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14. Suicide risk among residents and PhD students: A systematic review of the literature

Author

Poli, M, Russotto, S, Fornaro, M, Gonda, X, Lopez-Castroman, J, Madeddu, F, Zeppegno, P, Gramaglia, C, Calati, R, Marianna Poli, Sophia Russotto, Michele Fornaro, Xenia Gonda, Jorge Lopez-Castroman, Fabio Madeddu, Patrizia Zeppegno, Carla Gramaglia, Raffaella Calati, Poli, M, Russotto, S, Fornaro, M, Gonda, X, Lopez-Castroman, J, Madeddu, F, Zeppegno, P, Gramaglia, C, Calati, R, Marianna Poli, Sophia Russotto, Michele Fornaro, Xenia Gonda, Jorge Lopez-Castroman, Fabio Madeddu, Patrizia Zeppegno, Carla Gramaglia, and Raffaella Calati

Published
2023

16. Changes in sleep patterns and the doom-scrolling (doom-surfing) phenomenon as modifiable risk factors for anxiety due to continuous stress of the COVID-19 pandemic

Author

Syunyakov, T.S., primary, Zakharov, A.V., additional, Gayduk, A.J., additional, Ignatenko, J.S., additional, Kuvshinova, N.Y., additional, Pavlichenko, A.V., additional, Spikina, A.A., additional, Fedotov, I.A., additional, Yashikhina, A.A., additional, Gonda, X., additional, Desousa, A., additional, Fountoulakis, K.N., additional, and Smirnova, D.A., additional

Published
2023
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17. Psychological immunity in psychiatry: validation of the mental health test in a psychiatric sample

Author

Gonda, X., primary, Zábó, V., additional, Purebl, G., additional, Erát, D., additional, Harangozó, J., additional, Pongrácz, F., additional, Nagy, E., additional, Bognár, J., additional, Iváncsics, M., additional, Vincze, Á., additional, Farkas, J., additional, Balogh, G., additional, Cowden, R.G., additional, Kéri, S., additional, Patkó, D., additional, Oláh, A., additional, and Vargha, A., additional

Published
2023
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20. Psychological immune competence-based resources in a psychiatric sample – preliminary results of an ongoing research

Author

Pongrácz, F., primary, Bognár, J., additional, Nagy, E., additional, Gonda, X., additional, Zábó, V., additional, Harangozó, J., additional, Erát, D., additional, Iváncsics, M., additional, Vincze, Á., additional, Farkas, J., additional, Balogh, G., additional, Cowden, R.G., additional, Kéri, S., additional, Vargha, A., additional, and Purebl, G., additional

Published
2023
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30. Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression

Author

Culverhouse, R C, Saccone, N L, Horton, A C, Ma, Y, Anstey, K J, Banaschewski, T, Burmeister, M, Cohen-Woods, S, Etain, B, Fisher, H L, Goldman, N, Guillaume, S, Horwood, J, Juhasz, G, Lester, K J, Mandelli, L, Middeldorp, C M, Olié, E, Villafuerte, S, Air, T M, Araya, R, Bowes, L, Burns, R, Byrne, E M, Coffey, C, Coventry, W L, Gawronski, K AB, Glei, D, Hatzimanolis, A, Hottenga, J-J, Jaussent, I, Jawahar, C, Jennen-Steinmetz, C, Kramer, J R, Lajnef, M, Little, K, zu Schwabedissen, H M, Nauck, M, Nederhof, E, Petschner, P, Peyrot, W J, Schwahn, C, Sinnamon, G, Stacey, D, Tian, Y, Toben, C, Van der Auwera, S, Wainwright, N, Wang, J-C, Willemsen, G, Anderson, I M, Arolt, V, Åslund, C, Bagdy, G, Baune, B T, Bellivier, F, Boomsma, D I, Courtet, P, Dannlowski, U, de Geus, E JC, Deakin, J FW, Easteal, S, Eley, T, Fergusson, D M, Goate, A M, Gonda, X, Grabe, H J, Holzman, C, Johnson, E O, Kennedy, M, Laucht, M, Martin, N G, Munafò, M R, Nilsson, K W, Oldehinkel, A J, Olsson, C A, Ormel, J, Otte, C, Patton, G C, Penninx, B WJH, Ritchie, K, Sarchiapone, M, Scheid, J M, Serretti, A, Smit, J H, Stefanis, N C, Surtees, P G, Völzke, H, Weinstein, M, Whooley, M, Nurnberger, J I, Jr, Breslau, N, and Bierut, L J

