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1. Rationale and Design of the Diet, CKD, and Apolipoprotein L1 Study in Low-Income and Middle-Income Countries

Author

Ilori, Titilayo O, Solarin, Adaobi, Manmak, Mamven, Raji, Yemi R, Braimoh, Rotimi, Kwakyi, Edward, Umeizudike, Theophilus, Ajepe, Titilope, Bolanle, Omotoso, Ripiye, Nanna, Eduful, Ernestina, Adebile, Temitayo, Ijeoma, Chinwuba, Mumuni, Amisu A, Chern, Jessica, Akinpelu, Morenikeji, Ulasi, Ifeoma, Arogundade, Fatiu, Salako, Babatunde L, Gbadegesin, Rasheed, Parekh, Rulan S, Dupuis, Josée, Amira, Christiana O, Adu, Dwomoa, Anderson, Cheryl AM, Ojo, Akinlolu, and Waikar, Sushrut S

Subjects
Clinical Research, Nutrition, Kidney Disease, Clinical Trials and Supportive Activities, Prevention, Good Health and Well Being, 24hr-urine potassium & sodium, Africa, engagement, retention
Abstract

IntroductionDiet, chronic kidney disease (CKD), and Apolipoprotein L1 (APOL1) (DCA) Study is examining the role of dietary factors in CKD progression and APOL1 nephropathy. We describe enrollment and retention efforts and highlight facilitators and barriers to enrollment and operational challenges, as well as accommodations made in the study protocol.MethodsThe DCA study is enrolling participants in 7 centers in West Africa. Participants who consented were invited to complete dietary recalls and 24-hour urine collections in year 1. We conducted focus groups and semistructured interviews among study personnel to identify facilitators and barriers to enrollment as well as retention and operational challenges in the execution of the study protocol. We analyzed emerging themes using content analyses.ResultsA total of 712 participants were enrolled in 18 months with 1256 24-hour urine and 1260 dietary recalls. Barriers to enrollment were the following: (i) a lack of understanding of research, (ii) the burden of research visits, and (iii) incorporating cultural and traditional nuances when designing research protocols. Factors facilitating enrollment were the following: (i) designing convenient research visits, (ii) building rapport and increased communication between the research team and participants, and (iii) cultural sensitivity - adapting research protocols for the populations involved. Offering home visits, providing free dietary counseling, reducing the volume of study blood collection, and reducing the frequency of visits were some changes made in the study protocol that increased participant satisfaction.ConclusionAdopting a participant-centered approach with accommodations in the protocol for cultural adaptability and incorporating participant feedback is vital for carrying out research in low-income and middle-income regions.

Published
2023

2. Strong protective effect of the APOL1 p.N264K variant against G2-associated focal segmental glomerulosclerosis and kidney disease

Author

Gupta, Yask, Friedman, David J., McNulty, Michelle T., Khan, Atlas, Lane, Brandon, Wang, Chen, Ke, Juntao, Jin, Gina, Wooden, Benjamin, Knob, Andrea L., Lim, Tze Y., Appel, Gerald B., Huggins, Kinsie, Liu, Lili, Mitrotti, Adele, Stangl, Megan C., Bomback, Andrew, Westland, Rik, Bodria, Monica, Marasa, Maddalena, Shang, Ning, Cohen, David J., Crew, Russell J., Morello, William, Canetta, Pietro, Radhakrishnan, Jai, Martino, Jeremiah, Liu, Qingxue, Chung, Wendy K., Espinoza, Angelica, Luo, Yuan, Wei, Wei-Qi, Feng, Qiping, Weng, Chunhua, Fang, Yilu, Kullo, Iftikhar J., Naderian, Mohammadreza, Limdi, Nita, Irvin, Marguerite R., Tiwari, Hemant, Mohan, Sumit, Rao, Maya, Dube, Geoffrey K., Chaudhary, Ninad S., Gutiérrez, Orlando M., Judd, Suzanne E., Cushman, Mary, Lange, Leslie A., Lange, Ethan M., Bivona, Daniel L., Verbitsky, Miguel, Winkler, Cheryl A., Kopp, Jeffrey B., Santoriello, Dominick, Batal, Ibrahim, Pinheiro, Sérgio Veloso Brant, Oliveira, Eduardo Araújo, Simoes e Silva, Ana Cristina, Pisani, Isabella, Fiaccadori, Enrico, Lin, Fangming, Gesualdo, Loreto, Amoroso, Antonio, Ghiggeri, Gian Marco, D’Agati, Vivette D., Magistroni, Riccardo, Kenny, Eimear E., Loos, Ruth J. F., Montini, Giovanni, Hildebrandt, Friedhelm, Paul, Dirk S., Petrovski, Slavé, Goldstein, David B., Kretzler, Matthias, Gbadegesin, Rasheed, Gharavi, Ali G., Kiryluk, Krzysztof, Sampson, Matthew G., Pollak, Martin R., and Sanna-Cherchi, Simone

Published
2023
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3. Common Risk Variants in AHI1 Are Associated With Childhood Steroid Sensitive Nephrotic Syndrome

Author

Downie, Mallory L., Gupta, Sanjana, Voinescu, Catalin, Levine, Adam P., Sadeghi-Alavijeh, Omid, Dufek-Kamperis, Stephanie, Cao, Jingjing, Christian, Martin, Kari, Jameela A., Thalgahagoda, Shenal, Ranawaka, Randula, Abeyagunawardena, Asiri, Gbadegesin, Rasheed, Parekh, Rulan, Kleta, Robert, Bockenhauer, Detlef, Stanescu, Horia C., and Gale, Daniel P.

Published
2023
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4. APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO): Design and Rationale

Author

Freedman, Barry I, Moxey-Mims, Marva M, Alexander, Amir A, Astor, Brad C, Birdwell, Kelly A, Bowden, Donald W, Bowen, Gordon, Bromberg, Jonathan, Craven, Timothy E, Dadhania, Darshana M, Divers, Jasmin, Doshi, Mona D, Eidbo, Elling, Fornoni, Alessia, Gautreaux, Michael D, Gbadegesin, Rasheed A, Gee, Patrick O, Guerra, Giselle, Hsu, Chi-yuan, Iltis, Ana S, Jefferson, Nichole, Julian, Bruce A, Klassen, David K, Koty, Patrick P, Langefeld, Carl D, Lentine, Krista L, Ma, Lijun, Mannon, Roslyn B, Menon, Madhav C, Mohan, Sumit, Moore, J Brian, Murphy, Barbara, Newell, Kenneth A, Odim, Jonah, Ortigosa-Goggins, Mariella, Palmer, Nicholette D, Park, Meyeon, Parsa, Afshin, Pastan, Stephen O, Poggio, Emilio D, Rajapakse, Nishadi, Reeves-Daniel, Amber M, Rosas, Sylvia E, Russell, Laurie P, Sawinski, Deirdre, Smith, S Carrie, Spainhour, Mitzie, Stratta, Robert J, Weir, Matthew R, Reboussin, David M, Kimmel, Paul L, and Brennan, Daniel C

Subjects
Clinical Research, Organ Transplantation, Transplantation, Kidney Disease, Renal and urogenital, Good Health and Well Being, African Americans, APOL1, chronic kidney disease, graft failure, kidney transplantation, outcomes
Abstract

IntroductionMuch of the higher risk for end-stage kidney disease (ESKD) in African American individuals relates to ancestry-specific variation in the apolipoprotein L1 gene (APOL1). Relative to kidneys from European American deceased-donors, kidneys from African American deceased-donors have shorter allograft survival and African American living-kidney donors more often develop ESKD. The National Institutes of Health (NIH)-sponsored APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO) is prospectively assessing kidney allograft survival from donors with recent African ancestry based on donor and recipient APOL1 genotypes.MethodsAPOLLO will evaluate outcomes from 2614 deceased kidney donor-recipient pairs, as well as additional living-kidney donor-recipient pairs and unpaired deceased-donor kidneys.ResultsThe United Network for Organ Sharing (UNOS), Association of Organ Procurement Organizations, American Society of Transplantation, American Society for Histocompatibility and Immunogenetics, and nearly all U.S. kidney transplant programs, organ procurement organizations (OPOs), and histocompatibility laboratories are participating in this observational study. APOLLO employs a central institutional review board (cIRB) and maintains voluntary partnerships with OPOs and histocompatibility laboratories. A Community Advisory Council composed of African American individuals with a personal or family history of kidney disease has advised the NIH Project Office and Steering Committee since inception. UNOS is providing data for outcome analyses.ConclusionThis article describes unique aspects of the protocol, design, and performance of APOLLO. Results will guide use of APOL1 genotypic data to improve the assessment of quality in deceased-donor kidneys and could increase numbers of transplanted kidneys, reduce rates of discard, and improve the safety of living-kidney donation.

Published
2020

5. Cardiovascular Risk Factor Burden and Association With CKD in Ghana and Nigeria

Author

Olanrewaju, Timothy O., Osafo, Charlotte, Raji, Yemi R., Mamven, Manmak, Ajayi, Samuel, Ilori, Titilayo O., Arogundade, Fatiu A., Ulasi, Ifeoma I., Gbadegesin, Rasheed, Parekh, Rulan S., Tayo, Bamidele, Adeyemo, Adebowale A., Adedoyin, Olanrewaju T., Chijioke, Adindu A., Bewaji, Clement, Grobbee, Diederick E., Blankestijn, Peter J., Klipstein-Grobusch, Kerstin, Salako, Babatunde L., Adu, Dwomoa, and Ojo, Akinlolu O.

Published
2023
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7. Rapid Progression of Focal Segmental Glomerulosclerosis in Patients with High-Risk APOL1 Genotypes

Author

Kallash, Mahmoud, Wang, Yujie, Smith, Abigail, Trachtman, Howard, Gbadegesin, Rasheed, Nester, Carla, Canetta, Pietro, Wang, Chen, Hunley, Tracy E., Sperati, C. John, Selewski, David, Ayoub, Isabelle, Srivastava, Tarak, Mottl, Amy K., Kopp, Jeffrey, Gillespie, Brenda, Robinson, Bruce, Chen, Dhruti, Steinke, Julia, Twombley, Katherine, Reidy, Kimberly, Mucha, Krzysztof, Greenbaum, Larry A., Blazius, Brooke, Helmuth, Margaret, Yonatan, Peleg, Parekh, Rulan S., Hogan, Susan, Royal, Virginie, DʼAgati, Vivette, Chishti, Aftab, Falk, Ronald, Gharavi, Ali, Holzman, Lawrence, Klein, Jon, Smoyer, William, Kretzler, Matthias, Gipson, Debbie, and Kidd, Jason M.

