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1. Distribution of different classes of CSF3R mutations and co-mutational pattern in 360 myeloid neoplasia

Author

Maffei, Rossana, Paolini, Ambra, Conte, Benedetta, Riva, Giovanni, Nasillo, Vincenzo, Cretì, Federica, Martinelli, Silvia, Giacobbi, Francesca, Corradini, Giorgia, Pilato, Flora, Bernabei, Daniela, Lancellotti, Cesare, Debbia, Giulia, Morselli, Monica, Potenza, Leonardo, Giusti, Davide, Colaci, Elisabetta, Bettelli, Francesca, Bresciani, Paola, Cuoghi, Angela, Gilioli, Andrea, Messerotti, Andrea, Pioli, Valeria, Maccaferri, Monica, Leonardi, Giovanna, Manfredini, Rossella, Marasca, Roberto, Eccher, Albino, Luppi, Mario, Forghieri, Fabio, Candoni, Anna, and Tagliafico, Enrico

Published
2025
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2. Management of latent tuberculosis infection (LTBI) in adult patients with newly diagnosed acute leukemia: results of a survey among Italian centers belonging to SEIFEM (Sorveglianza Epidemiologica Infezioni nelle Emopatie) group

Author

Forghieri, Fabio, Bettelli, Francesca, Sgromo, Simona, Nadali, Gianpaolo, Del Principe, Maria Ilaria, Buzzatti, Elisa, Farina, Francesca, Cesini, Laura, Giordano, Antonio, Criscuolo, Marianna, Facchinelli, Davide, Piedimonte, Monica, Sartor, Chiara, De Marchi, Roberta, Delia, Mario, Mosna, Federico, Cudillo, Laura, Tolomelli, Giulia, Basilico, Claudia Maria, Cattaneo, Chiara, Fracchiolla, Nicola Stefano, Lessi, Federica, Finizio, Olimpia, Zannetti, Beatrice Anna, Santoni, Adele, Fazi, Paola, Marchesi, Francesco, Venditti, Adriano, Candoni, Anna, Luppi, Mario, Busca, Alessandro, and Pagano, Livio

Published
2024
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3. Antiviral prophylaxis to prevent herpes simplex virus (HSV) and varicella zoster virus (VZV) reactivation in adult patients with newly diagnosed acute leukemia: results of a survey submitted to Italian centers belonging to SEIFEM (Sorveglianza Epidemiologica Infezioni nelle Emopatie) group

Author

Forghieri, Fabio, Cordella, Stefano, Marchesi, Francesco, Itri, Federico, Del Principe, Maria Ilaria, Cavalieri, Elena, Pasciolla, Crescenza, Bonanni, Matteo, Criscuolo, Marianna, Fiorentini, Alessandro, Guolo, Fabio, Buquicchio, Caterina, Prezioso, Lucia, Delia, Mario, Melillo, Lorella, Audisio, Ernesta, Zannier, Maria Elena, Cerchione, Claudio, Dargenio, Michelina, Cattaneo, Chiara, Fracchiolla, Nicola Stefano, Pezone, Sara, Perruccio, Katia, Santoni, Adele, Candoni, Anna, Vignetti, Marco, Luppi, Mario, Pagano, Livio, and Busca, Alessandro

Published
2024
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4. The dynamic functions of IRF4 in B cell malignancies

Author

Maffei, Rossana, Fiorcari, Stefania, Atene, Claudio Giacinto, Martinelli, Silvia, Mesini, Nicolò, Pilato, Flora, Lagreca, Ivana, Barozzi, Patrizia, Riva, Giovanni, Nasillo, Vincenzo, Paolini, Ambra, Forghieri, Fabio, Potenza, Leonardo, Trenti, Tommaso, Tagliafico, Enrico, Luppi, Mario, and Marasca, Roberto

Published
2023
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5. Vancomycin resistant enterococcus risk factors for hospital colonization in hematological patients: a matched case-control study

Author

Meschiari, Marianna, Kaleci, Shaniko, Monte, Martina Del, Dessilani, Andrea, Santoro, Antonella, Scialpi, Francesco, Franceschini, Erica, Orlando, Gabriella, Cervo, Adriana, Monica, Morselli, Forghieri, Fabio, Venturelli, Claudia, Ricchizzi, Enrico, Chester, Johanna, Sarti, Mario, Guaraldi, Giovanni, Luppi, Mario, and Mussini, Cristina

Published
2023
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6. Predicting the next pandemic: VACCELERATE ranking of the WorldHealth Organization's Blueprint forAction toPreventEpidemics

Author

Busch, Martin, Seifert, Ulrike, Widmer, Andreas, Nagao, Miki, Rello, Jordi, Todorova, Tatina, Cviljević, Sabina, Heath, Christopher H., Jančorienė, Ligita, Fischer, Thea Koelsen, Orth, Hans Martin, Johansen, Isik Somuncu, Doymaz, Mehmet, Tragiannidis, Athanasios, Löscher, Thomas, Xu, Jin-Fu, Husa, Petr, Oteo, José Antonio, Issack, Mohammad I., Zeitlinger, Markus, Le Grand, Roger, Zdziarski, Przemysław, Demirkan, Fatih, Amador, Paloma Merino, García-Lozano, Tomás, Cao, Qing, Vázquez, Lourdes, Caeiro, Juan Pablo, Hermans, Peter, Nahrwar, Shahroch, Avsar, Korkut, Kumar, Deepak, Fernández, Norma, Mardani, Masoud, Segal, Esther, Pan, Angelo, Gkentzi, Despoina, Gioula, Georgia, Cortés, Jorge Alberto, Oliveira, Joaquim, van Damme, Pierre, Bin Mohd Zaili, Mohd Zaki, Antinori, Spinello, Zablockienė, Birutė, Papazisis, Georgios, Aneke, Chioma Inyang, Valerio, Maricela, McConkey, Samuel, Aujayeb, Avinash, Azzini, Anna Maria, Roganović, Jelena, Greve-Isdahl Mohn, Kristin, Kremsner, Peter, Gkrania-Klotsas, Effrossyni, Corzo, Dora, Khanna, Nina, Smiatacz, Tomasz, Scheithauer, Simone, Merelli, Maria, Klempa, Boris, Vrḫovac, Radovan, Ruggiero, Antonio, Chaudhary, Pankaj, Maquera-Afaray, Julio, Ekkelenkamp, Miquel, Jindra, Pavel, Pantić, Nikola, Guerra, Gemma Jiménez, Weiss, Guenter, Roohi, Behrad, Argyropoulos, Christos D., Silfverdal, Sven Aprne, van Praet, Jens, Bal, Zumrut Sahbudak, Kanj, Souha, Young, Barnaby, Pana, Zoi Dorothea, Roilides, Emmanuel, Stearns, Stephen C., Wauters, Joost, Baño, Jesús Rodríguez, Pletz, Mathias W., Travar, Maja, Kühn, Steven, Riera, Fernando, Cornely, Daniel, Laura, Vlad Jeni, Koehler, Philipp, Eley, Brian, Nair, Pravin K., Ciesek, Sandra, Olaru, Ioana Diana, Marques, Laura, Pontali, Emanuele, Naunheim, Alexandra, Lieb, Adrian, Gerhard, Markus, Farooqi, Joveria Qais, Turtle, Lance, Méndez, Gustavo Adolfo, Cox, Rebecca Jane, Goodman, Nigel, Caceca, Billie, Pemán, Javier, Dawood, Halima, Askling, Helena Hervius, Fomsgaard, Anders, Hernández, Alejandra Calderón, Staehelin, Cornelia, Liu, Chia-Ying, Icardi, Giancarlo, Castagnola, Elio, Salzer, Helmut J.F., Lundgren, Jens, Javadli, Samir, Forghieri, Fabio, Salmanton-García, Jon, Wipfler, Pauline, Leckler, Janina, Nauclér, Pontus, Mallon, Patrick W., Bruijning-Verhagen, Patricia C.J.L., Schmitt, Heinz-Joseph, Bethe, Ullrich, Olesen, Ole F., Stewart, Fiona A., Albus, Kerstin, and Cornely, Oliver A.

