assanelli, Andrea Angelo, additional, Marktel, Sarah, additional, Carrabba, Matteo Giovanni, additional, Vago, Luca, additional, Corti, Consuelo, additional, Bernardi, Massimo, additional, Ciceri, Fabio, additional, and Peccatori, Jacopo, additional

Published
2016
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23. Disease Risk Index (DRI) Score Stratification and Composite End-Point GvHD-Free Relapse-Free Survival (GRFS) May Optimize Transplant Decision-Making Process in Haploidentical Stem Cell Transplantation

Author

Lupo-Stanghellini, Maria Teresa, primary, Antonarelli, Gabriele, additional, Lorentino, Francesca, additional, Sala, Elisa, additional, Morelli, Mara, additional, Greco, Raffaella, additional, Marcatti, Magda, additional, Piemontese, Simona, additional, Perini, Tommaso, additional, Assanelli, Andrea Angelo, additional, Carrabba, Matteo Giovanni, additional, Forcina, Alessandra, additional, Dalto, Serena Camilla, additional, Mastaglio, Sara, additional, Marktel, Sarah, additional, Lunghi, Francesca, additional, Guggiari, Elena, additional, Giglio, Fabio, additional, Pavesi, Francesca, additional, Vago, Luca, additional, Bernardi, Massimo, additional, Corti, Consuelo, additional, Peccatori, Jacopo, additional, and Ciceri, Fabio, additional

Published
2016
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24. Pre-Transplant Colonization By a Multidrug-Resistant Gram Negative Bacteria Has No Impact on Overall Survival and Mortality after Hematopoietic Stem Cell Transplantation: A Single-Center Experience in 362 Patients

Author

Marasco, Vincenzo, primary, Forcina, Alessandra, additional, Lorentino, Francesca, additional, Greco, Raffaella, additional, Morelli, Mara, additional, Giglio, Fabio, additional, Messina, Carlo, additional, Lupo Stanghellini, Maria Teresa, additional, Matteo, Carrabba, additional, Marcatti, Magda, additional, Bondanza, Attilio, additional, Bernardi, Massimo, additional, Peccatori, Jacopo, additional, Corti, Consuelo, additional, and Ciceri, Fabio, additional

Published
2016
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25. Infection-Related Mortality (IRM) after Allogeneic Hematopoietic Stem Cell Transplantation: Age, CMV Status, Pre-Transplant IgA and IgM Levels Predict IRM and Survival in a New Clinico-Biological Scoring System Developed in 492 Consecutive Patients

Author

Forcina, Alessandra, primary, Rancoita, Paola Maria Vittoria, additional, Marasco, Vincenzo, additional, Greco, Raffaella, additional, Lupo-Stanghellini, Maria Teresa, additional, Carrabba, Matteo Giovanni, additional, Magda, Marcatti, additional, Di Serio, Clelia, additional, Bernardi, Massimo, additional, Peccatori, Jacopo, additional, Corti, Consuelo, additional, Bondanza, Attilio, additional, and Ciceri, Fabio, additional

Published
2016
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26. Longitudinal Microbiome Profile in Allogeneic Hematopoietic Stem Cell Transplantation: Results of a Prospective Study in 100 Patients

Author

Greco, Raffaella, primary, Mancini, Nicasio, additional, Pasciuta, Renée, additional, Barbanti, Maria Chiara, additional, Morelli, Mara, additional, Vago, Luca, additional, Giglio, Fabio, additional, Lupo Stanghellini, Maria Teresa, additional, Forcina, Alessandra, additional, Infurnari, Laura, additional, Marktel, Sarah, additional, Assanelli, Andrea Angelo, additional, Carrabba, Matteo Giovanni, additional, Bernardi, Massimo, additional, Corti, Consuelo, additional, Peccatori, Jacopo, additional, Clementi, Massimo, additional, and Ciceri, Fabio, additional

Published
2016
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27. Integrating a prospective pilot trial and patient-derived xenografts to trace metabolic changes associated with acute myeloid leukemia

