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3. Transarterial Chemoembolization Combined with Tyrosine Kinase Inhibitors Plus Immune Checkpoint Inhibitors for Advanced Hepatocellular Carcinoma: A Propensity Score Matching Analysis

Author

Gao, Benjian, primary, Yang, Fengyi, additional, Zheng, Dongning, additional, Hu, Shuai, additional, Liu, Jie, additional, Liu, Hong, additional, Liu, Yongfa, additional, Liu, LinXin, additional, Wang, Rui, additional, Zhao, Yi, additional, Cui, Cheng, additional, Fang, Cheng, additional, Yang, Jin, additional, Su, Song, additional, Han, Yunwei, additional, Yang, Xiaoli, additional, and Li, Bo, additional

Published
2023
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10. Efficacy and safety of laparoscopic versus open liver resection in treatment of colorectal cancer liver metastasis: A Meta-analysis

Author

GAO Benjian

Subjects
lcsh:Diseases of the digestive system. Gastroenterology, lcsh:RC799-869
Abstract

ObjectiveTo systematically evaluate the efficacy and safety of laparoscopic liver resection (LLR) versus open liver resection (OLR) in the treatment of colorectal cancer liver metastasis (CRLM). MethodsChinese databases (CNKI, Wanfang, and VIP) and English databases (PubMed, Cochrane Library, and Embase) were searched for controlled clinical trials on LLR versus OLR in the treatment of CRLM published up to June 2019. Chinese search words were colorectal cancer liver metastasis, laparoscopic liver resection, and open liver resection, and English search words were colorectal cancer, colorectal liver metastases, laparoscopic hepatectomy, laparoscopic liver resection, open hepatectomy, and open liver resection. Quality assessment and data extraction were performed for the studies included, and RevMan5.3 software was used to perform the meta-analysis. ResultsA total of 23 studies were included, and there were 4204 patients in total, with 1558 patients in LLR group and 2646 in OLR group. The results of the meta-analysis showed that compared with the OLR group, the LLR group had significantly lower intraoperative blood loss (mean difference ［MD］=-145.48, 95% confidence interval ［CI］: -190.96 to-100.00, P＜0.001), lower transfusion rate (odds ratio ［OR］=0.41, 95%CI: 0.29-0.60, P＜0.001), lower incidence rate of postoperative complications (OR=0.55, 95%CI: 0.47-0.65, P＜0.001), and shorter length of postoperative hospital stay (MD=-2.69, 95%CI: -3.29 to -2.10, P＜0.001). There were no significant differences between the two groups in time of operation, perioperative mortality rate, R0 resection rate, 1- and 5-year overall survival rates, and disease-free survival rate (all P＞005). ConclusionLLR is safe and feasible in the treatment of CRLM and has better short-term efficacy than OLR, but more randomized controlled trials are needed for verification.

Published
2020

12. Intratumoral Administration of Thermosensitive Hydrogel Co-Loaded with Norcantharidin Nanoparticles and Doxorubicin for the Treatment of Hepatocellular Carcinoma

Author

Gao,Benjian, Luo,Jia, Liu,Ying, Su,Song, Fu,Shaozhi, Yang,Xiaoli, Li,Bo, Gao,Benjian, Luo,Jia, Liu,Ying, Su,Song, Fu,Shaozhi, Yang,Xiaoli, and Li,Bo

Abstract

Benjian Gao,1– 3,* Jia Luo,4,* Ying Liu,1– 3,* Song Su,1– 3 Shaozhi Fu,4 Xiaoli Yang,1– 3 Bo Li1– 3 1Department of General Surgery (Hepatobiliary Surgery), The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan Province, People’s Republic of China; 2Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Luzhou, Sichuan Province, People’s Republic of China; 3Academician (Expert) Workstation of Sichuan Province, Luzhou, Sichuan Province, People’s Republic of China; 4Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiaoli Yang; Bo LiDepartment of Hepatobiliary Surgery, The Affiliated Hospital of Southwest Medical University, No. 25 Taiping Road, Luzhou, Sichuan, 646000, People’s Republic of ChinaTel +86-15086878251; +86-13518371998Email 344920646@qq.com; liboer2002@126.comBackground: The efficacy of systemic chemotherapy for hepatocellular carcinoma (HCC) is predominantly hampered by low accumulation in tumor tissue and the high systemic toxicity of anticancer drugs. In this study, we designed an in situ drug-loaded injectable thermosensitive hydrogel system for the simultaneous delivery of norcantharidin-loaded nanoparticles (NCTD-NPs) and doxorubicin (Dox) via intratumoral administration to HCC tumors.Methods: NCTD-NPs were prepared by the thin film dispersion method using PCEC polymers as the carrier. Then, NCTD-NPs and Dox were co-encapsulated in a thermosensitive hydrogel based on Pluronic F127 (PF127) to construct a dual drug-loaded hydrogel system. The rheological properties of the drug-loaded hydrogel were studied using a rheometer. Drug release of the drug-loaded hydrogel and cytotoxicity in HepG2 cells were evaluated in vitro. An H22 tumor-bearing mice model was used to assess th

Published
2021

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