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3. Dependence of Spending Patterns of Households on their Income in the Context of Health-Related Behaviour: Numerical Study

Author

Shelomentsev, A. G. and Goncharova, K. S.

Subjects
INEQUALITIES IN HEALTH CARE, SOCIO-ECONOMIC DEVELOPMENT OF RUSSIA, INCOME INEQUALITY, РАСХОДЫ ГРУПП ДОМОХОЗЯЙСТВ, СОЦИАЛЬНО-ЭКОНОМИЧЕСКОЕ РАЗВИТИЕ РОССИИ, HOUSEHOLD INCOME, САМОСОХРАНИТЕЛЬНОЕ ПОВЕДЕНИЕ, REFORMING THE RUSSIAN HEALTH CARE SYSTEM, ДОСТУПНОСТЬ МЕДИЦИНСКИХ УСЛУГ, АНАЛИЗ ДАННЫХ ОБДХ, ДИФФЕРЕНЦИАЦИЯ ДОХОДОВ НАСЕЛЕНИЯ, PRIORITIES OF THE RUSSIAN NATIONAL DEVELOPMENT, ПРИОРИТЕТЫ НАЦИОНАЛЬНОГО РАЗВИТИЯ РОССИИ, HOUSEHOLD EXPENDITURES, HEALTH-RELATED BEHAVIOUR, ДОХОДЫ ДОМОХОЗЯЙСТВ, НЕРАВЕНСТВО В СФЕРЕ ЗДРАВООХРАНЕНИЯ, AVAILABILITY OF MEDICAL SERVICES, РЕФОРМИРОВАНИЕ РОССИЙСКОЙ СИСТЕМЫ ЗДРАВООХРАНЕНИЯ, ANALYSIS OF HOUSEHOLD BUDGET SURVEYS
Abstract

The academic community has been actively discussing and assessing the results of the reform of the Russian healthcare system, which began in the early 2000s. This study considers the results of the reform from the perspective of a concept of health-related behaviour. The paper determines the behaviour patterns of household members concerning personal expenditures on medical goods and services, depending on their monetary income and spending pattern. The main research method was an econometric (correlation and regression) analysis of time series. As a result, we discovered that household income dynamics significantly influence expenditures on medical goods and hygiene items (that vary according to the household income). Moreover, household expenditures on health care depend on its spending on food products. We conclude that, firstly, in 2005–2019, Russia has been showing a steady growth of paid medical services (in total medical care), which are available to less than half of the households. Secondly, health-related behaviour of different groups of households divided by income level significantly changes depending on the income dynamics and spending pattern. Thirdly, an increase in income decreases expenditures on medical services and goods, as well as in an increase in expenditures on health-improvement (preventive) services. We have revealed that spending on food products on average determines 55.9 % of a change in expenditures on medical services. Simultaneously, in the households’ budgets, a 1 % increase in food expenditures displaces 2 % of expenditures on health-improvement services. The obtained results extend the understanding of the features of health-related behaviour that is defined by households’ income, as well as by the spending pattern on food, medical goods and services. Public authorities can consider the revealed features of health-related behaviour of different groups of households divided by income when developing and improving the socio-economic policy in the field of health care. Оценка результатов реформирования системы здравоохранения России, начавшегося в 2000-х гг., стала предметом активной научной дискуссии. В нашем исследовании результаты оценки рассматриваются в контексте концепции самосохранительного поведения населения. Целью исследования являлось определение моделей поведения членов домохозяйств в отношении расходования личных средств на медицинские товары и услуги, в зависимости от уровня их денежных доходов и структуры расходов. Исследование проведено с использованием эконометрического (корреляционно-регрессионного) анализа временных рядов. В результате были выявлены существенное влияние динамики доходов домохозяйств на долю их расходов на медицинские товары и предметы гигиены (различающееся по характеру в зависимости от уровня доходов домохозяйств), а также зависимость расходов домохозяйств на здравоохранение от уровня их затрат на покупку продуктов питания. В работе были сделаны следующие выводы: во-первых, в 2005–2019 гг. в нашей стране наблюдается устойчивая тенденция роста доли платных медицинских услуг в общем объеме медицинских услуг, воспользоваться которыми могут менее половины всех домохозяйств России, во-вторых, самосохранительное поведение различных по уровню доходов групп домохозяйств существенно различается при изменении динамики их доходов и структуры расходов, в-третьих, по мере роста доходов населения сокращается доля расходов на медицинские услуги и товары, а доля расходов санаторно-оздоровительного (профилактического) характера увеличивается. Так, определено, что уровень расходов на продукты питания в среднем определяет 55,9 % изменения расходов населения на медицинские услуги. В то же время повышение на 1 % их бюджета расходов на продукты питания вытесняет из него 2 % расходов на санаторно-оздоровительные услуги. Полученные результаты расширяют представления об особенностях самосохранительного поведения населения, определяющегося, с одной стороны, уровнем доходов, с другой — структурой расходов на продукты питания, медицинские товары и услуги. Выявленные в работе особенности самосохранительного поведения различных по уровню доходов групп населения могут быть использованы представителями органов государственной власти при разработке и совершенствовании государственной социально-экономической политики в сфере здравоохранения. The article has been prepared with the support of the Russian Foundation for Basic Research, the grant № 18–010–01049 «Methodology and methods of system assessment of interrelation of environmental factors and public health in the context of the Russian regions’ sustainable development». Статья выполнена при финансовой поддержке гранта РФФИ № 18–010–01049 «Методология и методика системной оценки взаимосвязи средовых факторов и здоровья населения в задаче устойчивого развития регионов России».