Published
2023
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9. Rationale and design of the Nephrotic Syndrome Study Network (NEPTUNE) Match in glomerular diseases: designing the right trial for the right patient, today

Author

Trachtman, Howard, primary, Desmond, Hailey, additional, Williams, Amanda L., additional, Mariani, Laura H., additional, Eddy, Sean, additional, Ju, Wenjun, additional, Barisoni, Laura, additional, Ascani, Heather K., additional, Uhlmann, Wendy R., additional, Spino, Cathie, additional, Holzman, Lawrence B., additional, Sedor, John R., additional, Gadegbeku, Crystal, additional, Subramanian, Lalita, additional, Lienczewski, Chrysta C., additional, Manieri, Tina, additional, Roberts, Scott J., additional, Gipson, Debbie S., additional, Kretzler, Matthias, additional, Massengill, Susan, additional, Lo, Layla, additional, Dell, Katherine, additional, O’Toole, John, additional, Sedor, John, additional, Martin, Blair, additional, Macumber, Ian, additional, Sharma, Silpa, additional, Srivastava, Tarak, additional, Markus, Kelsey, additional, Sethna, Christine, additional, Vento, Suzanne, additional, Canetta, Pietro, additional, Olabisi, Opeyemi, additional, Gbadegesin, Rasheed, additional, Smith, Maurice, additional, Greenbaum, Laurence, additional, Wang, Chia-shi, additional, Yun, Emily, additional, Adler, Sharon, additional, LaPage, Janine, additional, Amarah, Amatur, additional, Itteera, Mathew, additional, Atkinson, Meredith, additional, Williams, Miahje, additional, Lieske, John, additional, Hogan, Marie, additional, Fervenza, Fernando, additional, Selewski, David, additional, Alston, Cheryl, additional, Reidy, Kim, additional, Ross, Michael, additional, Kaskel, Frederick, additional, Flynn, Patricia, additional, Malaga-Dieguez, Laura, additional, Zhdanova, Olga, additional, Pehrson, Laura Jane, additional, Miranda, Melanie, additional, Almaani, Salem, additional, Roberts, Laci, additional, Lafayette, Richard, additional, Dave, Shiktij, additional, Lee, Iris, additional, Shah, Shweta, additional, Batla, Sadaf, additional, Reich, Heather, additional, Hladunewich, Michelle, additional, Ling, Paul, additional, Romano, Martin, additional, Brakeman, Paul, additional, Dylewski, James, additional, Rogers, Nathan, additional, McCarthy, Ellen, additional, Creed, Catherine, additional, Fornoni, Alessia, additional, Bandes, Miguel, additional, Mariani, Laura, additional, Modi, Zubin, additional, Williams, A., additional, Ni, Roxy, additional, Nachman, Patrick, additional, Rheault, Michelle, additional, Kowalski, Amy, additional, Rauwolf, Nicolas, additional, Derebail, Vimal, additional, Gibson, Keisha, additional, Froment, Anne, additional, Kelley, Sara, additional, Holzman, Lawrence, additional, Meyers, Kevin, additional, Kallem, Krishna, additional, Edwards, Aliya, additional, Sharma, Samin, additional, Roehm, Elizabeth, additional, Sambandam, Kamalanathan, additional, Brown, Elizabeth, additional, Hellewege, Jamie, additional, Jefferson, Ashley, additional, Hingorani, Sangeeta, additional, Tuttle, Katherine, additional, Manahan, Linda, additional, Pao, Emily, additional, Kuykendall, Kelli, additional, Lin, Jen Jar, additional, Dharnidharka, Vikas, additional, Gillespie, Brenda, additional, Salmon, Eloise, additional, Trachtman, Howard, additional, Mainieri, Tina, additional, Alter, Gabrielle, additional, Arbit, Michael, additional, Fermin, Damian, additional, Larkina, Maria, additional, Lienczewski, Chrysta, additional, Scherr, Rebecca, additional, Troost, Jonathan, additional, Williams, Amanda, additional, Zhai, Yan, additional, Kincaid, Colleen, additional, Li, Shengqian, additional, Li, Shannon, additional, Sampson, Matthew G., additional, Smith, Abigail, additional, Zee, Jarcy, additional, Avila-Casado, Carmen, additional, Bagnasco, Serena, additional, Bu, Lihong, additional, Caltharp, Shelley, additional, Cassol, Clarissa, additional, Demeke, Dawit, additional, Hassler, Jared, additional, Herlitz, Leal, additional, Hewitt, Stephen, additional, Hodgin, Jeff, additional, Holanda, Danni, additional, Kambham, Neeraja, additional, Lemley, Kevin, additional, Messias, Nidia, additional, Mikhailov, Alexei, additional, Moreno, Vanessa, additional, Najafian, Behzad, additional, Palmer, Matthew, additional, Rosenberg, Avi, additional, Royal, Virginie, additional, Sekulik, Miroslav, additional, Stokes, Barry, additional, Thomas, David, additional, Wu, Ming, additional, Yamashita, Michifumi, additional, Yin, Hong, additional, Zuo . Cochairs, Yiqin, additional, and Nast, Cynthia, additional

Published
2024
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10. Trends in the epidemiology of childhood nephrotic syndrome in Africa: A systematic review

Author

Wine, Rachel, Vasilevska-Ristovska, Jovanka, Banh, Tonny, Knott, Janae, Noone, Damien, Gbadegesin, Rasheed, Ilori, Titilayo O., Okafor, Henrietta U., Furia, Francis, Ulasi, Ifeoma, Solarin, Adaobi U., Esezobor, Christopher, Batte, Anthony, Raji, Yemi, Olanrewaju, Timothy O., Muoneke, Uzoamaka, Adetunji, Adewale E., Boima, Vincent, Amira, Oluwatoyin, Osafo, Charlotte, Guemkam, Georgette, Ajayi, Samuel, Makusidi, Muhammad A., Anigilaje, Emmanuel A., Ruggajo, Paschal, Asinobi, Adanze O., Ademola, Adebowale D., and Parekh, Rulan S.

Published
2021
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12. Management of idiopathic childhood nephrotic syndrome in sub-Saharan Africa: Ibadan consensus statement

Author

Ashuntantang, Gloria, Georgette, Guemkam, Adu, Dwamoa, Adabayeri, Victoria May, Boima, Vincent, Osafo, Charlotte, Tannor, Elliot Koranteng, Okyere, Perditer, Antwi, Sampson, Plange-Rhule, Jacob, Mamven, Manmak, Ajayi, Samuel, Anigilaje, Emmanuel, Okoye, Ogochukwu, Okperi, Ofejiro, Ighosewe, Okiroro, Ulasi, Ifeoma, Muoneke, Uzoamaka, Odetunde, Odutola, Okafor, Henrietta U., Salako, Babatunde, Ademola, Adebowale, Amodu, Kemi, Raji, Yemi, Adanze, Asinobi O., Arogundade, Fatiu, Olowu, Wasiu, Olanrewaju, Timothy Olusegun, Adedoyin, Olanrewaju, Obiagwu, Patience, Abdu, Aliyu, Solarin, Adaobi, Amira, Oluwatoyin, Esezobor, Christopher, Odenigbo, Charles, Jisieike-Onuigbo, Nonyelum, Musa, Adesola, Audu, Rosemary, Jinadu, Olanrewaju, Adetunji, Adewale E., Makusidi, Muhammad, Jiya Bello, Fatima Nma, Awobusuyi, Jacob Olugbenga, McCulloch, Mignon, Nourse, Peter, Furia, Francis Frederick, Ruggajo, Paschal, Shoo, Jacqueline, Kalyesubula, Robert, Kansiime, Grace, Batte, Anthony, Parekh, Rulan S., Noone, Damien, Vasilevska-Ristovska, Jovanka, Banh, Tonny H.M., Ojo, Akinlolu O., Wilson, Jillian, Smith, Donna, Ilori, Titilayo, Gbadegesin, Rasheed, Ademola, Adebowale D., Anigilaje, Emmanuel A., Jiya-Bello, Fatima N., Furia, Francis F., and Tannor, Elliot K.

Published
2021
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13. Doris Duke Charitable Foundation Fund to Retain Clinical Scientists: innovating support for early-career family caregivers

Author

Jagsi, Reshma, Beeland, T. DeLene, Sia, Kevin, Szczygiel, Lauren A., Allen, Matthew R., Arora, Vineet M., Bair-Merritt, Megan, Bauman, Melissa D., Bogner, Hillary R., Daumit, Gail, Davis, Esa, Fagerlin, Angela, Ford, Daniel E., Gbadegesin, Rasheed, Griendling, Kathy, Hartmann, Katherine, Hedayati, S. Susan, Jackson, Rebecca D., Matulevicius, Susan, Mugavero, Michael J., Nehl, Eric J., Neogi, Tuhina, Regensteiner, Judith G., Rubin, Michael A., Rubio, Doris, Singer, Kanakadurga, Edmonds, Brownsyne Tucker, Volerman, Anna, Laney, Sandra, Patton, Carrie, and Alvarez, Sindy Escobar

Subjects
Medical scientists -- Finance -- Social aspects, Caregivers -- Social aspects -- Finance, Company financing, Health care industry, Doris Duke Charitable Foundation -- Donations
Abstract

Introduction The COVID-19 pandemic has highlighted and amplified family caregiving obligations for many clinical investigators and other biomedical researchers. Unpredictable access to daycare, schools, assisted living facilities, informal networks, and [...]

Published
2022
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14. Common risk variants in NPHS1 and TNFSF15 are associated with childhood steroid-sensitive nephrotic syndrome

Author

Araki, Yoshinori, Nagaoka, Yoshinobu, Okamoto, Takayuki, Sato, Yasuyuki, Hayashi, Asako, Takahashi, Toshiyuki, Aoyagi, Hayato, Ueno, Michihiko, Nakanishi, Masanori, Toita, Nariaki, Uetake, Kimiaki, Kobayashi, Norio, Fujita, Shoji, Tsuruga, Kazushi, Kumagai, Naonori, Kudo, Hiroki, Tanaka, Eriko, Omori, Tae, Okada, Mari, Hatai, Yoshiho, Udagawa, Tomohiro, Motoyoshi, Yaeko, Ishikura, Kenji, Kamei, Koichi, Ogura, Masao, Sato, Mai, Kano, Yuji, Hattori, Motoshi, Miura, Kenichiro, Harita, Yutaka, Kanda, Shoichiro, Sawanobori, Emi, Kobayashi, Anna, Kojika, Manabu, Ohwada, Yoko, Yan, Kunimasa, Hataya, Hiroshi, Hamada, Riku, Terano, Chikako, Harada, Ryoko, Hamasaki, Yuko, Hashimoto, Junya, Ito, Shuichi, Machida, Hiroyuki, Inaba, Aya, Matsuyama, Takeshi, Goto, Miwa, Shimizu, Masaki, Ohta, Kazuhide, Ikezumi, Yohei, Yamada, Takeshi, Suzuki, Toshiaki, Tamamura, Soichi, Mori, Yukiko, Hidaka, Yoshihiko, Matsuoka, Daisuke, Kinoshita, Tatsuya, Noda, Shunsuke, Kitahara, Masashi, Fujita, Naoya, Hibino, Satoshi, Iijima, Kazumoto, Nozu, Kandai, Kaito, Hiroshi, Minamikawa, Shogo, Yamamura, Tomohiko, Nagano, China, Horinouchi, Tomoko, Nakanishi, Keita, Fujimura, Junya, Sakakibara, Nana, Aoto, Yuya, Ishiko, Shinya, Tanaka, Ryojiro, Kanda, Kyoko, Inaguma, Yosuke, Hashimura, Yuya, Ishimori, Shingo, Kamiyoshi, Naohiro, Shibano, Takayuki, Takeshima, Yasuhiro, Fujimaru, Rika, Ueda, Hiroaki, Ashida, Akira, Matsumura, Hideki, Kubota, Takuo, Kitaoka, Taichi, Okuda, Yusuke, Sawai, Toshihiro, Sakai, Tomoyuki, Shima, Yuko, Hama, Taketsugu, Fujieda, Mikiya, Ishihara, Masayuki, Itoh, Shigeru, Iwaki, Takuma, Shimizu, Maki, Nagatani, Koji, Kagami, Shoji, Urushihara, Maki, Kaku, Yoshitsugu, Nishimura, Manao, Yoshino, Miwa, Hatae, Ken, Hinokiyama, Maiko, Kuroki, Rie, Ohtsuka, Yasufumi, Oka, Masafumi, Nishimura, Shinji, Sato, Tadashi, Tanaka, Seiji, Zaitsu, Ayuko, Nakazato, Hitoshi, Tamura, Hiroshi, Nakanishi, Koichi, Cho, Min Hyun, Ha, Tae-Sun, Cheong, Hae Il, Kang, Hee Gyung, Ha, Il-Soo, Kim, Ji Hyun, Park, Peong Gang, Cho, Myung Hyun, Han, Kyoung Hee, Yang, Eun Mi, Quiroga, Alejandro, Moudgil, Asha, Chavers, Blanche, Kwon, Charles, Bowers, Corinna, Gipson, Deb, Chand, Deepa, Weaver, Donald Jack, Abraham, Elizabeth, Janjua, Halima, Lin, Jen-Jar, Greenbaum, Larry, Kallash, Mahmoud, Rheault, Michelle, De Jeus Gonzalez, Nilka, Brophy, Patrick, Gbadegesin, Rasheed, Nagaraj, Shashi, Massengill, Susan, Srivastava, Tarak, Hunley, Tray, Cai, Yi, Omoloja, Abiodun, Silva, Cynthia, Adeyemo, Adebowale, Thalgahagoda, Shenal, Kari, Jameela A., El Desoky, Sherif, Abdelhadi, Mohammed, Akil, Rachida, Azib, Sonia, Basmaci, Romain, Benoist, Gregoire, Bensaid, Philippe, Blanc, Philippe, Boyer, Olivia, Bucher, Julie, Chace, Anne, Chalvon, Arnaud, Cheminee, Marion, Chendjou, Sandrine, Daoud, Patrick, Deschênes, Georges, Dossier, Claire, Elias, Ossam, Gagliadone, Chantal, Gajdos, Vincent, Galerne, Aurélien, Aigrain, Evelyne Jacqz, Sanchez, Lydie Joly, Khaled, Mohamed, Khelfaoui, Fatima, Laoudi, Yacine, Larakeb, Anis, Limani, Tarek, Mahdi, Fouad, Mandelcwaijg, Alexis, Muller, Stephanie, Nacer, Kacem, Nathanson, Sylvie, Pellegrino, Béatrice, Pharaon, Isabelle, Roudault, Véronica, Rouget, Sébastien, Saf, Marc, Simon, Tabassom, Tahiri, Cedric, Ulinski, Tim, Zenkhri, Férielle, Jia, Xiaoyuan, McNulty, Michelle T., Song, Kyuyong, Hitomi, Yuki, Lee, Dongwon, Aiba, Yoshihiro, Khor, Seik-Soon, Ueno, Kazuko, Kawai, Yosuke, Nagasaki, Masao, Noiri, Eisei, Baek, Jiwon, Abeyagunawardena, Asiri, Lane, Brandon, Chryst-Stangl, Megan, Esezobor, Christopher, Solarin, Adaobi, Vivarelli, Marina, Debiec, Hanna, Matsuo, Masafumi, Ronco, Pierre, Sampson, Matthew G., and Tokunaga, Katsushi