Published
2024
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7. Multicenter retrospective analysis of clinical outcome of adult patients with mixed-phenotype acute leukemia treated with acute myeloid leukemia–like or acute lymphoblastic leukemia–like chemotherapy and impact of allogeneic stem cell transplantation: a Campus ALL study

Author

Lazzarotto, Davide, Tanasi, Ilaria, Vitale, Antonella, Piccini, Matteo, Dargenio, Michelina, Giglio, Fabio, Forghieri, Fabio, Fracchiolla, Nicola, Cerrano, Marco, Todisco, Elisabetta, Papayannidis, Cristina, Leoncin, Matteo, Defina, Marzia, Guolo, Fabio, Pasciolla, Crescenza, Delia, Mario, Chiusolo, Patrizia, Mulè, Antonino, Candoni, Anna, Bonifacio, Massimiliano, Pizzolo, Giovanni, and Foà, Robin

Published
2023
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8. Feasibility of autologous peripheral blood stem cell mobilization and harvest in adult patients with FLT3-mutated acute myeloid leukemia receiving chemotherapy combined with midostaurin: a single-center experience

Author

Cordella, Stefano, Parisotto, Angelica, Bettelli, Francesca, Morselli, Monica, Barbieri, Emiliano, Pozzi, Stefano, Aquilino, Anna, Repaci, Gianluca, Cuoghi, Angela, Bresciani, Paola, Messerotti, Andrea, Colasante, Corrado, Gilioli, Andrea, Pioli, Valeria, Giusti, Davide, Colaci, Elisabetta, Cassanelli, Luca, Ceccherelli, Giovanni, Bevini, Mirco, Malavolti, Roberta, Venturelli, Donatella, Paolini, Ambra, Martinelli, Silvia, Maffei, Rossana, Riva, Giovanni, Nasillo, Vincenzo, Trenti, Tommaso, Comoli, Patrizia, Tagliafico, Enrico, Manfredini, Rossella, Barozzi, Patrizia, Potenza, Leonardo, Marasca, Roberto, Luppi, Mario, and Forghieri, Fabio

Published
2023
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9. Genomic and clinical findings in myeloid neoplasms with PDGFRB rearrangement

Author

Di Giacomo, Danika, Quintini, Martina, Pierini, Valentina, Pellanera, Fabrizia, La Starza, Roberta, Gorello, Paolo, Matteucci, Caterina, Crescenzi, Barbara, Fiumara, Paolo Fabio, Veltroni, Marinella, Borlenghi, Erika, Albano, Francesco, Forghieri, Fabio, Maccaferri, Monica, Bettelli, Francesca, Luppi, Mario, Cuneo, Antonio, Rossi, Giuseppe, and Mecucci, Cristina

Published
2022
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10. Long-term survival can be achieved in a significant fraction of older patients with core binding factor acute myeloid leukemia treated with intensive chemotherapy

Author

Mosna, F, Borlenghi, E, Litzow, M, Byrd, J, Papayannidis, C, Tecchio, C, Ferrara, F, Marcucci, G, Cairoli, R, Morgan, E, Gurrieri, C, Yeung, C, Deeg, H, Capelli, D, Candoni, A, Gotlib, J, Lunghi, M, Pullarkat, S, Lanza, F, Galimberti, S, Forghieri, F, Venditti, A, Festuccia, M, Audisio, E, Marvalle, D, Rigolin, G, Roti, G, Dibona, E, Visani, G, Albano, F, Eisfeld, A, Valent, P, Huls, G, Borthakur, G, Krampera, M, Martinelli, G, Kröger, N, Sperotto, A, Gottardi, M, Mosna, Federico, Borlenghi, Erika, Litzow, Mark, Byrd, John C, Papayannidis, Cristina, Tecchio, Cristina, Ferrara, Felicetto, Marcucci, Guido, Cairoli, Roberto, Morgan, Elizabeth A, Gurrieri, Carmela, Yeung, Cecilia C S, Deeg, H Joachim, Capelli, Debora, Candoni, Anna, Gotlib, Jason R, Lunghi, Monia, Pullarkat, Sheeja, Lanza, Francesco, Galimberti, Sara, Forghieri, Fabio, Venditti, Adriano, Festuccia, Moreno, Audisio, Ernesta, Marvalle, Denise, Rigolin, Gian Matteo, Roti, Giovanni, DiBona, Eros, Visani, Giuseppe, Albano, Francesco, Eisfeld, Ann-Kathrin, Valent, Peter, Huls, Gerwin, Borthakur, Gautam, Krampera, Mauro, Martinelli, Giovanni, Kröger, Nicolaus, Sperotto, Alessandra, Gottardi, Michele, Mosna, F, Borlenghi, E, Litzow, M, Byrd, J, Papayannidis, C, Tecchio, C, Ferrara, F, Marcucci, G, Cairoli, R, Morgan, E, Gurrieri, C, Yeung, C, Deeg, H, Capelli, D, Candoni, A, Gotlib, J, Lunghi, M, Pullarkat, S, Lanza, F, Galimberti, S, Forghieri, F, Venditti, A, Festuccia, M, Audisio, E, Marvalle, D, Rigolin, G, Roti, G, Dibona, E, Visani, G, Albano, F, Eisfeld, A, Valent, P, Huls, G, Borthakur, G, Krampera, M, Martinelli, G, Kröger, N, Sperotto, A, Gottardi, M, Mosna, Federico, Borlenghi, Erika, Litzow, Mark, Byrd, John C, Papayannidis, Cristina, Tecchio, Cristina, Ferrara, Felicetto, Marcucci, Guido, Cairoli, Roberto, Morgan, Elizabeth A, Gurrieri, Carmela, Yeung, Cecilia C S, Deeg, H Joachim, Capelli, Debora, Candoni, Anna, Gotlib, Jason R, Lunghi, Monia, Pullarkat, Sheeja, Lanza, Francesco, Galimberti, Sara, Forghieri, Fabio, Venditti, Adriano, Festuccia, Moreno, Audisio, Ernesta, Marvalle, Denise, Rigolin, Gian Matteo, Roti, Giovanni, DiBona, Eros, Visani, Giuseppe, Albano, Francesco, Eisfeld, Ann-Kathrin, Valent, Peter, Huls, Gerwin, Borthakur, Gautam, Krampera, Mauro, Martinelli, Giovanni, Kröger, Nicolaus, Sperotto, Alessandra, and Gottardi, Michele

Abstract

Acute Myeloid Leukemia is mainly a disease of the elderly: however, the knowledge on the outcomes of treatment in core binding factor AML (CBFAML) in older population, is limited. We retrospectively collected data on 229 patients with CBF- AML followed long-term in the last two decades. A 5-year overall survival (OS) of 44.2% (95%CI, 39.9-47.5) and a 5-year event - free survival (EFS) of 32.9% (95%CI, 25.5-40.1) was observed. In a subgroup of >70-year patients who completed intensive therapy (induction + >3 courses of consolidation including autologous stem cell transplant: 10 patients) the median EFS was 11.8 months (95%CI, 9.4 - 15.2) and OS was 40.0% (95%CI, 36.4 - 44.1) at 5yr. In univariate analysis, age >70 (hazard ratio (HR) 1.78, [95%CI, 1.15 - 2.54], p=.008), failure to achieve remission following induction (HR, 8.96 [95%CI, 5.5 - 13.8], p=<.0001), no consolidation therapy (HR, 0.75 [95%CI, 0.47 - 1.84], p=.04) and less than 3 cycles of consolidation (HR, 1.48 [95%CI, 0.75 - 3.2], p=.0004), predicted poorer EFS. Our study shows that intensive therapy, in selected older CBF-AML patients, leads to longer survival. Achieving a CR seems to be the most important first step and at least 3 cycles of consolidation, an important second one. The analysis suggests that these patients should not be excluded from studies with intensive therapies.

Published
2024

11. Predicting the next pandemic: VACCELERATE ranking of the World Health Organization's Blueprint for Action to Prevent Epidemics