Published
2020

4. Численное исследование зависимости структуры расходов домохозяйств от уровня их доходов в контексте концепции самосохранительного поведения

Author

Shelomentsev, A. G., Goncharova, K. S., Шеломенцев, А. Г., Гончарова, К. С., Shelomentsev, A. G., Goncharova, K. S., Шеломенцев, А. Г., and Гончарова, К. С.

Abstract

The academic community has been actively discussing and assessing the results of the reform of the Russian healthcare system, which began in the early 2000s. This study considers the results of the reform from the perspective of a concept of health-related behaviour. The paper determines the behaviour patterns of household members concerning personal expenditures on medical goods and services, depending on their monetary income and spending pattern. The main research method was an econometric (correlation and regression) analysis of time series. As a result, we discovered that household income dynamics significantly influence expenditures on medical goods and hygiene items (that vary according to the household income). Moreover, household expenditures on health care depend on its spending on food products. We conclude that, firstly, in 2005–2019, Russia has been showing a steady growth of paid medical services (in total medical care), which are available to less than half of the households. Secondly, health-related behaviour of different groups of households divided by income level significantly changes depending on the income dynamics and spending pattern. Thirdly, an increase in income decreases expenditures on medical services and goods, as well as in an increase in expenditures on health-improvement (preventive) services. We have revealed that spending on food products on average determines 55.9 % of a change in expenditures on medical services. Simultaneously, in the households’ budgets, a 1 % increase in food expenditures displaces 2 % of expenditures on health-improvement services. The obtained results extend the understanding of the features of health-related behaviour that is defined by households’ income, as well as by the spending pattern on food, medical goods and services. Public authorities can consider the revealed features of health-related behaviour of different groups of households divided by income when developing and improving the socio-economic, Оценка результатов реформирования системы здравоохранения России, начавшегося в 2000-х гг., стала предметом активной научной дискуссии. В нашем исследовании результаты оценки рассматриваются в контексте концепции самосохранительного поведения населения. Целью исследования являлось определение моделей поведения членов домохозяйств в отношении расходования личных средств на медицинские товары и услуги, в зависимости от уровня их денежных доходов и структуры расходов. Исследование проведено с использованием эконометрического (корреляционно-регрессионного) анализа временных рядов. В результате были выявлены существенное влияние динамики доходов домохозяйств на долю их расходов на медицинские товары и предметы гигиены (различающееся по характеру в зависимости от уровня доходов домохозяйств), а также зависимость расходов домохозяйств на здравоохранение от уровня их затрат на покупку продуктов питания. В работе были сделаны следующие выводы: во-первых, в 2005–2019 гг. в нашей стране наблюдается устойчивая тенденция роста доли платных медицинских услуг в общем объеме медицинских услуг, воспользоваться которыми могут менее половины всех домохозяйств России, во-вторых, самосохранительное поведение различных по уровню доходов групп домохозяйств существенно различается при изменении динамики их доходов и структуры расходов, в-третьих, по мере роста доходов населения сокращается доля расходов на медицинские услуги и товары, а доля расходов санаторно-оздоровительного (профилактического) характера увеличивается. Так, определено, что уровень расходов на продукты питания в среднем определяет 55,9 % изменения расходов населения на медицинские услуги. В то же время повышение на 1 % их бюджета расходов на продукты питания вытесняет из него 2 % расходов на санаторно-оздоровительные услуги. Полученные результаты расширяют представления об особенностях самосохранительного поведения населения, определяющегося, с одной стороны, уровнем доходов, с другой — структурой расходов на продукты пит

Published
2020

5. Socio-Economic Policy, Aimed to Reduce Population Economic Inequality (on the Example of Subjects of Central Federal District)

Author

Goncharova, K. S.