Published
2020
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15. Longitudinal Changes in Health-Related Quality of Life in Primary Glomerular Disease: Results From the CureGN Study

Author

Gharavi, Ali, Ahn, Wooin, Appel, Gerald B., Avasare, Rupali S., Babayev, Revekka, Batal, Ibrahim, Bomback, Andrew S., Brown, Eric, Campenot, Eric S., Canetta, Pietro, Chan, Brenda, D’Agati, Vivette D., Fernandez, Hilda, Foroncewicz, Bartosz, Ghiggeri, Gian Marco, Hines, William H., Jain, Namrata G., Kiryluk, Krzysztof, Lin, Fangming, Lugani, Francesca, Marasa, Maddalena, Markowitz, Glen, Mohan, Sumit, Mucha, Krzysztof, Nickolas, Thomas L., Radhakrishnan, Jai, Rao, Maya K., Regunathan-Shenk, Renu, Sanna-Cherchi, Simone, Santoriello, Dominick, Stokes, Michael B., Yu, Natalie, Valeri, Anthony M., Zviti, Ronald, Greenbaum, Larry A., Smoyer, William E., Al-Uzri, Amira, Ashoor, Isa, Aviles, Diego, Baracco, Rossana, Barcia, John, Bartosh, Sharon, Belsha, Craig, Braun, Michael C., Chishti, Aftab, Claes, Donna, Cramer, Carl, Davis, Keefe, Erkan, Elif, Feig, Daniel, Freundlich, Michael, Hanna, Melisha, Hidalgo, Guillermo, Jain, Amrish, Khalid, Myda, Kallash, Mahmoud, Lane, Jerome C., Mahan, John, Mathews, Nisha, Nester, Carla, Pan, Cynthia, Patel, Hiren, Revell, Adelaide, Sreedharan, Rajasree, Steinke, Julia, Wenderfer, Scott E., Wong, Craig S., Falk, Ronald, Cook, William, Derebail, Vimal, Fogo, Agnes, Gasim, Adil, Gehr, Todd, Harris, Raymond, Kidd, Jason, Laurin, Louis-Philippe, Pendergraft, Will, Pichette, Vincent, Powell, Thomas Brian, Renfrow, Matthew B., Royal, Virginie, Holzman, Lawrence B., Adler, Sharon, Alpers, Charles, Matar, Raed Bou, Brown, Elizabeth, Choi, Michael, Dell, Katherine M., Dukkipati, Ram, Fervenza, Fernando C., Fornoni, Alessia, Gadegbeku, Crystal, Gipson, Patrick, Hasely, Leah, Hingorani, Sangeeta, Hladunewich, Michelle A., Hogan, Jonathan, Jefferson, J. Ashley, Jhaveri, Kenar, Johnstone, Duncan B., Kaskel, Frederick, Kogan, Amy, Kopp, Jeffrey, Lemley, Kevin V., Dieguez, Laura Malaga, Meyers, Kevin, Neu, Alicia, O'Shaughnessy, Michelle Marie, O’Toole, John F., Parekh, Rulan, Reich, Heather, Reidy, Kimberly, Rondon, Helbert, Sambandam, Kamalanathan K., Sedor, John R., Selewski, David T., Sethna, Christine B., Schelling, Jeffrey, Sperati, John C., Swiatecka-Urban, Agnes, Trachtman, Howard, Tuttle, Katherine R., Weisstuch, Joseph, Zhdanova, Olga, Gillespie, Brenda, Gipson, Debbie S., Herreshoff, Emily, Kretzler, Matthias, Robinson, Bruce M., Mariani, Laura, Troost, Jonathan P., Wladkowski, Matthew, Guay-Woodford, Lisa M., Murphy, Shannon L., Mahan, John D., Srivastava, Tarak, Kogon, Amy J., Cai, Yi, Davis, T. Keefe, Gbadegesin, Rasheed A., Canetta, Pietro A., Nachman, Patrick H., Reeve, Bryce B., Wang, Chia-shi, and Bartosh, Sharon M.

Published
2020
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16. FSGS Recurrence Collaboration: Report of a symposium

Author

Gipson, Debbie S., primary, Wang, Chia-shi, additional, Salmon, Eloise, additional, Gbadegesin, Rasheed, additional, Naik, Abhijit, additional, Sanna-Cherchi, Simone, additional, Fornoni, Alessia, additional, Kretzler, Matthias, additional, Merscher, Sandra, additional, Hoover, Paul, additional, Kidwell, Kelley, additional, Saleem, Moin, additional, Riella, Leonardo, additional, Holzman, Lawrence, additional, Jackson, Annette, additional, Olabisi, Opeyemi, additional, Cravedi, Paolo, additional, Freedman, Benjamin Solomon, additional, Himmelfarb, Jonathan, additional, Vivarelli, Marina, additional, Harder, Jennifer, additional, Klein, Jon, additional, Burke, George, additional, Rheault, Michelle, additional, Spino, Cathie, additional, Desmond, Hailey E., additional, and Trachtman, Howard, additional

Published
2023
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18. Addressing the physician-scientist pipeline: strategies to integrate research into clinical training programs

Author

Permar, Sallie R., Ward, Rebecca A., Freel, Katherine J. Barret Stephanie A., Gbadegesin, Rasheed A., Kontos, Christopher D., Hu, Patrick J., Hartmann, Katherine E., Williams, Christopher S., and Vyas, Jatin M.

Subjects
Bridges (Structures), Physicians -- Training, Medical schools, Scientists -- Training, Therapeutics, Pipelines, Nobel laureates, Health care industry, Duke University. School of Medicine -- Training, Vanderbilt University. School of Medicine -- Training, Massachusetts General Hospital -- Training
Abstract

Introduction Physician-scientists are critical members of the biomedical workforce. The combination of rigorous scientific training and clinical skills uniquely positions them to bridge clinical needs with investigational pursuits by identifying [...]

Published
2020
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20. Enabling the genomic revolution in Africa

Author

Rotimi, Charles, Abayomi, Akin, Abimiku, Alash'le, Adabayeri, Victoria May, Adebamowo, Clement, Adebiyi, Ezekiel, Ademola, Adebowale D, Adeyemo, Adebowale, Adu, Dwomoa, Affolabi, Dissou, Agongo, Godfred, Ajayi, Samuel, Akarolo-Anthony, Sally, Akinyemi, Rufus, Akpalu, Albert, Alberts, Marianne, Alonso Betancourt, Orlando, Alzohairy, Ahmed Mansour, Ameni, Gobena, Amodu, Olukemi, Anabwani, Gabriel, Andersen, Kristian, Arogundade, Fatiu, Arulogun, Oyedunni, Asogun, Danny, Bakare, Rasheed, Balde, Naby, Baniecki, Mary Lynn, Beiswanger, Christine, Benkahla, Alia, Bethke, Lara, Boehnke, Micheal, Boima, Vincent, Brandful, James, Brooks, Andrew I, Brosius, Frank C, Brown, Chester, Bucheton, Bruno, Burke, David T, Burnett, Barrington G, Carrington-Lawrence, Stacy, Carstens, Nadia, Chisi, John, Christoffels, Alan, Cooper, Richard, Cordell, Heather, Crowther, Nigel, Croxton, Talishiea, de Vries, Jantina, Derr, Leslie, Donkor, Peter, Doumbia, Seydou, Duncanson, Audrey, Ekem, Ivy, El Sayed, Ahmed, Engel, Mark E, Enyaru, John CK, Everett, Dean, Fadlelmola, Faisal M, Fakunle, Eyitayo, Fischbeck, Kenneth H, Fischer, Anne, Folarin, Onikepe, Gamieldien, Junaid, Garry, Robert F, Gaseitsiwe, Simani, Gbadegesin, Rasheed, Ghansah, Anita, Giovanni, Maria, Goesbeck, Parham, Gomez-Olive, F Xavier, Grant, Donald S, Grewal, Ravnit, Guyer, Mark, Hanchard, Neil A, Happi, Christian T, Hazelhurst, Scott, Hennig, Branwen J, Hertz-, Christiane, Fowler, Hide, Winston, Hilderbrandt, Friedhelm, Hugo-Hamman, Christopher, Ibrahim, Muntaser E, James, Regina, Jaufeerally-Fakim, Yasmina, Jenkins, Carolyn, Jentsch, Ute, Jiang, Pan-Pan, Joloba, Moses, Jongeneel, Victor, Joubert, Fourie, Kader, Mukthar, Kahn, Kathleen, Kaleebu, Pontiano, Kapiga, Saidi H, Kassim, Samar Kamal, Kasvosve, Ishmael, Kayondo, Jonathan, and Keavney, Bernard

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Genetics, Clinical Sciences, Medical Microbiology, Human Genome, Cancer, Infectious Diseases, HIV/AIDS, Clinical Research, Biotechnology, Rare Diseases, 2.6 Resources and infrastructure (aetiology), Aetiology, Infection, Good Health and Well Being, Africa, Disease, England, Genetics, Medical, Genome-Wide Association Study, Genomics, Health, Humans, National Institutes of Health (U.S.), United States, H3Africa Consortium, General Science & Technology
Abstract

H3Africa is developing capacity for health-related genomics research in Africa

Published
2014

21. FSGS Recurrence Collaboration: Report of a Symposium.

Author

Gipson, Debbie S., Wang, Chia-shi, Salmon, Eloise, Gbadegesin, Rasheed, Naik, Abhijit, Sanna-Cherchi, Simone, Fornoni, Alessia, Kretzler, Matthias, Merscher, Sandra, Hoover, Paul, Kidwell, Kelley, Saleem, Moin, Riella, Leonardo, Holzman, Lawrence, Jackson, Annette, Olabisi, Opeyemi, Cravedi, Paolo, Freedman, Benjamin Solomon, Himmelfarb, Jonathan, and Vivarelli, Marina