Author

Hart- en Vaatziekten Team A, Epi Infectieziekten Team 1, Child Health, Infection & Immunity, JC onderzoeksprogramma Infectious Diseases, MMB Medische Staf, Salmanton-García, Jon, Wipfler, Pauline, Leckler, Janina, Nauclér, Pontus, Mallon, Patrick W., Bruijning-Verhagen, Patricia C.J.L., Schmitt, Heinz Joseph, Bethe, Ullrich, Olesen, Ole F., Stewart, Fiona A., Albus, Kerstin, Cornely, Oliver A., Busch, Martin, Seifert, Ulrike, Widmer, Andreas, Nagao, Miki, Rello, Jordi, Todorova, Tatina, Cviljević, Sabina, Heath, Christopher H., Jančorienė, Ligita, Fischer, Thea Koelsen, Orth, Hans Martin, Johansen, Isik Somuncu, Doymaz, Mehmet, Tragiannidis, Athanasios, Löscher, Thomas, Xu, Jin Fu, Husa, Petr, Oteo, José Antonio, Issack, Mohammad I., Zeitlinger, Markus, Le Grand, Roger, Zdziarski, Przemysław, Demirkan, Fatih, Amador, Paloma Merino, García-Lozano, Tomás, Cao, Qing, Vázquez, Lourdes, Caeiro, Juan Pablo, Hermans, Peter, Nahrwar, Shahroch, Avsar, Korkut, Kumar, Deepak, Fernández, Norma, Mardani, Masoud, Segal, Esther, Pan, Angelo, Gkentzi, Despoina, Gioula, Georgia, Cortés, Jorge Alberto, Oliveira, Joaquim, van Damme, Pierre, Bin Mohd Zaili, Mohd Zaki, Antinori, Spinello, Zablockienė, Birutė, Papazisis, Georgios, Aneke, Chioma Inyang, Valerio, Maricela, McConkey, Samuel, Aujayeb, Avinash, Azzini, Anna Maria, Roganović, Jelena, Greve-Isdahl Mohn, Kristin, Kremsner, Peter, Gkrania-Klotsas, Effrossyni, Corzo, Dora, Khanna, Nina, Smiatacz, Tomasz, Scheithauer, Simone, Merelli, Maria, Klempa, Boris, Vrḫovac, Radovan, Ruggiero, Antonio, Chaudhary, Pankaj, Maquera-Afaray, Julio, Ekkelenkamp, Miquel, Jindra, Pavel, Pantić, Nikola, Guerra, Gemma Jiménez, Weiss, Guenter, Roohi, Behrad, Argyropoulos, Christos D., Silfverdal, Sven Aprne, van Praet, Jens, Bal, Zumrut Sahbudak, Kanj, Souha, Young, Barnaby, Pana, Zoi Dorothea, Roilides, Emmanuel, Stearns, Stephen C., Wauters, Joost, Baño, Jesús Rodríguez, Pletz, Mathias W., Travar, Maja, Kühn, Steven, Riera, Fernando, Cornely, Daniel, Laura, Vlad Jeni, Koehler, Philipp, Eley, Brian, Nair, Pravin K., Ciesek, Sandra, Olaru, Ioana Diana, Marques, Laura, Pontali, Emanuele, Naunheim, Alexandra, Lieb, Adrian, Gerhard, Markus, Farooqi, Joveria Qais, Turtle, Lance, Méndez, Gustavo Adolfo, Cox, Rebecca Jane, Goodman, Nigel, Caceca, Billie, Pemán, Javier, Dawood, Halima, Askling, Helena Hervius, Fomsgaard, Anders, Hernández, Alejandra Calderón, Staehelin, Cornelia, Liu, Chia Ying, Icardi, Giancarlo, Castagnola, Elio, Salzer, Helmut J.F., Lundgren, Jens, Javadli, Samir, Forghieri, Fabio, Hart- en Vaatziekten Team A, Epi Infectieziekten Team 1, Child Health, Infection & Immunity, JC onderzoeksprogramma Infectious Diseases, MMB Medische Staf, Salmanton-García, Jon, Wipfler, Pauline, Leckler, Janina, Nauclér, Pontus, Mallon, Patrick W., Bruijning-Verhagen, Patricia C.J.L., Schmitt, Heinz Joseph, Bethe, Ullrich, Olesen, Ole F., Stewart, Fiona A., Albus, Kerstin, Cornely, Oliver A., Busch, Martin, Seifert, Ulrike, Widmer, Andreas, Nagao, Miki, Rello, Jordi, Todorova, Tatina, Cviljević, Sabina, Heath, Christopher H., Jančorienė, Ligita, Fischer, Thea Koelsen, Orth, Hans Martin, Johansen, Isik Somuncu, Doymaz, Mehmet, Tragiannidis, Athanasios, Löscher, Thomas, Xu, Jin Fu, Husa, Petr, Oteo, José Antonio, Issack, Mohammad I., Zeitlinger, Markus, Le Grand, Roger, Zdziarski, Przemysław, Demirkan, Fatih, Amador, Paloma Merino, García-Lozano, Tomás, Cao, Qing, Vázquez, Lourdes, Caeiro, Juan Pablo, Hermans, Peter, Nahrwar, Shahroch, Avsar, Korkut, Kumar, Deepak, Fernández, Norma, Mardani, Masoud, Segal, Esther, Pan, Angelo, Gkentzi, Despoina, Gioula, Georgia, Cortés, Jorge Alberto, Oliveira, Joaquim, van Damme, Pierre, Bin Mohd Zaili, Mohd Zaki, Antinori, Spinello, Zablockienė, Birutė, Papazisis, Georgios, Aneke, Chioma Inyang, Valerio, Maricela, McConkey, Samuel, Aujayeb, Avinash, Azzini, Anna Maria, Roganović, Jelena, Greve-Isdahl Mohn, Kristin, Kremsner, Peter, Gkrania-Klotsas, Effrossyni, Corzo, Dora, Khanna, Nina, Smiatacz, Tomasz, Scheithauer, Simone, Merelli, Maria, Klempa, Boris, Vrḫovac, Radovan, Ruggiero, Antonio, Chaudhary, Pankaj, Maquera-Afaray, Julio, Ekkelenkamp, Miquel, Jindra, Pavel, Pantić, Nikola, Guerra, Gemma Jiménez, Weiss, Guenter, Roohi, Behrad, Argyropoulos, Christos D., Silfverdal, Sven Aprne, van Praet, Jens, Bal, Zumrut Sahbudak, Kanj, Souha, Young, Barnaby, Pana, Zoi Dorothea, Roilides, Emmanuel, Stearns, Stephen C., Wauters, Joost, Baño, Jesús Rodríguez, Pletz, Mathias W., Travar, Maja, Kühn, Steven, Riera, Fernando, Cornely, Daniel, Laura, Vlad Jeni, Koehler, Philipp, Eley, Brian, Nair, Pravin K., Ciesek, Sandra, Olaru, Ioana Diana, Marques, Laura, Pontali, Emanuele, Naunheim, Alexandra, Lieb, Adrian, Gerhard, Markus, Farooqi, Joveria Qais, Turtle, Lance, Méndez, Gustavo Adolfo, Cox, Rebecca Jane, Goodman, Nigel, Caceca, Billie, Pemán, Javier, Dawood, Halima, Askling, Helena Hervius, Fomsgaard, Anders, Hernández, Alejandra Calderón, Staehelin, Cornelia, Liu, Chia Ying, Icardi, Giancarlo, Castagnola, Elio, Salzer, Helmut J.F., Lundgren, Jens, Javadli, Samir, and Forghieri, Fabio

Published
2024

12. Predicting the next pandemic: VACCELERATE ranking of the World Health Organization's Blueprint for Action to Prevent Epidemics

Author

Salmanton-García, Jon, primary, Wipfler, Pauline, additional, Leckler, Janina, additional, Nauclér, Pontus, additional, Mallon, Patrick W., additional, Bruijning-Verhagen, Patricia C.J.L., additional, Schmitt, Heinz-Joseph, additional, Bethe, Ullrich, additional, Olesen, Ole F., additional, Stewart, Fiona A., additional, Albus, Kerstin, additional, Cornely, Oliver A., additional, Busch, Martin, additional, Seifert, Ulrike, additional, Widmer, Andreas, additional, Nagao, Miki, additional, Rello, Jordi, additional, Todorova, Tatina, additional, Cviljević, Sabina, additional, Heath, Christopher H., additional, Jančorienė, Ligita, additional, Fischer, Thea Koelsen, additional, Orth, Hans Martin, additional, Johansen, Isik Somuncu, additional, Doymaz, Mehmet, additional, Tragiannidis, Athanasios, additional, Löscher, Thomas, additional, Xu, Jin-Fu, additional, Husa, Petr, additional, Oteo, José Antonio, additional, Issack, Mohammad I., additional, Zeitlinger, Markus, additional, Le Grand, Roger, additional, Zdziarski, Przemysław, additional, Demirkan, Fatih, additional, Amador, Paloma Merino, additional, García-Lozano, Tomás, additional, Cao, Qing, additional, Vázquez, Lourdes, additional, Caeiro, Juan Pablo, additional, Hermans, Peter, additional, Nahrwar, Shahroch, additional, Avsar, Korkut, additional, Kumar, Deepak, additional, Fernández, Norma, additional, Mardani, Masoud, additional, Segal, Esther, additional, Pan, Angelo, additional, Gkentzi, Despoina, additional, Gioula, Georgia, additional, Cortés, Jorge Alberto, additional, Oliveira, Joaquim, additional, van Damme, Pierre, additional, Bin Mohd Zaili, Mohd Zaki, additional, Antinori, Spinello, additional, Zablockienė, Birutė, additional, Papazisis, Georgios, additional, Aneke, Chioma Inyang, additional, Valerio, Maricela, additional, McConkey, Samuel, additional, Aujayeb, Avinash, additional, Azzini, Anna Maria, additional, Roganović, Jelena, additional, Greve-Isdahl Mohn, Kristin, additional, Kremsner, Peter, additional, Gkrania-Klotsas, Effrossyni, additional, Corzo, Dora, additional, Khanna, Nina, additional, Smiatacz, Tomasz, additional, Scheithauer, Simone, additional, Merelli, Maria, additional, Klempa, Boris, additional, Vrḫovac, Radovan, additional, Ruggiero, Antonio, additional, Chaudhary, Pankaj, additional, Maquera-Afaray, Julio, additional, Ekkelenkamp, Miquel, additional, Jindra, Pavel, additional, Pantić, Nikola, additional, Guerra, Gemma Jiménez, additional, Weiss, Guenter, additional, Roohi, Behrad, additional, Argyropoulos, Christos D., additional, Silfverdal, Sven Aprne, additional, van Praet, Jens, additional, Bal, Zumrut Sahbudak, additional, Kanj, Souha, additional, Young, Barnaby, additional, Pana, Zoi Dorothea, additional, Roilides, Emmanuel, additional, Stearns, Stephen C., additional, Wauters, Joost, additional, Baño, Jesús Rodríguez, additional, Pletz, Mathias W., additional, Travar, Maja, additional, Kühn, Steven, additional, Riera, Fernando, additional, Cornely, Daniel, additional, Laura, Vlad Jeni, additional, Koehler, Philipp, additional, Eley, Brian, additional, Nair, Pravin K., additional, Ciesek, Sandra, additional, Olaru, Ioana Diana, additional, Marques, Laura, additional, Pontali, Emanuele, additional, Naunheim, Alexandra, additional, Lieb, Adrian, additional, Gerhard, Markus, additional, Farooqi, Joveria Qais, additional, Turtle, Lance, additional, Méndez, Gustavo Adolfo, additional, Cox, Rebecca Jane, additional, Goodman, Nigel, additional, Caceca, Billie, additional, Pemán, Javier, additional, Dawood, Halima, additional, Askling, Helena Hervius, additional, Fomsgaard, Anders, additional, Hernández, Alejandra Calderón, additional, Staehelin, Cornelia, additional, Liu, Chia-Ying, additional, Icardi, Giancarlo, additional, Castagnola, Elio, additional, Salzer, Helmut J.F., additional, Lundgren, Jens, additional, Javadli, Samir, additional, and Forghieri, Fabio, additional