Subjects
ГОСУДАРСТВЕННАЯ РЕГИОНАЛЬНАЯ ПОЛИТИКА, INCOME INEQUALITY OF POPULATION, STATE REGIONAL POLICY, НЕРАВЕНСТВО ДОХОДОВ НАСЕЛЕНИЯ
Abstract

In this study, a content-analysis method identified a main directions and tools of state policy implemented at federal and regional levels in the field of socio-economic differentiation of a population. An analysis of legal acts and strategic documents made it possible to identify three main approaches to solving a problem of inequality: creating equal conditions for all economic agents, ensuring fair distribution of benefits and raising a standard of living of a population due to a quality of economic growth of subjects of the Federation. В настоящем исследовании методом контент-анализа были определены основные направления и инструменты реализуемой на федеральном и региональном уровнях государственной политики в области социально-экономической дифференциации населения. Проведенный анализ нормативно-правовых актов и стратегических документов позволил выявить три основных подхода к решению проблемы неравенства: создания равенства условий для всех экономических агентов; обеспечения справедливости распределения благ; повышения уровня жизни населения за счет качества экономического роста субъектов Федерации. Публикация выполнена при поддержке гранта РФФИ № 18-010-01049 «Методология и методика системной оценки взаимосвязи средовых факторов и здоровья населения в задаче устойчивого развития регионов России».

Published
2019

6. Социально-экономическая политика, направленная на снижение экономического неравенства населения (на примере субъектов цфо)

Author

Goncharova, K. S., Гончарова, К. С., Goncharova, K. S., and Гончарова, К. С.

Abstract

In this study, a content-analysis method identified a main directions and tools of state policy implemented at federal and regional levels in the field of socio-economic differentiation of a population. An analysis of legal acts and strategic documents made it possible to identify three main approaches to solving a problem of inequality: creating equal conditions for all economic agents, ensuring fair distribution of benefits and raising a standard of living of a population due to a quality of economic growth of subjects of the Federation., В настоящем исследовании методом контент-анализа были определены основные направления и инструменты реализуемой на федеральном и региональном уровнях государственной политики в области социально-экономической дифференциации населения. Проведенный анализ нормативно-правовых актов и стратегических документов позволил выявить три основных подхода к решению проблемы неравенства: создания равенства условий для всех экономических агентов; обеспечения справедливости распределения благ; повышения уровня жизни населения за счет качества экономического роста субъектов Федерации.

Published
2019

7. The pig as a model for premature infants - the importance of immunoglobulin supplementation for growth and development

Author

Socha-Banasiak, A., Stefan Grzegorz Pierzynowski, Woliński, J., Grujic, D., Boryczka, M., Grzesiak, P., Szczurek, P., Czkwianianc, E., Westrom, B., and Goncharova, K.

Subjects
Animals, Newborn, Pregnancy, Swine, Colostrum, Dietary Supplements, Models, Animal, Infant, Newborn, Animals, Humans, Immunoglobulins, Female, Animal Feed, Infant, Premature
Abstract

Preterm human neonates, contrary to preterm piglets, obtain immunoglobulins from their mothers via the placenta during intrauterine development. However, one should note that the majority of trans-placental transfer of immunoglobulins in humans takes place during the last trimester of pregnancy. It is also known that the feeding of limited amounts of colostrum or systemic infusion of small amounts of serum improves the survival of preterm and full-term piglets. Full-term piglets deprived of their mother’s immunoglobulins exhibit strong apathy and develop watery diarrhoea, often resulting in death. The aim of the current study was to determine if provision of immunoglobulins using different approaches would be beneficial for survival outcomes. To reach the immunological sufficient level we infused immunoglobulins intravenously in amount mimicking the blood level in piglets fed with sow colostrum. Intravenous infusion of immunoglobulins in both preterm and full-term newborn piglets fully ensured their survival, growth and blood immunoglobulin G and protein levels similar to those observed in piglets fed colostrum. Piglets completely deprived of immunoglobulins exhibited significantly lower blood levels of immunoglobulins and protein compared to colostrum-fed animals. Piglets infused with only serum exhibited significantly lower blood immunoglobulin G level compared to those infused with immunoglobulins. In conclusion, based on the data obtained, we suggest that passive immune support provided by colostrum intake or early systemic infusion of Ig’s in sufficient amounts is key to ensuring the general well-being of preterm and full-term new born piglets, used as an animal model for the human infant.

