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2. A Systematic Approach to the Evaluation of the Coronary Microcirculation Using Bolus Thermodilution: CATH CMD

Author

Collet, Carlos, Yong, Andy, Munhoz, Daniel, Akasaka, Takashi, Berry, Colin, Blair, John E.A., Collison, Damien, Engstrøm, Thomas, Escaned, Javier, Fearon, William F., Ford, Tom, Gori, Tommaso, Koo, Bon-Kwon, Low, Adrian F, Miner, Steve, Ng, Martin K.C., Mizukami, Takuya, Shimokawa, Hiroki, Smilowitz, Nathaniel R., Sutton, Nadia R., Svanerud, Johan, Tremmel, Jennifer A., Warisawa, Takayuki, West, Nick E.J., and Ali, Ziad A.

Published
2024
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6. Quality of life of patients with coronary heart disease treated with the bioresorbable vascular scaffold (ABSORB™): 2-year results from the GABI-R-registry

Author

Pahmeier, Kathrin, Neusser, Silke, Hamm, Christian, Kastner, Johannes, Wöhrle, Jochen, Zahn, Ralf, Achenbach, Stephan, Mehilli, Julinda, Gori, Tommaso, Naber, Christoph, Nef, Holger, Neumann, Till, Richardt, Gert, Schmermund, Axel, Claas, Christoph, Riemer, Thomas, and Biermann-Stallwitz, Janine

Published
2022
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7. Telemedical cardiac risk assessment by implantable cardiac monitors in patients after myocardial infarction with autonomic dysfunction (SMART-MI-DZHK9): a prospective investigator-initiated, randomised, multicentre, open-label, diagnostic trial