Subjects
FOCAL segmental glomerulosclerosis, DIABETIC nephropathies, INDUCTIVELY coupled plasma mass spectrometry
Abstract

This document is a report of a symposium on FSGS recurrence, a kidney disease characterized by podocyte injury and depletion. The report discusses the incidence of FSGS across different age groups and its contribution to nephrotic syndrome cases. It highlights the varying treatment protocols and the ongoing genetic studies to understand the disease. The text also explores different approaches and technologies used to study FSGS, including flow cytometric analysis, single-cell technologies, proteomic analysis, and the development of organoids and glomerular spheroids as models. The document emphasizes the need for further research and the challenges in conducting clinical trials for patients with recurrent FSGS. It also mentions the RESOLVE study as an example of collaborative efforts in gathering data on the disease. The potential of functional tools like human organoids in pre-clinical research is also discussed. [Extracted from the article]

Published
2024
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22. Rationale and design of the Nephrotic Syndrome Study Network (NEPTUNE) Match in glomerular diseases: designing the right trial for the right patient, today

Author

Massengill, Susan, Lo, Layla, Dell, Katherine, O’Toole, John, Sedor, John, Martin, Blair, Macumber, Ian, Sharma, Silpa, Srivastava, Tarak, Markus, Kelsey, Sethna, Christine, Vento, Suzanne, Canetta, Pietro, Olabisi, Opeyemi, Gbadegesin, Rasheed, Smith, Maurice, Greenbaum, Laurence, Wang, Chia-shi, Yun, Emily, Adler, Sharon, LaPage, Janine, Amarah, Amatur, Itteera, Mathew, Atkinson, Meredith, Williams, Miahje, Lieske, John, Hogan, Marie, Fervenza, Fernando, Selewski, David, Alston, Cheryl, Reidy, Kim, Ross, Michael, Kaskel, Frederick, Flynn, Patricia, Malaga-Dieguez, Laura, Zhdanova, Olga, Pehrson, Laura Jane, Miranda, Melanie, Almaani, Salem, Roberts, Laci, Lafayette, Richard, Dave, Shiktij, Lee, Iris, Shah, Shweta, Batla, Sadaf, Reich, Heather, Hladunewich, Michelle, Ling, Paul, Romano, Martin, Brakeman, Paul, Dylewski, James, Rogers, Nathan, McCarthy, Ellen, Creed, Catherine, Fornoni, Alessia, Bandes, Miguel, Kretzler, Matthias, Mariani, Laura, Modi, Zubin, Williams, A., Ni, Roxy, Nachman, Patrick, Rheault, Michelle, Kowalski, Amy, Rauwolf, Nicolas, Derebail, Vimal, Gibson, Keisha, Froment, Anne, Kelley, Sara, Holzman, Lawrence, Meyers, Kevin, Kallem, Krishna, Edwards, Aliya, Sharma, Samin, Roehm, Elizabeth, Sambandam, Kamalanathan, Brown, Elizabeth, Hellewege, Jamie, Jefferson, Ashley, Hingorani, Sangeeta, Tuttle, Katherine, Manahan, Linda, Pao, Emily, Kuykendall, Kelli, Lin, Jen Jar, Dharnidharka, Vikas, Gillespie, Brenda, Salmon, Eloise, Trachtman, Howard, Mainieri, Tina, Alter, Gabrielle, Arbit, Michael, Desmond, Hailey, Eddy, Sean, Fermin, Damian, Ju, Wenjun, Larkina, Maria, Lienczewski, Chrysta, Scherr, Rebecca, Troost, Jonathan, Williams, Amanda, Zhai, Yan, Kincaid, Colleen, Li, Shengqian, Li, Shannon, Gadegbeku, Crystal, Barisoni, Laura, Sampson, Matthew G., Smith, Abigail, Zee, Jarcy, Avila-Casado, Carmen, Bagnasco, Serena, Bu, Lihong, Caltharp, Shelley, Cassol, Clarissa, Demeke, Dawit, Hassler, Jared, Herlitz, Leal, Hewitt, Stephen, Hodgin, Jeff, Holanda, Danni, Kambham, Neeraja, Lemley, Kevin, Messias, Nidia, Mikhailov, Alexei, Moreno, Vanessa, Najafian, Behzad, Palmer, Matthew, Rosenberg, Avi, Royal, Virginie, Sekulik, Miroslav, Stokes, Barry, Thomas, David, Wu, Ming, Yamashita, Michifumi, Yin, Hong, Zuo . Cochairs, Yiqin, Nast, Cynthia, Williams, Amanda L., Mariani, Laura H., Ascani, Heather K., Uhlmann, Wendy R., Spino, Cathie, Holzman, Lawrence B., Sedor, John R., Subramanian, Lalita, Lienczewski, Chrysta C., Manieri, Tina, Roberts, Scott J., and Gipson, Debbie S.

Published
2024
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23. A randomized controlled trial of preemptive rituximab to prevent recurrent focal segmental glomerulosclerosis post-kidney transplant (PRI-VENT FSGS): protocol and study design

Author

Rheault, Michelle N., primary, Amaral, Sandra, additional, Bock, Margret, additional, Chambers, Eileen Tsai, additional, Chavers, Blanche, additional, Ters, Mireile El, additional, Garro, Rouba, additional, Gbadegesin, Rasheed, additional, Govil, Amit, additional, Harshman, Lyndsay, additional, Amer, Hatem, additional, Hooper, David K., additional, Israni, Ajay K., additional, Riad, Samy, additional, Sageshima, Junichiro, additional, Shapiro, Ron, additional, Seifert, Michael, additional, Smith, Jodi, additional, Sung, Randall, additional, Thomas, Christie P., additional, Wang, Qi, additional, and Verghese, Priya S., additional

Published
2023
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24. Innovations in MD-only physician-scientist training: experiences from the Burroughs Wellcome Fund physician-scientist institutional award initiative

Author

McElvaine, Allison T., Hawkins-Salsbury, Jacqueline A., Arora, Vineet M., Gladwin, Mark T., Goldenring, James R., Huston, David P., Krakow, Deborah, Rhee, Kyu, Solway, Julian, Steinman, Richard A., Towler, Dwight A., Utz, Paul J., Yokoyama, Wayne M., Simpson, Rolly L., Muglia, Louis J., Permar, Sallie R., and Gbadegesin, Rasheed A.

Subjects
Medical research -- Management -- Training, Medicine, Experimental -- Management -- Training, Continuing medical education -- Curricula, Physicians -- Training, Medical colleges -- Finance, Medical scientists -- Training, Company business management, Company financing, Health care industry
Abstract

Introduction In the first half of the 20th century, while the value of translating scientific discovery to clinical care was clearly established, the pace of innovation was resulting in increased [...]

Published
2021
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26. Cardiovascular Risk Factor Burden and Association With CKD in Ghana and Nigeria

Author

Olanrewaju, Timothy O., primary, Osafo, Charlotte, additional, Raji, Yemi R., additional, Mamven, Manmak, additional, Ajayi, Samuel, additional, Ilori, Titilayo O., additional, Arogundade, Fatiu A., additional, Ulasi, Ifeoma I., additional, Gbadegesin, Rasheed, additional, Parekh, Rulan S., additional, Tayo, Bamidele, additional, Adeyemo, Adebowale A., additional, Adedoyin, Olanrewaju T., additional, Chijioke, Adindu A., additional, Bewaji, Clement, additional, Grobbee, Diederick E., additional, Blankestijn, Peter J., additional, Klipstein-Grobusch, Kerstin, additional, Salako, Babatunde L., additional, Adu, Dwomoa, additional, and Ojo, Akinlolu O., additional

Published
2022
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28. Comparing Kidney Health Outcomes in Children, Adolescents, and Adults With Focal Segmental Glomerulosclerosis

Author

Gipson, Debbie S., primary, Troost, Jonathan P., additional, Spino, Cathie, additional, Attalla, Samara, additional, Tarnoff, Joshua, additional, Massengill, Susan, additional, Lafayette, Richard, additional, Vega-Warner, Virginia, additional, Adler, Sharon, additional, Gipson, Patrick, additional, Elliott, Matthew, additional, Kaskel, Frederick, additional, Fermin, Damian, additional, Moxey-Mims, Marva, additional, Fine, Richard N., additional, Brown, Elizabeth J., additional, Reidy, Kimberly, additional, Tuttle, Katherine, additional, Gibson, Keisha, additional, Lemley, Kevin V., additional, Greenbaum, Larry A., additional, Atkinson, Meredith A., additional, Hingorani, Sangeeta, additional, Srivastava, Tarak, additional, Sethna, Christine B., additional, Meyers, Kevin, additional, Tran, Cheryl, additional, Dell, Katherine M., additional, Wang, Chia-shi, additional, Yee, Jennifer Lai, additional, Sampson, Matthew G., additional, Gbadegesin, Rasheed, additional, Lin, J. J., additional, Brady, Tammy, additional, Rheault, Michelle, additional, and Trachtman, Howard, additional

Published
2022
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29. Collapsing Focal Segmental Glomerulosclerosis in Siblings With Compound Heterozygous Variants in NUP93 Expand the Spectrum of Kidney Phenotypes Associated With Nucleoporin Gene Mutations

Author

Cason, Rachel K., primary, Williams, Anna, additional, Chryst-Stangl, Megan, additional, Wu, Guanghong, additional, Huggins, Kinsie, additional, Brathwaite, Kaye E., additional, Lane, Brandon M., additional, Greenbaum, Larry A., additional, D’Agati, Vivette D., additional, and Gbadegesin, Rasheed A., additional

Published
2022
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30. Cure Glomerulonephropathy Pathology Classification and Core Scoring Criteria, Reproducibility, and Clinicopathologic Correlations

Author

Palmer, Matthew B, Royal, Virginie, Jennette, J. Charles, Smith, Abigail R., Liu, Qian, Ambruzs, Josephine M., Andeen, Nicole K., D’Agati, Vivette D., Fogo, Agnes B., Gaut, Joseph, Gbadegesin, Rasheed A., Greenbaum, Larry A., Hou, Jean, Helmuth, Margaret E, Lafayette, Richard A., Liapis, Helen, Robinson, Bruce, Stokes, Michael B., Twombley, Katherine, Yin, Hong, and Nast, Cynthia C.

Abstract

Introduction:Cure Glomerulonephropathy (CureGN) is an observational cohort study of patients with minimal change disease (MCD), focal segmental glomerulosclerosis (FSGS), membranous nephropathy (MN), or IgA nephropathy. We developed a conventional, consensus-based scoring system to document pathologic features for application across multiple pathologists and herein describe the protocol, reproducibility, and correlation with clinical parameters at biopsy. Methods:Definitions were established for glomerular, tubular, interstitial, and vascular lesions evaluated semiquantitatively using digitized light microscopy slides and electron micrographs, and reported immunofluorescence. Cases with curated pathology materials as of April 2019 were scored by a randomly assigned pathologist, with at least 10% of cases scored by a second pathologist. Scoring reproducibility was assessed using Gwet’s agreement coefficient (AC)1 statistic and correlations with clinical variables were performed. Results:Of 800 scored biopsies (134 MCD, 194 FSGS, 206 MN, 266 IgA), 94 were scored twice (11.8%). Of 60 pathology features, 46 (76.7%) demonstrated excellent (AC1>0.8), and 12 (20.0%) had good (AC1 0.6–0.8) reproducibility. Mesangial hypercellularity scored as absent, focal, or diffuse had moderate reproducibility (AC1 = 0.58), but good reproducibility (AC1 = 0.71) when scored as absent or focal versus diffuse. The percent glomeruli scored as no lesions had fair reproducibility (AC1 = 0.34). Strongest correlations between pathologic features and clinical characteristics at biopsy included interstitial inflammation, interstitial fibrosis, and tubular atrophy with estimated glomerular filtration rate, foot process effacement with urine protein/creatinine ratio, and active crescents with hematuria. Conclusions:Most scored pathology features showed excellent reproducibility, demonstrating consistency for these features across multiple pathologists. Correlations between certain pathologic features and expected clinical characteristics show the value of this approach for future studies on clinicopathologic correlations and biomarker discovery.

