Search

Your search keyword '"Fuentealba, Matias"' showing total 13 results
Start Over Author "Fuentealba, Matias" Search Limiters Available in Library Collection
13 results on '"Fuentealba, Matias"'

1. Association of biological aging with frailty and post-transplant outcomes among adults with cirrhosis

Author

LaHue, Sara C, Fuentealba, Matias, Roa Diaz, Stephanie, Seetharaman, Srilakshmi, Garcia, Thelma, Furman, David, Lai, Jennifer C, and Newman, John C

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Clinical Research, Transplantation, Organ Transplantation, Aging, Digestive Diseases, Liver Disease, Genetics, Chronic Liver Disease and Cirrhosis, Good Health and Well Being, Humans, Aged, Frailty, Leukocytes, Mononuclear, Liver Cirrhosis, Biological age, Epigenetic clock, Cirrhosis, Clinical sciences
Abstract

Frailty is classically associated with advanced age but is also an important predictor of clinical outcomes in comparatively young adults with cirrhosis. We examined the association of biological aging with frailty and post-transplant outcomes in a pilot of adults with cirrhosis undergoing liver transplantation (LT). Frailty was measured via the Liver Frailty Index (LFI). The primary epigenetic clock DNA methylation (DNAm) PhenoAge was calculated from banked peripheral blood mononuclear cells; we secondarily explored two first-generation clocks (Hannum; Horvath) and two additional second-generation clocks (GrimAge; GrimAge2). Twelve adults were included: seven frail (LFI ≥ 4.4, mean age 55 years) and five robust (LFI

Published
2024

2. Author Correction: To boldly go where no microRNAs have gone before: spaceflight impact on risk for small-for-gestational-age infants

Author

Corti, Giada, Kim, JangKeun, Enguita, Francisco J., Guarnieri, Joseph W., Grossman, Lawrence I., Costes, Sylvain V., Fuentealba, Matias, Scott, Ryan T., Magrini, Andrea, Sanders, Lauren M., Singh, Kanhaiya, Sen, Chandan K., Juran, Cassandra M., Paul, Amber M., Furman, David, Calleja-Agius, Jean, Mason, Christopher E., Galeano, Diego, Bottini, Massimo, and Beheshti, Afshin

Published
2024
Full Text
View/download PDF

3. To boldly go where no microRNAs have gone before: spaceflight impact on risk for small-for-gestational-age infants

Author

Corti, Giada, Kim, JangKeun, Enguita, Francisco J., Guarnieri, Joseph W., Grossman, Lawrence I., Costes, Sylvain V., Fuentealba, Matias, Scott, Ryan T., Magrini, Andrea, Sanders, Lauren M., Singh, Kanhaiya, Sen, Chandan K., Juran, Cassandra M., Paul, Amber M., Furman, David, Calleja-Agius, Jean, Mason, Christopher E., Galeano, Diego, Bottini, Massimo, and Beheshti, Afshin

Published
2024
Full Text
View/download PDF

4. Single-cell analysis identifies conserved features of immune dysfunction in simulated microgravity and spaceflight

Author

Wu, Fei, Du, Huixun, Overbey, Eliah, Kim, JangKeun, Makhijani, Priya, Martin, Nicolas, Lerner, Chad A., Nguyen, Khiem, Baechle, Jordan, Valentino, Taylor R., Fuentealba, Matias, Bartleson, Juliet M., Halaweh, Heather, Winer, Shawn, Meydan, Cem, Garrett-Bakelman, Francine, Sayed, Nazish, Melov, Simon, Muratani, Masafumi, Gerencser, Akos A., Kasler, Herbert G., Beheshti, Afshin, Mason, Christopher E., Furman, David, and Winer, Daniel A.