Published
2024
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13. Identification and validation of diagnostic cut-offs of the ELISpot assay for the diagnosis of invasive aspergillosis in high-risk patients.

Author

Bettelli, Francesca, Vallerini, Daniela, Lagreca, Ivana, Barozzi, Patrizia, Riva, Giovanni, Nasillo, Vincenzo, Paolini, Ambra, D'Amico, Roberto, Forghieri, Fabio, Morselli, Monica, Pioli, Valeria, Gilioli, Andrea, Giusti, Davide, Messerotti, Andrea, Bresciani, Paola, Cuoghi, Angela, Colaci, Elisabetta, Marasca, Roberto, Pagano, Livio, and Candoni, Anna

Subjects
ASPERGILLOSIS, HEMATOLOGIC malignancies, T cells, SENSITIVITY & specificity (Statistics), INTERLEUKIN-10
Abstract

Objective: We investigated the performance of enzyme linked immunospot (ELISpot) assay for the diagnosis of invasive aspergillosis (IA) in high-risk patients with hematologic malignancies. Methods: We prospectively enrolled two cohorts of patients undergoing intensive myelosuppressive or immunosuppressive treatments at high risk for IA. ELISpot was performed to detect Aspergillus-specific T cells producing Interleukin-10. Results: In the discovery cohort, a derived cut-off of 40 spot forming cells (SFCs)/106 PBMCs has shown to correctly classify IA cases with a sensitivity and specificity of 89.5% and 88.6%, respectively. This cut-off is lowered to 25 SFC when considering the subset of possible IA patients, with sensitivity and specificity of 76% and 93%, respectively. The application of the 40 SFCs cut-off to the validation cohort resulted in a positivity rate of 83.3% in proven/probable cases and a negativity rate of 92.5% in possible/non-IA cases. Adopting the 25 SCFs cut-off, the assay resulted positive in 83.3% of proven/probable cases while it resulted negative in 66.7% of possible/non-IA cases. Conclusions: ELISpot shows promises in the diagnosis of IA and the possibility to use two distinct cut-offs with similar diagnostic performances according to patients' different pre-test probability of infection can widen its use in patients at risk. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Blinatumomab and Inotuzumab Ozogamicin Sequential Use for the Treatment of Relapsed/Refractory Acute Lymphoblastic Leukemia: A Real-Life Campus All Study

Author

Fracchiolla, Nicola Stefano, primary, Sciumè, Mariarita, additional, Papayannidis, Cristina, additional, Vitale, Antonella, additional, Chiaretti, Sabina, additional, Annunziata, Mario, additional, Giglio, Fabio, additional, Salutari, Prassede, additional, Forghieri, Fabio, additional, Lazzarotto, Davide, additional, Lunghi, Monia, additional, Imovilli, Annalisa, additional, Scappini, Barbara, additional, Bonifacio, Massimiliano, additional, Dargenio, Michelina, additional, Gurrieri, Carmela, additional, Todisco, Elisabetta, additional, Defina, Marzia, additional, Del Principe, Maria Ilaria, additional, Zappasodi, Patrizia, additional, Cerrano, Marco, additional, Santoro, Lidia, additional, Tagliaferri, Elena, additional, Barozzi, Enrico, additional, De Roberto, Pasquale, additional, Canzi, Marta, additional, Buzzatti, Elisa, additional, Sartor, Chiara, additional, Passamonti, Francesco, additional, Foà, Robin, additional, and Curti, Antonio, additional

Published
2023
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15. Characterization of FLT3-ITDmut acute myeloid leukemia: molecular profiling of leukemic precursor cells

Author

Travaglini, Serena, Angelini, Daniela Francesca, Alfonso, Valentina, Guerrera, Gisella, Lavorgna, Serena, Divona, Mariadomenica, Nardozza, Anna Maria, Consalvo, Maria Irno, Fabiani, Emiliano, De Bardi, Marco, Neri, Benedetta, Forghieri, Fabio, Marchesi, Francesco, Paterno, Giovangiacinto, Cerretti, Raffaella, Barragan, Eva, Fiori, Valentina, Dominici, Sabrina, Del Principe, Maria Ilaria, Venditti, Adriano, Battistini, Luca, Arcese, William, Lo-Coco, Francesco, Voso, Maria Teresa, and Ottone, Tiziana

Published
2020
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16. Investigating the association between physicians self-efficacy regarding communication skills and risk of “burnout”

Author

Messerotti, Andrea, Banchelli, Federico, Ferrari, Silvia, Barbieri, Emiliano, Bettelli, Francesca, Bandieri, Elena, Giusti, Davide, Catellani, Hillary, Borelli, Eleonora, Colaci, Elisabetta, Pioli, Valeria, Morselli, Monica, Forghieri, Fabio, Galeazzi, Gian Maria, Marasca, Roberto, Bigi, Sarah, D’Amico, Roberto, Martin, Peter, Efficace, Fabio, Luppi, Mario, and Potenza, Leonardo

Published
2020
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17. Preclinical Validation of an Advanced Therapy Medicinal Product Based on Cytotoxic T Lymphocytes Specific for Mutated Nucleophosmin (NPM1mut) for the Treatment of NPM1mut-Acute Myeloid Leukemia

Author

De Cicco, Marica, primary, Lagreca, Ivana, additional, Basso, Sabrina, additional, Barozzi, Patrizia, additional, Muscianisi, Stella, additional, Bianco, Alba, additional, Riva, Giovanni, additional, Di Vincenzo, Sara, additional, Pulvirenti, Chiara, additional, Sapuppo, Davide, additional, Siciliano, Mariangela, additional, Rosti, Vittorio, additional, Candoni, Anna, additional, Zecca, Marco, additional, Forghieri, Fabio, additional, Luppi, Mario, additional, and Comoli, Patrizia, additional

Published
2023
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18. Prognostic Relevance of Multi-Antigenic Myeloma-Specific T-Cell Assay in Patients with Monoclonal Gammopathies

Author

Lagreca, Ivana, primary, Nasillo, Vincenzo, additional, Barozzi, Patrizia, additional, Castelli, Ilaria, additional, Basso, Sabrina, additional, Castellano, Sara, additional, Paolini, Ambra, additional, Maccaferri, Monica, additional, Colaci, Elisabetta, additional, Vallerini, Daniela, additional, Natali, Patrizia, additional, Debbia, Daria, additional, Pirotti, Tommaso, additional, Ottomano, Anna Maria, additional, Maffei, Rossana, additional, Bettelli, Francesca, additional, Giusti, Davide, additional, Messerotti, Andrea, additional, Gilioli, Andrea, additional, Pioli, Valeria, additional, Leonardi, Giovanna, additional, Forghieri, Fabio, additional, Bresciani, Paola, additional, Cuoghi, Angela, additional, Morselli, Monica, additional, Manfredini, Rossella, additional, Longo, Giuseppe, additional, Candoni, Anna, additional, Marasca, Roberto, additional, Potenza, Leonardo, additional, Tagliafico, Enrico, additional, Trenti, Tommaso, additional, Comoli, Patrizia, additional, Luppi, Mario, additional, and Riva, Giovanni, additional