Published
2023
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32. Steroid-sensitive nephrotic syndrome candidate gene CLVS1 regulates podocyte oxidative stress and endocytosis

Author

Lane, Brandon M., primary, Chryst-Stangl, Megan, additional, Wu, Guanghong, additional, Shalaby, Mohamed, additional, El Desoky, Sherif, additional, Middleton, Claire C., additional, Huggins, Kinsie, additional, Sood, Amika, additional, Ochoa, Alejandro, additional, Malone, Andrew F., additional, Vancini, Ricardo, additional, Miller, Sara E., additional, Hall, Gentzon, additional, Kim, So Young, additional, Howell, David N., additional, Kari, Jameela A., additional, and Gbadegesin, Rasheed, additional

Published
2022
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33. Diagnosis, Education, and Care of Patients with APOL1-Associated Nephropathy: A Delphi Consensus and Systematic Review

Author

Freedman, Barry I., primary, Burke, Wylie, additional, Divers, Jasmin, additional, Eberhard, Lucy, additional, Gadegbeku, Crystal A., additional, Gbadegesin, Rasheed, additional, Hall, Michael E., additional, Jones-Smith, Tiffany, additional, Knight, Richard, additional, Kopp, Jeffrey B., additional, Kovesdy, Csaba P., additional, Norris, Keith C., additional, Olabisi, Opeyemi A., additional, Roberts, Glenda V., additional, Sedor, John R., additional, and Blacksher, Erika, additional

Published
2021
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34. A Rare Autosomal Dominant Variant in Regulator of Calcineurin Type 1 (RCAN1) Gene Confers Enhanced Calcineurin Activity and May Cause FSGS

Author

Lane, Brandon M., primary, Murray, Susan, additional, Benson, Katherine, additional, Bierzynska, Agnieszka, additional, Chryst-Stangl, Megan, additional, Wang, Liming, additional, Wu, Guanghong, additional, Cavalleri, Gianpiero, additional, Doyle, Brendan, additional, Fennelly, Neil, additional, Dorman, Anthony, additional, Conlon, Shane, additional, Vega-Warner, Virginia, additional, Fermin, Damian, additional, Vijayan, Poornima, additional, Qureshi, Mohammad Azfar, additional, Shril, Shirlee, additional, Barua, Moumita, additional, Hildebrandt, Friedhelm, additional, Pollak, Martin, additional, Howell, David, additional, Sampson, Matthew G., additional, Saleem, Moin, additional, Conlon, Peter J., additional, Spurney, Robert, additional, and Gbadegesin, Rasheed, additional

Published
2021
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35. Racial-Ethnic Differences in Health-Related Quality of Life among Adults and Children with Glomerular Disease

Author

Krissberg, Jill R., primary, Helmuth, Margaret E., additional, Almaani, Salem, additional, Cai, Yi, additional, Cattran, Daniel, additional, Chatterjee, Debanjana, additional, Gbadegesin, Rasheed A., additional, Gibson, Keisha L., additional, Glenn, Dorey A., additional, Greenbaum, Laurence A., additional, Iragorri, Sandra, additional, Jain, Koyal, additional, Khalid, Myda, additional, Kidd, Jason M., additional, Kopp, Jeffrey B., additional, Lafayette, Richard, additional, Nestor, Jordan G., additional, Parekh, Rulan S., additional, Reidy, Kimberly J., additional, Selewski, David T., additional, Sperati, C. John, additional, Tuttle, Katherine R., additional, Twombley, Katherine, additional, Vasylyeva, Tetyana L., additional, Weaver, Donald Jack, additional, Wenderfer, Scott E., additional, and O’Shaughnessy, Michelle M., additional

Published
2021
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39. Arhgap24 inactivates Rac1 in mouse podocytes, and a mutant form is associated with familial focal segmental glomeruosclerosis

Author

Akilesh, Shreeram, Suleiman, Hani, Yu, Haiyang, Stander, M. Christine, Lavin, Peter, Gbadegesin, Rasheed, Antignac, Corinne, Pollak, Martin, Kopp, Jeffrey B., Winn, Michelle P., and Shaw, Andrey S.

Subjects
Gene mutations -- Health aspects -- Research, Epithelial cells -- Physiological aspects -- Research, Kidney diseases -- Genetic aspects -- Research -- Risk factors, Health care industry
Abstract

The specialized epithelial cell of the kidney, the podocyte, has a complex actinbased cytoskeleton. Dynamic regulation of this cytoskeleton is required for efficient barrier function of the kidney. Podocytes are a useful cell type to study the control of the actin cytoskeleton in vivo, because disruption of components of the cytoskeleton results in podocyte damage, cell loss, and a prototypic injury response called focal segmental glomerulosclerosis (FSGS). Searching for actin regulatory proteins that are expressed in podocytes, we identified a RhoA-activated Rac1 GTPase-activating protein (Rac1-GAP), Arhgap24, that was upregulated in podocytes as they differentiated, both in vitro and in vivo. Increased levels of active Rac1 and Cdc42 were measured in Arhgap24 knockdown experiments, which influenced podocyte cell shape and membrane dynamics. Consistent with a role for Arhgap24 in normal podocyte functioning in vivo, sequencing of the ARHGAP24 gene in patients with FSGS identified a mutation that impaired its Rac1-GAP activity and was associated with disease in a family with FSGS. Thus, Arhgap24 contributes to the careful balancing of RhoA and Rac1 signaling in podocytes, the disruption of which may lead to kidney disease., Introduction The kidneys filter plasma and reabsorb solutes and nutrients to maintain the appropriate extracellular environment. The proximal component of the nephron, the glomerulus, is the primary filtration barrier that [...]

Published
2011
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40. COQ6 mutations in human patients produce nephrotic syndrome with sensorineural deafness

Author

Heeringa, Saskia F., Chernin, Gil, Chaki, Moumita, Zhou, Weibin, Sloan, Alexis J., Ji, Ziming, Xie, Letian X., Salviati, Leonardo, Hurd, Toby W., Vega-Warner, Virginia, Killen, Paul D., Raphael, Yehoash, Ashraf, hazia, Ovunc, Bugsu, Schoeb, Dominik S., McLaughlin, Heather M., Airik, Rannar, Vlangos, Christopher N., Gbadegesin, Rasheed, Hinkes, Bernward, Saisawat, Pawaree, Trevisson, Eva, Doimo, Mara, Casarin, Alberto, Pertegato, Vanessa, Giorgi, Gianpietro, Prokisch, Holger, Rotig, Agnes, Nurnberg, Gudrun, Becker, Christian, Wang, Su, Ozaltin, Fatih, Topaloglu, Rezan, Bakkaloglu, Aysin, Bakkaloglu, Sevcan A., Muller, Dominik, Beissert, Antje, Mir, Sevgi, Berdeli, Afig, Ozen, Seza, Zenker, Martin, Matejas, Verena, Santos-Ocana, Carlos, Navas, Placido, Kusakabe, Takehiro, Kispert, Andreas, Akman, Sema, Soliman, Neveen A., Krick, Stefanie, Mundel, Peter, Reiser, Jochen, Nurnberg, Peter, Clarke, Catherine F., Wiggins, Roger C., Faul, Christian, and Hildebrandt, Friedhelm

Subjects
Gene mutations -- Health aspects -- Research, Nephrotic syndrome -- Genetic aspects -- Risk factors -- Research, Deafness -- Genetic aspects -- Risk factors -- Research, Health care industry
Abstract

Steroid-resistant nephrotic syndrome (SRNS) is a frequent cause of end-stage renal failure. Identification of single-gene causes of SRNS has generated some insights into its pathogenesis; however, additional genes and disease [...]

Published
2011
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41. Establishing core outcome domains in pediatric kidney disease: report of the Standardized Outcomes in Nephrology—Children and Adolescents (SONG-KIDS) consensus workshops

Author

Guha, Abhjit, Solarin, Adaobi, Sinha, Aditi, Platona, Adriana, Hamilton, Alexander, Woods-Barnard, Alice, Neu, Alicia, Tong, Allison, Dart, Allison, Eddy, Allison, Karathanas, Alyssa, Baumgart, Amanda, Fielding, Amelia, LePage, Amelia, Bernier-Jean, Amelie, Kelly, Amy, Teixeira, Ana, Viecelli, Andrea, Matus, Andrea, Narva, Andrew, Ju, Angela, Wang, Angela Yee-Moon, Sharma, Ankit, Fielding, Anna, Francis, Anna, Meza, Anthony, Fielding, Aria, Teixeira-Pinto, Armando, Bagga, Arvind, Jankauskienė, Augustina, Kelly, Ayano, Gillespie, Barbara, Sautenet, Benedicte, Vogt, Beth, Foster, Bethany, Warady, Bradley, Dixon, Bradley, Manns, Braden, Hemmelgarn, Brenda, Bscardark, Brittney, Romeo, Brooklyn, Hanson, Camilla, Meza, Carlos, Brockett, Carter, Guha, Chandana, Prestidge, Chanel, Logeman, Charlotte, Green, Charmaine, Sanchez-Kazi, Cheryl, Perkins, Christy, Schmitt, Claus Peter, Fielding, Craig, Settee, Craig, Sumpton, Daniel, Meza, Daniel, Karathanas, Darien, Harris, David, Wheeler, David, Hooper, David, Gipson, Debbie, Geary, Denis, Bockenhauer, Detlef, Haffner, Dieter, Mekahli, Djalila, Drozdz, Dorota, Romeo, Ed, Ku, Elaine, Urbina, Elaine, Levtchenko, Elena, Balovlenkov, Elena, Hodson, Elisabeth, Morales, Emily, O'Lone, Emma, Machuca, Emma, Carlton, Emmah, Au, Eric, Olver, Erin, Morales, Estefania, Mirza, Fatima, Mackie, Fiona, Tentori, Francesca, Schaefer, Franz, Higgins, Gail, Deschenes, Georges, Plunkett, Georgia, Yoder, Gerilyn, Wong, Germaine, Morales, Giselle, Germino, Greg, Desmond, Hailey, Perkins, Hayley, Mitchell-Smith, Harrison, Coolican, Helen, Xu, Hong, Yap, Hui-Kim, Anochie, Ifeoma, Ha, Il-Soo, Davis, Ira, Liu, Isaac, Samaniego, Israel, Groothoff, Jaap, Machuca, Jaime, Machuca, James, Kerklaan, Jasmijn, Brockett, Jeff, Norton, Jenna, Shen, Jenny, Goebel, Jens, Rao, Jia, Machuca, Jimmy, Mitchell-Smith, Jo, Watson, Jo, Gill, John, Craig, Jonathan, Flynn, Joseph T., Kausman, Joshua, Samuels, Joshua, Bacchetta, Justine, Yoder, Kaleb, Manera, Karine, Azukaitis, Karolis, Twombley, Katherine, McMichael, Kelly-Ann, Ishikura, Kenji, Romeo, Kennedy, Settee, Kevin, Van, Kim Linh, McMichael, Lachlan, Trinh, Lany, Greenbaum, Larry, Sanchez, Laura, Fielding, Leo, Rees, Lesley, Lippincott, Leslie, Mejia-Saldivar, Levi, Saldivar, Lidia, Guay-Woodford, Lisa, Samaniego, Lizett, Hamiwka, Lorraine, Bell, Lorraine, Dunn, Louese, Barry, Lucinda, Macauley, Luke, Holmes, Luke, Karathanas, Madelynn, Mitchell-Smith, Madison, Walker, Mandy, Benavides, Manuel, Tonelli, Marcello, Ferris, Maria, Vivarelli, Marina, Wolfenden, Mark, Howell, Martin, Christian, Martin, Schreiber, Martin, Moxey-Mims, Marva, Leonard, Mary, Karathanas, Matthew, Pearl, Meghan, Natatmadja, Melissa, Brockett, Melissa, Bonilla-Felix, Melvin, Atkinson, Meredith, Zappitelli, Michael, Baum, Michel, Rheault, Michelle, McCulloch, Mignon, Matsuda-Abedini, Mina, Michael, Mini, Khan, Mohammad, Salih, Mohammad, Carlton, Mycah Ann, Benador, Nadine, Plunkett, Ngairre, Webb, Nick, Scholes-Robertson, Nicki, Larkins, Nicolas, Evangelidis, Nicole, Yoder, Nigel, Meza, Norma, Olver, Paige, Carlton, Paiyton, Brophy, Patrick, Tugwell, Peter, Cochat, Pierre, Mehrotra, Rajnish, Wolfenden, Raphael, Gbadegesin, Rasheed, Benavides, Raymond, Johnson, Rebecca, Morales, Ricardo, Jr., McGee, Richard, Fish, Richard, Gardos, Robert, Pecoits-Filho, Roberto, Vargas, Rocio, Saldivar, Rodolfo, Coppo, Rosanna, Shroff, Rukshana, Raina, Rupesh, Youssouf, Sajeda, Crowe, Sally, Anumudu, Samaya, Chan, Samuel, Baldacchino, Sarah, Wenderfer, Scott, Wolfenden, Sebastian, Carlton, Selah, Sutton, Shanna, Murphy, Shannon, Teo, Sharon, Salih, Sheyma, Sahney, Shobha, Carlton, Silas, Carter, Simon, Pearson, Simone, Khan, Simra, Wilson, Skyla, Sharma, Sonia, Alexander, Stephen, Marks, Stephen, Cornish, Stephen, Goldstein, Stuart, Samuel, Susan, Furth, Susan, Mendley, Susan, Lippincott, Susan, Charles, Symone, Gutman, Talia, Mitchell-Smith, Terri, Harris, Tess, Vetter, Thorsten, Carlton, Tiffany, Carlton, Timothy, Querfeld, Uwe, Saglimbene, Valeria, Charles, Virginia, van Biesen, Wim, Winkelmayer, Wolfgang, Machuca, Yenissey, Cho, Yeoungjee, Salih, Yusuf, Anh, Yo Han, Perkins, Zachary, Salih, Zeynab, Hanson, Camilla S., Craig, Jonathan C., Eddy, Allison A., Gipson, Debbie S., Webb, Nicholas J.A., Alexander, Stephen I., Furth, Susan L., Viecelli, Andrea K., Au, Eric H., Shen, Jenny I., Manera, Karine E., Carter, Simon A., and Walker, Amanda