Author

Carrabba, Matteo G., primary, Tavel, Laurette, additional, Oliveira, Giacomo, additional, Forcina, Alessandra, additional, Quilici, Giacomo, additional, Nardelli, Francesca, additional, Tresoldi, Cristina, additional, Ambrosi, Alessandro, additional, Ciceri, Fabio, additional, Bernardi, Massimo, additional, Vago, Luca, additional, and Musco, Giovanna, additional

Published
2016
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28. Facing the Rising Tide of Multidrug Resistant Gram-Negative Pathogens in Allogeneic HSCT with Nanosphere's Verigene® System

Author

Greco, Raffaella, primary, Barbanti, Maria Chiara, additional, Mancini, Nicasio, additional, Infurnari, Laura, additional, Pasciuta, Renée, additional, Forcina, Alessandra, additional, Vago, Luca, additional, Giglio, Fabio, additional, Messina, Carlo, additional, Morelli, Mara, additional, Perini, Tommaso, additional, Girlanda, Stefania, additional, Carrabba, Matteo G, additional, Lupo Stanghellini, Maria Teresa, additional, Marktel, Sarah, additional, Assanelli, Andrea, additional, Bernardi, Massimo, additional, Corti, Consuelo, additional, Peccatori, Jacopo, additional, Clementi, Massimo, additional, and Ciceri, Fabio, additional

Published
2015
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29. Refined Disease Risk Index (DRI) and Hematopoietic Cell Transplantation Comorbidity Index (HCT-CI) Predict Survival after Haploidentical Stem Cell Transplantation: A Comparative Study with EBMT Risk Score in 220 Consecutive Patients

Author

Mara Morelli, Sarah Marktel, Massimo Bernardi, Raffaella Greco, Maria Teresa Lupo-Stanghellini, Fabio Giglio, Luca Vago, Sara Mastaglio, Carlo Messina, Forcina Alessandra, Jacopo Peccatori, Francesca Lunghi, Matteo Carrabba, Magda Marcatti, Elisa Sala, Simona Piemontese, Andrea Assanelli, Consuelo Corti, Malato Simona, Francesca Pavesi, Fabio Ciceri, Francesca Lorentino, Elena Guggiari, Lupo-Stanghellini, Mt, Sala, E, Piemontese, S, Morelli, M, Greco, R, Marcatti, M, Assanelli, A, Carrabba, Mg, Alessandra, F, Mastaglio, S, Marktel, S, Lorentino, F, Lunghi, F, Guggiari, E, Giglio, F, Simona, M, Pavesi, F, Messina, C, Vago, L, Corti, C, Bernardi, M, Peccatori, J, and Ciceri, F

Subjects
medicine.medical_specialty, Framingham Risk Score, business.industry, Immunology, Context (language use), Retrospective cohort study, Cell Biology, Hematology, Total body irradiation, Treosulfan, Biochemistry, Surgery, Transplantation, Clinical trial, surgical procedures, operative, Internal medicine, medicine, business, Risk assessment, medicine.drug
Abstract

