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4. Effect of maternal age and body mass index on induction of labor with oral misoprostol for premature rupture of membrane at term: A retrospective cross-sectional study

Author

Sfregola Gianfranco, Sfregola Pamela, Ruta Federico, Zendoli Federica, Musicco Alessandra, Garzon Simone, Uccella Stefano, Etrusco Andrea, Chiantera Vito, Terzic Sanja, Giannini Andrea, and Laganà Antonio Simone

Subjects
premature rupture of membrane, age, body mass index, labor induction, cervical ripening, oral misoprostol, Medicine
Abstract

The aim of this study was to evaluate the effect of maternal age and body mass index (BMI) on induction of labor with oral misoprostol for premature rupture of membrane (PROM) at term. We have conducted retrospective cross-sectional study, including only term (37 weeks or more of gestation) PROM in healthy nulliparous women with a negative vaginal-rectal swab for group B streptococcus, a single cephalic fetus with normal birthweight, and uneventful pregnancy that were induced after 24 h from PROM. Ninety-one patients were included. According to the multivariate logistic regression, age and BMI odds ratio (OR) for induction success were 0.795 and 0.857, respectively. The study population was divided into two groups based on age (

Published
2023
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5. Risk perception and affective state on work exhaustion in obstetrics during the COVID-19 pandemic

Author

Perlini Cinzia, Garzon Simone, Franchi Massimo, Donisi Valeria, Rimondini Michela, Bosco Mariachiara, Uccella Stefano, Cromi Antonella, Ghezzi Fabio, Ginami Maddalena, Sartori Enrico, Ciccarone Francesca, Scambia Giovanni, Del Piccolo Lidia, and Raffaelli Ricciarda

Subjects
health personnel, covid-19, obstetrics, affect, burnout, professional, Medicine
Abstract

A multicenter cross-sectional survey study involving four Italian University Hospitals was performed to test the hypothesis that negative affect and positive affect (affective dimensions) mediate the association between risk perception (perceived risk of infection and death; cognitive dimensions) and the feeling of work exhaustion (WE) among obstetrics healthcare providers (HCPs) during the Coronavirus Disease 2019 (COVID-19) pandemic. Totally, 570 obstetrics HCPs were invited to complete the 104-item IPSICO survey in May 2020. A theoretical model built on the tested hypothesis was investigated by structural equation modelling. The model explained 32.2% of the WE variance. Only negative affect mediated the association between cognitive dimensions and WE and also the association between WE and psychological well-being before the pandemic, experiences of stressful events, female gender, and dysfunctional coping. Non-mediated associations with WE were observed for work perceived as a duty, experience of stressful events, support received by colleagues, and the shift strategy. Only previous psychological well-being, support by colleagues, and shift strategies were inversely associated with WE. Based on study results, monitoring negative than positive affect appears superior in predicting WE, with practical implications for planning psychological interventions in HCPs at the individual, interpersonal, and organizational levels.

Published
2022
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6. Evaluation of menstrual irregularities after COVID-19 vaccination: Results of the MECOVAC survey

Author

Laganà Antonio Simone, Veronesi Giovanni, Ghezzi Fabio, Ferrario Marco Mario, Cromi Antonella, Bizzarri Mariano, Garzon Simone, and Cosentino Marco

Subjects
covid-19, vaccine, menstrual irregularities, abnormal uterine bleeding, adverse effect, Medicine
Abstract