Published
2020
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43. Management of idiopathic childhood nephrotic syndrome in sub-Saharan Africa: Ibadan consensus statement

Author

Esezobor, Christopher, primary, Ademola, Adebowale D., additional, Adetunji, Adewale E., additional, Anigilaje, Emmanuel A., additional, Batte, Anthony, additional, Jiya-Bello, Fatima N., additional, Furia, Francis F., additional, Muoneke, Uzoamaka, additional, McCulloch, Mignon, additional, Nourse, Peter, additional, Obiagwu, Patience, additional, Odetunde, Odutola, additional, Okyere, Perditer, additional, Solarin, Adaobi, additional, Tannor, Elliot K., additional, Noone, Damien, additional, Gbadegesin, Rasheed, additional, Parekh, Rulan S., additional, Ashuntantang, Gloria, additional, Georgette, Guemkam, additional, Adu, Dwamoa, additional, Adabayeri, Victoria May, additional, Boima, Vincent, additional, Osafo, Charlotte, additional, Tannor, Elliot Koranteng, additional, Antwi, Sampson, additional, Plange-Rhule, Jacob, additional, Mamven, Manmak, additional, Ajayi, Samuel, additional, Anigilaje, Emmanuel, additional, Okoye, Ogochukwu, additional, Okperi, Ofejiro, additional, Ighosewe, Okiroro, additional, Ulasi, Ifeoma, additional, Okafor, Henrietta U., additional, Salako, Babatunde, additional, Ademola, Adebowale, additional, Amodu, Kemi, additional, Raji, Yemi, additional, Adanze, Asinobi O., additional, Arogundade, Fatiu, additional, Olowu, Wasiu, additional, Olanrewaju, Timothy Olusegun, additional, Adedoyin, Olanrewaju, additional, Abdu, Aliyu, additional, Amira, Oluwatoyin, additional, Esezobor, Christopher, additional, Odenigbo, Charles, additional, Jisieike-Onuigbo, Nonyelum, additional, Musa, Adesola, additional, Audu, Rosemary, additional, Jinadu, Olanrewaju, additional, Makusidi, Muhammad, additional, Jiya Bello, Fatima Nma, additional, Awobusuyi, Jacob Olugbenga, additional, Furia, Francis Frederick, additional, Ruggajo, Paschal, additional, Shoo, Jacqueline, additional, Kalyesubula, Robert, additional, Kansiime, Grace, additional, Vasilevska-Ristovska, Jovanka, additional, Banh, Tonny H.M., additional, Ojo, Akinlolu O., additional, Wilson, Jillian, additional, Smith, Donna, additional, and Ilori, Titilayo, additional

Published
2021
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44. Common risk variants in NPHS1 and TNFSF15 are associated with childhood steroid-sensitive nephrotic syndrome

Author

Jia, Xiaoyuan, primary, Yamamura, Tomohiko, additional, Gbadegesin, Rasheed, additional, McNulty, Michelle T., additional, Song, Kyuyong, additional, Nagano, China, additional, Hitomi, Yuki, additional, Lee, Dongwon, additional, Aiba, Yoshihiro, additional, Khor, Seik-Soon, additional, Ueno, Kazuko, additional, Kawai, Yosuke, additional, Nagasaki, Masao, additional, Noiri, Eisei, additional, Horinouchi, Tomoko, additional, Kaito, Hiroshi, additional, Hamada, Riku, additional, Okamoto, Takayuki, additional, Kamei, Koichi, additional, Kaku, Yoshitsugu, additional, Fujimaru, Rika, additional, Tanaka, Ryojiro, additional, Shima, Yuko, additional, Baek, Jiwon, additional, Kang, Hee Gyung, additional, Ha, Il-Soo, additional, Han, Kyoung Hee, additional, Yang, Eun Mi, additional, Abeyagunawardena, Asiri, additional, Lane, Brandon, additional, Chryst-Stangl, Megan, additional, Esezobor, Christopher, additional, Solarin, Adaobi, additional, Dossier, Claire, additional, Deschênes, Georges, additional, Vivarelli, Marina, additional, Debiec, Hanna, additional, Ishikura, Kenji, additional, Matsuo, Masafumi, additional, Nozu, Kandai, additional, Ronco, Pierre, additional, Cheong, Hae Il, additional, Sampson, Matthew G., additional, Tokunaga, Katsushi, additional, Iijima, Kazumoto, additional, Araki, Yoshinori, additional, Nagaoka, Yoshinobu, additional, Sato, Yasuyuki, additional, Hayashi, Asako, additional, Takahashi, Toshiyuki, additional, Aoyagi, Hayato, additional, Ueno, Michihiko, additional, Nakanishi, Masanori, additional, Toita, Nariaki, additional, Uetake, Kimiaki, additional, Kobayashi, Norio, additional, Fujita, Shoji, additional, Tsuruga, Kazushi, additional, Kumagai, Naonori, additional, Kudo, Hiroki, additional, Tanaka, Eriko, additional, Omori, Tae, additional, Okada, Mari, additional, Hatai, Yoshiho, additional, Udagawa, Tomohiro, additional, Motoyoshi, Yaeko, additional, Ogura, Masao, additional, Sato, Mai, additional, Kano, Yuji, additional, Hattori, Motoshi, additional, Miura, Kenichiro, additional, Harita, Yutaka, additional, Kanda, Shoichiro, additional, Sawanobori, Emi, additional, Kobayashi, Anna, additional, Kojika, Manabu, additional, Ohwada, Yoko, additional, Yan, Kunimasa, additional, Hataya, Hiroshi, additional, Terano, Chikako, additional, Harada, Ryoko, additional, Hamasaki, Yuko, additional, Hashimoto, Junya, additional, Ito, Shuichi, additional, Machida, Hiroyuki, additional, Inaba, Aya, additional, Matsuyama, Takeshi, additional, Goto, Miwa, additional, Shimizu, Masaki, additional, Ohta, Kazuhide, additional, Ikezumi, Yohei, additional, Yamada, Takeshi, additional, Suzuki, Toshiaki, additional, Tamamura, Soichi, additional, Mori, Yukiko, additional, Hidaka, Yoshihiko, additional, Matsuoka, Daisuke, additional, Kinoshita, Tatsuya, additional, Noda, Shunsuke, additional, Kitahara, Masashi, additional, Fujita, Naoya, additional, Hibino, Satoshi, additional, Minamikawa, Shogo, additional, Nakanishi, Keita, additional, Fujimura, Junya, additional, Sakakibara, Nana, additional, Aoto, Yuya, additional, Ishiko, Shinya, additional, Kanda, Kyoko, additional, Inaguma, Yosuke, additional, Hashimura, Yuya, additional, Ishimori, Shingo, additional, Kamiyoshi, Naohiro, additional, Shibano, Takayuki, additional, Takeshima, Yasuhiro, additional, Ueda, Hiroaki, additional, Ashida, Akira, additional, Matsumura, Hideki, additional, Kubota, Takuo, additional, Kitaoka, Taichi, additional, Okuda, Yusuke, additional, Sawai, Toshihiro, additional, Sakai, Tomoyuki, additional, Hama, Taketsugu, additional, Fujieda, Mikiya, additional, Ishihara, Masayuki, additional, Itoh, Shigeru, additional, Iwaki, Takuma, additional, Shimizu, Maki, additional, Nagatani, Koji, additional, Kagami, Shoji, additional, Urushihara, Maki, additional, Nishimura, Manao, additional, Yoshino, Miwa, additional, Hatae, Ken, additional, Hinokiyama, Maiko, additional, Kuroki, Rie, additional, Ohtsuka, Yasufumi, additional, Oka, Masafumi, additional, Nishimura, Shinji, additional, Sato, Tadashi, additional, Tanaka, Seiji, additional, Zaitsu, Ayuko, additional, Nakazato, Hitoshi, additional, Tamura, Hiroshi, additional, Nakanishi, Koichi, additional, Cho, Min Hyun, additional, Ha, Tae-Sun, additional, Kim, Ji Hyun, additional, Park, Peong Gang, additional, Cho, Myung Hyun, additional, Quiroga, Alejandro, additional, Moudgil, Asha, additional, Chavers, Blanche, additional, Kwon, Charles, additional, Bowers, Corinna, additional, Gipson, Deb, additional, Chand, Deepa, additional, Weaver, Donald Jack, additional, Abraham, Elizabeth, additional, Janjua, Halima, additional, Lin, Jen-Jar, additional, Greenbaum, Larry, additional, Kallash, Mahmoud, additional, Rheault, Michelle, additional, De Jeus Gonzalez, Nilka, additional, Brophy, Patrick, additional, Nagaraj, Shashi, additional, Massengill, Susan, additional, Srivastava, Tarak, additional, Hunley, Tray, additional, Cai, Yi, additional, Omoloja, Abiodun, additional, Silva, Cynthia, additional, Adeyemo, Adebowale, additional, Thalgahagoda, Shenal, additional, Kari, Jameela A., additional, El Desoky, Sherif, additional, Abdelhadi, Mohammed, additional, Akil, Rachida, additional, Azib, Sonia, additional, Basmaci, Romain, additional, Benoist, Gregoire, additional, Bensaid, Philippe, additional, Blanc, Philippe, additional, Boyer, Olivia, additional, Bucher, Julie, additional, Chace, Anne, additional, Chalvon, Arnaud, additional, Cheminee, Marion, additional, Chendjou, Sandrine, additional, Daoud, Patrick, additional, Elias, Ossam, additional, Gagliadone, Chantal, additional, Gajdos, Vincent, additional, Galerne, Aurélien, additional, Aigrain, Evelyne Jacqz, additional, Sanchez, Lydie Joly, additional, Khaled, Mohamed, additional, Khelfaoui, Fatima, additional, Laoudi, Yacine, additional, Larakeb, Anis, additional, Limani, Tarek, additional, Mahdi, Fouad, additional, Mandelcwaijg, Alexis, additional, Muller, Stephanie, additional, Nacer, Kacem, additional, Nathanson, Sylvie, additional, Pellegrino, Béatrice, additional, Pharaon, Isabelle, additional, Roudault, Véronica, additional, Rouget, Sébastien, additional, Saf, Marc, additional, Simon, Tabassom, additional, Tahiri, Cedric, additional, Ulinski, Tim, additional, and Zenkhri, Férielle, additional