Background Optimization of pre-transplant risk assessment is a crucial issue to improve the allo-HSCT decision making process. Actually 3 major algorithms are in use in clinical practice: the EBMT risk score, the Hematopoietic Cell Transplantation Comorbidity Index (HCT-CI) score and - more recently introduced - the refined Disease Risk Index (DRI). DRI was defined to calibrate HSCT outcome across studies and centers. It was developed as a tool to assign patients into risk groups based on disease type and status at the time of transplantation. The aim of the DRI is to provide a robust tool that can be used for prognostication, for the analysis and interpretation of retrospective data, whether conducted in single-center, multicenter, or registry settings, or within the context of the federally mandated center outcome reporting. The DRI can also be used for the stratification of patients entering prospective HCT clinical trials. DRI is not a fixed tool but instead it was conceived to be refined by the transplant community as new information becomes available. Here we are presenting the results of a retrospective study designed to evaluate the 3 aforementioned score in stratification and prognostication of transplant outcome after a haploidentical HSCT (haplo-HSCT). Patients and Methods We included 220 adult patients (pts - 138 male, 82 female) who underwent a haplo-HSCT for hematologic malignancies, between 2006 and 2014 and were reported to our Institutional database. Risk assessment score and outcome analysis included all consecutive pts receiving an haplo-HSCT as 1st allogeneic transplantation. Pts receiving haplo-HSCT as 2nd or 3rd HSCT were excluded from the present analysis. Median age was 49 years (range, 15-77). The cohort included a broad representation of diseases (138/220 acute leukemia, 30 Hodgkin lymphoma); 62 pts were in complete remission at transplant, 158 were presenting active disease. Conditioning regimens mostly rely upon the combination of treosulfan plus fludarabine (201/220) and total body irradiation (range 200 - 400 cGy) was utilized in 52 patients. GVHD prophylaxis consisted mostly of an mTor inhibitor (rapamycin) combined with mycophenolate mofetil. The majority of patients received peripheral blood stem cells from a family haploidentical donor as stem cell source, while only 4 patients received bone marrow transplant. A written consent was given by pts allowing the use of medical records for research in accordance with the Declaration of Helsinki. Results The median follow-up for survivors was 37 months (r 6-107). The overall survival (OS) at 2-y was 35% and the transplant related mortality at 100-days 23%. The 2y OS according to EBMT / HCT-CI / DRI risk score are reported in table 1.a and figure 1. The evaluation of the HCT-CI impact after DRI stratification was able to show a significant difference in outcome showing better survival for pts with low DRI score and low HCT-CI score as expected (table 1.b). Discussion Refined DRI score and HCT-CI score predict survival after haplo-HSCT. The integrated application of refined DRI and HCT-CI may improve the definition of transplant eligibility for pts candidate to allogeneic HSCT form alternative donors including family haploidentical source. Table 1a. EBMT score 0-3 % pts 4-5 %pts > 5 %pts p 51% 17 34% 51 27% 32 0.07 HCT-CI score 0-2 3-4 >/= 5 48% 59 36% 31 0% 10 0.0001 DRI score Low-Intermediate High Very-High 61% 32 27% 51 5% 17 0.0001 Table 1b. HCT-CI 0-4 HCT-CI >/=5 p DRILow-Intermediate 64% 0% 0.0001 DRIHigh-Very High 29% 0% Figure 1. Figure 1. Disclosures No relevant conflicts of interest to declare.

Published
2015

30. A novel self-lipid antigen targets human T cells against CD1c(+) leukemias

Author

Lepore, Marco, de Lalla, Claudia, Gundimeda, S Ramanjaneyulu, Gsellinger, Heiko, Consonni, Michela, Garavaglia, Claudio, Sansano, Sebastiano, Piccolo, Francesco, Scelfo, Andrea, Häussinger, Daniel, Montagna, Daniela, Locatelli, Franco, Bonini, Chiara, Bondanza, Attilio, Forcina, Alessandra, Li, Zhiyuan, Ni, Guanghui, Ciceri, Fabio, Jenö, Paul, Xia, Chengfeng, Mori, Lucia, Dellabona, Paolo, Casorati, Giulia, De Libero, Gennaro, Locatelli, Franco (ORCID:0000-0002-7976-3654), Lepore, Marco, de Lalla, Claudia, Gundimeda, S Ramanjaneyulu, Gsellinger, Heiko, Consonni, Michela, Garavaglia, Claudio, Sansano, Sebastiano, Piccolo, Francesco, Scelfo, Andrea, Häussinger, Daniel, Montagna, Daniela, Locatelli, Franco, Bonini, Chiara, Bondanza, Attilio, Forcina, Alessandra, Li, Zhiyuan, Ni, Guanghui, Ciceri, Fabio, Jenö, Paul, Xia, Chengfeng, Mori, Lucia, Dellabona, Paolo, Casorati, Giulia, De Libero, Gennaro, and Locatelli, Franco (ORCID:0000-0002-7976-3654)