Published
2017

8. Evaluation of the influence of economic growth on differentiation of population income in the regions of Urals Federal District

Author

Goncharova, K. S.

Subjects
ЭКОНОМИЧЕСКИЙ РОСТ, INCOME DIFFERENTIATION, GROSS REGIONAL PRODUCT, ВАЛОВОЙ РЕГИОНАЛЬНЫЙ ПРОДУКТ, ДИФФЕРЕНЦИАЦИЯ ДОХОДОВ, ECONOMIC GROWTH, GINI INDEX, ИНДЕКС ДЖИНИ
Abstract

В работе представлен анализ оценки влияния экономического роста на неравномерность распределения доходов населения на примере 6 регионов Уральского Федерального Округа. Выявлена типологизация анализируемых зависимостей в разрезе периода: 2000-2014 годов. The article an analysis of the assessment of the impact of economic growth on the uneven distribution of income of the population by the example of the five regions of the Urals Federal District. The typology of the analyzed dependencies was determined in the context of the period: 2000-2014.

Published
2017

9. A032 – Health, lifestyle and aging with Multiple Sclerosis: A qualitative study

Author

Arnold, Catherine M., Faulkner, Robert A., Ploughman, Michelle, Austin, Mark, Kearney, Anne, Murdoch, Michelle, Stefanelli, Mark, Godwin, Marshall, Muir, Susan W, Speechley, Mark, Borrie, Michael, Montero-Odasso, Manuel, MacKay-Lyons, M, Creaser, G, Macdonald, A, McKenna, J, Murphy, S, O'Neill, VR, Nilsson, T, Begley, L, Ikert, Kathy M., Long, Kristin M., Bittner, Darren R., Birmingham, Trevor B., Bryant, Dianne M., Richardson, Julie, Letts, Lori, Chan, David, Stratford, Paul, Hand, Carri, Price, David, Hilts, Linda, Coman, Liliana, Edwards, Mary, Baptiste, Sue, Law, Mary, Alexander, Elliot, Rosenthal, Stephanie, Guilcher, Sara, Evans, Cathy, Gattey, M, Hydomako, R, McLean, B, O'Leary, J, Shkopich, K, Klassen, L, Laprade, Judi, Roy, Marla, Laing, M, Di Nicolantonio, L, Goncharova, K, Pui, M, Vas, H, House, R, Switzer-McIntyre, S, Cheifetz, O, Serediuk, F, Park Dorsay, J, Hladysh, G, Woodhouse, L, Dalzell, MA, Shallwani, S, Preuss, RA, Patterson, Debbie, Ptak, Janice, Howe, JA, Brunton, K, Salisbury, K, Sharma, SK, Childerhose, DE, Sharma, S, WalkerJohnston, JA, Barnes, JL, Fisher, Megan E., Aristone, Martha N., Young, Katrina K., Waechter, Laurie E., Landry, Michel D., Taylor, Leslie A., Cooper, Nicole S., Wong, S, Hébert, Luc J., Rowe, Peter, Debouter, Kelly, Lai, Denise, Winn, CS, Chisholm, BA, Hummelbrunner, JA, Wasson, Pamela, Passalent, L, Soever, L, Kennedy, C, Warmington, K, Shupak, R, Thomas, R, Linekar, S, Lundon, K, Morgan, Dale, Kelly, Larry, Hastie, Robyn, Deber, Raisa B., Verrier, Molly C., O'Callaghan, L, Alexander, E, Titus, D, MacDougall, P, Hoens, AM, Garland, SJ, Tunnacliffe, R, Lineker, S, Varatharasan, N, Schneider, R, MacKay, C, Murphy, SM, Wu, Kenneth, Fox, Patricia, Tullis, Elizabeth, Stephenson, Anne L., Davis, AM, Mahomed, N, Badley, EM, Scott, Lisa, Carpenter, Christine, Brander, Rosemary R., Paterson, Margo L., Chan, Yolande E., Reinikka, KJE, French, E, Huijbregts, M, Cleaver, SR, Paulenko, T, Hebert, D, Creaser, GA, MacKenzie, D, Barkhouse-McKeen, C, Shrier, Ian, Freeman, K, Davidson, L, Pelland, L, Wilson, Nicole, Hopkins-Rosseel, Diana, Fraser, M, Wainwright, G, MacCormack, B, Basque Godin, C, Mori, B, Evans, C, Gibson, BE, Thornton, M, Dutton, T, King, J, Lawrence, PJ, Duggan, M, Hoens, A, Geddes, E Lynne, Gill, Caroline, Fong-Lee, Dianna, Lindsay, Jane, McPhail, Stacey, McIntosh, Karen, Marken, Suri L., Dutton, Tanya, Hopkins-Rosseel, DH, Kasdan, P, Fong-Lee, D., Marken, Siri, Moreside, JM, McGill, SM, Juma, S, Winter Di