Published
2023
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19. The dynamic functions of IRF4 in B cell malignancies

Author

Maffei, Rossana, primary, Fiorcari, Stefania, additional, Atene, Claudio Giacinto, additional, Martinelli, Silvia, additional, Mesini, Nicolò, additional, Pilato, Flora, additional, Lagreca, Ivana, additional, Barozzi, Patrizia, additional, Riva, Giovanni, additional, Nasillo, Vincenzo, additional, Paolini, Ambra, additional, Forghieri, Fabio, additional, Potenza, Leonardo, additional, Trenti, Tommaso, additional, Tagliafico, Enrico, additional, Luppi, Mario, additional, and Marasca, Roberto, additional

Published
2022
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20. Feasibility of autologous peripheral blood stem cell mobilization and harvest in adult patients with FLT3-mutated acute myeloid leukemia receiving chemotherapy combined with midostaurin: a single-center experience

Author

Cordella, Stefano, primary, Parisotto, Angelica, additional, Bettelli, Francesca, additional, Morselli, Monica, additional, Barbieri, Emiliano, additional, Pozzi, Stefano, additional, Aquilino, Anna, additional, Repaci, Gianluca, additional, Cuoghi, Angela, additional, Bresciani, Paola, additional, Messerotti, Andrea, additional, Colasante, Corrado, additional, Gilioli, Andrea, additional, Pioli, Valeria, additional, Giusti, Davide, additional, Colaci, Elisabetta, additional, Cassanelli, Luca, additional, Ceccherelli, Giovanni, additional, Bevini, Mirco, additional, Malavolti, Roberta, additional, Venturelli, Donatella, additional, Paolini, Ambra, additional, Martinelli, Silvia, additional, Maffei, Rossana, additional, Riva, Giovanni, additional, Nasillo, Vincenzo, additional, Trenti, Tommaso, additional, Comoli, Patrizia, additional, Tagliafico, Enrico, additional, Manfredini, Rossella, additional, Barozzi, Patrizia, additional, Potenza, Leonardo, additional, Marasca, Roberto, additional, Luppi, Mario, additional, and Forghieri, Fabio, additional

Published
2022
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22. Epidemiology and clinical outcome of lower respiratory tract infections by respiratory syncytial virus or parainfluenza virus type 3 in adults receiving treatment for either acute leukemia or severe aplastic anemia: a retrospective single center study

Author

Bigliardi, Sara, Morselli, Monica, Potenza, Leonardo, Riva, Giovanni, Coluccio, Valeria, Maccaferri, Monica, Paolini, Ambra, Colaci, Elisabetta, Fantuzzi, Valeria, Soci, Francesco, Nasillo, Vincenzo, Messerotti, Andrea, Arletti, Laura, Pioli, Valeria, Lugli, Elisabetta, Gilioli, Andrea, Quadrelli, Chiara, Vallerini, Daniela, Barozzi, Patrizia, Lagreca, Ivana, Marasca, Roberto, Narni, Franco, Franceschini, Erica, Codeluppi, Mauro, Mussini, Cristina, Luppi, Mario, and Forghieri, Fabio

Published
2015
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23. Prevalence and Prognostic Role of IDH Mutations in Acute Myeloid Leukemia: Results of the GIMEMA AML1516 Protocol

Author

Messina, Monica, primary, Piciocchi, Alfonso, additional, Ottone, Tiziana, additional, Paolini, Stefania, additional, Papayannidis, Cristina, additional, Lessi, Federica, additional, Fracchiolla, Nicola Stefano, additional, Forghieri, Fabio, additional, Candoni, Anna, additional, Mengarelli, Andrea, additional, Martelli, Maria Paola, additional, Venditti, Adriano, additional, Carella, Angelo Michele, additional, Albano, Francesco, additional, Mancini, Valentina, additional, Massimo, Bernardi, additional, Arena, Valentina, additional, Sargentini, Valeria, additional, Sciumè, Mariarita, additional, Pastore, Domenico, additional, Todisco, Elisabetta, additional, Roti, Giovanni, additional, Siragusa, Sergio, additional, Ladetto, Marco, additional, Pravato, Stefano, additional, De Bellis, Eleonora, additional, Simonetti, Giorgia, additional, Marconi, Giovanni, additional, Cerchione, Claudio, additional, Fazi, Paola, additional, Vignetti, Marco, additional, Amadori, Sergio, additional, Martinelli, Giovanni, additional, and Voso, Maria Teresa, additional

Published
2022
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24. The Role of T Cell Immunity in Monoclonal Gammopathy and Multiple Myeloma: From Immunopathogenesis to Novel Therapeutic Approaches

Author

Lagreca, Ivana, primary, Riva, Giovanni, additional, Nasillo, Vincenzo, additional, Barozzi, Patrizia, additional, Castelli, Ilaria, additional, Basso, Sabrina, additional, Bettelli, Francesca, additional, Giusti, Davide, additional, Cuoghi, Angela, additional, Bresciani, Paola, additional, Messerotti, Andrea, additional, Gilioli, Andrea, additional, Pioli, Valeria, additional, Colasante, Corrado, additional, Vallerini, Daniela, additional, Paolini, Ambra, additional, Maccaferri, Monica, additional, Donatelli, Francesca, additional, Forghieri, Fabio, additional, Morselli, Monica, additional, Colaci, Elisabetta, additional, Leonardi, Giovanna, additional, Marasca, Roberto, additional, Potenza, Leonardo, additional, Manfredini, Rossella, additional, Tagliafico, Enrico, additional, Trenti, Tommaso, additional, Comoli, Patrizia, additional, and Luppi, Mario, additional

Published
2022
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25. COVID-19 infection in acute lymphoblastic leukemia over 15 months of the pandemic. A Campus ALL report

Author

Chiaretti, Sabina, primary, Bonifacio, Massimiliano, additional, Agrippino, Roberta, additional, Giglio, Fabio, additional, Annunziata, Mario, additional, Curti, Antonio, additional, Principe, Maria Ilaria Del, additional, Salutari, Prassede, additional, Sciumè, Mariarita, additional, Delia, Mario, additional, Armenio, Marco, additional, Mancini, Valentina, additional, Mulè, Antonino, additional, Grimaldi, Francesco, additional, Rege-Cambrin, Giovanna, additional, Santoro, Lidia, additional, Lussana, Federico, additional, Chiusolo, Patrizia, additional, Pasciolla, Crescenza, additional, Scattolin, Anna Maria, additional, Cerrano, Marco, additional, Ciccone, Maria, additional, Defina, Marzia, additional, Forghieri, Fabio, additional, Mazzone, Carla, additional, Piccini, Matteo, additional, Ferrara, Felicetto, additional, Pizzolo, Giovanni, additional, and Foà, Robin, additional

Published
2022
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26. In BCR-ABL1 Positive B-Cell Acute Lymphoblastic Leukemia, Steroid Therapy Induces Hypofibrinogenemia

Author

Buzzatti, Elisa, primary, Forghieri, Fabio, additional, Paterno, Giovangiacinto, additional, Marchesi, Francesco, additional, Sarlo, Chiara, additional, Giglio, Fabio, additional, Fracchiolla, Nicola, additional, Sciumè, Mariarita, additional, Palmieri, Raffaele, additional, Esposito, Fabiana, additional, Guarnera, Luca, additional, Mercante, Lisa, additional, Pascale, Maria Rosaria, additional, Mallegni, Flavia, additional, Savi, Arianna, additional, Forte, Vittorio, additional, Maurillo, Luca, additional, Buccisano, Francesco, additional, Venditti, Adriano, additional, and Del Principe, Maria Ilaria, additional

Published
2022
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27. BTK Inhibitors Impair Platelet-Mediated Antifungal Activity

Author

Nasillo, Vincenzo, primary, Lagreca, Ivana, additional, Vallerini, Daniela, additional, Barozzi, Patrizia, additional, Riva, Giovanni, additional, Maccaferri, Monica, additional, Paolini, Ambra, additional, Forghieri, Fabio, additional, Fiorcari, Stefania, additional, Maffei, Rossana, additional, Martinelli, Silvia, additional, Atene, Claudio Giacinto, additional, Castelli, Ilaria, additional, Marasca, Roberto, additional, Potenza, Leonardo, additional, Comoli, Patrizia, additional, Manfredini, Rossella, additional, Tagliafico, Enrico, additional, Trenti, Tommaso, additional, and Luppi, Mario, additional