Published
2018
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34. Results of the COVID-19 mental health international for the general population (COMET-G) study

Author

Fountoulakis, KN, Karakatsoulis, G, Abraham, S, Adorjan, K, Ahmed, HU, Alarcón, RD, Arai, K, Auwal, SS, Berk, Michael, Bjedov, S, Bobes, J, Bobes-Bascaran, T, Bourgin-Duchesnay, J, Bredicean, CA, Bukelskis, L, Burkadze, A, Abud, IIC, Castilla-Puentes, R, Cetkovich, M, Colon-Rivera, H, Corral, R, Cortez-Vergara, C, Crepin, P, De Berardis, D, Zamora Delgado, S, De Lucena, D, De Sousa, A, Stefano, RD, Dodd, Seetal, Elek, LP, Elissa, A, Erdelyi-Hamza, B, Erzin, G, Etchevers, MJ, Falkai, P, Farcas, A, Fedotov, I, Filatova, V, Fountoulakis, NK, Frankova, I, Franza, F, Frias, P, Galako, T, Garay, CJ, Garcia-Álvarez, L, García-Portilla, MP, Gonda, X, Gondek, TM, González, DM, Gould, H, Grandinetti, P, Grau, A, Groudeva, V, Hagin, M, Harada, T, Hasan, TM, Hashim, NA, Hilbig, J, Hossain, S, Iakimova, R, Ibrahim, M, Iftene, F, Ignatenko, Y, Irarrazaval, M, Ismail, Z, Ismayilova, J, Jakobs, A, Jakovljević, M, Jakšić, N, Javed, A, Kafali, HY, Karia, S, Kazakova, O, Khalifa, D, Khaustova, O, Koh, S, Kopishinskaia, S, Kosenko, K, Koupidis, SA, Kovacs, I, Kulig, B, Lalljee, A, Liewig, J, Majid, A, Malashonkova, E, Malik, K, Malik, NI, Mammadzada, G, Mandalia, B, Marazziti, D, Marčinko, D, Martinez, S, Matiekus, E, Mejia, G, Memon, RS, Martínez, XEM, Mickevičiūtė, D, Milev, R, Mohammed, M, Molina-López, A, Fountoulakis, KN, Karakatsoulis, G, Abraham, S, Adorjan, K, Ahmed, HU, Alarcón, RD, Arai, K, Auwal, SS, Berk, Michael, Bjedov, S, Bobes, J, Bobes-Bascaran, T, Bourgin-Duchesnay, J, Bredicean, CA, Bukelskis, L, Burkadze, A, Abud, IIC, Castilla-Puentes, R, Cetkovich, M, Colon-Rivera, H, Corral, R, Cortez-Vergara, C, Crepin, P, De Berardis, D, Zamora Delgado, S, De Lucena, D, De Sousa, A, Stefano, RD, Dodd, Seetal, Elek, LP, Elissa, A, Erdelyi-Hamza, B, Erzin, G, Etchevers, MJ, Falkai, P, Farcas, A, Fedotov, I, Filatova, V, Fountoulakis, NK, Frankova, I, Franza, F, Frias, P, Galako, T, Garay, CJ, Garcia-Álvarez, L, García-Portilla, MP, Gonda, X, Gondek, TM, González, DM, Gould, H, Grandinetti, P, Grau, A, Groudeva, V, Hagin, M, Harada, T, Hasan, TM, Hashim, NA, Hilbig, J, Hossain, S, Iakimova, R, Ibrahim, M, Iftene, F, Ignatenko, Y, Irarrazaval, M, Ismail, Z, Ismayilova, J, Jakobs, A, Jakovljević, M, Jakšić, N, Javed, A, Kafali, HY, Karia, S, Kazakova, O, Khalifa, D, Khaustova, O, Koh, S, Kopishinskaia, S, Kosenko, K, Koupidis, SA, Kovacs, I, Kulig, B, Lalljee, A, Liewig, J, Majid, A, Malashonkova, E, Malik, K, Malik, NI, Mammadzada, G, Mandalia, B, Marazziti, D, Marčinko, D, Martinez, S, Matiekus, E, Mejia, G, Memon, RS, Martínez, XEM, Mickevičiūtė, D, Milev, R, Mohammed, M, and Molina-López, A