We investigated menstrual irregularities after the first and second doses of the COVID-19 vaccine. Women answered a customised online questionnaire (ClinicalTrial.gov ID: NCT05083065) aimed to assess the vaccine type, the phase of the menstrual cycle during which the vaccine was administered, the occurrence of menstrual irregularities after the first and second doses, and how long this effect lasted. We excluded women with gynaecological and non-gynaecological diseases, undergoing hormonal and non-hormonal treatments, in perimenopause or menopause, as well as those who had irregular menstrual cycles in the last 12 months before vaccine administration. According to our data analysis, approximately 50–60% of reproductive-age women who received the first dose of the COVID-19 vaccine reported menstrual cycle irregularities, regardless of the type of administered vaccine. The occurrence of menstrual irregularities seems to be slightly higher (60–70%) after the second dose. Menstrual irregularities after both the first and second doses of the vaccine were found to self-resolve in approximately half the cases within two months. Based on these results, we suggest to consider these elements during the counselling of women who receive the COVID-19 vaccine, letting them know about the potential occurrence of temporary and self-limiting menstrual cycle irregularities in the subsequent month(s).

Published
2022
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9. Where Morphological and Molecular Classifications Meet: The Role of p53 Immunohistochemistry in the Prognosis of Low-Risk Endometrial Carcinoma (GLAMOUR Study)

Author

Puppo, Andrea, primary, Fraternali Orcioni, Giulio, additional, Clignon, Valentino, additional, Musizzano, Yuri, additional, Zavattero, Carla Angela, additional, Vocino Trucco, Giulia, additional, Benazzo, Giacomo Maria, additional, Vizzielli, Giuseppe, additional, Restaino, Stefano, additional, Mariuzzi, Laura, additional, Orsaria, Maria, additional, Seracchioli, Renato, additional, Raimondo, Diego, additional, Bertoldo, Linda, additional, Uccella, Stefano, additional, Caliò, Anna, additional, Vittori Antisari, Giulia, additional, Garzon, Simone, additional, Capozzi, Vito Andrea, additional, Berretta, Roberto, additional, Cosentino, Francesco, additional, Ercoli, Alfredo, additional, Ieni, Antonio, additional, Arcieri, Martina, additional, Ceccaroni, Marcello, additional, Pesci, Anna, additional, Mantovani, Giulia, additional, Bruni, Francesco, additional, Roviglione, Giovanni, additional, Zeppa, Pio, additional, Raffone, Antonio, additional, Camanni, Marco, additional, Delpiano, Elena Maria, additional, Provenza, Claudia, additional, Borghese, Martina, additional, and Migliaretti, Giuseppe, additional

Published
2024
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13. Late diagnosis of pheochromocytoma in pregnancy with poor fetal outcome

Author

Bapayeva Gauri, Terzić Milan, Togyzbayeva Karlygash, Bekenova Aigerim, Terzić Sanja, Garzon Simone, Falzone Giovanni, and Aitbayeva Botagoz

Subjects
pheochromocytoma, pregnancy, hypertension, intrauterine growth restriction, maternal-fetal outcome, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Pheochromocytomas are rare tumors producing catecholamines that could be a cause of secondary hypertension. On that basis, pheochromocytoma can occur as an extremely rare cause of hypertension in pregnancy and if diagnosed late can lead to adverse maternal-fetal outcome. In this case report we describe a case of pheochromocytoma affected pregnancy with poor fetal outcome. A 27-year-old pregnant woman was admitted for severe pre-eclampsia due to pre-gestational hypertension that was diagnosed during the first trimester. Due to high and uncontrolled maternal blood pressure and the worsened maternal-fetal condition after the admission induction of fetal lung maturity and emergency cesarean section were performed, but with poor fetal outcome. Later, an adrenal gland mass was identified using abdominal ultrasound and confirmed by computed tomography. After surgical adrenalectomy blood pressure of the patient was normalized. Pheochromocytoma should be considered as a possible cause of hypertensive disorder during pregnancy, particularly in cases of severe and unresponsive hypertension in order to provide for timely and appropriate treatment.