Published
2022
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28. Daratumumab with or without chemotherapy in relapsed and refractory acute lymphoblastic leukemia. A retrospective observational Campus Acute Lymphoblastic Leukemia study

Author

Cerrano, Marco, Bonifacio, Massimiliano, Olivi, Matteo, Curti, Antonio, Malagola, Michele, Dargenio, Michelina, Scattolin, Anna Maria, Papayannidis, Cristina, Forghieri, Fabio, Gurrieri, Carmela, Tanasi, Ilaria, Zappasodi, Patrizia, La Starza, Roberta, Fracchiolla, Nicola Stefano, Chiusolo, Patrizia, Giaccone, Luisa, Del Principe, Maria Ilaria, Giglio, Fabio, Defina, Marzia, Favre, Claudio, Rizzari, Carmelo, Castella, Barbara, Pizzolo, Giovanni, Ferrara, Felicetto, Chiaretti, Sabina, and Foà, Robin

Subjects
Not available, Settore MED/15
Published
2022

30. Preclinical Validation of an Advanced Therapy Medicinal Product Based on Cytotoxic T Lymphocytes Specific for Mutated Nucleophosmin (NPM1 mut) for the Treatment of NPM1 mut -Acute Myeloid Leukemia.

Author

De Cicco, Marica, Lagreca, Ivana, Basso, Sabrina, Barozzi, Patrizia, Muscianisi, Stella, Bianco, Alba, Riva, Giovanni, Di Vincenzo, Sara, Pulvirenti, Chiara, Sapuppo, Davide, Siciliano, Mariangela, Rosti, Vittorio, Candoni, Anna, Zecca, Marco, Forghieri, Fabio, Luppi, Mario, and Comoli, Patrizia

Subjects
CYTOKINES, FLOW cytometry, CLINICAL drug trials, NUCLEOPHOSMIN, GENETIC mutation, MONONUCLEAR leukocytes, HUMAN research subjects, CELLULAR therapy, MANN Whitney U Test, INFORMED consent (Medical law), T-test (Statistics), IMMUNOPHENOTYPING, ENZYME-linked immunosorbent assay, CHI-squared test, DESCRIPTIVE statistics, RESEARCH funding, DRUG development, T cells, CELL surface antigens, HEMATOPOIETIC stem cells, HEMATOPOIETIC stem cell transplantation, DATA analysis software, IMMUNOTHERAPY, IMMUNODIAGNOSIS
Abstract

Simple Summary: Nearly 30% of adult acute myeloid leukemias (AML) harbor mutations of the nucleophosmin (NPM1) gene. These forms have a favorable outcome but, despite notable treatment advances, about 50% of patients still die of progressive disease. Thus, identification of new therapeutic opportunities is important to improve the prognosis. The aim of our study was to assess the feasibility of obtaining a cell therapy medicinal product specific for the mutated NPM1 protein from patients or healthy donors that could be employed to control leukemia and prevent hematologic relapse. We demonstrated that cytotoxic T cells specific for the mutated antigen can be reproducibly expanded, and these cells efficiently recognize and lyse leukemia blasts or other cell types carrying the NPM1-mutated antigen, without causing damage to normal hematopoietic cells. We believe that these T cells may integrate other therapy options in the treatment of patients with refractory or relapsed AML. Acute myeloid leukemia (AML) with nucleophosmin (NPM1) genetic mutations is the most common subtype in adult patients. Refractory or relapsed disease in unfit patients or after allogeneic hematopoietic stem cell transplantation (allo-HSCT) has a poor prognosis. NPM1-mutated protein, stably expressed on tumor cells but not on normal tissues, may serve as an ideal target for NPM1-mutated AML immunotherapy. The study aim was to investigate the feasibility of producing mutated-NPM1-specific cytotoxic T cells (CTLs) suitable for somatic cell therapy to prevent or treat hematologic relapse in patients with NPM1-mutated AML. T cells were expanded or primed from patient or donor peripheral blood mononuclear cells by NPM1-mutated protein-derived peptides, and tested for leukemia antigen-targeted cytotoxic activity, cytokine production and hematopoietic precursor inhibitory effect. We found that mutated-NPM1-specific CTLs, displaying specific cytokine production and high-level cytotoxicity against patients' leukemia blasts, and limited inhibitory activity in clonogenic assays, could be obtained from both patients and donors. The polyfunctional mutated-NPM1-specific CTLs included both CD8+ and CD4+ T cells endowed with strong lytic capacity. Our results suggest that mutated-NPM1-targeted CTLs may be a useful therapeutic option to control low-tumor burden relapse following conventional chemotherapy in older NPM1-mutated AML patients or eradicate persistent MRD after HSCT. [ABSTRACT FROM AUTHOR]

Published
2023
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31. Emergence of BCR-ABL–specific cytotoxic T cells in the bone marrow of patients with Ph+ acute lymphoblastic leukemia during long-term imatinib mesylate treatment

Author

Riva, Giovanni, Luppi, Mario, Barozzi, Patrizia, Quadrelli, Chiara, Basso, Sabrina, Vallerini, Daniela, Zanetti, Eleonora, Morselli, Monica, Forghieri, Fabio, Maccaferri, Monica, Volzone, Francesco, Del Giovane, Cinzia, D'Amico, Roberto, Locatelli, Franco, Torelli, Giuseppe, Comoli, Patrizia, and Potenza, Leonardo

Published
2010
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32. Daratumumab with or without chemotherapy in relapsed and refractory acute lymphoblastic leukemia. A retrospective observational Campus ALL study

Author

Cerrano, Marco, primary, Bonifacio, Massimiliano, additional, Olivi, Matteo, additional, Curti, Antonio, additional, Malagola, Michele, additional, Dargenio, Michelina, additional, Scattolin, Anna Maria, additional, Papayannidis, Cristina, additional, Forghieri, Fabio, additional, Gurrieri, Carmela, additional, Tanasi, Ilaria, additional, Zappasodi, Patrizia, additional, La Starza, Roberta, additional, Fracchiolla, Nicola Stefano, additional, Chiusolo, Patrizia, additional, Giaccone, Luisa, additional, Del Principe, Maria Ilaria, additional, Giglio, Fabio, additional, Defina, Marzia, additional, Favre, Claudio, additional, Rizzari, Carmelo, additional, Castella, Barbara, additional, Pizzolo, Giovanni, additional, Ferrara, Felicetto, additional, Chiaretti, Sabina, additional, and Foà, Robin, additional

Published
2022
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33. Multiparametric Flow Cytometry for MRD Monitoring in Hematologic Malignancies: Clinical Applications and New Challenges

Author

Riva, Giovanni, Nasillo, Vincenzo, Ottomano, Anna Maria, Bergonzini, Giuliano, Paolini, Ambra, Forghieri, Fabio, Lusenti, Beatrice, Barozzi, Patrizia, Lagreca, Ivana, Fiorcari, Stefania, Martinelli, Silvia, Maffei, Rossana, Marasca, Roberto, Potenza, Leonardo, Comoli, Patrizia, Manfredini, Rossella, Tagliafico, Enrico, Trenti, Tommaso, and Luppi, Mario

Subjects
body regions, MRD, myeloma, hemic and lymphatic diseases, flow cytometry, leukemia, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, lymphoma, Review, immunotherapy, Flow cytometry, Immunophenotype, Immunotherapy, Leukemia, Lymphoma, Myeloma, immunophenotype, RC254-282
Abstract

Simple Summary In hematologic cancers, Minimal Residual Disease (MRD) monitoring, using either molecular (PCR) or immunophenotypic (MFC) diagnostics, allows the identification of rare cancer cells, readily detectable either in the bone marrow or in the peripheral blood at very low levels, far below the limit of classic microscopy. In this paper, we outlined the state-of-the-art of MFC-based MRD detection in different hematologic settings, highlighting main recommendations and new challenges for using such method in patients with acute leukemias or chronic hematologic neoplasms. The combination of new molecular technologies with advanced flow cytometry is progressively allowing clinicians to design a personalized therapeutic path, proportionate to the biological aggressiveness of the disease, in particular by using novel immunotherapies, in view of a modern decision-making process, based on precision medicine. Abstract Along with the evolution of immunophenotypic and molecular diagnostics, the assessment of Minimal Residual Disease (MRD) has progressively become a keystone in the clinical management of hematologic malignancies, enabling valuable post-therapy risk stratifications and guiding risk-adapted therapeutic approaches. However, specific prognostic values of MRD in different hematological settings, as well as its appropriate clinical uses (basically, when to measure it and how to deal with different MRD levels), still need further investigations, aiming to improve standardization and harmonization of MRD monitoring protocols and MRD-driven therapeutic strategies. Currently, MRD measurement in hematological neoplasms with bone marrow involvement is based on advanced highly sensitive methods, able to detect either specific genetic abnormalities (by PCR-based techniques and next-generation sequencing) or tumor-associated immunophenotypic profiles (by multiparametric flow cytometry, MFC). In this review, we focus on the growing clinical role for MFC-MRD diagnostics in hematological malignancies—from acute myeloid and lymphoblastic leukemias (AML, B-ALL and T-ALL) to chronic lymphocytic leukemia (CLL) and multiple myeloma (MM)—providing a comparative overview on technical aspects, clinical implications, advantages and pitfalls of MFC-MRD monitoring in different clinical settings.