Author

May, Andreas, Seitzer, Peter, Schmidt, Roland, Keta, Dritan, Janke, Viktoria, Schläger, Christian, André, Elisabeth, Brandt, Niels, Schön, Alexandra, Zollner, Alfred, Freyer, Luisa, Hamm, Wolfgang, Beil, Johannes, Strüven, Anna Katharina, Loew, Anja, Fichtner, Stephanie, Lange, Philipp, Krasniqi, Aresa, Grabmeier, Ulrich, Estner, Heidi, Bengel, Philipp, Lüthje, Lars, Kirova, Aleksandra, Fischer, Thomas, Bergau, Leonard, Herting, Jonas, Schlögl, Simon, Haarmann, Helge, Schlögl (Illes), Klaudia, Uecer, Ekrem, Sag, Sabine, Tafelmeier, Maria, Jungbauer, Carsten, Fredersdorf-Hahn, Sabine, Strack, Christina, Seither, Benedikt, Seegers, Joachim, Millenaar, Dominic, Wintrich, Jan, Fischer, Patrick, Buob, Axel, Razouk, Amjad, Demming, Thomas, Frank, Johanne, Kühl, Constantin, Ellendt, Ulrike, Sandrock, Sarah, Gänsbacher, Julia, Cupa, Janosch, Sinnecker, Daniel, Laugwitz, Karl-Ludwig, Steger, Alexander, Berkefeld, Anna, Schinke, Karin, Barthel, Petra, Dommasch, Michael, Amadei, Maiwand, Hindricks, Gerhard, Obradovic, Danilo, Döring, Michael, Bode, Kerstin, Hilbert, Sebastian, Löbe, Susanne, Knopp, Helge, König, Sebastian, John, Silke, Schöne, Katharina, Hartung, Philipp, Binner, Christian, Meyer-Zürn, Christine, Duckheim, Martin, Eick, Christian, Simpfle, Fabian, Schreieck, Jürgen, Mizera, Lars, Tscholl, Verena, Steinbeck, Lisa, Güc, Nadija, Schatz, Anne-Sophie, Attanasio, Philipp, Heuberger, Andrea, Roser, Mattias, Bellmann, Barbara, Nagel, Patrick, Biewener, Sebastian, Suhail, Saba, Juri, Benjamin, Meyer, Christian, Wiilems, Stephan, Jungen, Christiane, Schmitt, Susanne, Münkerer, Paula, Vogler, Julia, Kaiser, Lukas, Schäffer, Benjamin, Nies, Moritz, Tönnis, Tobias, Fluschnik, Nina, Grahn, Hanno, Waldeyer, Christoph, Kany, Shinwan, Sörensen, Nils Arne, Winkelmann, Simon, Akbulak, Özge, Gosau, Nils Arne, Würger, Tilman, Arnold, Natalie, Geßler, Nele, Jobs, Alexander, Münkler, Paula, Rausch, Stefan, Köster, Jelena, Brüggemann, Ben, Abdin, Amr, Wacker, Christian, Grotherr, Philipp, Fries, Bastian, Faust, Maximilian, Steuer, Stefanie, Swojanowsky, Patrick, Willems, Stephan, Portz, Nathaniel, Ujeyl, Amar, Krüger, Matthias, Gramlich, Robert, Köhler, Till, Sause, Armin, Nover, Ina, Ziakos, Athanasios-Panagiotis, Ciobanu, Veaceslav, Spelsberg, Norman, Siebermair, Johannes, Mahabadi, Amir-Abbas, Köhler, Miriam, Vonderlin, Nadine, Riesinger, Lisa, Abdiu, Edison, Bachmann, Anja, Frenzel, Marie, Hummel, Astrid, Lehnert, Kristin, Krüger, Anne, Busse, Franke, Napp, Andreas, Müller-Wieland, Dirk, Battermann, Simone, Lacour, Philipp, Trippel, Tobias, Beetz, Nick Lasse, Schleußner, Leonhard, Zach, Veronika, Rozados, Christina, Mudra, Harald, Staubach, Stephan, Illmann, Alexander, Joner, Michael, Bock, Matthias, Kolb, Christof, Koch, Tobias, Fröhlich, Rebecca, Lennerz, Carsten, Lenz, Tobias, Fuchs, Patrick, Freißmuth, Markus, Grebmer, Christian, Kuschyk, Jürgen, Kranert, Malte, Fastenrath, Fabian, Yücel, Gökhan, Rudic, Boris, Würfel, Sarah, Römer, Albrecht, Böhmer, Andreas, Honold, Jörg, Georgopoulos, Stamatis, Gleirscher, Lukas, Lederle, Susanne, Chaplygin, Artem, Pauschinger, Matthias, Brinker-Paschke, Andrea, Kropacek, Jana, Eckardt, Lars, Ellermann, Christian, Bode, Niklas, Reinke, Florian, Engelke, Hauke, Höllriegel, Robert, Woitek, Felix, Winzer, Ephraim, Ibrahim, Karim, Pflücke, Christian, Ende, Georg, Speiser, Uwe, Haußig, Stephan, Wachter, Rolf, Uhe, Tobias, Konrad, Torsten, Zitron, Edgar, Destani, Jeton, Fu, Fangyi, Al Said, Samer, Kaya, Ziya, Schgör, Wilfried, Senoner, Thomas, Bauer, Axel, Sappler, Nikolay, von Stülpnagel, Lukas, Klemm, Mathias, Schreinlechner, Michael, Wenner, Felix, Schier, Johannes, Al Tawil, Amani, Dolejsi, Theresa, Eiffener, Elodie, Bongarth, Christa, Stühlinger, Markus, Huemer, Martin, Gori, Tommaso, Wakili, Reza, Sahin, Riza, Schwinger, Robert, Lutz, Matthias, Luik, Armin, Gessler, Nele, Clemmensen, Peter, Linke, Axel, Maier, Lars S, Hinterseer, Martin, Busch, Mathias C, Blaschke, Florian, Sack, Stefan, Licka, Manuela, Tilz, Roland R, Ukena, Christian, Ehrlich, Joachim R, Zabel, Markus, Schmidt, Georg, Mansmann, Ulrich, Kääb, Stefan, Rizas, Konstantinos D, and Massberg, Steffen

Published
2022
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9. Targeting myeloid cell coagulation signaling blocks MAP kinase/TGF-[beta]1- driven fibrotic remodeling in ischemic heart failure

Author

Garlapati, Venkata, Molitor, Michael, Michna, Thomas, Harms, Gregory S., Finger, Stefanie, Jung, Rebecca, Lagrange, Jeremy, Efentakis, Panagiotis, Wild, Johannes, Knorr, Maike, Karbach, Susanne, Wild, Sabine, Vujacic-Mirski, Ksenija, Munzel, Thomas, Daiber, Andreas, Brandt, Moritz, Gori, Tommaso, Milting, Hendrik, Tenzer, Stefan, Ruf, Wolfram, and Wenzel, Philip

Subjects
Fibrosis -- Development and progression -- Drug therapy, Bone marrow cells -- Health aspects, Cardiovascular research, Cellular signal transduction -- Research, Transforming growth factors -- Health aspects, Coagulation -- Research, Mitogen-activated protein kinases -- Health aspects, Myocardial ischemia -- Development and progression -- Drug therapy, Heart failure -- Development and progression -- Drug therapy, Health care industry
Abstract