Cola, JL, Kennedy, DM, Dickson, P, Denis, S, Robarts, S, Gollish, J, Salbach, NM, Veinot, P, Jaglal, SB, Bayley, M, Rolfe, D, Dogra, M, Woodhouse, LJ, Spadoni, GF, Stratford, PW, Fox, P, Sessford, J, Beaton, D, Harniman, E, Inrig, T, Baxter, K, Portanova, A, Smuck, L, Connelly, DM, Shaw, J, Adkin, A, Jog, M, Hollway, D, Earl, M, Murphy, A, MacDonald, E, Overend, TJ, Brooks, D, Anderson, CM, Cicutto, L, Keim, M, McAuslan, D, Nonoyama, M, Levac, D., Pierrynowski, M., MacPherson, M, Glassman, L, Jadan, P, MacArthur, L, Landry, M, Frenette, J, Dumont, N, Moreland, JD, DePaul, VG, DeHueck, AL, Musselman, KE, Yang, JF, Tousignant, M, Moffet, H, Boissy, P, Corriveau, H, Cabana, F, Marquis, F, Towns, Megan, Barrett, Lauren, Darling, Catherine, Lee, Michelle, Aganon, Isabel, Hill, Kylie, Brooks, Dina, Robbins, Shawn, Alcock, Greg, Maly, Monica, Jones, Gareth, Birmingham, Trevor, Glazebrook, Cheryl M., Wright, F. Virginia, Martin, MBA, Norton, B, Ramsaran, KD, Street, ME, Syed, SN, Dang, MT, Barclay-Goddard, R, Stratford, P, Miller, P, Karam, J., Zettel, M., Green, K., Carter, D., Lam, F., Evans, C., Yeung, E., Lindquist, NJ, Magis, TF, Rispin, JE, Walton, PE, Kirby, RL, Manns, PJ, Haller, MK, Marler, K, Lore, S, Sottana, B, Crowley, A, Beaudin, V, Sloan, C, Landry, SC, Nigg, BM, Tecante, KE, Albers, Pamela, Devon, Heidi, Nairn, Lacey, Olenick, Betsy, Roach, Stephanie, Arnold, Cathy, Watts, Cathy, Wieler, M, Jones, CA, Allen, J, Haennel, R, Shaw, JA, Zecevic, A, Dal Bello-Haas, V, Harrision, L, Kanthan, R, Lawson, S, Zaluski, N, Petrie, A, Rohs, J, Parker, R, Roy, JS, MacDermid, JC, Roth, JH, Grewal, R, Officer, Alexis, DePaul, Vincent, Bosch, Jackie, Wilkins, Seanne, Wishart, Laurie, Inness, EL, Mansfield, A, Biasin, L, Prajapati, S, Lakhani, B, Mileris, R, McIlroy, WE, Henderson, RJ, Vanik, J, Alyoshkina, N, Diamond, C, Lee, J, Martinov, K, O'Brien, KK, Alexander, R, King, K, Murray, J, Tebeje, M, Bayoumi, AM, Bereket, T, Swinton, M, Norman, G, Solomon, P, Anstey, S, Bethune, M, Thomas, A, Wood-Salomon, E, Curwin, S, D'Amboise, SN, Héroux, ME, Pari, G, Norman, KE, Lee, Linda-Joy, Coppieters, Michel W., Hodges, Paul W., Perreault, Audrey, Tremblay, Louis E., Thibault-Gagnon, S, Gentilcore-Saulnier, E, McLean, L, Kay, JL, McNeely, ML, Campbell, KL, Peddle, CJ, Courneya, KS, Subramanian, SK, Levin, MF, Dechman, G, Tupper, SM, Levesque, L, Reese, H, Nailer, T, Walton, D, Schachter, CL, Stalker, CA, Teram, E, Lasiuk, G, Bartlett, Doreen, Chiarello, Lisa, Jacobs, Diane, Busch, Angela, Novak, Christine B., Anastakis, Dimitri J., Beaton, Dorcas E., Mackinnon, Susan E., Katz, Joel, Figueiredo, S, Finch, L, Jiali, M, Ahmed, S, Huang, A, Mayo, NE, Lochhead, Lois, MacMillan, Peter, DePaul, V, Burridge, H, Kwok, C, Rosario, J, Stogios, C, McKay, E, Moyer, E, Wishart, L, Holly, J, DYER, Joseph-Omer, MAUPAS, Éric, de ANDRADE MELO, Sibele, BOURBONNAIS, Daniel, FORGET, Robert, Shrier, I, Boudier-Reveret, M, Feldman, D, Mazer, B, Rege, SS, Soever, LJ, Fenety, Anne, Hoens, Alison, Harman, Katherine, Bassett, Raewyn, Byrne, Jeannette M., Prentice, Stephen D., Carlesso, Lisa, Cairney, John, Hoogenes, Jennifer, Gabison, S, Nussbaum, EL, Taillon-Hobson, A., McLean, L., Aaron, S., Bilodeau, M., Taillon-Hobson, Anne, McLean, Linda, Aaron, Shawn, Bilodeau, Martin, Zbarsky, Kathryn, Parsley, Dana, Clegg, Heather, Welch, Tyler, Fernandes, Catherine, Jaglal, Susan, Inness, Liz, Williams, Josh, McIlroy, William, Howe, Jo-Anne, Yardley, D, Benoit, M, Blake, T, Gillies, G, Ho, R, MacKinnon, M, Chesworth, BM, Busch, AJ, Dooley, A, Coons, S, Crockett, K, Mucha, J, Kean, CO, Birmingham, TB, King, LK, Giffin, JR, Lourenço, Christiane B., Subramanian, Sandeep, Sveistrup, Heidi, Levin, Mindy F., DESMEULES, FRANÇOIS, DIONNE, CLERMONT E., BELZILE, ÉTIENNE L., BOURBONNAIS, RENÉE, FRÉMONT, PIERRE, Richards, CL, Schneider, GM, Smith, AD, Bath, B, Bourassa, R, Lovo Grona, S, Schneider, KJ, Emery, Carolyn, Norman, Kathleen, Pearson, Neil, Woodhouse, Linda, Pelland, Lucie, Werstine, Rob, and Schneider, Kathryn