Published
2021

34. Genomic and clinical findings in myeloid neoplasms with PDGFRB rearrangement

Author

Di Giacomo, Danika, primary, Quintini, Martina, additional, Pierini, Valentina, additional, Pellanera, Fabrizia, additional, La Starza, Roberta, additional, Gorello, Paolo, additional, Matteucci, Caterina, additional, Crescenzi, Barbara, additional, Fiumara, Paolo Fabio, additional, Veltroni, Marinella, additional, Borlenghi, Erika, additional, Albano, Francesco, additional, Forghieri, Fabio, additional, Maccaferri, Monica, additional, Bettelli, Francesca, additional, Luppi, Mario, additional, Cuneo, Antonio, additional, Rossi, Giuseppe, additional, and Mecucci, Cristina, additional

Published
2021
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35. Complex karyotype, older age, and reduced first-line dose intensity determine poor survival in core binding factor acute myeloid leukemia patients with long-term follow-up

Author

Mosna, Federico, Papayannidis, Cristina, Martinelli, Giovanni, Di Bona, Eros, Bonalumi, Angela, Tecchio, Cristina, Candoni, Anna, Capelli, Debora, Piccin, Andrea, Forghieri, Fabio, Bigazzi, Catia, Visani, Giuseppe, Zambello, Renato, Zanatta, Lucia, Volpato, Francesca, Paolini, Stefania, Testoni, Nicoletta, Gherlinzoni, Filippo, and Gottardi, Michele

Published
2015
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36. ACUTE Lymphoblastic Leukemia (ALL) and COVID-19 Infection. a Campus ALL Report

Author

Chiaretti, Sabina, primary, Bonifacio, Massimiliano, additional, Agrippino, Roberta, additional, Annunziata, Mario, additional, Candoni, Anna, additional, Marco, Cerrano, additional, Cedrone, Michele, additional, Ciccone, Maria, additional, Chiusolo, Patrizia, additional, Curti, Antonio, additional, Dargenio, Michelina, additional, Defina, Marzia, additional, Delia, Mario, additional, Del Principe, Maria Ilaria, additional, Endri, Mauro, additional, Fava, Carmen, additional, Forghieri, Fabio, additional, Fiorentini, Alessandro, additional, Giglio, Fabio, additional, Grimaldi, Francesco, additional, Guolo, Fabio, additional, Lamanda, Michela, additional, Lunghi, Monia, additional, Lussana, Federico, additional, Mancini, Valentina, additional, Mazzone, Carla, additional, Mulè, Antonino, additional, Pasciolla, Crescenza, additional, Piccini, Matteo, additional, Rege Cambrin, Giovanna, additional, Salutari, Prassede, additional, Santoro, Lidia, additional, Scattolin, Anna Maria, additional, Sciumè, Mariarita, additional, Todisco, Elisabetta, additional, Ferrara, Felicetto, additional, Pizzolo, Giovanni, additional, and Foà, Robin, additional

Published
2021
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37. Blinatumomab and Inotuzumab for the Treatment of Multiply Relapsed Acute Lymphoblastic Leukemia: A Real-Life Campus ALL Study

Author

Sciumè, Mariarita, primary, Papayannidis, Cristina, additional, Curti, Antonio, additional, Vitale, Antonella, additional, Chiaretti, Sabina, additional, Annunziata, Mario, additional, Giglio, Fabio, additional, Salutari, Prassede, additional, Forghieri, Fabio, additional, Lazzarotto, Davide, additional, Lunghi, Monia, additional, Imovilli, Annalisa, additional, Scappini, Barbara, additional, Bonifacio, Massimiliano, additional, Dargenio, Michelina, additional, Gurrieri, Carmela, additional, Todisco, Elisabetta, additional, Defina, Marzia, additional, Del Principe, Maria Ilaria, additional, Zappasodi, Patrizia, additional, Cerrano, Marco, additional, Santoro, Lidia, additional, Barozzi, Enrico, additional, De Roberto, Pasquale, additional, Buzzatti, Elisa, additional, Sartor, Chiara, additional, Baldini, Luca, additional, Foa, Robin, additional, and Fracchiolla, Nicola S, additional

Published
2021
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38. Neoantigen-specific T-cell immune responses: The paradigm of NPM1-mutated acute myeloid leukemia

Author

Forghieri, Fabio, Riva, Giovanni, Lagreca, Ivana, Barozzi, Patrizia, Bettelli, Francesca, Paolini, Ambra, Nasillo, Vincenzo, Lusenti, Beatrice, Pioli, Valeria, Giusti, Davide, Gilioli, Andrea, Colasante, Corrado, Galassi, Laura, Catellani, Hillary, Donatelli, Francesca, Talami, Annalisa, Maffei, Rossana, Martinelli, Silvia, Potenza, Leonardo, Marasca, Roberto, Tagliafico, Enrico, Manfredini, Rossella, Trenti, Tommaso, Comoli, Patrizia, and Luppi, Mario

Subjects
Myeloid, QH301-705.5, T-Lymphocytes, Immune-checkpoint inhibitors, immune-checkpoint inhibitors, NPM1 mutation, Review, acute myeloid leukemia, Acute, Antigens, Neoplasm, Adoptive immunotherapy, Animals, Humans, Biology (General), Antigens, QD1-999, Acute myeloid leukemia, Leukemia, NPM1-mutated-specific T cells, Nuclear Proteins, Leukemia-specific neoantigen, Immunotherapy, Leukemia, Myeloid, Acute, Mutation, Nucleophosmin, Chemistry, leukemia-specific neoantigen, Neoplasm, adoptive immunotherapy
Abstract

The C-terminal aminoacidic sequence from NPM1-mutated protein, absent in normal human tissues, may serve as a leukemia-specific antigen and can be considered an ideal target for NPM1-mutated acute myeloid leukemia (AML) immunotherapy. Different in silico instruments and in vitro/ex vivo immunological platforms have identified the most immunogenic epitopes from NPM1-mutated protein. Spontaneous development of endogenous NPM1-mutated-specific cytotoxic T cells has been observed in patients, potentially contributing to remission maintenance and prolonged survival. Genetically engineered T cells, namely CAR-T or TCR-transduced T cells, directed against NPM1-mutated peptides bound to HLA could prospectively represent a promising therapeutic approach. Although either adoptive or vaccine-based immunotherapies are unlikely to be highly effective in patients with full-blown leukemia, these strategies, potentially in combination with immune-checkpoint inhibitors, could be promising in maintaining remission or preemptively eradicating persistent measurable residual disease, mainly in patients ineligible for allogeneic hematopoietic stem cell transplant (HSCT). Alternatively, neoantigen-specific donor lymphocyte infusion derived from healthy donors and targeting NPM1-mutated protein to selectively elicit graft-versus-leukemia effect may represent an attractive option in subjects experiencing post-HSCT relapse. Future studies are warranted to further investigate dynamics of NPM1-mutated-specific immunity and explore whether novel individualized immunotherapies may have potential clinical utility in NPM1-mutated AML patients.