Published
2020
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45. Longitudinal Changes in Health-Related Quality of Life in Primary Glomerular Disease: Results From the CureGN Study

Author

Murphy, Shannon L., primary, Mahan, John D., additional, Troost, Jonathan P., additional, Srivastava, Tarak, additional, Kogon, Amy J., additional, Cai, Yi, additional, Davis, T. Keefe, additional, Fernandez, Hilda, additional, Fornoni, Alessia, additional, Gbadegesin, Rasheed A., additional, Herreshoff, Emily, additional, Canetta, Pietro A., additional, Nachman, Patrick H., additional, Reeve, Bryce B., additional, Selewski, David T., additional, Sethna, Christine B., additional, Wang, Chia-shi, additional, Bartosh, Sharon M., additional, Gipson, Debbie S., additional, Tuttle, Katherine R., additional, Gharavi, Ali, additional, Ahn, Wooin, additional, Appel, Gerald B., additional, Avasare, Rupali S., additional, Babayev, Revekka, additional, Batal, Ibrahim, additional, Bomback, Andrew S., additional, Brown, Eric, additional, Campenot, Eric S., additional, Canetta, Pietro, additional, Chan, Brenda, additional, D’Agati, Vivette D., additional, Foroncewicz, Bartosz, additional, Ghiggeri, Gian Marco, additional, Hines, William H., additional, Jain, Namrata G., additional, Kiryluk, Krzysztof, additional, Lin, Fangming, additional, Lugani, Francesca, additional, Marasa, Maddalena, additional, Markowitz, Glen, additional, Mohan, Sumit, additional, Mucha, Krzysztof, additional, Nickolas, Thomas L., additional, Radhakrishnan, Jai, additional, Rao, Maya K., additional, Regunathan-Shenk, Renu, additional, Sanna-Cherchi, Simone, additional, Santoriello, Dominick, additional, Stokes, Michael B., additional, Yu, Natalie, additional, Valeri, Anthony M., additional, Zviti, Ronald, additional, Greenbaum, Larry A., additional, Smoyer, William E., additional, Al-Uzri, Amira, additional, Ashoor, Isa, additional, Aviles, Diego, additional, Baracco, Rossana, additional, Barcia, John, additional, Bartosh, Sharon, additional, Belsha, Craig, additional, Braun, Michael C., additional, Chishti, Aftab, additional, Claes, Donna, additional, Cramer, Carl, additional, Davis, Keefe, additional, Erkan, Elif, additional, Feig, Daniel, additional, Freundlich, Michael, additional, Hanna, Melisha, additional, Hidalgo, Guillermo, additional, Jain, Amrish, additional, Khalid, Myda, additional, Kallash, Mahmoud, additional, Lane, Jerome C., additional, Mahan, John, additional, Mathews, Nisha, additional, Nester, Carla, additional, Pan, Cynthia, additional, Patel, Hiren, additional, Revell, Adelaide, additional, Sreedharan, Rajasree, additional, Steinke, Julia, additional, Wenderfer, Scott E., additional, Wong, Craig S., additional, Falk, Ronald, additional, Cook, William, additional, Derebail, Vimal, additional, Fogo, Agnes, additional, Gasim, Adil, additional, Gehr, Todd, additional, Harris, Raymond, additional, Kidd, Jason, additional, Laurin, Louis-Philippe, additional, Pendergraft, Will, additional, Pichette, Vincent, additional, Powell, Thomas Brian, additional, Renfrow, Matthew B., additional, Royal, Virginie, additional, Holzman, Lawrence B., additional, Adler, Sharon, additional, Alpers, Charles, additional, Matar, Raed Bou, additional, Brown, Elizabeth, additional, Choi, Michael, additional, Dell, Katherine M., additional, Dukkipati, Ram, additional, Fervenza, Fernando C., additional, Gadegbeku, Crystal, additional, Gipson, Patrick, additional, Hasely, Leah, additional, Hingorani, Sangeeta, additional, Hladunewich, Michelle A., additional, Hogan, Jonathan, additional, Jefferson, J. Ashley, additional, Jhaveri, Kenar, additional, Johnstone, Duncan B., additional, Kaskel, Frederick, additional, Kogan, Amy, additional, Kopp, Jeffrey, additional, Lemley, Kevin V., additional, Dieguez, Laura Malaga-, additional, Meyers, Kevin, additional, Neu, Alicia, additional, O'Shaughnessy, Michelle Marie, additional, O’Toole, John F., additional, Parekh, Rulan, additional, Reich, Heather, additional, Reidy, Kimberly, additional, Rondon, Helbert, additional, Sambandam, Kamalanathan K., additional, Sedor, John R., additional, Schelling, Jeffrey, additional, Sperati, John C., additional, Swiatecka-Urban, Agnes, additional, Trachtman, Howard, additional, Weisstuch, Joseph, additional, Zhdanova, Olga, additional, Gillespie, Brenda, additional, Kretzler, Matthias, additional, Robinson, Bruce M., additional, Mariani, Laura, additional, Wladkowski, Matthew, additional, and Guay-Woodford, Lisa M., additional

Published
2020
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46. Assessment of the Needs of Nephrology Divisions to Implement Return of Clinically Significant Research Genetic Results: A Survey of Nephrotic Syndrome Study Network (NEPTUNE) Investigators

Author

Fishbein, Jennifer E., Wilson Dass, Loryn, Lienczewski, Chrysta, Kretzler, Matthias, Gbadegesin, Rasheed A., Roberts, J. Scott, Sampson, Matthew G., and Uhlmann, Wendy

Abstract

Introduction:There is an increasing need to return genetic testing results to patients with kidney disease who were first genotyped on a research basis. Operationalizing this process in nephrology clinics is challenged by a limited number of genetic providers with whom to partner and a general lack of support services for all clinicians. Methods:We administered a survey in March 2022 to assess the current ability and ongoing needs of nephrology divisions to return clinically significant research genetic results to patients and to implement clinical genetic testing. This survey was distributed to institutions within the Nephrotic Syndrome Study Network (NEPTUNE) as part of the planning process for return of research genetic results to participants with pathogenic variants in Mendelian nephrotic syndrome genes. Results:Twenty-seven of 28 sites (96%) completed the survey. 59% (n= 16) of sites said they could handle return of research genetic results independently, with the rest expressing hesitation about the volume and complexity of patients and the limited resources and access to genetics services. 81% (n= 22) of these institutions did have a genetics clinic and 26% (n= 7) have a nephrology genetics clinic. However, 70% (n= 10) of these clinics have a waiting time over 1 month. 89% of divisions (n= 24) were conducting genetic testing and 96% of those (n= 23) used a kidney multi-gene panel. In 46% of divisions (n= 11), nephrologists were handling logistics of obtaining genetic testing samples themselves. Conclusion:We identified specific areas of support needed for return of clinically significant genetic results from research studies. While the surveyed nephrologists were conducting genetic testing, there were limitations in the support services available. This survey will help guide other research studies that wish to return genetic results to participants and also highlight the need for increasing support to effectively operationalize genetic testing in nephrology clinics.

Published
2022
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47. TRPC6 Enhances Angiotensin II-induced Albuminuria

Author

Eckel, Jason, Lavin, Peter J., Finch, Elizabeth A., Mukerji, Nirvan, Burch, Jarrett, Gbadegesin, Rasheed, Wu, Guanghong, Bowling, Brandy, Byrd, Alison, Hall, Gentzon, Sparks, Matthew, Zhang, Zhu Shan, Homstad, Alison, Barisoni, Laura, Birbaumer, Lutz, Rosenberg, Paul, and Winn, Michelle P.

Published
2011
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49. Establishing core outcome domains in pediatric kidney disease: report of the Standardized Outcomes in Nephrology—Children and Adolescents (SONG-KIDS) consensus workshops