Published
2021

14. Association of a large vulvar tumor in a young premenopausal woman with recurrent pseudoangiomatous stromal hyperplasia of the breasts

Author

Knickerbocker Angelica M., Timmons Douglas, Tjendra Youley, Garzon Simone, and Carugno Jose

Subjects
vulva, breast, pseudoangiomatous stromal hyperplasia, immunosuppression, diagnosis, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Pseudoangiomatous stromal hyperplasia is a benign proliferative lesion of the breast tissue that typically affects women in the reproductive age. Pseudoangiomatous stromal hyperplasia usually presents as a localized, painless, firm mass or as a diffuse thickened area of the breast. Rarely, it can arise along the embryonic milk line, up to the anogenital region, where it simulates angiosarcomas. Awareness of this uncommon condition is important in order to avoid unnecessary aggressive excisional surgical procedures. For this purpose, we present a case of nodular pseudoangiomatous stromal hyperplasia arising in the vulva in a patient with recurrent pseudoangiomatous stromal hyperplasia of the breast.

Published
2020

15. Advanced bipolar vessel sealing devices vs conventional bipolar energy in minimally invasive hysterectomy: a systematic review and meta-analysis

Author

Zorzato, Pier Carlo, primary, Ferrari, Filippo Alberto, additional, Garzon, Simone, additional, Franchi, Massimo, additional, Cianci, Stefano, additional, Laganà, Antonio Simone, additional, Chiantera, Vito, additional, Casarin, Jvan, additional, Ghezzi, Fabio, additional, and Uccella, Stefano, additional

Published
2023
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17. Effect of maternal age and body mass index on induction of labor with oral misoprostol for premature rupture of membrane at term: A retrospective cross-sectional study

Author

Sfregola, Gianfranco, Sfregola, Pamela, Ruta, Federico, Zendoli, Federica, Musicco, Alessandra, Garzon, Simone, Uccella, Stefano, Etrusco, Andrea, Chiantera, Vito, Terzic, Sanja, Giannini, Andrea, Laganà, Antonio Simone, Sfregola, Gianfranco, Sfregola, Pamela, Ruta, Federico, Zendoli, Federica, Musicco, Alessandra, Garzon, Simone, Uccella, Stefano, Etrusco, Andrea, Chiantera, Vito, Terzic, Sanja, Giannini, Andrea, and Laganà, Antonio Simone

Subjects
Age, Oral misoprostol, Cervical ripening, Labor induction, Premature rupture of membrane, Settore MED/40 - Ginecologia E Ostetricia, Body Mass Index
Abstract

The aim of this study was to evaluate the effect of maternal age and body mass index (BMI) on induction of labor with oral misoprostol for premature rupture of membrane (PROM) at term. We have conducted retrospective cross-sectional study, including only term (37 weeks or more of gestation) PROM in healthy nulliparous women with a negative vaginal-rectal swab for group B streptococcus, a single cephalic fetus with normal birthweight, and uneventful pregnancy that were induced after 24 h from PROM. Ninety-one patients were included. According to the multivariate logistic regression, age and BMI odds ratio (OR) for induction success were 0.795 and 0.857, respectively. The study population was divided into two groups based on age (

Published
2023

19. The Role of Micronutrients in Human Papillomavirus Infection, Cervical Dysplasia, and Neoplasm

Author

Ferrari, Filippo Alberto, Magni, Francesca, Bosco, Mariachiara, Biancotto, Giulia, Zorzato, Pier Carlo, Laganà, Antonio Simone, Chiantera, Vito, Raffaelli, Ricciarda, Franchi, Massimo, Uccella, Stefano, Garzon, Simone, Ferrari, Filippo Alberto, Magni, Francesca, Bosco, Mariachiara, Biancotto, Giulia, Zorzato, Pier Carlo, Laganà, Antonio Simone, Chiantera, Vito, Raffaelli, Ricciarda, Franchi, Massimo, Uccella, Stefano, and Garzon, Simone

Subjects
Human papillomaviru, Micronutrients, Cervical cancer, Settore MED/40 - Ginecologia E Ostetricia, Cervical dysplasia, Cancer prevention
Abstract