Despite major advances in acute interventions for myocardial infarction (MI), adverse cardiac remodeling and excess fibrosis after MI causing ischemic heart failure (IHF) remain a leading cause of death worldwide. Here we identify a profibrotic coagulation signaling pathway that can be targeted for improved cardiac function following MI with persistent ischemia. Quantitative phosphoproteomics of cardiac tissue revealed an upregulated mitogen-activated protein kinase (MAPK) pathway in human IHF. Intervention in this pathway with trametinib improves myocardial function and prevents fibrotic remodeling in a murine model of non-reperfused MI. MAPK activation in MI requires myeloid cell signaling of protease-activated receptor 2 linked to the cytoplasmic domain of the coagulation initiator tissue factor (TF). They act upstream of pro-oxidant NOX2 NADPH oxidase, ERK1/2 phosphorylation, and activation of profibrotic TGF-[beta]1. Specific targeting with the TF inhibitor nematode anticoagulant protein c2 (NAPc2) starting 1 day after established experimental MI averts IHF. Increased TF cytoplasmic domain phosphorylation in circulating monocytes from patients with subacute MI identifies a potential thromboinflammatory biomarker reflective of increased risk for IHF and suitable for patient selection to receive targeted TF inhibition therapy., Introduction Proper wound healing depends on effective hemostasis, which allows regeneration and reconstitution of defective tissue function (1). Coronary thrombosis causing myocardial infarction (MI) (2) leads to irreversible tissue injury, [...]

Published
2023
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10. Incidence and predictors of 2-year mortality following percutaneous left atrial appendage occlusion in the EWOLUTION trial.

Author

Aarnink, Errol W, Ince, Hueseyin, Kische, Stephan, Pokushalov, Evgeny, Schmitz, Thomas, Schmidt, Boris, Gori, Tommaso, Meincke, Felix, Protopopov, Alexey Vladimir, Betts, Timothy, Mazzone, Patrizio, Grygier, Marek, Sievert, Horst, Potter, Tom De, Vireca, Elisa, Stein, Kenneth, Bergmann, Martin W, and Boersma, Lucas V A

Abstract

Aims Sufficient survival time following left atrial appendage occlusion (LAAO) is essential for ensuring the efficacy and cost-effectiveness of this strategy for stroke prevention. Understanding prognostic factors for early mortality after LAAO could optimize patient selection. In the current study, we perform an in-depth analysis of 2-year mortality after LAAO, focusing particularly on potential predictors. Methods and results The EWOLUTION registry is a real-world cohort comprising 1020 patients that underwent LAAO. Endpoint definitions were pre-specified, and death was categorized as cardiovascular, non-cardiovascular, or unknown origin. Mortality rates were calculated from Kaplan–Meier estimates. Baseline characteristics significantly associated with death in univariate Cox regression analysis were incorporated into the multivariate analysis. All multivariate predictors were included in a risk model. Two-year mortality rate was 16.4% [confidence interval (CI): 14.0–18.7%], with 50% of patients dying from a non-cardiovascular cause. Multivariate baseline predictors of 2-year mortality included age [hazard ratio (HR) 1.05, CI: 1.03–1.08, per year increase], heart failure (HR 1.73, CI: 1.24–2.41), vascular disease (HR 1.47, CI: 1.05–2.05), valvular disease (HR 1.63, CI: 1.15–2.33), abnormal liver function (HR 1.80, CI: 1.02–3.17), and abnormal renal function (HR 1.58, CI: 1.10–2.27). Mortality rate exhibited a gradual rise as the number of risk factors increased, reaching 46.1% in patients presenting with five or six risk factors. Conclusion One in six patients died within 2 years after LAAO. We identified six independent predictors of mortality. When combined, this model showed a gradual increase in mortality rate with a growing number of risk factors, which may guide appropriate patient selection for LAAO. Clinical trial registration The original EWOLUTION registry was registered at clinicaltrials.gov under identifier NCT01972282. [ABSTRACT FROM AUTHOR]

Published
2024
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16. A nationwide trend analysis on the usage of endomyocardial biopsy.

Author

Keller, Karsten, Göbel, Sebastian, Gori, Tommaso, Münzel, Thomas, Wenzel, Philip, and Hobohm, Lukas

Subjects
TREND analysis, BIOPSY, ODDS ratio, CONFIDENCE intervals, STRESS echocardiography
Abstract