Author

Hanson, Camilla S., primary, Craig, Jonathan C., additional, Logeman, Charlotte, additional, Sinha, Aditi, additional, Dart, Allison, additional, Eddy, Allison A., additional, Guha, Chandana, additional, Gipson, Debbie S., additional, Bockenhauer, Detlef, additional, Yap, Hui-Kim, additional, Groothoff, Jaap, additional, Zappitelli, Michael, additional, Webb, Nicholas J.A., additional, Alexander, Stephen I., additional, Furth, Susan L., additional, Samuel, Susan, additional, Neu, Alicia, additional, Viecelli, Andrea K., additional, Ju, Angela, additional, Sharma, Ankit, additional, Au, Eric H., additional, Desmond, Hailey, additional, Shen, Jenny I., additional, Manera, Karine E., additional, Azukaitis, Karolis, additional, Dunn, Louese, additional, Carter, Simon A., additional, Gutman, Talia, additional, Cho, Yeoungjee, additional, Walker, Amanda, additional, Francis, Anna, additional, Sanchez-Kazi, Cheryl, additional, Kausman, Joshua, additional, Pearl, Meghan, additional, Benador, Nadine, additional, Sahney, Shobha, additional, Tong, Allison, additional, Guha, Abhjit, additional, Solarin, Adaobi, additional, Platona, Adriana, additional, Hamilton, Alexander, additional, Woods-Barnard, Alice, additional, Eddy, Allison, additional, Karathanas, Alyssa, additional, Baumgart, Amanda, additional, Fielding, Amelia, additional, LePage, Amelia, additional, Bernier-Jean, Amelie, additional, Kelly, Amy, additional, Teixeira, Ana, additional, Viecelli, Andrea, additional, Matus, Andrea, additional, Narva, Andrew, additional, Wang, Angela Yee-Moon, additional, Fielding, Anna, additional, Meza, Anthony, additional, Fielding, Aria, additional, Teixeira-Pinto, Armando, additional, Bagga, Arvind, additional, Jankauskienė, Augustina, additional, Kelly, Ayano, additional, Gillespie, Barbara, additional, Sautenet, Benedicte, additional, Vogt, Beth, additional, Foster, Bethany, additional, Warady, Bradley, additional, Dixon, Bradley, additional, Manns, Braden, additional, Hemmelgarn, Brenda, additional, Bscardark, Brittney, additional, Romeo, Brooklyn, additional, Hanson, Camilla, additional, Meza, Carlos, additional, Brockett, Carter, additional, Prestidge, Chanel, additional, Green, Charmaine, additional, Perkins, Christy, additional, Schmitt, Claus Peter, additional, Fielding, Craig, additional, Settee, Craig, additional, Sumpton, Daniel, additional, Meza, Daniel, additional, Karathanas, Darien, additional, Harris, David, additional, Wheeler, David, additional, Hooper, David, additional, Gipson, Debbie, additional, Geary, Denis, additional, Haffner, Dieter, additional, Mekahli, Djalila, additional, Drozdz, Dorota, additional, Romeo, Ed, additional, Ku, Elaine, additional, Urbina, Elaine, additional, Levtchenko, Elena, additional, Balovlenkov, Elena, additional, Hodson, Elisabeth, additional, Morales, Emily, additional, O'Lone, Emma, additional, Machuca, Emma, additional, Carlton, Emmah, additional, Au, Eric, additional, Olver, Erin, additional, Morales, Estefania, additional, Mirza, Fatima, additional, Mackie, Fiona, additional, Tentori, Francesca, additional, Schaefer, Franz, additional, Higgins, Gail, additional, Deschenes, Georges, additional, Plunkett, Georgia, additional, Yoder, Gerilyn, additional, Wong, Germaine, additional, Morales, Giselle, additional, Germino, Greg, additional, Perkins, Hayley, additional, Mitchell-Smith, Harrison, additional, Coolican, Helen, additional, Xu, Hong, additional, Anochie, Ifeoma, additional, Ha, Il-Soo, additional, Davis, Ira, additional, Liu, Isaac, additional, Samaniego, Israel, additional, Machuca, Jaime, additional, Machuca, James, additional, Kerklaan, Jasmijn, additional, Brockett, Jeff, additional, Norton, Jenna, additional, Shen, Jenny, additional, Goebel, Jens, additional, Rao, Jia, additional, Machuca, Jimmy, additional, Mitchell-Smith, Jo, additional, Watson, Jo, additional, Gill, John, additional, Craig, Jonathan, additional, Flynn, Joseph T., additional, Samuels, Joshua, additional, Bacchetta, Justine, additional, Yoder, Kaleb, additional, Manera, Karine, additional, Twombley, Katherine, additional, McMichael, Kelly-Ann, additional, Ishikura, Kenji, additional, Romeo, Kennedy, additional, Settee, Kevin, additional, Van, Kim Linh, additional, McMichael, Lachlan, additional, Trinh, Lany, additional, Greenbaum, Larry, additional, Sanchez, Laura, additional, Fielding, Leo, additional, Rees, Lesley, additional, Lippincott, Leslie, additional, Mejia-Saldivar, Levi, additional, Saldivar, Lidia, additional, Guay-Woodford, Lisa, additional, Samaniego, Lizett, additional, Hamiwka, Lorraine, additional, Bell, Lorraine, additional, Barry, Lucinda, additional, Macauley, Luke, additional, Holmes, Luke, additional, Karathanas, Madelynn, additional, Mitchell-Smith, Madison, additional, Walker, Mandy, additional, Benavides, Manuel, additional, Tonelli, Marcello, additional, Ferris, Maria, additional, Vivarelli, Marina, additional, Wolfenden, Mark, additional, Howell, Martin, additional, Christian, Martin, additional, Schreiber, Martin, additional, Moxey-Mims, Marva, additional, Leonard, Mary, additional, Karathanas, Matthew, additional, Natatmadja, Melissa, additional, Brockett, Melissa, additional, Bonilla-Felix, Melvin, additional, Atkinson, Meredith, additional, Baum, Michel, additional, Rheault, Michelle, additional, McCulloch, Mignon, additional, Matsuda-Abedini, Mina, additional, Michael, Mini, additional, Khan, Mohammad, additional, Salih, Mohammad, additional, Carlton, Mycah Ann, additional, Plunkett, Ngairre, additional, Webb, Nick, additional, Scholes-Robertson, Nicki, additional, Larkins, Nicolas, additional, Evangelidis, Nicole, additional, Yoder, Nigel, additional, Meza, Norma, additional, Olver, Paige, additional, Carlton, Paiyton, additional, Brophy, Patrick, additional, Tugwell, Peter, additional, Cochat, Pierre, additional, Mehrotra, Rajnish, additional, Wolfenden, Raphael, additional, Gbadegesin, Rasheed, additional, Benavides, Raymond, additional, Johnson, Rebecca, additional, Morales, Ricardo, additional, McGee, Richard, additional, Fish, Richard, additional, Gardos, Robert, additional, Pecoits-Filho, Roberto, additional, Vargas, Rocio, additional, Saldivar, Rodolfo, additional, Coppo, Rosanna, additional, Shroff, Rukshana, additional, Raina, Rupesh, additional, Youssouf, Sajeda, additional, Crowe, Sally, additional, Anumudu, Samaya, additional, Chan, Samuel, additional, Baldacchino, Sarah, additional, Wenderfer, Scott, additional, Wolfenden, Sebastian, additional, Carlton, Selah, additional, Sutton, Shanna, additional, Murphy, Shannon, additional, Teo, Sharon, additional, Salih, Sheyma, additional, Carlton, Silas, additional, Carter, Simon, additional, Pearson, Simone, additional, Khan, Simra, additional, Wilson, Skyla, additional, Sharma, Sonia, additional, Alexander, Stephen, additional, Marks, Stephen, additional, Cornish, Stephen, additional, Goldstein, Stuart, additional, Furth, Susan, additional, Mendley, Susan, additional, Lippincott, Susan, additional, Charles, Symone, additional, Mitchell-Smith, Terri, additional, Harris, Tess, additional, Vetter, Thorsten, additional, Carlton, Tiffany, additional, Carlton, Timothy, additional, Querfeld, Uwe, additional, Saglimbene, Valeria, additional, Charles, Virginia, additional, van Biesen, Wim, additional, Winkelmayer, Wolfgang, additional, Machuca, Yenissey, additional, Salih, Yusuf, additional, Anh, Yo Han, additional, Perkins, Zachary, additional, and Salih, Zeynab, additional

Published
2020
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50. Persistent Disease Activity in Patients With Long-Standing Glomerular Disease

Author

Delbarba, Elisa, primary, Marasa, Maddalena, additional, Canetta, Pietro A., additional, Piva, Stacy E., additional, Chatterjee, Debanjana, additional, Kil, Byum Hee, additional, Mu, Xueru, additional, Gibson, Keisha L., additional, Hladunewich, Michelle A., additional, Hogan, Jonathan J., additional, Julian, Bruce A., additional, Kidd, Jason M., additional, Laurin, Louis-Philippe, additional, Nachman, Patrick H., additional, Rheault, Michelle N., additional, Rizk, Dana V., additional, Sanghani, Neil S., additional, Trachtman, Howard, additional, Wenderfer, Scott E., additional, Gharavi, Ali G., additional, Bomback, Andrew S., additional, Ahn, Wooin, additional, Appel, Gerald B., additional, Babayev, Revekka, additional, Batal, Ibrahim, additional, Brown, Eric, additional, Campenot, Eric S., additional, Canetta, Pietro, additional, Chan, Brenda, additional, D’Agati, Vivette D., additional, Delbarba, Elisa, additional, Fernandez, Hilda, additional, Foroncewicz, Bartosz, additional, Ghiggeri, Gian Marco, additional, Hines, William H., additional, Jain, Namrata G., additional, Kiryluk, Krzysztof, additional, Lau, Wai L., additional, Lin, Fangming, additional, Lugani, Francesca, additional, Markowitz, Glen, additional, Mohan, Sumit, additional, Mucha, Krzysztof, additional, Nickolas, Thomas L., additional, Piva, Stacy, additional, Radhakrishnan, Jai, additional, Rao, Maya K., additional, Sanna-Cherchi, Simone, additional, Santoriello, Dominick, additional, Stokes, Michael B., additional, Yu, Natalie, additional, Valeri, Anthony M., additional, Zviti, Ronald, additional, Greenbaum, Larry A., additional, Smoyer, William E., additional, Al-Uzri, Amira, additional, Ashoor, Isa, additional, Aviles, Diego, additional, Baracco, Rossana, additional, Barcia, John, additional, Bartosh, Sharon, additional, Belsha, Craig, additional, Bowers, Corinna, additional, Braun, Michael C., additional, Chishti, Aftab, additional, Claes, Donna, additional, Cramer, Carl, additional, Davis, Keefe, additional, Erkan, Elif, additional, Feig, Daniel, additional, Freundlich, Michael, additional, Gbadegesin, Rasheed, additional, Hanna, Melisha, additional, Hidalgo, Guillermo, additional, Hunley, Tracy E., additional, Jain, Amrish, additional, Kallash, Mahmoud, additional, Khalid, Myda, additional, Klein, Jon B., additional, Lane, Jerome C., additional, Mahan, John, additional, Mathews, Nisha, additional, Nester, Carla, additional, Pan, Cynthia, additional, Patterson, Larry, additional, Patel, Hiren, additional, Revell, Adelaide, additional, Silva, Cynthia, additional, Sreedharan, Rajasree, additional, Srivastava, Tarak, additional, Steinke, Julia, additional, Twombley, Katherine, additional, Vasylyeva, Tetyana L., additional, Weaver, Donald J., additional, Wong, Craig S., additional, Almaani, Salem, additional, Ayoub, Isabelle, additional, Budisavljevic, Milos, additional, Derebail, Vimal, additional, Fatima, Huma, additional, Falk, Ronald, additional, Fogo, Agnes, additional, Gehr, Todd, additional, Gibson, Keisha, additional, Glenn, Dorey, additional, Harris, Raymond, additional, Hogan, Susan, additional, Jain, Koyal, additional, Jennette, J. Charles, additional, Julian, Bruce, additional, Kidd, Jason, additional, Massey, H. Davis, additional, Mottl, Amy, additional, Nachman, Patrick, additional, Nadasdy, Tibor, additional, Novak, Jan, additional, Parikh, Samir, additional, Pichette, Vincent, additional, Poulton, Caroline, additional, Powell, Thomas Brian, additional, Renfrow, Matthew, additional, Rizk, Dana, additional, Rovin, Brad, additional, Royal, Virginie, additional, Saha, Manish, additional, Sanghani, Neil, additional, Self, Sally, additional, Adler, Sharon, additional, Alpers, Charles, additional, Matar, Raed Bou, additional, Brown, Elizabeth, additional, Cattran, Daniel, additional, Choi, Michael, additional, Dell, Katherine M., additional, Dukkipati, Ram, additional, Fervenza, Fernando C., additional, Fornoni, Alessia, additional, Gadegbeku, Crystal, additional, Gipson, Patrick, additional, Hasely, Leah, additional, Hingorani, Sangeeta, additional, Hladunewich, Michelle, additional, Hogan, Jonathan, additional, Holzman, Lawrence B., additional, Jefferson, J. Ashley, additional, Jhaveri, Kenar, additional, Johnstone, Duncan B., additional, Kaskel, Frederick, additional, Kogan, Amy, additional, Kopp, Jeffrey, additional, Lafayette, Richard, additional, Lemley, Kevin V., additional, Malaga-Dieguez, Laura, additional, Meyers, Kevin, additional, Neu, Alicia, additional, O’Shaughnessy, Michelle Marie, additional, O’Toole, John F., additional, Parekh, Rulan, additional, Reich, Heather, additional, Reidy, Kimberly, additional, Rondon, Helbert, additional, Sambandam, Kamalanathan K., additional, Sedor, John R., additional, Selewski, David T., additional, Sethna, Christine B., additional, Schelling, Jeffrey, additional, Sperati, John C., additional, Swiatecka-Urban, Agnes, additional, Tuttle, Katherine R., additional, Weisstuch, Joseph, additional, Vento, Suzanne, additional, Zhdanova, Olga, additional, Gillespie, Brenda, additional, Gipson, Debbie S., additional, Hill-Callahan, Peg, additional, Helmuth, Margaret, additional, Herreshoff, Emily, additional, Kretzler, Matthias, additional, Lienczewski, Chrysta, additional, Mansfield, Sarah, additional, Mariani, Laura, additional, Nast, Cynthia C., additional, Robinson, Bruce M., additional, Troost, Jonathan, additional, Wladkowski, Matthew, additional, Zee, Jarcy, additional, Zinsser, Dawn, additional, and Guay-Woodford, Lisa M., additional

Published
2020
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