Subjects
active transfer strategies for informing clinical practice through information technologies, injury prevention, health human resources management strategies, Merging Research and Practice, implementation and management strategies, Abstracts, clinical experience, clinical skills and clinical reasoning modules in orthopaedic practice, Special Sessions, evolving physiotherapist roles, chronic disease prevention, neurological, basic science or clinically focused research on targeted physiotherapy interventions, Scientific sessions, fundamental scientific research, mobility, Newfoundland, Canadian Physiotherapy Association Congress 2010, population health services, advances in research related to neuromusculoskeletal practice, health system reform, patient and client preference, clinical research and the reciprocal transfer of knowledge between clinical practice and research, innovative service delivery models, post-operative management of acute care patients, promotion of research, practice and patient/client care in the neuromusculoskeletal area, Canada, assessment and treatment of disability that arises from both spinal and peripheral pathologies, Abstracts, CPA Congress 2010, role of physiotherapists in primary health care, exercise prescription, Physical Therapy, Sports Therapy and Rehabilitation, Health Promotion, clinical decision making, St. John's, evidence based practice model, informing the development of clinical research questions, determinants of health, innovative models of practice, physiotherapy leadership development, Physio10, Leadership in Action, public and patient education, musculoskeletal, benchmarking areas of practice, inter-professional collaboration and education strategies, Neuromusculoskeletal Practice, public, private and independent practice management of physiotherapy services, Merging Research with Practice, cardio-respiratory
Published
2010
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10. Оценка влияния экономического роста на дифференциацию доходов населения в регионах УРФО

Author

Гончарова, К. С., Goncharova, K. S., Гончарова, К. С., and Goncharova, K. S.

Abstract

В работе представлен анализ оценки влияния экономического роста на неравномерность распределения доходов населения на примере 6 регионов Уральского Федерального Округа. Выявлена типологизация анализируемых зависимостей в разрезе периода: 2000-2014 годов., The article an analysis of the assessment of the impact of economic growth on the uneven distribution of income of the population by the example of the five regions of the Urals Federal District. The typology of the analyzed dependencies was determined in the context of the period: 2000-2014.

Published
2017

14. Experiments suggesting extra-digestive effects of enteral pancreatic amylase and its peptides on glucose homeostasis in a pig model.