There is evidence that diet and nutrition are modifiable risk factors for several cancers. In recent years, attention paid to micronutrients in gynecology has increased, especially regarding Human papillomavirus (HPV) infection. We performed a review of the literature up until December 2022, aiming to clarify the effects of micronutrients, minerals, and vitamins on the history of HPV infection and the development of cervical cancer. We included studies having as their primary objective the evaluation of dietary supplements, in particular calcium; zinc; iron; selenium; carotenoids; and vitamins A, B12, C, D, E, and K. Different oligo-elements and micronutrients demonstrated a potential protective role against cervical cancer by intervening in different stages of the natural history of HPV infection, development of cervical dysplasia, and invasive disease. Healthcare providers should be aware of and incorporate the literature evidence in counseling, although the low quality of evidence provided by available studies recommends further well-designed investigations to give clear indications for clinical practice.

Published
2023

20. Feasibility and Surgical Outcomes of Hysteroscopic Myomectomy of FIGO Type 3 Myoma: A Systematic Review

Author

Etrusco, Andrea, primary, Laganà, Antonio Simone, additional, Chiantera, Vito, additional, Vitagliano, Amerigo, additional, Cicinelli, Ettore, additional, Mikuš, Mislav, additional, Šprem Goldštajn, Marina Šprem, additional, Ferrari, Federico, additional, Uccella, Stefano, additional, Garzon, Simone, additional, Gerli, Sandro, additional, and Favilli, Alessandro, additional

Published
2023
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22. COVID-19 and Pregnancy: An Updated Review about Evidence-Based Therapeutic Strategies

Author

Favilli, Alessandro, primary, Mattei Gentili, Marta, additional, De Paola, Francesca, additional, Laganà, Antonio Simone, additional, Vitagliano, Amerigo, additional, Bosco, Mariachiara, additional, Cicinelli, Ettore, additional, Chiantera, Vito, additional, Uccella, Stefano, additional, Parazzini, Fabio, additional, Gerli, Sandro, additional, and Garzon, Simone, additional

Published
2023
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23. The Role of Micronutrients in Human Papillomavirus Infection, Cervical Dysplasia, and Neoplasm

Author

Ferrari, Filippo Alberto, primary, Magni, Francesca, additional, Bosco, Mariachiara, additional, Biancotto, Giulia, additional, Zorzato, Pier Carlo, additional, Laganà, Antonio Simone, additional, Chiantera, Vito, additional, Raffaelli, Ricciarda, additional, Franchi, Massimo, additional, Uccella, Stefano, additional, and Garzon, Simone, additional

Published
2023
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28. Reproductive outcomes after laparoscopic surgery in infertile women affected by ovarian endometriomas, with or without in vitro fertilisation

Author

Ban Frangež, Helena, Vrtačnik-Bokal, Eda, Štimpfel, Martin, Divjak Budihna, Teja, Gulino, Ferdinando Antonio, Garzon, Simone, Ghezzi, Fabio, Alkatout, Ibrahim, Gitas, Georgios, and Laganà, Antonio Simone

Subjects
endometriosis, reproductive outcomes, ginekologija, laparoskopska kirurgija, endometrioza, in vitro fertilisation, udc:618.1, laparoscopic surgery, neplodnost
Abstract

We performed a retrospective cohort study, namely “Surgery and ART for Endometriomas” (SAFE) trial (Clinical Trial ID: NCT03717870), including women who underwent laparoscopic cystectomy for endometrioma before first IVF and compared their reproductive outcomes with the ones of women without endometriosis and with unexplained infertility, tubal factor or male factor infertility. We found that women who underwent previous laparoscopic cystectomy for endometrioma had higher FSH and LH levels between the 2nd and 5th day of the cycle before IVF, required higher doses of gonadotrophins for ovarian stimulation and had a lower number of retrieved oocytes compared with other types of infertility. Nevertheless, pregnancy and delivery rates remain comparable to other causes of infertility. In addition, differences in ovarian stimulation parameters between endometriosis and other types of infertility lost significance with the increase of women’s age. These pieces of information can be considered useful to make adequate counselling about reproductive outcomes for infertile women with ovarian endometriomas and allow a proper decision-making approach shared with the patient.