Published
2021

39. Neoantigen-Specific T-Cell Immune Responses: The Paradigm of NPM1-Mutated Acute Myeloid Leukemia

Author

Forghieri, Fabio, primary, Riva, Giovanni, additional, Lagreca, Ivana, additional, Barozzi, Patrizia, additional, Bettelli, Francesca, additional, Paolini, Ambra, additional, Nasillo, Vincenzo, additional, Lusenti, Beatrice, additional, Pioli, Valeria, additional, Giusti, Davide, additional, Gilioli, Andrea, additional, Colasante, Corrado, additional, Galassi, Laura, additional, Catellani, Hillary, additional, Donatelli, Francesca, additional, Talami, Annalisa, additional, Maffei, Rossana, additional, Martinelli, Silvia, additional, Potenza, Leonardo, additional, Marasca, Roberto, additional, Tagliafico, Enrico, additional, Manfredini, Rossella, additional, Trenti, Tommaso, additional, Comoli, Patrizia, additional, and Luppi, Mario, additional

Published
2021
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40. How to Improve Prognostication in Acute Myeloid Leukemia with CBFB-MYH11 Fusion Transcript: Focus on the Role of Molecular Measurable Residual Disease (MRD) Monitoring

Author

Talami, Annalisa, primary, Bettelli, Francesca, additional, Pioli, Valeria, additional, Giusti, Davide, additional, Gilioli, Andrea, additional, Colasante, Corrado, additional, Galassi, Laura, additional, Giubbolini, Rachele, additional, Catellani, Hillary, additional, Donatelli, Francesca, additional, Maffei, Rossana, additional, Martinelli, Silvia, additional, Barozzi, Patrizia, additional, Potenza, Leonardo, additional, Marasca, Roberto, additional, Trenti, Tommaso, additional, Tagliafico, Enrico, additional, Comoli, Patrizia, additional, Luppi, Mario, additional, and Forghieri, Fabio, additional

Published
2021
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41. Multicenter Campus ALL Study on Infectious Complications in Ph- Acute Lymphoblastic Leukemia Patients Treated in the Real Life with the Gimema LAL1913 Protocol

Author

Zappasodi, Patrizia, Calabretta, Ludovica, Lazzarotto, Davide, Cerrano, Marco, Fracchiolla, Nicola, Papayannidis, Cristina, Lunghi, Monia, Forghieri, Fabio, Buzzatti, Elisa, Dargenio, Michelina, Pasciolla, Crescenza, Defina, Marzia, Guolo, Fabio, Mazzone, Carla, Roncoroni, Elisa, Rossi, Marianna, Chiaretti, Sabina, Pizzolo, Giovanni, Foà, Robin, and Candoni, Anna

Published
2023
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42. Do high MICs predict the outcome in invasive fusariosis?

Author

Nucci, Marcio, Jenks, Jeffrey, Thompson, George R., III, Hoenigl, Martin, Santos, Marielle Camargo dos, Forghieri, Fabio, Buil, J.B., Alastruey-Izquierdo, Ana, Pagano, Livio, Nucci, Marcio, Jenks, Jeffrey, Thompson, George R., III, Hoenigl, Martin, Santos, Marielle Camargo dos, Forghieri, Fabio, Buil, J.B., Alastruey-Izquierdo, Ana, and Pagano, Livio

Abstract

Item does not contain fulltext

Published
2021

43. A single-tube multiplex method for monitoring mutations in cysteine 481 of Bruton Tyrosine Kinase (BTK) gene in chronic lymphocytic leukemia patients treated with ibrutinib

Author

Maffei, Rossana, Fiorcari, Stefania, Atene, Claudio Giacinto, Martinelli, Silvia, Scarfo, Lydia, Bonfiglio, Silvia, Maccaferri, Monica, Ljungström, Viktor, Zucchini, Patrizia, Forghieri, Fabio, Potenza, Leonardo, Ghia, Paolo, Marasca, Roberto, Trenti, Tommaso, Tagliafico, Enrico, Luppi, Mario, Maffei, Rossana, Fiorcari, Stefania, Atene, Claudio Giacinto, Martinelli, Silvia, Scarfo, Lydia, Bonfiglio, Silvia, Maccaferri, Monica, Ljungström, Viktor, Zucchini, Patrizia, Forghieri, Fabio, Potenza, Leonardo, Ghia, Paolo, Marasca, Roberto, Trenti, Tommaso, Tagliafico, Enrico, and Luppi, Mario

Published
2021
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45. Inflammatory Microenvironment and Specific T Cells in Myeloproliferative Neoplasms: Immunopathogenesis and Novel Immunotherapies

Author

Nasillo, Vincenzo, primary, Riva, Giovanni, additional, Paolini, Ambra, additional, Forghieri, Fabio, additional, Roncati, Luca, additional, Lusenti, Beatrice, additional, Maccaferri, Monica, additional, Messerotti, Andrea, additional, Pioli, Valeria, additional, Gilioli, Andrea, additional, Bettelli, Francesca, additional, Giusti, Davide, additional, Barozzi, Patrizia, additional, Lagreca, Ivana, additional, Maffei, Rossana, additional, Marasca, Roberto, additional, Potenza, Leonardo, additional, Comoli, Patrizia, additional, Manfredini, Rossella, additional, Maiorana, Antonino, additional, Tagliafico, Enrico, additional, Luppi, Mario, additional, and Trenti, Tommaso, additional

Published
2021
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46. NPM1-Mutated Myeloid Neoplasms with <20% Blasts: A Really Distinct Clinico-Pathologic Entity?

Author

Forghieri, Fabio, primary, Nasillo, Vincenzo, additional, Paolini, Ambra, additional, Bettelli, Francesca, additional, Pioli, Valeria, additional, Giusti, Davide, additional, Gilioli, Andrea, additional, Colasante, Corrado, additional, Acquaviva, Gloria, additional, Riva, Giovanni, additional, Barozzi, Patrizia, additional, Maffei, Rossana, additional, Potenza, Leonardo, additional, Marasca, Roberto, additional, Fozza, Claudio, additional, Tagliafico, Enrico, additional, Trenti, Tommaso, additional, Comoli, Patrizia, additional, Longo, Giuseppe, additional, and Luppi, Mario, additional

Published
2020
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47. Nelarabine as salvage therapy and bridge to allogeneic stem cell transplant in 118 adult patients with relapsed/refractory T‐cell acute lymphoblastic leukemia/lymphoma. A CAMPUS ALL study

Author

Candoni, Anna, primary, Lazzarotto, Davide, additional, Ferrara, Felicetto, additional, Curti, Antonio, additional, Lussana, Federico, additional, Papayannidis, Cristina, additional, Del Principe, Maria Ilaria, additional, Bonifacio, Massimiliano, additional, Mosna, Federico, additional, Delia, Mario, additional, Minetto, Paola, additional, Gottardi, Michele, additional, Fracchiolla, Nicola, additional, Mancini, Valentina, additional, Forghieri, Fabio, additional, Zappasodi, Patrizia, additional, Cerrano, Marco, additional, Vitale, Antonella, additional, Audisio, Ernesta, additional, Trappolini, Silvia, additional, Romani, Claudio, additional, Defina, Marzia, additional, Imbergamo, Silvia, additional, Ciccone, Nadia, additional, Santoro, Lidia, additional, Cambò, Benedetta, additional, Iaccarino, Salvatore, additional, Dargenio, Michela, additional, Aprile, Lara, additional, Chiaretti, Sabina, additional, Fanin, Renato, additional, Pizzolo, Giovanni, additional, and Foà, Roberto, additional

Published
2020
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48. Epidemiology and clinical outcomes of latent tuberculosis infection in adults affected with acute leukemia or aplastic anemia: a retrospective single-center study

Author

Bettelli, Francesca, primary, Giusti, Davide, additional, Morselli, Monica, additional, Colaci, Elisabetta, additional, Nasillo, Vincenzo, additional, Pioli, Valeria, additional, Gilioli, Andrea, additional, Iotti, Silvia, additional, Galassi, Laura, additional, Giubbolini, Rachele, additional, Colasante, Corrado, additional, Catellani, Hillary, additional, Barozzi, Patrizia, additional, Lagreca, Ivana, additional, Vallerini, Daniela, additional, Maffei, Rossana, additional, Franceschini, Erica, additional, Mussini, Cristina, additional, Banchelli, Federico, additional, D’Amico, Roberto, additional, Marasca, Roberto, additional, Narni, Franco, additional, Potenza, Leonardo, additional, Comoli, Patrizia, additional, Luppi, Mario, additional, and Forghieri, Fabio, additional

Published
2020
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50. Severe pneumonia caused by Legionella pneumophila serogroup 11, Italy

Author

Grottola, Antonella, Forghieri, Fabio, Meacci, Marisa, Fabio, Anna, Pozzi, Lorena, Marchegiano, Patrizia, Codeluppi, Mauro, Morselli, Monica, Potenza, Leonardo, Paolini, Ambra, Coluccio, Valeria, Luppi, Mario, Rumpianesi, Fabio, and Pecorari, Monica

Subjects
Diagnosis, Usage, Research, Genetic aspects, Risk factors, Health aspects, Anti-infective agents -- Usage -- Health aspects, Pneumonia -- Risk factors, Legionella pneumophila -- Research -- Genetic aspects -- Diagnosis, Bacterial pneumonia -- Risk factors
Abstract

To the Editor: Legionella pneumophila serogroups (SGs) 1-16 cause pneumonia in humans. Although SG 1 is the serogroup most commonly associated with disease (1), we report a case of community-acquired [...]

Published
2012

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