Author

Pierzynowski SG, Goncharova K, Gregory PC, Weström B, Podpryatov SE, Podpriatov SS, Woliński J, Repich H, Wierup N, and Lozinska L

Subjects
Animals, Bariatric Surgery methods, Digestion drug effects, Duodenum surgery, Female, Glucose Tolerance Test methods, Insulin blood, Jejunum surgery, Male, Pancreas enzymology, Swine, alpha-Amylases chemistry, Blood Glucose metabolism, Homeostasis drug effects, Peptides administration & dosage, alpha-Amylases administration & dosage
Abstract

The studies presented were designed to highlight the impact of pancreatic enzymes on glycemic control and insulin response. Blood glucose and plasma insulin levels were monitored after intravenous, oral or direct gut glucose tolerance tests (GTT) in 6 pigs with an intact gastrointestinal tract and in 12 pigs following duodenal-jejunal bypass (DJB) surgery. In the intact pigs, pancreatic enzymes (Creon®) given orally 1 h prior to the GTT, lowered the blood glucose levels during the oral and meal GTT and reduced the plasma insulin response during the intravenous and meal GTT. In DJB pigs, blood glucose and plasma insulin levels were higher following glucose loading into the by-passed biliopancreatic limb as compared to that following glucose loading orally or into the common intestinal limb. Infusion of amylase or amylase peptides together with glucose into the biliopancreatic limb lowered blood glucose levels in DJB pigs. These preliminary data suggest new, extra-digestive, actions of enteral pancreatic enzymes - probably amylase or its peptides - on glucose homeostasis, with an reduction in net glucose absorption into the blood and in insulin response. This ability of digestive enzymes (amylase) to reduce post-prandial hyperglycaemia in an insulin-independent manner could aid in preventing the development of obesity and diabetes.

Published
2017
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15. Importance of neonatal immunoglobulin transfer for hippocampal development and behaviour in the newborn pig.

Author

Goncharova K, Lozinska L, Arevalo Sureda E, Woliński J, Weström B, and Pierzynowski S

Subjects
Animals, Animals, Newborn immunology, Animals, Newborn psychology, Discrimination, Psychological physiology, Enzyme-Linked Immunosorbent Assay, Exploratory Behavior physiology, Female, Hippocampus immunology, Immunity, Maternally-Acquired immunology, Immunoglobulin G blood, Immunoglobulin G cerebrospinal fluid, Immunoglobulin G immunology, Immunoglobulins immunology, Male, Smell physiology, Swine immunology, Swine psychology, Animals, Newborn growth & development, Hippocampus growth & development, Immunity, Maternally-Acquired physiology, Immunoglobulins physiology, Swine growth & development
Abstract

Neurological disorders are among the main clinical problems affecting preterm children and often result in the development of communication and learning disabilities later in life. Several factors are of importance for brain development, however the role of immunoglobulins (passive immunity transfer) has not yet been investigated. Piglets are born agammaglobulinemic, as a result of the lack of transfer of maternal immunoglobulins in utero, thus, they serve as an ideal model to mimic the condition of immunoglobulin deficiency in preterm infants. Thirty six, unsuckled newborn piglets were fed an infant formula or colostrum and supplemented orally or intravenously with either species-specific or foreign immunoglobulin and then compared to both newborn and sow-reared piglets. Two days after the piglets were born behavioural tests (novel recognition and olfactory discrimination of conspecifics scent) were performed, after which the piglets were sacrificed and blood, cerebrospinal fluid and hippocampi samples were collected for analyses. Both parameters of neuronal plasticity (neuronal maturation and synapse-associated proteins) and behavioural test parameters appeared to be improved by the appearance of species-specific porcine immunoglulin in the circulation and cerebrospinal fluid of the piglets. In conclusion, we postulate possible positive clinical effects following intravenous infusion of human immunoglobulin in terms of neuronal plasticity and cognitive function in preterm infants born with low blood immunoglobulin levels.

Published
2017
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16. Oral uricase eliminates blood uric acid in the hyperuricemic pig model.