Abstract

T cells that recognize self-lipids presented by CD1c are frequent in the peripheral blood of healthy individuals and kill transformed hematopoietic cells, but little is known about their antigen specificity and potential antileukemia effects. We report that CD1c self-reactive T cells recognize a novel class of self-lipids, identified as methyl-lysophosphatidic acids (mLPAs), which are accumulated in leukemia cells. Primary acute myeloid and B cell acute leukemia blasts express CD1 molecules. mLPA-specific T cells efficiently kill CD1c(+) acute leukemia cells, poorly recognize nontransformed CD1c-expressing cells, and protect immuno-deficient mice against CD1c+ human leukemia cells. The identification of immunogenic self-lipid antigens accumulated in leukemia cells and the observed leukemia control by lipid-specific T cells in vivo provide a new conceptual framework for leukemia immune surveillance and possible immunotherapy.

Published
2014

31. Human Herpes Virus 6 Infection in 54 Patients after Allogeneic Hematopoietic Stem Cell Transplantation: Clinical Manifestations and Outcome

Author

Greco, Raffaella, primary, Crucitti, Lara, additional, Racca, Sara, additional, Dvir, Roee, additional, Lorentino, Francesca, additional, Vago, Luca, additional, Forcina, Alessandra, additional, Rolla, Serena, additional, Valtolina, Veronica, additional, Noviello, Maddalena, additional, Lupo Stanghellini, Maria Teresa, additional, Giglio, Fabio, additional, Morelli, Mara, additional, Levati, Giorgia, additional, Assanelli, Andrea, additional, Carrabba, Matteo G, additional, Marktel, Sarah, additional, Bernardi, Massimo, additional, Corti, Consuelo, additional, Peccatori, Jacopo, additional, Bonini, Chiara, additional, Clementi, Massimo, additional, and Ciceri, Fabio, additional

Published
2014
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32. Graft-Versus-Host Disease after Haploidentical Stem Cell Transplantation in High Risk Haematological Diseases: A 10-Years Evaluation at San Raffaele Scientific Institute

Author

Lupo-Stanghellini, Maria Teresa, primary, Orsini, Alessia, additional, Crucitti, Lara, additional, Crocchiolo, Roberto, additional, Greco, Raffaella, additional, Forcina, Alessandra, additional, Guggiari, Elena, additional, Lunghi, Francesca, additional, Girlanda, Stefania, additional, Perini, Tommaso, additional, Pavesi, Francesca, additional, Marktel, Sarah, additional, Assanelli, Andrea, additional, Marcatti, Magda, additional, Carrabba, Matteo G, additional, Giglio, Fabio, additional, Bernardi, Massimo, additional, Corti, Consuelo, additional, Peccatori, Jacopo, additional, Bonini, Chiara, additional, Bordignon, Claudio, additional, and Ciceri, Fabio, additional

Published
2014
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33. Rapid Molecular Detection of Pathogens in 516 Consecutive Haematological Patients with Febrile Neutropenia

Author

Greco, Raffaella, primary, Barbanti, Maria Chiara, additional, Mancini, Nicasio, additional, Crucitti, Lara, additional, Forcina, Alessandra, additional, Lorentino, Francesca, additional, Orsini, Alessia, additional, Vago, Luca, additional, Giglio, Fabio, additional, Lupo Stanghellini, Maria Teresa, additional, Clerici, Daniela, additional, Carrabba, Matteo G, additional, Marktel, Sarah, additional, Assanelli, Andrea, additional, Marcatti, Magda, additional, Bernardi, Massimo, additional, Corti, Consuelo, additional, Peccatori, Jacopo, additional, Clementi, Massimo, additional, and Ciceri, Fabio, additional

Published
2014
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34. A novel self-lipid antigen targets human T cells against CD1c+ leukemias