Published
2022

46. Modeling psychological function in patients with schizophrenia with the PANSS: An international multi-center study

Author

Fountoulakis, K.N. Dragioti, E. Theofilidis, A.T. Wiklund, T. Atmatzidis, X. Nimatoudis, I. Thys, E. Wampers, M. Hranov, L. Hristova, T. Aptalidis, D. Milev, R. Iftene, F. Spaniel, F. Knytl, P. Furstova, P. From, T. Karlsson, H. Walta, M. Salokangas, R.K.R. Azorin, J.-M. Bouniard, J. Montant, J. Juckel, G. Haussleiter, I.S. Douzenis, A. Michopoulos, I. Ferentinos, P. Smyrnis, N. Mantonakis, L. Nemes, Z. Gonda, X. Vajda, D. Juhasz, A. Shrivastava, A. Waddington, J. Pompili, M. Comparelli, A. Corigliano, V. Rancans, E. Navickas, A. Hilbig, J. Bukelskis, L. Stevovic, L.I. Vodopic, S. Esan, O. Oladele, O. Osunbote, C. Rybakowski, J.K. Wojciak, P. Domowicz, K. Figueira, M.L. Linhares, L. Crawford, J. Panfil, A.-L. Smirnova, D. Izmailova, O. Lecic-Tosevski, D. Temmingh, H. Howells, F. Bobes, J. Garcia-Portilla, M.P. García-Alvarez, L. Erzin, G. Karadaǧ, H. De Sousa, A. Bendre, A. Hoschl, C. Bredicean, C. Papava, I. Vukovic, O. Pejuskovic, B. Russell, V. Athanasiadis, L. Konsta, A. Stein, D. Berk, M. Dean, O. Tandon, R. Kasper, S. De Hert, M.

Abstract

Background The aim of the current study was to explore the changing interrelationships among clinical variables through the stages of schizophrenia in order to assemble a comprehensive and meaningful disease model. Methods Twenty-nine centers from 25 countries participated and included 2358 patients aged 37.21 ±Â 11.87 years with schizophrenia. Multiple linear regression analysis and visual inspection of plots were performed. Results The results suggest that with progression stages, there are changing correlations among Positive and Negative Syndrome Scale factors at each stage and each factor correlates with all the others in that particular stage, in which this factor is dominant. This internal structure further supports the validity of an already proposed four stages model, with positive symptoms dominating the first stage, excitement/hostility the second, depression the third, and neurocognitive decline the last stage. Conclusions The current study investigated the mental organization and functioning in patients with schizophrenia in relation to different stages of illness progression. It revealed two distinct cores of schizophrenia, the Positive and the Negative, while neurocognitive decline escalates during the later stages. Future research should focus on the therapeutic implications of such a model. Stopping the progress of the illness could demand to stop the succession of stages. This could be achieved not only by both halting the triggering effect of positive and negative symptoms, but also by stopping the sensitization effect on the neural pathways responsible for the development of hostility, excitement, anxiety, and depression as well as the deleterious effect on neural networks responsible for neurocognition. © 2021 Cambridge University Press. All rights reserved.

Published
2021

47. Gender, age at onset, and duration of being ill as predictors for the long-term course and outcome of schizophrenia: an international multicenter study