Background: Endomyocardial biopsy (EMB) is a safe procedure performed in diagnostic work‐up of cardiac disease. Hypothesis: Data regarding temporal trends of total numbers, characteristics, in‐hospital outcomes, and complications of patients undergoing EMB are sparse. Methods: The nationwide German inpatient sample (2005–2019) was used for this analysis. Patient cases of EBM during the 5‐year cycles from 2005 to 2009, 2010 to 2014, and 2015 to 2019 were compared, and temporal trends regarding total numbers and presumable major and minor EMB‐associated complications were investigated. Results: Overall, 67 745 EMB were performed in Germany 2005–2019. Total number of EMB increased from 3083 in 2005 to 5646 in 2019 (β 0.40 [95% confidence interval [CI] 0.37–0.43], p <.001). Among these EMB, 19 083 (28.2%) were performed during the period 2005–2009, 22 867 (33.7%) 2010–2014, and 25 795 (38.1%) between 2015 and 2019. The proportion of patients aged ≥70 years was highest 2015–2019 (2005–2009: 9.3%; 2010–2014: 13.8%; 2015–2019: 16.1%, p <.001) and the most aggravated comorbidity profile (Charlson Comorbidity Index 2.25 ± 1.93; 2.67 ± 2.14; 3.01 ± 2.29, p <.001) was also detected 2015–2019. Major complications occurred less often in the period 2015–2019 compared to 2005–2009 (odds ratio [OR] 0.921 [95% CI 0.893–0.950], p <.001), whereas minor complications were more frequently observed between 2015 and 2019 (OR 1.067 [95% CI 1.042–1.093], p <.001). While a decrease in major complications was detected irrespective of age, an increase in minor complications was identified only in patients between 30–59 years. Conclusions: Annual numbers of EMB increased significantly in Germany 2005–2019. Patients who underwent EMB in recent years were older and showed an aggravated comorbidity profile accompanied by fewer major complications, underscoring safety of the procedure. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Clinical, Angiographic, and Procedural Correlates of Very Late Absorb Scaffold Thrombosis: Multistudy Registry Results

Author

Ellis, Stephen G., Gori, Tommaso, Serruys, Patrick W., Nef, Holger, Steffenino, Giuseppe, Brugaletta, Salvatore, Munzel, Thomas, Feliz, Cordula, Schmidt, Götz, Sabaté, Manel, Onuma, Yoshinobu, van Geuns, R.J., Gao, Run-Lin, Menichelli, Maurizio, Kereiakes, Dean J., Stone, Gregg W., Testa, Luca, Kimura, Takeshi, and Abizaid, Alexandre

Published
2018
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20. Five-Year Clinical Outcomes After Coronary Bioresorbable Scaffolds and Drug-Eluting Stents: The ABSORB IV Randomized Trial

Author

Stone, Gregg W., primary, Kereiakes, Dean J., additional, Gori, Tommaso, additional, Metzger, D. Christopher, additional, Stein, Bernardo, additional, Erickson, Matthew, additional, Torzewski, Jan, additional, Kabour, Ameer, additional, Piegari, Guy, additional, Cavendish, Jeffrey, additional, Bertolet, Barry, additional, Stockelman, Kelly A., additional, West, Nick E.J., additional, Ben-Yehuda, Ori, additional, Choi, James W., additional, Marx, Steven O., additional, Spertus, John A., additional, and Ellis, Stephen G., additional

Published
2023
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24. Bioresorbable Everolimus-Eluting Vascular Scaffold for Long Coronary Lesions: A Subanalysis of the International, Multicenter GHOST-EU Registry

Author

Geraci, Salvatore, Kawamoto, Hiroyoshi, Caramanno, Giuseppe, Ruparelia, Neil, Capodanno, Davide, Brugaletta, Salvatore, Gori, Tommaso, Nef, Holger, Sabate, Manel, Mehilli, Julinda, Lesiak, Maciej, Naber, Christoph, Di Mario, Carlo, Capranzano, Piera, Wiebe, Jens, Araszkiewicz, Aleksander, Pyxaras, Stelios, Mattesini, Alessio, Münzel, Thomas, Tamburino, Corrado, Colombo, Antonio, and Latib, Azeem

Published
2017
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25. Comprehensive vasodilatation in women with acute heart failure: Novel insights from the GALACTIC randomized controlled trial.

Author

Wussler, Desiree, Belkin, Maria, Maeder, Micha T., Walter, Joan, Shrestha, Samyut, Kupska, Karolina, Stierli, Michelle, Flores, Dayana, Kozhuharov, Nikola, Gualandro, Danielle Menosi, de Oliveira Junior, Mucio Tavares, Sabti, Zaid, Noveanu, Markus, Socrates, Thenral, Bayés‐Genis, Antoni, Sionis, Alessandro, Simon, Patrick, Michou, Eleni, Gujer, Samuel, and Gori, Tommaso

Subjects
HEART failure, RANDOMIZED controlled trials, ALDOSTERONE antagonists, VASODILATION, SYSTOLIC blood pressure, HEART failure patients, VENTRICULAR ejection fraction
Abstract