Author

Szczurek P, Mosiichuk N, Woliński J, Yatsenko T, Grujic D, Lozinska L, Pieszka M, Święch E, Pierzynowski SG, and Goncharova K

Subjects
Administration, Oral, Animals, Disease Models, Animal, Hyperuricemia complications, Hyperuricemia urine, Intestinal Mucosa metabolism, Male, Nephrectomy, Renal Insufficiency, Chronic blood, Renal Insufficiency, Chronic complications, Renal Insufficiency, Chronic urine, Sus scrofa, Uric Acid urine, Hyperuricemia blood, Hyperuricemia drug therapy, Urate Oxidase administration & dosage, Urate Oxidase therapeutic use, Uric Acid blood
Abstract

An elevated level of serum uric acid-hyperuricemia, is strongly associated with the development of gout and chronic kidney disease (CKD) which is often accompanied by a significantly reduced glomerular filtration rate (GFR). In the present study, we investigated the extra-renal elimination of uric acid via the intestine in a healthy pig model and the effect of oral uricase therapy on plasma uric acid concentrations in pigs with induced hyperuricemia and CKD. The experiment was conducted on eleven, ten-week-old pigs (n = 11). The porcine model of CKD was developed by performing 9/10 nephrectomy surgery on eight pigs. A stable model of hyperuricemia was established in only five of the eight nephrectomized pigs by frequent injections of uric acid (UA) into the jugular vein. All pigs (three healthy pigs and five CKD pigs) were operated for implantation of jugular vein catheters and the three healthy pigs also had portal vein catheters inserted. Blood uric acid concentrations were measured spectrophotometrically, using the Uric Acid Assay Kit (BioAssay Systems, Hayward, USA). The piglets with CKD received orally administered uricase (treatment) and served as their own controls (without uricase supplementation). Oral uricase therapy significantly decreased plasma uric acid concentrations in pigs with CKD, whereas hyperuricemia was observed in the pigs whilst not being treated with uricase. Urinary uric acid excretion was similar during both the treatment and control periods during the first 8 h and 24 h after UA infusions in the CKD pigs. To demonstrate the elimination of UA via the intestine, the healthy pigs were infused with UA into the jugular vein. The blood collected from the jugular vein represents circulating UA concentrations and the blood collected from the portal vein represents the concentration of UA leaving the intestine. The final (after 2 h) concentration of UA was significantly lower in blood collected from the portal vein compared to that collected from the jugular vein (3.34 vs. 2.43 mg/dL, respectively, p = 0.024). The latter allows us to suggest that UA is eliminated from the blood via the gut tissue.

Published
2017
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17. A piglet with surgically induced exocrine pancreatic insufficiency as an animal model of newborns to study fat digestion.

Author

Goncharova K, Pierzynowski SG, Grujic D, Kirko S, Szwiec K, Wang J, Kovalenko T, Osadchenko I, Ushakova G, Shmigel H, Fedkiv O, Majda B, and Prykhodko O

Subjects
Animals, Body Weight, Exocrine Pancreatic Insufficiency etiology, Fatty Acids, Omega-3 metabolism, Fatty Acids, Omega-6 metabolism, Feces, Gastrointestinal Tract metabolism, Growth, Humans, Infant, Newborn, Ligation, Lipase pharmacology, Lipid Metabolism, Male, Milk, Pancreas, Exocrine, Pancreatic Ducts surgery, Random Allocation, Swine, Dietary Fats, Unsaturated metabolism, Digestion, Disease Models, Animal, Exocrine Pancreatic Insufficiency metabolism, Infant Formula, Intestinal Absorption, Lipase deficiency
Abstract

The maldigestion and malabsorption of fat in infants fed milk formula results due to the minimal production of pancreatic lipase. Thus, to investigate lipid digestion and absorption and mimic the situation in newborns, a young porcine exocrine pancreatic insufficient (EPI) model was adapted and validated in the present study. A total of thirteen EPI pigs, aged 8 weeks old, were randomised into three groups and fed either a milk-based formula or a milk-based formula supplemented with either bacterial or fungal lipase. Digestion and absorption of fat was directly correlated with the addition of lipases as demonstrated by a 30% increase in the coefficient of fat absorption. In comparison to the control group, a 40 and 25% reduction in total fat content and 26 and 45% reduction in n-3 and n-6 fatty acid (FA) content in the stool was observed for lipases 1 and 2, respectively. Improved fat absorption was reflected in the blood levels of lipid parameters. During the experiment, only a very slight gain in body weight was observed in EPI piglets, which can be explained by the absence of pancreatic protease and amylase in the gastrointestinal tract. This is similar to newborn babies that have reduced physiological function of exocrine pancreas. In conclusion, we postulate that the EPI pig model fed with infant formula mimics the growth and lipid digestion and absorption in human neonates and can be used to elucidate further importance of fat and FA in the development and growth of newborns, as well as for testing novel formula compositions.

Published
2014
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