Published
2022

29. Conservative Management of Atypical Endometrial Hyperplasia and Early Endometrial Cancer in Childbearing Age Women

Author

Uccella, Stefano, primary, Zorzato, Pier Carlo, additional, Dababou, Susan, additional, Bosco, Mariachiara, additional, Torella, Marco, additional, Braga, Andrea, additional, Frigerio, Matteo, additional, Gardella, Barbara, additional, Cianci, Stefano, additional, Laganà, Antonio Simone, additional, Franchi, Massimo Piergiuseppe, additional, and Garzon, Simone, additional

Published
2022
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30. Clinical Manifestation and Obstetric Outcomes in Pregnant Women with SARS-CoV-2 Infection at Delivery: A Retrospective Cohort Analysis

Author

Grgić, Gordana, primary, Cerovac, Anis, additional, Hudić, Igor, additional, Laganà, Antonio Simone, additional, Favilli, Alessandro, additional, Garzon, Simone, additional, Chiantera, Vito, additional, Margioula-Siarkou, Chrysoula, additional, Hadžimehmedović, Azra, additional, and Mandžić, Amer, additional

Published
2022
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31. Isolated tumour cells in a sentinel lymph node of apparent early-stage ovarian cancer: Ultrastaging of all other 27 lymph nodes

Author

Uccella, Stefano, primary, Bosco, Mariachiara, additional, Fagotti, Anna, additional, Garzon, Simone, additional, Zorzato, Pier Carlo, additional, Tinelli, Raffaele, additional, Biletta, Elena, additional, Porcari, Irene, additional, Liscia, Daniele, additional, Scambia, Giovanni, additional, and Franchi, Massimo, additional

Published
2022
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33. Health systems analysis and evaluation of the barriers to availability, utilisation and readiness of sexual and reproductive health services in COVID-19-affected areas: a WHO mixed-methods study protocol

Author

Kouanda, Seni, Nahyuha Chomi, Eunice, Kim, Caron, Jen, Sothornwit, Bahamondes, Luis, Cecatti, Jose Guilherme, Lumbiganon, Pisake, Emefa, Modey, Brizuela, Vanessa, Kuganantham, Hamsadvani, Seuc, Armando Humberto, Ali, Moazzam, Luis, Bahamondes, Jose Guilherme Cecatti, Eunice, Chomi, Seni, Kouanda, Kun, Tang, Hanxiyue, Zhang, Yifan, Zhu, Yueping, Guo, Yang, Ge, Chunxiao, Peng, Deda Ogum Alangea, Kwasi, Tropsey, Emefa Judith Modey, Rozina, Karmaliani, Laila, Ladak, Pisake, Lumbiganon, Marleen, Temmerman, Abdu, Mohiddin, Ferdinand, Okwaro, Mirandola, Massimo, Cordioli, Maddalena, Savoldi, Alessia, Garzon, Simone, Uccella, Stefano, Poli, Ranieri, Nigel, Sherriff, Alexandra, Sawyer, Jorg, Huber, Jaime, Vera, Debbie, Williams, Moazzam, Ali, Caron, Kim, Hamsadvani, Kuganantham, Igor, Toskin, Vanessa, Brizuela, Anna, Thorson, Joy Jerop Chebet, Hugo Gamerro Abrego, Soe Soe Thwin, and Armando, Seuc

Subjects
Systems Analysis, COVID19, public health, Social Sciences, COVID-19, General Medicine, World Health Organization, Cross-Sectional Studies, Pregnancy, Medicine and Health Sciences, Humans, Female, Reproductive Health Services, Pandemics, reproductive medicine
Abstract