Author

Lepore, Marco, primary, de Lalla, Claudia, additional, Gundimeda, S. Ramanjaneyulu, additional, Gsellinger, Heiko, additional, Consonni, Michela, additional, Garavaglia, Claudio, additional, Sansano, Sebastiano, additional, Piccolo, Francesco, additional, Scelfo, Andrea, additional, Häussinger, Daniel, additional, Montagna, Daniela, additional, Locatelli, Franco, additional, Bonini, Chiara, additional, Bondanza, Attilio, additional, Forcina, Alessandra, additional, Li, Zhiyuan, additional, Ni, Guanghui, additional, Ciceri, Fabio, additional, Jenö, Paul, additional, Xia, Chengfeng, additional, Mori, Lucia, additional, Dellabona, Paolo, additional, Casorati, Giulia, additional, and De Libero, Gennaro, additional

Published
2014
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35. Ventilation Heterogeneity Of Peripheral Airways (Sacin*VT) Assessed By Nitrogen Multiple Breath Washout (N2-MBW) Is An Accurate and Sensitive Marker Of Bronchiolitis Obliterans Following Haematopoietic Stem Cell Transplantation Recipients

Author

De Giacomi, Federica, primary, Lupo-Stanghellini, Maria Teresa, additional, Orsini, Alessia, additional, Guggiari, Elena, additional, Corti, Consuelo, additional, Forcina, Alessandra, additional, Piemontese, Simona, additional, Pavesi, Francesca, additional, Peccatori, Jacopo, additional, Bernardi, Massimo, additional, Assanelli, Andrea, additional, Bonini, Chiara, additional, Cremona, George, additional, and Ciceri, Fabio, additional

Published
2013
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36. Post-Transplant Cyclophosphamide Haplo-HSCT Revised: Peripheral Blood Stem Cell Graft and Sirolimus To Enhance Immune Reconstitution and Graft Versus Leukemia Effect In Patients With Active Leukemia

Author

Cieri, Nicoletta, primary, Greco, Raffaella, additional, Morelli, Mara, additional, Giglio, Fabio, additional, Assanelli, Andrea, additional, Forcina, Alessandra, additional, Stanghellini, Maria Teresa Lupo, additional, Bernardi, Massimo, additional, Corti, Consuelo, additional, Bonini, Chiara, additional, Ciceri, Fabio, additional, and Peccatori, Jacopo, additional

Published
2013
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37. Human Herpes Virus 6 Reactivation and Disease After Allogeneic Hematopoietic Stem Cell Transplantation

Author

Greco, Raffaella, primary, Lorentino, Francesca, additional, Crucitti, Lara, additional, Vago, Luca, additional, Lupo Stanghellini, Maria Teresa, additional, Forcina, Alessandra, additional, Giglio, Fabio, additional, Morelli, Mara, additional, Carbone, Maria Rosaria, additional, Valtolina, Veronica, additional, Noviello, Maddalena, additional, Marktel, Sarah, additional, Assanelli, Andrea, additional, Marcatti, Magda, additional, Peccatori, Jacopo, additional, Bernardi, Massimo, additional, Bonini, Chiara, additional, Ciceri, Fabio, additional, and Corti, Consuelo, additional

Published
2013
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38. Intensification Of Treosulfan and Fludarabine-Based Conditioning With 4 Gy TBI For Allogeneic Stem Cell Transplantation In Patients With Hematological Malignancies

Author

Giglio, Fabio, primary, Brambilla, Corrado Zuanelli, additional, Lorentino, Francesca, additional, Piemontese, Simona, additional, Crucitti, Lara, additional, Levati, Giorgia, additional, Greco, Raffaella, additional, Morelli, Mara, additional, Messina, Carlo, additional, Forcina, Alessandra, additional, Stanghellini, Maria Teresa Lupo, additional, Vago, Luca, additional, Marktel, Sarah, additional, Marcatti, Magda, additional, Assanelli, Andrea, additional, Corti, Consuelo, additional, Bernardi, Massimo, additional, Bonini, Chiara, additional, Ciceri, Fabio, additional, and Peccatori, Jacopo, additional

Published
2013
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39. Pharmacokinetics (PK) Study Of Antithymocyte Globulins Fresenius (ATG-F) Prior To Allogeneic Stem Cell Transplantation: Implications For Timing Of Graft and Early Adoptive Immunotherapy Infusions