Author

Fountoulakis, KN, Dragioti, E, Theofilidis, AT, Wiklund, T, Atmatzidis, X, Nimatoudis, I, Thys, E, Wampers, M, Hranov, L, Hristova, T, Aptalidis, D, Milev, R, Iftene, F, Spaniel, F, Knytl, P, Furstova, P, From, T, Karlsson, H, Walta, M, Salokangas, RKR, Azorin, J-M, Bouniard, J, Montant, J, Juckel, G, Haussleiter, IS, Douzenis, A, Michopoulos, I, Ferentinos, P, Smyrnis, N, Mantonakis, L, Nemes, Z, Gonda, X, Vajda, D, Juhasz, A, Shrivastava, A, Waddington, J, Pompili, M, Comparelli, A, Corigliano, V, Rancans, E, Navickas, A, Hilbig, J, Bukelskis, L, Stevovic, LI, Vodopic, S, Esan, O, Oladele, O, Osunbote, C, Rybakowski, JK, Wojciak, P, Domowicz, K, Figueira, ML, Linhares, L, Crawford, J, Panfil, A-L, Smirnova, D, Izmailova, O, Lecic-Tosevski, D, Temmingh, H, Howells, F, Bobes, J, Garcia-Portilla, MP, Garcia-Alvarez, L, Erzin, G, Karadag, H, De Sousa, A, Bendre, A, Hoschl, C, Bredicean, C, Papava, I, Vukovic, O, Pejuskovic, B, Russell, V, Athanasiadis, L, Konsta, A, Fountoulakis, NK, Stein, D, Berk, M, Dean, O, Tandon, R, Kasper, S, De Hert, M, Fountoulakis, KN, Dragioti, E, Theofilidis, AT, Wiklund, T, Atmatzidis, X, Nimatoudis, I, Thys, E, Wampers, M, Hranov, L, Hristova, T, Aptalidis, D, Milev, R, Iftene, F, Spaniel, F, Knytl, P, Furstova, P, From, T, Karlsson, H, Walta, M, Salokangas, RKR, Azorin, J-M, Bouniard, J, Montant, J, Juckel, G, Haussleiter, IS, Douzenis, A, Michopoulos, I, Ferentinos, P, Smyrnis, N, Mantonakis, L, Nemes, Z, Gonda, X, Vajda, D, Juhasz, A, Shrivastava, A, Waddington, J, Pompili, M, Comparelli, A, Corigliano, V, Rancans, E, Navickas, A, Hilbig, J, Bukelskis, L, Stevovic, LI, Vodopic, S, Esan, O, Oladele, O, Osunbote, C, Rybakowski, JK, Wojciak, P, Domowicz, K, Figueira, ML, Linhares, L, Crawford, J, Panfil, A-L, Smirnova, D, Izmailova, O, Lecic-Tosevski, D, Temmingh, H, Howells, F, Bobes, J, Garcia-Portilla, MP, Garcia-Alvarez, L, Erzin, G, Karadag, H, De Sousa, A, Bendre, A, Hoschl, C, Bredicean, C, Papava, I, Vukovic, O, Pejuskovic, B, Russell, V, Athanasiadis, L, Konsta, A, Fountoulakis, NK, Stein, D, Berk, M, Dean, O, Tandon, R, Kasper, S, and De Hert, M

Abstract

BACKGROUND: The aim of the current study was to explore the effect of gender, age at onset, and duration on the long-term course of schizophrenia. METHODS: Twenty-nine centers from 25 countries representing all continents participated in the study that included 2358 patients aged 37.21 ± 11.87 years with a DSM-IV or DSM-5 diagnosis of schizophrenia; the Positive and Negative Syndrome Scale as well as relevant clinicodemographic data were gathered. Analysis of variance and analysis of covariance were used, and the methodology corrected for the presence of potentially confounding effects. RESULTS: There was a 3-year later age at onset for females (P < .001) and lower rates of negative symptoms (P < .01) and higher depression/anxiety measures (P < .05) at some stages. The age at onset manifested a distribution with a single peak for both genders with a tendency of patients with younger onset having slower advancement through illness stages (P = .001). No significant effects were found concerning duration of illness. DISCUSSION: Our results confirmed a later onset and a possibly more benign course and outcome in females. Age at onset manifested a single peak in both genders, and surprisingly, earlier onset was related to a slower progression of the illness. No effect of duration has been detected. These results are partially in accord with the literature, but they also differ as a consequence of the different starting point of our methodology (a novel staging model), which in our opinion precluded the impact of confounding effects. Future research should focus on the therapeutic policy and implications of these results in more representative samples.