Aims: Sex‐specific differences in acute heart failure (AHF) are both relevant and underappreciated. Therefore, it is crucial to evaluate the risk/benefit ratio and the implementation of novel AHF therapies in women and men separately. Methods and results: We performed a pre‐defined sex‐specific analysis in AHF patients randomized to a strategy of early intensive and sustained vasodilatation versus usual care in an international, multicentre, open‐label, blinded endpoint trial. Inclusion criteria were AHF with increased plasma concentrations of natriuretic peptides, systolic blood pressure ≥100 mmHg, and plan for treatment in a general ward. Among 781 eligible patients, 288 (37%) were women. Women were older (median 83 vs. 76 years), had a lower body weight (median 64.5 vs. 77.6 kg) and lower estimated glomerular filtration rate (median 48 vs. 54 ml/min/1.73 m2). The primary endpoint, a composite of all‐cause mortality or rehospitalization for AHF at 180 days, showed a significant interaction of treatment strategy and sex (p for interaction = 0.03; hazard ratio adjusted for female sex 1.62, 95% confidence interval 1.05–2.50; p = 0.03). The combined endpoint occurred in 53 women (38%) in the intervention group and in 35 (24%) in the usual care group. The implementation of rapid up‐titration of renin–angiotensin–aldosterone system (RAAS) inhibitors was less successful in women versus men in the overall cohort and in patients with heart failure with reduced ejection fraction (median discharge % target dose in patients randomized to intervention: 50% in women vs. 75% in men). Conclusion: Rapid up‐titration of RAAS inhibitors was less successfully implemented in women possibly explaining their higher rate of all‐cause mortality and rehospitalization for AHF. Clinical Trial Registration: ClinicalTrials.gov, unique identifier NCT00512759. [ABSTRACT FROM AUTHOR]

Published
2023
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28. COVID-19 infection and its impact on case-fatality in patients with pulmonary embolism

Author

Hobohm, Lukas; https://orcid.org/0000-0002-4312-0366, Sagoschen, Ingo, Barco, Stefano; https://orcid.org/0000-0002-2618-347X, Farmakis, Ioannis T; https://orcid.org/0000-0002-0586-6386, Fedeli, Ugo, Koelmel, Sebastian, Gori, Tommaso, Espinola-Klein, Christine, Münzel, Thomas, Konstantinides, Stavros; https://orcid.org/0000-0001-6359-7279, Keller, Karsten; https://orcid.org/0000-0002-0820-9584, Hobohm, Lukas; https://orcid.org/0000-0002-4312-0366, Sagoschen, Ingo, Barco, Stefano; https://orcid.org/0000-0002-2618-347X, Farmakis, Ioannis T; https://orcid.org/0000-0002-0586-6386, Fedeli, Ugo, Koelmel, Sebastian, Gori, Tommaso, Espinola-Klein, Christine, Münzel, Thomas, Konstantinides, Stavros; https://orcid.org/0000-0001-6359-7279, and Keller, Karsten; https://orcid.org/0000-0002-0820-9584

Abstract

BACKGROUND Although a high prevalence of pulmonary embolism (PE) has been reported in association with coronavirus disease (COVID)-19 in critically ill patients, nationwide data on the outcome of hospitalised patients with COVID-19 and PE is still limited. Thus, we investigated seasonal trends and predictors of in-hospital death in patients with COVID-19 and PE in Germany. METHODS We used the German nationwide inpatient sample to analyse data on hospitalisations among COVID-19 patients with and without PE during 2020, and to detect changes in PE prevalence and case fatality in comparison to 2019. RESULTS We analysed 176,137 COVID-19 hospitalisations in 2020; PE was recorded in 1.9% (n=3362) of discharge certificates. Almost one third of patients with COVID-19 and PE died during the in-hospital course (28.7%) compared to COVID-19 patients without PE (17.7%). Between 2019 and 2020, numbers of PE-related hospitalisations were largely unchanged (98,485 versus 97,718), whereas the case-fatality rate of PE increased slightly in 2020 (from 12.7% to 13.1%, p<0.001). Differences in case fatality were found between PE patients with and without COVID-19 in 2020 (28.7% versus 12.5%, p<0.001), corresponding to a 3.1-fold increased risk of PE-related death (OR 3.16, 95% CI 2.91-3.42, p<0.001) in the presence of COVID-19. CONCLUSIONS In Germany, the prevalence of PE events during hospitalisations was similar in 2019 and 2020. However, the fatality rate among patients with both COVID-19 and PE was substantially higher than that in those with only one of these diseases, suggesting a life-threatening additive prognostic impact of the COVID-PE combination.