Author

Mastaglio, Sara, primary, Forcina, Alessandra, additional, Seitz, Isabell, additional, Martinius, Holger, additional, Peccatori, Jacopo, additional, Bernardi, Massimo, additional, Clerici, Daniela, additional, Corti, Consuelo, additional, Crotta, Alessandro, additional, Stanghellini, Maria Teresa Lupo, additional, Messina, Carlo, additional, Bonini, Chiara, additional, and Ciceri, Fabio, additional

Published
2013
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40. Antifungal Prophylaxis with Posaconazole in Allogeneic Hematopoietic Stem Cell Transplantation Using Sirolimus for Prevention of Graft-Versus-Host Disease

Author

Greco, Raffaella, Barbanti, Maria Chiara, Forcina, Alessandra, Lupo Stanghellini, Maria Teresa, Giglio, Fabio, Morelli, Mara, Vago, Luca, Piemontese, Simona, Messina, Carlo, Sala, Elisa, Pavesi, Francesca, Marktel, Sarah, Carrabba, Matteo G, Assanelli, Andrea, Bernardi, Massimo, Peccatori, Jacopo, Corti, Consuelo, and Ciceri, Fabio

Published
2015
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41. Full Dose Treosulfan Based Reduced Toxicity Conditioning Regimen in Allogeneic Stem Cell Transplantation: Results in 123 Patients.

Author

Lorusso, Alessandro, primary, Crocchiolo, Roberto, additional, Messina, Carlo, additional, Giglio, Fabio, additional, Forcina, Alessandra, additional, Mastaglio, Sara, additional, Stanghellini, Maria Teresa Lupo, additional, Assanelli, Andrea, additional, Gattillo, Salvatore, additional, Fleischhauer, Katharina, additional, Marcatti, Magda, additional, Corti, Consuelo, additional, Bernardi, Massimo, additional, Bonini, Chiara, additional, Ciceri, Fabio, additional, and Peccatori, Jacopo, additional

Published
2012
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42. Early Reconstitution of T-Cell Immunity to CMV After HLA-Haploidentical Hematopoietic Stem Cell Transplantation Is a Strong Surrogate Biomarker for Lower Non-Relapse Mortality Rates

Author

Noviello, Maddalena, primary, Forcina, Alessandra, additional, Stanghellini, Maria Teresa Lupo, additional, Carrabba, Matteo, additional, Assanelli, Andrea, additional, Carbone, Maria Rosaria, additional, Magnani, Zulma, additional, Corti, Consuelo, additional, Bernardi, Massimo, additional, Peccatori, Jacopo, additional, Ciceri, Fabio, additional, Bonini, Chiara, additional, and Bondanza, Attilio, additional

Published
2012
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43. Evaluation of NIH-Defined Chronic Graft-Versus-Host-Disease in a Rapamycin-Based Haploidentical Stem Cell Transplantation: Analysis of 113 Consecutive Patients with High Risk Haematological Malignancies

Author

Lupo-Stanghellini, Maria Teresa, primary, Forcina, Alessandra, additional, Clerici, Daniela, additional, Bondanza, Attilio, additional, Assanelli, Andrea, additional, Carrabba, Matteo, additional, Marcatti, Magda, additional, Marktel, Sarah, additional, Guggiari, Elena, additional, Lunghi, Francesca, additional, Claudiani, Simone, additional, Levati, Giorgia, additional, Bordignon, Claudio, additional, Corti, Consuelo, additional, Bernardi, Massimo, additional, Bonini, Chiara, additional, Peccatori, Jacopo, additional, and Ciceri, Fabio, additional

Published
2012
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44. Cardiovascular Risk: Analysis of Known Factors in Patients After Treosulfan-Based Conditioning for Haploidentical and HLA-Identical Stem Cell Transplantation