Published
2024
Full Text
View/download PDF

5. Single-cell multi-ome and immune profiles of the Inspiration4 crew reveal conserved, cell-type, and sex-specific responses to spaceflight

Author

Kim, JangKeun, Tierney, Braden T., Overbey, Eliah G., Dantas, Ezequiel, Fuentealba, Matias, Park, Jiwoon, Narayanan, S. Anand, Wu, Fei, Najjar, Deena, Chin, Christopher R., Meydan, Cem, Loy, Conor, Mathyk, Begum, Klotz, Remi, Ortiz, Veronica, Nguyen, Khiem, Ryon, Krista A., Damle, Namita, Houerbi, Nadia, Patras, Laura I., Schanzer, Nathan, Hutchinson, Gwyneth A., Foox, Jonathan, Bhattacharya, Chandrima, Mackay, Matthew, Afshin, Evan E., Hirschberg, Jeremy Wain, Kleinman, Ashley S., Schmidt, Julian C., Schmidt, Caleb M., Schmidt, Michael A., Beheshti, Afshin, Matei, Irina, Lyden, David, Mullane, Sean, Asadi, Amran, Lenz, Joan S., Mzava, Omary, Yu, Min, Ganesan, Saravanan, De Vlaminck, Iwijn, Melnick, Ari M., Barisic, Darko, Winer, Daniel A., Zwart, Sara R., Crucian, Brian E., Smith, Scott M., Mateus, Jaime, Furman, David, and Mason, Christopher E.

Published
2024
Full Text
View/download PDF

6. Unfolded protein response IRE1/XBP1 signaling is required for healthy mammalian brain aging

Author

Cabral‐Miranda, Felipe, Tamburini, Giovanni, Martinez, Gabriela, Ardiles, Alvaro O, Medinas, Danilo B, Gerakis, Yannis, Hung, Mei‐Li Diaz, Vidal, René, Fuentealba, Matias, Miedema, Tim, Duran‐Aniotz, Claudia, Diaz, Javier, Ibaceta‐Gonzalez, Cristobal, Sabusap, Carleen M, Bermedo‐Garcia, Francisca, Mujica, Paula, Adamson, Stuart, Vitangcol, Kaitlyn, Huerta, Hernan, Zhang, Xu, Nakamura, Tomohiro, Sardi, Sergio Pablo, Lipton, Stuart A, Kennedy, Brian K, Henriquez, Juan Pablo, Cárdenas, J Cesar, Plate, Lars, Palacios, Adrian G, and Hetz, Claudio

Subjects
Biochemistry and Cell Biology, Biomedical and Clinical Sciences, Biological Sciences, Genetics, Brain Disorders, Aging, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Behavioral and Social Science, Neurosciences, Dementia, Alzheimer's Disease, Neurodegenerative, Acquired Cognitive Impairment, Basic Behavioral and Social Science, 2.1 Biological and endogenous factors, 1.1 Normal biological development and functioning, Neurological, Animals, Mice, Brain, Endoplasmic Reticulum Stress, Protein Serine-Threonine Kinases, Proteomics, Signal Transduction, Unfolded Protein Response, X-Box Binding Protein 1, aging brain, ER stress, proteostasis, UPR, XBP1s, Information and Computing Sciences, Medical and Health Sciences, Developmental Biology, Biological sciences, Biomedical and clinical sciences
Abstract

Aging is a major risk factor to develop neurodegenerative diseases and is associated with decreased buffering capacity of the proteostasis network. We investigated the significance of the unfolded protein response (UPR), a major signaling pathway activated to cope with endoplasmic reticulum (ER) stress, in the functional deterioration of the mammalian brain during aging. We report that genetic disruption of the ER stress sensor IRE1 accelerated age-related cognitive decline. In mouse models, overexpressing an active form of the UPR transcription factor XBP1 restored synaptic and cognitive function, in addition to reducing cell senescence. Proteomic profiling of hippocampal tissue showed that XBP1 expression significantly restore changes associated with aging, including factors involved in synaptic function and pathways linked to neurodegenerative diseases. The genes modified by XBP1 in the aged hippocampus where also altered. Collectively, our results demonstrate that strategies to manipulate the UPR in mammals may help sustain healthy brain aging.