Published
2023

30. 1-Year Outcomes of Everolimus-Eluting Bioresorbable Scaffolds Versus Everolimus-Eluting Stents: A Propensity-Matched Comparison of the GHOST-EU and XIENCE V USA Registries

Author

Tamburino, Corrado, Capranzano, Piera, Gori, Tommaso, Latib, Azeem, Lesiak, Maciej, Nef, Holger, Caramanno, Giuseppe, Naber, Christopher, Mehilli, Julinda, Di Mario, Carlo, Sabaté, Manel, Münzel, Thomas, Colombo, Antonio, Araszkiewicz, Aleksander, Wiebe, Jens, Geraci, Salvatore, Jensen, Christoph, Mattesini, Alessio, Brugaletta, Salvatore, and Capodanno, Davide

Published
2016
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31. Evaluating Real-World Clinical Outcomes in Atrial Fibrillation Patients Receiving the WATCHMAN Left Atrial Appendage Closure Technology: Final 2-Year Outcome Data of the EWOLUTION Trial Focusing on History of Stroke and Hemorrhage

Author

Boersma, Lucas V., Ince, Hueseyin, Kische, Stephan, Pokushalov, Evgeny, Schmitz, Thomas, Schmidt, Boris, Gori, Tommaso, Meincke, Felix, Protopopov, Alexey Vladimir, Betts, Timothy, Mazzone, Patrizio, Foley, David, Grygier, Marek, Sievert, Horst, De Potter, Tom, Vireca, Elisa, Stein, Kenneth, Bergmann, Martin W., Al Nooryani, Arif, Fiedler, Thomas, Senatore, Gaetano, Brigadeau, François, Defaye, Pascal, Teiger, Emmanuel, Bonnet, Jean-Louis, Wald, Christof, Szili-Torok, Tamas, Tschishow, Wladimir, Crossland, David, Vahanian, Alec, Cruz-Gonzalez, Ignacio, Thambo, Jean-Benoit, Al Smadi, Faisal, Mudra, Harald, Molitoris, Robin, Folkeringa, Richard, Stevenhagen, Yorick, Gras, Daniel, Tamburino, Corrado, Molon, Giulio, Spence, Mark, Infante Oliveira, Eduardo, Merkulov, Evgeny, Sukiennik, Adam, Wong, Tom, Busch, Mathias, Boldt, Leif-Hendrik, Nickenig, Georg, and Neef, Martin

Published
2019
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35. Absorb Bioresorbable Vascular Scaffold Versus Everolimus-Eluting Metallic Stent in ST-Segment Elevation Myocardial Infarction: 1-Year Results of a Propensity Score Matching Comparison: The BVS-EXAMINATION Study (Bioresorbable Vascular Scaffold-A Clinical Evaluation of Everolimus Eluting Coronary Stents in the Treatment of Patients With ST-segment Elevation Myocardial Infarction)

Author

Brugaletta, Salvatore, Gori, Tommaso, Low, Adrian F., Tousek, Petr, Pinar, Eduardo, Gomez-Lara, Josep, Scalone, Giancarla, Schulz, Eberhard, Chan, Mark Y., Kocka, Viktor, Hurtado, Jose, Gomez-Hospital, Juan Antoni, Münzel, Thomas, Lee, Chi-Hang, Cequier, Angel, Valdés, Mariano, Widimsky, Petr, Serruys, Patrick W., and Sabaté, Manel

Published
2015
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36. Targeting myeloid cell coagulation signaling blocks MAP kinase/TGF-β1 driven fibrotic remodeling in ischemic heart failure

Author

Garlapati, Venkata, primary, Molitor, Michael, additional, Michna, Thomas, additional, Harms, Gregory S., additional, Finger, Stefanie, additional, Jung, Rebecca, additional, Lagrange, Jeremy, additional, Efentakis, Panagiotis, additional, Wild, Johannes, additional, Knorr, Maike, additional, Karbach, Susanne, additional, Wild, Sabine, additional, Vujacic-Mirski, Ksenija, additional, Münzel, Thomas, additional, Daiber, Andreas, additional, Brandt, Moritz, additional, Gori, Tommaso, additional, Milting, Hendrik, additional, Tenzer, Stefan, additional, Ruf, Wolfram, additional, and Wenzel, Philip, additional

Published
2022
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40. COVID-19 infection and its impact on case-fatality in patients with pulmonary embolism

Author

Hobohm, Lukas, Sagoschen, Ingo, Barco, Stefano, Farmakis, Ioannis T, Fedeli, Ugo, Koelmel, Sebastian, Gori, Tommaso, Espinola-Klein, Christine, Münzel, Thomas, Konstantinides, Stavros, Keller, Karsten, and University of Zurich

Subjects
10031 Clinic for Angiology, 610 Medicine & health, Cardiology and Cardiovascular Medicine
Abstract