Author

Forcina, Alessandra, primary, Lupo Stanghellini, Maria Teresa, additional, Greco, Raffaella, additional, Lorusso, Alessandro, additional, Clerici, Daniela, additional, Peccatori, Jacopo, additional, Bernardi, Massimo, additional, Lunghi, Francesca, additional, Marcatti, Magda, additional, Camba, Lionello, additional, Guggiari, Elena, additional, Assanelli, Andrea, additional, Bondanza, Attilio, additional, Carrabba, Matteo, additional, Marktel, Sarah, additional, Corti, Consuelo, additional, and Ciceri, Fabio, additional

Published
2011
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45. Rapid Detection of Pathogens Causing Sepsis in Neutropenic Hematologic Patients by a Multiplex PCR-Based Assay

Author

Greco, Raffaella, primary, Clerici, Daniela, additional, Mancini, Nicasio, additional, Lorentino, Francesca, additional, Matteazzi, Francesca, additional, Forcina, Alessandra, additional, Lupo Stanghellini, Maria Teresa, additional, Vago, Luca, additional, Crucitti, Lara, additional, Guggiari, Elena, additional, Marktel, Sarah, additional, Assanelli, Andrea, additional, Carrabba, Matteo, additional, Massimo, Bernardi, additional, Peccatori, Jacopo, additional, Bordignon, Claudio, additional, Clementi, Massimo, additional, Ciceri, Fabio, additional, and Corti, Consuelo, additional

Published
2011
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46. Human Herpes Virus-6 and Clinical Manifestations After Allogeneic Hematopoietic Stem Cell Transplantation

Author

Greco, Raffaella, primary, Lorentino, Francesca, additional, Clerici, Daniela, additional, Matteazzi, Francesca, additional, Forcina, Alessandra, additional, Vago, Luca, additional, Malato, Simona, additional, Stanghellini, Maria Teresa Lupo, additional, Carrabba, Matteo, additional, Assanelli, Andrea, additional, Marcatti, Magda, additional, Bernardi, Massimo, additional, Bordignon, Claudio, additional, Ciceri, Fabio, additional, and Corti, Consuelo, additional

Published
2011
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47. Immune Reconstitution and Immune Correlates of Clinical Outcome IN Acute LEUKEMIA PATIENTS Treated with Haploidentical STEM CELL TRANSPLANTATION.

Author

Forcina, Alessandra, primary, Noviello, Maddalena, additional, Valtolina, Veronica, additional, Bondanza, Attilio, additional, Clerici, Daniela, additional, Vago, Luca, additional, Mastaglio, Sara, additional, Lupo-Stanghellini, Maria Teresa, additional, Fleischhauer, Katharina, additional, Corti, Consuelo, additional, Bernardi, Massimo, additional, Peccatori, Jacopo, additional, Bordignon, Claudio, additional, Ciceri, Fabio, additional, and Bonini, Chiara, additional

Published
2009
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48. Rapamycin-Based GvHD Prophylaxis Is Effective in T-Cell Replete Unmanipulated Haploidentical Peripheral Stem Cell Transplantation for Advanced Haematological Malignancies: Results in 46 Patients.

Author

Peccatori, Jacopo, primary, Clerici, Daniela, additional, Messina, Carlo, additional, Forcina, Alessandra, additional, Bondanza, Attilio, additional, Crocchiolo, Roberto, additional, Stanghellini, Maria Teresa Lupo, additional, Assanelli, Andrea, additional, Marcatti, Magda, additional, Giglio, Fabio, additional, Claudiani, Simone, additional, Mastaglio, Sara, additional, Malato, Simona, additional, Crotta, Alessandro, additional, Battaglia, Manuela, additional, Ronchi, Paola, additional, Gattillo, Salvatore, additional, Rossini, Silvano, additional, Corti, Consuelo, additional, Bernardi, Massimo, additional, Marktel, Sarah, additional, Bernardo, Maria Ester, additional, Bonini, Chiara, additional, Roncarolo, Maria Grazia, additional, Locatelli, Franco, additional, and Ciceri, Fabio, additional

Published
2009
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49. Efficacy and Safety of Tisagenlecleucel in Adult Patients with Relapsed/Refractory Follicular Lymphoma: Interim Analysis of the Phase 2 Elara Trial