Published
2022

7. The unfolded protein response transcription factor XBP1s ameliorates Alzheimer’s disease by improving synaptic function and proteostasis

Author

Duran-Aniotz, Claudia, Poblete, Natalia, Rivera-Krstulovic, Catalina, Ardiles, Álvaro O., Díaz-Hung, Mei Li, Tamburini, Giovanni, Sabusap, Carleen Mae P., Gerakis, Yannis, Cabral-Miranda, Felipe, Diaz, Javier, Fuentealba, Matias, Arriagada, Diego, Muñoz, Ernesto, Espinoza, Sandra, Martinez, Gabriela, Quiroz, Gabriel, Sardi, Pablo, Medinas, Danilo B., Contreras, Darwin, Piña, Ricardo, Lourenco, Mychael V., Ribeiro, Felipe C., Ferreira, Sergio T., Rozas, Carlos, Morales, Bernardo, Plate, Lars, Gonzalez-Billault, Christian, Palacios, Adrian G., and Hetz, Claudio

Published
2023
Full Text
View/download PDF

9. Simultaneous neuronal expression of human amyloid-β and Tau genes drives global phenotypic and multi-omic changes in C. elegans

Author

Holcom, Angelina, Fuentealba, Matias, Sivapatham, Renuka, King, Christina D., Osman, Hadley, Foulger, Anna, Bhaumik, Dipa, Schilling, Birgit, Furman, David, Andersen, Julie K., and Lithgow, Gordon J.

Subjects
Article
Abstract

Alzheimer’s disease and Alzheimer’s related diseases (ADRD) are a class of prevalent age-related neurodegenerative disorders characterized by the accumulation of amyloid- β (Aβ) plaques and Tau neurofibrillary tangles. The intricate interplay between Aβ and Tau proteins requires further investigation to better understand the precise mechanisms underlying disease pathology. The nematode Caenorhabditis elegans ( C. elegans ) serves as an invaluable model organism for studying aging and neurodegenerative diseases. Here we performed an unbiased systems analysis of a C. elegans strain expressing both Aβ and Tau proteins within neurons. Intriguingly, even at an early stage of adulthood, we observed reproductive impairments and mitochondrial dysfunction consistent with substantial disruptions in mRNA transcript abundance, protein solubility, and metabolite levels. Notably, the simultaneous expression of these two neurotoxic proteins exhibited a synergistic effect, leading to accelerated aging in the model organism. Our comprehensive findings shed new light on the intricate relationship between normal aging processes and the etiology of ADRD. Specifically, we demonstrate the alterations to metabolic functions precede age-related neurotoxicity, offering critical insights into potential therapeutic strategies.

Published
2023

10. Unfolded protein response IRE1 / XBP1 signaling is required for healthy mammalian brain aging

Author

Cabral‐Miranda, Felipe, primary, Tamburini, Giovanni, additional, Martinez, Gabriela, additional, Ardiles, Alvaro O, additional, Medinas, Danilo B, additional, Gerakis, Yannis, additional, Hung, Mei‐Li Diaz, additional, Vidal, René, additional, Fuentealba, Matias, additional, Miedema, Tim, additional, Duran‐Aniotz, Claudia, additional, Diaz, Javier, additional, Ibaceta‐Gonzalez, Cristobal, additional, Sabusap, Carleen M, additional, Bermedo‐Garcia, Francisca, additional, Mujica, Paula, additional, Adamson, Stuart, additional, Vitangcol, Kaitlyn, additional, Huerta, Hernan, additional, Zhang, Xu, additional, Nakamura, Tomohiro, additional, Sardi, Sergio Pablo, additional, Lipton, Stuart A, additional, Kennedy, Brian K, additional, Henriquez, Juan Pablo, additional, Cárdenas, J Cesar, additional, Plate, Lars, additional, Palacios, Adrian G, additional, and Hetz, Claudio, additional