Background Although a high prevalence of pulmonary embolism (PE) has been reported as a complication during severe COVID-19 infections in critical ill patients, nationwide data of hospitalized patients with COVID-19 with PE is still limited. Thus, we sought to analyze seasonal trends and predictors of in-hospital case-fatality in patients with COVID-19 and PE in Germany. Methods We used the German nationwide inpatient sample to analyze all data on hospitalizations for COVID-19 patients with and without PE in Germany during the year 2020 and to compare changes of PE prevalence to 2019. Results We analyzed data of 176,137 hospitalizations because of COVID-19 in 2020. Among those, PE was recorded in 1.9% (n=3,362) of discharge or death certificates. Almost one third of patients with COVID-19 and PE died during the in-hospital course (28.7%). The case-fatality rate increased with patients' age peaking in the 9th life-decade. Regardless of COVID-19, 196,203 inpatients were diagnosed with PE in Germany between 2019 and 2020. The number of PE hospitalizations were widely equally distributed between both years (98,485 vs. 97,718), while the case-fatality rate of all patients with PE was slightly lower in 2019 compared to 2020 (12.7% vs. 13.1%, P Conclusions In Germany, the prevalence of PE events complicating hospitalizations was similar in 2019 and 2020. However, the fatality rate among patients with COVID-19-associated PE was substantially higher than that in those without either COVID-19 or PE, indicating an additive prognostic effect of these two conditions. Funding Acknowledgement Type of funding sources: None.

Published
2022

41. Intravascular imaging in coronary stent restenosis: Prevention, characterization, and management

Author

Abouelnour, Amr and Gori, Tommaso

Subjects
Cardiology and Cardiovascular Medicine
Abstract

Despite the introduction of drug-eluting stents to combat the neointimal hyperplasia that occurred after BMS implantation, in-stent restenosis is still encountered in a significant number of patients, particularly as increasingly complex lesions are tackled by percutaneous coronary intervention. Many biological and mechanical factors interplay to produce restenosis, some of which are avoidable. Intravascular imaging provided unique insights into various forms of stent-related mechanical issues that contribute to this phenomenon. From a practical perspective, intravascular imaging can therefore help to optimize the stenting procedure to avert these issues. Moreover, once the problem of restenosis eventuates, imaging can guide the management by tackling the underlying identified mechanism. Finally, it can be used to evaluate the re-intervention results. Nevertheless, with the emergence of different treatment options, more evidence is needed to define patient/lesion-specific characteristics that may help to tailor treatment selection in a way that improves clinical outcomes.

Published
2022

44. Combined Analysis of Two Parallel Randomized Trials of Sirolimus-Coated and Paclitaxel-Coated Balloons in Coronary In-Stent Restenosis Lesions

Author

Scheller, Bruno, primary, Mangner, Norman, additional, Abdul Kader, Muhamad Ali S.K., additional, Wan Ahmad, Wan Azman, additional, Jeger, Raban, additional, Wöhrle, Jochen, additional, Ong, Tiong Kiam, additional, Liew, Houng Bang, additional, Gori, Tommaso, additional, Mahfoud, Felix, additional, Nuruddin, Amin Ariff, additional, Woitek, Felix, additional, Abidin, Imran Zainal, additional, Schwenke, Carsten, additional, Schnorr, Beatrix, additional, Mohd Ali, Rosli, additional, Scheller, Bruno, additional, Rastoul, Bianca, additional, Hollinger, Nicole, additional, Ewen, Sebastian, additional, Böhm, Michael, additional, Vukadinovic, Davor, additional, Kulenthiran, Saaraken, additional, Schwarz, Viktoria, additional, Clever, Yvonne P., additional, Linke, Axel, additional, Höllriegel, Robert, additional, Winzer, Ephraim, additional, Jellinghaus, Stefanie, additional, Hommel, Jennifer, additional, Abdul Kader, Muhamad Ali bin Sheikh, additional, Ismail, Muhammad Dzafir, additional, Mahmood Zuhdi, Ahmad Syadi, additional, Syed Mansor, Syed Mukhtar, additional, Kaiser, Christoph, additional, Fahrni, Gregor, additional, Gilgen, Nicole, additional, Harder-Allgöwer, Andrea, additional, Baumgartner, Margarete, additional, Sinisa, Markovic, additional, Smirnova, Olga, additional, Kiam Ong, Tiong, additional, Yip Fong, Alan Yean, additional, Khiew, Ning Zan, additional, Said, Asri Bin, additional, Cham, Yee Ling, additional, Oon, Yen Yee, additional, Koh, Keng Tat, additional, Voon, Chi Yen, additional, Mohd Amin, Nor Hanim bt, additional, Johan, Wilson anak, additional, Fui Jien, Mabelle Wong, additional, Shu Theng, Melanie Chong, additional, Gori, Tomasso, additional, Omar, Al Fazir, additional, Azmi, Shaiful, additional, Kandasamy, Balachandran, additional, Mohamed Yusoff, Ahmad Khairuddin, additional, Selamat, Salizah, additional, Kutschera, Maren, additional, and Mathana Sundram, Thavin Kumar, additional