IntroductionCOVID-19 has led to an unprecedented increase in demand on health systems to care for people infected, necessitating the allocation of significant resources, especially medical resources, towards the response. This, compounded by the restrictions on movement instituted may have led to disruptions in the provision of essential services, including sexual and reproductive health (SRH) services. This study aims to assess the availability of contraception, comprehensive abortion care, sexually transmitted infection prevention and treatment and sexual and gender-based violence care and support services in local health facilities during COVID-19 pandemic. This is a standardised generic protocol designed for use across different global settings.Methods and analysisThis study adopts both quantitative and qualitative methods to assess health facilities’ SRH service availability and readiness, and clients’ and providers’ perceptions of the availability and readiness of these services in COVID-19-affected areas. The study has two levels: (1) perceptions of clients (and the partners) and healthcare providers, using qualitative methods, and (2) assessment of infrastructure availability and readiness to provide SRH services through reviews, facility service statistics for clients and a qualitative survey for healthcare provider perspectives. The health system assessment will use a cross-sectional panel survey design with two data collection points to capture changes in SRH services availability as a result of the COVID-19 epidemic. Data will be collected using focus group discussions, in-depth interviews and a health facility assessment survey.Ethics and disseminationEthical approval for this study was obtained from the WHO Scientific and Ethics Review Committee (protocol ID CERC.0103). Each study site is required to obtain the necessary ethical and regulatory approvals that are required in each specific country.

Published
2022

35. Conventional Laparoscopy versus Robotic-Assisted Aortic Lymph-Nodal Staging for Locally Advanced Cervical Cancer: A Systematic Review and Meta-Analysis

Author

Di Donna, Mariano Catello, primary, Giallombardo, Vincenzo, additional, Lo Balbo, Giuseppina, additional, Cucinella, Giuseppe, additional, Sozzi, Giulio, additional, Capozzi, Vito Andrea, additional, Abbate, Antonino, additional, Laganà, Antonio Simone, additional, Garzon, Simone, additional, and Chiantera, Vito, additional

Published
2022
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36. Uterine Septum with or without Hysteroscopic Metroplasty: Impact on Fertility and Obstetrical Outcomes—A Systematic Review and Meta-Analysis of Observational Research

Author

Noventa, Marco, primary, Spagnol, Giulia, additional, Marchetti, Matteo, additional, Saccardi, Carlo, additional, Bonaldo, Giulio, additional, Laganà, Antonio Simone, additional, Cavallin, Francesco, additional, Andrisani, Alessandra, additional, Ambrosini, Guido, additional, Vitale, Salvatore Giovanni, additional, Pacheco, Luis Alonso, additional, Haimovich, Sergio, additional, Di Spiezio Sardo, Attilio, additional, Carugno, Jose, additional, Scioscia, Marco, additional, Garzon, Simone, additional, Bettocchi, Stefano, additional, Buzzaccarini, Giovanni, additional, Tozzi, Roberto, additional, and Vitagliano, Amerigo, additional

Published
2022
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38. Gestione operatoria

Author

Franchi, Massimo and Garzon, Simone

Subjects
Gestione operatoria
Published
2022

41. La patogenesi dell’endometriosi

Author

Antonio Simone Laganà, Garzon, Simone, Franchi, Massimo Piergiuseppe, and Fabio, Ghezzi

Subjects
pathogenesis, Endometriosis
Published
2021

42. The Psychological Impact of COVID-19 on Healthcare Providers in Obstetrics: A Cross-Sectional Survey Study

Author

Del Piccolo, Lidia, primary, Donisi, Valeria, additional, Raffaelli, Ricciarda, additional, Garzon, Simone, additional, Perlini, Cinzia, additional, Rimondini, Michela, additional, Uccella, Stefano, additional, Cromi, Antonella, additional, Ghezzi, Fabio, additional, Ginami, Maddalena, additional, Sartori, Enrico, additional, Ciccarone, Francesca, additional, Scambia, Giovanni, additional, and Franchi, Massimo, additional

Published
2021
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