Published
2022
Full Text
View/download PDF

11. Unfolded protein response IRE1/XBP1 signaling is required for healthy mammalian brain aging.

Author

Cabral-Miranda, Felipe, Cabral-Miranda, Felipe, Tamburini, Giovanni, Martinez, Gabriela, Ardiles, Alvaro, Medinas, Danilo, Gerakis, Yannis, Hung, Mei-Li, Vidal, René, Fuentealba, Matias, Miedema, Tim, Duran-Aniotz, Claudia, Diaz, Javier, Ibaceta-Gonzalez, Cristobal, Sabusap, Carleen, Bermedo-Garcia, Francisca, Mujica, Paula, Adamson, Stuart, Vitangcol, Kaitlyn, Huerta, Hernan, Zhang, Xu, Nakamura, Tomohiro, Sardi, Sergio, Kennedy, Brian, Henriquez, Juan, Cárdenas, J, Plate, Lars, Palacios, Adrian, Hetz, Claudio, Lipton, Stuart, Cabral-Miranda, Felipe, Cabral-Miranda, Felipe, Tamburini, Giovanni, Martinez, Gabriela, Ardiles, Alvaro, Medinas, Danilo, Gerakis, Yannis, Hung, Mei-Li, Vidal, René, Fuentealba, Matias, Miedema, Tim, Duran-Aniotz, Claudia, Diaz, Javier, Ibaceta-Gonzalez, Cristobal, Sabusap, Carleen, Bermedo-Garcia, Francisca, Mujica, Paula, Adamson, Stuart, Vitangcol, Kaitlyn, Huerta, Hernan, Zhang, Xu, Nakamura, Tomohiro, Sardi, Sergio, Kennedy, Brian, Henriquez, Juan, Cárdenas, J, Plate, Lars, Palacios, Adrian, Hetz, Claudio, and Lipton, Stuart

Abstract

Aging is a major risk factor to develop neurodegenerative diseases and is associated with decreased buffering capacity of the proteostasis network. We investigated the significance of the unfolded protein response (UPR), a major signaling pathway activated to cope with endoplasmic reticulum (ER) stress, in the functional deterioration of the mammalian brain during aging. We report that genetic disruption of the ER stress sensor IRE1 accelerated age-related cognitive decline. In mouse models, overexpressing an active form of the UPR transcription factor XBP1 restored synaptic and cognitive function, in addition to reducing cell senescence. Proteomic profiling of hippocampal tissue showed that XBP1 expression significantly restore changes associated with aging, including factors involved in synaptic function and pathways linked to neurodegenerative diseases. The genes modified by XBP1 in the aged hippocampus where also altered. Collectively, our results demonstrate that strategies to manipulate the UPR in mammals may help sustain healthy brain aging.

Published
2022

13. Neuronal expression of human amyloid-β and Tau drives global phenotypic and multi-omic changes in C. elegans .

Author

Holcom A, Fuentealba M, Sivapatham R, King CD, Osman H, Foulger A, Bhaumik D, Schilling B, Furman D, Andersen JK, and Lithgow GJ

Abstract

Alzheimer's disease (AD) and Alzheimer's related diseases (ADRD) are prevalent age-related neurodegenerative disorders characterized by the accumulation of amyloid-β (Aβ) plaques and Tau neurofibrillary tangles. The nematode Caenorhabditis elegan s ( C. elegans ) serves as an invaluable model organism in diseases of old age-due to its rapid aging. Here we performed an unbiased systems analysis of a C. elegans strain expressing both Aβ and Tau proteins within neurons. We set out to determine if there was a phenotypic interaction between Aβ and Tau. In addition, we were interested in determining the temporal order of the phenotypic and multi-omic (geromic) outcomes. At an early stage of adulthood, we observed reproductive impairments and mitochondrial dysfunction consistent with disruptions in mRNA transcript abundance, protein solubility, and metabolite levels. Notably, the expression of these neurotoxic proteins exhibited a synergistic effect, leading to accelerated aging. Our findings shed light on the close relationship between normal aging and ADRD. Specifically, we demonstrate alterations to metabolic functions preceding age-related neurotoxicity, offering a resource for the development of new therapeutic strategies.

Published
2024
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results