Published
2022
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45. TCT-176 Randomized Comparison of Intracoronary Lithotripsy and Rotational Atherectomy for the Treatment of Severely Calcified Vessels—ROTA.shock Trial

Author

Nef, Holger, primary, Schlattner, Sophia, additional, Weissner, Melissa, additional, Gori, Tommaso, additional, Ullrich, Helen, additional, Gaede, Luise, additional, Achenbach, Stephan, additional, Möllmann, Helge, additional, Blumenstein, Johannes, additional, Aksoy, Adem, additional, Nickenig, Georg, additional, Weferling, Maren, additional, Dörr, Oliver, additional, Boeder, Niklas, additional, Bayer, Matthias, additional, Hamm, Christian, additional, and Blachutzik, Florian, additional

Published
2022
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46. Rotational Atherectomy or Balloon-Based Techniques to Prepare Severely Calcified Coronary Lesions

Author

Rheude, Tobias, primary, Fitzgerald, Sean, additional, Allali, Abdelhakim, additional, Mashayekhi, Kambis, additional, Gori, Tommaso, additional, Cuculi, Florim, additional, Kufner, Sebastian, additional, Hemetsberger, Rayyan, additional, Sulimov, Dmitriy S., additional, Rai, Himanshu, additional, Ayoub, Mohamed, additional, Bossard, Matthias, additional, Xhepa, Erion, additional, Fusaro, Massimiliano, additional, Toelg, Ralph, additional, Joner, Michael, additional, Byrne, Robert A., additional, Richardt, Gert, additional, Kastrati, Adnan, additional, Cassese, Salvatore, additional, and Abdel-Wahab, Mohamed, additional

Published
2022
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48. Use of intravascular ultrasound for optimal vessel sizing in chronic total occlusion percutaneous coronary intervention

Author

Blessing, Recha, primary, Buono, Andrea, additional, Ahoopai, Majid, additional, Geyer, Martin, additional, Knorr, Maike, additional, Brandt, Moritz, additional, Steven, Sebastian, additional, Drosos, Ioannis, additional, Muenzel, Thomas, additional, Wenzel, Philip, additional, Gori, Tommaso, additional, and Dimitriadis, Zisis, additional

Published
2022
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49. Manual der Arbeitsgruppe Interventionelle Kardiologie (AGIK) der Deutschen Gesellschaft für Kardiologie – Herz- und Kreislaufforschung e. V. (DGK)

Author

Nef, Holger M., Achenbach, Stephan, Birkemeyer, Ralf, Bufe, Alexander, Dörr, Oliver, Elsässer, Albrecht, Gaede, Luise, Gori, Tommaso, Hoffmeister, Hans M., Hofmann, Felix J., Katus, Hugo A., Liebetrau, Christoph, Massberg, Steffen, Pauschinger, Matthias, Schmitz, Thomas, Süselbeck, Tim, Voelker, Wolfram, Wiebe, Jens, Zahn, Ralf, Hamm, Christian, Zeiher, Andreas M., and Möllmann, Helge

Subjects
Herzkatheterlabor, Coronary angiography, PCI, Curriculum, Acute coronary syndrome, Koronarangiographie, Cardiovascular disease, Akutes Koronarsyndrom, Koronare Herzerkrankung, Catheter laboratory
Abstract

Dieses Manual zur diagnostischen Herzkatheteruntersuchung (Teil 1) ist eine Anwendungsempfehlung für interventionell tätige Ärzte, die den gegenwärtigen Kenntnisstand unter Berücksichtigung neuester Studienergebnisse wiedergibt. Hierzu wurde in den einzelnen Kapiteln speziell auf die Alltagstauglichkeit der Empfehlungen geachtet, sodass dieses Manual jedem interventionell tätigen Kardiologen als Entscheidungshilfe im Herzkatheterlabor dienen soll. Trotz der von vielen Experten eingebrachten praktischen Hinweise kann dieses Manual dennoch nicht die ärztliche Evaluation des individuellen Patienten ersetzen und damit eine Anpassung der Diagnostik bzw. Therapie ersetzen. Zusatzmaterial online Die Online-Version dieses Beitrags (10.1007/s12181-021-00493-6) enthält ein Inhaltsverzeichnis und einen Anhang bestehend aus Klassifikationen und Definitionen, einem Abbildungs- und einem Tabellenverzeichnis. Beitrag und Zusatzmaterial stehen Ihnen im elektronischen Volltextarchiv auf http://www.springermedizin.de/der-kardiologe zur Verfügung. Sie finden das Zusatzmaterial am Beitragsende unter „Supplementary Material“.

Published
2021

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