Published
2021

48. Modeling psychological function in patients with schizophrenia with the PANSS : An international multi-center study

Author

Fountoulakis, K.N., Dragioti, Elena, Theofilidis, A.T., Wiklund, Tobias, Atmatzidis, Xenofon, Nimatoudis, I., Thys, E., Wampers, M., Hranov, L., Hristova, T., Aptalidis, D., Milev, R., Iftene, F., Spaniel, F., Knytl, P., Furstova, P., From, T., Karlsson, H., Walta, M., Salokangas, R.K.R., Azorin, J.-M., Bouniard, J., Montant, J., Juckel, G., Haussleiter, I.S., Douzenis, A., Michopoulos, I., Ferentinos, P., Smyrnis, N., Mantonakis, L., Nemes, Z., Gonda, X., Vajda, D., Juhasz, A., Shrivastava, A., Waddington, J., Pompili, M., Comparelli, A., Corigliano, V., Rancans, E., Navickas, A., Hilbig, J., Bukelskis, L., Stevovic, L.I., Vodopic, S., Esan, O., Oladele, O., Osunbote, C., Rybakowski, J.K., Wojciak, P., Domowicz, K., Figueira, M.L., Linhares, L., Crawford, J., Panfil, A.-L., Smirnova, D., Izmailova, O., Lecic-Tosevski, D., Temmingh, H., Howells, F., Bobes, J., Garcia-Portilla, M.P., Garciá-Alvarez, L., Erzin, G., Karada, H., De, Sousa A., Bendre, A., Hoschl, C., Bredicean, C., Papava, I., Vukovic, O., Pejuskovic, B., Russell, V., Athanasiadis, L., Konsta, A., Stein, D., Berk, M., Dean, O., Tandon, R., Kasper, S., De, Hert M., Fountoulakis, K.N., Dragioti, Elena, Theofilidis, A.T., Wiklund, Tobias, Atmatzidis, Xenofon, Nimatoudis, I., Thys, E., Wampers, M., Hranov, L., Hristova, T., Aptalidis, D., Milev, R., Iftene, F., Spaniel, F., Knytl, P., Furstova, P., From, T., Karlsson, H., Walta, M., Salokangas, R.K.R., Azorin, J.-M., Bouniard, J., Montant, J., Juckel, G., Haussleiter, I.S., Douzenis, A., Michopoulos, I., Ferentinos, P., Smyrnis, N., Mantonakis, L., Nemes, Z., Gonda, X., Vajda, D., Juhasz, A., Shrivastava, A., Waddington, J., Pompili, M., Comparelli, A., Corigliano, V., Rancans, E., Navickas, A., Hilbig, J., Bukelskis, L., Stevovic, L.I., Vodopic, S., Esan, O., Oladele, O., Osunbote, C., Rybakowski, J.K., Wojciak, P., Domowicz, K., Figueira, M.L., Linhares, L., Crawford, J., Panfil, A.-L., Smirnova, D., Izmailova, O., Lecic-Tosevski, D., Temmingh, H., Howells, F., Bobes, J., Garcia-Portilla, M.P., Garciá-Alvarez, L., Erzin, G., Karada, H., De, Sousa A., Bendre, A., Hoschl, C., Bredicean, C., Papava, I., Vukovic, O., Pejuskovic, B., Russell, V., Athanasiadis, L., Konsta, A., Stein, D., Berk, M., Dean, O., Tandon, R., Kasper, S., and De, Hert M.

Abstract

Background. The aim of the current study was to explore the changing interrelationships among clinical variables through the stages of schizophrenia in order to assemble a comprehensive and meaningful disease model. Methods. Twenty-nine centers from 25 countries participated and included 2358 patients aged 37.21 ± 11.87 years with schizophrenia. Multiple linear regression analysis and visual inspection of plots were performed. Results. The results suggest that with progression stages, there are changing correlations among Positive and Negative Syndrome Scale factors at each stage and each factor correlates with all the others in that particular stage, in which this factor is dominant. This internal structure further supports the validity of an already proposed four stages model, with positive symptoms dominating the first stage, excitement/hostility the second, depression the third, and neurocognitive decline the last stage. Conclusions. The current study investigated the mental organization and functioning in patients with schizophrenia in relation to different stages of illness progression. It revealed two distinct “cores” of schizophrenia, the “Positive” and the “Negative,” while neurocognitive decline escalates during the later stages. Future research should focus on the therapeutic implications of such a model. Stopping the progress of the illness could demand to stop the succession of stages. This could be achieved not only by both halting the triggering effect of positive and negative symptoms, but also by stopping the sensitization effect on the neural pathways responsible for the development of hostility, excitement, anxiety, and depression as well as the deleterious effect on neural networks responsible for neurocognition.

Published
2021
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