Author

Fowler, Nathan, Dickinson, Michael, Dreyling, Martin, Martinez-Lopez, Joaquin, Kolstad, Arne, Butler, Jason, Ghosh, Monalisa, Popplewell, Leslie, Chavez, Julio C., Bachy, Emmanuel, Kato, Koji, Harigae, Hideo, Kersten, Marie José, Andreadis, Charalambos, Riedell, Peter A., Ho, P Joy, Pérez Simón, José Antonio, Nagle, Sarah, Nastoupil, Loretta J., von Tresckow, Bastian, María Ferreri, Andrés José, Teshima, Takanori, Patten, Piers EM, McGuirk, Joseph P, Petzer, Andreas, Offner, Fritz, Viardot, Andreas, Zinzani, Pierluigi, Malladi, Ram, Pacaud, Lida B., Forcina, Alessandra, Zia, Aiesha, Schuster, Stephen J., and Thieblemont, Catherine

Published
2021
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50. Clinical Impact of Pretransplant Multidrug-Resistant Gram-Negative Colonization in Autologous and Allogeneic Hematopoietic Stem Cell Transplantation

Author

Francesca Lorentino, Fabio Ciceri, Chiara Oltolini, Alessandra Forcina, Matteo Carrabba, Raffaella Greco, Massimo Bernardi, Jacopo Peccatori, Maria Teresa Lupo-Stanghellini, Magda Marcatti, Consuelo Corti, Vincenzo Marasco, Forcina, Alessandra, Lorentino, Francesca, Marasco, Vincenzo, Oltolini, Chiara, Marcatti, Magda, Greco, Raffaella, Lupo-Stanghellini, Maria Teresa, Carrabba, Matteo, Bernardi, Massimo, Peccatori, Jacopo, Corti, Consuelo, and Ciceri, Fabio

Subjects
Adult, Male, medicine.medical_specialty, Multivariate analysis, Transplantation Conditioning, medicine.medical_treatment, chemical and pharmacologic phenomena, Bacteremia, Disease, Hematopoietic stem cell transplantation, Gastroenterology, Transplantation, Autologous, 03 medical and health sciences, Young Adult, 0302 clinical medicine, immune system diseases, hemic and lymphatic diseases, Internal medicine, Drug Resistance, Multiple, Bacterial, Overall survival, Medicine, Humans, Transplantation, Homologous, Colonization, Gram, Aged, Transplantation, business.industry, Hematopoietic Stem Cell Transplantation, Hematology, Middle Aged, Independent factor, Multiple drug resistance, surgical procedures, operative, Multidrug-resistant Gram-negative bacteria, 030220 oncology & carcinogenesis, HSCT, Female, business, Pretransplant colonization, 030215 immunology
Abstract

Multidrug-resistant Gram-negative bacteria (MDR-GNB) are an emerging cause of morbidity and mortality after hematopoietic stem cell transplantation (HSCT). Three-hundred forty-eight consecutive patients transplanted at our hospital from July 2012 to January 2016 were screened for a pretransplant MDR-GNB colonization and evaluated for clinical outcomes. A pretransplant MDR-GNB colonization was found in 16.9% of allo-HSCT and in 9.6% of auto-HSCT recipients. Both in auto- and in allo-HSCT, carriers of a MDR-GNB showed no significant differences in overall survival (OS), transplant-related mortality (TRM), or infection-related mortality (IRM) compared with noncarriers. OS at 2 years for carriers compared with noncarriers was 85% versus 81% (P =.262) in auto-HSCT and 50% versus 43% (P =.091) in allo-HSCT. TRM at 2 years was 14% versus 5% (P =.405) in auto-HSCT and 31% versus 25% (P =.301) in allo-HSCT. IRM at 2 years was 14% versus 2% (P =.142) in auto-HSCT and 23% versus 14% (P =.304) in allo-HSCT. In multivariate analysis, only grade III to IV acute graft-versus-host disease was an independent factor for reduced OS (P

Published
2018

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